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https://www.readbyqxmd.com/read/29149625/the-effects-of-pre-and-post-slaughter-spray-application-with-organic-acids-on-microbial-population-reductions-on-beef-carcasses
#1
Hoa Van Ba, Hyun-Woo Seo, Seong Pil-Nam, Yoon-Seok Kim, Beom Young Park, Sung-Sil Moon, Se-Ju Kang, Yong-Min Choi, Jin-Hyoung Kim
As an attempt to control bacterial cross-contamination of beef carcasses, in the present investigation acetic acid and lactic acid (3% v/v) were used for bacterial decontamination. For the decontamination, cows were sprayed with each above acid at two different stages; (i) on live animal's hides, (ii) on carcass surfaces immediately after slaughter. Microbiological samples were taken on different hide areas of animals before spraying and on carcass surfaces at 24h after spraying. Meat quality traits were also analyzed on the sprayed animals...
November 6, 2017: Meat Science
https://www.readbyqxmd.com/read/29147097/characterization-of-paenibacillus-sp-mbt213-isolated-from-raw-milk-and-its-ability-to-convert-ginsenoside-rb1-into-ginsenoside-rd-from-panax-ginseng
#2
Gereltuya Renchinkhand, Soo Hyun Cho, Magsar Urgamal, Young W Park, Joong Hyeon Nam, Hyung Churl Bae, Gyu Yong Song, Myoung Soo Nam
This study was conducted to isolate and characterize Paenibacillus sp. MBT213 possessing β-glucosidase activity from raw milk, and examine the enzymatic capacity on the hydrolysis of a major ginsenoside (Rb1). Strain MBT213 was found to have a high hydrolytic ability on ginsenoside Rb1 by Esculin Iron Agar test. 16S rDNA analysis revealed that MBT213 was Paenibacillu sp. Crude enzyme of MBT213 strain exhibited high conversion capacity on ginsenoside Rb1 into ginsenoside Rd proven by TLC and HPLC analyses. The API ZYM kit confirmed that Paenibacillu sp...
2017: Korean Journal for Food Science of Animal Resources
https://www.readbyqxmd.com/read/29146644/a-national-cohort-study-evaluating-infant-and-fetal-mortality-caused-by-birth-defects-in-korea
#3
Hyun Sun Ko, Dong Joo Kim, Yoohyun Chung, Jeong Ha Wie, Sae Kyung Choi, In Yarg Park, Yong Gyu Park, Jong Chul Shin
OBJECTIVE: To analyse the prevalence of fetal and infant deaths due to birth defects in Korea and those trends according to maternal age. DESIGN: Retrospective national cohort study SETTING: Korean Vital Statistics database of the Korean Statistical Information Service, between 2009 and 2015. PARTICIPANTS: 2176 infant deaths and 4343 fetal deaths caused by birth defects, among 3 181 145 total live births and 43 385 fetal deaths during the study periods...
November 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/29145250/consort-independent-prognostic-value-of-asphericity-of-pretherapeutic-f-18-fdg-uptake-by-primary-tumors-in-patients-with-breast-cancer
#4
Ji-Hoon Jung, Seung Hyun Son, Do-Hoon Kim, Jeeyeon Lee, Shin Young Jeong, Sang-Woo Lee, Ho Yong Park, Jaetae Lee, Byeong-Cheol Ahn
BACKGROUND: The aim of this study was to evaluate the prognostic implication of asphericity (ASP); spatial irregularity; of pretherapeutic F 2-deoxy-2-fluoro-D-glucose (F FDG) tumor uptake in patients with invasive ductal carcinoma (IDC) of the breast. METHODS: One hundred thirty-one female IDC patients (mean age = 48.1 ± 10.4 years), with pathological tumor size greater than 2 cm were retrospectively evaluated using F FDG positron emission tomography/computed tomography (PET/CT)...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29140280/trpv3-channel-in-keratinocytes-in-scars-with-post-burn-pruritus
#5
Chun Wook Park, Hyun Ji Kim, Yong Won Choi, Bo Young Chung, So-Youn Woo, Dong-Keun Song, Hye One Kim
Post-burn pruritus is a common and distressing sequela of burn scars. Empirical antipruritic treatments usually fail to have a satisfactory outcome because of their limited selectivity and possible side effects. Therefore, novel drug targets need to be identified. Here, we aimed to investigate the possible role of protease-activated receptor 2 (PAR2) and transient receptor potential vanniloid 3 (TRPV3), along with the relation of TRPV3 to thymic stromal lymphopoietin (TSLP). Specimens from normal (unscarred) or burn-scarred (with or without pruritus) tissue were obtained from burn patients for this study...
