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https://www.readbyqxmd.com/read/28214136/japanese-guidelines-for-occupational-allergic-diseases-2017
#1
REVIEW
Kunio Dobashi, Kazuo Akiyama, Atsushi Usami, Hiroo Yokozeki, Zenro Ikezawa, Naomi Tsurikisawa, Yoichi Nakamura, Kazuhiro Sato, Jiro Okumura, Kaoru Takayama
In 2013, a guideline for occupational allergic diseases was published for the first time in Japan. Occupational allergic diseases are likely to worsen or become intractable as a result of continuous exposure to high concentrations of causative antigens, and are socioeconomically important diseases with which the patients might sometimes lose jobs due to work interruptions. Guidelines for occupational allergic diseases have been published in many countries. This guideline consists of six chapters about occupational asthma, occupational allergic rhinitis, occupational skin diseases, hypersensitivity pneumonitis and occupational anaphylaxis shock, and legal aspects of these diseases...
February 14, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28207628/earlier-endpoints-are-required-for-hemorrhagic-shock-trials-among-severely-injured-patients
#2
Erin E Fox, John B Holcomb, Charles E Wade, Eileen M Bulger, Barbara C Tilley
BACKGROUND: Choosing the appropriate endpoint for a trauma hemorrhage control trial can determine the likelihood of its success. Recent Phase 3 trials and observational studies have used 24-h and/or 30-day all-cause mortality as the primary endpoint and some have not used exception from informed consent (EFIC), resulting in multiple failed trials. Five recent high-quality prospective studies among 4,064 hemorrhaging trauma patients provide new evidence to support earlier primary endpoints...
February 15, 2017: Shock
https://www.readbyqxmd.com/read/28197050/invasive-candidiasis-in-severe-acute-pancreatitis-experience-from-a-tertiary-care-teaching-hospital
#3
Arvind Kumar Baronia, Afzal Azim, Armin Ahmed, Mohan Gurjar, Rungmei S K Marak, Reema Yadav, Preeti Sharma
BACKGROUND: Invasive candidiasis (IC) is associated with increased morbidity in severe acute pancreatitis (SAP). There is limited information regarding the predisposing factors, Candida species distribution and in vitro susceptibility. METHODOLOGY: Current data have been derived from a larger prospective nonintervention study conducted on 200 critically ill patients which was done to study the antifungal prescription practices, collect epidemiological data, and perform an external validation of risk prediction models for IC under senior research associateship program of Council of Scientific and Industrial Research New Delhi...
January 2017: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28196415/hierarchical-assembly-of-tough-bioelastomeric-egg-capsules-is-mediated-by-a-bundling-protein
#4
Jun Jie Loke, Akshita Kumar, Shawn Hoon, Chandra S Verma, Ali Miserez
Marine snail egg capsules are shock-absorbing bio-elastomers made from precursor "egg case proteins" (ECPs) that initially lack long-range order. During capsule formation, these proteins self-assemble into coiled-coil filaments that subsequently align into microscopic layers, a multi-scale process which is crucial to the capsules' shock-absorbing properties. In this study, we show that the self-assembly of ECPs into their functional capsule material is mediated by a bundling protein that facilitates the aggregation of coiled-coil building blocks and their gelation into a pre-final capsule prior to final stabilization...
February 14, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28195947/alpha-msh-induces-vasodilatation-and-exerts-cardioprotection-via-the-heme-oxygenase-pathway-in-rat-hearts
#5
Miklos Vecsernyes, Miklos Szokol, Mariann Bombicz, Daniel Priksz, Rudolf Gesztelyi, Gabor Aron Fulop, Balazs Varga, Bela Juhasz, David Haines, Arpad Tosaki
Alpha-melanocyte-stimulating hormone (α-MSH) is a protein with known capacity for protection against cardiovascular ischemia-reperfusion (I/R) injury. The present investigation evaluates the capacity of α-MSH to mitigate I/R effects in an isolated working rat heart model and determine the dependency of these alterations on the activity of heme oxygenase-1 (HO-1, hsp-32), a heat shock protein that functions as a major antioxidant defense molecule. Healthy male Sprague-Dawley rats were used for all experiments...
