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Injectable hydrogels

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https://www.readbyqxmd.com/read/29916734/polymeric-injectable-intravitreal-hydrogel-devices-for-posterior-segment-applications-and-interventions
#1
Muhammed Anwary, Pradeep Kumar, Lisa C du Toit, Yahya E Choonara, Viness Pillay
Posterior segment diseases are commonly implicated in the occurrence of curable as well as incurable diseases which could lead to blindness. An example of one such disease is age-related macular degeneration, which would require chronic treatment over an extended period and as such the development of an intravitreal drug delivery system that would optimize patient outcomes is essential. The major contributor of the difficulty in treating diseases in the posterior segment is the structure of the eye, particularly the blood-ocular barriers...
June 19, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29902729/collagen-chitosan-hyaluronic-acid-based-injectable-hydrogels-for-tissue-engineering-applications-design-physicochemical-and-biological-characterization
#2
Adriana Gilarska, Joanna Lewandowska-Łańcucka, Wojciech Horak, