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Roberto Spina, Neil Simon, Romesh Markus, David W M Muller, Krishna Kathir
Contrast-induced encephalopathy (CIE) is an acute and reversible neurological disturbance associated with the intra-arterial administration of iodinated contrast medium during cardiac catheterisation. It may manifest with encephalopathy, motor and sensory disturbances; vision disturbances, including cortical blindness, ophthalmoplegia, aphasia; and seizures. Disruption of the blood-brain barrier and direct neuronal toxicity are believed to be implicated in the pathophysiology of the syndrome. Symptoms appear soon after contrast administration and resolve completely within 24-48 h...
February 2017: Internal Medicine Journal
Roberto Spina, Neil Simon, Romesh Markus, David Wm Muller, Krishna Kathir
OBJECTIVES: To describe the epidemiology, pathophysiology, clinical presentation, and management of contrast-induced encephalopathy (CIE) following cardiac catheterization. BACKGROUND: CIE is an acute, reversible neurological disturbance directly attributable to the intra-arterial administration of iodinated contrast medium. METHODS: The PubMed database was searched and all cases in the literature were retrieved and reviewed. RESULTS: 52 reports of CIE following cardiac catheterization were found...
November 29, 2016: Catheterization and Cardiovascular Interventions
Efrén Martínez-Quintana, Fayna Rodríguez-González, José María Medina-Gil, Paloma Garay-Sánchez, Antonio Tugores
INTRODUCTION: Paraoxonase 1 (PON1) plays a major role in the oxidation of low density lipoprotein and in the prevention of coronary atherogenesis. In this context, coding region polymorphisms of PON1 gene, responsible for the enzyme activity, has become of interest as a marker for atherogenesis. METHODS: A study and follow-up was conducted on 529 patients with an acute coronary event in order to assess the association between the PON1 Q192R (rs662;A/G) polymorphism, the type of acute coronary syndrome, cardiovascular risk factors (arterial hypertension, diabetes mellitus, dyslipidaemia, and smoking), the extent and severity of coronary atherosclerosis, and the medium-term clinical follow-up...
January 2017: Clínica e Investigación en Arteriosclerosis
Luiz Minuzzo, Elizabete Silva dos Santos, Ari Timerman
BACKGROUND: Cardiovascular disease is the leading cause of mortality in the western world and its treatment should be optimized to decrease severe adverse events. OBJECTIVE: To determine the effect of previous use of angiotensin-converting enzyme inhibitors on cardiac troponin I measurement in patients with acute coronary syndrome without ST-segment elevation and evaluate clinical outcomes at 180 days. METHODS: Prospective, observational study, carried out in a tertiary center, in patients with acute coronary syndrome without ST-segment elevation...
December 2014: Arquivos Brasileiros de Cardiologia
Sandra Gómez-Talavera, David Vivas, María Jose Perez-Vizcayno, Rosana Hernández-Antolín, Antonio Fernández-Ortíz, Camino Bañuelos, Javier Escaned, Pilar Jiménez-Quevedo, Dafne Viliani, Isidre Vilacosta, Carlos Macaya, Fernando Alfonso
INTRODUCTION: Conduction disorders in patients with ST-segment elevation myocardial infarction (STEMI) are associated with high mortality. Previous studies have analyzed the implications of AVB in acute coronary syndrome treated with fibrinolysis. However, the implications of AVB in patients with STEMI treated with primary angioplasty have not been sufficiently studied. MATERIAL AND METHODS: 913 patients with STEMI treated with primary angioplasty. All clinical, electrocardiographic and angiographic variables were collected...
March 2014: Acute Cardiac Care
Laura Davidson, Jane Wilcox, David Kim, Stewart Benton, Joseph Fredi, Douglas Vaughan
BACKGROUND: Acute coronary syndrome due to acute plaque rupture has been well described and is associated with established risk factors, including hypertension, diabetes mellitus, hyperlipidemia, and smoking. The prevalence of these risk factors in very young patients (aged ≤35 years) is not well known, and they may have other nontraditional risk factors. We hypothesized that acute coronary syndrome in very young patients may represent a thrombotic event independent of underlying atherosclerotic disease...
February 2014: American Journal of Medicine
Khalid A Alnemer, Hussam F Alfaleh, Khalid F Alhabib, Anhar Ullah, Ahmad Hersi, Shukri Alsaif, Amir Taraben, Gamal Hussein, Modather Butt
BACKGROUND: Diabetes mellitus (DM) is a major public health problem in Saudi Arabia. DM patients who present with acute coronary syndrome (ACS) have worse cardiovascular outcomes. We characterized clinical features and hospital outcomes of diabetic patients with ACS in Saudi Arabia. METHODS: ACS patients enrolled in the Saudi Project for Assessment of Acute Coronary Syndrome (SPACE) study from December 2005 to December 2007, either with DM or newly diagnosed during hospitalization were eligible...
