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https://www.readbyqxmd.com/read/29229954/recent-evolution-in-use-and-effectiveness-in-mainland-china-of-thoracic-endovascular-aortic-repair-of-type-b-aortic-dissection
#1
Jiang Xiong, Chen Chen, Zhongyin Wu, Duanduan Chen, Wei Guo
A meta-analysis was performed on 175 studies selected among those published in mainland China between 2008 and 2015 on thoracic endovascular aortic repair (TEVAR) for type B aortic dissection (AD). Most TEVAR were performed in Shanghai, Beijing, Hubei and Guangdong in patients with mean age of 53.9 years, and acute (70%) or chronic (30%) type B AD. Procedural success rate was 99.1 ± 0.8%. Major complication rate was 1.7 ± 2.3%, with paraplegia in 0.4 ± 0.0%. Overall in-hospital mortality rate was 1...
December 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29229868/sex-dependent-differences-in-inflammatory-responses-during-liver-regeneration-in-a-murine-model-of-acute-liver-injury
#2
Debora Bizzaro, Marika Crescenzi, Rosa Di Liddo, Diletta Arcidiacono, Andrea Cappon, Thomas Bertalot, Vincenzo Amodio, Alessia Tasso, Annalisa Stefani, Valentina Bertazzo, Giacomo Germani, Chiara Frasson, Giuseppe Basso, Pierpaolo Parnigotto, Malcolm Ronald Alison, Patrizia Burra, Maria Teresa Conconi, Francesco Paolo Russo
A sexual dimorphism in liver inflammation and repair was previously demonstrated. Its cellular dissection in the course of acute liver injury (ALI) was explored. BALB/c mice were treated with carbon tetrachloride (CCl4) by intraperitoneal injection and sacrificed after 3, 5 and 8 days. Histological and hepatic cell population analyses were performed. The correlation between androgen receptor (AR) expression and liver recruited inflammatory cells was investigated by treatment with the AR antagonist flutamide...
December 11, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29229611/opposing-actions-of-fibroblast-and-cardiomyocyte-smad3-signaling-in-the-infarcted-myocardium
#3
Ping Kong, Arti V Shinde, Ya Su, Ilaria Russo, Bijun Chen, Amit Saxena, Simon J Conway, Jonathan M Graff, Nikolaos G Frangogiannis
Background -Transforming Growth Factor (TGF)-βs regulate a wide range of cellular responses by activating Smad-dependent and Smad-independent cascades. In the infarcted heart, Smad3 signaling is activated in both cardiomyocytes and interstitial cells. We hypothesized that cell-specific actions of Smad3 regulate repair and remodeling in the infarcted myocardium. Methods -In order to dissect cell-specific Smad3 actions in myocardial infarction, we generated mice with Smad3 loss in activated fibroblasts, or in cardiomyocytes...
December 11, 2017: Circulation
https://www.readbyqxmd.com/read/29225602/sphingosine-1-phosphate-promotes-the-persistence-of-activated-cd4-t-cells-in-inflamed-sites
#4
Shafqat Ahrar Jaigirdar, Robert A Benson, Aziza Elmesmari, Mariola Stefania Kurowska-Stolarska, Iain B McInnes, Paul Garside, Megan K L MacLeod
Inflammation can be protective or pathogenic depending on context and timeframe. Acute inflammation, including the accumulation of CD4 T cells, accompanies protective immune responses to pathogens, but the presence of activated CD4 T cells at sites of inflammation is associated with chronic inflammatory disease. While significant progress has been made in understanding the migration of CD4 T cells into inflamed sites, the signals that lead to their persistence are poorly characterized. Using a murine ear model of acute inflammation and intravital two-photon imaging, we have dissected the signals that mediate CD4 T cell persistence...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29223561/microglia-and-astrocyte-activation-in-the-spinal-cord-of-lame-horses
#5
Constanza S Meneses, Heine Y Müller, Daniel E Herzberg, Benjamin Uberti, Marianne P Werner, Hedie A Bustamante
OBJECTIVE: To determine the microglial and astrocyte response to painful lameness in horses. STUDY DESIGN: Ionized calcium binding adaptor molecule 1 (Iba-1) and glial fibrillary acidic protein (GFAP) expression, cell density and morphology were determined through immunofluorescence within the dorsal horn of equine spinal cord. ANIMALS: A total of five adult horses with acute or chronic unilateral lameness, previously scheduled for euthanasia...
