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https://www.readbyqxmd.com/read/28637126/ecological-momentary-assessment-for-rehabilitation-of-chronic-illness-and-disability
#1
Ashlee McKeon, Michael McCue, Elizabeth Skidmore, Michelle Schein, Jamie Kulzer
PURPOSE: The main objectives of this manuscript were to provide a theoretical perspective on naturalistic delivery in rehabilitation based upon a literature review and establish a rationale for using ecological momentary assessment (EMA) for naturalistic assessment for chronic illness and disability (CID) in rehabilitation. METHOD: Existing literature on EMA use across CID cohorts was gathered and analyzed to form a theoretical overview of implementation of this method in research...
February 7, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28633741/high-frequency-ultrasound-features-in-a-case-of-gouty-panniculitis
#2
P Maldonado Cid, C Rubio Flores, I Prats Caelles, V M Leis Dosil, F Alfageme Roldán, P Richi Alberti, C Santonja Garriga, R M Díaz Díaz
Gouty panniculitis is caused by the deposition of urate crystals in the subcutaneous tissue, accompanied by a lobular panniculitis. It presents as subcutaneous nodules, most commonly located on the lower extremities. Being an unusual clinical presentation of gout, the sonographic findings of gouty panniculitis have been scarcely described in the literature. Our report describes the ultrasound features we found in a case of gouty panniculitis and the usefulness of this technique for diagnosis and monitoring of this disease...
June 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28631796/isomerization-versus-dissociation-of-phenylalanylglycyltryptophan-radical-cations
#3
Xiaoyan Mu, Justin Kai-Chi Lau, Cheuk-Kuen Lai, K W Michael Siu, Alan C Hopkinson, Ivan K Chu
Four isomers of the radical cation of tripeptide phenylalanylglycyltryptophan, in which the initial location of the radical center is well defined, have been isolated and their collision-induced dissociation (CID) spectra examined. These ions, the π-centered [FGWπ˙](+), α-carbon- [FGα˙W](+), N-centered [FGWN˙](+) and ζ-carbon- [Fζ˙GW](+) radical cations, were generated via collision-induced dissociation (CID) of transition metal-ligand-peptide complexes, side chain fragmentation of a π-centered radical cation, homolytic cleavage of a labile nitrogen-nitrogen single bond, and laser induced dissociation of an iodinated peptide, respectively...
June 20, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28630811/development-of-a-branched-radio-frequency-ion-trap-for-electron-based-dissociation-and-related-applications
#4
Takashi Baba, J Larry Campbell, J C Yves Le Blanc, Paul R S Baker, James W Hager, Bruce A Thomson
Collision-induced dissociation (CID) is the most common tool for molecular analysis in mass spectrometry to date. However, there are difficulties associated with many applications because CID does not provide sufficient information to permit details of the molecular structures to be elucidated, including post-translational-modifications in proteomics, as well as isomer differentiation in metabolomics and lipidomics. To face these challenges, we are developing fast electron-based dissociation devices using a novel radio-frequency ion trap (i...
2017: Mass Spectrometry
https://www.readbyqxmd.com/read/28627771/clinical-experience-with-the-integrase-inhibitors-dolutegravir-and-elvitegravir-in-hiv-infected-patients-efficacy-safety-and-tolerance
#5
Purificación Cid-Silva, Josep María Llibre, Noelia Fernández-Bargiela, Luis Margusino-Framiñán, Vanesa Balboa-Barreiro, Berta Pernas-Souto, Isabel Martín-Herranz, Ángeles Castro-Iglesias, Eva Poveda-López
Two integrase inhibitors (INSTIs), Dolutegravir (DTG) and Elvitegravir/Cobicistat (EVG/COBI) have joined recently the pharmacotherapy arsenal against HIV. This study evaluated the efficacy and tolerability of these INSTIs in the last two years. A retrospective observational study in patients who started DTG or EVG/COBI from January 2015 to January 2017 at a reference hospital in Northwestern Spain was done. Epidemiological, clinical and immunovirological data were recorded. A statistical analysis was performed using SPSS software...
