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https://www.readbyqxmd.com/read/27865732/prevention-of-heartmate-ii-pump-thrombosis-through-clinical-management-the-prevent-multi-center-study
#1
Simon Maltais, Ahmet Kilic, Sriram Nathan, Mary Keebler, Sitaramesh Emani, John Ransom, Jason N Katz, Brett Sheridan, Andreas Brieke, Gregory Egnaczyk, John W Entwistle, Robert Adamson, John Stulak, Nir Uriel, John B O'Connell, David J Farrar, Kartik S Sundareswaran, Igor Gregoric
BACKGROUND: Recommended structured clinical practices including implant technique, anti-coagulation strategy, and pump speed management (PREVENT [PREVENtion of HeartMate II Pump Thrombosis Through Clinical Management] recommendations) were developed to address risk of early (<3 months) pump thrombosis (PT) risk with HeartMate II (HMII; St. Jude Medical, Inc. [Thoratec Corporation], Pleasanton, CA). We prospectively assessed the HMII PT rate in the current era when participating centers adhered to the PREVENT recommendations...
November 16, 2016: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/27861427/quality-of-life-and-mid-term-survival-of-patients-bridged-with-extracorporeal-membrane-oxygenation-to-left-ventricular-assist-device
#2
Shinya Unai, Kentaro Yamane, Daizo Tanaka, Gary Cook, Hitoshi Hirose, Nicholas C Cavarocchi, John W C Entwistle
Insertion of a left ventricular assist device (LVAD) improves survival and quality of life (QOL) in patients with class IV heart failure failing medical management. However, QOL and survival of patients bridged to LVAD with extracorporeal membrane oxygenation (ECMO) is unknown. Between July 2008 and June 2014, 213 patients underwent insertion of HeartMate II LVAD at 2 VAD centers without a bridge with a temporary VAD. ECMO was used as a bridge prior to LVAD insertion in 22 INTERMACS 1 patients (ECMO-VAD group)...
November 15, 2016: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/27834198/intermacs-interagency-registry-for-mechanically-assisted-circulatory-support-profiling-identifies-ambulatory-patients-at-high-risk-on-medical-therapy-after-hospitalizations-for-heart-failure
#3
Garrick C Stewart, Michelle M Kittleson, Parag C Patel, Jennifer A Cowger, Chetan B Patel, Maria M Mountis, Frances L Johnson, Maya E Guglin, J Eduardo Rame, Jeffrey J Teuteberg, Lynne W Stevenson
BACKGROUND: INTERMACS (Interagency Registry for Mechanically Assisted Circulatory Support) profiles provide important prognostic information for patients with advanced heart failure (HF) receiving mechanical support. The value of INTERMACS profiling has not been shown for patients followed on medical therapy for advanced HF at centers that also offer mechanical circulatory support. METHODS AND RESULTS: This prospective, observational study enrolled 166 patients with chronic New York Heart Association class III-IV HF, ejection fraction ≤30%, and ≥1 HF hospitalization in the previous year, excluding patients listed for transplant or receiving chronic intravenous inotropic therapy...
November 2016: Circulation. Heart Failure
https://www.readbyqxmd.com/read/27816511/does-small-size-matter-with-continuous%C3%A2-flow-devices-analysis-of-the-intermacs-database-of-adults-with-bsa%C3%A2-%C3%A2-1-5-m-2
#4
Farhan Zafar, Chet R Villa, David L Morales, Elizabeth D Blume, David N Rosenthal, James K Kirklin, Angela Lorts
OBJECTIVES: This study investigated how small patient size affects clinical outcomes in patients implanted with a continuous flow left ventricular assist device (CFLVAD). BACKGROUND: The development of smaller CFLVADs has allowed ventricular assist device (VAD) use in anatomically smaller patients; however, limited outcome data exist regarding CFLVAD use in patients with a body surface area (BSA) ≤1.5 m(2). METHODS: All CFLVAD patients entered in the Interagency Registry for Mechanically Assisted Circulatory Support registry April 2008 to September 2013 and with BSA data were included...
October 27, 2016: JACC. Heart Failure
https://www.readbyqxmd.com/read/27816510/learning-from-our-predictions-the-heartmate-risk-score-in-intermacs
#5
EDITORIAL
Garrick C Stewart
No abstract text is available yet for this article.
