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https://www.readbyqxmd.com/read/28629694/interleukin-6-participation-in-pathology-of-ocular-diseases
#1
REVIEW
Forouhe Zahir-Jouzdani, Fatemeh Atyabi, Nazanin Mojtabavi
Interleukin-6 (IL-6) is a multifunctional cytokine that affects a variety of cells in the body such as osteoclasts, hepatocytes, endothelial cells, epithelial cells, white and red blood cells and etc. Elevated levels of IL-6 have been detected in many ocular diseases. Studies show that IL-6 has a major role in the pathology of glaucoma, CRVO, macular edema, ocular neovascularization, posterior capsule opacity formation, keratitis, dry eye disease, allergic eye disease, ocular autoimmune disease, corneal chemical burn, ocular inflammation and so on...
June 10, 2017: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/28606862/pathogenicity-profile-of-vibrio-parahaemolyticus-in-farmed-pacific-white-shrimp-penaeus-vannamei
#2
R Ananda Raja, R Sridhar, C Balachandran, A Palanisammi, S Ramesh, K Nagarajan
A pathobiological study was conducted using Vibrio parahaemolyticus (VP) strain isolated from vibriosis affected shrimp (Penaeus vannamei) farms in Kancheepuram and Thiruvallur districts of Tamil Nadu during August 2014 to February 2015. The isolate was identified based on the morphological, physiological, biochemical and molecular characters. LD50 value with intramuscular injection was determined as 2.6 × 10(4) cfu/shrimp and sequential pathology was studied giving 6.1 × 10(3) cfu/shrimp (LD25). Total plate count (TPC) and total Vibrio count (TVC) in water, pond sediment, haemolymph, muscle, HP and gut were found significantly (P < 0...
June 9, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28606808/sambulin-a-and-b-non-glycosidic-iridoids-from-sambucus-ebulus-exert-significant-in-vitro-anti-inflammatory-activity-in-lps-induced-raw-264-7-macrophages-via-inhibition-of-mapks-s-phosphorylation
#3
İrem Atay Balkan, Ayca Zeynep İlter Akülke, Yeşim Bağatur, Dilek Telci, Ahmet Ceyhan Gören, Hasan Kırmızıbekmez, Erdem Yesilada
ETHNOPHARMACOLOGICAL RELEVANCE: The leaves of Sambucus ebulus L. (Adoxaceae) are widely used in Turkish folk medicine particularly against inflammatory disorders. The fresh leaves after wilted over fire or the poultices prepared are directly applied externally to heal burns, edema, eczema, urticarial and abscess. Two iridoids were recently isolated (sambulin A, sambulin B) from the leaves of S. ebulus. AIM OF THE STUDY: This study aims to investigate the in vitro anti-inflammatory activities of these iridoids on LPS-induced RAW 264...
June 10, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28602595/topical-treatment-of-corneal-alkali-burns-with-gly-thymosin-%C3%AE-4-solutions-and-in-situ-hydrogels-via-inhibiting-corneal-neovascularization-and-improving-corneal-epidermal-recovery-in-experimental-rabbits
#4
Weili Zhang, Liya Nie, Lina Du, Wenyang Chen, Zhihong Wu, Yiguang Jin
AIM: Corneal alkali burns are a severe disease and commonly encountered in the emergent clinic. A rapid medical treatment for the burn is very important. Gly-thymosin β4 (Gly-Tβ4) is a biomimic derivative of natural thymosin β4. The aim of this study is to evaluate the corneal recovery effects of Gly-Tβ4 topical therapy on alkali burns in rabbit corneas. METHODS: Rabbit alkali burns were induced with NaOH-contained filter paper. Phosphate-buffered solutions at pH 7...
June 9, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28576238/acute-fluid-management-of-large-burns-pathophysiology-monitoring-and-resuscitation
#5
REVIEW
Justin Gillenwater, Warren Garner
This article reviews the pathophysiology of large burn injury and the extreme fluid shifts that occur in the hours and days after this event. The authors focus on acute fluid management, monitoring of hemodynamic status, and end points of resuscitation. Understanding the need and causes for fluid resuscitation after burn injury helps the clinician develop an effective plan to balance the competing goals of normalized tissue perfusion and limited tissue edema. Thoughtful, individualized treatment is the best answer and the most effective compromise...
