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IMPROVE trial

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https://www.readbyqxmd.com/read/29471602/-evolving-therapeutic-strategies-in-the-inflammatory-bowel-disease
#1
REVIEW
Soo Young Na, Won Moon
It is important to have effective therapeutic strategies and goals in clinical practice and research of inflammatory bowel disease. Conventional end points for clinical trials in Crohn's disease and ulcerative colitis have been based on composite indices, such as the Crohn's Disease Activity Index and the Mayo Clinic Score. Although these indices have been shown to reduce the intestinal injury to some extent, satisfactory results have not been obtained in improving the quality of life of patients. Recently, alternative measures of outcome and definitions of response are being developed beyond symptoms...
February 25, 2018: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/29471572/-cardiovascular-medication-in-elderly-patients
#2
Robert H G Schwinger
Elderly people show increased probability to develop atherosclerotic diseases; in consequence heart failure - most often following coronary heart disease - as well as atrial fibrillation is more common. Following guidelines may lead to polypharmacy, i. e. use of more than 5 drugs daily. Thus, drug interactions as well as side effects become more likely; especially in elderly patients reduced kidney function has to be taken into account. Only drugs which have shown to prolong life or to reduce symptoms in controlled clinical trials should be used...
February 2018: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29471518/differences-between-supportive-music-and-imagery-and-music-listening-during-outpatient-chemotherapy-and-potential-moderators-of-treatment-effects
#3
Debra S Burns, Anthony N Meadows, Sandra Althouse, Susan M Perkins, Larry D Cripe
Background: Supportive music and imagery and music listening interventions have been effective in decreasing distress and improving mood in cancer patients receiving chemotherapy, but it is unclear whether the two interventions differ in their treatment benefits. Furthermore, previous studies have not examined moderators to determine which subgroup(s) of patients may benefit most from each intervention. Objective: To examine the effects of supportive music and imagery compared with preferred music listening on responsiveness to music therapy, distress, anxiety and depression, and benefit finding...
February 8, 2018: Journal of Music Therapy
https://www.readbyqxmd.com/read/29471478/internet-delivered-cognitive-behavioral-therapy-for-insomnia-in-breast-cancer-survivors-a-randomized-controlled-trial
#4
Robert Zachariae, Ali Amidi, Malene F Damholdt, Cecilie D R Clausen, Jesper Dahlgaard, Holly Lord, Frances P Thorndike, Lee M Ritterband
Background: Insomnia is two to three times more prevalent in cancer survivors than in the general population, where it is estimated to be 10% to 20%. Cognitive-behavioral therapy for insomnia (CBT-I) is the recommended treatment for chronic insomnia, but meeting survivor needs remains a challenge. Internet-delivered CBT-I (iCBT-I) has been shown efficacious in otherwise healthy adults. We tested the efficacy of iCBT-I in breast cancer survivors with clinically significant sleep disturbance...
February 20, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29471456/effects-of-resistance-training-endurance-training-and-whole-body-vibration-on-lean-body-mass-muscle-strength-and-physical-performance-in-older-people-a-systematic-review-and-network-meta-analysis
#5
Chih-Chin Lai, Yu-Kang Tu, Tyng-Guey Wang, Yi-Ting Huang, Kuo-Liong Chien
Background: A variety of different types of exercise are promoted to improve muscle strength and physical performance in older people. Objective: We aimed to determine the relative effects of resistance training, endurance training and whole-body vibration on lean body mass, muscle strength and physical performance in older people. Design: A systematic review and network meta-analysis. Subjects: Adults aged 60 and over...
February 17, 2018: Age and Ageing
https://www.readbyqxmd.com/read/29471442/estimation-of-adaptive-ventilation-success-and-failure-using-polysomnogram-and-outpatient-therapy-biomarkers
#6
Stacey Gunn, Sreelatha Naik, Matt Travis Bianchi, Robert Joseph Thomas
Study Objectives: Adaptive servo ventilation (ASV) devices provide anti-cyclic pressure support for treatment of central/complex sleep apnea, including in heart failure patients. Variability in responses in the clinic and negative clinical trials motivated assessment of standard and novel signal biomarkers for ASV efficacy. Methods: Multiple clinical databases were queried to assess potential signal biomarkers of ASV effectiveness, including 1) Attended laboratory adaptive ventilation titrations: 108, of which 66 had mainstream ETCO2 measurements...
