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https://www.readbyqxmd.com/read/28795049/comparison-of-clinical-outcomes-between-in-vitro-fertilization-ivf-and-intracytoplasmic-sperm-injection-icsi-in-ivf-icsi-split-insemination-cycles
#1
Sun Hee Lee, Jae Hyun Lee, Yong-Seog Park, Kwang Moon Yang, Chun Kyu Lim
OBJECTIVE: This study aimed to compare the clinical outcomes between in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) in sibling oocytes. Additionally, we evaluated whether the implementation of split insemination contributed to an increase in the number of ICSI procedures. METHODS: A total of 571 cycles in 555 couples undergoing split insemination cycles were included in this study. Among them, 512 cycles (89.7%) were a couple's first IVF cycle...
June 2017: Clinical and Experimental Reproductive Medicine
https://www.readbyqxmd.com/read/28794629/design-of-theranostic-nanomedicine-ii-synthesis-and-physicochemical-properties-of-a-biocompatible-polyphosphazene-docetaxel-conjugate
#2
Yong Joo Jun, Jung Hyun Park, Prakash G Avaji, Kyung Su Park, Kyung Eun Lee, Hwa Jeong Lee, Youn Soo Sohn
To prepare an efficient theranostic polyphosphazene-docetaxel (DTX) conjugate, a new drug delivery system was designed by grafting a multifunctional lysine ethylester (LysOEt) as a spacer group along with methoxy poly(ethylene glycol) (MPEG) to the polyphosphazene backbone ([NP]n), and then DTX was conjugated to the carrier polymer using acid-cleavable cis-aconitic acid (AA) as a linker. The resultant polyphosphazene-DTX conjugate, formulated as [NP(MPEG550)3(Lys-OEt)(AA)(DTX)]n and named "Polytaxel", exhibited high water solubility and stability by forming stable polymeric micelles as shown in its transmission electron microscopy image and dynamic light scattering measurements...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28792745/sequential-combination-of-electro-fenton-and-electrochemical-chlorination-processes-for-treatment-of-anaerobically-digested-food-wastewater
#3
Yong-Uk Shin, Ha-Young Yoo, Seonghun Kim, Kyung-Mi Chung, Yong-Gyun Park, Kwang-Hyun Hwang, Seokwon Hong, Hyunwoong Park, Kangwoo Cho, Jaesang Lee
A two-stage sequential electro-Fenton (E-Fenton) oxidation followed by electrochemical chlorination (EC) was demonstrated to concomitantly treat high concentrations of organic carbon and ammonium nitrogen (NH4+-N) in real anaerobically-digested food wastewater (ADFW). The anodic Fenton process caused the rapid mineralization of phenol as a model substrate through the production of hydroxyl radical as the main oxidant. The electrochemical oxidation of NH4+ by a dimensionally stable anode (DSA) resulted in temporal concentration profiles of combined and free chlorine species that were analogous to those during the conventional breakpoint chlorination of NH4+...
August 9, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28791416/luteolin-induces-apoptotic-cell-death-via-antioxidant-activity-in-human-colon-cancer-cells
#4
Kyoung Ah Kang, Mei Jing Piao, Yea Seong Ryu, Yu Jae Hyun, Jeong Eon Park, Kristina Shilnikova, Ao Xuan Zhen, Hee Kyoung Kang, Young Sang Koh, Yong Joo Jeong, Jin Won Hyun
The present study determined whether luteolin induces HT-29 colon cancer cell death through an antioxidant effect such as the activation of antioxidant enzymes. Luteolin decreased cell viability in human colon cancer cells (HT-29), whereas it had no effect on normal colon cells (FHC). Luteolin induced apoptosis by activating the mitochondria-mediated caspase pathway in HT-29 cells. Luteolin caused loss of the mitochondrial membrane action potential, increased mitochondrial Ca2+ level, upregulated Bax, downregulated Bcl-2, induced the release of cytochrome c from mitochondria to the cytosol, and increased the levels of the active forms of caspase-9 and caspase-3...
