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https://www.readbyqxmd.com/read/29334604/breast-conservation-therapy-versus-mastectomy-in-patients-with-t1-2n1-triple-negative-breast-cancer-pooled-analysis-of-krog-14-18-and-14-23
#1
Kyubo Kim, Hae Jin Park, Kyung Hwan Shin, Jin Ho Kim, Doo Ho Choi, Won Park, Seung Do Ahn, Su Ssan Kim, Dae Yong Kim, Tae Hyun Kim, Jin Hee Kim, Jiyoung Kim
Purpose: The aim of this study is to compare the treatment outcomes of breast conserving surgery (BCS) plus radiotherapy (RT) vs. mastectomy for patients with pT1-2N1 triple negative breast cancer (TNBC). Methods: Using two multicenter retrospective studies on breast cancer, a pooled analysis was performed among 320 patients with pT1-2N1 TNBC. All patients who underwent BCS (n=212) received whole breast RT with or without regional nodal RT, while none who underwent mastectomy (n=108) received it...
January 8, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/29333403/treatment-outcomes-of-dose-attenuated-chop-chemotherapy-in-elderly-patients-with-peripheral-t-cell-lymphoma
#2
Eun-Ji Choi, Jung Yong Hong, Dok Hyun Yoon, Jihoon Kang, Chan-Sik Park, Jooryung Huh, Eun Jin Chae, Yoonse Lee, Jin-Sook Ryu, Cheolwon Suh
Background: While cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP) is the most commonly used chemotherapeutic regimen for patients with peripheral T-cell lymphomas (PTCLs), elderly patients are more vulnerable to associated toxicities. We evaluated the efficacy and safety of dose-attenuated CHOP in elderly patients with PTCL. Methods: Patients with PTCL aged >70 years or 65-70-years with comorbidities were treated with dose-attenuated CHOP (cyclophosphamide: 562...
December 2017: Blood Research
https://www.readbyqxmd.com/read/29325763/clinical-experience-with-three-dimensional-printing-techniques-in-orthopedic-trauma
#3
Ji Wan Kim, Yongkoo Lee, Joonho Seo, Jai Hyung Park, Yong Min Seo, Sung Soo Kim, Hyun Chul Shon
BACKGROUND: To report our experiences with the use of three-dimensional (3D) printing in the field of orthopedic trauma. METHODS: This retrospective study enrolled 24 patients from three university teaching hospitals in whom 3D printing technique was applied: 14 patients with acetabular fractures and 10 patients with clavicular shaft fractures. We summarized our experiences with 3D printed bone models. RESULTS: Three-dimensional printed acetabular models improved understanding of complex acetabular anatomy and fracture pattern to plan the optimal positioning of a reduction clamp and the trajectory of screws...
January 8, 2018: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/29315741/association-between-allergic-diseases-and-ophthalmologic-diseases-including-cataracts-and-glaucoma-using-the-korean-national-health-and-nutrition-examination-survey-2010-2012-a-strobe-compliant-article
#4
Young Bok Lee, Ji Hyun Lee, Min Ji Kang, Jin Young Choi, Jin-Wou Kim, Dong Soo Yu, Kyung Do Han, Yong Gyu Park
This study investigated the association between allergic diseases and comorbid ophthalmologic diseases. We enrolled 14 776 participants who were at least 19 years of age. Multiple logistic regression analyses were used to evaluate the odds ratios for cataracts and glaucoma according to the presence of allergic diseases. Atopic dermatitis was not associated with the development of cataracts and glaucoma. However, asthma and allergic rhinitis were significantly associated with cataracts (hazard ratio [HR] = 1...
