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https://www.readbyqxmd.com/read/28735292/pathogenesis-of-hypertrophic-cardiomyopathy-is-mutation-rather-than-disease-specific-a-comparison-of-the-cardiac-troponin-t-e163r-and-r92q-mouse-models
#1
Cecilia Ferrantini, Raffaele Coppini, Josè Manuel Pioner, Francesca Gentile, Benedetta Tosi, Luca Mazzoni, Beatrice Scellini, Nicoletta Piroddi, Annunziatina Laurino, Lorenzo Santini, Valentina Spinelli, Leonardo Sacconi, Pieter De Tombe, Rachel Moore, Jil Tardiff, Alessandro Mugelli, Iacopo Olivotto, Elisabetta Cerbai, Chiara Tesi, Corrado Poggesi
BACKGROUND: In cardiomyocytes from patients with hypertrophic cardiomyopathy, mechanical dysfunction and arrhythmogenicity are caused by mutation-driven changes in myofilament function combined with excitation-contraction (E-C) coupling abnormalities related to adverse remodeling. Whether myofilament or E-C coupling alterations are more relevant in disease development is unknown. Here, we aim to investigate whether the relative roles of myofilament dysfunction and E-C coupling remodeling in determining the hypertrophic cardiomyopathy phenotype are mutation specific...
July 22, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28735188/photoelectrochemical-pec-studies-on-cu2sns3-cts-thin-films-deposited-by-chemical-bath-deposition-method
#2
H D Shelke, A C Lokhande, J H Kim, C D Lokhande
Cu2SnS3 (CTS) thin films have been successfully deposited on a cost-effective stainless steel substrate by simple and inexpensive chemical bath deposition (CBD) method. The films are deliberated in provisos of their structural, morphological, optical and photoelectrochemical (PEC) properties before and after annealing treatment, using various physico-chemical techniques. The XRD studies showed the formation of triclinic phase of CTS films with nanocrystalline structure. Also, the crystallinity is enhanced with annealing and the secondary phase of Cu2S observed...
July 11, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28734310/stability-limits-for-the-supercooled-liquid-and-superheated-crystal-of-lennard-jones-particles
#3
Ernesto S Loscar, Daniel A Martin, Tomás S Grigera
We have studied the limits of stability in the first order liquid-solid phase transition in a Lennard-Jones system by means of the short-time relaxation method and using the bond-orientational order parameter Q6. These limits are compared with the melting line. We have paid special attention to the supercooled liquid, comparing our results with the point where the free energy cost of forming a nucleating droplet goes to zero. We also indirectly estimate the dimension associated to the critical nucleus at the spinodal, expected to be fractal according to mean field theories of nucleation...
July 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28734295/estimating-the-intrinsic-limit-of-the-feller-peterson-dixon-composite-approach-when-applied-to-adiabatic-ionization-potentials-in-atoms-and-small-molecules
#4
David Feller
Benchmark adiabatic ionization potentials were obtained with the Feller-Peterson-Dixon (FPD) theoretical method for a collection of 48 atoms and small molecules. In previous studies, the FPD method demonstrated an ability to predict atomization energies (heats of formation) and electron affinities well within a 95% confidence level of ±1 kcal/mol. Large 1-particle expansions involving correlation consistent basis sets (up to aug-cc-pV8Z in many cases and aug-cc-pV9Z for some atoms) were chosen for the valence CCSD(T) starting point calculations...
July 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28733882/prediction-of-the-lowest-charge-transfer-excited-state-energy-at-the-donor-acceptor-interface-in-a-condensed-phase-using-ground-state-dft-calculations-with-generalized-kohn-sham-functionals
#5
Shaohui Zheng, Mengyue Xiao, Yongping Tian, Xue Chen
Knowledge of the charge (electron) transfer process at the donor-acceptor interface is required to understand the working mechanisms of different organic photovoltaic materials. Investigating the lowest charge-transfer state in organic donor-acceptor solar cells is important as it allows the destruction/formation of excitons and polarons to be studied, and is directly related to the open circuit voltage. By performing low-cost and feasible calculations of ground-state electronic structures using the Mulliken rule as well as the optimally tuned range-separated hybrid (OTRSH) density functional and a regular long-range corrected functional, the lowest charge-transfer (CT) state energies of a series of dimers containing functionalized anthracene (the donor) and tetracyanoethylene (the acceptor) were obtained...
