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https://www.readbyqxmd.com/read/29147712/a-biocompatible-betaine-functionalized-polycation-for-coacervation
#1
Mintai P Hwang, Xiaochu Ding, Jin Gao, Abhinav P Acharya, Steven R Little, Yadong Wang
The aqueous nature of complex coacervates provides a biologically-relevant context for various therapeutic applications. In this sense, biological applications demand a corresponding level of biocompatibility from the polyelectrolytes that participate in complex coacervation. Continued development with naturally-occurring polyelectrolytes such as heparin and chitosan underscore such aims. Herein, we design a synthetic polycation, in which betaine is conjugated to a biodegradable polyester backbone. Betaine is a naturally-occurring methylated amino acid that is ubiquitously present in human plasma...
November 17, 2017: Soft Matter
https://www.readbyqxmd.com/read/29137283/c1q-tumor-necrosis-factor-related-protein-3-protects-macrophages-against-lps-induced-lipid-accumulation-inflammation-and-phenotype-transition-via-ppar%C3%AE-and-tlr4-mediated-pathways
#2
Jiale Lin, Qi Liu, Hui Zhang, Xingtao Huang, Ruoxi Zhang, Shuyuan Chen, Xuedong Wang, Bo Yu, Jingbo Hou
Macrophage inflammation and foam cell formation are critical events during the initiation and development of atherosclerosis (AS). C1q/tumor necrosis factor-related protein-3 (CTRP3) is a novel adipokine with anti-inflammatory and cardioprotection properties; however, little is known regarding the influence of CTRP3 on AS. As macrophages play a key role in AS, this study investigated the effects of CTRP3 on macrophage lipid metabolism, inflammatory reactions, and phenotype transition, as well as underlying mechanisms, to reveal the relationship between CTRP3 and AS...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29136761/galangin-inhibits-the-cell-progression-and-induces-cell-apoptosis-through-activating-pten-and-caspase-3-pathways-in-retinoblastoma
#3
Wen-Wei Zou, Su-Ping Xu
Retinoblastoma is reported as a rare cancer that occurs during childhood. Although several treatments are available for retinoblastoma, there is a need for alternative new treatment modalities for retinoblastoma with better safety and efficacy profile. Galangin (3,5,7-trihydroxyflavone), is a flavonoid compound, which is found in high concentration in lesser galangal. Galangin has been reported to have various bioactivities, including anti-inflammation, anti-oxidative stress and anti-cancer through various pathways...
November 6, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29130461/intracellular-coassembly-boosts-the-anti-inflammation-capacity-of-dexamethasone
#4
Wei Tang, Jingbo Yang, Zhibin Zhao, Zhexiong Lian, Gaolin Liang
Dexamethasone (Dex) is one of the essential medicines used to treat inflammation diseases but an overdose of Dex leads to severe adverse effects. The development of a new strategy to boost the anti-inflammation efficacy of Dex is, therefore, important but remains challenging. Herein, by employing an enzyme-instructed self-assembly system, we developed an intracellular coassembly strategy to boost the anti-inflammation efficacy of Dex. Under the catalysis of alkaline phosphatase (ALP), the hydrogelator precursor Nap-Phe-Phe-Tyr(H2PO3)-OH (1p) self-assembled to form Gel 1 but dexamethasone sodium phosphate (Dp) only yielded Dex precipitates...
November 13, 2017: Nanoscale
https://www.readbyqxmd.com/read/29128494/the-shrimp-hormone-receptor-acts-as-an-anti-apoptosis-and-anti-inflammatory-factor-in-innate-immunity
#5
Zhi Wang, Baozhen Sun, Fei Zhu
Previously, we found that the expression of several genes, including HR, varied in Drosophila melanogaster after white spot syndrome virus (WSSV) infection. In this present study, we further investigated the role of HR in Kuruma shrimp, Marsupenaeus japonicus and determined its anti-apoptosis and anti-inflammation role in the innate immune system. We successfully identified a partial sequence (866 bp in length) of the M. japonicus hormone receptor ligand binding domain (mjHR_LBD/mjHR). The 5' end of mjHR was successfully obtained; the open reading frame (ORF) ran from 33 to 701 bp, and encoded a protein containing 222 amino acids...
