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https://www.readbyqxmd.com/read/28523041/functional-endoscopic-sinus-surgery-as-a-primary-modality-of-treatment-for-primary-and-recurrent-nasal-polyposis
#1
Mohammad Shahid Gohar, Saleem Asif Niazi, Sohail Baber Niazi
OBJECTIVES: To describe the efficacy of Functional Endoscopic Sinus Surgery(FESS) in our set up in comparison with other published studies to treat primary and recurrent nasal polyposis. METHOD: This descriptive study was conducted in 02 years at Ear Nose Throat Department Combined Military Hospital (CMH) Multan from October 2013 to October 2015. Convenient sample comprising 116 patients of both sexes of age group from 18 to 60 years were selected from ENT Out Patient Department, with documented diagnosis of nasal polyposis that underwent functional endoscopic sinus surgery...
March 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28521083/inflammatory-infiltrate-and-mucosal-remodeling-in-chronic-rhinosinusitis-with-and-without-polyps-structured-histopathologic-analysis
#2
Hannah N Kuhar, Bobby A Tajudeen, Mahboobeh Mahdavinia, Paolo Gattuso, Ritu Ghai, Pete S Batra
BACKGROUND: Chronic rhinosinusitis (CRS) is commonly classified into CRS with nasal polyps (CRSwNP) and CRS without nasal polyps (CRSsNP). Structured histopathologic reporting has the potential to identify salient histologic markers to differentiate subtypes and provide insights into pathophysiologic mechanisms in CRS. METHODS: A structured histopathology report of 13 variables was prospectively employed to analyze ethmoid sinus tissue removed during endoscopic sinus surgery for 99 patients, including 43 CRSsNP and 56 CRSwNP...
May 18, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28512741/intervention-for-elevated-intracranial-pressure-improves-success-rate-after-repair-of-spontaneous-cerebrospinal-fluid-leaks
#3
William Teachey, Jessica Grayson, Do-Yeon Cho, Kristen O Riley, Bradford A Woodworth
OBJECTIVES/HYPOTHESIS: Spontaneous cerebrospinal fluid (CSF) leaks are associated with increased intracranial pressure (ICP) and considered a manifestation of idiopathic intracranial hypertension. Although postoperative acetazolamide and placement of CSF shunt systems are considered valuable interventions for elevated ICP, the impact on recurrence rate remains unclear. The objective of this study was to systematically review evidence from reported literature to evaluate whether postoperative ICP management reduces recurrence rates after primary endoscopic repair...
May 16, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28512505/chronic-invasive-fungal-sinusitis-presenting-as-inferior-altitudinal-visual-field-defect
#4
Reema Bansal, Aastha Takkar, Vivek Lal, Amanjit Bal, Sandeep Bansal
A young male with acute blurring of vision (6/9) complained of an inferior altitudinal field defect in right eye. Clinical ophthalmological examination was normal. Magnetic resonance imaging (MRI) of the brain revealed the expansion and mucosal thickening of right posterior ethmoid and sphenoid sinuses and opacified right maxillary sinus. Surgical intervention (transethmoidal sphenoidotomy) and histopathological examination revealed chronic invasive granulomatous fungal sinusitis. Anti-fungal therapy led to resolution of visual complaints and restoration of visual field defects...
June 2017: Neuro-ophthalmology
https://www.readbyqxmd.com/read/28508924/intractable-epistaxis-which-arteries-are-responsible-an-angiographic-study
#5
Guillaume de Bonnecaze, Y Gallois, P Chaynes, F Bonneville, A Dupret-Bories, E Chantalat, E Serrano
PURPOSE: Epistaxis constitutes a significant proportion of the Otolaryngologist's emergency workload. Optimal management differs in relation to the anatomic origin of the bleeding. The outcome of our study was to determine which artery(ies) could be considered as the cause of severe bleeding in the context of severe epistaxis. METHODS: Fifty-five procedures of embolization preceded by angiography were reviewed. Medical records of interventionally treated patients were analysed for demographics, medical history, risk factors and clinical data...
