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https://www.readbyqxmd.com/read/29342360/sustained-delivery-of-doxorubicin-via-acetalated-dextran-scaffold-prevents-glioblastoma-recurrence-after-surgical-resection
#1
Elizabeth G Graham-Gurysh, Kathryn M Moore, Andrew B Satterlee, Kevin T Sheets, Feng-Chang Lin, Eric M Bachelder, C Ryan Miller, Shawn Hingtgen, Kristy M Ainslie
The primary cause of mortality for glioblastoma (GBM) is local tumor recurrence following standard-of-care therapies, including surgical resection. With most tumors recurring near the site of surgical resection, local delivery of chemotherapy at the time of surgery is a promising strategy. Herein drug loaded polymer scaffolds with two distinct degradation profiles were fabricated to investigate the effect of local drug delivery rate on GBM recurrence following surgical resection. The novel biopolymer, acetalated dextran (Ace-DEX), was compared to commercially available polyester, poly(L-lactide) (PLA)...
January 17, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29342262/preliminary-study-of-1940-nm-thulium-laser-usage-in-peroral-endoscopic-myotomy-for-achalasia
#2
J Liu, Y Jiao, Y Niu, L Yu, M Ji, S Zhang
Esophageal achalasia is a type of motility disorder characterized by incomplete relaxation of lower esophageal sphincter (LES) and absence of esophageal peristalsis. Peroral endoscopic myotomy (POEM) is a new treatment option for achalasia that is less invasive, more effective, and safe as compared to surgery. High-frequency electrotome is commonly used in POEM, but takes longer time to make the tunnel in the esophagus and causes many complications. The thulium laser decreases the risk of bleeding and perforation in endoscopy but has not been reported in digestive diseases, especially in POEM...
January 9, 2018: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29342012/diffuse-chorioretinopathy-without-serous-detachment-associated-with-cardiac-transplantation
#3
Michael F Marmor
PURPOSE: To analyze an unusual case of widespread chorioretinopathy after cardiac transplantation for its potential etiology and clinical significance. METHODS: Clinical examinations included widefield and macular color and fundus autofluorescence photography, spectral domain optical coherence tomography, fluorescein angiography and indocyanine green angiography, full-field electroretinography, and Goldmann visual fields. PATIENT: A 44-year-old Hispanic woman was referred to rule out retinitis pigmentosa...
January 16, 2018: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29341954/carbapenemase-production-of-clinical-isolates-acinetobacter-baumannii-and-pseudomonas-aeruginosa-from-a-bulgarian-university-hospital
#4
Atanaska P Petrova, Irina D Stanimirova, Ivan N Ivanov, Michael M Petrov, Tsonka M Miteva-Katrandzhieva, Vasil I Grivnev, Velichka S Kardjeva, Todor V Kantardzhiev, Mariana A Murdjeva
BACKGROUND: Production of Bla OXA-23, OXA-24, OXA-58 and hyperexpression of OXA-51 due to ISAba1 insertion sequence are the leading causes of carbapenem resistance in Acinetobacter baumannii. The loss of OprD transmembrane protein and the overexpression of some effl ux pumps are considered to be the main factors for carbapenem resistance in Pseudomonas aeruginosa whereas metallo-enzymes' production has a secondary role. AIM: Тo examine the carbapenem resistance due to carbapenemase production among clinically signifi cant Gram-negative non-fermenters from St George University hospital, Plovdiv: A...
December 20, 2017: Folia Medica
https://www.readbyqxmd.com/read/29341874/validation-of-an-icd-code-for-accurately-identifying-emergency-department-patients-who-suffer-an-out-of-hospital-cardiac-arrest
#5
Shelby K Shelton, Steve B Chukwulebe, David F Gaieski, Benjamin S Abella, Brendan G Carr, Sarah M Perman
AIM: International classification of disease (ICD-9) code 427.5 (cardiac arrest) is utilized to identify cohorts of patients who suffer out-of-hospital cardiac arrest (OHCA), though the use of ICD codes for this purpose has never been formally validated. We sought to validate the utility of ICD-9 code 427.5 by identifying patients admitted from the emergency department (ED) after OHCA. METHODS: Adult visits to a single ED between January 2007 and July 2012 were retrospectively examined and a keyword search of the electronic medical record (EMR) was used to identify patients...
