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https://www.readbyqxmd.com/read/28929601/conversion-of-benzoic-acid-into-phenol-in-an-itms-under-ci-ms-n-conditions-recognition-of-ortho-chlorobenzoyl-derivatives
#1
Michela Begala
Isomeric chlorobenzoyl cations (m/z 139), under collision induced experiments, fragment identically. Chlorobenzoyl cations can be efficiently converted into cholorophenol radical cations by the reaction with methanol in the ion trap analyser under CI-MS(n) conditions. The substitution of the carbonyl group with a hydroxyl moiety is able to induce an ortho effect, which is absent in the starting ortho-chlorobenzoyl cation. This transformation could be useful to recognize ortho-chlorinated benzoyl derivatives without the need of MS spectra comparison of the whole set of isomers...
September 19, 2017: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/28927786/discovery-of-highly-potent-selective-covalent-inhibitors-of-jak3
#2
James Kempson, Damaso Ovalle, Junqing Guo, Stephen T Wrobleski, Shuqun Lin, Steven H Spergel, James J-W Duan, Bin Jiang, Zhonghui Lu, Jagabandhu Das, Bingwei V Yang, John Hynes, Hong Wu, John Tokarski, John S Sack, Javed Khan, Gary Schieven, Yuval Blatt, Charu Chaudhry, Luisa M Salter-Cid, Aberra Fura, Joel C Barrish, Percy H Carter, William J Pitts
A useful and novel set of tool molecules have been identified which bind irreversibly to the JAK3 active site cysteine residue. The design was based on crystal structure information and a comparative study of several electrophilic warheads.
September 11, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28927692/prognostic-influence-of-tumor-stroma-on-breast-cancer-subtypes
#3
Sandra Cid, Noemi Eiro, Berta Fernández, Rosario Sánchez, Alejandro Andicoechea, Pablo Ignacio Fernández-Muñiz, Luis O González, Francisco J Vizoso
INTRODUCTION: The objective of the present work was to evaluate the impact of the phenotype of both intratumoral mononuclear inflammatory cells (MICs) and cancer-associated fibroblast (CAFs), assessed as to their expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) on prognosis in different breast cancer subtypes. MATERIALS AND METHODS: A total of 247 tumors of patients with primary ductal invasive breast cancer were categorized into 1 of 4 major subtypes, using the 3 standard immunohistochemical markers (estrogen receptor [ER], progesterone receptor [PR], and human epidermal growth factor receptor/Neu 2 [HER2] receptor status)...
August 19, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28927610/structure-and-immunomodulatory-activity-of-a-sulfated-agarose-with-pyruvate-and-xylose-substitutes-from-polysiphonia-senticulosa-harvey
#4
Xiaoliang Zhao, Guangling Jiao, Yi Yang, Miaomiao Li, Qinying Li, Xiaojiang Wang, Chao Cai, Guoyun Li, Jiejie Hao, Guangli Yu
A charged and size uniform polysaccharide PS2 was prepared from red seaweed Polysiphonia senticulosa Harvey. Based on nuclear magnetic resonance (NMR), fourier transform infrared (FTIR) spectroscopy, and electrospray ionization collision-induced-dissociation mass spectrometry (ESI-CID-MS(n)) analysis, PS2 was determined to be a novel 6-O-sulfated agarose which was mainly composed of a repeating unit of alternating (1→3)-linked 6-sulfated-β-d-galactose and (1→4)-linked 3,6-anhydro-α-l-galactose in association with small amount of pyruvate substituted on galactose residues and xylose (Xyl) branched at C2 position of 3,6-anhydro-galactose...
November 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28926788/study-of-the-degradation-process-of-ofloxacin-with-free-chlorine-by-using-esi-lcmsms-kinetic-study-by-products-formation-pathways-and-fragmentation-mechanisms
#5
Montaha H Yassine, Ahmad Rifai, Maha Hoteit, Patrick Mazellier, Mohammad Al Iskandarani
This study was conducted to gain a better understanding of the fate of fluoroquinolone antibacterial ofloxacin (OFX) which is the free available chlorine (FAC) in order to determine its effect during water chlorination process. The Direct reactions of FAC with OFX were quite rapid. A half-life of 7.7 s was measured under pseudo-first order conditions in the presence of an excess of total chlorine ([FAC]0 = 13 μM and [OFX]0 = 0.55 μM at pH 7.2 and 20 °C in buffered reagent water. Free chlorine reactions rates were of first-order type in both substrate and oxidant with specific second-order rate constants of 6...