July 2017: Clinics in Plastic Surgery
https://www.readbyqxmd.com/read/28540005/post-photorefractive-keratectomy-pain-and-corneal-sub-basal-nerve-density
#6
Masoumeh Mohebbi, Amin Rafat-Nejad, Seyed-Farzad Mohammadi, Kosar Asna-Ashari, Maryam Kasiri, Saeed Heidari-Keshel, Farshad Askarizadeh
PURPOSE: The perceived and reported pain of patients receiving photorefractive keratectomy (PRK) widely varies. We assessed the potential role of the subbasal nerve plexus density as a predictor of postoperative pain level. Consecutive patients scheduled to undergo PRK at the Refractive Surgery Clinic of Farabi Eye Hospital, Tehran, were approached. METHODS: Forty-nine myopic left eyes from 49 patients who consented to undergo scanning slit confocal microscopy assessments preoperatively were included...
April 2017: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/28535116/is-mannitol-the-treatment-of-choice-for-patients-with-ciguatera-fish-poisoning
#7
Michael E Mullins, Robert S Hoffman
CONTEXT: Ciguatera fish poisoning arises primarily from consumption of carnivorous reef fish caught in tropical and sub-tropical waters. Ciguatoxins, a class of tasteless, heat-stable, polycyclic toxins produced by dinoflagellates, accumulate through the food chain and concentrate in various carnivorous fish, such as groupers, barracudas, wrasses, amberjack, kingfishes, and eels. Characteristics of ciguatera fish poisoning include early nausea, vomiting, and diarrhea in the first one to two days post ingestion, followed by the appearance of sensory disturbances...
May 23, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28522185/orofacial-complex-regional-pain-syndrome-pathophysiologic-mechanisms-and-functional-mri
#8
Yeon-Hee Lee, Kyung Mi Lee, Hyug-Gi Kim, Soo-Kyung Kang, Q-Schick Auh, Jyung-Pyo Hong, Yang-Hyun Chun
Complex regional pain syndrome (CRPS) is one of the most challenging chronic pain conditions and is characterized by burning pain, allodynia, hyperalgesia, autonomic changes, trophic changes, edema, and functional loss involving mainly the extremities. Until recently, very few reports have been published concerning CRPS involving the orofacial area. We report on a 50-year-old female patient who presented with unbearable pain in all of her teeth and hypersensitivity of the facial skin. She also reported intractable pain in both extremities accompanied by temperature changes and orofacial pain that increased when the other pains were aggravated...
March 14, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/28513988/aquagenic-cutaneous-disorders
#9
REVIEW
Fang Wang, Yu-Kun Zhao, Ze-Yu Luo, Qian Gao, Wei Wu, Rashmi Sarkar, Di-Qing Luo
Aquagenic cutaneous disorders, which include aquagenic urticaria, aquagenic pruritus, and aquagenic acrokeratoderma, are a group of rare diseases characterized by skin lesions or discomfort induced by brief contact with water. Aquagenic urticaria is characterized by pruritic wheals that occur at the sites of water contact, either immediately or within minutes, and disappear within 30-60 min after water removal. Aquagenic pruritus presents with severe pruritus or a stinging, tingling, or burning sensation without any visible skin changes...
June 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28508472/fatal-ingestion-of-chlumsky-disinfectant-solution
#10
Petr Handlos, Matěj Uvíra, Klára Marecová, Marie Staňková, Margita Smatanová, Igor Dvořáček, Marek Joukal
A 32-year-old pregnant woman in the 25th week of pregnancy underwent oral glucose tolerance screening at the diabetologist's. Later that day, she was found dead in her apartment possibly poisoned with Chlumsky disinfectant solution (solutio phenoli camphorata). An autopsy revealed chemical burns in the digestive system. The lungs and the brain showed signs of severe edema. The blood of the woman and fetus was analyzed using gas chromatography with mass spectrometry and revealed phenol, its metabolites (phenyl glucuronide and phenyl sulfate) and camphor...
