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arthur weyman

Aidan Flynn, Qian Li, Marcello Panagia, Amr Abdelbaky, Megan MacNabb, Anthony Samir, Aaron M Cypess, Arthur E Weyman, Ahmed Tawakol, Marielle Scherrer-Crosbie
BACKGROUND: Brown adipose tissue (BAT) consumes glucose when it is activated by cold exposure, allowing its detection in humans by (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET) with computed tomography (CT). The investigators recently described a novel noninvasive and nonionizing imaging method to assess BAT in mice using contrast-enhanced ultrasound (CEUS). Here, they report the application of this method in healthy humans. METHODS: Thirteen healthy volunteers were recruited...
October 2015: Journal of the American Society of Echocardiography
Lin Wang, Timothy C Tan, Elkan F Halpern, Tomas G Neilan, Sanjeev A Francis, Michael H Picard, Hongwen Fei, Ephraim P Hochberg, Jeremy S Abramson, Arthur E Weyman, Irene Kuter, Marielle Scherrer-Crosbie
Anthracyclines are an important component of cancer treatments; however, their use is limited by the occurrence of cardiotoxicity. There are limited data on the occurrence of heart failure and the value of baseline and follow-up measurements of left ventricular (LV) ejection fraction (EF) in the current era. Therefore, the objectives of the present study were twofold: (1) to characterize the occurrence of and risk factors for major adverse cardiac events (MACEs: symptomatic heart failure and cardiac death) in a large contemporaneous population of adult patients treated with anthracyclines and (2) to test the value of LVEF and LV dimensions obtained using echocardiography in the prediction of MACE...
August 1, 2015: American Journal of Cardiology
Maria Carmo P Nunes, Timothy C Tan, Sammy Elmariah, Rodrigo do Lago, Ronan Margey, Ignacio Cruz-Gonzalez, Hui Zheng, Mark D Handschumacher, Ignacio Inglessis, Igor F Palacios, Arthur E Weyman, Judy Hung
BACKGROUND: Current echocardiographic scoring systems for percutaneous mitral valvuloplasty (PMV) have limitations. This study examined new, more quantitative methods for assessing valvular involvement and the combination of parameters that best predicts immediate and long-term outcome after PMV. METHODS AND RESULTS: Two cohorts (derivation n=204 and validation n=121) of patients with symptomatic mitral stenosis undergoing PMV were studied. Mitral valve morphology was assessed by using both the conventional Wilkins qualitative parameters and novel quantitative parameters, including the ratio between the commissural areas and the maximal excursion of the leaflets from the annulus in diastole...
February 25, 2014: Circulation
Donald C Harrison, Michel A Ibrahim, Arthur E Weyman, Lewis H Kuller, William J Blot, David E Miller
The 20-year activities of a medical supervisory panel appointed under the terms of a settlement agreement of the Bowling v. Pfizer class action suit involving the Björk-Shiley convexo-concave (BSCC) heart valve are detailed. Of approximately 86,000 valves implanted, catastrophic failure of the valve was reported in 663 patients from 1978 to 2012. In 1994, a 7-member medical panel consisting of cardiologists, cardiovascular surgeons, epidemiologists, and a nontechnical chairman was appointed by the federal court...
December 15, 2013: American Journal of Cardiology
Arthur E Weyman
No abstract text is available yet for this article.
January 2013: JACC. Cardiovascular Imaging
Rory B Weiner, Arthur E Weyman, Jonathan H Kim, Thomas J Wang, Michael H Picard, Aaron L Baggish
Left ventricular (LV) rotation occurs due to contraction of obliquely oriented myocardial fibres. Left ventricular twist (LVT) results from rotation of the apex and base in opposite directions. Although LVT is altered in various cardiac diseases, physiological factors that affect LVT remain incompletely understood. Isometric handgrip testing (IHGT), a well-established laboratory-based technique to increase LV afterload, was performed for 3 min at 40% maximum force generation in healthy human subjects (n = 18, mean age 29...
