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https://www.readbyqxmd.com/read/28496953/estrogen-and-progesterone-replacement-therapy-prevent-methamphetamine-induced-synaptic-plasticity-impairment-in-ovariectomized-rats
#1
Hamed Ghazvini, Mohammad Shabani, Majid Asadi-Shekaari, Solmaz Khalifeh, Khadijeh Esmaeilpour, Mehdi Khodamoradi, Vahid Sheibani
BACKGROUND: Methamphetamine (METH) is one of the most popular psychostimulants which produce long lasting learning and memory impairment. Previous studies have indicated that estrogen and progesterone replacement therapy attenuate cognitive impairment against a wide array of neurodegenerative diseases. Present study was designed to figure out the effects of estrogen, progesterone alone or in combination, on early long-term potentiation (E-LTP) at the cornu ammonis (CA1) area of the hippocampus in METH-exposed ovariectomized (OVX) rat...
July 2016: Addiction & Health
https://www.readbyqxmd.com/read/28496496/environmental-enrichment-prevents-methamphetamine-induced-spatial-memory-deficits-and-obsessive-compulsive-behavior-in-rats
#2
Samira Hajheidari, Hossein Miladi-Gorji, Imanollah Bigdeli
Objective: This study was designed to examine the effect of environmental enrichment during methamphetamine (METH) dependency and withdrawal on methamphetamine-induced spatial learning and memory deficits and obsessive-compulsive behavior. Method: Adult male Wistar rats (200 ± 10 g) chronically received bi-daily doses of METH (2 mg/kg, sc, with 12 hours intervals) for 14 days. Rats reared in standard (SE) or enriched environment (EE) during the development of dependence on METH and withdrawal. Then, they were tested for spatial learning and memory (the water maze), and obsessive-compulsive behavior as grooming behavior in METH-withdrawn rats...
January 2017: Iranian Journal of Psychiatry
https://www.readbyqxmd.com/read/28477265/trans-generational-neurochemical-modulation-of-methamphetamine-in-the-adult-brain-of-the-wistar-rat
#3
Michaela Fujáková-Lipski, Daniel Kaping, Jana Šírová, Jiří Horáček, Tomáš Páleníček, Petr Zach, Jan Klaschka, Petr Kačer, Kamila Syslová, Monika Vrajová, Věra Bubenikova-Valešová, Christian Beste, Romana Šlamberová
Chronic methamphetamine (METH) abuse has been shown to elicit strong neurotoxic effects. Yet, with an increasing number of children born to METH abusing mothers maturing into adulthood, one important question is how far do the neurotoxic effects of METH alter various neurotransmitter systems in the adult METH-exposed offspring. The purpose of this study was to investigate long-term trans-generational neurochemical changes, following prenatal METH exposure, in the adult Wistar rat brain. METH or saline (SAL-control animals) was administered to pregnant dams throughout the entire gestation period (G0-G22)...
May 5, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28476409/differential-behavioral-effects-of-nicotine-in-adult-male-and-female-rats-with-a-history-of-prenatal-methamphetamine-exposure
#4
Boyd Rorabaugh, Sarah Seeley, Mary Evans, Christina Marengo, Manoranjan D'Souza
The goal of the current study was to assess the effects of prenatal methamphetamine (MA)/saline exposure on nicotine-induced stimulant and aversive effects in both male and female adult rats. The aversive effects of nicotine were assessed using the nicotine-induced conditioned taste aversion model (0.4mg/kg, base), while the stimulant effects of nicotine were measured by assessing changes in spontaneous locomotor activity after subcutaneous administration of different doses of nicotine (0, 0.1 & 0.4mg/kg, base)...
May 2, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28450692/the-ethyl-acetate-fraction-of-a-methanolic-extract-of-unripe-noni-morinda-citrifolia-linn-fruit-exhibits-a-biphasic-effect-on-the-dopaminergic-system-in-mice
#5
Vijayapandi Pandy, Megala Narasingam, Kamini Vijeepallam, Syam Mohan, Vasudevan Mani, Zahurin Mohamed
In earlier ex vivo studies, we reported the biphasic effect of a methanolic extract of unripe Morinda citrifolia fruit (MMC) on dopamine-induced contractility in isolated rat vas deferens preparations. The present in vivo study was designed and undertaken to further explore our earlier ex vivo findings. This study examined the effect of the ethyl acetate fraction of a methanolic extract of unripe Morinda citrifolia Linn. fruit (EA-MMC; 5-100 mg/kg, p.o.) on the dopaminergic system using mouse models of apomorphine-induced climbing time and climbing behavior, methamphetamine-induced stereotypy (sniffing, biting, gnawing, and licking) and haloperidol-induced catalepsy using the bar test...