November 2, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/29221734/aortic-annulus-does-not-dilate-over-time-after-aortic-root-remodeling-with-or-without-annuloplasty
#6
Takashi Kunihara, Satoshi Arimura, Fumihiro Sata, Christian Giebels, Ulrich Schneider, Hans-Joachim Schäfers
OBJECTIVE: The lack of annular stabilization is the drawback of aortic root remodeling, and recently the addition of annuloplasty has been proposed. Limited data, however, exist on late annular size after remodeling. We studied annular size over time. METHODS: In 241 patients (53 ± 16 years) annular size was determined preoperatively (T0), before discharge (T1), and at least 2 years after remodeling (T2, 54 ± 27 months) with (n = 52) or without external suture annuloplasty...
December 5, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29221269/cluster-analysis-of-acute-ascending-aortic-dissection-provides-novel-insight-into-mechanisms-of-distal-progression
#7
Jennifer L Philip, Nilto C De Oliveira, Shahab A Akhter, Brooks L Rademacher, Christopher B Goodavish, Paul D DiMusto, Paul C Tang
Background: Whether primary tear size impacts extent of type A dissection is unclear. Using statistical groupings based on dissection morphology, we examined its relationship to primary tear area. Methods: We retrospectively reviewed 108 patients who underwent acute ascending dissection repair from 2000-2016. Dissection morphology was characterized using 3-dimensional (3D) reconstructions of computed tomography (CT) scan images. Two-step cluster analysis was performed to group the dissections by examining the true lumen area as a fraction of the total aortic area at various levels...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29218798/high-risk-clinical-features-for-acute-aortic-dissection-a-case-control-study
#8
Robert Ohle, Justin Um, Omar Anjum, Helena Bleeker, Lindy Luo, George Wells, Jeffrey J Perry
BACKGROUND: Acute aortic dissection (AAD) is a rare condition with a high mortality that is often missed. The objective of our study was to assess the diagnostic accuracy of clinical and laboratory findings for AAD, in confirmed cases of AAD and a low risk control group. METHODS: Historical matched case-control study: participants were adults >18 years old presenting to two tertiary care emergency departments (ED) or one regional cardiac referral center. CASES: new ED or in-hospital diagnosis of non-traumatic AAD confirmed by computed tomography or echocardiography...
December 8, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/29218111/the-diagnostic-value-of-microrna-4787-5p-and-microrna-4306-in-patients-with-acute-aortic-dissection
#9
Lei Wang, Shijie Zhang, Zhigao Xu, Jingjing Zhang, Li Li, Guoqiang Zhao
Acute aortic dissection (AAD) is a life-threatening cardiovascular disease with the high morbidity and mortality. Imaging modalities are the gold standard for the diagnosis of AAD; however, they are not always available in emergency department. Biomarker-assisted diagnosis is important for the early treatment of AAD. The aim of the present study was to identify potential microRNA (miRNA) biomarkers for AAD. Differentially expressed plasma miRNAs between AAD patients and age-matched healthy volunteers were analyzed by miRNA microarray...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/29217443/analysis-of-aortic-growth-rates-in-uncomplicated-type-b-dissection
#10
Maen Aboul Hosn, Paolo Goffredo, Jeffrey Zavala, William J Sharp, Neelima Katragunta, Timothy Kresowik, Rachael Nicholson, Luigi Pascarella
OBJECTIVES: Uncomplicated type B dissections have historically been treated medically with hemodynamic control. Early progression of the disease and late aneurysmal dilation have been considered as indications for intervention. The aim of this study is to analyze growth rate patterns of type B dissections based on Computed Tomography measurements over time. METHODS: We conducted a retrospective review of patients with acute type B dissection from 2008 to 2014 who had at least two follow up CT scans...
