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https://www.readbyqxmd.com/read/28214000/comparison-of-results-of-tricuspid-valve-repair-versus-replacement-for-severe-functional-tricuspid-regurgitation
#1
Jeong Yoon Jang, Ran Heo, Sahmin Lee, Joon Bum Kim, Dae-Hee Kim, Sung-Cheol Yun, Jong-Min Song, Jae-Kwan Song, Jae-Won Lee, Duk-Hyun Kang
The optimal decision regarding whether to repair or replace the tricuspid valve (TV) remains controversial in patients with very severe functional tricuspid regurgitation (TR). We sought to compare clinical outcomes of TV repair versus replacement for very severe TR associated with severe TV tethering. We included 96 consecutive patients (20 men, 58 ± 11 years of age) who had both severe tethering of TV and very severe functional TR and consequently underwent TV surgery during left-sided valve surgery. TV repair was performed on 79 patients (repair group), whereas 17 patients underwent TV replacement (replacement group)...
January 30, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28179397/dipeptidyl-peptidase-4-induces-aortic-valve-calcification-by-inhibiting-insulin-like-growth-factor-1-signaling-in-valvular-interstitial-cells
#2
Bongkun Choi, Sahmin Lee, Sang-Min Kim, Eun-Jin Lee, Sun Ro Lee, Dae-Hee Kim, Jeong Yoon Jang, Sang-Wook Kang, Ki-Up Lee, Eun-Ju Chang, Jae-Kwan Song
Background -Calcification of the aortic valve leads to increased leaflet stiffness, and consequently to the development of calcific aortic valve disease (CAVD); however, the underlying molecular and cellular mechanisms of calcification remain unclear. Here, we identified that dipeptidyl peptidase-4 (DPP-4, also known as CD26) increases valvular calcification and promotes CAVD progression. Methods -We obtained the aortic valve tissues from humans and murine models (wild type and eNOS(-/-) mice), and cultured the valvular interstitial cells (VICs) and valvular endothelial cells (VECs) from the cusps...
February 8, 2017: Circulation
https://www.readbyqxmd.com/read/28147224/effectiveness-of-the-korean-national-cancer-screening-program-in-reducing-gastric-cancer-mortality
#3
Jae Kwan Jun, Kui Son Choi, Hoo-Yeon Lee, Mina Suh, Boyoung Park, Seung Hoon Song, Kyu Won Jung, Chan Wha Lee, Il Ju Choi, Eun-Cheol Park, Dukhyoung Lee
BACKGROUND & AIMS: It is not clear whether screening for gastric cancer by upper endoscopy or upper gastrointestinal (UGI) series examinations (looking at the upper and middle sections of the gastrointestinal tract by imaging techniques) reduces mortality. Nevertheless, the Korean National Cancer Screening Program for gastric cancer was launched in 1999 to screen individuals 40 years and older for gastric cancer using these techniques. We evaluated the effectiveness of these techniques in gastric cancer detection and compared their effects on mortality in the Korean population...
January 29, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28032486/current-situation-of-antimicrobial-resistance-and-genetic-differences-in-stenotrophomonas-maltophilia-complex-isolates-by-multilocus-variable-number-of-tandem-repeat-analysis
#4
Ji Young Rhee, Jae Hoon Song, Kwan Soo Ko
BACKGROUND: Stenotrophomonas maltophilia is one of several opportunistic pathogens of growing significance. Several studies on the molecular epidemiology of S. maltophilia have shown clinical isolates to be genetically diverse. MATERIALS AND METHODS: A total of 121 clinical isolates tentatively identified as S. malophilia from seven tertiary-care hospitals in Korea from 2007 to 2011 were included. Species and groups were identified using partial gyrB gene sequences and antimicrobial susceptibility testing was performed using a broth microdilution method...