January 13, 2018: Resuscitation
https://www.readbyqxmd.com/read/29341845/outside-in-inside-out-creating-focus-on-the-patient-a-vaccine-company-perspective
#6
Denis Sohy, Isabelle Dusart, Philibert Goulet, Diane Visy, Luc Gasthuys, Tatjana Poplazarova, Thomas Breuer, Norman Begg
Involving patients in the development of medicines and vaccines should result in benefits to patients. The vaccine recipient is usually a healthy person. We describe the rationale and implementation of a vaccine company's initiative to encourage employees to identify with patients of the conditions prevented by the vaccines they help to produce. The Voice of the Patient ("VoP"), begun in 2014, is an educational programme directed at the 16,000 employees of a global vaccine company. It engages employees through an understanding that they are all "vaccine patients", and that they can make a difference by considering the impact of decisions made in their day to day work...
January 17, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29341788/specific-airway-resistance-is-a-better-outcome-parameter-in-bronchial-provocation-testing-compared-to-fev1-in-patients-with-bronchial-asthma
#7
S A van Nederveen-Bendien, J Vahl, H G M Heijerman
OBJECTIVES: Asthma is a chronic inflammatory disease characterized by airway hyperresponsiveness (AHR). A bronchial provocation test (BPT) is used to test for AHR. However forced expiratory volume in one second (FEV1), used as outcome parameter is effort-related, in contrast to specific airway resistance (sRaw). This research was conducted to provide insight in the usefulness of sRaw as an outcome parameter in BPT. METHODS: A total of 85 patients performing a BPT were included in the study...
January 17, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29341529/-when-the-ward-overflows%C3%A2-the-impact-of-outlying-beds-on-patient-care
#8
Valérie Mosimann, Olivier Lamy, Julien Castioni
Due to the chronic lack of beds in hospitals, patients are often hospitalized in other departments (outlier patients), with a responsible physician working in another department. This causes increased thromboembolics risks, nosocomial infections, falls and delirium in the elderly, morbidity and mortality. Outlier patients, compared to standard patients, stay longer in the emergency department and their discharge documents are available later. Outlying is used daily in the CHUV hospital and new strategies are elaborated to manage patient flow, especially during the flu epidemic...
January 17, 2018: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29341503/tadalafil-5-mg-once-daily-improves-lower-urinary-tract-symptoms-and-erectile-dysfunction-a-systematic-review-and-meta-analysis
#9
Yilin Wang, Yiping Bao, Jie Liu, Lijun Duan, Yuanshan Cui
OBJECTIVES: We carried out a systematic review and meta-analysis to assess tadalafil 5 mg once-daily for the treatment of lower urinary tract symptoms (LUTS) and erectile dysfunction (ED). METHODS: A literature review was performed to identify all published randomized double-blind, placebo-controlled trials of tadalafil 5 mg once-daily for the treatment of LUTS and ED. The search included the following databases: MEDLINE, EMBASE, and the Cochrane Controlled Trials Register...
January 2018: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/29341502/advances-in-intravesical-therapy-for-bladder-pain-syndrome-bps-interstitial-cystitis-ic
#10
REVIEW
En Meng, Yu-Chao Hsu, Yao-Chi Chuang
Bladder pain syndrome (BPS)/interstitial cystitis (IC) is a chronic symptom complex that may cause bothersome storage symptoms and pain or discomfort of the bladder, adversely affecting a patient's quality of life. The etiology of IC/BPS remains unclear, and its cause may be multifactorial. Diagnosis of IC/BPS is based on clinical features, and the possibility of other conditions must be ruled out first. Although no definitive treatment is currently available for IC/BPS, various intravesical therapies are used for IC/BPS, including heparin, hyaluronic acid, chondroitin sulfate, pentosan polysulfate, dimethylsulfoxide, liposomes, and botulinum onabotulinumtoxinA (BoNT-A)...
January 2018: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/29341487/identification-of-stress-related-microrna-biomarkers-in-type-2-diabetes-a-systematic-review-and-meta-analysis
#11
Yingzhi Liang, Li Jiajianghui, Huanbo Xiao, Yan He, Ling Zhang, Yuxiang Yan
BACKGROUND: Many studies have investigated miRNAs in the detection of type 2 diabetes mellitus (T2DM). Here, the dysregulated direction of stress-related miRNAs that used as biomarkers of T2DM was summarized and analyzed. METHODS: PubMed, EMBASE, ISI web of science and three Chinese databases were searched for case-control miRNA profiling studies about T2DM. A meta-analysis under a random effect was performed. Subgroup analysis was conducted based on different tissues and species, respectively...
