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Flinders Medical

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https://www.readbyqxmd.com/read/29132146/identification-of-unique-neoantigen-qualities-in-long-term-survivors-of-pancreatic-cancer
#1
Vinod P Balachandran, Marta Łuksza, Julia N Zhao, Vladimir Makarov, John Alec Moral, Romain Remark, Brian Herbst, Gokce Askan, Umesh Bhanot, Yasin Senbabaoglu, Daniel K Wells, Charles Ian Ormsby Cary, Olivera Grbovic-Huezo, Marc Attiyeh, Benjamin Medina, Jennifer Zhang, Jennifer Loo, Joseph Saglimbeni, Mohsen Abu-Akeel, Roberta Zappasodi, Nadeem Riaz, Martin Smoragiewicz, Z Larkin Kelley, Olca Basturk, Mithat Gönen, Arnold J Levine, Peter J Allen, Douglas T Fearon, Miriam Merad, Sacha Gnjatic, Christine A Iacobuzio-Donahue, Jedd D Wolchok, Ronald P DeMatteo, Timothy A Chan, Benjamin D Greenbaum, Taha Merghoub, Steven D Leach
Pancreatic ductal adenocarcinoma is a lethal cancer with fewer than 7% of patients surviving past 5 years. T-cell immunity has been linked to the exceptional outcome of the few long-term survivors, yet the relevant antigens remain unknown. Here we use genetic, immunohistochemical and transcriptional immunoprofiling, computational biophysics, and functional assays to identify T-cell antigens in long-term survivors of pancreatic cancer. Using whole-exome sequencing and in silico neoantigen prediction, we found that tumours with both the highest neoantigen number and the most abundant CD8+ T-cell infiltrates, but neither alone, stratified patients with the longest survival...
November 23, 2017: Nature
https://www.readbyqxmd.com/read/29072509/matthew-flinders-senior-1751-1802-surgeon-and-man-midwife
#2
Linda Shields, Julie Jomeen, Wendy Smyth, David Stanley
Until the eighteenth century, midwifery was the sole domain of women, but changes in medical science saw it appropriated by medical men and the 'man-midwife' emerged. This paper demonstrates the work of a man-midwife in a small English village in one year, 1775, using his accounts and correspondence. The man was Matthew Flinders Senior, 'surgeon and man-midwife' at Donington, Lincolnshire. He was the father of Captain Matthew Flinders, the famous navigator who mapped the coast line of Australia and who coined that name...
January 1, 2017: Journal of Medical Biography
https://www.readbyqxmd.com/read/28994188/natural-history-of-endoscopically-detected-hiatus-herniae-at-late-follow-up
#3
Syeda Khadijah Ahmed, Tim Bright, David I Watson
BACKGROUND: Hiatus herniae are commonly seen at endoscopy. Many patients with a large hiatus hernia are endoscoped for symptoms associated with the hernia and many of these will progress to surgical treatment. However, little is known about the natural history of small to medium size hiatus herniae, and their risk of progressing to a larger hernia requiring surgery. This study aims to determine the need for subsequent surgery in these patients. METHODS: A retrospective audit of the endoscopy database at Flinders Medical Centre and the Repatriation General Hospital in Adelaide, South Australia for the 2-year period 2002-2003 was performed to identify all patients with a hiatus hernia...
October 9, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28835321/managing-chronic-conditions-care-across-primary-care-and-hospital-systems-lessons-from-an-australian-hospital-avoidance-risk-program-using-the-flinders-chronic-condition-management-program
#4
Sharon Lawn, Sara Zabeen, David Smith, Ellen Wilson, Cathie Miller, Malcolm Battersby, Kevin Masman
Objective The study aimed to determine the impact of the Flinders Chronic Condition Management Program for chronic condition self-management care planning and how to improve its use with Bendigo Health's Hospital Admission Risk Program (HARP).Methods A retrospective analysis of hospital admission data collected by Bendigo Health from July 2012 to September 2013 was undertaken. Length of stay during admission and total contacts post-discharge by hospital staff for 253 patients with 644 admissions were considered as outcome variables...
