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https://www.readbyqxmd.com/read/29780787/non-convulsive-seizure-related-to-cremophor-el%C3%A2-free-polymeric-micelle-formulation-of-paclitaxel-a-case-report
#1
Yoon Sun Shin, Kyung Jin Min, Seung Young Choi, Nak Woo Lee
Paclitaxel is a chemotherapeutic agent that is effective against ovarian, breast, lung, and other cancers. Although peripheral neurotoxicity is among the most common side effects of paclitaxel treatment, central neurotoxicity is rarely reported. When centrally mediated side effects are observed, they are attributed to Cremophor EL™ (CrEL), a surfactant-containing vehicle used for paclitaxel administration. In the present report, we discuss the case of a 72-year-old woman with ovarian carcinoma who experienced a non-convulsive seizure following administration of a CrEL-free, polymeric micelle formulation of paclitaxel...
May 2018: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/29755131/kmt2c-mediates-the-estrogen-dependence-of-breast-cancer-through-regulation-of-er%C3%AE-enhancer-function
#2
Kinisha Gala, Qing Li, Amit Sinha, Pedram Razavi, Madeline Dorso, Francisco Sanchez-Vega, Young Rock Chung, Ronald Hendrickson, James Hsieh, Michael Berger, Nikolaus Schultz, Alessandro Pastore, Omar Abdel-Wahab, Sarat Chandarlapaty
Estrogen receptor alpha (ERα) is a ligand-activated nuclear receptor that directs proliferation and differentiation in selected cancer cell types including mammary-derived carcinomas. These master-regulatory functions of ERα require trans-acting elements such as the pioneer factor FOXA1 to establish a genomic landscape conducive to ERα control. Here, we identify the H3K4 methyltransferase KMT2C as necessary for hormone-driven ERα activity and breast cancer proliferation. KMT2C knockdown suppresses estrogen-dependent gene expression and causes H3K4me1 and H3K27ac loss selectively at ERα enhancers...
May 14, 2018: Oncogene
https://www.readbyqxmd.com/read/29703057/second-malignancy-in-young-early-stage-breast-cancer-patients-with-modern-radiotherapy-a-long-term-population-based-study-a-strobe-compliant-study
#3
Liyi Xie, Chen Lin, Huan Zhang, Xuhui Bao
Second cancer is a leading cause of death in long-term survivors of younger early-stage breast cancer patients. To date, relationship of age, receipt of radiotherapy (RT), and estimated doses received by target organs have not yet been well elucidated. Using Surveillance, Epidemiology, and End Results database, patients aged 20 to 44, diagnosed with a first primary staging I-IIIA ipsilateral breast invasive ductal carcinoma, underwent surgery during 1988 to 2009 were identified, and those with a second malignancy at ≥1-year follow-up were analyzed to calculate cumulative incidences (CIs) of second malignancy in whole group and each subgroup...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29702014/mucocelelike-lesions-in-the-breast-radiologic-and-clinicopathologic-correlations-with-upgrade-rate
#4
Su Min Ha, Joo Hee Cha, Hee Jung Shin, Eun Young Chae, Woo Jung Choi, Hak Hee Kim
OBJECTIVE: The purpose of this article is to investigate the radiologic and clinicopathologic findings of mucocelelike lesions (MLLs) and the rate of pathologic upgrade with factors predicting it. MATERIALS AND METHODS: We reviewed our institution's database from January 2006 to December 2012 and enrolled 89 women with 89 MLLs. The pathologic findings from the initial biopsies identified 71 lesions without and 18 lesions with associated high-risk lesions. Images were reviewed according to the BI-RADS lexicon...