October 2012: Journal of the Saudi Heart Association
Emad Ahmed, Khalid F Alhabib, Ayman El-Menyar, Nidal Asaad, Kadhim Sulaiman, Ahmad Hersi, Wael Almahmeed, Alawi A Alsheikh-Ali, Haitham Amin, Ahmed Al-Motarreb, Shukri Al Saif, Rajvir Singh, Jawad Al-Lawati, Jassim Al Suwaidi
CONTEXT: Elderly patients have more cardiovascular risk factors and a greater burden of ischemic disease than younger patients. AIMS: To examine the impact of age on clinical presentation and outcomes in patients presenting with acute coronary syndrome (ACS). METHODS AND MATERIAL: Collected data from the 2nd Gulf Registry of Acute Coronary Events (Gulf RACE-2), which is a prospective multicenter study from six adjacent Arab Middle Eastern Gulf countries...
June 2013: Journal of Cardiovascular Disease Research
Shinichiro Fujimoto, Takeshi Kondo, Takahide Kodama, Tadaaki Orihara, Junichi Sugiyama, Makoto Kondo, Akira Endo, Hiroshi Fukazawa, Hideki Nagaoka, Akitsugu Oida, Takanori Ikeda, Junichi Yamazaki, Shinichi Takase, Jagat Narula
BACKGROUND:  Coronary computed tomography angiography (CTA) findings of positive vessel remodeling and low-attenuation plaque, referred to as computed tomography-verified high-risk plaque (CT-HRP), have been reported to be associated with the development of subsequent acute coronary syndromes. The aim of this study was to examine the usefulness of coronary CTA for coronary risk re-stratification of patients with asymptomatic and atypical chest symptoms. METHODS AND RESULTS:  A total of 1,139 subjects (M/F 602/537; mean age, 61...
2012: Circulation Journal: Official Journal of the Japanese Circulation Society
David Z Rose, Sebastian Koch, Yolanda Reyes-Iglesias, Dileep R Yavagal
A morbidly obese, diabetic, hypertensive patient, with severe intracranial left middle cerebral artery (MCA) stenosis, suffered recurrent stereotyped transient ischemic attacks over 2 months, despite taking daily antiplatelet agents, high dose statin, insulin and an angiotensin converting enzyme inhibitor. A left MCA (M1) Wingspan stent-assisted angioplasty was performed after standard loading, and daily doses of clopidogrel were given 3 days prior to the procedure. Immediately after the procedure, the patient developed a left hemispheric ischemic stroke syndrome...
September 1, 2013: Journal of Neurointerventional Surgery
Wiwun Tungsubutra, Chunhakasem Chotnaiwattarakul, Adisak Maneesai, Saowanee Naowapanich, Pradit Panchavinnin, Damras Tresukosol, Rewat Phankingtongkhum, Nattawut Wongpraparut
BACKGROUND: Treatment of acute coronary syndrome requires a reliable measurement of quality for ensuring evidence-based care. Clinical registries have been used to support quality improvement activities in some countries, but there are few data concerning their implementation in developing countries. In 2008, a multidisciplinary Siriraj ST segment elevation myocardial infarction (STEMI) registry team was formed with the intention to improve the process of care. This report summarizes observational data collected within the first year to characterize the clinical profile, management and in-hospital outcomes of STEMI patients at the author's institute...
February 2012: Journal of the Medical Association of Thailand, Chotmaihet Thangphaet
Paul Erne, Felix Gutzwiller, Philip Urban, Marco Maggiorini, Pierre-Frédéric Keller, Dragana Radovanovic
OBJECTIVES: Little is known about patients without known modifiable risk factors presenting initially with acute coronary syndrome (ACS). This study assessed baseline characteristics and outcomes of ACS patients with and without the known modifiable risk factors arterial hypertension, dyslipidemia, obesity, smoking or diabetes. METHODS: All ACS patients enrolled in the AMIS Plus Registry between 1997 and 2010 were analyzed until hospital discharge; a subgroup was re-assessed at the 1-year follow-up...
2012: Cardiology
Alexander Tenenbaum, Diego Medvedofsky, Enrique Z Fisman, Liudmila Bubyr, Shlomi Matetzky, David Tanne, Robert Klempfner, Joseph Shemesh, Ilan Goldenberg
BACKGROUND: The effect of combination of fibrate with statin on major adverse cardiovascular events (MACE) following acute coronary syndrome (ACS) hospitalization is unclear. The main aim of this study was to investigate the 30-day rate of MACE in patients who participated in the nationwide ACS Israeli Surveys (ACSIS) and were treated on discharge with a fibrate (mainly bezafibrate) and statin combination vs. statin alone. METHODS: The study population comprised 8,982 patients from the ACSIS 2000, 2002, 2004, 2006, 2008 and 2010 enrollment waves who were alive on discharge and received statin...
