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https://www.readbyqxmd.com/read/28917718/olfactory-toxicity-in-rats-following-manganese-chloride-nasal-instillation-a-pilot-study
#1
Melanie L Foster, Deepa B Rao, Taylor Francher, Samantha Traver, David C Dorman
Following inhalation, manganese travels along the olfactory nerve from the olfactory epithelium (OE) to the olfactory bulb (OB). Occupational exposure to inhaled manganese is associated with changes in olfactory function. This pilot study evaluated two related hypotheses: (a) intranasal manganese administration increases OE and OB manganese concentrations; and (b) intranasal manganese exposure impairs performance of previously trained rats on a go-no-go olfactory discrimination (OD) task. Male Fischer 344 rats were trained to either lever press ("go") in response to a positive conditioned stimulus (CS+: vanillin) or to do nothing ("no go") when a negative conditioned stimulus (CS-: amyl acetate) was present...
September 13, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28913318/modified-anterior-craniofacial-osteotomy-using-partial-nasal-bone-division-and-reconstruction-in-frontoethmoidal-sinus-meningioma
#2
Eon Ju Park, Hong Il Kim, Jin Hyung Park, Hyung Suk Yi
Typical transcranial approaches are insufficient for adequate visualization and resection of skull base tumors. Different approaches with multiple modifications have been attempted. Here, we describe a new approach for a lesion that is central and hard to treat by conventional craniotomy and successful reconstruction with calvarial bone graft and titanium mesh plate. A 69-year-old female patient presented with recurrent meningioma. The tumor had invaded the frontal lobe, right supraorbital rim, and ethmoidal bone...
June 2017: Arch Craniofac Surg
https://www.readbyqxmd.com/read/28905843/orbital-dermatofibrosarcoma-protuberans-with-frontal-and-ethmoid-sinus-involvement-a-case-report-and-brief-review-of-literature
#3
Deepti Sharma, Garima Singh, Neha Kakkar, Vidya Jha
Dermatofibrosarcoma protuberans is a soft tissue sarcoma that is dermal in origin. The incidence is <0.1% of all malignancies and 1% of soft tissue sarcoma. Most commonly, it involves trunk (62%) followed by extremities (25%) and head and neck (13%). It is a slow growing tumor with locally aggressive behavior. Here, a 50-year-old female diagnosed with orbital dermatofibrosarcoma developed extra-axial component in right frontal region even on chemotherapy. Hence, the bad prognostic factors are yet to be established in dermatofibrosarcoma protuberans...
September 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28900497/pretreatment-nomograms-for-local-and-regional-recurrence-after-radical-radiation-therapy-for-primary-nasopharyngeal-carcinoma
#4
Fo-Ping Chen, Li Lin, Zhen-Yu Qi, Guan-Qun Zhou, Rui Guo, Jiang Hu, Ai-Hua Lin, Jun Ma, Ying Sun
Background: The aim of this study was to build nomograms to predict local recurrence (LR) and regional recurrence (RR) in patients with nasopharyngeal carcinoma (NPC) underwent intensity-modulated radiation therapy (IMRT). Patients and Methods : A total of 1811 patients with non-metastatic NPC treated with IMRT (with or without chemotherapy) between October 2009 and February 2012 at our center were involved for building the nomograms. Nomograms for LR-free rate and RR-free rate at 3- and 5- year were generated as visualizations of Cox proportional hazards regression models, and validated using bootstrap resampling, estimating discrimination and calibration...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28893971/computed-tomographic-assessment-of-equine-maxillary-cheek-teeth-anatomical-relationships-and-paranasal-sinus-volumes
#5
Tiziana Liuti, Richard Reardon, Paddy M Dixon
Disorders affecting the equine maxillary cheek teeth and paranasal sinuses are relatively common, but limited objective information is available on the dimensions and relationships of these structures in horses of different ages. The aims of this study were to assess age-related changes in the positioning and anatomical relationships of the individual maxillary cheek teeth with the infraorbital canal and maxillary septum and the volumes of the individual sinus compartments. CT and gross examination were performed on 60 normal equine cadaver heads that were aged by their dentition...
September 11, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28891427/in-reference-to-analysis-of-the-relationship-between-the-location-of-the-anterior-ethmoid-artery-and-keros-classification
#6
Hyun Jin Min, Kyung Soo Kim
No abstract text is available yet for this article.
September 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28891426/in-reference-to-analysis-of-the-relationship-between-the-location-of-the-anterior-ethmoid-artery-and-keros-classification-reply
#7
Alissa Kanaan
No abstract text is available yet for this article.
September 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28882714/combined-minimally-invasive-supraciliary-and-transfacial-approach-for-large-tumors-with-skull-base-and-sinonasal-involvement
#8
Pal Barzo, Zsolt Zador, Mihaly Bodosi, Zsolt Bella, Daniel Jambor, Bela Fulop, Jeno Czigner
BACKGROUND: Tumors invading both the anterior skull base and the sinonasal area have been traditionally accessed via largely invasive open craniofacial approaches. Minimally invasive extended endoscopic endonasal approaches have recently become increasingly available, but have anatomical limitations and require incremental experience and thus high patient volume. Our objective was to assess the applicability of a novel combination of the minimally invasive supraciliary incision and the limited maxillofacial osteotomy as a combined surgical approach for large tumors invading both the anterior skull base and the sinonasal area...