August 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28731732/observation-of-flat-electron-temperature-profiles-in-the-lithium-tokamak-experiment
#6
D P Boyle, R Majeski, J C Schmitt, C Hansen, R Kaita, S Kubota, M Lucia, T D Rognlien
It has been predicted for over a decade that low-recycling plasma-facing components in fusion devices would allow high edge temperatures and flat or nearly flat temperature profiles. In recent experiments with lithium wall coatings in the Lithium Tokamak Experiment (LTX), a hot edge (>200  eV) and flat electron temperature profiles have been measured following the termination of external fueling. Reduced recycling was demonstrated by retention of ∼60% of the injected hydrogen in the walls following the discharge...
July 7, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28731659/neonatal-intensive-care-unit-lighting-update-and-recommendations
#7
Roberto G Rodríguez, Andrea E Pattini
Achieving adequate lighting in neonatal intensive care units is a major challenge: in addition to the usual considerations of visual performance, cost, energy and aesthetics, there appear different biological needs of patients, health care providers and family members. Communicational aspects of light, its role as a facilitator of the visual function of doctors and nurses, and its effects on the newborn infant physiology and development were addressed in order to review the effects of light (natural and artificial) within neonatal care with a focus on development...
August 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28731640/are-products-sold-in-university-vending-machines-nutritionally-poor-a-food-environment-audit
#8
Amanda Grech, Lana Hebden, Rajshri Roy, Margaret Allman-Farinelli
AIM: (i) To audit the nutritional composition, promotion and cost of products available from vending machines available to young adults; and (ii) to examine the relationship between product availability and sales. METHODS: A cross-sectional analysis of snacks and beverages available and purchased at a large urban university was conducted between March and September 2014. Sales were electronically tracked for nine months. RESULTS: A total of 61 vending machines were identified; 95% (n = 864) of the available snacks and 49% of beverages (n = 455) were less-healthy items...
April 2017: Nutrition & Dietetics: the Journal of the Dietitians Association of Australia
https://www.readbyqxmd.com/read/28731629/stabilizing-the-performance-of-high-capacity-sulfur-composite-electrodes-by-a-novel-gel-polymer-electrolyte-configuration
#9
Marco Agostini, Du Hyun Lim, Matthew Sadd, Fasciani Chiara, Maria Assunta Navarra, Stefania Panero, Sergio Brutti, Aleksandar Matic, Bruno Scrosati
Increased pollution and the consequent increasing in global warming are drawing attention to the larger use of renewable energy sources such as solar or wind. However, the production of energy from most renewable sources is intermittent and thus relies on the availability of electrical energy storage systems with high capacity and at competitive cost. Lithium-sulfur batteries are among the most promising technologies in this respect due to a very high theoretical energy density (1675 mAh g-1) and that the active material, S, is abundant and cheap...
July 21, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28730357/biosynthesis-of-silver-nanoparticles-from-spirulina-microalgae-and-its-antibacterial-activity
#10
Govarthanan Muthusamy, Selvankumar Thangasamy, Mythili Raja, Sudhakar Chinnappan, Selvam Kandasamy
The present work focuses on a low-cost, simple, and green synthesis of silver nanoparticles (AgNPs) by mixing AgNO3 solution with the extract of Spirulina platensis (SP) without any chemical reducing and/or capping agents. The green synthesis of AgNPs was confirmed by the color change from colorless to yellowish brown. The biosynthesis of AgNPs was further confirmed by UV-visible spectroscopy (UV-vis), Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), biological transmission electron microscopy (Bio-TEM), and energy dispersive X-ray analysis (EDX)...