August 2, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28781229/height-loss-was-associated-with-osteoporosis-in-korean-elderly-men-not-in-women-the-korea-national-health-and-nutrition-examination-survey-2008-2010
#5
Kyung-Sik Ahn, Chang Ho Kang, Sung Bum Cho, Kyung-Hwan Cho, Kyung-Do Han, Yong-Gyu Park, Yang-Hyun Kim
The degree of height loss varies among individuals, and excessive height loss can be a vertebral fracture or bone loss manifestation. The objective of this study was to examine the relationships between height loss and bone mineral density (BMD) and to assess the prevalence of osteoporosis according to the height loss quartiles. Data from the Korea National Health and Nutrition Examination Survey were analyzed. A total of 2799 participants more than 60 years old were included and subdivided into quartiles according to height loss (Q1-Q4)...
August 3, 2017: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/28776350/comparison-of-baseline-characteristics-between-community-based-and-hospital-based-suicidal-ideators-and-its-implications-for-tailoring-strategies-for-suicide-prevention-korean-cohort-for-the-model-predicting-a-suicide-and-suicide-related-behavior
#6
C Hyung Keun Park, Jae Won Lee, Sang Yeol Lee, Jungjoon Moon, Se Hoon Shim, Jong Woo Paik, Shin Gyeom Kim, Seong Jin Cho, Min Hyuk Kim, Seokho Kim, Jae Hyun Park, Sungeun You, Hong Jin Jeon, Yong Min Ahn
In this cross-sectional study, we aimed to identify distinguishing factors between populations with suicidal ideation recruited from hospitals and communities to make an efficient allocation of limited anti-suicidal resources according to group differences. We analyzed the baseline data from 120 individuals in a community-based cohort (CC) and 137 individuals in a hospital-based cohort (HC) with suicidal ideation obtained from the Korean Cohort for the Model Predicting a Suicide and Suicide-related Behavior (K-COMPASS) study...
September 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28775248/clinical-outcome-of-rituximab-and-intravenous-immunoglobulin-combination-therapy-in-kidney-transplant-recipients-with-chronic-active-antibody-mediated-rejection
#7
Tae Hyun Ban, Ji Hyun Yu, Byung Ha Chung, Bum Soon Choi, Cheol Whee Park, Yong-Soo Kim, Chul Woo Yang
BACKGROUND We previously reported that rituximab (RIT) and intravenous immunoglobulin (IVIg) combination therapy is effective in deterring the progression of chronic active antibody-mediated rejection (CAMR), but that report was based on the assessment of a small number of cases for a short period. MATERIAL AND METHODS Forty-three patients with CAMR were recruited during the study period after 2010. The patients were divided into high (n=17, 39.5%) and low proteinuria groups (n=26, 60.5%) based on spot urine protein-to-creatinine ratio of > or <3...
August 4, 2017: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/28774982/draft-genome-sequence-of-an-endophytic-fungus-gaeumannomyces-sp-strain-js-464-isolated-from-a-reed-plant-phragmites-communis
#8
Jung A Kim, Jongbum Jeon, Ki-Tae Kim, Gobong Choi, Sook-Young Park, Hyun-Jung Lee, Sang-Hee Shim, Yong-Hwan Lee, Soonok Kim
An endophytic fungus, Gaeumannomyces sp. strain JS-464, is capable of producing a number of secondary metabolites which showed significant nitric oxide reduction activity. The draft genome assembly has a size of 53,151,282 bp, with a G+C content of 53.11% consisting of 80 scaffolds with an N50 of 7.46 Mbp.
