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https://www.readbyqxmd.com/read/28917981/intranasal-insulin-treatment-alleviates-methamphetamine-induced-anxiety-like-behavior-and-neuroinflammation
#1
Elmira Beirami, Shahrbanoo Oryan, Seyedeh Masoumeh Seyedhosseini Tamijani, Abolhassan Ahmadiani, Leila Dargahi
Insulin, as a peptide hormone, has recently gained attention for its pro-cognitive, anti-inflammatory and neuroprotective effects in the central nervous system (CNS). Most studies have indicated anxiogenic and neuroinflammatory effects of methamphetamine (MA) and other psychostimulants, even after periods of abstinence. The present study aimed to examine whether intranasal (IN) insulin treatment with high CNS bioavailability and minimal systemic side effects, can reverse the anxiety-like behavior and neuroinflammation induced by repeated MA administration...
September 14, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28917948/effects-of-methamphetamine-on-alloparental-behavior-in-male-and-female-prairie-voles
#2
Adam N Perry, Richard J Ortiz, Keziah R Hernandez, Bruce S Cushing
Psychostimulant abuse is associated with a variety of impairments in social functioning, including an increased frequency of depression and aggression and deficits in social cognition. Psychostimulants reduce social investigation in rats and mice; however, it is less clear how other forms of social behavior (e.g., prosocial behavior) are affected. Females are also generally more sensitive to the effects of psychostimulants on locomotion and stereotyped behavior, which suggests that females might also display greater disruption of prosocial behavior...
September 13, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28890714/gut-microbiota-analysis-in-rats-with-methamphetamine-induced-conditioned-place-preference
#3
Tingting Ning, Xiaokang Gong, Lingling Xie, Baomiao Ma
Methamphetamine abuse is a major public health crisis. Because accumulating evidence supports the hypothesis that the gut microbiota plays an important role in central nervous system (CNS) function, and research on the roles of the microbiome in CNS disorders holds conceivable promise for developing novel therapeutic avenues for treating CNS disorders, we sought to determine whether administration of methamphetamine leads to alterations in the intestinal microbiota. In this study, the gut microbiota profiles of rats with methamphetamine-induced conditioned place preference (CPP) were analyzed through 16S rRNA gene sequencing...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28886886/are-changes-in-excitability-in-the-hippocampus-of-adult-male-rats-induced-by-prenatal-methamphetamine-exposure-or-stress
#4
Klara Bernaskova, Simona Tomkova, Romana Slamberova
Prenatal stress and drug exposure induce permanent alterations of the brain. Even though different brain structures are involved, alterations almost always refer to the hippocampus. The aim of this study was to investigate the excitability of hippocampal slices in low-magnesium epilepsy model of prenatally methamphetamine (MA, 5mg/kg sc.) or saline (sc., stress model) exposed animals in adult male rats. The second aim was to investigate, if a low dose of MA (1ml/kgs.c.) administered in adulthood changes the hippocampal activity of these animals...
September 5, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28884876/intranasal-insulin-treatment-restores-cognitive-deficits-and-insulin-signaling-impairment-induced-by-repeated-methamphetamine-exposure
#5
Elmira Beirami, Shahrbanoo Oryan, Seyedeh Masoumeh Seyedhoseini Tamijani, Abolhassan Ahmadiani, Leila Dargahi
Long-term use of methamphetamine (MA) causes a broad range of cognitive deficits. Recently, it has been reported insulin signaling and mitochondrial biogenesis are involved in cognitive processes. This study aimed to examine whether MA induces cognitive deficits concomitant with insulin signaling impairment and mitochondrial dysfunctions and also intranasal (IN) insulin treatment can reverse cognitive deficits caused by MA. Rats were repeatedly treated with increasing doses of MA (1-10 mg/kg) twice a day for 10 days, and their cognitive functions were assessed using Y-maze, novel object recognition and passive avoidance tasks...
