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https://www.readbyqxmd.com/read/29750981/comparison-of-endoscopic-submucosal-dissection-and-surgery-for-superficial-esophageal-squamous-cell-carcinoma-a-propensity-score-matched-analysis
#1
Yang Won Min, Hyuk Lee, Byeong Geun Song, Byung-Hoon Min, Hong Kwan Kim, Yong Soo Choi, Jun Haeng Lee, Na-Young Hwang, Keumhee C Carriere, Poong-Lyul Rhee, Jae J Kim, Jae Ill Zo, Young Mog Shim
BACKGROUND AND AIMS: Endoscopic submucosal dissection (ESD) has been widely accepted for treating superficial esophageal squamous cell carcinoma (SESCC). However, long-term outcomes of ESD and esophagectomy for SESCC have not been compared. We compared the clinical outcomes of ESD and esophagectomy in a matched cohort. METHODS: Patients who underwent ESD and esophagectomy for SESCC were included. We selected SESCCs without obvious submucosal invasion from the surgical database by reviewing endoscopic images...
May 8, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29629022/impact-of-a-geometric-correction-for-proximal-flow-constraint-on-the-assessment-of-mitral-regurgitation-severity-using-the-proximal-flow-convergence-method
#2
Jeong Yoon Jang, Joon-Won Kang, Dong Hyun Yang, Sahmin Lee, Byung Joo Sun, Dae-Hee Kim, Jong-Min Song, Duk-Hyun Kang, Jae-Kwan Song
Background: Overestimation of the severity of mitral regurgitation (MR) by the proximal isovelocity surface area (PISA) method has been reported. We sought to test whether angle correction (AC) of the constrained flow field is helpful to eliminate overestimation in patients with eccentric MR. Methods: In a total of 33 patients with MR due to prolapse or flail mitral valve, both echocardiography and cardiac magnetic resonance image (CMR) were performed to calculate regurgitant volume (RV)...
March 2018: Journal of Cardiovascular Ultrasound
https://www.readbyqxmd.com/read/29565186/scalp-metastasis-from-endometrial-carcinoma-a-case-report-and-literature-review
#3
Tserenchimed Khurelbaatar, Ki-Jin Ryu, Kyung-Jin Min, Sanghoon Lee, Jin Hwa Hong, Jae Yun Song, Jae Kwan Lee, Nak Woo Lee
No abstract text is available yet for this article.
March 22, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29544871/cryptogenic-stroke-and-high-risk-patent-foramen-ovale-the-defense-pfo-trial
#4
Pil Hyung Lee, Jae-Kwan Song, Jong S Kim, Ran Heo, Sahmin Lee, Dae-Hee Kim, Jong-Min Song, Duk-Hyun Kang, Sun U Kwon, Dong-Wha Kang, Dongwhane Lee, Hyuk Sung Kwon, Sung-Cheol Yun, Byung Joo Sun, Jae-Hyeong Park, Jae-Hwan Lee, Hye Seon Jeong, Hee-Jung Song, Jei Kim, Seung-Jung Park
BACKGROUND: Recent reports showing the favorable role of patent foramen ovale (PFO) closure in patients with cryptogenic stroke have raised the issue of selecting optimal candidates. OBJECTIVES: We evaluated whether the benefits of PFO closure can be determined based on the morphologic characteristics of the PFO, as evaluated by transesophageal echocardiography. METHODS: Patients with cryptogenic stroke and high-risk PFO were divided between a transcatheter PFO closure and a medication-only group...
February 28, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29540263/emergence-of-multidrug-resistant-clones-in-levofloxacin-nonsusceptible-streptococcus-pneumoniae-isolates-in-korea
#5
Jin Yang Baek, Cheol-In Kang, So Hyun Kim, Kwan Soo Ko, Doo Ryeon Chung, Kyong Ran Peck, Nam Yong Lee, Jae-Hoon Song
The use of fluoroquinolones to treat respiratory tract infections and pneumonia due to Streptococcus pneumoniae has affected the emergence of resistance to this class of drugs. Increasing pneumococcal resistance to levofloxacin has become a major public health concern. We investigated the prevalence and genetic characteristics of levofloxacin-nonsusceptible S. pneumoniae (LNSP) clinical isolates in Korea. A total of 43 LNSP isolates collected from a national surveillance study at 13 tertiary hospitals between 2008 and 2014 were analyzed for serotype and antimicrobial susceptibilities to 19 antimicrobial agents as well as the quinolone resistance-determining region mutation...