June 19, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28621436/development-of-a-cell-based-gene-therapy-approach-to-selectively-turn-off-bone-formation
#6
Pedro Alvarez-Urena, Banghe Zhu, Gabrielle Henslee, Corinne Sonnet, Eleanor Davis, Eva Sevick-Muraca, Alan Davis, Elizabeth Olmsted-Davis
Cell and gene therapy approaches are safer when they possess a system that enables the therapy to be rapidly halted. Human mesenchymal stem cells were transduced with an adenoviral vector containing the cDNA for bone morphogenetic protein 2 (AdBMP2) to induce bone formation. To make this method safer, a system to quickly kill these virally transduced cells was designed and evaluated. Cells were encapsulated inside poly(ethylene glycol) diacrylate (PEG-Da) hydrogels that are able to shield the cells from immunological destruction...
June 16, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28621374/linker-functionalisation-triggers-an-alternative-3d-topology-for-zn-isophthalate-4-4-bipyridine-frameworks
#7
Andreas Schneemann, Robin Rudolf, Sebastian Henke, Yukiko Takahashi, Hung Banh, Inke Hante, Christian Schneider, Shin-Ichiro Noro, Roland A Fischer
A series of four Zn(2+) metal-organic frameworks containing functionalised isophthalate linkers and 4,4'-bipyridine pillars have been prepared and characterised. Isophthalates which contain -OC3H2n+1 alkoxy side chains (with n = 1, 2 or 3) form frameworks with a 3D pillared-layer topology instead of the typical 2D layer topology of the renowned coordination polymers with an interdigitated structure (CIDs), which is found for shorter -OC2H5 side chains. The gas adsorption properties of the materials were analysed using N2, CO2 and O2 adsorption measurements at low temperatures...
June 16, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28616721/biomarkers-in-pancreatic-ductal-adenocarcinoma
#8
REVIEW
J Gallego, C López, R Pazo-Cid, F López-Ríos, A Carrato
Pancreatic ductal adenocarcinoma (PDAC) is currently the third most frequent form of malignancy. The role of biomarkers in the diagnostic and therapeutic strategy of cancer is constantly expanding. Translational research is already changing paradigms in tumours encompassing from early diagnosis to precision medicine in advanced disease. Nomenclature for molecular subtypes of tumours is gradually gaining acceptance and there are growing expectations it will further go from the bench to the bedside. However, the clinical relevance of biomarkers in PDAC is still far behind the relevance of biomarkers in other solid tumours...
June 14, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28612268/discordant-sleep-parameters-among-actigraphy-polysomnography-and-perceived-sleep-in-patients-with-sleep-disordered-breathing-in-comparison-with-patients-with-chronic-insomnia-disorder
#9
Su Jung Choi, Miri Kang, Min Je Sung, Eun Yeon Joo
PURPOSE: Although the clinical usefulness of actigraphy (ACT) in chronic insomnia disorder (CID) is extensively investigated, the evaluation on the utility of ACT in sleep-disordered breathing (SDB) is limited and the report of comparison with perceived sleep by patients and polysomnography (PSG) is scarce. METHODS: Thirty-six patients with SDB and 30 with CID underwent PSG and ACT, and they reported perceived sleep time and latency simultaneously. Sleep parameters (total sleep time [TST], sleep onset latency [SOL], sleep efficiency, and wakefulness after sleep onset [WASO]) were compared...
June 14, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28611434/linking-optical-and-molecular-signatures-of-dissolved-organic-matter-in-the-mediterranean-sea
#10
Alba María Martínez-Pérez, Mar Nieto-Cid, Helena Osterholz, Teresa S Catalá, Isabel Reche, Thorsten Dittmar, Xosé Antón Álvarez-Salgado
Dissolved organic matter (DOM) plays a key role in global biogeochemical cycles and experiences changes in molecular composition as it undergoes processing. In the semi-closed basins of the oligotrophic Mediterranean Sea, these gradual molecular modifications can be observed in close proximity. In order to extend the spatial resolution of information on DOM molecular composition available from ultrahigh resolution mass spectrometry in this area, we relate this data to optical (fluorescence and absorption spectroscopy) measurements...
June 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28609179/maternal-distress-and-the-development-of-hypertensive-disorders-of-pregnancy
#11
Idalia Garza-Veloz, Claudia Castruita-De la Rosa, Yolanda Ortiz-Castro, Virginia Flores-Morales, Maria E Castañeda-Lopez, Edith Cardenas-Vargas, Gloria P Hernandez-Delgadillo, Vicente Ortega-Cisneros, Martha Luevano, Iram P Rodriguez-Sanchez, Fabiola Trejo-Vazquez, Ivan Delgado-Enciso, Miguel A Cid-Baez, Perla M Trejo-Ortiz, Maria G Ramos-Del Hoyo, Margarita L Martinez-Fierro
Despite the implementation of programmes to improve maternal health, maternal and foetal mortality rates still remain high. The presence of maternal distress and its association with the development of pregnancy hypertensive disorders is not well established. The aim of this study was to evaluate the association between maternal distress and the development of hypertensive disorders in pregnancy in a prospective cohort of 321 Mexican women. Symptoms of maternal distressing were evaluated at week 20th of gestation using the General Health Questionnaire...