August 24, 2017: Australian Health Review: a Publication of the Australian Hospital Association
https://www.readbyqxmd.com/read/28488309/medical-students-experience-of-performing-female-pelvic-examinations-opportunities-and-barriers
#5
Harsh Bhoopatkar, Andy Wearn, Anna Vnuk
BACKGROUND: Teaching and learning female pelvic examination within the undergraduate medical curriculum offers some potential challenges. One such is the extent to which students are provided practice opportunities with patients in the clinical setting. AIMS: To quantify how many pelvic examinations, on real patients, have been performed by medical students at the point of graduation, and to explore opportunities and barriers to performing these examinations. MATERIALS AND METHODS: A retrospective study using a self-completed, anonymous, electronic survey was developed as part of a multi-centre study...
October 2017: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28403767/tick-borne-infectious-diseases-in-australia
#6
REVIEW
Stephen R Graves, John Stenos
Tick bites in Australia can lead to a variety of illnesses in patients. These include infection, allergies, paralysis, autoimmune disease, post-infection fatigue and Australian multisystem disorder. Rickettsial (Rickettsia spp.) infections (Queensland tick typhus, Flinders Island spotted fever and Australian spotted fever) and Q fever (Coxiella burnetii) are the only systemic bacterial infections that are known to be transmitted by tick bites in Australia. Three species of local ticks transmit bacterial infection following a tick bite: the paralysis tick (Ixodes holocyclus) is endemic on the east coast of Australia and causes Queensland tick typhus due to R...
April 17, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/27881092/the-relationship-between-in-hospital-location-and-outcomes-of-care-in-patients-diagnosed-with-dementia-and-or-delirium-diagnoses-analysis-of-patient-journey
#7
COMPARATIVE STUDY
Lua Perimal-Lewis, Clare Bradley, Paul H Hakendorf, Craig Whitehead, Louise Heuzenroeder, Maria Crotty
BACKGROUND: The discrepancy between the number of admissions and the allocation of hospital beds means that many patients admitted to hospital can be placed in units or wards other than that which specialise in the patient's primary health issue (home-ward). These patients are called 'outlier' patients. Risk factors and health system outcomes of hospital care for 'outlier' patients diagnosed with dementia and/or delirium are unknown. Therefore, the aim of this research was to examine patient journeys of people with dementia and/or delirium diagnoses, to identify risk factors for 'inlier' or 'outlier' status and patient or health system outcomes (consequences) of this status...
November 24, 2016: BMC Geriatrics
https://www.readbyqxmd.com/read/27773117/comparing-expected-ratios-of-diagnostic-categories-of-thyroid-fine-needle-aspirates-at-flinders-medical-centre-fmc-using-old-reporting-systems-versus-the-new-rcpa-recommended-australasian-system
#8
https://www.readbyqxmd.com/read/27734613/pregnancy-screening-prior-to-chemotherapy-administration
#9
L Hu, G Kichenadasse, H Martin, A Roy, S Sukumaran, S Vatandoust, B Koczwara, C S Karapetis
A retrospective case notes review was performed to determine compliance with screening for undetected pregnancy prior to commencement of chemotherapy at Flinders Medical Centre. All female patients aged 18-55 who commenced chemotherapy between January and December 2014 were included. During the first 12 months, for women identified as having childbearing potential, pre-chemotherapy pregnancy screening was performed only in 40% of patients under 40 years and in 20.5% of the entire age range.
October 2016: Internal Medicine Journal
https://www.readbyqxmd.com/read/27695727/urban-general-practice-and-medical-education-academic-outcomes-from-a-unique-urban-longitudinal-integrated-community-based-program
#10
Sarah Mahoney, Paul Worley, Helen Parry, Sally Clarke
BACKGROUND: In 2009, Flinders University established an urban, community-based, longitudinal integrated program providing medical students extended placements that offered continuities of patient care, clinical supervision and peer group. OBJECTIVE: The aim of this research was to analyse academic outcomes of the new placement program. METHODS: The results of all students undertaking Year 3 exams from 2011 to 2014 were collected and analysed...