May 16, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28489215/negative-pressure-therapy-for-the-treatment-of-complex-wounds
#11
Renan Victor Kümpel Schmidt Lima, Pedro Soler Coltro, Jayme Adriano Farina
The objective of this study is to evaluate the effectiveness of negative pressure therapy (NPT) in the treatment of complex wounds, with emphasis on its mechanisms of action and main therapeutic indications. We searched the Pubmed / Medline database for articles published from 1997 to 2016, and selected the most relevant ones. The mechanisms of action of NPT involveboth physical effects, such as increased perfusion, control of edema and exudate, reduction of wound dimensions and bacterial clearance, and biological ones, such as the stimulation of granulation tissue formation, microdeformations and reduction of Inflammatory response...
January 2017: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/28480384/evaluation-of-effectiveness-in-a-novel-wound-healing-ointment-crocodile-oil-burn-ointment
#12
Hua-Liang Li, Yi-Tao Deng, Zi-Ran Zhang, Qi-Rui Fu, Ya-Hui Zheng, Xing-Mei Cao, Jing Nie, Li-Wen Fu, Li-Ping Chen, You-Xiong Xiong, Dong-Yan Shen, Qing-Xi Chen
BACKGROUND: Crocodile oil and its products are used as ointments for burns and scalds in traditional medicines. A new ointment formulation - crocodile oil burn ointment (COBO) was developed to provide more efficient wound healing activity. The purpose of the study was to evaluate the burn healing efficacy of this new formulation by employing deep second-degree burns in a Wistar rat model. The analgesic and anti-inflammatory activities of COBO were also studied to provide some evidences for its further use...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28471989/valproic-acid-treatment-inhibits-vasopermeability-and-improves-survival-in-rats-with-lethal-scald-injury
#13
Fu-Bo Tang, Yue-Long Dai, Guo-Yong Zhou, Wen-Hua Zhang, Hai-Bin Wang, Yan-Guang Li, Rui-Liu, Hong-Min Luo, Sen Hu
The aim of this study was to examine whether administration of valproic acid (VPA), a histone deacetylase inhibitor, inhibits proinflammatory mediators and ameliorate visceral vasopermeability both in a rat model of major burn, and also in rat cultured endothelial cells stimulated with permeability evoking mediators. SD rats were subjected to a 50% TBSA full-thickness scald injury, and treated with either saline or VPA (300 mg/kg) intraperitoneally. Pulmonary vascular endothelial growth factor (VEGF), myeloperoxidase (MPO), pulmonary microvascular permeability, water content, and acetylation of histone H3K9 of lungs were evaluated...
April 28, 2017: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/28385365/texas-bull-nettle-cnidoscolus-texanus-exposures-reported-to-texas-poison-centers
#14
Mathias B Forrester
OBJECTIVE: Texas bull nettle (Cnidoscolus texanus) is covered in bristly hairs similar to stinging nettle. Contact with the plant may result in intense dermal pain, burning, itching, cellulitis, and allergic reaction. This study characterizes C texanus exposures reported to a large state-wide poison center system. METHODS: Cases were C texanus exposures reported to Texas poison centers during 2000-2015. The distribution of cases was determined for patient demographics, exposure circumstances, and patient outcome...
April 3, 2017: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/28371204/a-randomized-single-blinded-trial-of-a-tripeptide-hexapeptide-healing-regimen-following-laser-resurfacing-of-the-face
#15
Monique J Vanaman Wilson, Joanna Bolton, Sabrina Guillen Fabi
BACKGROUND: A topical healing system containing a combination of active ingredients including a tripeptide and hexapeptide (TriHex Technology™) has been found to stimulate neoelastogenesis and neocollagenesis. OBJECTIVE: Evaluate the use of the tripeptide/hexapeptide topical system following fractionated CO2 laser resurfacing compared to a bland ointment and cream. PATIENTS/METHODS: In this single-blinded, randomized study, 15 female subjects aged 45-70 years underwent laser resurfacing of the face...