December 2016: Infection & Chemotherapy
https://www.readbyqxmd.com/read/27929088/thioredoxin-interacting-protein-regulates-haematopoietic-stem-cell-ageing-and-rejuvenation-by-inhibiting-p38-kinase-activity
#5
Haiyoung Jung, Dong Oh Kim, Jae-Eun Byun, Won Sam Kim, Mi Jeong Kim, Hae Young Song, Young Kwan Kim, Du-Kyeong Kang, Young-Jun Park, Tae-Don Kim, Suk Ran Yoon, Hee Gu Lee, Eun-Ji Choi, Sang-Hyun Min, Inpyo Choi
Ageing is a natural process in living organisms throughout their lifetime, and most elderly people suffer from ageing-associated diseases. One suggested way to tackle such diseases is to rejuvenate stem cells, which also undergo ageing. Here we report that the thioredoxin-interacting protein (TXNIP)-p38 mitogen-activated protein kinase (p38) axis regulates the ageing of haematopoietic stem cells (HSCs), by causing a higher frequency of long-term HSCs, lineage skewing, a decrease in engraftment, an increase in reactive oxygen species and loss of Cdc42 polarity...
December 8, 2016: Nature Communications
https://www.readbyqxmd.com/read/27857022/trends-in-participation-rates-for-the-national-cancer-screening-program-in-korea-2002-2012
#6
Mina Suh, Seolhee Song, Ha Na Cho, Boyoung Park, Jae Kwan Jun, Eunji Choi, Yeol Kim, Kui Son Choi
Purpose: The National Cancer Screening Program (NCSP) in Korea supports cancer screening for stomach, liver, colorectal, breast, and cervical cancer. This study was conducted to assess trends in participation rates among Korean men and women invited to undergo screening via the NCSP as part of an effort to guide future implementation of the program in Korea. Materials and Methods: Data from the NCSP for 2002 to 2012 were used to calculate annual participation rates with 95% confidence intervals (CI) by gender, insurance status, and age group for stomach, liver, colorectal, breast, and cervical cancer screening...
November 11, 2016: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/27828718/5-7-dimethoxyflavone-attenuates-obesity-by-inhibiting-adipogenesis-in-3t3-l1-adipocytes-and-high-fat-diet-induced-obese-c57bl-6j-mice
#7
Youngwoo Song, Mi-Bo Kim, Changhee Kim, Jongwook Kim, Jae-Kwan Hwang
The antiobesity effect of 5,7-dimethoxyflavone (DMF) was evaluated in 3T3-L1 adipocytes and high-fat diet (HFD)-induced obese C57BL/6J mice. The accumulation of lipid droplets and triglycerides in adipocytes was dose dependently suppressed by DMF through inhibition of adipogenesis. DMF downregulated the adipogenic transcription factors (peroxisome proliferator-activated receptor [PPAR]γ, CCAAT/enhancer binding protein [C/EBP]α, and sterol regulatory element-binding protein-1c [SREBP-1c]) and lipid synthesis enzymes (fatty acid synthase [FAS], acetyl-CoA carboxylase [ACC], lipoprotein lipase [LPL], and HMG-CoA reductase [HMGR])...
December 2016: Journal of Medicinal Food
https://www.readbyqxmd.com/read/27826350/differential-diagnosis-of-a-left-atrial-mass-after-surgical-excision-of-myxoma-a-remnant-or-a-thrombus
#8
Hanbit Park, Seokjung Jo, Yun Kyung Cho, Jongkwan Kim, Sangcheol Cho, Ju Hyeon Kim, Yeong Jin Jeong, Jae-Kwan Song
Echocardiographic diagnosis of atrial myxoma may not always be straightforward, and the distinction between myxoma and thrombi is not easy, especially when we observe a mass after successful surgery. Our report describes a 72-year-old woman who presented with right upper limb hemiparesis and was subsequently diagnosed as having transient ischemic attack due to a left atrial myxoma. One month after successful surgical resection of the tumor, the patient developed left-sided weakness. Echocardiography revealed a left atrial mass attached to the interatrial septum...