February 17, 2018: Sleep
https://www.readbyqxmd.com/read/29471428/cognitive-behavioural-therapy-for-fear-of-falling-and-balance-among-older-people-a-systematic-review-and-meta-analysis
#7
Tai-Wa Liu, Gabriel Y F Ng, Raymond C K Chung, Shamay S M Ng
Background: fear of falling is prevalent among older people and associated with various health outcomes. A growing number of studies have examined the effects of interventions designed to reduce the fear of falling and improve balance among older people, yet our current understanding is restricted to physiological interventions. Psychological interventions such as cognitive behavioural therapy (CBT) have not been reviewed and meta-analysed. Objective: to perform a systematic review and meta-analysis evaluating the effects of CBT on reducing fear of falling and enhancing balance in community-dwelling older people...
February 20, 2018: Age and Ageing
https://www.readbyqxmd.com/read/29471412/interactions-between-the-concentration-of-non-starch-polysaccharides-in-wheat-and-the-addition-of-an-enzyme-mixture-in-a-broiler-digestibility-and-performance-trial
#8
N Smeets, F Nuyens, L Van Campenhout, E Delezie, T A Niewold
Two broiler trials were designed to investigate the relationship between the concentration of non-starch polysaccharides (NSP) in wheat and 1) its nutritional value for broilers and 2) the efficacy of exogenous enzymes. In a balance trial, diets were formulated with 3 wheat cultivars (Rustic and Viscount-medium NSP, Centenaire-high NSP) and were tested with or without the addition of an exogenous enzyme mixture. The diets were fed to 144 male Ross 308 broiler chickens housed in digestibility cages. Total tract nutrient digestibilities and AMEn were measured from 18 to 22 d of age...
February 16, 2018: Poultry Science
https://www.readbyqxmd.com/read/29471399/from-genome-wide-association-studies-to-mendelian-randomization-novel-opportunities-for-understanding-cardiovascular-disease-causality-pathogenesis-prevention-and-treatment
#9
Marianne Benn, Børge G Nordestgaard
The Mendelian randomization approach is an epidemiologic study design incorporating genetic information into traditional epidemiologic studies to infer causality of biomarkers, risk factors, or lifestyle factors on disease risk. Mendelian randomization studies often draw on novel information generated in genome-wide association studies on causal associations between genetic variants and a risk factor or lifestyle factor. Such information can then be used in a largely unconfounded study design free of reverse causation to understand if and how risk factors and lifestyle factors cause cardiovascular disease...
February 19, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/29471267/the-effectiveness-of-traditional-chinese-medicine-based-lifestyle-interventions-on-biomedical-psychosocial-and-behavioral-outcomes-in-individuals-with-type-2-diabetes-a-systematic-review-with-meta-analysis
#10
REVIEW
Xingfeng Yu, Janita P C Chau, Lanting Huo
BACKGROUND: Integrative diabetes care, which combines conventional diabetes therapy with traditional Chinese medicine (TCM)-based interventions, has gained popularity worldwide. Numerous TCM-based lifestyle modification approaches have been proposed for individuals with type 2 diabetes (T2DM). OBJECTIVES: To synthesize and present the best available evidence on the effectiveness of TCM-based lifestyle interventions in individuals with T2DM. DESIGN: We undertook a systematic review of randomized controlled trials or controlled clinical trials...
February 19, 2018: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29471162/hydrogen-peroxide-production-by-lactobacilli-promotes-epithelial-restitution-during-colitis
#11
Ashish K Singh, Rosanne Y Hertzberger, Ulla G Knaus
Inflammatory bowel disease (IBD) is a multifactorial chronic inflammatory disease of the gastrointestinal tract, characterized by cycles of acute flares, recovery and remission phases. Treatments for accelerating tissue restitution and prolonging remission are scarce, but altering the microbiota composition to promote intestinal homeostasis is considered a safe, economic and promising approach. Although probiotic bacteria have not yet fulfilled fully their promise in clinical trials, understanding the mechanism of how they exert beneficial effects will permit devising improved therapeutic strategies...