December 2016: JACC. Heart Failure
https://www.readbyqxmd.com/read/27793972/mid-term-mechanical-circulatory-support-comparison-of-single-centre-data-with-the-euromacs-registry
#6
Katarzyna Zuk, Brigitta Gahl, Martina Susac, Juliane Vierecke, Theo M M H de By, Stephan Windecker, Lars Englberger, Thierry Carrel, Roland Hetzer, Jan Gummert, Paul Mohacsi
OBJECTIVES: Mechanical circulatory support (MCS) is an established therapy for end-stage heart failure. The EUROMACS registry was created to promote research in patients with MCS and became a committee of the European Association for Cardio-Thoracic Surgery (EACTS) in 2014. Since 1 January 2011, increasing numbers of European centres implanting durable MCS have reported their patient data to EUROMACS. The aim of this study is to compare, as an example of internal quality control, data from a single centre (Bern) with those from the EUROMACS database with respect to mortality rates and preoperative patient characteristics and to describe complications in Bern...
October 27, 2016: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/27793517/a-multi-institutional-outcome-analysis-of-patients-undergoing-left-ventricular-assist-device-implantation-stratified-by-sex-and-race
#7
Justin van Meeteren, Simon Maltais, Shannon M Dunlay, Nicholas A Haglund, Mary Beth Davis, Jennifer Cowger, Palak Shah, Keith D Aaronson, Francis D Pagani, John M Stulak
BACKGROUND: Earlier studies have demonstrated disparities in patients undergoing left ventricular assist device (LVAD) implantation when stratified according to sex and race. Because very few data exist from large investigations, we reviewed data from the registry of the Mechanical Circulatory Support Research Network. METHODS: Between May 2004 and September 2014, 734 patients underwent primary LVAD implantation at our institutions. Median age at implant was 57 (range 18 to 82) years and there were 577 males (80%)...
September 7, 2016: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/27788150/calciotropic-and-phosphaturic-hormones-in-end-stage-heart-failure-patients-supported-by-a-left-ventricular-assist-device
#8
Armin Zittermann, Jana B Ernst, Stefan Pilz, Jens Dreier, Joachim Kuhn, Cornelius Knabbe, Jan F Gummert, Michiel Morshuis, Hendrik Milting
BACKGROUND: Calcium and phosphate are central for myocardial contractility and energy metabolism, and low levels of the calciotropic hormone 1,25-dihydroxyvitamin D (1,25(OH)2D), as well as high levels of the phosphaturic hormone fibroblast growth factor (FGF)-23, are independently associated with poor clinical outcome in heart failure (HF) patients. We therefore aimed to investigate the postoperative time course of the aforementioned hormones in HF patients supported with a left-ventricular assist device (LVAD) implant...
2016: PloS One
https://www.readbyqxmd.com/read/27773454/sex-differences-and-in-hospital-outcomes-in-patients-undergoing-mechanical-circulatory-support-implantation
#9
Colleen K McIlvennan, JoAnn Lindenfeld, David P Kao
BACKGROUND: Mechanical circulatory support (MCS) is a widely available management strategy. No studies have described sex differences in both extracorporeal and durable MCS. We analyzed sex-related differences of in-hospital outcomes for extracorporeal and durable MCS using administrative hospital data. METHODS: In total, 134.5 million hospital records between 1994 and 2012 were screened for placement of MCS using procedure codes of the International Classification of Diseases-9, Clinical Modification...
August 20, 2016: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/27749316/comparing-the-effectiveness-of-an-axial-and-a-centrifugal-left-ventricular-assist-device-in-ventricular-unloading
#10
David M Turer, Kelly L Koch, Todd M Koelling, Audrey H Wu, Francis D Pagani, Jonathan W Haft
Centrifugal (CFG) and axial flow (AX) left ventricular assist devices have different hydrodynamic properties that may impact the effectiveness of left ventricular unloading. We sought to determine whether patients implanted with the HeartWare HVAD (CFG) and HeartMate II (AX) had a similar degree of hemodynamic support by comparing parameters measured using echocardiography and right heart catheterization. Using our prospectively collected database, we identified 268 patients implanted with the AX and 93 with the CFG...