April 27, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29650825/-successful-breast-conserving-surgery-for-simultaneous-and-ipsilateral-multiple-breast-carcinomas-of-young-patient-a-case-report
#5
Hitomi Kubota, Keita Adachi, Shuhei Suzuki, Shigeru Fujisaki, Yukiko Hara, Katsuhisa Enomoto, Ryouichi Tomita, Tomohiro Hirano, Kenichi Sakurai
We report a case of a simultaneous and ipsilateral multiple breast carcinoma.The patient was 35-year-old woman.She was noticed a breast lump on her right breast, and visited our hospital.Mammography showed a tumor accompanied by spiculation on her right breast.Ultrasonography revealed 2 tumors with irregular margins, 23mm in diameter and 12mm in diameter, and were observed on C area of her right breast.The continuity of the 2 tumors was not clear.Core needle biopsies for each breast tumors led to a diagnosis...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29629029/reactive-oxygen-species-dependent-apoptosis-induction-by-water-extract-of-citrus-unshiu-peel-in-mda-mb-231-human-breast-carcinoma-cells
#6
Min Yeong Kim, Eun Ok Choi, Hyun HwangBo, Da He Kwon, Kyu Im Ahn, Hong Jae Kim, Seon Yeong Ji, Su-Hyun Hong, Jin-Woo Jeong, Gi Young Kim, Cheol Park, Yung Hyun Choi
BACKGROUND/OBJECTIVES: Although several recent studies have reported the anti-cancer effects of extracts or components of Citrus unshiu peel, which has been used for various purposes in traditional medicine, the molecular mechanisms for their effects remain unclear. In the present study, the anti-cancer activity of a water-soluble extract of C. unshiu peel (WECU) in MDA-MB-231 human breast carcinoma cells at the level of apoptosis induction was investigated. MATERIALS/METHODS: Cytotoxicity was evaluated using the MTT assay...
April 2018: Nutrition Research and Practice
https://www.readbyqxmd.com/read/29595684/gastric-metastasis-from-invasive-lobular-breast-cancer-mimicking-primary-gastric-cancer-a-case-report
#7
Dae Hoon Kim, Seung-Myoung Son, Young Jin Choi
RATIONALE: Gastric metastasis from invasive lobular breast cancer is relatively rare, commonly presented among multiple metastases, several years after primary diagnosis of breast cancer. Importantly, gastric cancer that is synchronously presented with lobular breast cancer can be misdiagnosed as primary gastric cancer; therefore, accurate differential diagnosis is required. PATIENT CONCERNS: A 39-year-old woman was visited to our hospital because of right breast mass and progressive dyspepsia...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29594054/a-case-report-of-syndromic-multinodular-goitre-in-adolescence-exploring-the-phenotype-overlap-between-cowden-and-dicer1-syndromes
#8
Dorothée Bouron-Dal Soglio, Leanne de Kock, Richard Gauci, Nelly Sabbaghian, Elizabeth Thomas, Helen C Atkinson, Nicholas Pachter, Simon Ryan, John P Walsh, M Priyanthi Kumarasinghe, Karen Carpenter, Ayça Aydoğan, Colin J R Stewart, William D Foulkes, Catherine S Choong
Background: Hereditary tumour predisposition syndromes may increase the risk for development of thyroid nodules at a young age. We present the case of an adolescent female with Cowden syndrome who had some atypical phenotypic features which overlapped with the DICER1 syndrome. Material and Methods: A 17-year-old female presented with a 3-month history of progressive right neck swelling. Fine needle cytology of the thyroid revealed a follicular neoplasm with features suggestive of follicular variant of papillary thyroid carcinoma and she underwent a hemithyroidectomy...
January 2018: European Thyroid Journal
https://www.readbyqxmd.com/read/29543815/chronic-hepatitis-b-infection-and-non-hepatocellular-cancers-a-hospital-registry-based-case-control-study
#9
Jihyun An, Jong Woo Kim, Ju Hyun Shim, Seungbong Han, Chang Sik Yu, Jaewon Choe, Danbi Lee, Kang Mo Kim, Young-Suk Lim, Young-Hwa Chung, Yung Sang Lee, Dong Jin Suh, Jin Hyoung Kim, Han Chu Lee
BACKGROUND: Prior epidemiological evidences suggest that hepatitis B virus (HBV) infection is linked to cancers other than hepatocellular carcinoma. This prospective hospital registry-based case-control study aimed to investigate the sero-epidemiological association between chronic HBV infection and various types of cancer. METHODS: 95,034 patients with first-diagnosed non-hepatocellular malignancy in a tertiary hospital between 2007 and 2014; and 118,891 non-cancer individuals as controls from a health promotion center were included...
2018: PloS One
https://www.readbyqxmd.com/read/29525464/management-of-positive-margins-after-initial-lumpectomy-in-elderly-women-with-breast-cancer
#10
Fernando A Angarita, Sergio A Acuna, David R McCready, Jaime Escallon
INTRODUCTION: It is unknown whether the treatment disparity observed between young and elderly women extends to the management of positive margins after initial lumpectomy. The primary aim was to evaluate the management of positive margins after initial lumpectomy in elderly women. METHODS: Women ≥50 y who underwent lumpectomy for stage I-III tumors were identified. Tumor and treatment characteristics were collected across two subgroups: young (50-69 y) and elderly (≥70 y)...
February 21, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29493262/clinical-and-histological-features-of-second-breast-cancers-following-radiotherapy-for-childhood-and-young-adult-malignancy
#11
Charlotte Demoor-Goldschmidt, Stéphane Supiot, Marc-André Mahé, Odile Oberlin, Rodrigue Allodji, Nadia Haddy, Sylvie Helfre, Céline Vigneron, Victoire Brillaud-Meflah, Valérie Bernier, Anne Laprie, Anne Ducassou, Line Claude, Ibrahim Diallo, Florent de Vathaire
OBJECTIVE: The purpose of this study was to determine the characteristics of early second breast cancer (SBC) among survivors of childhood and young adult malignancy treated with irradiation. METHODS: We conducted a multicenter retrospective study of women who presented with breast cancer aged 50 years or younger in nine French centers. RESULTS: 121 patients and 141 SBC were analyzed (invasive = 130; non-invasive = 11). The mean age at first cancer diagnosis was 15 years and at initial SBC diagnosis was 38 years...
March 15, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29456469/prophylactic-surgery-for-whom-when-and-how
#12
REVIEW
Christine Mau, Michael Untch
Risk-reducing surgery has proved to be a reasonable procedure in healthy women with a definitely elevated risk of developing cancer. Here we consider the elevated risk of breast and ovarian cancer. There is a clear indication for such surgery in healthy women with a pathogenic BRCA1/2 mutation. For these patients, a risk-reducing bilateral mastectomy leads to a verifiable reduction in mortality from breast cancer, particularly for young patients. In most cases, surgery is combined with breast reconstruction...
December 2017: Breast Care
https://www.readbyqxmd.com/read/29453385/prediction-of-advanced-axillary-lymph-node-metastases-ypn2-3-using-breast-mr-imaging-and-pet-ct-after-neoadjuvant-chemotherapy-in-invasive-ductal-carcinoma-patients
#13
Won Hwa Kim, Sang-Woo Lee, Hye Jung Kim, Yee Soo Chae, Shin Young Jeong, Jin Hyang Jung, Ho Yong Park, Won Kee Lee
We aimed to investigate the value of breast magnetic resonance (MR) imaging and positron emission tomography-computed tomography (PET/CT) in predicting advanced axillary lymph node (ALN) metastases (ypN2-3) after neoadjuvant chemotherapy (NAC) in invasive ductal carcinoma patients. A total of 108 patients with invasive ductal carcinoma underwent breast MR imaging and PET/CT both before and after NAC (termed initial staging and restaging, respectively). The number of positive ALNs and the short diameter (SD) of the largest ALN on breast MR imaging and maximal standardized uptake value (SUVmax) in the ALNs on PET/CT were evaluated...
February 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29434947/association-between-inflammation-and-cancer-stem-cell-phenotype-in-breast-cancer
#14
Young Ju Jeong, Hoon Kyu Oh, Sung Hwan Park, Jin Gu Bong
Inflammation and cancer stem cells (CSCs) are becoming increasingly recognized as components of tumorigenesis in breast cancer. In the present study, the association between inflammation and BCSC phenotype was evaluated in human breast cancer tissue. Immunohistochemical staining for cluster of differentiation (CD)24, 44, 4, 8 and 68 was performed using tissue microarray blocks containing 47 consecutive cases of invasive breast carcinoma and 10 normal breast tissue samples. The levels of inflammatory modulators and cytokines, and intratumoral or peritumoral lymphocyte infiltration, were assessed...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29404301/adolescents-and-young-adults-a-study-of-distribution-of-cancer-at-ages-15-39-years-in-a-tertiary-care-hospital-from-north-india-epidemiological-considerations
#15
Neha Kakkar, Ajay Gupta, Neeraj Kumar Sharma, Prachi Agarwal, Jaspreet Kaur
Purpose: This study aimed to analyze cancer pattern among adolescents and young adults (AYA) in a tertiary care center in North India. Materials and Methods: A retrospective study from January 2011 to December 2014 was undertaken on AYA cancer patients (aged 15-39 years). Results: Totally 1077 cases of AYA cancers were identified for analyzing the frequency and pattern of cancer distribution. The most common cancer was head and neck (32%) followed by breast (14...