November 2016: Korean Circulation Journal
https://www.readbyqxmd.com/read/27826345/long-term-results-of-early-surgery-versus-conventional-treatment-for-infective-endocarditis-trial
#9
Duk-Hyun Kang, Sahmin Lee, Yong-Jin Kim, Sung-Han Kim, Dae-Hee Kim, Sung-Cheol Yun, Jong-Min Song, Cheol-Hyun Chung, Jae-Kwan Song, Jae-Won Lee
BACKGROUND AND OBJECTIVES: Compared with conventional treatment, early surgery significantly reduced the composite end point of all-cause death and embolic events during hospitalization, but long-term data in this area are lacking. This study sought to compare long-term outcomes of early surgery with a conventional treatment strategy in patients with infective endocarditis (IE) and large vegetations. SUBJECTS AND METHODS: The Early Surgery versus Conventional Treatment in Infective Endocarditis (EASE) trial randomly assigned patients with left-sided IE, severe valve disease and large vegetation to early surgery (37 patients) or conventional treatment groups (39 patients)...
November 2016: Korean Circulation Journal
https://www.readbyqxmd.com/read/27753844/ed-02-1-acute-aortic-syndrome
#10
Jae-Kwan Song
The successful clinical introduction of various non-invasive imaging modalities has contributed to the establishment of 'acute aortic syndrome', a relatively new clinical syndrome incorporating several disease entities with similar clinical features (at the time of clinical presentation). Aortic dissection (AD) with intimal flap and two aortic channels (true and false lumens) is the most important disease entity in acute aortic syndrome. Clinical characteristics of AD have been established, with standardized treatment strategies depending on the affected site of the aorta...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27729364/basal-left-ventricular-dilatation-and-reduced-contraction-in-patients-with-mitral-valve-prolapse-can-be-secondary-to-annular-dilatation-preoperative-and-postoperative-speckle-tracking-echocardiographic-study-on-left-ventricle-and-mitral-valve-annulus-interaction
#11
Shota Fukuda, Jae-Kwan Song, Keitaro Mahara, Hiroshi Kuwaki, Jeong Yoon Jang, Masaaki Takeuchi, Byung Joo Sun, Yun Jeong Kim, Tetsu Miyamoto, Yasushi Oginosawa, Shinjo Sonoda, Masataka Eto, Yosuke Nishimura, Shuichiro Takanashi, Robert A Levine, Yutaka Otsuji
BACKGROUND: Prominent mitral valve (MV) annular dilatation with only modest left ventricular (LV) dilatation in patients with MV prolapse (MVP) suggests predominant dilatation in adjacent basal LV, which may augment regional wall tension and attenuate contraction by Laplace's law. We hypothesized that MV annular dilatation in patients with MVP is associated with the basal predominance of LV dilatation and attenuated contraction, which can be altered by surgical MV plasty with annulus reduction...
October 2016: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/27721950/impact-of-valvuloarterial-impedance-on-concentric-remodeling-in-aortic-stenosis-and-its-regression-after-valve-replacement
#12
Jeong Yoon Jang, Jeong-Sook Seo, Byung Joo Sun, Dae-Hee Kim, Jong-Min Song, Duk-Hyun Kang, Jae-Kwan Song
BACKGROUND: Left ventricle (LV) in patients with aortic stenosis (AS) faces a double hemodynamic load incorporating both valvular stenosis and reduced systemic arterial compliance (SAC). This study aimed to evaluate the impact of global LV afterload on LV hypertrophy (LVH) before and after aortic valve replacement (AVR). METHODS: The study cohort included 453 patients (247 males; mean age, 64 ± 11 years) who underwent AVR. Pre- and post-AVR echocardiographic examinations were retrospectively analyzed including an index of valvuloarterial impedance (ZVA) and LV mass index/LV end-diastolic volume index (LVMI/LVEDVI) as a parameter of LVH...
