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Familial Cushing's Disease

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https://www.readbyqxmd.com/read/27588171/gene-mutations-in-cushing-s-disease
#1
Qi Xiong, Wei Ge
Cushing's disease (CD) is a severe (and potentially fatal) disease caused by adrenocorticotropic hormone (ACTH)-secreting adenomas of the pituitary gland (often termed pituitary adenomas). The majority of ACTH-secreting corticotroph tumors are sporadic and CD rarely appears as a familial disorder, thus, the genetic mechanisms underlying CD are poorly understood. Studies have reported that various mutated genes are associated with CD, such as those in menin 1, aryl hydrocarbon receptor-interacting protein and the nuclear receptor subfamily 3 group C member 1...
September 2016: Biomedical Reports
https://www.readbyqxmd.com/read/27580546/a-novel-mutation-in-the-type-i%C3%AE-regulatory-subunit-of-protein-kinase-a-prkar1a-in-a-cushing-s-syndrome-patient-with-primary-pigmented-nodular-adrenocortical-disease
#2
Ryohei Mineo, Sachiko Tamba, Yuya Yamada, Tomonori Okita, Yusuke Kawachi, Reiko Mori, Mitsuaki Kyo, Kenji Saisho, Yohei Kuroda, Koji Yamamoto, Akiko Furuya, Tokuo Mukai, Takashi Maekawa, Yasuhiro Nakamura, Hironobu Sasano, Yuji Matsuzawa
A 40-year-old man presented with Cushing's syndrome due to bilateral adrenal hyperplasia with multiple nodules. Computed tomography scan results were atypical demonstrating an enlargement of the bilateral adrenal glands harboring multiple small nodules, but the lesion was clinically diagnosed to be primary pigmented nodular adrenocortical disease (PPNAD) based on both endocrinological test results and his family history. We performed bilateral adrenalectomy and confirmed the diagnosis histologically. An analysis of the patient and his mother's genomic DNA identified a novel mutation in the type Iα regulatory subunit of protein kinase A (PRKAR1A) gene; p...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27471492/mouse-models-recapitulating-human-adrenocortical-tumors-what-is-lacking
#3
REVIEW
Felicia Leccia, Marie Batisse-Lignier, Isabelle Sahut-Barnola, Pierre Val, A-Marie Lefrançois-Martinez, Antoine Martinez
Adrenal cortex tumors are divided into benign forms, such as primary hyperplasias and adrenocortical adenomas (ACAs), and malignant forms or adrenocortical carcinomas (ACCs). Primary hyperplasias are rare causes of adrenocorticotropin hormone-independent hypercortisolism. ACAs are the most common type of adrenal gland tumors and they are rarely "functional," i.e., producing steroids. When functional, adenomas result in endocrine disorders, such as Cushing's syndrome (hypercortisolism) or Conn's syndrome (hyperaldosteronism)...
2016: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/27403928/a-novel-phenotype-of-familial-hyperaldosteronism-type-iii-concurrence-of-aldosteronism-and-cushing-s-syndrome
#4
Anli Tong, Guanghua Liu, Fen Wang, Jun Jiang, Zhaoli Yan, Dianxi Zhang, Yinsheng Zhang, Jun Cai
CONTEXT: To date, all the familial hyperaldosteronism type III (FH-III) patients reported presenting with typical primary aldosteronism (PA), without showing other adrenal hormone abnormalities. OBJECTIVE: This study characterized a novel phenotype of FH-III and explored the possible pathogenesis. PATIENTS AND METHODS: A male patient presented with severe hypertension and hypokalemia at the age of 2 years and developed Cushing's syndrome at 20 years...
November 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27306888/do-patients-with-incidentally-discovered-bilateral-adrenal-nodules-represent-an-early-form-of-armc5-mediated-bilateral-macronodular-hyperplasia
#5
Holly Emms, Ioanna Tsirou, Treena Cranston, Stylianos Tsagarakis, Ashley B Grossman
Bilateral adrenal macronodular hyperplasia (BMAH) is a rare form of Cushing's syndrome characterised by the presence of bilateral secretory adrenal nodules and hypercortisolism. Familial studies support a genetic basis for BMAH, and the disease has been linked to mutations in ARMC5, a gene shown to have a tumour suppressor-like action in the development of adrenal nodules. This study aimed to investigate whether ARMC5 mutations play a role in the development of incidentally discovered bilateral adrenal nodules...
