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https://www.readbyqxmd.com/read/27878066/a-rare-case-of-invasive-apocrine-carcinoma-of-the-breast-with-unusual-radiologic-findings
#1
Ji Min Kim, Shin Young Kim, Mee Hye Oh, Jong Eun Lee
Invasive apocrine carcinoma (IAC) of the breast is a rare subtype of breast malignancy. Its incidence is not well known, but it is approximately less than 1% to 4%. For these reasons, there are few reports and little information on the radiologic appearance of IAC. Furthermore, most of the case reports show malignant features which are similar to invasive ductal carcinoma (IDC). We present a rare case of IAC without typical malignant feature on mammography, and ultrasonography (USG). Imaging findings on computed tomography (CT), magnetic resonance imaging (MRI), and 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT are also presented...
July 2016: Iranian Journal of Radiology: a Quarterly Journal Published By the Iranian Radiological Society
https://www.readbyqxmd.com/read/27864717/intraoperative-localization-of-the-parathyroid-glands-with-indocyanine-green-and-firefly-r-technology-during-baba-robotic-thyroidectomy
#2
Hyeong Won Yu, Joon Woo Chung, Jin Wook Yi, Ra-Yeong Song, Joon-Hyop Lee, Hyungju Kwon, Su-Jin Kim, Young Jun Chai, June Young Choi, Kyu Eun Lee
BACKGROUND: It is unclear whether near-infrared (NIR) light-induced indocyanine green (ICG) fluorescence can effectively identify, and thus permit the preservation of, parathyroid glands in bilateral axillo-breast approach (BABA) robotic thyroidectomy. This case-control study with a prospectively recruited consecutive series and a retrospectively selected control group assessed the usefulness of ICG with Firefly(R) technology to identify the parathyroid glands intraoperatively during BABA robotic thyroidectomy...
November 18, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27862996/tannic-acid-inhibits-egfr-stat1-3-and-enhances-p38-stat1-signalling-axis-in-breast-cancer-cells
#3
Pramod Darvin, Youn Hee Joung, Dong Young Kang, Nipin Sp, Hyo Joo Byun, Tae Sook Hwang, Hema Sasidharakurup, Chi Ho Lee, Kwang Hyun Cho, Kyung Do Park, Hak Kyo Lee, Young Mok Yang
Tannic acid (TA), a naturally occurring polyphenol, is a potent anti-oxidant with anti-proliferative effects on multiple cancers. However, its ability to modulate gene-specific expression of tumour suppressor genes and oncogenes has not been assessed. This work investigates the mechanism of TA to regulate canonical and non-canonical STAT pathways to impose the gene-specific induction of G1-arrest and apoptosis. Regardless of the p53 status and membrane receptors, TA induced G1-arrest and apoptosis in breast cancer cells...
November 15, 2016: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/27837296/comparison-of-local-recurrence-after-simple-and-skin-sparing-mastectomy-performed-in-patients-with-ductal-carcinoma-in-situ
#4
Simon Timbrell, Sarah Al-Himdani, Oliver Shaw, Kian Tan, Julie Morris, Nigel Bundred
BACKGROUND: The incidence of ductal carcinoma in situ (DCIS) is increasing with the use of screening mammography, and approximately 30% of all women diagnosed with DCIS are treated by mastectomy. There is increasing use of a skin-sparing mastectomy (SSM) approach to surgically excise DCIS as this facilitates immediate breast reconstruction. The rates of locoregional recurrence (LRR) after simple mastectomy performed for pure DCIS are historically reported as 1%; however, international data suggest that LRR after SSM may be higher...
November 11, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27835650/zhx1-promotes-the-proliferation-migration-and-invasion-of-cholangiocarcinoma-cells
#5
Ryuk-Jun Kwon, Myoung-Eun Han, Ji-Young Kim, Liangwen Liu, Yun-Hak Kim, Jin-Sup Jung, Sae-Ock Oh
Zinc-fingers and homeoboxes 1 (ZHX1) is a transcription repressor that has been associated with the progressions of hepatocellular carcinoma, gastric cancer, and breast cancer. However, the functional roles of ZHX1 in cholangiocarcinoma (CCA) have not been determined. We investigated the expression and roles of ZHX1 during the proliferation, migration, and invasion of CCA cells. In silico analysis and immunohistochemical studies showed amplification and overexpression of ZHX1 in CCA tissues. Furthermore, ZHX1 knockdown using specific siRNAs decreased CCA cell proliferation, migration, and invasion, whereas ZHX1 overexpression promoted all three characteristics...