November 8, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29127058/trace-anti-inflammatory-%C3%AE-carboline-alkaloid-identified-in-arenaria-kansuensis-by-two-dimensional-chromatography-coupled-with-unielut-c18aex-based-solid-phase-extraction-re-enrichment-technology
#6
Yulei Cui, Na Shen, Shuo Wang, Lijuan Mei, Zenggen Liu, Jun Dang, Yanduo Tao
Traditional Chinese medicine is important for discovery of drug precursors. However, information about trace chemical composition of them is very limited due to the lack of appropriate enrichment and chromatographic purification methods In our work, A. kansuensis was taken as an example, a novel two-dimensional reversed-phase/hydrophilic interaction liquid chromatography coupled with UniElut C18AEX solid-phase extraction re-enrichment method based on anti-inflammatory bioactivity-guided assay was developed for gathering and purifying trace β-carboline alkaloids with high purity from the ethyl acetate extract of A...
October 31, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29121826/treatment-of-traumatic-brain-injury-with-vepoloxamer-purified-poloxamer-188
#7
Yanlu Zhang, Michael Chopp, Martin Emanuele, Li Zhang, Zheng Gang Zhang, Mei Lu, Talan Zhang, Asim Mahmood, Ye Xiong
Vepoloxamer is an amphipathic polymer that has shown potent hemorrheologic, cytoprotective, and anti-inflammatory effects in both preclinical and clinical studies. This study was designed to investigate the therapeutic effects of vepoloxamer on sensorimotor and cognitive functional recovery in rats after traumatic brain injury (TBI) induced by controlled cortical impact. Young adult male Wistar rats were randomly divided into the following groups: 1) Sham; 2) Saline; or 3) Vepoloxamer. Vepoloxamer (300 mg/kg) or saline was intravenously administered over 60 min via intravenous infusion into tail veins starting at 2 h post injury...
November 9, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29119920/polyphenols-inflammation
#8
Midori Natsume
BACKGROUND: Polyphenols widely distributed in plants, fruits and vegetables have received considerable attention on account of their physiological functions, including their antioxidant and anti-inflammatory properties. Some antioxidant components of cacao liquor prepared from fermented and roasted cacao beans, which is a major ingredient of cocoa and chocolate products, have been characterized as flavan-3-ols and procyanidin oligomers Methods: This review focuses on a specific group of (-)-epicatechins and their oligomers, the procyanidins, in cacao products...
November 8, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29119332/therapeutic-effect-of-vinorine-on-sciatic-nerve-injured-rat
#9
Dongdong Guo, Xingang Lu, Xiaoli Xu, Haixin Gou, Zhiqian Wang, Yi Cao, Xingjing Luo
Vinorine is a monoterpenoid indole alkaloid, a type of natural alkaloids. Growing reports exhibited the numerous pharmacology activities of vinorine such as anti-inflammation, anti-bacterial and anti-tumor. In this study, the effect of vinorine injection (7.5, 15 and 30 mg/kg) on motor function, sensation and nerve regeneration in sciatic nerve crush injury rat was investigated. The results of behavioral analysis, electrophysiological analysis and muscle histological analysis suggested that vinorine promoted the motor function recovery after sciatic nerve injury...
November 8, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/29118012/effects-and-mechanisms-of-caffeine-to-improve-immunologic-and-metabolic-abnormalities-in-diet-induced-obese-rats
#10
Chih-Wei Liu, Hung-Cheng Tsai, Chia-Chang Huang, Chang-Youh Tsai, Yen-Bo Su, Ming-Wei Lin, Kuei Chuan Lee, Yun-Cheng Hsieh, Tzu-Hao Li, Shiang-Fen Huang, Ying-Ying Yang, Ming-Chih Hou, Han-Chieh Lin, Fa-Yauh Lee, Shou-Dong Lee
In obesity, there are no effective therapies for parallel immune and metabolic abnormalities including systemic/tissue insulin-resistance/inflammation, adiposity and hepatic steatosis. Caffeine has anti-inflammation, anti-hepatic steatosis and anti-insulin-resistance effects. In this study, we evaluated the effects and molecular mechanisms of 6-week of caffeine treatment (HFD-caf) on immunologic and metabolic abnormalities of high-fat diet (HFD)-induced obese rats. In comparison with HFD-V rats, in HFD-caf rats the suppressed circulating immune cell inflammatory [TNFα, MCP-1, IL-6, intercellular adhesion molecule1 (ICAM-1) and nitrite] profiles were accompanied by decreased liver, white adipose tissue (WAT) and muscle' macrophages and its intracellular cytokines levels...