September 2016: Endocrine
https://www.readbyqxmd.com/read/27065461/use-of-3-dimensional-volumetric-modeling-of-adrenal-gland-size-in-patients-with-primary-pigmented-nodular-adrenocortical-disease
#6
P P Chrysostomou, M B Lodish, E B Turkbey, G Z Papadakis, C A Stratakis
Primary pigmented nodular adrenocortical disease (PPNAD) is a rare type of bilateral adrenal hyperplasia leading to hypercortisolemia. Adrenal nodularity is often appreciable with computed tomography (CT); however, accurate radiologic characterization of adrenal size in PPNAD has not been studied well. We used 3-dimensional (3D) volumetric analysis to characterize and compare adrenal size in PPNAD patients, with and without Cushing's syndrome (CS). Patients diagnosed with PPNAD and their family members with known mutations in PRKAR1A were screened...
April 2016: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/27050894/a-rare-case-of-subclinical-primary-aldosteronism-and-subclinical-cushing-s-syndrome-without-cardiovascular-complications
#7
Natsumi Kitajima, Toshiro Seki, Atsushi Yasuda, Masayuki Oki, Atsushi Takagi, Kazuya Hanai, Toshiro Terachi, Masafumi Fukagawa
We report a rare case of subclinical primary aldosteronism (PA) and subclinical Cushing's syndrome (CS). A 49-year-old woman was referred to our hospital for the evaluation of an adrenal incidentaloma. The patient had no previous medical history and no family history of notable illness. Her blood pressure was 103/60 mmHg. She had no Cushingoid features. Routine laboratory examinations were within the normal ranges including normokalemia. Based on the endocrinological results and imaging findings, we finally made a diagnosis of subclinical PA caused by both adrenal glands and subclinical CS caused by bilateral adrenal tumors...
April 2016: Tokai Journal of Experimental and Clinical Medicine
https://www.readbyqxmd.com/read/27027905/health-related-quality-of-life-and-parental-stress-in-children-with-fecal-incontinence-a-normative-comparison
#8
Christopher C Cushing, Bruno Martinez-Leo, Andrea Bischoff, Jennifer Hall, Michael Helmrath, Belinda H Dickie, Marc A Levitt, Alberto Peña, Meg H Zeller, Jason S Frischer
OBJECTIVE: The aim of the present study was to describe the quality of life and parenting stress associated with a child with fecal incontinence (FI). METHODS: Female caregivers (n = 170) of children of 3 to 12 years age with FI completed a broad and general measure of quality of life and a measure of parenting stress. Results were compared with proxy reports for a normative sample of healthy children. RESULTS: Caregivers of children with FI reported significantly impaired quality of life for their children and increased parenting stress in all of the respective domains relative to healthy controls...
December 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/26619967/prkar1a-negative-familial-cushing-s-syndrome-two-case-reports
#9
Lee Ling Lim, Normayah Kitan, Sharmila Sunita Paramasivam, Jeyakantha Ratnasingam, Luqman Ibrahim, Siew Pheng Chan, Alexander Tong Boon Tan, Shireene Ratna Vethakkan
INTRODUCTION: Determining the etiology of Cushing's syndrome is very challenging to endocrinologists, with most of the difficulty arising from subtype differentiation of adrenocorticotropic hormone-dependent Cushing's syndrome. We present the pitfalls of evaluating a rare cause of adrenocorticotropic hormone-independent Cushing's syndrome in the transition period between adolescence and adulthood. CASE PRESENTATION: A sibling pair with familial isolated primary pigmented nodular adrenocortical disease is described...
2015: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/26264719/genetics-of-primary-bilateral-macronodular-adrenal-hyperplasia-a-model-for-early-diagnosis-of-cushing-s-syndrome
#10
REVIEW
Ludivine Drougat, Stéphanie Espiard, Jerôme Bertherat
Long-term consequences of cortisol excess are frequent despite appropriate treatment after cure of Cushing's syndrome. This might be due to diagnostic delay, often difficult to reduce in rare diseases. The identification of a genetic predisposing factor might help to improve early diagnosis by familial screening. Primary bilateral macronodular adrenal hyperplasia (PBMAH) is a rare cause of Cushing's syndrome. Hypercortisolism in PBMAH is most often diagnosed between the fifth and sixth decades of life. The bilateral nature of the adrenocortical tumors and the occurrence of rare clear familial forms suggest a genetic origin...