November 15, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29126291/the-dynamic-development-of-germ-cells-during-chicken-embryogenesis
#6
Seo Yeong Yang, Hong Jo Lee, Hyung Chul Lee, Young Sun Hwang, Young Hyun Park, Tamao Ono, Jae Yong Han
Appropriate regulation of cell proliferation during embryogenesis is crucial for the maintenance of germness. An in-depth understanding of germ cell developmental processes may yield valuable information on germ cell biology and applied sciences. However, direct evidences about germ cell proliferation and cell cycling during avian embryonic development has not been well-studied. Thus, we explored chicken germ cell dynamics during embryonic development via flow cytometry employing a germ cell-specific anti-cVASA antibody (the chicken VASA homolog is termed CVH) and propidium iodide staining...
November 4, 2017: Poultry Science
https://www.readbyqxmd.com/read/29123093/prevalence-and-detection-of-low-allele-fraction-variants-in-clinical-cancer-samples
#7
Hyun-Tae Shin, Yoon-La Choi, Jae Won Yun, Nayoung K D Kim, Sook-Young Kim, Hyo Jeong Jeon, Jae-Yong Nam, Chung Lee, Daeun Ryu, Sang Cheol Kim, Kyunghee Park, Eunjin Lee, Joon Seol Bae, Dae Soon Son, Je-Gun Joung, Jeeyun Lee, Seung Tae Kim, Myung-Ju Ahn, Se-Hoon Lee, Jin Seok Ahn, Woo Yong Lee, Bo Young Oh, Yeon Hee Park, Jeong Eon Lee, Kwang Hyuk Lee, Hee Cheol Kim, Kyoung-Mee Kim, Young-Hyuck Im, Keunchil Park, Peter J Park, Woong-Yang Park
Accurate detection of genomic alterations using high-throughput sequencing is an essential component of precision cancer medicine. We characterize the variant allele fractions (VAFs) of somatic single nucleotide variants and indels across 5095 clinical samples profiled using a custom panel, CancerSCAN. Our results demonstrate that a significant fraction of clinically actionable variants have low VAFs, often due to low tumor purity and treatment-induced mutations. The percentages of mutations under 5% VAF across hotspots in EGFR, KRAS, PIK3CA, and BRAF are 16%, 11%, 12%, and 10%, respectively, with 24% for EGFR T790M and 17% for PIK3CA E545...
November 9, 2017: Nature Communications
https://www.readbyqxmd.com/read/29121706/protective-effect-of-fucoidan-extract-from-ecklonia-cava-on-hydrogen-peroxide-induced-neurotoxicity
#8
Seon Kyeong Park, Jin Yong Kang, Jong Min Kim, Sang Hyun Park, Bong Seok Kwon, Gun-Hee Kim, Ho Jin Heo
We evaluated the antioxidant activity and neuronal cell-protective effect of fucoidan extract from Ecklonia cava (FEC) on hydrogen peroxide (H2O2)-induced cytotoxicity in PC-12 and MC-IXC cells to assess its protective effect against oxidative stress. Antioxidant activities were examined using the ABTS radical scavenging activity and malondialdehyde (MDA)-inhibitory effect, and the results showed that FEC had significant antioxidant activity. Intracellular ROS content and neuronal cell viability were investigated using DCF-DA assay and MTT reduction assay...