September 4, 2017: Chemosphere
https://www.readbyqxmd.com/read/28924832/influence-of-linkage-stereochemistry-and-protecting-groups-on-glycosidic-bond-stability-of-sodium-cationized-glycosyl-phosphates
#6
Y Zhu, Zhihua Yang, M T Rodgers
Energy-resolved collision-induced dissociation (ER-CID) experiments of sodium cationized glycosyl phosphate complexes, [GP x +Na](+), are performed to elucidate the effects of linkage stereochemistry (α versus β), the geometry of the leaving groups (1,2-cis versus 1,2-trans), and protecting groups (cyclic versus non-cyclic) on the stability of the glycosyl phosphate linkage via survival yield analyses. A four parameter logistic dynamic fitting model is used to determine CID50% values, which correspond to the level of rf excitation required to produce 50% dissociation of the precursor ion complexes...
September 18, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/28923662/selecting-of-a-cytochrome-p450cam-sesam-library-with-3-chloroindole-and-endosulfan-identification-of-mutants-that-dehalogenate-3-chloroindole
#7
Shaima Kammoonah, Brinda Prasad, Priyadarshini Balaraman, Hemanshu Mundhada, Ulrich Schwaneberg, Erika Plettner
Cytochrome P450cam (a camphor hydroxylase) from the soil bacterium Pseudomonas putida shows potential importance in environmental applications such as the degradation of chlorinated organic pollutants. Seven P450cam mutants generated from Sequence Saturation Mutagenesis (SeSaM) and isolated by selection on minimal media with either 3-chloroindole or the insecticide endosulfan were studied for their ability to oxidize of 3-chloroindole to isatin. The wild-type enzyme did not accept 3-chloroindole as a substrate...
September 15, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28921966/tool-for-rapid-analysis-of-glycopeptide-by-permethylation-trap-via-one-pot-site-mapping-and-glycan-analysis
#8
Asif Shajahan, Nitin Tatyaso Supekar, Christian Heiss, Mayumi Ishihara, Parastoo Azadi
To overcome the challenges in the analysis of protein glycosylation, we have developed a comprehensive and universal tool through permethylation of glycopeptides and their tandem mass spectrometric analysis. This method has the potential to simplify glycoprotein analysis by integrating glycan sequencing and glycopeptide analysis in a single experiment. Moreover, glycans with unique glycosidic linkages, particularly from prokaryotes, which are resistant to enzymatic or chemical release, could also be detected and analyzed by this methodology...
September 18, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28921955/characterization-of-site-specific-glycosylation-in-influenza-a-virus-hemagglutinin-produced-by-spodoptera-frugiperda-insect-cell-line
#9
Yanjun Liu, Shiaw-Lin Wu, Kerry Routenberg Love, William S Hancock
Influenza hemagglutinin is a surface glycoprotein related to virus invasion and host immune system response. Understanding site specific glycosylation of hemagglutinin will increase our knowledge about virus evolution and can improve the design and quality of vaccines. In our study, we used glycoproteomic analysis based on multienzyme digestion followed by LC tandem MS analysis to determine the glycosylation of Influenza hemagglutinin (H1/A/California/04/2009) using the following steps: PNGaseF treatment combined with trypsin or pepsin digestion were used to determine the glycosites and glycan occupancy...
September 18, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28918762/standard-comparison-of-local-mental-health-care-systems-in-eight-european-countries
#10
M R Gutiérrez-Colosía, L Salvador-Carulla, J A Salinas-Pérez, C R García-Alonso, J Cid, D Salazzari, I Montagni, F Tedeschi, G Cetrano, K Chevreul, J Kalseth, G Hagmair, C Straßmayr, A L Park, R Sfectu, T Ala-Nikkola, J L González-Caballero, L Rabbi, B Kalseth, F Amaddeo
AIMS: There is a need of more quantitative standardised data to compare local Mental Health Systems (MHSs) across international jurisdictions. Problems related to terminological variability and commensurability in the evaluation of services hamper like-with-like comparisons and hinder the development of work in this area. This study was aimed to provide standard assessment and comparison of MHS in selected local areas in Europe, contributing to a better understanding of MHS and related allocation of resources at local level and to lessen the scarcity in standard service comparison in Europe...
September 18, 2017: Epidemiology and Psychiatric Sciences
https://www.readbyqxmd.com/read/28917436/comparison-of-the-loop-technique-with-incision-and-drainage-for-soft-tissue-abscesses-a-systematic-review-and-meta-analysis
#11
REVIEW
Michael Gottlieb, Gary D Peksa
INTRODUCTION: Skin and soft tissue infections are a common presentation to the emergency department. Traditional management of abscesses involves a linear incision through the center of the abscess with packing placed. The loop drainage technique (LDT) is an alternate approach that may reduce pain and scarring, as well as decrease the number of follow up visits needed. This systematic review and meta-analysis aimed to compare the efficacy of the LDT with conventional incision and drainage (CID) in the treatment of soft tissue abscesses...
