Dorota Nieoczym, Marta Marszalek-Grabska, Radoslaw Szalak, Uday Kundap, Agnieszka A Kaczor, Tomasz M Wrobel, Nataliia Kosheva, Malgorzata Komar, Michal Abram, Camila V Esguerra, Eric Samarut, Mateusz Pieróg, Marcin Jakubiec, Krzysztof Kaminski, Wirginia Kukula-Koch, Kinga Gawel
Previously, we demonstrated that palmatine (PALM) - an isoquinoline alkaloid from Berberis sibrica radix, exerted antiseizure activity in the pentylenetetrazole (PTZ)-induced seizure assay in larval zebrafish. The aim of the present study was to more precisely characterize PALM as a potential anticonvulsant drug candidate. A range of zebrafish and mouse seizure/epilepsy models were applied in the investigation. Immunostaining analysis was conducted to assess the changes in mouse brains, while in silico molecular modelling was performed to determine potential targets for PALM...
February 5, 2024: Biomedicine & Pharmacotherapy