December 4, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29217246/acute-type-a-aortic-dissection-and-successful-surgical-repair-in-a-woman-at-21-weeks-gestational-pregnancy-with-maternal-and-fetal-survival-a-case-report
#11
Adam Barrus, Sam Afshar, Sara Sani, Troy G LaBounty, Cesar Padilla, Michaela K Farber, Andrew G Rudikoff, Antonio Hernandez Conte
No abstract text is available yet for this article.
September 14, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29217087/evolution-of-simplified-frozen-elephant-trunk-repair-for-acute-debakey-type-i-dissection-midterm-outcomes
#12
Eric E Roselli, Jay J Idrees, Faisal G Bakaeen, Michael Z Tong, Edward G Soltesz, Stephanie Mick, Douglas R Johnston, Mathew J Eagleton, Venu Menon, Lars G Svensson
BACKGROUND: A modified technique for frozen elephant trunk (FET) repair of acute DeBakey type I dissection has evolved. Procedural modifications are described and midterm outcomes evaluated. METHODS: From 2009 to 2016, 72 patients with DeBakey type I dissection underwent emergency simplified FET. Mean age was 59 ± 15 years. Presentation included malperfusion (n = 22, 31%), rupture (n = 12, 16%), and aortic insufficiency (n = 42, 58%). Concomitant procedures included valve replacement (n = 9), root replacement (n = 11; valve sparing n = 6), cusp repair (n = 11), and valve resuspension (n = 21)...
December 4, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29216976/ivus-guided-versus-oct-guided-coronary%C3%A2-stent-implantation-a-critical-appraisal
#13
REVIEW
Akiko Maehara, Mitsuaki Matsumura, Ziad A Ali, Gary S Mintz, Gregg W Stone
Procedural guidance with intravascular ultrasound (IVUS) imaging improves the clinical outcomes of patients undergoing percutaneous coronary intervention (PCI) by: 1) informing the necessity for lesion preparation; 2) directing appropriate stent sizing to maximize the final stent area and minimize geographic miss; 3) selecting the optimal stent length to cover residual disease adjacent to the lesion, thus minimizing geographic miss; 4) guiding optimal stent expansion; 5) identifying acute complications (edge dissection, stent malapposition, tissue protrusion); and 6) clarifying the mechanism of late stent failure (stent thrombosis, neointimal hyperplasia, stent underexpansion or fracture, or neoatherosclerosis)...
December 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29216679/the-role-of-extracorporeal-membrane-oxygenator-therapy-in-the-setting-of-type-a-aortic-dissection
#14
Ibrahim Sultan, Andreas Habertheuer, Tyler Wallen, Mary Siki, Wilson Szeto, Joseph E Bavaria, Matthew Williams, Prashanth Vallabhajosyula
BACKGROUND AND AIM: Patients presenting with type A aortic dissection (TAAD) present with a wide clinical spectrum ranging from hemodynamic stability to multiorgan malperfusion with cardiovascular collapse. Extracorporeal membrane oxygenator (ECMO) therapy is increasingly being utilized as salvage therapy in patients with acute cardiopulmonary failure and for post-cardiotomy shock. We sought to determine the utility of ECMO implementation post-TAAD repair. METHODS: The Pennsylvania Health Care Cost Containment Council (PHC4) database, maintained by an independently functioning state agency, was retrospectively reviewed from 2004 to 2014...
December 7, 2017: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/29209584/sudden-death-from-spontaneous-coronary-artery-dissection-due-to-polyarteritis-nodosa
#15
Cyrus M Munguti, Paul M Ndunda, Tabitha M Muutu
Spontaneous coronary artery dissection (SCAD) is an emerging and rare cause of acute coronary syndrome and sudden cardiac death. While it was previously reported among young females with fibromuscular dysplasia, new literature indicates that this condition could occur in older populations. Polyarteritis nodosa (PAN) causes systemic necrotizing vasculitis which typically affects small to medium-sized muscular arteries and could affect the coronary arteries. A few case reports of PAN causing acute coronary artery disease have been reported in the literature...