2016: PloS One
https://www.readbyqxmd.com/read/27813039/the-apocrine-profile-of-triple-negative-breast-carcinomas-in-patients-aged-45-years-or-younger-favorable-but-rare-features
#6
Sergio Mitsuo Masili-Oku, Carlos Eduardo Bacchi, Felipe Seabra Fernandes, José Roberto Filassi, Edmund C Baracat, Filomena Marino Carvalho
Objective Triple-negative breast carcinomas (TNBCs) represent a heterogeneous group of neoplasias, even though they generally exhibit a clinically more aggressive phenotype, and are more prevalent in young women. To date, targeted therapies for this group of tumors have not been defined. The aim of this study was to evaluate the frequency of the apocrine subtype in TBNCs from premenopausal patients as defined by the immunohistochemical expression of the androgen receptor (AR) and its association with: histological type; tumor grade; proliferative activity; epidermal growth factor receptor (EGFR) expression; and a basal-like phenotype...
October 2016: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/27806774/-strategy-of-points-lines-and-layers-in-needle-assisted-laparoscope-functional-modified-neck-dissection-through-bilateral-breast-approach
#7
W X Zhao, B Wang, S Y Yan, L Y Zhang
The incidence of papillary thyroid carcinoma is growing rapidly. Especially in young patients, the patients have high demand for better cosmetic effect and less psychological trauma. The application of laparoscope technique in papillary thyroid carcinoma surgery should meet the needs of patients. The development of needle assisted technique make it easy to access the neck potential fascial spaces, and provide the basic instrument for laparoscope modified neck dissection. The application of needle assisted techniques mainly include suture suspension and V type needle retractor, MiniLap, 3 mm laparoscopic apparatus...
November 1, 2016: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/27796081/intravoxel-incoherent-motion-ivim-derived-parameters-in-diffusion-weighted-mri-associations-with-prognostic-factors-in-invasive-ductal-carcinoma
#8
Youn Joo Lee, Sung Hun Kim, Bong Joo Kang, Young Jee Kang, Heesoo Yoo, Jaewan Yoo, Jaeun Lee, Yo Han Son, Robert Grimm
PURPOSE: To investigate relationships between intravoxel incoherent motion (IVIM) metrics of invasive ductal carcinoma of the breast and prognostic factors. MATERIALS AND METHODS: This retrospective study included a total of 82 masses from 72 patients who underwent 3T breast magnetic resonance imaging (MRI) and diffusion-weighted imaging. IVIM metrics of tissue diffusivity (Dslow ), pseudodiffusivity (Dfast ), and perfusion fraction (Dpf ) were measured using histogram analysis for whole lesion volumes...
October 31, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27788957/targeting-phosphatidylinositol-4-kinase-iii%C3%AE-for-radiosensitization-a-potential-model-of-drug-repositioning-using-an-anti-hepatitis-c-viral-agent
#9
Jeanny Kwon, Dan Hyo Kim, Ji Min Park, Young Hee Park, Yeo Hyun Hwang, Hong-Gyun Wu, Kyung Hwan Shin, In Ah Kim
PURPOSE: To investigate which isotype of phosphatidylinositol 4-kinase (PI4K) may affect radiosensitivity and examine whether anti-hepatitis C viral (HCV) agents, some of which have been shown to inhibit PI4K IIIα activity, could be repositioned as a radiosensitizer in human cancer cells. METHODS AND MATERIALS: U251, BT474, and HepG2 cell lines and normal human astrocyte were used. Ribonucleic acid interference, clonogenic assays, Western blotting, immunofluorescence, annexin V assay, lysotracker staining, and β-galactosidase assay were performed...
November 15, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27779695/enhancement-of-radiosensitivity-by-inhibition-of-c-jun-n-terminal-kinase-activity-in-a-lewis-lung-carcinoma%C3%A2-bearing-subcutaneous-tumor-mouse-model
#10
Chun-Hao Li, Sa-Hoe Lim, Hyang-Hwa Ryu, Kyung-Sub Moon, Tae-Young Jung, Shin Jung
Stereotactic radiosurgery has been recognized as an effective treatment approach for metastatic brain tumors. By increasing the sensitivity of the tumor to radiation and decreasing the marginal dose, it is possible to improve therapeutic efficacy and decrease side-effects. In radiation-induced cells, c-Jun N-terminal kinase (JNK) signaling mediates the phosphorylation of H2AX, which indicates DNA damage sensitivity and modulates the effect of radiation. Lewis lung cancer (LLC) and breast cancer (4T1) cells were irradiated with a Gamma Knife in cell culture tubes...