May 16, 2017: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/28492612/a-prospective-randomized-clinical-study-comparing-drug-eluting-stent-therapy-and-intranasal-corticoid-steroid-therapy-in-the-treatment-of-patients-with-chronic-rhinosinusitis
#6
R Taulu, A J Bizaki, J Numminen, M Rautiainen
OBJECTIVES: To conduct the first prospective, randomized controlled clinical trial comparing the efficacy of a drug-eluting stent (DES) (the Relieva StratusTM MicroFlow Spacer) and topical intranasal corticosteroid therapy in patients with chronic rhinosinusitis (CRS). METHODS: Sixty-three adult patients with ethmoiditis were randomized into either the DES group (n=34) or nasal spray group (n=29). The main outcome variable was the Sinonasal Outcome Test 22, Visual Analogue Scale, nasal endoscopy, rhinometric measurements were performed at the beginning of the study, after three months and six months of follow-up...
May 10, 2017: Rhinology
https://www.readbyqxmd.com/read/28490402/international-frontal-sinus-anatomy-classification-and-anatomic-predictors-of-low-lying-anterior-ethmoidal-arteries
#7
Phayvanh P Sjogren, Rajendra Waghela, Shaelene Ashby, Richard H Wiggins, Richard R Orlandi, Jeremiah A Alt
BACKGROUND: The International Frontal Sinus Anatomy Classification (IFAC) was introduced to more accurately characterize ethmoid and frontal sinus pneumatization patterns. The prevalence of IFAC cells and their anatomic associations have not been described. OBJECTIVE: The goal was to examine the prevalence of IFAC cells and determine radiologic features associated with a low-lying anterior ethmoidal artery (LAEA). METHODS: Imaging of adult patients who underwent computed tomographies from January 2015 to March 2016 were retrospectively reviewed by using the IFAC classification...
May 1, 2017: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/28485287/clinical-outcomes-of-treatment-of-sinonasal-inverted-papillomas-ips-depending-on-the-surgical-technique-and-learning-curve
#8
Roland Zydroń, Małgorzata Wierzbicka, Grażyna Greczka
INTRODUCTION: Sinonasal inverted papillomas (IPs) are a major challenge for ENT specialists. In the last decades, the number of endoscopic procedures has increased, while the percentage of external or double approach procedures has decreased. The aim of this study was to evaluate long-term IP treatment outcomes according to the applied surgical method. MATERIAL AND METHODS: the retrospective study included 69 patients (28 women and 41 men) treated during 2002-2012 in the Department of Otolaryngology and Laryngological Oncology of Poznań University of Medical Sciences...
November 20, 2016: Otolaryngologia Polska
https://www.readbyqxmd.com/read/28483236/the-prevalence-of-the-onodi-cell-most-suitable-method-of-ct-evaluation-in-its-detection
#9
L P Chmielik, A Chmielik
BACKGROUND: The Onodi cell (sphenoethmoidal air cell) is an anatomic variant of the most posterior ethmoid cell that pneumatised superiorly and laterally to the sphenoid sinus, and is in close relation to the optic nerve. The proper identification of the Onodi cell is essential during a pre-operative computer tomography (CT) examination, as the presence of that ethmoid cell variant makes sphenoid sinus surgery more risky. The bulging of the optic nerve to the ethmoid cell wall is well visualized during endoscopic examination, but there are no clearly defined criteria for a potentially dangerous Onodi cell type in CT examinations...
June 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28481397/endoscopic-endonasal-cerebrospinal-fluid-leak-repair-on-the-ventral-midline-skull-base-a-single-neurosurgical-center-experience
#10
Cihan Isler, Merdin Lyutviev Ahmedov, Mehmet Yigit Akgun, Baris Kucukyuruk, Nurperi Gazioglu, Galip Sanus, Necmettin Tanriover
AIM: The aim of this study was to present the results of endoscopic endonasal repair of ventral midline skull base cerebrospinal fluid (CSF) leak (VMSBL) at our institution and to discuss the technique and results from a neurosurgical perspective. MATERIAL AND METHODS: A retrospective analysis of all VMSBL cases that underwent endoscopic endonasal skull base approach (EESBA) for CSF leak repair at a single tertiary neurosurgical center was performed. Twenty six patients with an average age of 44...