September 8, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28882561/locomotor-and-reinforcing-effects-of-pentedrone-pentylone-and-methylone-in-rats
#6
Mehrak Javadi-Paydar, Jacques D Nguyen, Sophia A Vandewater, Tobin J Dickerson, Michael A Taffe
The broad diversity of synthetic cathinone psychostimulant drugs that are available to users complicates research efforts to provide understanding of health risks. Second generation cathinones pentedrone and pentylone are distinguished from each other by the 3,4-methylenedioxy structural motif (which distinguishes methamphetamine from 3,4-methylenedioxymethamphetamine) and each incorporates the α-alkyl chain motif contained in the transporter-inhibitor cathinones (3,4-methylenedioxypyrovalerone (MDPV), α-pyrrolidinopentiophenone (α-PVP)) but not in the monoamine releasers (mephedrone, methylone)...
September 4, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28877870/circadian-variability-of-body-temperature-responses-to-methamphetamine
#7
Abolhassan Behrouzvaziri, Maria V Zaretskaia, Daniel Edward Rusyniak, Dmitry V Zaretsky, Yaroslav I Molkov
Vital parameters of living organisms exhibit circadian rhythmicity. Although rats are nocturnal animals, most of the studies involving rats are performed during the day. The objective of this study was to examine the circadian variability of the body temperature responses to methamphetamine (Meth). Body temperature was recorded in male Sprague-Dawley rats received Meth (1 or 5 mg/kg) or saline at 10am or 10pm. The baseline body temperature at night was 0.8ºC higher than during the day. Both during the day and at night 1 mg/kg of Meth induced monophasic hyperthermia...
September 6, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28870635/cannabidiol-inhibits-priming-induced-reinstatement-of-methamphetamine-in-rem-sleep-deprived-rats
#8
Saeideh Karimi-Haghighi, Abbas Haghparast
Methamphetamine (METH) is a widely abused and a severely addictive psychostimulant. Relapse is the main cause of concern when treating addiction. It could manifest after a long period of abstinence. Previous studies showed that there is a strong connection between sleep impairment and relapse. Also, it has been reported that cannabidiol might be a potential treatment for drug craving and relapse. In this study, we used conditioned place preference (CPP) to investigate whether Cannabidiol (CBD), a phytocannabinoid, can prevent METH-induced reinstatement in Rapid Eye Movement Sleep Deprived (RSD) rats...
September 1, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28870523/antagonism-of-mglu2-3-receptors-in-the-nucleus-accumbens-prevents-oxytocin-from-reducing-cued-methamphetamine-seeking-in-male-and-female-rats
#9
Aurelien Bernheim, Kah-Chung Leong, Carole Berini, Carmela M Reichel
Methamphetamine (meth) addiction is a prevalent health concern worldwide, yet remains without approved pharmacological treatments. Preclinical evidence suggests that oxytocin may decrease relapse, but the neuronal underpinnings driving this effect remain unknown. Here we investigate whether oxytocin's effect is dependent on presynaptic glutamatergic regulation in the nucleus accumbens core (NAcore) by blocking metabotropic glutamate receptors 2/3 (mGluR2/3). Male and female Sprague-Dawley rats self-administered meth or sucrose on an escalating fixed ratio, followed by extinction and cue-induced reinstatement sessions...
September 1, 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/28865391/discriminative-stimulus-and-locomotor-effects-of-para-substituted-and-benzofuran-analogs-of-amphetamine
#10
Sean B Dolan, Michael J Forster, Michael B Gatch
Novel psychoactive substances have maintained a prominent role in the global drug culture, despite increased regulation by governing bodies. Novel compounds continue to become available on the market, often in "Ecstasy" or "Molly" formulations in lieu of MDMA, at a much faster rate than they can be properly characterized. The current study aimed to investigate the discriminative stimulus and locomotor effects of three putatively entactogenic compounds that have become increasingly prevalent on the drug market: 5-(2-aminopropyl)-benzofuran (5-APB), 6-(2-aminopropryl)-2,3-dihydrobenzofuran (6-APDB), and 4-fluoroamphetamine (4-FA)...