February 13, 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/28193292/the-effect-of-elevated-temperatures-on-the-life-history-and-insecticide-resistance-phenotype-of-the-major-malaria-vector-anopheles-arabiensis-diptera-culicidae
#6
Shüné V Oliver, Basil D Brooke
BACKGROUND: Temperature plays a crucial role in the life history of insects. Recent climate change research has highlighted the importance of elevated temperature on malaria vector distribution. This study aims to examine the role of elevated temperatures on epidemiologically important life-history traits in the major malaria vector, Anopheles arabiensis. Specifically, the differential effects of temperature on insecticide-resistant and susceptible strains were examined. METHODS: Two laboratory strains of A...
February 14, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28192256/response-of-gut-health-and-microbiota-to-sulfide-exposure-in-pacific-white-shrimp-litopenaeus-vannamei
#7
Yantong Suo, Erchao Li, Tongyu Li, Yongyi Jia, Jian G Qin, Zhimin Gu, Liqiao Chen
Sulfide is a natural and widely distributed toxicant. It can be commonly found on the interface between water and sediment in the aquatic environment. The Pacific white shrimp Litopenaeus vannamei starts life in the benthic zone soon after the mysis stage, an early stage of post larvae. Therefore, L. vannamei is inevitably affected by exposure to sulfide released from pond sediment. This study explored the toxicant effect of different concentrations of sulfide on the intestinal health and microbiota of Pacific white shrimp by monitoring the change of expression of inflammatory, immune related cytokines, and the structure of the intestinal microbiota...
February 10, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28186140/activated-niacin-receptor-hca2-inhibits-chemoattractant-mediated-macrophage-migration-via-g%C3%AE-%C3%AE-pkc-erk1-2-pathway-and-heterologous-receptor-desensitization
#8
Ying Shi, Xiangru Lai, Lingyan Ye, Keqiang Chen, Zheng Cao, Wanghua Gong, Lili Jin, Chunyan Wang, Mingyong Liu, Yuan Liao, Ji Ming Wang, Naiming Zhou
The niacin receptor HCA2 is implicated in controlling inflammatory host responses with yet poorly understood mechanistic basis. We previously reported that HCA2 in A431 epithelial cells transduced Gβγ-protein kinase C- and Gβγ-metalloproteinase/EGFR-dependent MAPK/ERK signaling cascades. Here, we investigated the role of HCA2 in macrophage-mediated inflammation and the underlying mechanisms. We found that proinflammatory stimulants LPS, IL-6 and IL-1β up-regulated the expression of HCA2 on macrophages...
February 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28181870/accounting-for-the-process-of-disablement-and-longitudinal-outcomes-among-the-near-elderly-and-elderly
#9
Kalman Rupp, Irena Dushi
Using a new disability measure applicable to both the near elderly and elderly population, we track respondents aged 51-61 in 1992 from the Health and Retirement Study and account for their status over 20 years. We demonstrate that to screen in as disabled and to screen out as nondisabled require different analytic strategies and use multiple indicators to establish three groups: disabled, nondisabled, and a residual category with ambiguous status. We use work-disability and Supplemental Security Income/Disability Insurance (SSI/DI) receipt for testing distributional outcomes and assessing face validity of our disability measure...
January 2017: Research on Aging
https://www.readbyqxmd.com/read/28178129/chaperonin-hsp60-and-annexin-2-are-candidate-biomarkers-for-non-small-cell-lung-carcinoma
#10
İsmail Ağababaoğlu, Ahmet Önen, Ayşe Banu Demir, Safiye Aktaş, Zekiye Altun, Hasan Ersöz, Aydn Şanl, Nezih Özdemir, Atila Akkoçlu
BACKGROUND: Lung cancer is responsible of 12.4% and 17.6% of all newly diagnosed cancer cases and mortality due to cancer, respectively, and 5-year survival rate despite all improved treatment options is 15%. This survival rate reaches 66% in the Stage 1 and surgically treated patients. Early diagnosis which could not be definitely and commonly achieved yet is extremely critical in obtaining high survival rate in this disease. For this reason; proteomic differences were evaluated using matrix assisted laser desorption ionization (MALDI) mass spectrometry in the subgroups of lung adenocarcinoma and squamous cell carcinoma...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28169172/molecular-characterisation-of-anaplasma-species-from-african-buffalo-syncerus-caffer-in-kruger-national-park-south-africa
#11
Danielle Sisson, Jasmin Hufschmid, Anna Jolles, Brianna Beechler, Abdul Jabbar
Bovine anaplasmosis is a tick-borne disease, mainly caused by Anaplasma marginale and A. centrale and is distributed in tropical and sub-tropical areas. This study aimed to characterise A. marginale and A. centrale from African buffaloes in Kruger National Park (KNP), South Africa, using the DNA sequences of the genes coding for major surface protein (msp1β) and heat shock protein (groEL), respectively. A total of 747 blood samples were collected from February 2014 to August 2016 from African buffaloes kept in KNP, and DNAs were tested using a molecular-phylogenetic approach...