September 10, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28916309/uptake-of-cholesterol-by-tetrahymena-thermophila-is-mainly-due-to-phagocytosis
#12
María Eugenia Elguero, María Luz Sanchez Granel, María Guadalupe Montes, Nicolás G Cid, Nicolás O Favale, Clara B Nudel, Alejandro D Nusblat
No abstract text is available yet for this article.
September 12, 2017: Revista Argentina de Microbiología
https://www.readbyqxmd.com/read/28916186/clinical-immunological-and-genetic-spectrum-of-696-patients-with-combined-immunode%C3%AF-ciency
#13
Hassan Abolhassani, Janet Chou, Wayne Bainter, Craig Platt, Mahmood Tavassoli, Toba Momen, Marzieh Tavakol, Mohammad Hossein Eslamian, Mohammad Gharagozlou, Masoud Movahedi, Mohsen Ghadami, Amir Ali Hamidieh, Gholamreza Azizi, Reza Yazdani, Mohsen Afarideh, Alireza Ghajar, Arash Havaei, Zahra Chavoushzadeh, Seyed Alireza Mahdaviani, Taher Cheraghi, Nasrin Behniafard, Reza Amin, Soheila Aleyasin, Reza Faridhosseini, Farahzad Jabbari-Azad, Mohammamd Nabavi, Mohammad Hassan Bemanian, Saba Arshi, Rasol Molatefi, Roya Sherkat, Mahboubeh Mansouri, Mehrnaz Mesdaghi, Delara Babaie, Iraj Mohammadzadeh, Javad Ghaffari, Alireza Shafiei, Najmeddin Kalantari, Hamid Ahanchian, Maryam Khoshkhui, Habib Soheili, Abbas Dabbaghzadeh, Afshin Shirkani, Rasoul Nasiri Kalmarzi, Seyed Hamidreza Mortazavi, Javad Tafaroji, Abbas Khalili, Javad Mohammadi, Babak Negahdari, Mohammad-Taghi Joghataei, Basel K Al-Ramadi, Capucine Picard, Nima Parvaneh, Nima Rezaei, Talal Chatila, Michel J Massaad, Sevgi Keles, Lennart Hammarström, Raif S Geha, Asghar Aghamohammadi
BACKGROUND: Combined immunodeficiencies (CIDs) are diseases of defective adaptive immunity with diverse clinical phenotypes. Although CIDs are more prevalent in the Middle East than Western countries, the resources for genetic diagnosis are limited. OBJECTIVES: This study aims to characterize the categories of CID patients in Iran clinically and genetically. METHODS: Clinical and laboratory data were obtained from 696 patients with CIDs. Patients were subdivided into those with syndromic (344 patients) and non-syndromic CIDs (352 patients)...
September 12, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28910683/the-coordination-of-shoulder-girdle-muscles-during-repetitive-arm-movements-at-either-slow-or-fast-pace-among-women-with-or-without-neck-shoulder-pain
#14
Leticia Bergamin Januario, Ana Beatriz Oliveira, Marina Machado Cid, Pascal Madeleine, Afshin Samani
PURPOSE: The aim of this study was to evaluate the coordination of the shoulder girdle muscles among subjects with or without neck-shoulder pain performing repetitive arm movement at either a slow or fast pace. METHODS: Thirty female adults were allocated to one of two groups-healthy controls or cases with neck-shoulder pain. Surface electromyography (sEMG) signals from the clavicular, acromial, middle and lower trapezius portions and the serratus anterior muscles were recorded during a task performed for 20min at a slow pace and 20min at a fast pace...
September 11, 2017: Human Movement Science
https://www.readbyqxmd.com/read/28902151/apetx4-a-novel-sea-anemone-toxin-and-a-modulator-of-the-cancer-relevant-potassium-channel-kv10-1
#15
Lien Moreels, Steve Peigneur, Diogo T Galan, Edwin De Pauw, Lászlo Béress, Etienne Waelkens, Luis A Pardo, Loïc Quinton, Jan Tytgat
The human ether-à-go-go channel (hEag1 or KV10.1) is a cancer-relevant voltage-gated potassium channel that is overexpressed in a majority of human tumors. Peptides that are able to selectively inhibit this channel can be lead compounds in the search for new anticancer drugs. Here, we report the activity-guided purification and electrophysiological characterization of a novel KV10.1 inhibitor from the sea anemone Anthopleura elegantissima. Purified sea anemone fractions were screened for inhibitory activity on KV10...