August 24, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28863003/varenicline-and-gz-793a-differentially-decrease-methamphetamine-self-administration-under-a-multiple-schedule-of-reinforcement-in-rats
#11
Megan M Kangiser, Linda P Dwoskin, Guangrong Zheng, Peter A Crooks, Dustin J Stairs
Methamphetamine is a potent psychostimulant with high abuse rates. Currently, there is no Food and Drug Administration-approved pharmacotherapy for methamphetamine addiction. Ideally, a pharmacotherapy should selectively decrease methamphetamine self-administration without affecting responding for other reinforcers. One way to test this is with the use of a multiple schedule of reinforcement, in which drug and food are available in alternating components within a session. The present study evaluated GZ-793A, a vesicular monoamine transporter-2 inhibitor, and varenicline, a partial agonist at α4β2 and full agonist at α7 nicotinic acetylcholine receptors, for their ability to decrease methamphetamine and food self-administration using a multiple schedule of reinforcement...
August 31, 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/28861718/repeated-forced-swim-exacerbates-methamphetamine-induced-neurotoxicity-neuroprotective-effects-of-nanowired-delivery-of-5-ht3-receptor-antagonist-ondansetron
#12
José Vicente Lafuente, Aruna Sharma, Dafin F Muresanu, Asya Ozkizilcik, Z Ryan Tian, Ranjana Patnaik, Hari S Sharma
The possibility that stress associated with chronic forced swim (FS) may exacerbate methamphetamine (METH) neurotoxicity was examined in a rat model. Rats were subjected to FS in a pool (30 °C) for 15 min daily for 8 days. Control rats were kept at room temperature. METH was administered (9 mg/kg, s.c.) in both control and FS rats and allowed to survive 4 h after the drug injection. METH in FS rats exacerbated BBB breakdown to Evans blue albumin (EBA) by 150 to 220% and ([131])-Iodine by 250 to 380% as compared to naive rats after METH...
August 31, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28856500/methamphetamine-induced-brain-injury-and-alcohol-drinking
#13
Amanda L Blaker, Bryan K Yamamoto
A majority of methamphetamine (Meth) abusers also abuse alcohol but the neurochemical consequences of this co-abuse are unknown. Individually, alcohol and Meth cause inflammation and long-term alterations in dopamine and serotonin signaling within the brain. Experiments were conducted to identify if serial exposure to alcohol and Meth has neurochemical consequences that are greater than after either drug alone. Male Sprague Dawley rats voluntarily drank 10% ethanol (EtOH) every other day for 4 weeks and were then exposed to a binge injection regimen of Meth (10 mg/kg injected every 2 h, for a total of 4 injections)...
August 30, 2017: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://www.readbyqxmd.com/read/28842817/methamphetamine-induces-tet1-and-tet3-dependent-dna-hydroxymethylation-of-crh-and-avp-genes-in-the-rat-nucleus-accumbens
#14
Subramaniam Jayanthi, Betina Gonzalez, Michael T McCoy, Bruce Ladenheim, Veronica Bisagno, Jean Lud Cadet
Methamphetamine (METH) addiction is a biopsychosocial disorder that is accompanied by multiple relapses even after prolonged abstinence, suggesting the possibilities of long-lasting maladaptive epigenetic changes in the brain. Here, we show that METH administration produced time-dependent increases in the expression of corticotropin-releasing hormone (Crh/Crf), arginine vasopressin (Avp), and cocaine- and amphetamine-regulated transcript prepropeptide (Cartpt) mRNAs in the rat nucleus accumbens (NAc). Chromatin immunoprecipitation (ChIP) assays revealed that METH increased the abundance of phosphorylated CREB (pCREB) at the promoter of Cartpt but not at Avp or Crh DNA sequences...
August 25, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28842124/phencyclidine-induced-dysregulation-of-primary-cilia-in-the-rodent-brain
#15
Hiroki Shiwaku, Asami Umino, Masakazu Umino, Toru Nishikawa
Significant roles of the primary cilia in the central nervous system have been reported in neural generation and cognitive functions. However, little is known about the possible pathological changes in brain primary cilia in neuropsychiatric disorders. To obtain an insight into the relationship between cilial dysregulation and schizophrenia, we presently investigated the effects of psychotomimetics, phencyclidine, MK-801 (dizocilpine), and methamphetamine, on morphological and molecular indices in the rodent brain...