September 4, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28872506/an-aneurysmal-bone-cyst-in-the-skull-base
#9
Sangjun Kim, Dong Won Jung, Min Gyoung Pak, Young Jin Song, Woo Yong Bae
An aneurysmal bone cyst (ABC) is believed to be attributable to intraosseous circulatory disturbance. An ABC is a vascular tumor of the bone caused by bony expansion after partial vascular occlusion and congestion. Most ABCs are found in adolescents (approximately 75% of ABCs are observed in patients under 20 years of age). The most common ABC sites are the long bones of the limbs, the vertebrae, and the cranial bone. Aneurysmal bone cysts in the skull base or ethmoid sinus have been but rarely reported worldwide...
September 1, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28860916/dermis-fat-graft-for-pediatric-exenteration-challenging-but-rewarding
#10
Himika Gupta, Deepa Nair, Aliasgar Moiyadi, Prathamesh Pai
Orbital exenteration is a destructive and disfiguring surgery and involves removal of the entire orbital contents, soft tissue and often lids as well. We report a case of an eight month old female, with malignant orbital teratoma who underwent lid sparing exenteration for the destructive, locally advanced disease. Three month post surgery she developed recurrence with intracranial extension as well as socket infection with pus discharge. Repeat surgery involved a multispeciality approach for removal of the tumor which was abutting the cavernous sinus posteriorly and ethmoid sinus medially, apart from filling the entire bony orbit...
July 2017: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/28859993/on-ciprofloxacin-concentration-in-chronic-rhinosinusitis
#11
José Gameiro Dos Santos, Rosário Figueirinhas, José P Liberal, João C Almeida, Joana Sousa, Amílcar Falcão, Corália Vicente, João Paço, Cecília A Sousa
OBJECTIVE: Considering that all the evidence indicates that chronic rhinosinusitis without nasal polyps (CRSsNP) and chronic rhinosinusitis with nasal polyps (CRSwNP) are distinct entities, the aim of this study was to compare the concentrations obtained in plasma and in sinonasal mucosa with oral and nasal topical ciprofloxacin, in patients with and without nasal polyps, without evaluating the effectiveness of the use of an antibiotic. METHODS: Prospective clinical study with single-blind randomization...
August 28, 2017: Acta Otorrinolaringológica Española
https://www.readbyqxmd.com/read/28859706/outcomes-of-sinonasal-squamous-cell-carcinoma-with-and-without-association-of-inverted-papilloma-a-multi-institutional-analysis
#12
Brian C Lobo, Brian D'Anza, Janice L Farlow, Dennis Tang, Troy D Woodard, Jonathan Y Ting, Raj Sindwani
INTRODUCTION: Sinonasal squamous cell carcinoma (SCC) accounts for <1% of all malignancies but represents 70% of sinonasal cancer. Up to 10% of SCCs are associated with inverted papilloma (IPSCC). Studies that compare patients, treatment, and outcomes of SCC and IPSCC are absent in the literature. METHODS: A retrospective review of patients with SCC and those with IPSCC at Cleveland Clinic and Indiana University from 1995 to 2015. The records were analyzed for demographics, tumor characteristics, treatment, and outcomes...
September 1, 2017: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/28859244/significance-of-human-papillomavirus-positivity-in-sinonasal-squamous-cell-carcinoma
#13
Suat Kılıç, Sarah S Kılıç, Emilie S Kim, Soly Baredes, Omar Mahmoud, Stacey T Gray, Jean Anderson Eloy
BACKGROUND: The role of human papillomavirus (HPV) in sinonasal squamous cell carcinoma (SNSCC) is not well understood. METHODS: The National Cancer Database was queried for cases of SNSCC with known HPV status. Demographics, socioeconomic variables, TNM stage, histology, grade, treatment modalities, and overall survival (OS) through 5 years were compared between HPV-positive and HPV-negative tumors. Cox proportional hazard regression analyses were performed. RESULTS: Seven hundred seventy (770) cases were identified; 526 were HPV-negative (68...
August 31, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28845040/surgical-anatomy-for-the-endoscopic-endonasal-approach-to-the-ventrolateral-skull-base
#14
Kenichi Oyama, Shigeyuki Tahara, Toshio Hirohata, Yudo Ishii, Daniel M Prevedello, Ricardo L Carrau, Sebastien Froelich, Akira Teramoto, Akio Morita, Akira Matsuno
The authors describe the surgical anatomy for the endoscopic endonasal approach (EEA) to the ventrolateral skull base. The ventrolateral skull base can be divided into two segments: the upper lateral and lower lateral skull base. The upper lateral skull base includes the cavernous sinus and the orbit, while the lower lateral skull base includes the petrous apex, Meckel's cave, parapharyngeal space, infratemporal fossa, etc. To gain access to the upper lateral skull base, a simple opening of the ethmoid sinus provides sufficient exposure of this area...