January 4, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/29312731/does-oxygen-therapy-increase-the-resolution-rate-of-primary-spontaneous-pneumothorax
#5
Chan Beom Park, Mi Hyoung Moon, Hyun Woo Jeon, Deog Gon Cho, Sun Wha Song, Yoo Dong Won, Yong Hwan Kim, Young-Du Kim, Seong Cheol Jeong, Kyung Soo Kim, Si Young Choi
Background: Patients with small pneumothoraces are usually treated with oxygen therapy. However, evidence that oxygen therapy increases resolution rate is based on small populations with secondary spontaneous pneumothorax. Therefore, this study aimed to confirm whether oxygen therapy increases the resolution rate of primary spontaneous pneumothorax (PSP). Methods: We retrospectively reviewed records of patients with PSP who had undergone outpatient observation (room air group) and those who were admitted for oxygen therapy (O2 group) between March 2005 and February 2016...
December 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29312705/anemia-as-a-clinical-marker-of-stable-chronic-obstructive-pulmonary-disease-in-the-korean-obstructive-lung-disease-cohort
#6
Yeon-Mok Oh, Joo Hun Park, Eun-Kyung Kim, Sung Chul Hwang, Hyun Ji Kim, Dae Ryong Kang, Kwang Ha Yoo, Ji-Hyun Lee, Tae-Hyung Kim, Seong Yong Lim, Chin Kook Rhee, Hyoung Kyu Yoon, Sang Yeub Lee, Sang-Do Lee
Background: Anemia is a major co-morbidity in chronic obstructive pulmonary disease (COPD). However, the mechanism of development for anemia and the impact of anemia on the prognosis of COPD remain poorly understood. Therefore, this study attempted to evaluate the prognostic role of anemia on the clinical course of COPD and investigate the factors linked with the serum hemoglobin level in COPD. Methods: We analyzed 407 COPD patients enrolled in the Korean obstructive lung disease (KOLD) cohort at 16 hospitals in Korea recruited over 9 years...
December 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29311579/structural-basis-for-the-enhanced-anti-diabetic-efficacy-of-lobeglitazone-on-ppar%C3%AE
#7
Jun Young Jang, Hwan Bae, Yong Jae Lee, Young Il Choi, Hyun-Jung Kim, Seung Bum Park, Se Won Suh, Sang Wan Kim, Byung Woo Han
Peroxisome proliferator-activated receptor γ (PPARγ) is a member of the nuclear receptor superfamily. It functions as a ligand-activated transcription factor and plays important roles in the regulation of adipocyte differentiation, insulin resistance, and inflammation. Here, we report the crystal structures of PPARγ in complex with lobeglitazone, a novel PPARγ agonist, and with rosiglitazone for comparison. The thiazolidinedione (TZD) moiety of lobeglitazone occupies the canonical ligand-binding pocket near the activation function-2 (AF-2) helix (i...
January 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29310223/portable-vibration-assisted-filtration-device-for-on-site-isolation-of-blood-cells-or-pathogenic-bacteria-from-whole-human-blood
#8
Yong Tae Kim, Kyun Joo Park, Seyl Kim, Soon Ae Kim, Seok Jae Lee, Do Hyun Kim, Tae Jae Lee, Kyoung G Lee
Isolation of specific cells from whole blood is important to monitor disease prognosis and diagnosis. In this study, a vibration-assisted filtration (VF) device has been developed for isolation and recovery of specific cells such as leukocytes and pathogenic bacteria from human whole blood. The VF device is composed of three layers which was fabricated using injection molding with cyclic olefin copolymer (COC) pellets consisting of: a top layer with coin-type vibration motor (Ф = 10mm), a middle plate with a 1μm or 3μm-pore filter membrane to separate of Staphylococcus aureus (S...