November 9, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29120086/how-effective-is-plasmonic-enhancement-of-colloidal-quantum-dots-for-color-conversion-light-emitting-devices
#9
Hyun Chul Park, Isnaeni, Suhyun Gong, Yong-Hoon Cho
Enhancing the fluorescence intensity of colloidal quantum dots (QDs) in case of color-conversion type QD light-emitting devices (LEDs) is very significant due to the large loss of QDs and their quantum yields during fabrication processes, such as patterning and spin-coating, and can therefore improve cost-effectiveness. Understanding the enhancement process is crucial for the design of metallic nanostructure substrates for enhancing the fluorescence of colloidal QDs. In this work, improved color conversion of colloidal green and red QDs coupled with aluminum (Al) and silver (Ag) nanodisk (ND) arrays designed by in-depth systematic finite-difference time domain simulations of excitation, spontaneous emission, and quantum efficiency enhancement is reported...
November 9, 2017: Small
https://www.readbyqxmd.com/read/29119480/rheumatoid-factor-false-positivity-in-patients-with-anca-associated-vasculitis-not-having-medical-conditions-producing-rheumatoid-factor
#10
Jae-Seung Moon, Diane Da-Hyun Lee, Yong-Beom Park, Sang-Won Lee
We investigated the rate of rheumatoid factor (RF) false positivity at diagnosis and its influence on clinical and prognostic features and rheumatoid arthritis (RA) development during the follow-up in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) patients without RA or other medical conditions triggering RF false positivity. We reviewed the medical records of 128 AAV patients. We divided patients with AAV and each variant into two groups according to RF positivity and compared variables between the two groups...
November 8, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29111746/voltage-drop-in-a-ferroelectric-single-layer-capacitor-by-retarded-domain-nucleation
#11
Yu Jin Kim, Hyeon Woo Park, Seung Dam Hyun, Han Joon Kim, Keum Do Kim, Young Hwan Lee, Taehwan Moon, Yong Bin Lee, Min Hyuk Park, Cheol Seong Hwang
Ferroelectric (FE) capacitor is a critical electric component in microelectronic devices. Among many of its intriguing properties, the recent finding of voltage drop (V-drop) across the FE capacitor while the positive charges flow in is especially eye-catching. This finding was claimed to be direct evidence that the FE capacitor is in negative capacitance (NC) state, which must be useful for (infinitely) high capacitance and ultralow voltage operation of field-effect transistors. Nonetheless, the NC state corresponds to the maximum energy state of the FE material, so it has been widely accepted in the community that the material alleviates that state by forming ferroelectric domains...
November 8, 2017: Nano Letters
https://www.readbyqxmd.com/read/29109064/surgical-outcomes-after-segmental-limited-surgery-for-adjacent-segment-disease-the-consequences-of-makeshif
#12
Dal-Sung Ryu, Jeong-Yoon Park, Sung-Uk Kuh, Dong-Kyu Chin, Keun-Su Kim, Yong-Eun Cho, Kyung-Hyun Kim
No abstract text is available yet for this article.
November 3, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29101906/characteristics-of-completed-suicide-in-different-blood-alcohol-concentrations-in-korea
#13
Jae Won Lee, C Hyung Keun Park, Eun Young Kim, Se Hyun Kim, Seong Ho Yoo, Yong Min Ahn
AIMS: This study aimed to determine the role of acute alcohol use among suicide decedents based on their blood alcohol concentrations (BAC), and identify sociodemographic and clinical characteristics associated with the differences in BAC. METHODS: Data were collected from nationwide autopsies conducted between May 2015 and November 2015 in South Korea. A total of 683 suicide decedents were classified into three groups according to the BAC at the time of autopsy: no alcohol (NA) group (BAC<0...