September 2016: Journal of Cardiovascular Ultrasound
https://www.readbyqxmd.com/read/27714942/management-of-atypical-squamous-cells-of-undetermined-significance-or-low-grade-squamous-intraepithelial-lesions-of-the-uterine-cervix-with-human-papilloma-virus-infection-among-young-women-aged-less-than-25-years
#13
MULTICENTER STUDY
Ki-Jin Ryu, Sanghoon Lee, Kyung-Jin Min, Jin Hwa Hong, Jae Yun Song, Jae Kwan Lee, Nak Woo Lee
Current ASCCP guidelines recommend repeat cytology 12 months after HPV-positive results in women aged 21-24 years with either atypical squamous cells of undetermined significance (ASCUS) or a low-grade squamous intraepithelial lesion (LSIL). The purpose of this study was to validate an algorithm in such women with ASCUS or LSIL. A multicenter cross-sectional study was carried out at three academic hospitals involving 40,847 Korean women who underwent cervical cancer screening with cytology and HPV testing with or without subsequent colposcopic biopsies between January 2007 and December 2013...
December 2016: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/27698717/tissue-injuries-after-single-port-and-multiport-laparoscopic-gynecologic-surgeries-a-prospective-multicenter-study
#14
Kyeong A So, Jae Kwan Lee, Jae Yun Song, Jae Won Kim, Nak Woo Lee, Kyung-Do Ki, Jong-Min Lee, Yong Jung Song, Yong Jin Na, Chun Hoe Ku, Jin Woo Shin, Chul Jung Kim, Un Suk Jung
The present study focused on the degree of tissue injury following single-port laparoscopic surgery (SPLS) and multiport laparoscopic surgery (MPLS) for the treatment of various benign gynecologic diseases. A total of 228 patients were prospectively enrolled at seven academic centers in South Korea between April 2011 and September 2012. Of these, 122 patients underwent SPLS and 106 patients underwent MPLS. The serum levels of C-reactive protein, creatine phosphokinase, lactic dehydrogenase and cancer antigen 125 were measured preoperatively and on postoperative day 4 by immunonephelometry...
October 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27666625/new-radiologic-classification-of-renal-angiomyolipomas
#15
Sohee Song, Byung Kwan Park, Jung Jae Park
PURPOSE: To introduce a new radiologic classification of renal angiomyolipoma (AML). MATERIALS AND METHODS: Between 1995 and 2014, CT or MR images in 98 patients with histologically proven 98 AMLs were reviewed independently by a radiologist and a resident. The lesions were classified as (a) 53 fat-rich AML (≤-10HU), (b) 22 fat-poor AML (>-10HU) with tumor-to-spleen ratio (TSR) <0.71 or signal intensity index (SII) >16.5%, and (c) 23 fat-invisible AML (>-10HU) with TSR ≥0...
October 2016: European Journal of Radiology
https://www.readbyqxmd.com/read/27643004/ed-02-1-acute-aortic-syndrome
#16
Jae-Kwan Song
The successful clinical introduction of various non-invasive imaging modalities has contributed to the establishment of 'acute aortic syndrome', a relatively new clinical syndrome incorporating several disease entities with similar clinical features (at the time of clinical presentation). Aortic dissection (AD) with intimal flap and two aortic channels (true and false lumens) is the most important disease entity in acute aortic syndrome. Clinical characteristics of AD have been established, with standardized treatment strategies depending on the affected site of the aorta...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27595231/infection-specific-phosphorylation-of-glutamyl-prolyl-trna-synthetase-induces-antiviral-immunity
#17
Eun-Young Lee, Hyun-Cheol Lee, Hyun-Kwan Kim, Song Yee Jang, Seong-Jun Park, Yong-Hoon Kim, Jong Hwan Kim, Jungwon Hwang, Jae-Hoon Kim, Tae-Hwan Kim, Abul Arif, Seon-Young Kim, Young-Ki Choi, Cheolju Lee, Chul-Ho Lee, Jae U Jung, Paul L Fox, Sunghoon Kim, Jong-Soo Lee, Myung Hee Kim
The mammalian cytoplasmic multi-tRNA synthetase complex (MSC) is a depot system that regulates non-translational cellular functions. Here we found that the MSC component glutamyl-prolyl-tRNA synthetase (EPRS) switched its function following viral infection and exhibited potent antiviral activity. Infection-specific phosphorylation of EPRS at Ser990 induced its dissociation from the MSC, after which it was guided to the antiviral signaling pathway, where it interacted with PCBP2, a negative regulator of mitochondrial antiviral signaling protein (MAVS) that is critical for antiviral immunity...