October 2015: European Journal of Endocrinology
https://www.readbyqxmd.com/read/26214113/germline-deletion-of-armc5-in-familial-primary-macronodular-adrenal-hyperplasia
#11
Sawako Suzuki, Ichiro Tatsuno, Emi Oohara, Akitoshi Nakayama, Eri Komai, Akina Shiga, Takashi Kono, Tomoko Takiguchi, Seiichiro Higuchi, Ikki Sakuma, Hidekazu Nagano, Naoko Hashimoto, Takafumi Mayama, Hisashi Koide, Hironobu Sasano, Yukio Nakatani, Takashi Imamoto, Tomohiko Ichikawa, Koutaro Yokote, Tomoaki Tanaka
OBJECTIVE: Primary macronodular adrenal hyperplasia (PMAH) is considered a predominantly sporadic disease, but familial forms are well recognized. Genetic studies revealed germline mutations in the armadillo repeat containing 5 gene (ARMC5) in the majority of PMAH cases. Furthermore, somatic ARMC5 mutations, as different types of second-hit mutations and loss of heterozygosity have been reported in each adrenal nodule in PMAH. Here, we describe the involvement of ARMC5 alteration in a familial case of PMAH...
October 2015: Endocrine Practice
https://www.readbyqxmd.com/read/26208471/genetics-of-cushing-s-disease-an-update
#12
REVIEW
L G Perez-Rivas, M Reincke
INTRODUCTION: Cushing's disease (CD) results from uncontrolled hypercortisolism induced by ACTH-secreting corticotroph adenomas; accordingly, patients diagnosed with CD usually present several comorbidities and an increased risk of mortality. Hypothesis-driven screenings have led to identification of rare alterations in a low number of patients, although the genetic basis underlying CD has remained unclear until recently. Using whole-exome sequencing, recurrent mutations have been reported in the gene coding for the ubiquitin-specific protease 8 (USP8), a protein with deubiquitinase (DUB) activity that modulates the lysosomal turnover of the EGF receptor (EGFR) and other membrane proteins...
January 2016: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/26020233/disruption-of-mir-29-leads-to-aberrant-differentiation-of-smooth-muscle-cells-selectively-associated-with-distal-lung-vasculature
#13
Leah Cushing, Stefan Costinean, Wei Xu, Zhihua Jiang, Lindsey Madden, Pingping Kuang, Jingshu Huang, Alexandra Weisman, Akiko Hata, Carlo M Croce, Jining Lü
Differentiation of lung vascular smooth muscle cells (vSMCs) is tightly regulated during development or in response to challenges in a vessel specific manner. Aberrant vSMCs specifically associated with distal pulmonary arteries have been implicated in the pathogenesis of respiratory diseases, such as pulmonary arterial hypertension (PAH), a progressive and fatal disease, with no effective treatment. Therefore, it is highly relevant to understand the underlying mechanisms of lung vSMC differentiation. miRNAs are known to play critical roles in vSMC maturation and function of systemic vessels; however, little is known regarding the role of miRNAs in lung vSMCs...
May 2015: PLoS Genetics
https://www.readbyqxmd.com/read/25960965/concurrent-medullary-papillary-and-follicular-thyroid-carcinomas-and-simultaneous-cushing-s-syndrome
#14
Haggi Mazeh, Amir Orlev, Ido Mizrahi, David J Gross, Herbert R Freund
BACKGROUND: Papillary thyroid carcinoma is the most common thyroid cancer (85%). Follicular thyroid carcinoma is the second most common type of thyroid cancer, accounting for up to 10% of all thyroid cancers. Medullary thyroid carcinoma accounts for only 5-8% of thyroid cancers. Concurrent medullary, follicular, and papillary carcinomas of the thyroid gland are extremely rare and reported scarcely. CASE REPORT: A 72-year-old male presented with nonspecific neck pain...
March 2015: European Thyroid Journal
https://www.readbyqxmd.com/read/25936508/computational-modeling-and-biological-validation-of-novel-non-steroidal-ligands-for-the-cholesterol-recognition-interaction-amino-acid-consensus-crac-motif-of-the-mitochondrial-translocator-protein-tspo
#15
Andrew S Midzak, Nagaraju Akula, Malena B Rone, Vassilios Papadopoulos
Mitochondria play a critical role in the physiological homeostasis of the cell, contributing to numerous cellular processes, including bioenergetics, metabolism and cell life and death. Owing to their keystone role, mitochondria have gained much attention as pharmacological targets. The outer mitochondrial integral membrane translocator protein (TSPO) has attracted a significant degree of pharmacological interest owing to its ability to bind a number of classes of drugs with high affinity and specificity. In addition to its well-characterized drug binding site, TSPO possess an additional high-affinity ligand binding site, originally identified for its ability to bind the lipid cholesterol, which was named the cholesterol recognition/interaction amino acid consensus (CRAC) motif...