February 16, 2018: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29502364/time-dependent-reversal-of-significant-intrapulmonary-shunt-after-liver-transplantation
#6
Xin Jin, Byung Joo Sun, Jae-Kwan Song, Jae-Hyung Roh, Jeong Yoon Jang, Dae-Hee Kim, Young-Suk Lim, Jong-Min Song, Duk-Hyun Kang, Sung Gyu Lee
Background/Aims: Although the association between intrapulmonary shunt (IPS) and liver cirrhosis is clear, data of repeated contrast echocardiography (CE) before and after liver transplantation (LT) to evaluate factors associated with IPS are limited. Methods: Hand-agitated saline was used for CE and, by assessing left-chamber opacification, IPS was classified as grade 0 to 4. Grade 3/4 constituted significant IPS and hepatopulmonary syndrome (HPS) was defined as significant IPS with the arterial partial pressure of oxygen < 70 mmHg...
March 5, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29472703/suppression-of-the-erk-srf-axis-facilitates-somatic-cell-reprogramming
#7
Sejong Huh, Hwa-Ryung Song, Geuk-Rae Jeong, Hyejin Jang, Nan-Hee Seo, Ju-Hyun Lee, Ji-Yeun Yi, Byongsun Lee, Hyun Woo Choi, Jeong Tae Do, Jin-Su Kim, Soo-Hong Lee, Jae-Won Jung, Taekyu Lee, Jaekyung Shim, Myung-Kwan Han, Tae-Hee Lee
The molecular mechanism underlying the initiation of somatic cell reprogramming into induced pluripotent stem cells (iPSCs) has not been well described. Thus, we generated single-cell-derived clones by using a combination of drug-inducible vectors encoding transcription factors (Oct4, Sox2, Klf4 and Myc) and a single-cell expansion strategy. This system achieved a high reprogramming efficiency after metabolic and epigenetic remodeling. Functional analyses of the cloned cells revealed that extracellular signal-regulated kinase (ERK) signaling was downregulated at an early stage of reprogramming and that its inhibition was a driving force for iPSC formation...
February 23, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29460005/impact-of-pannus-formation-on-hemodynamic-dysfunction-of-prosthetic-aortic-valve-pannus-extent-and-its-relationship-to-prosthetic-valve-motion-and-degree-of-stenosis
#8
Hyun Jung Koo, Hojin Ha, Joon-Won Kang, Jeong A Kim, Jae-Kwan Song, Hwa Jung Kim, Tae-Hwan Lim, Dong Hyun Yang
BACKGROUND: Although pannus is an important cause of prosthetic valve dysfunction, the minimum pannus size that can induce hemodynamic dysfunction has not yet been determined. This study investigated the correlation between the limitation of motion (LOM) of the prosthetic valve and pannus extent and determined the pannus extent that could induce severe aortic stenosis. METHODS: This study included 49 patients who underwent mechanical aortic valve replacement (AVR) and showed pannus on cardiac computed tomography (CT)...
February 19, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29401560/budget-impact-of-the-accreditation-program-for-clinical-laboratories-on-colorectal-cancer-screening-via-fecal-immunochemical-testing-results-from-the-national-cancer-screening-program-in-korea
#9
Jae Kwan Jun, Na Young Sung, Seung Hoon Song, Seri Hong, Mi Ae Jang, Junghan Song, Jeong Ho Kim, Won Ki Min, You Kyoung Lee
BACKGROUND: False-positive fecal immunochemical test (FIT) results in the National Cancer Screening Program (NCSP) for colorectal cancer may lead to unnecessary procedures, such as colonoscopies, increasing the medical costs. We estimated reductions in the cost of National Health Insurance according to the accreditation status of screening facilities participating in the NCSP for colorectal cancer. METHODS: We used data collected between 2007 and 2010 from NCSP and the Korea Central Cancer Registry to identify patients with colorectal cancer...
May 2018: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/29396865/comparison-between-characteristics-of-severe-and-very-severe-aortic-stenosis
#10
Hidekazu Tanaka, Yong-Jin Kim, Seung-Ji Park, Seung Woo Park, Takeshi Hozumi, Chisato Izumi, Lieng His Ling, Cheuk-Man Yu, Shota Fukuda, Yutaka Otsuji, Jae-Kwan Song, Dae-Won Sohn
OBJECTIVES: Patients with very severe aortic stenosis (AS) have extremely poor clinical outcomes even if they are asymptomatic compared to those with severe AS, but the clinical and echocardiographic characteristics of patients with very severe AS remain unclear. METHODS: The Asian Valve Registry is a prospective, multicenter, multinational registry for the study and identification of the incidence, natural course, clinical outcomes, and prognostic factors for patients with significant AS at 9 centers in Asian countries...