January 17, 2018: Journal of Diabetes
https://www.readbyqxmd.com/read/29341459/multicenter-study-of-diagnostic-procedures-genetic-aberration-analysis-and-first-line-treatment-of-lung-cancer-in-jiangsu-province-china
#12
YangBo Hu, Huan Hu, LiYun Miao, Xin Zhao, Wei Gu, Wei Heng, ZiLi Meng, Jian Feng, Yi You, XingXiang Xu, Rong Hu, HaiQuan Li, Jie Zhao, XiaoLi Zhu, MeiQi Shi, Li Shen, XiuWei Zhang, XiaoWei Yin, Hang Ma, MinHua Shi, Yong Yu, Hong Lv, LiMing Cai, GaoHua Feng, YeQing Zhang, Feng Wu, TangFeng Lv, Yong Song
BACKGROUND: Jiangsu Province, China, is highly developed economically and culturally, and has a high prevalence of lung cancer. We aimed to evaluate the diagnostic procedures, genetic aberration analysis status, and first-line treatment models of lung cancer in Jiangsu Province. METHODS: Lung cancer patients diagnosed in 2016 at 22 tertiary care hospitals were evaluated. Demographic characteristics, tumor histology, staging, family history of lung cancer, auxiliary examinations, genetic testing, and first-line treatment were collected on discharge...
January 17, 2018: Thoracic Cancer
https://www.readbyqxmd.com/read/29341413/effects-of-health-insurance-coverage-on-risky-behaviors
#13
Jungtaek Lee
Prior to implementation of the Patient Protection and Affordable Care Act, dependent health insurance coverage was typically available only for young adults under the age of 19. As of September 2010, the Affordable Care Act extended dependent health insurance coverage to include young adults up to the age of 26. I use the National Health Interview Survey for the sample period from 2011 to 2013 to analyze the causal relationship between the expansion of dependent coverage and risky behaviors including smoking and drinking as well as preventive care...
January 17, 2018: Health Economics
https://www.readbyqxmd.com/read/29341326/elevated-leukocyte-count-in-cerebrospinal-fluid-of-patients-with-chronic-inflammatory-demyelinating-polyneuropathy
#14
Ilse M Lucke, Stojan Peric, Gwen G A van Lieverloo, Luuk Wieske, Camiel Verhamme, Ivo N van Schaik, Ivana Basta, Filip Eftimov
Cerebrospinal fluid (CSF) examination is often part of the diagnostic work-up of a patient suspected of having chronic inflammatory demyelinating polyneuropathy (CIDP). According to the EFNS/PNS criteria, an elevated protein level without pleocytosis (leukocytes <10 cells/μl) is supportive of the diagnosis CIDP. It is unclear how many CSF leukocytes are compatible with the diagnosis CIDP and how extensive the diagnostic work-up should be in patients with a demyelinating neuropathy and pleocytosis. We performed a retrospective study at two tertiary neuromuscular referral clinics and identified 14 out of 273 (6%) patients with CIDP with elevated CSF leukocytes (≥10 cells/μl)...
January 17, 2018: Journal of the Peripheral Nervous System: JPNS
https://www.readbyqxmd.com/read/29341323/test-retest-reliability-and-longitudinal-analysis-of-automated-hippocampal-subregion-volumes-in-healthy-ageing-and-alzheimer-s-disease-populations
#15
Amanda Worker, Danai Dima, Anna Combes, William R Crum, Johannes Streffer, Steven Einstein, Mitul A Mehta, Gareth J Barker, Steve C R Williams, Owen O'daly
The hippocampal formation is a complex brain structure that is important in cognitive processes such as memory, mood, reward processing and other executive functions. Histological and neuroimaging studies have implicated the hippocampal region in neuropsychiatric disorders as well as in neurodegenerative diseases. This highly plastic limbic region is made up of several subregions that are believed to have different functional roles. Therefore, there is a growing interest in imaging the subregions of the hippocampal formation rather than modelling the hippocampus as a homogenous structure, driving the development of new automated analysis tools...