February 12, 2018: Redox Biology
https://www.readbyqxmd.com/read/29471124/methods-and-procedures-for-a-randomized-double-blind-study-investigating-dose-dependent-longitudinal-effects-of-vitamin-d-supplementation-on-bone-health
#12
Lauren A Burt, Sharon Gaudet, Michelle Kan, Marianne S Rose, Emma O Billington, Steven K Boyd, David A Hanley
The optimum dose of vitamin D and corresponding serum 25-hydroxyvitamin D (25OHD) concentration for bone health is still debated and some health practitioners are recommending doses well above the Canada/USA recommended Dietary Reference Intake (DRI). We designed a three-year randomized double-blind clinical trial investigating whether there are dose-dependent effects of vitamin D supplementation above the Dietary Reference Intake (DRI) on bone health. The primary aims of this study are to assess, whether supplementation of vitamin D3 increases 1) volumetric bone mineral density measured by high-resolution peripheral quantitative computed tomography (HR-pQCT); 2) bone strength assessed by finite element analysis, and 3) areal bone mineral density by dual X-ray absorptiometry (DXA)...
February 19, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29471069/what-s-technology-cooking-up-a-systematic-review-of-the-use-of-technology-in-adolescent-food-literary-programs
#13
REVIEW
Catherine A Wickham, Elena T Carbone
Over one-third of adolescents are overweight or obese. Food literacy (FL), the ability to plan and manage, select, prepare, and eat healthy foods, is a contemporary concept that provides a mechanism to understand the relationship between food-related knowledge and skills and dietary intake. Innovative interventions which focus on the core concepts of FL and include generationally appropriate technology have the potential to provide positive impact on the dietary habits of adolescents. This systematic review followed PRISMA guidelines and employed the Downs and Black criteria for rating studies...
February 19, 2018: Appetite
https://www.readbyqxmd.com/read/29471017/moderate-effects-of-noninvasive-brain-stimulation-of-the-frontal-cortex-for-improving-negative-symptoms-in-schizophrenia-meta-analysis-of-controlled-trials
#14
REVIEW
André Aleman, Stefanie Enriquez-Geppert, Henderikus Knegtering, Jozarni J Dlabac-de Lange
BACKGROUND: Negative symptoms in schizophrenia concern a clinically relevant reduction of goal-directed behavior that strongly and negatively impacts daily functioning. Existing treatments are of marginal effect and novel approaches are needed. Noninvasive neurostimulation by means of repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) are novel approaches that may hold promise. OBJECTIVES: To provide a quantitative integration of the published evidence regarding effects of rTMS and tDCS over the frontal cortex on negative symptoms, including an analysis of effects of sham stimulation...
February 19, 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29470838/first-line-cetuximab-monotherapy-in-kras-nras-braf-mutation-negative-colorectal-cancer-patients
#15
Vladimir M Moiseyenko, Fedor V Moiseyenko, Grigoriy A Yanus, Ekatherina Sh Kuligina, Anna P Sokolenko, Ilya V Bizin, Alexey A Kudriavtsev, Svetlana N Aleksakhina, Nikita M Volkov, Vyacheslav A Chubenko, Kseniya S Kozyreva, Mikhail M Kramchaninov, Alexandr S Zhuravlev, Kseniya V Shelekhova, Denis V Pashkov, Alexandr O Ivantsov, Aigul R Venina, Tatyana N Sokolova, Elena V Preobrazhenskaya, Natalia V Mitiushkina, Alexandr V Togo, Aglaya G Iyevleva, Evgeny N Imyanitov
BACKGROUND: Colorectal carcinomas (CRCs) are sensitive to treatment by anti-epidermal growth factor receptor (EGFR) antibodies only if they do not carry activating mutations in down-stream EGFR targets (KRAS/NRAS/BRAF). Most clinical trials for chemo-naive CRC patients involved combination of targeted agents and chemotherapy, while single-agent cetuximab or panitumumab studies included either heavily pretreated patients or subjects who were not selected on the basis of molecular tests...