August 3, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28774159/comparison-of-changes-in-the-interstitial-cells-of-cajal-and-neuronal-nitric-oxide-synthase-positive-neuronal-cells-with-aging-between-the-ascending-and-descending-colon-of-f344-rats
#9
Sun Min Lee, Nayoung Kim, Hyun Jin Jo, Ji Hyun Park, Ryoung Hee Nam, Hye Seung Lee, Hyun Jin Kim, Moon Young Lee, Yong Sung Kim, Dong Ho Lee
Background/Aims: Neuronal degeneration and changes in interstitial cells of Cajal (ICCs) are important mechanisms of age-related constipation. This study aims to compare the distribution of ICCs and neuronal nitric oxide synthase (nNOS) with regard to age-related changes between the ascending colon (AC) and descending colon (DC) in 6-, 31-, and 74-week old and 2-year old male Fischer-344 rats. Methods: The amount of fecal pellet and the bead expulsion times were measured...
August 4, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28772972/frequency-stable-ionic-type-hybrid-gate-dielectrics-for-high-mobility-solution-processed-metal-oxide-thin-film-transistors
#10
Jae Sang Heo, Seungbeom Choi, Jeong-Wan Jo, Jingu Kang, Ho-Hyun Park, Yong-Hoon Kim, Sung Kyu Park
In this paper, we demonstrate high mobility solution-processed metal-oxide thin-film transistors (TFTs) by using a high-frequency-stable ionic-type hybrid gate dielectric (HGD). The HGD gate dielectric, a blend of sol-gel aluminum oxide (AlOx) and poly(4-vinylphenol) (PVP), exhibited high dielectric constant (ε~8.15) and high-frequency-stable characteristics (1 MHz). Using the ionic-type HGD as a gate dielectric layer, an minimal electron-double-layer (EDL) can be formed at the gate dielectric/InOx interface, enhancing the field-effect mobility of the TFTs...
June 3, 2017: Materials
https://www.readbyqxmd.com/read/28761295/the-clinical-profile-of-patients-with-psoriasis-in-korea-a-nationwide-cross-sectional-study-epi-psode
#11
Hae Jun Song, Chul Jong Park, Tae Yoon Kim, Yong Beom Choe, Seok-Jong Lee, Nack In Kim, Jae We Cho, Jie Hyun Jeon, Min Soo Jang, Jai Il Youn, Myung Hwa Kim, Joonsoo Park, Ki Ho Kim, Byung Soo Kim, Sang Woong Youn, Joo-Heung Lee, Min-Geol Lee, Sung Ku Ahn, Young Ho Won, Seok Kweon Yun, Bong Seok Shin, Seong Jun Seo, Ji Yeoun Lee, Kwang Joong Kim, Young Suck Ro, Youngdoe Kim, Dae Young Yu, Jee-Ho Choi
BACKGROUND: Psoriasis is an immune-mediated, chronic inflammatory disease affecting multiple aspects of patients' lives. Its epidemiology varies regionally; however, nationwide epidemiologic data on psoriasis depicting profile of Korean patients has not been available to date. OBJECTIVE: To understand nationwide epidemiologic characteristics and clinical features of adult patients with psoriasis visited university hospitals in Korea. METHODS: This multicenter, non-interventional, cross-sectional study recruited 1,278 adult patients with psoriasis across 25 centers in Korea in 2013...
August 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28758167/joint-data-harmonization-and-group-cardinality-constrained-classification
#12
Yong Zhang, Sang Hyun Park, Kilian M Pohl
To boost the power of classifiers, studies often increase the size of existing samples through the addition of independently collected data sets. Doing so requires harmonizing the data for demographic and acquisition differences based on a control cohort before performing disease specific classification. The initial harmonization often mitigates group differences negatively impacting classification accuracy. To preserve cohort separation, we propose the first model unifying linear regression for data harmonization with a logistic regression for disease classification...
October 2016: Medical Image Computing and Computer-assisted Intervention: MICCAI ..
https://www.readbyqxmd.com/read/28758088/lipoma-compressing-the-sciatic-nerve-in-a-patient-with-suspicious-central-post-stroke-pain
#13
Ju Yong Kim, Hyun Jung Koo, Geun-Young Park, Yongmin Choi
Lipomas are mostly located in the subcutaneous tissues and rarely cause symptoms. Occasionally, peripheral nerve compression by lipomas is reported. We describe a case of a 59-year-old man with a left-middle cerebral artery infarction who was newly diagnosed as right basal ganglia and thalamic intracranial hemorrhage. He had neuropathic pain in the left arm and leg that was suspected to be central post-stroke pain. The administration of pain medication brought only temporary symptom relief. Nerve conduction and electromyography studies revealed left L5 radiculopathy and he showed a positive 'sign of the buttock' in the left hip...