October 15, 2012: Journal of Physiology
François Tournoux, Jagmeet P Singh, Raymond C Chan, Annabel Chen-Tournoux, David McCarty, Robert Manzke, Jeremy N Ruskin, Marc Semigran, E Kevin Heist, Stephanie Moore, Michael H Picard, Arthur E Weyman
AIMS: Current imaging techniques attempt to identify responders to cardiac resynchronization therapy (CRT). However, because CRT response may depend upon several factors, it may be clinically more useful to identify patients for whom CRT would not be beneficial even under optimal conditions. We aimed to determine the negative predictive value of a composite echocardiographic index evaluating atrial-ventricular dyssynchrony (AV-DYS) and intraventricular dyssynchrony. METHODS AND RESULTS: Subjects with standard indications for CRT underwent echo before and during the month following device implantation...
January 2012: European Heart Journal Cardiovascular Imaging
Arthur E Weyman
No abstract text is available yet for this article.
June 2011: JACC. Cardiovascular Imaging
Kibar Yared, Peter Noseworthy, Arthur E Weyman, Elizabeth McCabe, Michael H Picard, Aaron L Baggish
BACKGROUND: Transthoracic echocardiographic estimates of peak systolic pulmonary artery pressure are conventionally calculated from the maximal velocity of the tricuspid regurgitation (TR) jet. Unfortunately, there is insufficient TR to determine estimated peak systolic pulmonary artery pressure (EPSPAP) in a significant number of patients. To date, in the absence of TR, no noninvasive method of deriving EPSPAP has been developed. METHODS: Five hundred clinically indicated transthoracic echocardiograms were reviewed over a period of 6 months...
June 2011: Journal of the American Society of Echocardiography
Arthur E Weyman
No abstract text is available yet for this article.
December 7, 2010: Journal of the American College of Cardiology
Rory B Weiner, Adolph M Hutter, Francis Wang, Jonathan Kim, Arthur E Weyman, Malissa J Wood, Michael H Picard, Aaron L Baggish
OBJECTIVES: We sought to examine the effect of endurance exercise training (EET) on peak systolic left ventricular torsion (LVT) and peak early diastolic untwisting rate (UTR). BACKGROUND: Left ventricular (LV) structural adaptations to EET have been well characterized. LVT, a recognized marker of LV function in numerous cardiac diseases, has recently been investigated in the setting of exercise. However, longitudinal data characterizing the impact of sustained exercise training on LVT have not been reported...
October 2010: JACC. Cardiovascular Imaging
Rory B Weiner, Arthur E Weyman, Abigail May Khan, Jason S Reingold, Annabel A Chen-Tournoux, Marielle Scherrer-Crosbie, Michael H Picard, Thomas J Wang, Aaron L Baggish
BACKGROUND: left ventricular (LV) rotation results from contraction of obliquely oriented myocardial fibers. The net difference between systolic apical counterclockwise rotation and basal clockwise rotation is left ventricular torsion (LVT). Although LVT is altered in various cardiac diseases, determinants of LVT are incompletely understood. METHODS AND RESULTS: LV end-diastolic volume, LV apical and basal rotation, peak systolic LVT, and peak early diastolic untwisting rate were measured by speckle-tracking echocardiography in healthy subjects (n=8) before and after infusion of a weight-based normal saline bolus (2...
November 2010: Circulation. Cardiovascular Imaging
Aaron L Baggish, Charles S Fulco, Stephen Muza, Paul B Rock, Beth Beidleman, Allen Cymerman, Kibar Yared, Peter Fagenholz, David Systrom, Malissa J Wood, Arthur E Weyman, Michael H Picard, N Stuart Harris
Staged ascent (SA), temporary residence at moderate altitude en route to high altitude, reduces the incidence and severity of noncardiopulmonary altitude illness such as acute mountain sickness. To date, the impact of SA on pulmonary arterial pressure (PAP) is unknown. We tested the hypothesis that SA would attenuate the PAP increase that occurs during rapid, direct ascent (DA). Transthoracic echocardiography was used to estimate mean PAP in 10 healthy males at sea level (SL, P(B) approximately 760 torr), after DA to simulated high altitude (hypobaric chamber, P(B) approximately 460 torr), and at 2 times points (90 min and 4 days) during exposure to terrestrial high altitude (P(B) approximately 460 torr) after SA (7 days, moderate altitude, P(B) approximately 548 torr)...