September 2015: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/25929879/white-matter-alterations-in-the-brains-of-patients-with-active-remitted-and-cured-cushing-syndrome-a-dti-study
#16
P Pires, A Santos, Y Vives-Gilabert, S M Webb, A Sainz-Ruiz, E Resmini, I Crespo, M de Juan-Delago, B Gómez-Anson
BACKGROUND AND PURPOSE: Cushing syndrome appears after chronic exposure to elevated glucocorticoid levels. Cortisol excess may alter white matter microstructure. Our purpose was to study WM changes in patients with Cushing syndrome compared with controls by using DTI and the influence of hypercortisolism. MATERIALS AND METHODS: Thirty-five patients with Cushing syndrome and 35 healthy controls, matched for age, education, and sex, were analyzed through DTI (tract-based spatial statistics) for fractional anisotropy, mean diffusivity, axial diffusivity, and radial diffusivity (general linear model, family-wise error, and threshold-free cluster enhancement corrections, P < ...
June 2015: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/25700646/-rare-forms-of-hypertension-from-pheochromocytoma-to-vasculitis
#17
H Haller, F Limbourg, B M Schmidt, J Menne
Secondary hypertension affects only 5-10 % of hypertensive patients. Screening is expensive and time-consuming and should be performed only in patients for whom there is a high clinical suspicion of secondary hypertension. Clinical signs of secondary forms of hypertension are new-onset hypertension in patients without other risk factors (i.e., family history, obesity, etc.), sudden increase of blood pressure (BP) in a previously stable patient, increased BP in prepubertal children, resistant hypertension, and severe hypertension or hypertensive emergencies...
March 2015: Der Internist
https://www.readbyqxmd.com/read/25637899/-familial-partial-lipodystrophy-type-1-a-rare-or-underdiagnosed-syndrome
#18
Jimena Soutelo, Mariana Grüneisen, Clara Fritz, Laura Sordo, Yanina Powazniak, Rubén Lutfi
Familial partial lipodystrophy (FPL) type 1 is a syndrome characterized by loss of subcutaneous fat in arms and legs and an excess of body fat in face, neck, and torso. This rare syndrome is usually diagnosed when patients present cardiovascular complications or pancreatitis due to the severe metabolic abnormalities. Here we present the case of a 45 year old diabetic female without any pathological family history, a poor glycemic control (HbA1c 11.7%), hypertriglideridemia (3000 mg/dl), a body mass index (BMI) of 38, thin limbs, subcutaneous fat loss in gluteal area and ledge of fat above them, prominent veins in lower extremities, moon face, and acanthosis nigricans; as well as hypertension (150/100 mmHg) and subcutaneous folds measuring less than average were observed...
2015: Medicina
https://www.readbyqxmd.com/read/25581606/clinician-challenges-in-providing-health-care-for-a-morbidly-obese-family-member-a-bariatric-case-study
#19
Janice M Beitz
Morbid obesity is a chronic disease affecting millions of Americans. The disorder is likely to increase in prevalence because currently one third of the American population is obese. Many factors are associated with morbid obesity, including psychological (eg, depression), physiological (eg, hypothyroidism) mechanisms, sleep disorders (eg, sleep apnea), drug therapy (antidepressants, antidiabetic agents, steroids), and genetics. Increasing numbers of morbidly obese patients are requiring critical care, presenting major challenges to professional staff across the disciplines...
January 2015: Ostomy/wound Management
https://www.readbyqxmd.com/read/25501963/from-first-symptoms-to-final-diagnosis-of-cushing-s-disease-experiences-of-176-patients
#20
Ilonka Kreitschmann-Andermahr, Tsambika Psaras, Maria Tsiogka, Daniel Starz, Bernadette Kleist, Sonja Siegel, Monika Milian, Johannes Kohlmann, Christa Menzel, Dagmar Führer-Sakel, Jürgen Honegger, Ulrich Sure, Oliver Müller, Michael Buchfelder
OBJECTIVE: To obtain structured information on the diagnostic delay in patients with Cushing's disease (CD) from the patients perspective to provide leverage points for earlier diagnosis. DESIGN: The study includes 176 patients with ACTH-dependent CD who had received pituitary surgery completed a self-developed questionnaire on their symptomatology before the illness was diagnosed, the course and length of the diagnostic process, and the role of the involved health care professionals...
March 2015: European Journal of Endocrinology
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