April 26, 2017: Experimental Animals
https://www.readbyqxmd.com/read/28444326/preclinical-evidence-that-5-ht1b-receptor-agonists-show-promise-as-medications-for-psychostimulant-use-disorders
#6
Raul Garcia, Austin R Cotter, Kenneth Leslie, M Foster Olive, Janet L Neisewander
Background: 5-HT1B receptor (5-HT1BR) agonists enhance cocaine intake during daily self-administration sessions, but decrease cocaine intake when tested after prolonged abstinence. We examined if 5-HT1BR agonists produce similar abstinence-dependent effects on methamphetamine intake. Methods: Male rats were trained to self-administer methamphetamine (0.1 mg/kg, IV) on low (FR5 and VR5) and high (progressive ratio; PR) effort schedules of reinforcement until intake was stable...
April 22, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28437722/effective-active-vaccination-against-methamphetamine-in-female-rats
#7
J D Nguyen, P T Bremer, C S Hwang, S A Vandewater, K C Collins, K M Creehan, K D Janda, M A Taffe
BACKGROUND: Immunotherapies directed against methamphetamine (MA) abuse have shown success in rodent models, however only a limited number of studies have investigated active vaccination in female mice and none in female rats. It is critical to determine if potential immunotherapeutic strategies generalize across sex, particularly for drugs that may produce significant sex-differences on behavioral or physiological endpoints. METHODS: Female Wistar rats were initially vaccinated with keyhole-limpet hemocyanin (KLH) or an anti-methamphetamine-KLH conjugate (MH6-KLH) three times over five weeks and implanted with radiotelemetry devices to assess locomotor activity and body temperature responses to MA...
April 14, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28433511/design-synthesis-and-pharmacological-evaluation-of-4-azolyl-benzamide-derivatives-as-novel-gpr52-agonists
#8
Kazuyuki Tokumaru, Yoshiteru Ito, Izumi Nomura, Takashi Nakahata, Yuji Shimizu, Emi Kurimoto, Kazunobu Aoyama, Kazuyoshi Aso
G protein-coupled receptor 52 (GPR52) agonists are expected to improve the symptoms of psychiatric disorders. During exploration for a novel class of GPR52 agonists with good pharmacokinetic profiles, we synthesized 4-(3-(3-fluoro-5-(trifluoromethyl)benzyl)-5-methyl-1H-1,2,4-triazol-1-yl)-2-methylbenzamide (4u; half maximal effective concentration (EC50)=75nM, maximal response (Emax)=122%) starting from a high-throughput screening hit 3 (EC50=470nM, Emax=56%). The structural features of a reported GPR52 agonist were applied to 3, led to design 4-azolylbenzamides as novel GPR52 agonists...
April 1, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28421529/suppression-of-methamphetamine-self-administration-by-ketamine-pre-treatment-is-absent-in-the-methylazoxymethanol-mam-rat-model-of-schizophrenia
#9
Jana Ruda-Kucerova, Zuzana Babinska, Tibor Stark, Vincenzo Micale
Ketamine may prove to be a potential candidate in treating the widespread drug addiction/substance abuse epidemic among patients with schizophrenia. Clinical studies have shown ketamine to reduce cocaine and heroin cravings. However, the use of ketamine remains controversial as it may exacerbate the symptoms of schizophrenia. Therefore, the aim of this study is to characterize the effects of ketamine on drug addiction in schizophrenia using the methylazoxymethanol (MAM) acetate rat model on operant IV methamphetamine (METH) self-administration...
April 18, 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/28387990/cdh13-and-adipoq-gene-knockout-alter-instrumental-and-pavlovian-drug-conditioning
#10
C P King, L Militello, A Hart, C L St Pierre, E Leung, C L Versaggi, N Roberson, J Catlin, A A Palmer, J B Richards, P J Meyer
Genome-wide association studies in humans have suggested that variants of the cadherin-13 (CDH13) gene are associated with substance use disorder, subjective response to amphetamine, and attention deficit hyperactivity disorder. To examine the role of the Cdh13 and its peptide ligand adiponectin (AdipoQ) in addiction-related behaviors, we assessed Cdh13 knockout (KO) rats and AdipoQ KO mice using intravenous cocaine self-administration and conditioned place preference (CPP) paradigms. During intravenous cocaine self-administration, male Cdh13 heterozygous (+/-) and KO (-/-) rats showed increased cue-induced reinstatement compared with wild-type (WT) rats when presented with a cocaine-paired stimulus, whereas female Cdh13 rats showed no differences across genotype...