November 2016: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/27687196/cardiac-recovery-during-long-term-left%C3%A2-ventricular-assist-device-support
#11
Omar Wever-Pinzon, Stavros G Drakos, Stephen H McKellar, Benjamin D Horne, William T Caine, Abdallah G Kfoury, Dean Y Li, James C Fang, Josef Stehlik, Craig H Selzman
BACKGROUND: The number of centers with left ventricular assist device (LVAD) research programs focused on cardiac recovery is very small. Therefore, this phenomenon has been reported in real-world multi-center registries as a rare event. OBJECTIVES: This study evaluated the incidence of cardiac recovery with an a priori LVAD implantation strategy of bridge-to-recovery (BTR) and constructed a recovery predictive model. METHODS: The study included LVAD recipients registered in the Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS)...
October 4, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27658844/device-strategies-for-patients-in-intermacs-profiles-1-and-2-cardiogenic-shock-double-bridge-with-extracorporeal-membrane-oxygenation-and-initial-implant-of-more-durable-devices
#12
Richard Cheng, Danny Ramzy, Babak Azarbal, Francisco A Arabia, Fardad Esmailian, Lawrence S Czer, Jon A Kobashigawa, Jaime D Moriguchi
For Interagency Registry for Mechanically Assisted Circulatory Support profiles 1 and 2 cardiogenic shock patients initially placed on extracorporeal membrane oxygenation (ECMO), whether crossover to more durable devices is associated with increased survival, and its optimal timing, are not established. Profiles 1 and 2 patients placed on mechanical support were prospectively registered. Survival and successful hospital discharge were compared between patients placed on ECMO only, ECMO with early crossover, and ECMO with delayed crossover...
September 23, 2016: Artificial Organs
https://www.readbyqxmd.com/read/27648979/predictors-of-in-hospital-mortality-among-cardiogenic-shock-patients-prognostic-and-therapeutic-implications
#13
Xin Li, Iago Sousa-Casasnovas, Carolina Devesa, Miriam Juárez, Francisco Fernández-Avilés, Manuel Martínez-Sellés
BACKGROUND: Cardiogenic shock (CS) has a poor prognosis. The heterogeneity in the mortality through different subgroups suggests that some factors can be useful to perform risk stratification and guide management. We aimed to find predictors of in-hospital mortality in these patients. METHODS: We analyzed all cases of cardiogenic shock due to medical conditions admitted in our intensive acute cardiovascular care unity from November 2010 till November 2015. Clinical, biochemical and hemodynamic variables were registered, as was the Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) profile at 24h of CS diagnosis...
December 1, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27614939/the-heartmate-risk-score-identifies-patients-with-similar-mortality-risk-across%C3%A2-all-intermacs-profiles-in-a%C3%A2-large%C3%A2-multicenter-analysis
#14
Luigi Adamo, Yuanyuan Tang, Michael E Nassif, Eric Novak, Philip G Jones, Shane LaRue, John A Spertus, Douglas L Mann
OBJECTIVES: This study sought to assess the performance of the HeartMate Risk Score (HMRS) in a large multicenter cohort, with a focus on its performance as a function of disease severity. BACKGROUND: The HMRS has been proposed as a simple tool for risk stratification of LVAD recipients, but subsequent studies have challenged its validity. METHODS: We performed a retrospective, longitudinal, comparative study using the INTERMACS (Interagency Registry for Mechanically Assisted Circulatory Support) database...
December 2016: JACC. Heart Failure
https://www.readbyqxmd.com/read/27556150/outcomes-of-adult-patients-with-small-body-size-supported-with-a-continuous-flow-left-ventricular-assist-device
#15
Sangjin Lee, Jason N Katz, Ulrich P Jorde, Nader Moazami, Ranjit John, Kartik S Sundareswaran, David J Farrar, O H Frazier
There is insufficient data on patients with small body size to determine if this should be considered a risk factor for continuous-flow left ventricular assist device (CF-LVAD) support. We sought to evaluate survival outcomes, adverse events, and functional status of CF-LVAD patients with body surface area (BSA) <1.5 m in a large national registry. Adults with BSA < 1.5 m (n = 128) implanted with a HeartMate II (HMII)-LVAD from the Interagency Registry for Mechanically Assisted Circulatory Support registry from April 2008 to December 2012 formed this cohort...