September 13, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28900710/coupling-matrix-assisted-ionization-with-high-resolution-mass-spectrometry-and-electron-transfer-dissociation-to-characterize-intact-proteins-and-post-translational-modifications
#16
Bingming Chen, Christopher B Lietz, Lingjun Li
Matrix-assisted ionization (MAI) is a recently developed ionization technique that produces multiply charged ions on either electrospray ionization (ESI) or matrix-assisted laser desorption/ionization (MALDI) platform without the need of high voltage or laser ablation. In this study, MAI has been coupled to a high resolution accurate mass (HRAM) hybrid instrument, the Orbitrap Elite mass spectrometer, with electron transfer dissociation (ETD) module for fast peptide and intact protein characterization. The softness of MAI process preserves labile post-translational modifications (PTM) and allows fragmentation and localization by ETD...
September 12, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28899907/a-novel-function-of-cxcl10-in-mediating-monocyte-production-of-proinflammatory-cytokines
#17
Qihong Zhao, Taeg Kim, Jian Pang, Wendy Sun, Xiaoxia Yang, Jinhong Wang, Yunling Song, Hongwei Zhang, Huadong Sun, Vangipuram Rangan, Shrikant Deshpande, Huaping Tang, Mary Ellen Cvijic, Richard Westhouse, Timothy Olah, Jenny Xie, Mary Struthers, Luisa Salter-Cid
IFN-γ-inducible protein 10 (CXCL10), a chemokine that is abundantly secreted in response to inflammatory stimuli, has been implicated in the pathogenesis of multiple inflammatory diseases, such as inflammatory bowel disease. Whereas CXCL10 is traditionally recognized for recruiting pathogenic T cells to inflamed sites, its nonchemotactic role during inflammation remains poorly defined. In this report, we identified a novel function of CXCL10 in the regulation of the inflammatory potential of human monocytes to produce cytokines...
September 12, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28899412/the-effect-of-information-about-the-benefits-and-harms-of-mammography-on-women-s-decision-making-study-protocol-for-a-randomized-controlled-trial
#18
Misericòrdia Carles, Montserrat Martínez-Alonso, Anna Pons, Maria José Pérez-Lacasta, Lilisbeth Perestelo-Pérez, Maria Sala, Carmen Vidal, Montse Garcia, Ana Toledo-Chávarri, Núria Codern, Maria Feijoo-Cid, Anabel Romero, Roger Pla, Jorge Soler-González, Xavier Castells, Montserrat Rué
BACKGROUND: The decision to participate or not in breast cancer screening is complex due to the trade-off between the expected benefit of breast cancer mortality reduction and the major harm of overdiagnosis. It seems ethically necessary to inform women so that they can actively participate in decision-making and make an informed choice based on their values and preferences. The objective of this study is to assess the effects of receiving information about the benefits and harms of screening on decision-making, in women approaching the age of invitation to mammography screening...
September 12, 2017: Trials
https://www.readbyqxmd.com/read/28892241/seasonal-variations-in-the-profile-of-main-phospholipids-in-mytilus-galloprovincialis-mussels-a-study-by-hydrophilic-interaction-liquid-chromatography-electrospray-ionization-fourier-transform-mass-spectrometry
#19
Laura Facchini, Ilario Losito, Tommaso R I Cataldi, Francesco Palmisano
A systematic characterization of phosphatidylcholines (PC) and phosphatidylethanolamines (PE) in mussels of sp. Mytilus galloprovincialis was performed by high efficiency Hydrophilic Interaction LIquid Chromatography (HILIC) combined with ElectroSpray Ionization (ESI) and Fourier-Transform Mass Spectrometry (FTMS), based on a quadrupole-Orbitrap hybrid spectrometer. FTMS/MS experiments under high-collisional energy dissociation (HCD) conditions, complemented by low energy collisionally induced dissociation (CID) MS(n) (n = 2,3) experiments, performed in a linear ion trap mass spectrometer, were exploited for structural elucidation purposes...
September 11, 2017: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/28889248/towards-discovery-and-targeted-peptide-biomarker-detection-using-nanoesi-tims-tof-ms
#20
Alyssa Garabedian, Paolo Benigni, Cesar E Ramirez, Erin S Baker, Tao Liu, Richard D Smith, Francisco Fernandez-Lima
In the present work, the potential of trapped ion mobility spectrometry coupled to TOF mass spectrometry (TIMS-TOF MS) for discovery and targeted monitoring of peptide biomarkers from human-in-mouse xenograft tumor tissue was evaluated. In particular, a TIMS-MS workflow was developed for the detection and quantification of peptide biomarkers using internal heavy analogs, taking advantage of the high mobility resolution (R = 150-250) prior to mass analysis. Five peptide biomarkers were separated, identified, and quantified using offline nanoESI-TIMS-CID-TOF MS; the results were in good agreement with measurements using a traditional LC-ESI-MS/MS proteomics workflow...
September 9, 2017: Journal of the American Society for Mass Spectrometry
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