October 2, 2017: Curēus
https://www.readbyqxmd.com/read/29203969/cardiovascular-disease-in-ageing-an-overview-on-thoracic-aortic-aneurysm-as-an-emerging-inflammatory-disease
#16
REVIEW
Calogera Pisano, Carmela Rita Balistreri, Alessandro Ricasoli, Giovanni Ruvolo
Medial degeneration associated with thoracic aortic aneurysm and acute aortic dissection was originally described by Erdheim as a noninflammatory lesion related to the loss of smooth muscle cells and elastic fibre fragmentation in the media. Recent evidences propose the strong role of a chronic immune/inflammatory process in aneurysm evocation and progression. The coexistence of inflammatory cells with markers of apoptotic vascular cell death in the media of ascending aorta with aneurysms and type A dissections raises the possibility that activated T cells and macrophages may contribute to the elimination of smooth muscle cells and degradation of the matrix...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/29199177/inhibition-of-glycogen-phosphorylase-stimulates-ventromedial-hypothalamic-nucleus-amp-activated-protein-kinase-activity-and-neuronal-nitric-oxide-synthase-protein-expression-in-male-rats
#17
Hussain N Alhamami, Ayed Alshamrani, Karen P Briski
The glucose polymer glycogen is a vital fuel reserve in the brain. The mediobasal hypothalamic energy sensor AMP-activated protein kinase (AMPK) maintains glucostasis via neurotransmitter mechanisms that suppress [γ-aminobutyric acid; GABA] or stimulate [nitric oxide; steroidogenic factor-1 (SF1)] counter-regulatory outflow. This study investigated whether glycogen-derived fuel supply is a critical screened variable in ventromedial hypothalamic nucleus (VMN) monitoring of neuro-metabolic stability during glucostasis and/or insulin (I)-induced hypoglycemia...
December 2017: Physiological Reports
https://www.readbyqxmd.com/read/29197601/ectopic-expression-of-pcsk9-by-smooth-muscle-cells-contributes-to-aortic-dissection
#18
Yasunori Iida, Hiroki Tanaka, Hideto Sano, Yuko Suzuki, Hideyuki Shimizu, Tetsumei Urano
BACKGROUND: Acute aortic dissection (AAD) is a common disease among the elderly. Although several risk factors of AAD have been reported, the molecular mechanism underlying AAD development remains to be elucidated. Proprotein convertase subtilisin/kexin type 9 (PCSK9) increases LDL-cholesterol levels in blood by preventing its clearance. Therefore, PCSK9 inhibition is a promising therapeutic approach to treating cardiovascular diseases. The objective of this study was to elucidate the role of PCSK9 in the pathogenesis of AAD...
November 29, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29195573/complications-after-self-expanding-transcatheter-or-surgical-aortic-valve-replacement
#19
John V Conte, James Hermiller, Jon R Resar, G Michael Deeb, Thomas G Gleason, David H Adams, Jeffrey J Popma, Steven J Yakubov, Daniel Watson, Jia Guo, George L Zorn, Michael J Reardon
Procedural complications following transcatheter aortic valve replacement (TAVR) or surgical aortic valve replacement (SAVR) are usually reported as retrospective analyses. We report the first comparison of complications following SAVR or self-expanding TAVR from a prospectively randomized study of high-risk SAVR patients. Three hundred ninety-five TAVR and 402 SAVR patients were prospectively enrolled and randomized 1:1 to TAVR with a CoreValve bioprosthesis or a surgical bioprosthetic valve. The rates of major procedural and vascular complications occurring (periprocedurally (0-3 days) and early (4-30 days)) were compared for TAVR vs SAVR patients...
2017: Seminars in Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29189524/magnitude-of-soft-tissue-defect-as-a-predictor-of-free-flap-failures-does-size-matter
#20
Mark Shasti, Julio J Jauregui, Awais Malik, Gerard Slobogean, Walter Andrew Eglseder, Raymond A Pensy
OBJECTIVES: To examine the relationship between the magnitude of soft-tissue defect and the risk of free-flap and limb-salvage complications/failures. DESIGN: Retrospective cohort. SETTING: Level I Trauma Center. PATIENTS: One hundred twelve patients with free tissue transfers between January 2009 and June 2015. INTERVENTION: A standardized approach using a consistent team of 2 orthopaedic microvascular surgeons was used for each free-flap reconstruction...
December 2017: Journal of Orthopaedic Trauma
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