June 13, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28606962/endothelin-1-promotes-vascular-smooth-muscle-cell-migration-across-the-artery-wall-a-mechanism-contributing-to-vascular-remodelling-and-intimal-hyperplasia-in-giant-cell-arteritis
#12
Ester Planas-Rigol, Nekane Terrades-Garcia, Marc Corbera-Bellalta, Ester Lozano, Marco A Alba, Marta Segarra, Georgina Espígol-Frigolé, Sergio Prieto-González, José Hernández-Rodríguez, Sara Preciado, Rodolfo Lavilla, Maria C Cid
BACKGROUND: Giant-cell arteritis (GCA) is an inflammatory disease of large/medium-sized arteries, frequently involving the temporal arteries (TA). Inflammation-induced vascular remodelling leads to vaso-occlusive events. Circulating endothelin-1 (ET-1) is increased in patients with GCA with ischaemic complications suggesting a role for ET-1 in vascular occlusion beyond its vasoactive function. OBJECTIVE: To investigate whether ET-1 induces a migratory myofibroblastic phenotype in human TA-derived vascular smooth muscle cells (VSMC) leading to intimal hyperplasia and vascular occlusion in GCA...
June 12, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28605899/generation-and-characterization-of-gas-phase-doubly-charged-biradical-peptide-ions-m2-%C3%A2-%C3%A2
#13
Y L Elaine Wong, Xiangfeng Chen, Ri Wu, Y L Winnie Hung, Hoi Sze Yeung, T-W Dominic Chan
The gas-phase chemistry of peptide radical ions is attracting considerable interest in the fields of biology and mass spectrometry owing to its capability to provide sequence information of peptides and proteins. In this study, we observed that doubly charged peptide ions (M2+) can be produced from the collision-induced dissociation (CID) of Hg(II)-adducted peptide ions. The chemical nature, and thus the dissociation pathways of this hydrogen-deficient biradical M2+ species is intriguing. We investigated the generation and dissociation behavior of this M2+ species under electron-capture dissociation (ECD) and CID conditions...
June 13, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28602552/intensity-fading-maldi-tof-mass-spectrometry-and-functional-proteomics-assignments-to-identify-protease-inhibitors-in-marine-invertebrates
#14
Giovanni Covaleda, Sebastian A Trejo, Emir Salas-Sarduy, Maday Alonso Del Rivero, Maria Angeles Chavez, Francesc X Aviles
Proteases and their inhibitors have become molecules of increasing fundamental and applicative value. Here we report an integrated strategy to identify and analyze such inhibitors from Caribbean marine invertebrates extracts by a fast and sensitive functional proteomics-like approach. The strategy works in three steps: i) multiplexed enzymatic inhibition kinetic assays, ii) Intensity Fading MALDI-TOF MS to establish a link between inhibitory molecules and the related MALDI signal(s) detected in the extract(s), and iii) ISD-CID-T(3) MS fragmentation on the parent MALDI signals selected in the previous step, enabling the partial or total top-down sequencing of the molecules...
June 5, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28602137/immediate-and-short-term-effects-of-phototherapy-on-pain-muscle-activity-and-joint-mobility-in-women-with-temporomandibular-disorder-a-randomized-double-blind-placebo-controlled-clinical-trial
#15
Carolina Marciela Herpich, Ernesto Cesar Pinto Leal-Junior, Cid Andre Fidelis de Paula Gomes, Igor Phillip Dos Santos Gloria, Ana Paula Amaral, Maitê de Freitas de Rocha Souza Amaral, Fabiano Politti, Daniela Aparecida Biasotto-Gonzalez
OBJECTIVES: The aim of the present study was to evaluate the immediate and short-term effects of phototherapy on pain intensity, the pressure pain threshold (PPT), maximum vertical mandibular movement, and the electrical activity of the masseter and temporal muscles in women with temporomandibular disorder (TMD). METHODS: Sixty women were randomly allocated to four different groups and submitted to phototherapy with a combination of super-pulsed laser (905 nm), red (640 nm), and infrared (875 nm) light emitting diodes in the same equipment on the masseter (three points) and temporal (two points) muscles bilaterally in a single session...