April 2018: Echocardiography
https://www.readbyqxmd.com/read/29347957/high-parasite-burden-increases-the-surfacing-and-mortality-of-the-manila-clam-ruditapes-philippinarum-in-intertidal-sandy-mudflats-on-the-west-coast-of-korea-during-hot-summer
#11
Ki-Woong Nam, Hee-Do Jeung, Jae-Hee Song, Kwan-Ha Park, Kwang-Sik Choi, Kyung-Il Park
BACKGROUND: Over the past few decades, mass mortality events of Manila clams have been reported from several tidal flats on the west coast of Korea during hot summers. During such mortality events, once clams simultaneously surface, they fail to re-burrow, perishing within a week. The present study aimed to identify the possible causes of the mass mortality of this clam species by investigating the Perkinsus olseni parasite burden and immune parameters of surfaced clams (SC) and normal buried clams (NBCs) when sea water or sediment temperature in the study area varied from 25 °C to 34 °C from late July through mid-August 2015...
January 18, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29343988/does-breast-density-measured-through-population-based-screening-independently-increase-breast-cancer-risk-in-asian-females
#12
Boyoung Park, Hye Mi Cho, Eun Hye Lee, Seunghoon Song, Mina Suh, Kui Son Choi, Bong Joo Kang, Kyungran Ko, Ann Yi, Hae Kyoung Jung, Joo Hee Cha, Jae Kwan Jun
Purpose: The purpose of this study was to investigate the effects of breast density on breast cancer risk among women screened via a nationwide mammographic screening program. Patients and methods: We conducted a nested case-control study for a randomly selected population of 1,561 breast cancer patients and 6,002 matched controls from the National Cancer Screening Program. Breast density was measured and recorded by two independent radiologists using the Breast Imaging Reporting and Data System (BI-RADS)...
2018: Clinical Epidemiology
https://www.readbyqxmd.com/read/29248661/mitral-valve-adaptation-to-isolated-annular-dilation-insights-into-the-mechanism-of-atrial-functional-mitral-regurgitation
#13
Dae-Hee Kim, Ran Heo, Mark D Handschumacher, Sahmin Lee, Yun-Sil Choi, Kyu-Ri Kim, Yewon Shin, Hong-Kyung Park, Joyce Bischoff, Elena Aikawa, Jong-Min Song, Duk-Hyun Kang, Robert A Levine, Jae-Kwan Song
OBJECTIVES: This study hypothesized that compensatory mitral leaflet area (MLA) adaptation occurs in patients with persistent atrial fibrillation (AF) without left ventricular (LV) dysfunction but has limitations that augment mitral regurgitation (MR). The study also explored whether asymmetrical annular dilation is matched by relative leaflet enlargement. BACKGROUND: Functional MR occurs in patients with AF and isolated annular dilation, but the relationship of MLA adaptation with annular area (AA) is unknown...
December 8, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29245779/optimum-thickness-of-epsilon-negative-tri-metal-layer-electrodes-for-maximizing-oled-outcoupling-efficiency
#14
The Viet Hoang, Song Eun Lee, Jae-Gon Lee, Young Kwan Kim, Jeong-Hae Lee
A transparent electrode is an essential component that has a strong influence on the extraction of light from organic light-emitting diodes (OLEDs) due to its effect on both electrical and optical performance. In this work, we present theoretical studies, full wave simulations, and experimental results to evaluate the influence of the thickness of epsilon negative tri-metal layer (TML) electrodes on the performance of red phosphorescent OLEDs (PHOLEDs) via an optical microcavity effect. The results show that the external quantum efficiency of the optimized TML-based red PHOLED of 17...
December 11, 2017: Optics Express
https://www.readbyqxmd.com/read/29223427/late-outcome-of-percutaneous-mitral-commissurotomy-randomized-comparison-of-inoue-versus-double-balloon-technique
#15
RANDOMIZED CONTROLLED TRIAL
Sahmin Lee, Duk-Hyun Kang, Dae-Hee Kim, Jong-Min Song, Jae-Kwan Song, Seong-Wook Park, Seung-Jung Park
BACKGROUND: Late prognosis after successful percutaneous mitral commissurotomy (PMC) is unclear. We compared late results of PMC using Inoue versus double-balloon techniques up to 25 years in a randomized trial. METHODS: Between 1989 and 1995, 302 patients (77 men, 41 ± 11 years) with severe mitral stenosis were randomly assigned to undergo PMC using Inoue (n = 152; group I) or double-balloon technique (n = 150; group D). The end points were the composite events of death, mitral surgery, repeat PMC, or deterioration of New York Heart Association (NYHA) class ≥3...