April 7, 2017: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/28386698/comparison-of-some-behavioral-effects-of-d-and-l-methamphetamine-in-adult-male-rats
#11
Justin N Siemian, Zhaoxia Xue, Bruce E Blough, Jun-Xu Li
RATIONALE: Both l- and d-methamphetamine (l- and d-MA) are more potent to release norpepinephrine (NE) than dopamine, and the selectivity is greater for l-MA than d-MA. Little is known of the in vivo pharmacology of l-MA. OBJECTIVE: This study compared the effects of l-MA and d-MA in assays of nociception, behavioral disruption, and impulsivity. METHODS: Antinociceptive effects of d- and l-MA were examined in two pain assays: the warm water tail withdrawal test for acute nociception and the von Frey test in complete Freund's adjuvant (CFA)-treated rats for chronic inflammatory pain...
April 6, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28359886/sex-differences-in-the-strategies-of-spatial-learning-in-prenatally-exposed-rats-treated-with-various-drugs-in-adulthood
#12
Eva Macúchová, Kateryna Nohejlová, Mária Ševčíková, Ivana Hrebíčková, Romana Šlamberová
In the present study we investigated the sex differences in the effect of adult long-term drug treatment on cognitive functions of Wistar rats, which were prenatally exposed to MA (5mg/kg) or saline. Cognitive functions were tested as an ability of spatial learning in the Morris Water Maze (MWM), which consisted of three types of tests: "Place Navigation Test"; "Probe Test", and "Memory Recall Test". Adult animals were injected daily, after completion of the last trial, either with saline or cocaine (COC; 5mg/kg), MDMA (3,4-methylenedioxy-methamphetamine; 5mg/kg), morphine (MOR; 5mg/kg), or delta-9-tetrahydrocannabinol (THC; 2mg/kg)...
June 1, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28351548/behavioral-sensitization-to-methamphetamine-induces-specific-interneuronal-mrna-pathology-across-the-prelimbic-and-orbitofrontal-cortices
#13
Travis A Wearne, Lindsay M Parker, Jane L Franklin, Ann K Goodchild, Jennifer L Cornish
Schizophrenia is associated with significant pathophysiological changes to interneurons within the prefrontal cortex (PFC), with mRNA and protein changes associated with the GABA network localized to specific interneuron subtypes. Methamphetamine is a commonly abused psychostimulant that can induce chronic psychosis and symptoms that are similar to schizophrenia, suggesting that chronic METH induced psychosis may be associated with similar brain pathology to schizophrenia in the PFC. The aim of this study, therefore, was to examine mRNA expression of interneuron markers across two regions of the PFC (prelimbic (PRL) and orbitofrontal cortices (OFC)) following METH sensitization, an animal model of METH psychosis...
March 27, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28348387/a-synthetic-small-molecule-isoxazole-9-protects-against-methamphetamine-relapse
#14
M H Galinato, J W Lockner, M J Fannon-Pavlich, J C Sobieraj, M C Staples, S S Somkuwar, A Ghofranian, S Chaing, A I Navarro, A Joea, B W Luikart, K D Janda, C Heyser, G F Koob, C D Mandyam
Adult neurogenesis in the dentate gyrus (DG) is strongly influenced by drug-taking behavior and may have a role in the etiology of drug-seeking behavior. However, mechanistic studies on the relationship of neurogenesis on drug seeking are limited. Outbred Wistar rats experienced extended access methamphetamine self-administration and individual differences in drug taking defined animals with higher preferred and lower preferred levels of drug intake. Forced abstinence from higher preferred levels of drug taking enhanced neurogenesis and neuronal activation of granule cell neurons (GCNs) in the DG and produced compulsive-like drug reinstatement...
March 28, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28341135/methamphetamine-induces-hepatotoxicity-via-inhibiting-cell-division-arresting-cell-cycle-and-activating-apoptosis-in%C3%A2-vivo-and-in%C3%A2-vitro-studies
#15
Qi Wang, Li-Wen Wei, Huan-Qin Xiao, Ye Xue, Si-Hao Du, Yun-Gang Liu, Xiao-Li Xie
Methamphetamine (METH) resulted in acute hepatic injury. However, the underlying mechanisms have not been fully clarified. In the present study, rats were treated with METH (15 mg/kg B.W.) for 8 injections (i.p.), and the levels of alanine transaminase, asparatate transaminase and ammonia in serum were significantly elevated over those in the control group, suggesting hepatic injury, which was evidenced by histopathological observation. Analysis of the liver tissues with microarray revealed differential expressions of a total of 332 genes in METH-treated rats...