November 2016: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/27507111/frequency-of-poor-outcome-death-or-poor-quality-of-life-after-left-ventricular-assist-device-for-destination-therapy-results-from-the-intermacs-registry
#16
Suzanne V Arnold, Philip G Jones, Larry A Allen, David J Cohen, Timothy J Fendler, Jonathan E Holtz, Sanjeev Aggarwal, John A Spertus
BACKGROUND: A left ventricular assist device (LVAD) improves survival and quality of life for many, but not all, patients with end-stage heart failure who are ineligible for transplantation. We sought to evaluate the frequency of poor outcomes using a novel composite measure that integrates quality of life with mortality. METHODS AND RESULTS: Within the INTERMACS (Interagency Registry for Mechanically Assisted Circulatory Support) national registry, poor outcome was defined as death or an average Kansas City Cardiomyopathy Questionnaire <45 during the year after LVAD (persistently limiting heart failure symptoms and poor quality of life)...
August 2016: Circulation. Heart Failure
https://www.readbyqxmd.com/read/27496489/comparison-of-mechanical-circulatory-support-by-the-use-of-pulsatile-left-ventricular-assist-devices-polvad-mev-and-continuous-flow-heart-ware-and-heart-mate-ii-in-a-single-center-experience
#17
P Nadziakiewicz, J Pacholewicz, M Zakliczynski, T Niklewski, J Borkowski, T Hrapkowicz, M Zembala
BACKGROUND: Mechanical circulatory support is increasingly used in patients with heart failure as a bridge to transplant or recovery. Results of use the Polish POLVAD MEV pulsatile circulatory support system and its comparison with novel devices never was done. We compared the course of patients with left ventricular circulatory support (left ventricular assist device [LVAD]) supported by POLVAD MEV or continuous flow devices Heart Mate II (HM II) and Heart Ware (HW) in single-center cohort...
June 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27435529/evaluation-of-von-willebrand-factor-with-a-fully-magnetically-levitated-centrifugal-continuous-flow-left-ventricular-assist-device-in-advanced-heart-failure
#18
Ivan Netuka, Tomáš Kvasnička, Jan Kvasnička, Ingrid Hrachovinová, Peter Ivák, František Mareček, Jana Bílková, Ivana Malíková, Michaela Jančová, Jiří Malý, Poornima Sood, Kartik S Sundareswaran, Jean M Connors, Mandeep R Mehra
BACKGROUND: Contemporary continuous-flow left ventricular assist devices (CF-LVADs) are associated with degradation of von Willebrand factor (vWF) high-molecular-weight multimers (HMWMs), a critical factor supporting platelet function. We hypothesized that the HeartMate 3 fully magnetically levitated LVAD, designed to reduce circulatory shear stress, favorably influences these hemostatic parameters. METHODS: Fifteen consecutive HeartMate 3 LVAD patients were compared with 11 consecutive HeartMate II controls...
July 2016: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/27402861/myocardial-recovery-in-patients-receiving-contemporary-left-ventricular-assist-devices-results-from-the-interagency-registry-for-mechanically-assisted-circulatory-support-intermacs
#19
Veli K Topkara, A Reshad Garan, Barry Fine, Amandine F Godier-Furnémont, Alexander Breskin, Barbara Cagliostro, Melana Yuzefpolskaya, Koji Takeda, Hiroo Takayama, Donna M Mancini, Yoshifumi Naka, Paolo C Colombo
BACKGROUND: Time course and predictors of myocardial recovery on contemporary left ventricular assist device support are poorly defined because of limited number of recovery patients at any implanting center. This study sought to investigate myocardial recovery using multicenter data from the Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS). METHODS AND RESULTS: Thirteen thousand four hundred fifty-four adult patients were studied. Device explant rates for myocardial recovery were 0...
July 2016: Circulation. Heart Failure
https://www.readbyqxmd.com/read/27373233/japanese-multicenter-outcomes-with-the-heartmate-ii-left-ventricular-assist-device-in-patients-with-small-body-surface-area
#20
Minoru Ono, Yoshiki Sawa, Takeshi Nakatani, Ryuji Tominaga, Yoshiro Matsui, Kenji Yamazaki, Yoshikatsu Saiki, Hiroshi Niinami, Goro Matsumiya, Hirokuni Arai
BACKGROUND: The HeartMate II (HMII) continuous-flow LVAD was approved for Japanese health insurance coverage in April 2013 as a bridge to transplantation (BTT). We report on post-approval Japanese multicenter outcomes, and a comparison between patients with low and high body surface area (BSA). METHODS AND RESULTS: HMII LVAD was implanted in 104 consecutive patients at 15 Japanese centers between April 2013 and July 2014. Perioperative data were submitted to the Japanese Registry for Mechanically Assisted Circulatory Support...
August 25, 2016: Circulation Journal: Official Journal of the Japanese Circulation Society
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