December 2017: American Heart Journal
https://www.readbyqxmd.com/read/29171200/clinical-characteristics-of-korean-patients-with-bicuspid-aortic-valve-who-underwent-aortic-valve-surgery
#16
Byung Joo Sun, Xin Jin, Jae Kwan Song, Sahmin Lee, Ji Hye Lee, Jun Bean Park, Seung Pyo Lee, Dae Hee Kim, Sung Ji Park, Yong Jin Kim, Goo Yeong Cho, Jong Min Song, Duk Hyun Kang, Dae Won Sohn
BACKGROUND AND OBJECTIVES: Clinical data for Korean patients with bicuspid aortic valve (BAV) that underwent aortic valve (AV) surgery are currently limited. METHODS: Data for 1,160 consecutive adult BAV patients who underwent AV surgery from 2000 to 2014 in 4 tertiary referral centers were retrospectively analyzed. A standard case report form was used for clinical and echocardiographic parameters. RESULTS: Mean age at the time of AV surgery was 59±13 years...
January 2018: Korean Circulation Journal
https://www.readbyqxmd.com/read/29158019/impact-of-significant-mitral-regurgitation-on-assessing-the-severity-of-aortic-stenosis
#17
Pil Hyung Lee, Jung Ae Hong, Byung Joo Sun, Seungbong Han, Sangwoo Park, Jeong Yoon Jang, Dae-Hee Kim, Duk-Hyun Kang, Jae-Kwan Song, Jong-Min Song
BACKGROUND: Significant mitral regurgitation (MR) may reduce a pressure gradient of aortic stenosis (AS) by decreasing forward stroke volume. The study objective was to evaluate whether significant MR can cause inconsistency when assessing the severity of AS. METHODS: Among 5,355 patients diagnosed with AS from 2000 to 2015, 68 were retrospectively found to have concomitant significant (moderate or greater) MR and normal left ventricular ejection fractions in normal sinus rhythm (AS with MR)...
January 2018: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/29133568/activity-of-ceftolozane-tazobactam-against-carbapenem-resistant-non-carbapenemase-producing-pseudomonas-aeruginosa-and-associated-resistance-mechanisms
#18
Yu Mi Wi, Kerryl E Greenwood-Quaintance, Audrey N Schuetz, Kwan Soo Ko, Kyong Ran Peck, Jae-Hoon Song, Robin Patel
Although carbapenems are effective for treating serious multidrug-resistant Pseudomonas aeruginosa infections, carbapenem-resistant P. aeruginosa (CRPA) is now being reported worldwide. Ceftolozane-tazobactam (C/T) demonstrates activity against many multidrug-resistant isolates. We evaluated the activity of C/T and compared its activity to that of ceftazidime-avibactam (C/A) using a well-characterized collection of non-carbapenemase-producing CRPA isolates. Forty-two non-carbapenemase-producing CRPA isolates from a previous study (J...
January 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29103971/synthesis-and-biological-evaluation-of-thiazole-derivatives-as-gpr119-agonists
#19
Hyojin Kim, Suk Joon Cho, Minjin Yoo, Seung Kyu Kang, Kwang Rok Kim, Hwan Hee Lee, Jin Sook Song, Sang Dal Rhee, Won Hoon Jung, Jin Hee Ahn, Jae-Kyung Jung, Kwan-Young Jung
A series of 4-(phenoxymethyl)thiazole derivatives was synthesized and evaluated for their GPR119 agonistic effect. Several 4-(phenoxymethyl)thiazoles with pyrrolidine-2,5-dione moieties showed potent GPR119 agonistic activities. Among them, compound 27 and 32d showed good in vitro activity with an EC50 value of 49 nM and 18 nM, respectively with improved human and rat liver microsomal stability compare with MBX-2982. Compound 27 &32d did not exhibit significant CYP inhibition, hERG binding, and cytotoxicity...
December 1, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29066082/performance-of-a-simplified-dichotomous-phenotypic-classification-of-bicuspid-aortic-valve-to-predict-type-of-valvulopathy-and-combined-aortopathy
#20
Byung Joo Sun, Sahmin Lee, Jeong Yoon Jang, Osung Kwon, Jae Seok Bae, Ji Hye Lee, Dae-Hee Kim, Sung-Ho Jung, Jong-Min Song, Duk-Hyun Kang, Cheol Hyun Chung, Jae-Kwan Song
BACKGROUND: A simplified classification of bicuspid aortic valve (BAV) morphology using only the orientation of fused cusps was recently proposed. The aim of this study was to test whether it is useful for showing an association with the type of valvulopathy or aortopathy. METHODS: BAV phenotype was retrospectively classified in 681 patients (mean age, 59 ± 12 years; 424 men) who underwent aortic valve surgery. Each BAV was classified using both dichotomous (right and left coronary cusp fusion [CCF] vs mixed cusp fusion [MCF]) and conventional methods, and its association with the dominant valvulopathy (aortic stenosis [AS] vs regurgitation) and concomitant aortic surgery was analyzed...
December 2017: Journal of the American Society of Echocardiography
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