March 21, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28339044/suppression-of-nuclear-factor-erythroid%C3%A2-2%C3%A2-related-factor-2%C3%A2-mediated-antioxidative-defense-in-the-lung-injury-induced-by-chronic-exposure-to-methamphetamine-in-rats
#16
Yang Bai, Yun Wang, Ming Liu, Yu-Han Gu, Bin Jiang, Xu Wu, Huai-Liang Wang
The imbalance between oxidative stress and antioxidant defense is important in the pathogenesis of lung diseases. Nuclear factor erythroid‑2‑related factor 2 (Nrf2) is a key transcriptional factor that regulates the antioxidant response. The purpose of the present study was to investigate whether Nrf2‑mediated antioxidative defense is involved in methamphetamine (MA)‑induced lung injury in rats. Following establishment of chronic MA toxicity in rats, Doppler ultrasonic detection was used to measure the changes of physiological indexes, followed by hematoxylin and eosin staining, ELISA and western blot analysis...
May 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28330826/the-influence-of-methamphetamine-on-maternal-behavior-and-development-of-the-pups-during-the-neonatal-period
#17
Mária Ševčíková, Ivana Hrebíčková, Eva Macúchová, Romana Šlamberová
Since it enters breast milk, methamphetamine (MA) abuse during lactation can not only affect the quality of maternal behavior but also postnatal development of pups. The aim of the present study was to examine the effect of injected MA (5mg/kg) on maternal behavior of rats and the differences in postnatal development, during postnatal days (PD) 1-11, of pups when the pups were directly exposed (i.e., injected) to MA or received MA indirectly via breast milk. Maternal behavior was examined using observation test (PD 1-22) and pup retrieval test (PD 1-12)...
March 19, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/28322983/the-relationship-between-fear-extinction-and-resilience-to-drug-dependence-in-rats
#18
Masaharu Ueno, Kazuo Yamada, Yukio Ichitani
Some individuals recover quickly from stressful events, while others do not; this suggests that there are individual differences in stress resilience. Previous studies in rats have shown that an animal's ability to extinguish conditioned fear can predict their stress resilience. In the present study, we investigated whether rats who are resilient or vulnerable to fear conditioning would consistently show resilient or vulnerable behaviors in other behavioral tests. Male Wistar-Imamichi rats were subjected to a series of behavioral tests, including open field, conditioned place-preference (CPP), forced swim and auditory fear conditioning...
March 18, 2017: Neuroscience Research
https://www.readbyqxmd.com/read/28303170/tbhq-alleviated-endoplasmic-reticulum-stress-apoptosis-and-oxidative-stress-by-perk-nrf2-crosstalk-in-methamphetamine-induced-chronic-pulmonary-toxicity
#19
Yun Wang, Yu-Han Gu, Ming Liu, Yang Bai, Li-Ye Liang, Huai-Liang Wang
Methamphetamine (MA) leads to cardiac and pulmonary toxicity expressed as increases in inflammatory responses and oxidative stress. However, some interactions may exist between oxidative stress and endoplasmic reticulum stress (ERS). The current study is designed to investigate if both oxidative stress and ERS are involved in MA-induced chronic pulmonary toxicity and if antioxidant tertiary butylhydroquinone (TBHQ) alleviated ERS-apoptosis and oxidative stress by PERK-Nrf2 crosstalk. In this study, the rats were randomly divided into control group, MA-treated group (MA), and MA plus TBHQ-treated group (MA + TBHQ)...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28301174/differential-characteristics-of-ketamine-self-administration-in-the-olfactory-bulbectomy-model-of-depression-in-male-rats
#20
Zuzana Babinska, Jana Ruda-Kucerova
Ketamine has been extensively studied for its antidepressant potential, with promising results in both preclinical and clinical studies. However, concerns regarding its abuse liabilities greatly limit its potential to become an approved treatment for depression. Therefore, a better understanding the risks and benefits of ketamine use in depression is needed. This study aimed to assess the characteristics of operant intravenous (IV) ketamine self-administration and relapse-like behavior in the olfactory bulbectomy (OBX) model of depression in male rats...
April 2017: Experimental and Clinical Psychopharmacology
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