March 25, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/28474861/group-2-innate-lymphoid-cells-are-elevated-and-activated-in-chronic-rhinosinusitis-with-nasal-polyps
#11
Julie A Poposki, Aiko I Klingler, Bruce K Tan, Pejman Soroosh, Homayon Banie, Gavin Lewis, Kathryn E Hulse, Whitney W Stevens, Anju T Peters, Leslie C Grammer, Robert P Schleimer, Kevin C Welch, Stephanie S Smith, David B Conley, Joseph R Raviv, James G Karras, Omid Akbari, Robert C Kern, Atsushi Kato
BACKGROUND: Chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) is characterized by type 2 inflammation with high levels of Th2 cytokines. Although T helper cytokines are released from T cells, innate lymphoid cells (ILC) are also known to produce high levels of the same cytokines. However, the presence of various types of ILC in CRS is poorly understood. OBJECTIVE: The objective of this study was to fully characterize the presence of all ILC subsets in CRS and to identify phenotypical differences of group 2 ILC (ILC2) in CRSwNP compared to ILC2 from non-type 2 inflamed areas...
April 19, 2017: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/28468156/the-management-of-the-paranasal-sinus-osteomas
#12
Hasan Hüseyin Arslan, Hamdi Tasli, Süleyman Cebeci, Mustafa Gerek
OBJECTIVE: Osteoma is the most common benign tumor of the paranasal sinuses. The clinical characteristics and treatment of this disease remain controversial. The aim of this study is to determine the appropriate method of treatment approach according to the features of osteomas. METHODS: Forty-one patients with paranasal sinus osteomas were included in the study. According to the location and the size of tumors, patients were followed up or operated. Surgical treatment was performed via external, endoscopic, or combined approaches for symptomatic patients...
May 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28465271/endoscopic-superior-ethmoidal-approach-for-anterior-cranial-base-resection-tailoring-the-approach-for-maximum-exposure-with-preservation-of-nasal-structures
#13
Maria Peris Celda, Tyler Kenning, Carlos D Pinheiro-Neto
OBJECTIVE: The traditional endoscopic anterior cranial base resection involves total removal of the ethmoidal cells including middle and superior turbinates. This is associated with increased volume of the nasal cavity postoperatively with more crusting and permanent change of the nasal airflow. The objective is to describe the step-by-step technique and feasibility of the superior ethmoidal approach for anterior cranial base resection with maximum exposure of the anterior cranial base maintaining the middle turbinates, uncinate processes and ostiomeatal complexes intact...
April 29, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28464955/il-5-and-il-6-are-increased-in-the-frontal-recess-of-eosinophilic-chronic-rhinosinusitis-patients
#14
Kazunori Kubota, Sachio Takeno, Takayuki Taruya, Atsushi Sasaki, Takashi Ishino, Katsuhiro Hirakawa
BACKGROUND: Eosinophilic chronic frontal sinusitis is difficult to treat compared with non-eosinophilic sinusitis because of recurring inflammation and polyp formation in the frontal recess after the post-operative follow-up period. Studying inflammatory mediators in the frontal recess of eosinophilic chronic rhinosinusitis (ECRS) patients and non-eosinophilic chronic rhinosinusitis (non-ECRS) patients may lead to a better understanding of the pathogenesis of chronic frontal sinusitis...
May 2, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28460847/radiographic-evidence-of-sinonasal-inflammation-in-asthma-chronic-obstructive-pulmonary-disease-overlap-syndrome-an-underrecognized-association
#15
Satoshi Hamada, Shuji Tatsumi, Yoshiki Kobayashi, Hisako Matsumoto, Hirotaka Yasuba
BACKGROUND: Sinonasal inflammation on both clinical examinations and imaging significantly impacts both asthma and chronic obstructive pulmonary disease (COPD). OBJECTIVE: The objective of this study was to examine the association between sinonasal inflammation and asthma-COPD overlap syndrome (ACOS). METHODS: A total of 112 patients with a ratio of forced expiratory volume in 1 s to forced vital capacity of less than 70% were enrolled. COPD, asthma, and ACOS were clinically diagnosed according to the 2014 Global Initiative for Asthma and Global Initiative for Chronic Obstructive Lung Disease guidelines...