2010: High Altitude Medicine & Biology
François Tournoux, Raymond C Chan, Robert Manzke, Mark D Hanschumacher, Annabel A Chen-Tournoux, Olivier Gérard, Jorge Solis-Martin, E Kevin Heist, Pascal Allain, Vivek Reddy, Jeremy N Ruskin, Arthur E Weyman, Michael H Picard, Jagmeet P Singh
No abstract text is available yet for this article.
January 2010: European Journal of Heart Failure
Daniel M Thys
Cardiac anesthesiology has evolved spectacularly over the past 30 yr, changing from a practice focused on the anesthetic management of patients with cardiovascular diseases to a practice of cardiovascular medicine that contributes to the medical and surgical management of cardiovascular patients. The second Weyman lecture reviews this history, the critical role of the Society of Cardiovascular Anesthesiologists in the evolution of the specialty, and the prospects for continued development for the specialty, the society, and the patients they care for...
December 2009: Anesthesia and Analgesia
Arthur E Weyman
No abstract text is available yet for this article.
April 28, 2009: Journal of the American College of Cardiology
Arthur E Weyman
Future developments in echocardiography will likely focus on the continued evolution of existing techniques, such as real-time 3-dimensional (RT3D) imaging and contrast-enhanced imaging; higher resolution imaging; and greater flexibility in imaging systems due to miniaturization, enhanced connectivity, and integration with other techniques. Improvements in RT3D image quality may include expanded parallel processing and use of transesophageal matrix arrays. Two areas of future clinical potential for contrast-enhanced echocardiography/ultrasound are the use of targeted microbubbles for diagnostic and therapeutic applications and expanded vascular imaging...
2009: Reviews in Cardiovascular Medicine
Pamela S Douglas, Arthur E Weyman, Jonathan R Lindner, Kevin Wei
No abstract text is available yet for this article.
January 2008: JACC. Cardiovascular Imaging
Cynthia C Taub, Joan M Stoler, Teresa Perez-Sanz, John Chu, Eric M Isselbacher, Michael H Picard, Arthur E Weyman
BACKGROUND: The echocardiographic features of mitral valve prolapse (MVP) in Marfan syndrome have been well described, and the incidence of MVP in Marfan syndrome is reported to be 40-80%. However, most of the original research was performed in the late 1980s and early 1990s, when the diagnostic criteria for MVP were less specific. Our goal was to investigate the characteristics of MVP associated with Marfan syndrome using currently accepted diagnostic criteria for MVP. METHODS: Between January 1990 and March 2004, 90 patients with definitive diagnosis of Marfan syndrome (based on standardized criteria with or without genetic testing) were referred to Massachusetts General Hospital for transthoracic echocardiography...
April 2009: Echocardiography
François Tournoux, Raymond C Chan, Mark D Handschumacher, Ivan S Salgo, Robert Manzke, Scott Settlemier, J Luis Guerrero, Ricardo C Cury, Arthur E Weyman, Michael H Picard
BACKGROUND: The aim of this study was to test the ability of a new algorithm to accurately measure point-to-point Lagrangian strain (LS) and local rotation (ROT). Change in distance between 2 separate regions of interest (ROIs) can theoretically be computed with speckle tracking (SpT) and used to calculate LS in any tissue location with angle independence and high spatial resolution. Similarly, tracking an ROI relative to a fixed point should provide an estimate of ROT. METHODS: Two dynamic phantoms (60 beats/min) were scanned in short axis at frame rates of 30, 60, and 90 Hz...
October 2008: Journal of the American Society of Echocardiography
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