October 2017: South Asian Journal of Cancer
https://www.readbyqxmd.com/read/29398324/risk-factors-for-the-development-of-invasive-cancer-in-unresected-ductal-carcinoma-in-situ
#16
Anthony J Maxwell, Karen Clements, Bridget Hilton, David J Dodwell, Andrew Evans, Olive Kearins, Sarah E Pinder, Jeremy Thomas, Matthew G Wallis, Alastair M Thompson
BACKGROUND: The natural history of ductal carcinoma in situ (DCIS) remains uncertain. The risk factors for the development of invasive cancer in unresected DCIS are unclear. METHODS: Women diagnosed with DCIS on needle biopsy after 1997 who did not undergo surgical resection for ≥1 year after diagnosis were identified by breast centres and the cancer registry and outcomes were reviewed. RESULTS: Eighty-nine women with DCIS diagnosed 1998-2010 were identified...
April 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29396079/review-of-factors-influencing-women-s-choice-of-mastectomy-versus-breast-conserving-therapy-in-early-stage-breast-cancer-a-systematic-review
#17
REVIEW
Jeffrey Gu, Gary Groot, Catherine Boden, Angela Busch, Lorraine Holtslander, Hyun Lim
We have performed a narrative synthesis. A literature search was conducted between January 2000 and June 2014 in 7 databases. The initial search identified 2717 articles; 319 underwent abstract screening, 67 underwent full-text screening, and 25 final articles were included. This review looked at early stage breast cancer in women only, excluding ductal carcinoma in situ and advanced breast cancer. A conceptual framework was created to organize the central constructs underlying women's choices: clinicopathologic factors, physician factors, and individual factors with subgroups of sociodemographic, geographic, and personal beliefs and preferences...
January 3, 2018: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29394219/multimodality-imaging-findings-of-metaplastic-breast-carcinomas-a-report-of-five-cases
#18
Hyun Jeong Kim, Shin Young Kim, Sun Huh
Metaplastic carcinoma is a rare subtype of breast cancer that comprises histologically diverse malignancies. Metaplastic carcinoma tends to have an aggressive clinical presentation, high metastatic potential, and more chances of local recurrence, as compared with intraductal carcinoma. Although many clinical and pathologic finding have been reported, to our knowledge, there are few reports of imaging findings for this type of tumor.In this study, we reviewed data of 5 patients with histopathologically proven metaplastic breast carcinoma...
February 1, 2018: Ultrasound Quarterly
https://www.readbyqxmd.com/read/29391087/percutaneous-needle-biopsies-of-the-breast-in-women-younger-than-35-years-minimally-or-excessively-invasive
#19
Aida Abou-Zamzam, Scott Somers, Cherie Cora, Seyed Pairawan, Sharon Lum
Percutaneous needle biopsy (PNB) of the breast is commonly used for diagnosis of breast pathology, but has been less studied in young women. We sought to determine the effectiveness and necessity of PNB in patients younger than 35 years of age. The charts of sequential patients <35 years who underwent PNB between February 2013 and May 2016 were reviewed; 181 PNB were performed in 127 patients. Median age was 30 years (13-34). Indications for PNB were Breast Imaging Reporting and Data System (BIRADS) ≥4 in 137 (75...
October 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/29390502/male-occult-breast-cancer-with-axillary-lymph-node-metastasis-as-the-first-manifestation-a-case-report-and-literature-review
#20
REVIEW
Ruixin Xu, Jianbin Li, Yingjie Zhang, Hongbiao Jing, Youzhe Zhu
RATIONALE: Occult breast cancer (OBC) is extremely rare in males with neither symptoms in the breast nor abnormalities upon imaging examination. PATIENT CONCERNS: This current case report presents a young male patient who was diagnosed with male OBC first manifesting as axillary lymph node metastasis. The physical and imaging examination showed no primary lesions in either breasts or in other organs. DIAGNOSES: The pathological results revealed infiltrating ductal carcinoma in the axillary lymph nodes...
December 2017: Medicine (Baltimore)
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