March 1, 2018: Talanta
https://www.readbyqxmd.com/read/29306399/clinical-characterization-of-unknown-cryptogenic-status-epilepticus-suspected-as-encephalitis-a-multicenter-cohort-study
#9
Jung-Won Shin, Yong Seo Koo, Young-Soo Kim, Dong Wook Kim, Kwang Ki Kim, Seo-Young Lee, Hyun Kyung Kim, Hye-Jin Moon, Jung-Ah Lim, Jung-Ick Byun, Jun-Sang Sunwoo, Jangsup Moon, Soon-Tae Lee, Keun-Hwa Jung, Kyung-Il Park, Kon Chu, Jae Moon Kim, Yong-Won Cho, Ki-Young Jung, Sang Kun Lee
Autoimmune and unknown/cryptogenic encephalitis have been increasingly noted in the inflammatory etiology of new-onset status epilepticus (SE). We aimed to investigate clinical characteristics and the potential role of immunotherapy in encephalitis-related adult SE through our multicenter prospective SE registry. Among the 274 patients with SE, 35 (12.8%) patients demonstrated an inflammatory etiology and 19 out of 35 (54.3%) patients demonstrated unknown/cryptogenic cause. Patients with autoimmune and unknown/cryptogenic encephalitis shared similar clinical features...
February 15, 2018: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29302896/comparison-of-the-accuracy-of-noninvasive-hemoglobin-monitoring-for-preoperative-evaluation-between-adult-and-pediatric-patients-a-retrospective-study
#10
Yong-Hee Park, Seho Lim, Hyun Kang, Hwa-Yong Shin, Chong Wha Baek, Young Cheol Woo
We measured noninvasive hemoglobin (SpHb) levels during the pre-anesthesia visit in patients planning elective surgery. Differences between SpHb and laboratory-measured hemoglobin (Hblab) were compared between adult and pediatric patients. In the pre-anesthesia visiting office, we routinely monitor noninvasive Hb levels with oxygen saturation and heart rate using Masimo Radical-7® Pulse CO-Oximetry (Masimo Corp., Irvine, CA, USA). We attached the R1 20 (body weight, 10-50 kg) or R1 25 (body weight > 30 kg) probe on the index finger...
January 4, 2018: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/29302377/clinical-outcomes-of-endoscopic-hemostasis-for-bleeding-in-patients-with-unresectable-advanced-gastric-cancer
#11
In Ji Song, Hyun Ju Kim, Ji Ae Lee, Jun Chul Park, Sung Kwan Shin, Sang Kil Lee, Yong Chan Lee, Hyunsoo Chung
Purpose: Bleeding is one of the most serious complications of advanced gastric cancer (AGC) and is associated with a poor prognosis. This study aimed to evaluate the clinical outcomes of endoscopic hemostasis for bleeding in patients with unresectable AGC. Materials and Methods: This study included 106 patients with bleeding associated with gastric cancer who had undergone endoscopic hemostasis between January 2010 and December 2013. Clinical characteristics, treatment outcomes, including rates of successful endoscopic hemostasis and rebleeding, risk factors for rebleeding, and overall survival (OS) were investigated...
December 2017: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/29302256/heterogeneous-nuclear-ribonucleoprotein-a2b1-exerts-a-regulatory-role-in-lipopolysaccharide-stimulated-38b9-b-cell-activation
#12
Jisang Park, Chung-Hyeon Choe, Ju Kim, Jing Shian Yang, Jin Hyun Kim, Hyonseok Jang, Yong-Suk Jang
Major histocompatibility complex (MHC) class II molecules, which are recognized for their primary function of presenting an antigen to the T cell receptor, are involved in various signaling pathways in B cell activation. We identified heterogeneous nuclear ribonucleoprotein (hnRNP) A2B1 as an MHC class II molecule-associated protein involved in MHC class II-mediated signal transduction in lipopolysaccharide (LPS)-stimulated 38B9 B cells. Although the function of hnRNP A2B1 in the nucleus is primarily known, the level of hnRNP A2B1 in the cytoplasm was increased in LPS-stimulated 38B9 cells, while it was not detected in the cytoplasm of non-treated 38B9 cells...