January 17, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/28168616/plant-response-to-engineered-metal-oxide-nanoparticles
#12
REVIEW
Khwaja Salahuddin Siddiqi, Azamal Husen
All metal oxide nanoparticles influence the growth and development of plants. They generally enhance or reduce seed germination, shoot/root growth, biomass production and physiological and biochemical activities. Some plant species have not shown any physiological change, although significant variations in antioxidant enzyme activity and upregulation of heat shock protein have been observed. Plants have evolved antioxidant defence mechanism which involves enzymatic as well as non-enzymatic components to prevent oxidative damage and enhance plant resistance to metal oxide toxicity...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28163177/venous-shunt-versus-venous-ligation-for-vascular-damage-control-the-immuno-histochemical-evidence
#13
Adenauer Marinho de Oliveira Góes Junior, Simone de Campos Vieira Abib, Maria Teresa de Seixas Alves, Paulo Sérgio Venerando da Silva Ferreira, Mariseth Carvalho de Andrade
OBJECTIVES: To evaluate the expression of immuno-histochemical markers of tissue ischemia (iNOS, eNOS and HSP70) in a vascular damage control experimental model in order to determine if a venous temporary vascular shunt insertion leads to a better limb perfusion when compared to the ligature of the injured vein. METHODS: Experimental study in male Sus Scrofa weighting 40 Kg. Animals were distributed into 5 groups: group 1 animals were submitted to right external iliac artery (EIA) shunting and right external iliac vein (EIV) ligation; group 2 animals were submitted to right EIA shunting and right EIV shunting; group 3 animals were submitted to right EIV ligation; group 4 animals were submitted to right EIV shunting; group 5 animals were not submitted to vascular shunting nor venous ligation...
February 2, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28152098/genome-wide-association-analysis-for-heat-tolerance-at-flowering-detected-a-large-set-of-genes-involved-in-adaptation-to-thermal-and-other-stresses
#14
Tanguy Lafarge, Crisanta Bueno, Julien Frouin, Laval Jacquin, Brigitte Courtois, Nourollah Ahmadi
Fertilization sensitivity to heat in rice is a major issue within climate change scenarios in the tropics. A panel of 167 indica landraces and improved varieties was phenotyped for spikelet sterility (SPKST) under 38°C during anthesis and for several secondary traits potentially affecting panicle micro-climate and thus the fertilization process. The panel was genotyped with an average density of one marker per 29 kb using genotyping by sequencing. Genome-wide association analyses (GWAS) were conducted using three methods based on single marker regression, haplotype regression and simultaneous fitting of all markers, respectively...
2017: PloS One
https://www.readbyqxmd.com/read/28144784/bag3-is-involved-in-neuronal-differentiation-and-migration
#15
Antonietta Santoro, Vanessa Nicolin, Fulvio Florenzano, Alessandra Rosati, Mario Capunzo, Stefania L Nori
Bcl2-associated athanogene 3 (BAG3) protein belongs to the family of co-chaperones interacting with several heat shock proteins. It plays a key role in protein quality control and mediates the clearance of misfolded proteins. Little is known about the expression and cellular localization of BAG3 during nervous system development and differentiation. Therefore, we analyze the subcellular distribution and expression of BAG3 in nerve-growth-factor-induced neurite outgrowth in PC12 cells and in developing and adult cortex of mouse brain...