October 25, 2016: Oncology Reports
https://www.readbyqxmd.com/read/27771499/breast-cancer-in-women-aging-35-years-old-and-younger-the-egyptian-national-cancer-institute-nci-experience
#11
A D Darwish, A M Helal, N H Aly El-Din, L L Solaiman, A Amin
OBJECTIVE: The aim is to identify the epidemiological and clinicopathological features associated with young breast cancer (BC) patients and to discuss factors affecting tumor recurrence and DFS. PATIENTS & METHODS: A retrospective analysis was conducted based on medical records from young females patients aged ≤35 years with pathologically confirmed primary breast cancer treated during 2008-2010 at NCI. Cases with non invasive cancer and non carcinoma histology are excluded...
October 20, 2016: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/27770782/triple-negative-breast-cancer-in-north-of-morocco-clinicopathologic-and-prognostic-features
#12
Touria Derkaoui, Joaira Bakkach, Mohamed Mansouri, Ali Loudiyi, Mohamed Fihri, Fatima Zahra Alaoui, Amina Barakat, Bouchra El Yemlahi, Hassan Bihri, Naima Ghailani Nourouti, Mohcine Bennani Mechita
BACKGROUND: Triple Negative Breast Cancer (TNBC) is defined by a lack of estrogen and progesterone receptor gene expression and by the absence of overexpression on HER2. It is associated to a poor prognosis. We propose to analyze the clinicopathologic and prognostic characteristics of this breast cancer subtype in a Mediterranean population originated or resident in the North of Morocco. METHODS: We conducted a retrospective study of 279 patients diagnosed with breast cancer between January 2010 and January 2015...
October 22, 2016: BMC Women's Health
https://www.readbyqxmd.com/read/27764910/magnetic-resonance-imaging-and-pathological-characteristics-of-pure-mucinous-carcinoma-in-the-breast-according-to-echogenicity-on-ultrasonography
#13
Young Gyung Shin, Eun-Kyung Kim, Min Jung Kim, Jung Hyun Yoon, Hee Jung Moon
Purpose: The aim of this study was to explore the clinical and pathological characteristics of pure mucinous breast carcinoma (PMBC) according to internal echogenicity on ultrasonography (US). Methods: Thirty-three patients with PMBC diagnosed at surgery were included in this study. Cases of PMBC were classified according to internal echogenicity on US. The imaging features on magnetic resonance (MR) imaging and clinicohistopathological characteristics were compared between the hypoechogenic and the isoechogenic to hyperechogenic groups...
August 29, 2016: Ultrasonography
https://www.readbyqxmd.com/read/27743835/sclerosing-odontogenic-carcinoma-presenting-on-the-hard-palate-of-a-43-year-old-female-a-case-report
#14
Andrew Wood, Fiona Young, James Morrison, Brendon I Conn
We present a case of sclerosing odontogenic carcinoma (SOC) occurring on the hard palate of a 43-year-old female. The tumor presented as an asymptomatic firm swelling and histopathologically was characterized by widely dispersed nests and cords of bland cells infiltrating between hyalinized collagen fibers. Prominent perineural and intraneural invasion and erosion of bone was noted. The tumor cells showed staining with antibodies to pan-cytokeratin (PanCK), cytokeratin 19 (CK19), cytokeratin 5/6 (CK5/6), cytokeratin 14 (CK14), p63 and E-cadherin, but no staining with antibodies to carcinoembryonic antigen (CEA), cytokeratin 7 (CK7), cytokeratin 20 (CK20), estrogen receptor (ER), progesterone receptor (PR) or S100...
December 2016: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/27721882/breast-cancer-detection-in-a-screening-population-comparison-of-digital-mammography-computer-aided-detection-applied-to-digital-mammography-and-breast-ultrasound
#15
Kyu Ran Cho, Bo Kyoung Seo, Ok Hee Woo, Sung Eun Song, Jungsoon Choi, Shin Young Whang, Eun Kyung Park, Ah Young Park, Hyeseon Shin, Hwan Hoon Chung
PURPOSE: We aimed to compare the detection of breast cancer using full-field digital mammography (FFDM), FFDM with computer-aided detection (FFDM+CAD), ultrasound (US), and FFDM+CAD plus US (FFDM+CAD+US), and to investigate the factors affecting cancer detection. METHODS: In this retrospective study conducted from 2008 to 2012, 48,251 women underwent FFDM and US for cancer screening. One hundred seventy-one breast cancers were detected: 115 invasive cancers and 56 carcinomas in situ...