January 16, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29341300/inflammatory-and-related-biomarkers-are-associated-with-post-transplant-diabetes-mellitus-in-kidney-recipients
#16
Torbjørn F Heldal, Thor Ueland, Trond Jenssen, Anders Hartmann, Anna V Reisaeter, Pål Aukrust, Annika Michelsen, Anders Åsberg
In this study we investigate the association between selected inflammatory related biomarkers and post transplant hyperglycemia in kidney transplant recipients. This retrospective analysis comprises 852 patients receiving a kidney transplant at the Norwegian national transplant centre between 2007 and 2012, all having a normal oral glucose tolerance test (OGTT) before transplantation. A diagnostic OGTT was performed 10 weeks post-transplant to examine the association between inflammation related biomarkers and two-hour plasma glucose (2HPG) by multivariable linear regression models adjusting for BMI, age, graft function, fasting insulin levels, dosage of prednisolone, and concentration of calcineurin inhibitors...
January 16, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29341131/a-retrospective-study-of-feline-trauma-patients-admitted-to-a-referral-centre
#17
T Hernon, M Gurney, S Gibson
OBJECTIVE: To identify prognostic information and provide recommendations for management of feline trauma patients. METHODS: Retrospective analysis of case records for 185 cats presented as emergency trauma cases to a referral hospital between February 2009 and December 2013. Each case was assigned a severity score from 1 (very minor injuries) to 6 (moribund, dying). The data were analysed using Mann-Whitney U and Spearman's rank correlation tests. Logistic regression was used to calculate odds ratios...
January 17, 2018: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/29341105/metabolomic-characterization-of-human-hippocampus-from-drug-resistant-epilepsy-with-mesial-temporal-seizure
#18
Julien Detour, Caroline Bund, Charles Behr, Hélène Cebula, Ercument A Cicek, Maria-Paola Valenti-Hirsch, Béatrice Lannes, Benoît Lhermitte, Astrid Nehlig, Pierre Kehrli, François Proust, Edouard Hirsch, Izzie-Jacques Namer
OBJECTIVE: Within a complex systems biology perspective, we wished to assess whether hippocampi with established neuropathological features have distinct metabolome. Apparently normal hippocampi with no signs of sclerosis (noHS), were compared to hippocampal sclerosis (HS) type 1 (HS1) and/or type 2 (HS2). Hippocampus metabolome from patients with epilepsy-associated neuroepithelial tumors (EANTs), namely, gangliogliomas (GGs) and dysembryoplastic neuroepithelial tumors (DNTs), was also compared to noHS epileptiform tissue...
January 17, 2018: Epilepsia
https://www.readbyqxmd.com/read/29341034/therapeutic-assessment-of-vulvar-squamous-intraepithelial-lesions-with-co2-laser-vaporization-in-immunosuppressed-patients
#19
Julisa Chamorro Lascasas Ribalta, Mariana Vendramin Mateussi, Neila Maria de Góis Speck
OBJECTIVE:  A vulvar squamous intraepithelial lesion is deemed to be a preceding lesion to vulvar cancer, especially in women aged under 40 years, holders of an acquired or idiopathic immunosuppression. Several treatments have been used to treat these lesions. One of the aesthetically acceptable therapeutic methods is the CO2 laser vaporization. METHODS:  In a transversal study, 46 records of immunosuppressed women bearing a vulvar low grade and/or high grade squamous intraepithelial lesion were selected out of the retrospective analysis, computing age, date of record, date of vulvar lesion treatment with CO2 laser, the time elapsed between the first and the last visit (in months), the number of visits, the presence or absence of condylomatous lesions in other female lower genital tract sites and whether or not recurrences and persistence of intraepithelial lesions have been noticed during the follow-up...
January 2018: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/29340850/drug-related-problems-among-community-dwelling-older-adults-in-mainland-china
#20
Jiadan Yang, Long Meng, Yu Liu, Liping Lv, Shusen Sun, Rui Long, Xuefeng Shan, Jie Song, Feng Qiu
Background Little is known about the extent of drug-related problems (DRPs) in community-dwelling older adult patients with chronic diseases in mainland China. Setting A medication therapy review service at a community health center in Chongqing, China. Objective To identify and categorize DRPs along with pharmacists' recommendations in addressing the DRPs identified. Method The study was conducted between May 2015 and July 2016. A total of 102 community-dwelling older adults were included. MTR was carried out by clinical pharmacists...
January 16, 2018: International Journal of Clinical Pharmacy
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