June 11, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28601593/detection-of-over-100-selenium-metabolites-in-selenized-yeast-by-liquid-chromatography-electrospray-time-of-flight-mass-spectrometry
#16
Bienvenida Gilbert-López, Mihaly Dernovics, David Moreno-González, Antonio Molina-Díaz, Juan F García-Reyes
The characterization of the selenometabolome of Selenized(Se)-yeast, that is the fraction of water soluble low-molecular weight Se-metabolites produced in Se-yeast is of paramount interest to expand the knowledge on the composition of this food supplement. In this work, we have applied liquid chromatography electrospray time-of-flight mass spectrometry (LC-TOFMS) to search for Se-species from the low molecular weight range fraction of the selenized yeast used for food supplements. Prior to LC-TOFMS, sample treatment consisted of ultrasound assisted water extraction followed by size exclusion fractionation assisted with off-line inductively coupled plasma mass spectrometry detection of isotope (82)Se...
June 4, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28601411/miniaccess-heart-surgery-a-spanish-multicenter-registry
#17
Sergio Juan Cánovas López, Francisco Estevez Cid, Guillermo Reyes Copa, María Jesús López Gude, José María Melero Tejedor, Sara Badía Gamarra
No abstract text is available yet for this article.
June 7, 2017: Revista Española de Cardiología
https://www.readbyqxmd.com/read/28599168/impurity-profiling-of-liothyronine-sodium-by-means-of-reversed-phase-hplc-high-resolution-mass-spectrometry-on-line-h-d-exchange-and-uv-vis-absorption
#18
M Ruggenthaler, J Grass, W Schuh, C G Huber, R J Reischl
For the first time, a comprehensive investigation of the impurity profile of the synthetic thyroid API (active pharmaceutical ingredient) liothyronine sodium (LT3Na) was performed by using reversed phase HPLC and advanced structural elucidation techniques including high resolution tandem mass spectrometry (HRMS/MS) and on-line hydrogen-deuterium (H/D) exchange. Overall, 39 compounds were characterized and 25 of these related substances were previously unknown to literature. The impurity classification system recently developed for the closely related API levothyroxine sodium (LT4Na) could be applied to the newly characterized liothyronine sodium impurities resulting in a wholistic thyroid API impurity classification system...
May 30, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28597999/a-rapid-and-easy-protein-n-terminal-profiling-strategy-using-n-succinimidyloxycarbonylmethyl-tris-2-4-6-trimethoxyphenyl-phosphonium-bromide-tmpp-labeling-and-stagetip
#19
Yanchang Li, Zhiqiang Wang, Wenjing Zhou, Kun Zhang, Jie Ma, Feilin Wu, Jianguo Ji, Xuechuan Hong, Zixin Deng, Simin He, Ping Xu
Protein N-terminal profiling is crucial when characterizing biological functions and provides proteomic evidences for genome reannotations. However, most of the current N-terminal enrichment approaches involve multiple chemical derivatizations and chromatographic separation processes which are time consuming and can contribute to N-terminal peptide losses. In this study, a fast, one-step approach utilizing TMPP derivatization and StageTip separation was developed to enhance N-terminal peptide enrichment and analysis...
June 9, 2017: Proteomics
https://www.readbyqxmd.com/read/28597352/role-of-inflammatory-diseases-in-hypertension
#20
REVIEW
E Bartoloni, A Alunno, V Valentini, F Luccioli, E Valentini, G La Paglia, O Bistoni, Roberto Gerli
Chronic inflammatory diseases (CID) are characterized by an increased risk of cardiovascular (CV) morbidity and mortality. Several mechanisms, including early acceleration of subclinical atherosclerotic damage, inflammatory markers and immune system deregulation factors, have been demonstrated to strictly interplay for development and progression of atherosclerosis. Moreover, traditional CV risk factors are likely to explain at least some of the excess of CV risk in these patients. Among traditional CV risk factors, compelling evidence suggests a higher incidence and prevalence of hypertension in patients with CID in comparison to the general population...
June 9, 2017: High Blood Pressure & Cardiovascular Prevention: the Official Journal of the Italian Society of Hypertension
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