February 22, 2018: Clinical Drug Investigation
https://www.readbyqxmd.com/read/29470807/longitudinal-effects-of-adjuvant-endocrine-therapy-on-the-quality-of-life-of-post-menopausal-women-with-non-metastatic-er-breast-cancer-a-systematic-review
#16
REVIEW
Hong Xiao, Xinyi Jiang, Cheng Chen, Alberto J Montero, Vakaramoko Diaby
BACKGROUND: Anti-estrogen (ER) endocrine therapy is an effective treatment strategy in reducing breast cancer mortality. This therapy has a better therapeutic index than chemotherapy but can still affect patients' quality of life (QOL) over time. OBJECTIVE: The objectives of this systematic review were to (1) describe QOL instruments used in ER-positive (ER+) non-metastatic breast cancer trials and (2) document the longitudinal effects of adjuvant endocrine therapy on the QOL of post-menopausal women with ER+ non-metastatic breast cancer...
February 22, 2018: PharmacoEconomics Open
https://www.readbyqxmd.com/read/29470804/effects-of-physical-exercise-on-breast-cancer-related-secondary-lymphedema-a-systematic-review
#17
REVIEW
F T Baumann, A Reike, V Reimer, M Schumann, M Hallek, D R Taaffe, R U Newton, D A Galvao
PURPOSE: The aim of this systematic review is to assess the effect of different types of exercise on breast cancer-related lymphedema (BCRL) in order to elucidate the role of exercise in this patient group. METHODS: A systematic data search was performed using PubMed (December 2016). The review is focused on the rehabilitative aspect of BCRL and undertaken according to the PRISMA statement with Levels of Evidence (LoE) assessed. RESULTS: 11 randomized controlled trials (9 with LoE 1a and 2 with LoE 1b) that included 458 women with breast cancer in aftercare were included...
February 22, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29470730/sacral-nerve-stimulation-versus-percutaneous-tibial-nerve-stimulation-for-faecal-incontinence-a-systematic-review-and-meta-analysis
#18
Constantinos Simillis, Nikhil Lal, Shengyang Qiu, Christos Kontovounisios, Shahnawaz Rasheed, Emile Tan, Paris P Tekkis
AIMS: Percutaneous tibial nerve stimulation (PTNS) and sacral nerve stimulation (SNS) are both second-line treatments for faecal incontinence (FI). To compare the clinical outcomes and effectiveness of SNS versus PTNS for treating FI in adults. METHOD: A literature search of MEDLINE, Embase, Science Citation Index Expanded and Cochrane was performed in order to identify studies comparing SNS and PTNS for treating FI. A risk of bias assessment was performed using The Cochrane Collaboration's risk of bias tool...
February 22, 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29470729/retromesenteric-course-of-the-middle-colic-artery-challenges-and-pitfalls-in-d3-right-colectomy-for-cancer
#19
Bojan V Stimec, Bjarte T Andersen, Stefan R Benz, Jean H D Fasel, Knut M Augestad, Dejan Ignjatovic
BACKGROUND: The middle colic artery (MCA) is of crucial importance in abdominal surgery, for laparoscopic or open right and transverse colectomies. Against this background, a high number of reports concerning anatomical variations of the MCA have been published intended to contribute to the improvement of operative techniques for the treatment of colon cancer. Despite this extensive literature, briefly reviewed in the present paper, a course of the MCA posterior to the superior mesenteric vein, called a retromesenteric trajectory, has been related to only once, to the best of our knowledge...
February 22, 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29470723/cyclin-dependent-kinase-4-6-inhibitors-as-first-line-treatment-for-post-menopausal-metastatic-hormone-receptor-positive-breast-cancer-patients-a-systematic-review-and-meta-analysis-of-phase-iii-randomized-clinical-trials
#20
Allan Ramos-Esquivel, Hellen Hernández-Steller, Marie-France Savard, Denis Ulises Landaverde
BACKGROUND: To compare the efficacy and toxicity of the combination of cyclin-dependent kinase 4/6 (CDK 4/6) inhibitors and nonsteroidal aromatase inhibitors (AI) versus AI alone as first-line therapy for patients with advanced hormone receptor-positive breast cancer. MATERIALS AND METHODS: Phase III randomized clinical trials (RCT) were identified after a systematic review of electronic databases. A random-effect model was used to determine the pooled hazard ratio (HR) for progression-free survival (PFS) using the inverse-variance method...
February 22, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
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