August 22, 2017: Brain Research
https://www.readbyqxmd.com/read/28831198/methamphetamine-abuse-impairs-motor-cortical-plasticity-and-function
#16
X Huang, Y-Y Chen, Y Shen, X Cao, A Li, Q Liu, Z Li, L-B Zhang, W Dai, T Tan, O Arias-Carrion, Y-X Xue, H Su, T-F Yuan
Exposure to addictive drugs triggers synaptic plasticity in reward-related brain regions, such as the midbrain, nucleus accumbens and the prefrontal cortex. Effects of chronic drug exposure on other brain areas have not been fully investigated. Here, we characterize synaptic plasticity in motor cortex after methamphetamine self-administration in rats. We show that this causes a loss of corticostriatal plasticity in rat brain slices and impaired motor learning in the rotarod task. These findings are paralleled by the observation of a lack of transcranial magnetic stimulation-induced potentiation or depression of motor evoked potentials in human patients with addiction, along with poor performance in rotary pursuit task...
September 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28827541/compulsive-methamphetamine-taking-in-the-presence-of-punishment-is-associated-with-increased-oxytocin-expression-in-the-nucleus-accumbens-of-rats
#17
Irina N Krasnova, Maria Carla Gerra, Donna Walther, Subramaniam Jayanthi, Bruce Ladenheim, Michael T McCoy, Christie Brannock, Jean Lud Cadet
Methamphetamine addiction is mimicked in rats that self-administer the drug. However, these self-administration (SA) models do not include adverse consequences that are necessary to reach a diagnosis of addiction in humans. Herein, we measured genome-wide transcriptional consequences of methamphetamine SA and footshocks in the rat brain. We trained rats to self-administer methamphetamine for 20 days. Thereafter, lever-presses for methamphetamine were punished by mild footshocks for 5 days. Response-contingent punishment significantly reduced methamphetamine taking in some rats (shock-sensitive, SS) but not in others (shock-resistant, SR)...
August 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28815279/evaluation-of-training-dose-in-male-sprague-dawley-rats-trained-to-discriminate-4-methylmethcathinone
#18
Michael D Berquist, Nathyn A Thompson, Lisa E Baker
RATIONALE: Although the synthetic cathinone 4-methylmethcathinone (4-MMC, mephedrone) has been a subject of intensive research investigation, the pharmacological mechanisms involved in its interoceptive stimulus effects have yet to be fully characterized. OBJECTIVE: The present study employed drug discrimination methods in rats to compare the interoceptive stimulus properties of two different training doses of 4-MMC to other substances with similar pharmacological actions...
August 16, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28814468/persistent-effects-of-acute-stress-on-fear-and-drug-seeking-in-a-novel-model-of-the-comorbidity-between-post-traumatic-stress-disorder-and-addiction
#19
Christie L Pizzimenti, Tom M Navis, K Matthew Lattal
Even following long periods of abstinence, individuals with anxiety disorders have high rates of relapse to drugs of abuse. Although many current models of relapse demonstrate effects of acute stress on drug-seeking, most of these studies examine stressful experiences that occur in close temporal and physical proximity to the reinstatement test. Here, we assess the effects of a stressful experience in one context on fear and drug-seeking in a different context. We adapt the stress-enhanced fear learning procedure to examine impacts on drug-seeking long after the stressful experience occurred...
September 2017: Learning & Memory
https://www.readbyqxmd.com/read/28754407/punishment-of-alcohol-reinforced-responding-in-alcohol-preferring-p-rats-reveals-a-bimodal-population-implications-for-models-of-compulsive-drug-seeking
#20
Nathan J Marchant, Erin J Campbell, Konstantin Kaganovsky
Individual variations in animal behaviour can be used to describe relationships between different constructs, as well as the underlying neurobiological mechanisms responsible for such variation. In humans, variation in the expression of certain traits contributes to the onset of psychopathologies, such as drug addiction. Addiction is characterised by persistent drug use despite negative consequences, but it occurs in only a sub-population of drug users. Compulsive drug use is modelled in laboratory animals by punishing a drug-reinforced operant response...
July 25, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
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