2012: PloS One
Moeness Moustafa Alshishtawy
No abstract text is available yet for this article.
February 2012: Sultan Qaboos University Medical Journal
Wayne Tymchak, Paul W Armstrong, Cynthia M Westerhout, Sunil Sookram, Neil Brass, Yuling Fu, Robert C Welsh
INTRODUCTION: Contemporary non-ST-elevation myocardial infarction-acute coronary syndrome guidelines emphasize early-risk stratification and optimizing therapy including an invasive strategy in high-risk patients. To assess the feasibility of initiating this strategy in the prehospital environment, we examined how such patients are transported to hospital, their risk profile, and the proportion potentially eligible for such a strategy. METHODS: Consecutive patients with ST-segment elevation myocardial infarction admitted in Edmonton were studied between September and November 2008 and divided according to their mode of transport to hospital: emergency medical services (EMS) versus self-presenting...
September 2011: American Heart Journal
Noriaki Kume, Hirokazu Mitsuoka, Kazutaka Hayashida, Masaru Tanaka, Toru Kita
BACKGROUND: Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is implicated in atherosclerotic plaque vulnerability. It is shed, in part, by proteases and released as soluble LOX-1 (sLOX-1), which is a specific and sensitive biomarker of acute coronary syndrome (ACS). The present study explored if sLOX-1 can also predict prognosis after ACS. METHODS AND RESULTS: ACS patients undergoing emergency percutaneous coronary intervention and measurement of circulating sLOX-1 were followed (median: 896 days)...
July 2010: Circulation Journal: Official Journal of the Japanese Circulation Society
Yafim Brodov, Amir Sandach, Valentina Boyko, Shlomi Matetzky, Victor Guetta, Lori Mandelzweig, Solomon Behar
BACKGROUND: In an investigation of the relationship between myocardial infarction (MI) preceded by certain activities or events and coronary angiographic data, including the extent of atherothrombotic involvement during acute MI, we hypothesized that when comparing patients with MI that was preceded by potential triggering activities (PTA "+") to MI without PTA, the former might have a distinct pathogenic basis exhibiting different angiographic and clinical features. METHODS: In the framework of a national survey on acute coronary syndromes conducted during a 2-month period in 2002, 662 acute MI patients with complete angiographic data were divided into two groups, according to whether or not they reported the presence of specific unusual events or activities immediately preceding the onset of MI...
November 12, 2008: International Journal of Cardiology
Pedro Monteiro
BACKGROUND: Performance of coronary artery bypass graft (CABG) during an acute coronary syndrome (ACS) is mainly used in high-risk patients. Although potentially life-saving, patients undergoing early CABG are traditionally associated with a worse outcome than those not requiring CABG. Is this really true in an unselected ACS population? The aim of this study was to evaluate, in an ACS population, if the performance of CABG during the index hospitalization influences in-hospital outcome...
July 4, 2006: Circulation
Francisco Sampaio, Pedro Mateus, Nuno Bettencourt, Carla Costa Dias, Luís Adão, Lino Santos, Madalena Teixeira, Lino Simões, Vasco Gama
INTRODUCTION: Ischemic heart disease is a major cause of heart failure in western societies. However, the factors that may influence left ventricular function (LVF) recovery after an acute coronary syndrome (ACS) are still unclear. OBJECTIVE: To identify variables that may influence LVF evolution one year after ACS. METHODS: 104 patients hospitalized with ACS between 7/1/2001 and 12/31/2002 and with systolic dysfunction--defined as an echocardiographic ejection fraction (EF) < or = 45%--were randomly allocated to a planned coronary follow-up program (FUP) or a general cardiology clinic (GC); patients from both groups were also randomly referred to a structured cardiac rehabilitation program (CRP)...
March 2006: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
Hiroaki Kawano, Hirofumi Soejima, Sunao Kojima, Akira Kitagawa, Hisao Ogawa et al.
BACKGROUND: Acute myocardial infarction (AMI) is prevalent and has serious consequences including re-infarction and death. Although the risk factors for AMI have been extensively studied in Western countries, they are less well documented in Japan. To determine the risk factors for AMI, we performed a case-control study in unselected patients with AMI. METHODS AND RESULTS: Risk factors were assessed in 1,925 consecutive patients with a first AMI (age, 28-103 years old; men, 1,353; women, 572), who were admitted to one of the major institutes in Japan, and in 2,279 age-and sex-matched population-based controls...
May 2006: Circulation Journal: Official Journal of the Japanese Circulation Society
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