November 2016: Nature Immunology
https://www.readbyqxmd.com/read/27515269/antigenic-characterization-of-classical-swine-fever-virus-yc11wb-isolates-from-wild-boar
#18
Seong-In Lim, Yong Kwan Kim, Ji-Ae Lim, Song-Hee Han, Hee-Suk Hyun, Ki-Sun Kim, Bang-Hun Hyun, Jae-Jo Kim, In-Soo Cho, Jae-Young Song, Sung-Hyun Choi, Seung-Hoe Kim, Dong-Jun An
Classical swine fever (CSF), a highly contagious disease that affects domestic pigs and wild boar, has serious economic implications. The present study examined the virulence and transmission of strain YC11WB (isolated from a wild boar in 2011) in breeding wild boar. Virulence in domestic pigs was also examined. Based on the severe clinical signs and high mortality observed among breeding wild boar, the pathogenicity of strain YC11WB resembled that of typical acute CSF. Surprisingly, in contrast to strain SW03 (isolated from breeding pigs in 2003), strain YC11WB also showed both acute and strong virulence in breeding pigs...
August 10, 2016: Journal of Veterinary Science
https://www.readbyqxmd.com/read/27515126/differential-regulation-of-the-histone-chaperone-hira-during-muscle-cell-differentiation-by-a-phosphorylation-switch
#19
Jae-Hyun Yang, Tae-Yang Song, Chanhee Jo, Jinyoung Park, Han-Young Lee, Ilang Song, Suji Hong, Kwan Young Jung, Jaehoon Kim, Jeung-Whan Han, Hong-Duk Youn, Eun-Jung Cho
Replication-independent incorporation of variant histone H3.3 has a profound impact on chromatin function and numerous cellular processes, including the differentiation of muscle cells. The histone chaperone HIRA and H3.3 have essential roles in MyoD regulation during myoblast differentiation. However, the precise mechanism that determines the onset of H3.3 deposition in response to differentiation signals is unclear. Here we show that HIRA is phosphorylated by Akt kinase, an important signaling modulator in muscle cells...
2016: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/27461206/in-vivo-assessment-of-aortic-root-geometry-in-normal-controls-using-3d-analysis-of-computed-tomography
#20
Dong Hyun Yang, Dae-Hee Kim, Mark D Handschumacher, Robert A Levine, Joon Bum Kim, Byung Joo Sun, Jeong Yoon Jang, Namkug Kim, Seunghee Baek, Joon-Won Kang, Jong-Min Song, Duk-Hyun Kang, Tae-Hwan Lim, Jae-Kwan Song
AIMS: Understanding normal asymmetry in the aortic root could aid in the development of new surgical repair techniques or devices with improved haemodynamic performance. The purpose of this study was to assess geometric asymmetry and age-related changes in the normal aortic root using 3D computed tomography. METHODS AND RESULTS: The institutional review board approved this retrospective study of 130 normal subjects (mean age, 51.4 years; 58 men). Specialized 3D software measured individual cusp sinus volumes (CSVs), cusp surface areas (CSAs), and intercommissural distances (ICDs)...
July 26, 2016: European Heart Journal Cardiovascular Imaging
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