July 20, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28730068/stroke-survivors-levels-of-community-reintegration-quality-of-life-satisfaction-with-the-physiotherapy-services-and-the-level-of-caregiver-strain-at-community-health-centres-within-the-johannesburg-area
#11
Adrian Kusambiza-Kiingi, Douglas Maleka, Veronica Ntsiea
BACKGROUND: Stroke survivors are discharged home before they are functionally independent and return home with activity limitations that would not be manageable without a caregiver. AIM: To determine stroke survivors' levels of community reintegration, quality of life (QOL), satisfaction with the physiotherapy services and the level of caregiver strain at community health centres within the Johannesburg area. METHOD: This was a cross-sectional study using the following outcome measures: Maleka Stroke Community Reintegration Measure, Stroke-specific quality of life scale, Caregiver strain index and Physical therapy patient satisfaction questionnaire...
2017: Afr J Disabil
https://www.readbyqxmd.com/read/28729627/a-mechanism-based-qstr-model-for-acute-to-chronic-toxicity-extrapolation-a-case-study-of-antibiotics-on-luminous-bacteria
#12
Dali Wang, Yue Gu, Min Zheng, Wei Zhang, Zhifen Lin, Ying Liu
The determination of the chronic toxicity is time-consumed and costly, so it's of great interest to predict the chronic toxicity based on acute data. Current methods include the acute to chronic ratios (ACRs) and the QSTR models, both of which have some usage limitations. In this paper, the acute and chronic mixture toxicity of three types of antibiotics, namely sulfonamides, sulfonamide potentiators and tetracyclines, were determined by a bioluminescence inhibition test. A novel QSTR model was developed for predicting the chronic mixture toxicity using the acute data and docking-based descriptors...
July 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28729530/achieving-ultrahigh-triboelectric-charge-density-for-efficient-energy-harvesting
#13
Jie Wang, Changsheng Wu, Yejing Dai, Zhihao Zhao, Aurelia Wang, Tiejun Zhang, Zhong Lin Wang
With its light weight, low cost and high efficiency even at low operation frequency, the triboelectric nanogenerator is considered a potential solution for self-powered sensor networks and large-scale renewable blue energy. As an energy harvester, its output power density and efficiency are dictated by the triboelectric charge density. Here we report a method for increasing the triboelectric charge density by coupling surface polarization from triboelectrification and hysteretic dielectric polarization from ferroelectric material in vacuum (P ~ 10(-6) torr)...
July 20, 2017: Nature Communications
https://www.readbyqxmd.com/read/28729344/exogenous-stress-hormones-alter-energetic-and-nutrient-costs-of-development-and-metamorphosis
#14
Lucas J Kirschman, Marshall D McCue, Justin G Boyles, Robin W Warne
Variation in environmental conditions during larval life stages can shape development during critical windows and have lasting effects on the adult organism. Changes in larval developmental rates in response to environmental conditions, for example, can trade-off with growth to determine body size and condition at metamorphosis, which can affect adult survival and fecundity. However, it is unclear how use of energy and nutrients shape trade-offs across life stage transitions because no studies have quantified these costs of larval development and metamorphosis...
July 20, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28729044/the-clinical-utility-of-vertebral-fracture-assessment-in-predicting-fractures
#15
Joao Lindolfo C Borges, Isabella Santiago de M Miranda, E Michael Lewiecki
Vertebral fracture (VF) is the most common type of osteoporotic fracture. VFs are associated with diminished quality of life and high morbidity and mortality. The presence of a VF, especially a recent one, is an important risk factor for developing another fracture. However, most VFs are not clinically recognized. VF assessment by dual-energy X-ray absorptiometry is a convenient, low-cost, low-radiation, reliable method to identify VFs during bone mineral density measurement. The finding of a previously unrecognized VF may change the diagnostic classification, assessment of fracture risk, and treatment strategies...