June 2017: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/28757890/in-vivo-and-in-vitro-hepatoprotective-effects-of-geranium-koreanum-methanolic-extract-via-downregulation-of-mapk-caspase-3-pathway
#14
Md Rashedunnabi Akanda, In-Shik Kim, Dongchoon Ahn, Hyun-Jin Tae, Weishun Tian, Hyeon-Hwa Nam, Byung-Kil Choo, Byung-Yong Park
Geranium koreanum (GK) is an indigenous Chinese herbal medicine widely used for the treatment of various inflammation and liver disorders. However, the exact mechanism of action of GK remains unknown. This study aimed to investigate the protective effect and related molecular mechanism of GK on NaAsO2-induced cytotoxicity in HepG2 cells and liver damage in mice. The cytoprotective role of GK was assessed on HepG2 cells using MTT assay. Oxidative stress and lactate dehydrogenase levels were measured with ROS and LDH assay...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28757360/fusion-of-regionally-specified-hpsc-derived-organoids-models-human-brain-development-and-interneuron-migration
#15
Yangfei Xiang, Yoshiaki Tanaka, Benjamin Patterson, Young-Jin Kang, Gubbi Govindaiah, Naomi Roselaar, Bilal Cakir, Kun-Yong Kim, Adam P Lombroso, Sung-Min Hwang, Mei Zhong, Edouard G Stanley, Andrew G Elefanty, Janice R Naegele, Sang-Hun Lee, Sherman M Weissman, In-Hyun Park
Organoid techniques provide unique platforms to model brain development and neurological disorders. Whereas several methods for recapitulating corticogenesis have been described, a system modeling human medial ganglionic eminence (MGE) development, a critical ventral brain domain producing cortical interneurons and related lineages, has been lacking until recently. Here, we describe the generation of MGE and cortex-specific organoids from human pluripotent stem cells that recapitulate the development of MGE and cortex domains, respectively...
July 26, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/28754884/von-hippel-lindau-regulates-interleukin-32%C3%AE-stability-in-ovarian-cancer-cells
#16
Hyo Jeong Yong, Jeong Su Park, Ae Lee Jeong, Sora Han, Sunyi Lee, Hye In Ka, Buyanravjkh Sumiyasuren, Hyun Jeong Joo, Su Jeong So, Ji Young Park, Do-Young Yoon, Jong Seok Lim, Myeong-Seok Lee, Hee Gu Lee, Young Yang
Hypoxia-induced interleukin-32β (IL-32β) shifts the metabolic program to the enhanced glycolytic pathway. In the present study, the underlying mechanism by which hypoxia-induced IL-32β stability is regulated was investigated in ovarian cancer cells. IL-32β expression increased under hypoxic conditions in ovarian cancer cells as it did in breast cancer cells. The amount of IL-32β was regulated by post-translational control rather than by transcriptional activation. Under normoxic conditions, IL-32β was continuously eliminated through ubiquitin-dependent degradation by the von-Hippel Lindau (VHL) E3 ligase complex...
July 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/28753222/acute-hemorrhagic-rectal-ulcer-ahru-syndrome-comparison-with-non-ahru-lower-gastrointestinal-bleeding
#17
Joo Hyuk Jung, Jong Wook Kim, Hyun Woo Lee, Min Yong Park, Woo Hyun Paik, Won Ki Bae, Nam-Hoon Kim, Kyung-Ah Kim, June Sung Lee
AIM: Acute hemorrhagic rectal ulcer (AHRU) syndrome can cause massive, life-threatening rectal bleeding. Sigmoidoscopic hemostasis with enema can often be performed to effectively control rectal bleeding. METHODS: The medical records of AHRU patients were retrospectively reviewed. The baseline clinical characteristics were compared with those of non-AHRU lower gastrointestinal bleeding patients to identify predictive factors for AHRU. RESULTS: Among the 118 patients who underwent emergent endoscopy due to acute massive hematochezia from 2013 to 2015, 25 (21...