August 25, 2017: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/28837389/basaloid-adenocarcinoma-of-the-lacrimal-sac-a-rare-entity-and-approach-to-management
#15
Alison B Huggins, Mary A Stefanyszyn, Gurston Nyquist, Michael P Rabinowitz
Presented is a rare case of basaloid adenocarcinoma of the lacrimal sac. Low grade features of this malignancy permitted a conservative surgical approach to maximize functional and cosmetic outcomes. This is retrospective case description of a single 77-year-old-female patient who underwent a dacryocystorhinostomy with silicone tubes at an outside hospital for epiphora, but was referred to the Wills Eye Hospital Oculoplastics Department for a lacrimal sac biopsy showing low-grade carcinoma with basaloid features...
August 24, 2017: Orbit
https://www.readbyqxmd.com/read/28834831/the-new-anatomical-classification-system-for-orbital-exenteration-defect
#16
Can Cinar, Hakan Arslan, Ugur Anil Bingol, Yagmur Aydin, Oguz Cetinkale
BACKGROUND: The unique anatomy of the orbita and the different behavior of each malignant tumor cause us to perform the various types of orbital exenteration that yields to varying defect each of which has own specific demands in terms of the reconstruction. Current classification of orbital exenteration defects seems not to be adequate to provide detailed description. This study reviews 50 exenteration defects to offer a more effective anatomical classification system. METHODS: Over a 15 years period, 50 orbital exenteration defects in 47 patients were reconstructed...
August 22, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28834303/radioanatomic-study-of-the-skull-base-and-septum-in-asians-implications-for-using-the-nasoseptal-flap-for-anterior-skull-base-reconstruction
#17
Sung Joon Park, Hyun-Jik Kim, Dong-Young Kim, Chae-Seo Rhee, Chul Hee Lee, Sun Ha Paek, Tae-Bin Won
BACKGROUND: The objective of this work was to assess the feasibility of using the nasoseptal flap (NSF) for covering the anterior skull-base defect in Asians, and to compare the results in whites. METHODS: A retrospective radioanatomic analysis was conducted in 100 Korean adult patients. Septal and skull-base dimensions were measured and the feasibility of the NSF in reconstructing a full anterior skull-base defect was evaluated. Scans of 49 white patients were analyzed for a comparative study...
August 21, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28830313/characteristics-of-sinonasal-fibrous-dysplasia-experience-from-a-single-department
#18
Chen Duan, Qi Dai, Quan Liu, Hongmeng Yu
OBJECTIVES: We summarized the characteristics of fibrous dysplasia patients in our department to obtain clinical data on this disease. METHODS: We retrospectively reviewed 28 patients who were diagnosed with sinonasal fibrous dysplasia based on pathological examination results from March 2012 to February 2017 in our department. RESULTS: The 28 patients included 16 females and 12 males, and the median age was 31.5 (range, 7-69) years. The three most common symptoms were nasal obstruction (25%), impaired vision (21%) and headache (18%)...
August 22, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28807454/reconsidering-olfactory-bulb-magnetic-resonance-patterns-in-kallmann-syndrome
#19
Thomas Hacquart, Aïcha Ltaief-Boudrigua, Cécile Jeannerod, Salem Hannoun, Gérald Raverot, Michel Pugeat, Aude Brac de la Perriere, Véronique Lapras, Frédérique Nugues, Catherine Dode, Francois Cotton
OBJECTIVE: The aim of this retrospective study was to perform magnetic resonance imaging assessment of olfactory pathway and skull base abnormalities in Kallmann syndrome (KS) patients with hypogonadotropic hypogonadism and olfaction disorder. METHODS: Magnetic resonance brain patterns were retrospectively studied in 19 patients clinically classified as KS. Qualitative assessment of olfactory bulb region comprised bulb atrophy and rectus and medial orbital gyrus ptosis; quantitative assessment measured olfactory fossa depth and width, sulcus depth and ethmoid angle...
August 11, 2017: Annales D'endocrinologie
https://www.readbyqxmd.com/read/28806382/orbital-cellulitis-following-orbital-blow-out-fracture
#20
Je Yeon Byeon, Hwan Jun Choi
Orbital cellulitis and abscess have been described in the literature as complication that usually occur secondary to infection in the maxillary, ethmoidal, and frontal sinuses. If left untreated, it can lead to blindness, cavernous sinus thrombosis, meningitis, or cerebral abscess. Orbital fractures are a common sequela of blunt orbital trauma, but are only rarely associated with orbital cellulitis. So, the authors present rare orbital cellulitis after orbital blow-out fracture. A 55-year-old Asian complains of severe orbital swelling and pain on the left side...
August 10, 2017: Journal of Craniofacial Surgery
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