July 18, 2017: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/28728959/mechanisms-contributing-to-gait-speed-and-metabolic-cost-in-children-with-unilateral-cerebral-palsy
#16
Tatiana Pessoa Silva Pinto, Sérgio Teixeira Fonseca, Rejane Vale Gonçalves, Thales Rezende Souza, Daniela Virgínia Vaz, Paula Lanna Pereira Silva, Marisa Cotta Mancini
BACKGROUND: Gait speed and metabolic cost are indicators of functional capacity in children with cerebral palsy. Uncovering their mechanisms helps guide therapeutic actions. OBJECTIVES: To investigate the contributions of energy-generating and energy-conserving mechanisms to gait speed and metabolic cost of children with unilateral cerebral palsy. METHODS: Data on eccentric and concentric muscle work, co-contraction, elastic torque and vertical stiffness of the affected-limb, forcing torque of the non-affected limb, gait speed and metabolic cost were collected from 14 children with unilateral cerebral palsy, aged 6-12 years...
July 5, 2017: Brazilian Journal of Physical Therapy
https://www.readbyqxmd.com/read/28726989/economic-selection-index-development-for-beefmaster-cattle-ii-general-purpose-breeding-objective
#17
K P Ochsner, M D MacNeil, R M Lewis, M L Spangler
An economic selection index was developed for Beefmaster cattle in a general-purpose production system in which bulls are mated to a combination of heifers and mature cows, with resulting progeny retained as replacements or sold at weaning. National average prices from 2010 to 2014 were used to establish income and expenses for the system. Genetic parameters were obtained from the literature. Economic values were estimated by simulating 100,000 animals and approximating the partial derivatives of the profit function by perturbing traits 1 at a time, by 1 unit, while holding the other traits constant at their respective means...
May 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28726885/simulation-of-the-experimental-imaging-results-for-the-oh-chd3-reaction-with-a-simple-and-accurate-theoretical-approach
#18
Laurent Bonnet, Joaquin Espinosa-Garcia
The OH + CHD3 reaction is among the largest one ever studied at the high-resolution level permitted by imaging techniques [B. Zhang et al., J. Phys. Chem. A, 2005, 109, 8989]. This process involves eighteen configuration space coordinates, which are large enough to make exact quantum scattering calculations beyond reach. Moreover, freezing some degrees-of-freedom in order to render these calculations feasible may lead to unrealistic predictions. However, we have found it possible to reproduce for the first time the pair-correlated measurements of Zhang et al...
July 20, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28726685/enhanced-thermoelectric-performance-of-bi-sub-2-sub-te-sub-3-sub-by-uniform-dispersion-of-single-wall-carbon-nanotubes
#19
Kaleem Ahmad, Chunlei Wan
The advancement in nanostructured powder processing has attracted recently great interest as a cost effective and scalable strategy for high performance thermoelectric bulks. However, the level of technical breakthrough as realized in quantum dot supperlattice/wire has not yet demonstrated in these materials. Here, we report first ever study on the uniform dispersion of single wall carbon nanotubes (SWCNTs) in nanostructured Bi2Te3 bulk and their effect on thermoelectric parameters above room temperature. The Bi<sub>2</sub>Te<sub>3</sub> based SWCNTs composites were prepared through controlled powder processing and their thermoelectric properties were finely tuned at nanoscale by regulating various (0...
July 20, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28725450/various-levels-of-copra-meal-supplementation-with-%C3%AE-mannanase-on-growth-performance-blood-profile-nutrient-digestibility-pork-quality-and-economical-analysis-in-growing-finishing-pigs
#20
H J Kim, S O Nam, J H Jeong, L H Fang, H B Yoo, S H Yoo, J S Hong, S W Son, S H Ha, Y Y Kim
BACKGROUND: To reduce use of main feed ingredient like corn, soy bean meal (SBM) and wheat, alternative ingredients has been studied like copra meal (CM). Production amount of CM which has been high makes CM to be an alternative feed stuff. However, low digestibility on AA and low energy content by high fiber content can be an obstacle for using CM. This experiment was conducted to evaluate the effects of CM supplementation with β-mannanase on growth performance, blood profile, nutrient digestibility, pork quality and economic analysis in growing-finishing pigs...
2017: Journal of Animal Science and Technology
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