October 2016: Australian Family Physician
https://www.readbyqxmd.com/read/27605523/emergency-psychiatry-a-product-of-circumstance-or-a-growing-sub-speciality-field
#11
Paul Cammell
OBJECTIVES: This article reviews recent trends in the provision of psychiatric services to the emergency departments of tertiary hospitals in Australia, involving the establishment of specialised in-reach or liaison services as well as various forms of short stay unit attached to emergency departments. The Emergency Psychiatry Service at Flinders Medical Centre, South Australia, is described as a case example. Its specialised models of assessment and clinical care are described, highlighting how these are differentiated from more traditional models in inpatient, community and general hospital consultation-liaison psychiatry...
February 2017: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/27450570/predicting-success-in-medical-school-a-longitudinal-study-of-common-australian-student-selection-tools
#12
Ruth M Sladek, Malcolm J Bond, Linda K Frost, Kirsty N Prior
BACKGROUND: Medical student selection and assessment share an underlying high stakes context with the need for valid and reliable tools. This study examined the predictive validity of three tools commonly used in Australia: previous academic performance (Grade Point Average (GPA)), cognitive aptitude (a national admissions test), and non-academic qualities of prospective medical students (interview). METHODS: A four year retrospective cohort study was conducted at Flinders University Australia involving 382 graduate entry medical students first enrolled between 2006 and 2009...
July 22, 2016: BMC Medical Education
https://www.readbyqxmd.com/read/27389059/goserelin-toxicities-and-preferences-for-ovarian-suppression-method-in-pre-menopausal-women-with-breast-cancer
#13
A H-C Hsieh, G Kichenadasse, S Vatandoust, A Roy, S Sukumaran, C S Karapetis, H Martin, L C Chong, B Koczwara
BACKGROUND: Goserelin, a form of medical ovarian suppression, is an effective treatment for pre-menopausal women with breast cancer (PMBC). Meta-analysis data showed that similar efficacy is achieved with medical ovarian suppression and non-pharmacological ovarian suppression (NPOS) - oophorectomy or ovarian irradiation. The acceptance rate of NPOS remains low. AIMS: This study explored the reported toxicities of PMBC women and their preferred ovarian suppression method whilst on goserelin...
October 2016: Internal Medicine Journal
https://www.readbyqxmd.com/read/27367510/genetic-association-at-the-9p21-glaucoma-locus-contributes-to-sex-bias-in-normal-tension-glaucoma
#14
Soo Khai Ng, Kathryn P Burdon, Jude T Fitzgerald, Tiger Zhou, Rhys Fogarty, Emmanuelle Souzeau, John Landers, Richard A Mills, Robert J Casson, Bronwyn Ridge, Stuart L Graham, Alex W Hewitt, David A Mackey, Paul R Healey, Jie Jin Wang, Paul Mitchell, Stuart MacGregor, Jamie E Craig
PURPOSE: Many genome-wide association studies have identified common single nucleotide polymorphisms (SNPs) at the 9p21 glaucoma locus (CDKN2B/CDKN2B-AS1) to be significantly associated with primary open-angle glaucoma (POAG), with association being stronger in normal tension glaucoma (NTG) and advanced glaucoma. We aimed to determine whether any observed differences in genetic association at the 9p21 locus are influenced by sex. METHODS: Sex was assessed as a risk factor for POAG for 2241 glaucoma participants from the Australian and New Zealand Registry of Advanced Glaucoma, the Glaucoma Inheritance Study in Tasmania, and the Flinders Medical Centre...
June 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27341418/clinical-conundrums-how-safe-is-exercise-in-patients-with-asthma-and-is-high-flow-nasal-oxygen-useful-in-respiratory-failure
#15
Reynolds Gaw, Carissa Yap, Sarah M Newhouse, Vinod Aiyappan
No abstract text is available yet for this article.