July 28, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28750069/does-repeated-pleural-culture-increase-the-diagnostic-yield-of-mycobacterium-tuberculosis-from-tuberculous-pleural-effusion-in-hiv-negative-individuals
#18
Yousang Ko, Jinkyung Song, Suh-Young Lee, Jin-Wook Moon, Eun-Kyung Mo, Ji Young Park, Joo-Hee Kim, Sunghoon Park, Yong Il Hwang, Seung Hun Jang, Byung Woo Jhun, Yun Su Sim, Tae Rim Shin, Dong-Gyu Kim, Ji Young Hong, Chang Youl Lee, Myung Goo Lee, Cheol-Hong Kim, In Gyu Hyun, Yong Bum Park
BACKGROUND: Despite recent advances in methods for culturing Mycobacterium tuberculosis (MTB), the diagnostic yield of tuberculous pleural effusion (TBPE) remains unsatisfactory. However, unlike repeated sputum cultures of pulmonary tuberculosis, little is known about the role of repeated pleural cultures. We examined whether repeated pleural cultures are associated with increased MTB yield from TBPE. METHODS: A multicenter, retrospective cohort study was performed from January 2012 to December 2015 in South Korea...
2017: PloS One
https://www.readbyqxmd.com/read/28749677/nature-inspired-construction-of-two-dimensionally-self-assembled-peptide-on-pristine-graphene
#19
Young Hyun No, Nam Hyeong Kim, Bramaramba Gnapareddy, Bumjoon Choi, Yong-Tae Kim, Sreekantha Reddy Dugasani, One-Sun Lee, Kook-Han Kim, Young-Seon Ko, Seungwoo Lee, Sang Woo Lee, Sung Ha Park, Kilho Eom, Yong Ho Kim
Peptide assemblies have received significant attention because of their important role in biology and applications in bionanotechnology. Despite recent efforts to elucidate the principles of peptide self-assembly for developing novel functional devices, peptide self-assembly on two-dimensional nanomaterials has remained challenging. Here, we report nature-inspired two-dimensional peptide self-assembly on pristine graphene via optimization of peptide-peptide and peptide-graphene interactions. Two-dimensional peptide self-assembly was designed based on statistical analyses of >10(4) protein structures existing in nature and atomistic simulation-based structure predictions...
July 31, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28748683/erratum-to-the-kmds-nation-study-korean-movement-disorders-society-multicenter-assessment-of-non-motor-symptoms-and-quality-of-life-in-parkinson-s-disease-nation-study-group
#20
Do Young Kwon, Seong Beom Koh, Jae Hyeok Lee, Hee Kyung Park, Han Joon Kim, Hae Won Shin, Jinyoung Youn, Kun Woo Park, Sun Ah Choi, Sang Jin Kim, Seong Min Choi, Ji Yun Park, Beom S Jeon, Ji Young Kim, Sun Ju Chung, Chong Sik Lee, Jeong Ho Park, Tae Beom Ahn, Won Chan Kim, Hyun Sook Kim, Sang Myung Cheon, Hee Tae Kim, Jee Young Lee, Ji Sun Kim, Eun Joo Kim, Jong Min Kim, Kwang Soo Lee, Joong Seok Kim, Min Jeong Kim, Jong Sam Baik, Ki Jong Park, Hee Jin Kim, Mee Young Park, Ji Hoon Kang, Sook Kun Song, Yong Duk Kim, Ji Young Yun, Ho Won Lee, Hyung Geun Oh, Jinwhan Cho, In Uk Song, Young H Sohn, Phil Hyu Lee, Jae Woo Kim
This corrects the article on p. 393 in vol. 12, PMID: 27819413.
July 2017: Journal of Clinical Neurology
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