October 20, 2017: Forensic Science International
https://www.readbyqxmd.com/read/29100193/phase-ii-multicentre-randomised-trial-of-eribulin-plus-gemcitabine-versus-paclitaxel-plus-gemcitabine-as-first-line-chemotherapy-in-patients-with-her2-negative-metastatic-breast-cancer
#14
Yeon Hee Park, Seock-Ah Im, Sung-Bae Kim, Joo Hyuk Sohn, Keun Seok Lee, Yee Soo Chae, Ki Hyeong Lee, Jee Hyun Kim, Young-Hyuck Im, Ji-Yeon Kim, Tae-Yong Kim, Kyung-Hun Lee, Jin-Hee Ahn, Gun Min Kim, In Hae Park, Soo Jung Lee, Hye Sook Han, Se Hyun Kim, Kyung Hae Jung
BACKGROUND: Paclitaxel plus gemcitabine (PG) combination chemotherapy is a preferred chemotherapeutic regimen for patients with metastatic breast cancer (MBC). Eribulin mesylate is a halichondrin non-taxane inhibitor of microtubule dynamics. A recent pooled analysis with eribulin showed improved overall survival (OS) in various MBC patient subgroups pretreated with anthracycline and taxane. Furthermore, eribulin may have less neurotoxicity than paclitaxel. PATIENTS AND METHODS: This study was a prospective randomised phase II, open-label, two-arm, multicentre study comparing eribulin plus gemcitabine (EG) with PG chemotherapy as a first-line treatment for patients with human epidermal growth factor receptor 2-negative MBC...
November 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/29098930/biological-and-biochemical-characterization-of-m2b-cells-classical-bse-prion-is-conserved-in-transgenic-mice-overexpressing-bovine-prion-protein-gene
#15
Tae-Young Suh, In Soon Roh, Hyo-Jin Kim, Peter C Griffiths, Kyung Je Park, Hoo Chang Park, James Hope, Hae Eun Kang, Dae-Yong Kim, Hyun Joo Sohn
M2B cells with persistent classical bovine spongiform encephalopathy (C-BSE) have been established previously. In this study, we performed strain characterization of the M2B cell line in bovine PrP(C) overexpressing mice (Tg 1896). Mice intracranially inoculated with M2B cells and C-BSE survived for 451 ± 7 and 465 ± 31 d post inoculation, respectively. Although biochemical properties, including deglycosylation and conformational stability, differed between M2B cells and C-BSE, inoculation with M2B cell lysate and C-BSE resulted in comparable phenotypes...
November 3, 2017: Prion
https://www.readbyqxmd.com/read/29097919/preliminary-19-f-mrs-study-of-tumor-cell-proliferation-with-3-deoxy-3-fluorothymidine-and-its-metabolite-flt-mp
#16
In Ok Ko, Ki-Hye Jung, Mi Hyun Kim, Kyeung Jun Kang, Kyo Chul Lee, Kyeong Min Kim, Insup Noh, Yong Jin Lee, Sang Moo Lim, Jung Young Kim, Ji-Ae Park
The thymidine analogue 3'-deoxy-3'-[(18)F]fluorothymidine, or [(18)F]fluorothymidine ([(18)F]FLT), is used to measure tumor cell proliferation with positron emission tomography (PET) imaging technology in nuclear medicine. FLT is phosphorylated by thymidine kinase 1 (TK1) and then trapped inside cells; it is not incorporated into DNA. Imaging with (18)F-radiolabeled FLT is a noninvasive technique to visualize cellular proliferation in tumors. However, it is difficult to distinguish between [(18)F]FLT and its metabolites by PET imaging, and quantification has not been attempted using current imaging methods...