September 1, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27248161/global-sharing-local-innovation-four-schools-four-countries-one-curriculum
#16
Luís Castelo-Branco, Paul Finucane, Pedro Marvão, Peter McCrorie, José Ponte, Paul Worley
BACKGROUND: Many internal and external obstacles, must be overcome when establishing a new medical school, or when radically revising an existing medical curriculum. AIMS: Twenty-five years after the Flinders University curriculum was introduced as the first graduate-entry medical programme (GEMP) in Australia, we aim at describing how it has been adopted and adapted by several other schools, in Australia and in Europe (UK, Ireland, and Portugal). METHOD/RESULTS: This paper reports on the experience of four schools establishing a new medical school or new curriculum at different times and in different settings...
December 2016: Medical Teacher
https://www.readbyqxmd.com/read/27239650/relationship-of-side-dominance-and-ultrasonographic-measurements-of-pronator-quadratus-muscle-along-with-handgrip-and-pinch-strength
#17
Nusret Ok, Kadir Agladioglu, Harun R Gungor, Ali Kitis, Semih Akkaya, Nuran Sabir Akkoyunlu, Fahir Demirkan
AIMS: We ascertained effects of hand dominance in both right and left-handed volunteers on the thickness and cross sectional area (CSA) of pronator quadratus (PQ) muscle as measured by the axial and sagittal views of ultrasound imaging. Secondly, we also aimed to document the extent of the relationship between the PQ measurements and handgrip. MATERIALS AND METHODS: Healthy adults from the volunteer medical staff were included in the study. Handedness was assessed via The Flinders Handedness survey...
June 2016: Medical Ultrasonography
https://www.readbyqxmd.com/read/26774829/depression-screening-after-cardiac-surgery-a-six-month-longitudinal-follow-up-for-cardiac-events-hospital-readmissions-quality-of-life-and-mental-health
#18
Phillip J Tully, Harald Baumeister, Jayme S Bennetts, Greg D Rice, Robert A Baker
OBJECTIVES: To report the 6-month longitudinal outcomes of routine depression screening in cardiac patients. METHODS: Routine depression screening consisted of the Patient Health Questionnaire (PHQ) administered 30-days after cardiac surgery at the Flinders Medical Centre, South Australia. Complete data was obtained on 481 patients who were subdivided into three groups; depressed-cardiac control determined by current anti-depressant use or history of depression in medical records (n=90), depression screen-positives (PHQ≥10, n=46) and depression screen-negatives (PHQ≤9, n=345)...
March 1, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/26687286/comparing-surgical-experience-with-performance-on-a-sinus-surgery-simulator
#19
Laura E Diment, Greg S Ruthenbeck, Nuwan Dharmawardana, A Simon Carney, Charmaine M Woods, Eng H Ooi, Karen J Reynolds
BACKGROUND: This study evaluates whether surgical experience influences technical competence using the Flinders sinus surgery simulator, a virtual environment designed to teach nasal endoscopic surgical skills. METHODS: Ten experienced sinus surgeons (five consultants and five registrars) and 14 novices (seven resident medical officers and seven interns/medical students) completed three simulation tasks using haptic controllers. Task 1 required navigation of the sinuses and identification of six anatomical landmarks, Task 2 required removal of unhealthy tissue while preserving healthy tissue and Task 3 entailed backbiting within pre-set lines on the uncinate process and microdebriding tissue between the cuts...
December 2016: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/26140527/ibopamine-challenge-testing-differentiates-glaucoma-suspect-stable-glaucoma-and-progressive-glaucoma-cases
#20
John Landers, Katja Ullrich, Jamie E Craig
BACKGROUND: An ibopamine challenge is a novel technique for assessing glaucoma using ibopamine, a topical drug which temporarily increases aqueous production. We aimed to determine whether change in intraocular pressure (IOP) and/or optic cup volume (OCV) during the test differentiated between glaucoma patients at different stages of disease; namely, glaucoma suspects (GS), glaucoma patients who are stable (SG) and glaucoma patients who have demonstrated rapid progression (PG). DESIGN: Non-randomized clinical trial evaluating a diagnostic test...
December 2015: Clinical & Experimental Ophthalmology
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