September 2016: Journal of Breast Cancer
https://www.readbyqxmd.com/read/27721880/breast-imaging-reporting-and-data-system-category-3-lesions-detected-on-whole-breast-screening-ultrasound
#16
Sang Yu Nam, Eun Young Ko, Boo-Kyung Han, Jung Hee Shin, Eun Sook Ko, Soo Yeon Hahn
PURPOSE: This study assessed the incidence and cancer rate of probably benign lesions detected on bilateral whole-breast screening ultrasound (US), which corresponded to US Breast Imaging Reporting and Data System (BI-RADS) category 3, and evaluated the proper management of those lesions. METHODS: This study was approved by the Institutional Review Board in our institution, which waived informed patient consent. We retrospectively reviewed US images of 1,666 patients who underwent bilateral whole-breast screening US as a supplemental screening test to negative screening mammography or screening US only...
September 2016: Journal of Breast Cancer
https://www.readbyqxmd.com/read/27694902/functional-redundancy-between-apc-and-apc2-regulates-tissue-homeostasis-and-prevents-tumorigenesis-in-murine-mammary-epithelium
#17
C S Daly, P Shaw, L D Ordonez, G T Williams, J Quist, A Grigoriadis, J H Van Es, H Clevers, A R Clarke, K R Reed
Aberrant Wnt signaling within breast cancer is associated with poor prognosis, but regulation of this pathway in breast tissue remains poorly understood and the consequences of immediate or long-term dysregulation remain elusive. The exact contribution of the Wnt-regulating proteins adenomatous polyposis coli (APC) and APC2 in the pathogenesis of human breast cancer are ill-defined, but our analysis of publically available array data sets indicates that tumors with concomitant low expression of both proteins occurs more frequently in the 'triple negative' phenotype, which is a subtype of breast cancer with particularly poor prognosis...
October 3, 2016: Oncogene
https://www.readbyqxmd.com/read/27670257/pathologic-findings-at-risk-reducing-salpingo-oophorectomy-rrso-in-germline-brca-mutation-carriers-with-breast-cancer-significance-of-bilateral-rrso-at-the-optimal-age-in-germline-brca-mutation-carriers
#18
Young Jae Lee, Shin Wha Lee, Kyu Rae Kim, Kyung Hae Jung, Jong Won Lee, Yong Man Kim
OBJECTIVE: Most BRCA1/2 carriers do not undergo risk-reducing salpingo-oophorectomy (RRSO) by the recommended age. This study aimed to find the incidence of precursor lesions and cancer after RRSO. METHODS: We retrospectively reviewed breast cancer patients identified as BRCA mutation carriers who underwent RRSO at Asan Medical Center, Seoul, Korea, from 2010 to 2014. From 2013, all cases were examined according to the Sectioning and Extensively Examining the Fimbria (SEE/FIM) protocol and underwent immunohistochemically staining...
August 8, 2016: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/27668497/bilateral-corneal-epithelial-lesions-associated-with-paclitaxel
#19
Hyo Seok Lee, Jun Young Ha, Won Choi, Kyung Chul Yoon
PURPOSE: An antineoplastic drug, paclitaxel, is widely used in small cell lung cancer, breast cancer, and ovarian cancer. We report a case of bilateral, vision-impairing corneal epithelial lesions that developed in a patient receiving paclitaxel monotherapy for breast cancer. CASE REPORT: A 45-year-old woman presented with a 1-month history of bilateral visual disturbances. She had been receiving paclitaxel chemotherapy after modified radical mastectomy for invasive ductal carcinoma in her left breast...
October 2016: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/27658723/the-upr-inducer-dpp23-inhibits-the-metastatic-potential-of-mda-mb-231-human-breast-cancer-cells-by-targeting-the-akt-ikk-nf-%C3%AE%C2%BAb-mmp-9-axis
#20
Soon Young Shin, Chang Gun Kim, You Jung Jung, Yoongho Lim, Young Han Lee
(E)-3-(3,5-dimethoxyphenyl)-1-(2-methoxyphenyl)prop-2-en-1-one (DPP23) is a synthetic polyphenol derivative that selectively induces apoptosis in cancer cells through the unfolded protein response pathway. In the present study, we evaluated the effect of DPP23 on tumour invasion and metastasis. Here, we show that DPP23 inhibited tumour necrosis factor alpha (TNFα)-induced motility, F-actin formation, and the invasive capability of MDA-MB-231 cells. DPP23 inhibited NF-κB-dependent MMP-9 expression at the transcriptional level...
2016: Scientific Reports
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