December 2017: Immune Network
https://www.readbyqxmd.com/read/29302253/polyvinylidene-fluoride-alters-inflammatory-responses-by-activation-induced-cell-death-in-macrophages
#13
Hyun Gyung Kim, Sang Hoon Kim, Taek-Seung Kim, Tae Won Park, Ran Won, Hee-Deung Park, Soo An Choi, Yong Woo Jung
Carbon nanotubes (CNTs) are nanomaterials that have been employed in generating diverse materials. We previously reported that CNTs induce cell death in macrophages, possibly via asbestosis. Therefore, we generated CNT-attached polyvinylidene fluoride (PVDF), which is an established polymer in membrane technology, and then examined whether CNT-attached PVDF is immunologically safe for medical purposes compared to CNT alone. To test this, we treated RAW 264.7 murine macrophages (RAW cells) with CNT-attached PVDF and analyzed the production of nitric oxide (NO), a potent proinflammatory mediator, in these cells...
December 2017: Immune Network
https://www.readbyqxmd.com/read/29299900/guidelines-for-the-antibiotic-use-in-adults-with-acute-upper-respiratory-tract-infections
#14
REVIEW
Young Kyung Yoon, Chan Soon Park, Jae Wook Kim, Kyurin Hwang, Sei Young Lee, Tae Hoon Kim, Do Yang Park, Hyun Jun Kim, Dong Young Kim, Hyun Jong Lee, Hyun Young Shin, Yong Kyu You, Dong Ah Park, Shin Woo Kim
These guidelines were developed as part of the 2016 Policy Research Servicing Project by the Korea Centers for Disease Control and Prevention. A multidisciplinary approach was taken to formulate this guideline to provide practical information about the diagnosis and treatment of adults with acute upper respiratory tract infection, with the ultimate aim to promote the appropriate use of antibiotics. The formulation of this guideline was based on a systematic literature review and analysis of the latest research findings to facilitate evidence-based practice, and focused on key questions to help clinicians obtain solutions to clinical questions that may arise during the care of a patient...
December 2017: Infection & Chemotherapy
https://www.readbyqxmd.com/read/29295863/chicken-nanog-self-associates-via-a-novel-folding-upon-binding-mechanism
#15
Hee Jung Choi, Iktae Kim, Hong Jo Lee, Young Hyun Park, Jeong-Yong Suh, Jae Yong Han
NANOG plays a pivotal role in pluripotency acquisition and lineage specification in higher vertebrates, and its expression is restricted to primordial germ cells (PGCs) during early embryonic development. Mammalian NANOG self-associates via conserved tryptophan-repeat motifs in the C-terminal domain (CTD) to maintain pluripotency. Avian NANOG, however, lacks the conserved motifs, and the molecular mechanism underlying the biologic function is not clearly understood. Here, using spectroscopic and biochemical methods as well as cell-based assays, we report that chicken NANOG (cNANOG) oligomerizes through its CTD via a novel folding-upon-binding mechanism...
January 2, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29285042/treatment-patterns-and-outcomes-in-elderly-patients-with-metastatic-breast-cancer-a-multicenter-retrospective-study
#16
Jin Hyun Park, In Sil Choi, Ki Hwan Kim, Jin-Soo Kim, Kyung-Hun Lee, Tae-Yong Kim, Seock-Ah Im, Se Hyun Kim, Yu Jung Kim, Jee Hyun Kim
Purpose: Currently, there is little information regarding optimal treatment for metastatic breast cancer (MBC) in elderly patients. In this retrospective study, we examined a cohort of elderly patients with MBC receiving a range of treatments, in terms of demographic and clinicopathologic characteristics, treatment patterns, and outcomes. Methods: Patients aged 65 years and older, and diagnosed with MBC between 2003 and 2015, were identified from the databases of three academic hospitals in South Korea...