February 1, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/28138251/apoptotic-induction-and-inhibition-of-nf-%C3%AE%C2%BAb-signaling-pathway-in-human-prostatic-cancer-pc3-cells-by-natural-compound-2-2-oxybis-4-allyl-1-methoxybenzene-biseugenol-b-from-litsea-costalis-an-in-vitro-study
#16
Maryam Abbaspour Babaei, Hasniza Zaman Huri, Behnam Kamalidehghan, Swee Keong Yeap, Fatemeh Ahmadipour
Litsea is considered as an evergreen genus distributed in tropical and subtropical Asia; this genus belongs to the large family of Lauraceae. In this study, the cell-death metabolism of biseugenol B was investigated. Nuclear condensation, cell permeability, mitochondrial membrane potential (MMP) and release of cytochrome c have been detected in human prostate cancer cell line (PC3) treated with biseugenol B by high content screening (HCS). Fluorescent analysis was conducted to examine the reactive oxygen species formation...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28134819/ultrafast-fiber-bragg-grating-interrogation-for-sensing-in-detonation-and-shock-wave-experiments
#17
George Rodriguez, Steve M Gilbertson
Chirped fiber Bragg grating (CFBG) sensors coupled to high speed interrogation systems are described as robust diagnostic approaches to monitoring shock wave and detonation front propagation tracking events for use in high energy density shock physics applications. Taking advantage of the linear distributed spatial encoding of the spectral band in single-mode CFBGs, embedded fiber systems and associated photonic interrogation methodologies are shown as an effective approach to sensing shock and detonation-driven loading processes along the CFBG length...
January 27, 2017: Sensors
https://www.readbyqxmd.com/read/28128746/no-relationship-between-red-blood-cell-distribution-width-and-microcirculatory-alterations-in-septic-patients
#18
Vito Fontana, Savino Spadaro, Ottavia Bond, Federica Zama Cavicchi, Filippo Annoni, Katia Donadello, Jean-Louis Vincent, Daniel De Backer, Fabio Silvio Taccone
BACKGROUND: Increased red cell distribution width (RDW), a quantitative measure of erythrocyte size variability, has been associated with increased mortality in critically ill patients. METHODS: In this post-hoc analysis of prospectively collected data, we studied 122 septic patients with and without shock who had undergone sublingual microcirculatory assessment using Sidestream Dark Field (SDF) videomicroscopy. Patient demographics, comorbidities, the Acute Physiology and Chronic Health Evaluation (APACHE) II score on admission and the Sequential Organ Failure Assessment (SOFA) score on the day of the microcirculatory assessment were collected...
January 27, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28128627/thermodynamic-and-kinetic-properties-of-shocks-in-two-dimensional-yukawa-systems
#19
M Marciante, M S Murillo
Particle-level simulations of shocked plasmas are carried out to examine kinetic properties not captured by hydrodynamic models. In particular, molecular dynamics simulations of 2D Yukawa plasmas with variable couplings and screening lengths are used to examine shock features unique to plasmas, including the presence of dispersive shock structures for weak shocks. A phase-space analysis reveals several kinetic properties, including anisotropic velocity distributions, non-Maxwellian tails, and the presence of fast particles ahead of the shock, even for moderately low Mach numbers...
January 13, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28128357/multilevel-interaction-of-the-dnak-dnaj-hsp70-hsp40-stress-responsive-chaperone-machine-with-the-central-metabolism
#20
Fréderic Anglès, Marie-Pierre Castanié-Cornet, Nawel Slama, Mickael Dinclaux, Anne-Marie Cirinesi, Jean-Charles Portais, Fabien Létisse, Pierre Genevaux
Networks of molecular chaperones maintain cellular protein homeostasis by acting at nearly every step in the biogenesis of proteins and protein complexes. Herein, we demonstrate that the major chaperone DnaK/HSP70 of the model bacterium Escherichia coli is critical for the proper functioning of the central metabolism and for the cellular response to carbon nutrition changes, either directly or indirectly via the control of the heat-shock response. We identified carbon sources whose utilization was positively or negatively affected by DnaK and isolated several central metabolism genes (among other genes identified in this work) that compensate for the lack of DnaK and/or DnaK/Trigger Factor chaperone functions in vivo...
January 27, 2017: Scientific Reports
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