2017: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29096675/the-impact-of-sex-and-age-on-neurological-outcomes-in-out-of-hospital-cardiac-arrest-patients-with-targeted-temperature-management
#17
Sang Hoon Oh, Kyu Nam Park, Jeeyong Lim, Seung Pill Choi, Joo Suk Oh, In Soo Cho, Byung Kook Lee, Yong Hwan Kim, Young-Min Kim, Han Joon Kim, Chun Song Youn, Soo Hyun Kim
BACKGROUND: There are conflicting data regarding sex-based differences in the outcomes of out-of-hospital cardiac arrest (OHCA) patients, and whether the specific sex advantage is age-specific remains unclear. We assessed the impact of the interactions between sex and age on the neurological outcomes of OHCA patients receiving targeted temperature management (TTM). METHODS: Data collected from 2007 to 2012 for a multicenter, registry-based study of the Korean Hypothermia Network were analyzed...
November 2, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29094027/effect-of-intraperitoneal-co2-concentration-on-postoperative-pain-after-laparoscopic-cholecystectomy
#18
Ji Won Chung, Kyu Sik Kang, Sang Hyun Park, Chun Sook Kim, Jin Hun Chung, Sie Hyeon Yoo, Nan Seol Kim, Yong Han Seo, Ho Soon Jung, Hea Rim Chun, Hyung Youn Gong, Hae Il Jung, Sang Ho Bae, Su Yeon Park
Purpose: This study set out to identify the association between the intraperitoneal CO2 concentrations and postoperative pain by dividing the participants into a control group and 2 experimental groups receiving irrigation (1 L and 2 L), and directly measuring their intraperitoneal CO2 concentrations with a CO2 gas detector. Methods: A total of 101 patients, American Society of Anesthesiologists physical status classification I and II patients aged 18-65 years were enrolled in the study...
October 2017: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/29093771/current-awareness-and-use-of-the-strain-echocardiography-in-routine-clinical-practices-result-of-a-nationwide-survey-in-korea
#19
Ju-Hee Lee, Jae-Hyeong Park, Seung Woo Park, Woo-Shik Kim, Il Suk Sohn, Jung Yeon Chin, Jung Sun Cho, Ho-Joong Youn, Hae Ok Jung, Sun Hwa Lee, Seong-Hwan Kim, Wook-Jin Chung, Chi Young Shim, Jin-Won Jeong, Eui-Young Choi, Se-Joong Rim, Jang-Young Kim, Kye Hun Kim, Joon-Han Shin, Dae-Hee Kim, Ung Jeon, Jung Hyun Choi, Yong-Jin Kim, Seung Jae Joo, Ki-Hong Kim, Kyoung Im Cho, Goo-Yeong Cho
Background: Because conventional echocardiographic parameters have several limitations, strain echocardiography has often been introduced in clinical practice. However, there are also obstacles in using it in clinical practice. Therefore, we wanted to find the current status of awareness on using strain echocardiography in Korea. Methods: We conducted a nationwide survey to evaluate current use and awareness of strain echocardiography from the members of the Korean Society of Echocardiography...
September 2017: Journal of Cardiovascular Ultrasound
https://www.readbyqxmd.com/read/29090916/deinococcucins-a-d-aminoglycolipids-from-deinococcus-sp-a-gut-bacterium-of-the-carpenter-ant-camponotus-japonicus
#20
Bora Shin, So Hyun Park, Byung-Yong Kim, Shin-Il Jo, Sang Kook Lee, Jongheon Shin, Dong-Chan Oh
Four new aminoglycolipids, deinococcucins A-D (1-4), were discovered from a Deinococcus sp. strain isolated from the gut of queen carpenter ants, Camponotus japonicus. The structures of deinococcucins A-D were elucidated as a combination of N-acetyl glucosamine, 2,3-dihydroxypropanoic acid, and an alkyl amine with a C16 or C17 hydrocarbon chain primarily based on 1D and 2D NMR and mass spectroscopic data. The exact location of the olefinic double bond in deinococcucins C and D (3 and 4) was assigned based on the liquid chromatography-mass spectroscopy data obtained after olefin metathesis...
November 1, 2017: Journal of Natural Products
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