November 7, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29114910/n-acetylcysteine-attenuates-the-cuprizone-induced-behavioral-changes-and-oligodendrocyte-loss-in-male-c57bl-7-mice-via-its-anti-inflammation-actions
#11
Lin Zhang, Shuqin Xu, Qingjun Huang, Haiyun Xu
Previous animal studies have linked white matter damage to certain schizophrenia-like behaviors in cuprizone (CPZ)-exposed mouse. Mitochondrial dysfunction, oxidative stress, neuroinflammation, and oligodendrocyte loss coexist in the brain of such mice. The aim of this study was to examine effects of the antioxidant N-acetylcysteine (NAC) on CPZ-induced behavioral changes and concurrent oligodendrocyte loss, oxidative stress, and neuroinflammation in these animals. Male C57BL/6 mice were given intraperitoneal saline or NAC at doses of 100, 200, and 400 mg/kg/day for 2 weeks; animals were fed a CPZ-containing diet (0...
November 8, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/29113798/fucoxanthin-attenuates-fatty-acid-induced-lipid-accumulation-in-fl83b-hepatocytes-through-regulated-sirt1-ampk-signaling-pathway
#12
Yi-Hsien Chang, Ya-Ling Chen, Wen-Chung Huang, Chian-Jiun Liou
The fucoxanthin, isolated from brown algae, was reported to have multiple biological functions to anti-inflammation, anti-tumor, and ameliorated obesity in mice. In this study we investigated whether fucoxanthin could inhibit lipids accumulation in FL83B hepatocytes. FL83B cells were induced as fatty liver cell model by 0.5 mM oleic acid for 48 h, and treated with various concentration of fucoxanthin for 24 h. The results demonstrated that fucoxanthin significantly suppressed lipid accumulation and decreased lipid peroxidation in hepatocytes...
November 4, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29113143/sevoflurane-postconditioning-induced-anti-inflammation-via-inhibition-of-the-toll-like-receptor-4-nuclear-factor-kappa-b-pathway-contributes-to-neuroprotection-against-transient-global-cerebral-ischemia-in-rats
#13
Jung-Won Hwang, Young-Tae Jeon, Young-Jin Lim, Hee-Pyoung Park
The anti-inflammatory actions of sevoflurane postconditioning are suggested as an important mechanism of sevoflurane postconditioning-induced neuroprotection against cerebral ischemia. Here, we determined whether the anti-inflammatory effects of sevoflurane postconditioning were mediated via inhibition of the toll-like receptor (TLR)-4/nuclear factor kappa B (NF-κB) pathway after global transient cerebral ischemia in rats. Forty-five rats were randomly assigned to five groups as follows: (1) control (10 min of ischemia, n = 10); (2) sevoflurane postconditioning (two periods of sevoflurane inhalation after ischemia for 10 min with a wash period of 10 min, n = 10); (3) resatorvid (intraperitoneal injection of a selective TLR-4 antagonist (3 mg/kg) 30 min before ischemia, n = 10); (4) sevoflurane postconditioning plus resatorvid (n = 10), and sham (n = 5)...
November 6, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29112935/histone-deacetylase-6-inhibitor-acy-1215-protects-against-experimental-acute-liver-failure-by-regulating-the-tlr4-mapk-nf-%C3%AE%C2%BAb-pathway
#14
Wen-Bin Zhang, Hai-Yue Zhang, Fang-Zhou Jiao, Lu-Wen Wang, Hong Zhang, Zuo-Jiong Gong
Histone deacetylase 6 (HDAC6) is considered a new target for anticancer, anti-inflammatory, and neurodegenerative treatment. ACY-1215 is a selective histone deacetylase 6 inhibitor, and it has been recognized as a potential anticancer and anti-inflammation drug. The aim of our study was to investigate whether ACY-1215 has protective effects on acute liver failure (ALF) in mice and explore its potential mechanism. Male C57/BL6 mice were divided into normal, model, and ACY-1215 groups. ACY-1215 (25mg/kg) and same amounts of saline were given to mice...
November 4, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29112932/anti-atherosclerotic-effect-of-longxuetongluo-capsule-in-high-cholesterol-diet-induced-atherosclerosis-model-rats
#15
J M Zhou, H M Wang, Y Z Lv, Z Z Wang, W Xiao
Chinese dragon's blood, the red resin of Dracaena cochinchinensis, one of the famous traditional medicines, has been used to promote blood circulation, disperse blood stasis, stop bleeding, relieve pain and muscle regeneration for thousands of years. The aims of this study were to evaluate the anti-atherosclerotic effect of Longxuetongluo Capsule (LTC), which made by total phenolic compounds of Chinese dragon's blood, in high cholesterol diet (HCD)-induced atherosclerosis model rats and explore the possible mechanism...