March 31, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28365493/hydrogel-containing-silibinin-loaded-pomegranate-oil-based-nanocapsules-exhibits-anti-inflammatory-effects-on-skin-damage-uvb-radiation-induced-in-mice
#16
Marila Crivellaro Lay Marchiori, Cristina Rigon, Camila Camponogara, Sara Marchesan Oliveira, Letícia Cruz
The present study shows the development of a topical formulation (hydrogel) containing silibinin-loaded pomegranate oil based nanocapsules suspension and its evaluation as an alternative for the treatment of cutaneous UVB radiation-induced damages. For this, an animal model of skin injury induced by UVB radiation was employed. Gellan gum was used as gel forming agent by its direct addition to nanocapsules suspension. The hydrogels showed adequate pH values (5.6-5.9) and a silibinin content close to the theoretical value (1mg/g)...
May 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28363296/postburn-upper-extremity-occupational-therapy
#17
REVIEW
Tiffany Williams, Tanya Berenz
Upper extremity burns can result in lifelong complications. A comprehensive occupational therapy program is imperative for restoration of arm function. Edema management, splinting, exercise, scar management, and activities of daily living are key treatment elements to achieve optimal postburn outcomes. Proper patient and family education are essential for therapeutic success. Burn recovery requires a commitment to therapeutic techniques that can progress a patient to their maximal independence.
May 2017: Hand Clinics
https://www.readbyqxmd.com/read/28327841/-assessment-of-local-and-systemic-inflammatory-parameters-of-peripheral-burn-in-an-animal-model
#18
Wilmary Torres, Liseth Mendoza, Hember Vicci, Antonio Eblen-Zajjur, María Navarro
To evaluate the edema volume and leukocyte, platelet, and fibrinogen count of peripheral burn in an animal model. The back left leg of Rattus norvegicus (experimental group) was placed in water at 60 °C for 60 seconds or at room temperature (control group). An analysis was carried out before and after the induced burn (at 4, 8, 12, and 24 h). The edema volume was determined by an orthogonal photo, the leukocyte and platelet counts were determined using automated equipment, and the fibrinogen count was determined using the gravimetric method...
October 2016: Revista Peruana de Medicina Experimental y Salud Pública
https://www.readbyqxmd.com/read/28319529/the-notch-signaling-system-is-involved-in-the-regulation-of-reparative-angiogenesis-in-the-zone-of-stasis
#19
Ozan Luay Abbas, Orhan Özatik, Yunus Kasm Terzi, Fikriye Yasemin Özatik, Rukiye Nar, Gamze Turna
The Notch pathway ligand Delta-like 4 (Dll4) functions as an antiangiogenic factor, inhibiting vascular endothelial growth factor (VEGF)-induced angiogenesis. This function is documented in tumor and embryonic vasculature. However, its implication in burn wounds remains unexplored. Our objective was to explore the involvement of the Notch in the healing of zone of stasis burns. We hypothesized that anti-Dll4 therapy would prevent progressive necrosis in the stasis zone by promoting angiogenesis. Burns were created in 21 rats using the comb burn model...
March 13, 2017: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/28316837/combination-of-navigated-macular-laser-photocoagulation-and-anti-vegf-therapy-precise-treatment-for-macular-edema-under-dry-retinal-conditions
#20
Ernest V Boiko, Dmitrii S Maltsev
Purpose. To compare the controllability of navigated macular laser photocoagulation (MLP) in dry versus edematous retina and validate that pretreatment diagnostic images can be used as basis for navigated MLP after the macular edema (ME) has been resolved. Materials and Methods. Group 1 was divided into subgroup 1 (dry retina MLP) and subgroup 2 (MLP in ME) for comparisons of laser-burn diameters. In group 2, the areas and locations of ME before an intravitreal injection of anti-VEGF (IVAV) were compared with those of recurrent ME...
2017: Journal of Ophthalmology
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