April 28, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28452704/nitric-oxide-production-is-stimulated-by-bitter-taste-receptors-ubiquitously-expressed-in-the-sinonasal-cavity
#16
Carol H Yan, Samuel Hahn, Derek McMahon, David Bonislawski, David W Kennedy, Nithin D Adappa, James N Palmer, Peihua Jiang, Robert J Lee, Noam A Cohen
BACKGROUND: Bitter taste receptors (T2R) have recently been demonstrated to contribute to sinonasal innate immunity. One T2R, T2R38, regulates mucosal defense against gram-negative organisms through nitric oxide (NO) production, which enhances mucociliary clearance and directly kills bacteria. To determine whether additional T2Rs contribute to this innate defense, we evaluated two other sinonasal T2Rs (T2R4 and T2R16) for regulation of NO production and expression within the human sinonasal cavity...
March 1, 2017: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/28450118/importance-of-deubiquitinases-in-zebrafish-craniofacial-development
#17
William Ka Fai Tse
Deconjugation of ubiquitin and/or ubiqutin-like modified substrates is essential to maintain a sufficient free ubiquitin within the cell. Deubiquitinases (DUBs) play a key role in the process. Besides, DUBs also play several important regulatory roles in cellular processes. However, our knowledge of their developmental roles are limited. The report here aims to study their potential roles in craniofacial development. Based on the previous genome-wide study in 2009, we selected 36 DUBs to perform the morpholino (MO) knockdown in this study, followed by the Alcian blue cartilage staining at 5 days post-fertilization (dpf) larvae to investigate the facial development...
June 10, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28449210/middle-meatal-packing-in-endoscopic-sinus-surgery-to-pack-or-not-to-pack-a-decision-analysis-model
#18
Sagit Stern-Shavit, Yuval Nachalon, Moshe Leshno, Ethan Soudry
BACKGROUND: Packing of the middle meatus and ethmoid cavities is a common practice in endoscopic sinus surgery (ESS), but its necessity recently has been challenged. The aim of this study was to formulate a decision-analysis model to determine the need for packing in ESS and identify variables affecting the decision. METHODS: A systematic review of the literature was conducted for all randomized control trials comparing packing to no packing in ESS, and a decision-analysis model was generated...
April 27, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28447154/radiological-and-clinical-interpretation-of-the-patients-with-csf-leaks-developed-during-or-after-endoscopic-sinus-surgery
#19
Muaid I Aziz Baban, Mokarbesh Hadi, Stefania Gallo, Jacopo Zocchi, Mario Turri-Zanoni, Paolo Castelnuovo
Cerebrospinal fluid (CSF) leaks associated with endoscopic sinus surgery (ESS) are a rare complication related to anatomical and technical factors. The anatomical variations at skull base level are imperative to be detected preoperatively by CT scan to avoid this complication. Identifying the factors playing a role in the incidence of the CSF leaks during and after ESS and the common leak sites. A retrospective review of 24 patients presented with incidental CSF leaks, gathered from 1999 to 2016 was performed...
April 26, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28446994/frequency-and-volumetry-of-infraorbital-ethmoid-cells-haller-cells-on-cone-beam-computed-tomograms-cbct-of-the-mid-face
#20
Reinhard E Friedrich, Meike Fraederich, Gerhard Schoen
Objective: The aim of this study was to determine the frequency and morphology of Haller cells using a new radiological technique that allows examination of the facial skull. Material and methods: In a single center retrospective cohort study the cone-beam computed tomography (CBCT) volume data of the maxillary sinus of 199 patients were analysed (398 paranasal sinuses). If Haller cells were found, their capacity was determined. If orthopantomograms (OPG) were taken in a narrow time frame around the CBCT investigation, the rate of correspondence of the radiological findings was determined...
2017: GMS Interdisciplinary Plastic and Reconstructive Surgery DGPW
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