December 2017: Journal of Breast Cancer
https://www.readbyqxmd.com/read/29285039/cyclophosphamide-methotrexate-and-5-fluorouracil-as-palliative-treatment-for-heavily-pretreated-patients-with-metastatic-breast-cancer-a-multicenter-retrospective-analysis
#17
Jin Hyun Park, Seock-Ah Im, Ja Min Byun, Ki Hwan Kim, Jin-Soo Kim, In Sil Choi, Hee-Jun Kim, Kyung-Hun Lee, Tae-Yong Kim, Sae-Won Han, Do Youn Oh, Tae-You Kim
Purpose: This study aimed to evaluate the efficacy and safety of cyclophosphamide, methotrexate, and 5-fluorouracil (CMF) chemotherapy beyond standard treatment for anthracycline- and taxane-pretreated metastatic breast cancer (MBC). Methods: We consecutively enrolled 158 MBC patients who underwent CMF chemotherapy in a palliative setting at two academic hospitals in Korea between 2002 and 2016. Results: The median age of the 158 enrolled patients was 51 years (range, 30-77 years)...
December 2017: Journal of Breast Cancer
https://www.readbyqxmd.com/read/29285036/selective-radiation-therapy-for-ductal-carcinoma-in-situ-following-breast-conserving-surgery-according-to-age-and-margin-width-korean-radiation-oncology-group-11-04-and-16-02-studies
#18
Kyubo Kim, Jin Hee Kim, Yong Bae Kim, Chang-Ok Suh, Kyung Hwan Shin, Jin Ho Kim, Tae Hyun Kim, So-Youn Jung, Doo Ho Choi, Won Park, Seung Do Ahn, Su Ssan Kim, Ji Woon Yea, Min Kyu Kang, Dong Won Kim, Yi-Jun Kim
Purpose: The optimal indications for omitting adjuvant radiation therapy (RT) after breast-conserving surgery are still controversial in ductal carcinoma in situ (DCIS) of the breast. The purpose of this study was to validate the role of postoperative RT in DCIS patients aged ≤50 years and with tumor margin widths of <1 cm, both of which have been proven to be high-risk features for recurrence in cohorts not receiving RT. Methods: Using two multicenter retrospective studies on DCIS, a pooled analysis was performed among patients aged ≤50 years and with margin widths <1 cm...
December 2017: Journal of Breast Cancer
https://www.readbyqxmd.com/read/29284530/fimasartan-proteinuria-sustained-reduction-in-comparison-with-losartan-in-diabetic-chronic-kidney-disease-fantastic-study-protocol-for-randomized-controlled-trial
#19
Jang-Young Kim, Jung-Woo Son, Sungha Park, Tea-Hyun Yoo, Yong-Jin Kim, Dong-Ryeol Ryu, Ho Jun Chin
BACKGROUND: Fimasartan is the ninth angiotensin receptor blocker to be developed. However, it has not yet been evaluated for reno-protective effects in hypertensive diabetic chronic kidney disease (CKD). The target blood pressure (BP) for hypertensive diabetic CKD is also a controversial topic. This trial was designed to assess the reno-protective effects of fimasartan compared to those of losartan as a primary outcome. This study also compares the two drugs with regard to cardiovascular and renal outcomes in accordance with target systolic BP (SBP) (as secondary outcomes)...
December 29, 2017: Trials
https://www.readbyqxmd.com/read/29284214/detection-of-hepatitis-e-virus-genotypes-3-and-4-in-pig-farms-in-korea
#20
Yong-Hyun Kim, Byung-Joo Park, Hee-Seop Ahn, Sang-Hoon Han, Hyeon-Jeong Go, Dong-Hwi Kim, Joong-Bok Lee, Seung-Yong Park, Chang-Seon Song, Sang-Won Lee, In-Soo Choi
The zoonotic transmission of hepatitis E virus (HEV) is mostly mediated by HEV-3 and HEV-4, and domestic pigs are an important reservoir for these genotypes. A survey of 14 pig farms in Korea revealed HEV RNA in 30 of 148 (20.3%) fecal samples. HEV-3a and HEV-4c subtypes were identified from five (36%) and two (14%) pig farms, respectively. Phylogenetic analysis indicated that the isolated HEV strains were closely related with previously reported zoonotic strains in Korea. This genetic analysis can partially explain the possible source of the zoonotic transmission of HEV to humans in Korea...
December 28, 2017: Journal of Veterinary Science
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