November 4, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29102463/novel-ureidopropanamide-based-n-formyl-peptide-receptor-2-fpr2-agonists-with-potential-application-for-central-nervous-system-disorders-characterized-by-neuroinflammation
#16
Madia Letizia Stama, Joanna Ślusarczyk, Enza Lacivita, Liliya N Kirpotina, Igor A Schepetkin, Katarzyna Chamera, Chiara Riganti, Roberto Perrone, Mark T Quinn, Agnieszka Basta-Kaim, Marcello Leopoldo
Formyl peptide receptor2 (FPR2) is a G-protein coupled receptor that plays critical roles in inflammatory reactions. FPR2-specific interaction can be possibly used to facilitate the resolution of pathological inflammatory responses by enhancing endogenous anti-inflammation systems. Starting from our lead agonist 5, we designed new ureidopropanamides derivatives able to activate FPR2 in transfected cells and human neutrophils. The new FPR2 agonists showed good stability towards oxidative metabolism in vitro...
December 1, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29101873/cathelicidin-wa-polarizes-e-coli-k88-induced-m1-macrophage-to-m2-like-macrophage-in-raw264-7-cells
#17
Shan Chen, Zeqing Lu, Fengqin Wang, Yizhen Wang
Immune cells - macrophages induced by E. coli K88 will lead to a pro-inflammatory response, which is important in host defense. Cathelicidin-WA (CWA) is an efficient antimicrobial peptide (AMP) and can exert immunomodulatory properties. Many studies have demonstrated that AMP can modulate cellular subsets but whether CWA can regulate macrophage polarization by transferring E. coli K88-induced M1 macrophage towards M2 one that of anti-inflammation remains unclear. In this study, E. coli K88 increased the expression of pro-inflammatory cytokines interleukin-6, interleukin-1β, tumor necrosis factor-α and chemokine CCL3 in RAW264...
November 1, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29100291/hinokitiol-up-regulates-mir-494-3p-to-suppress-bmi1-expression-and-inhibits-self-renewal-of-breast-cancer-stem-progenitor-cells
#18
Shih-Ming Chen, Bing-Yen Wang, Che-Hsin Lee, Hsueh-Te Lee, Jung-Jung Li, Guan-Ci Hong, Yu-Chieh Hung, Peng-Ju Chien, Che-Ying Chang, Li-Sung Hsu, Wen-Wei Chang
Hinokitiol (β-thujaplicin) is a tropolone-related compound that has anti-microbe, anti-inflammation, and anti-tumor effects. Cancer stem/progenitor cells (CSCs) are a subpopulation of cancer cells with tumor initiation, chemoresistant, and metastatic properties and have been considered the important therapeutic target in future cancer therapy. Previous studies reported that hinokitiol exhibits an anti-cancer activity against murine tumor cells through the induction of autophagy. The current research revealed that hinokitiol suppressed the self-renewal capabilities of human breast CSCs (BCSCs) and inhibited the expression of BMI1 at protein level without suppressing its mRNA...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29098837/-pharmacokinetics-of-mercury-after-oral-administration-of-cinnabaris-and-fufang-niuhuang-xiaoyan-capsule-in-rats
#19
Xiao-Ni Song, Yu-Ting Lu, Dan-Yi Yang, Sheng Wang, Tai-Jun Hang, Min Song
Fufang Niuhuang Xiaoyan capsule was a classical compound prescription with the efficacy of heat-clearing, detoxification, sedation and anti-inflammation, with cinnabaris as one of its active ingredients. The study focuses on the pharmacokinetics of mercury in rats after oral administration of cinnabaris and Fufang Niuhuang Xiaoyan capsule, in order to explore the effect of combined traditional Chinese medicines on mercury metabolism. In this study, the method of nitric-perchloric acid digestion system coupled with cold atomic-atomic fluorescence spectroscopy (CV-AFS) was adopted to accurately determine mercury in whole blood of rats...
July 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29098818/-advanced-progress-of-main-pharmacology-activities-of-triptolide
#20
REVIEW
Jin Cui, Xiao Chen, Jia-Can Su
Triptolide is an active component in traditional Chinese medicine Tripterygium wilfordii. Currently, triptolide has been used to treat various diseases, including lupus, cancer, rheumatoid arthritis and nephritic syndrome. Its main pharmacology efficacies include anti-inflammation, anti-tumor, and immunity suppression. Recent studies have also demonstrated triptolide's protective effect on cardiovascular diseases and osteoporosis. This paper summarizes the pharmacological efficacy of triptolide based on the advance in studies of triptolide...
July 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
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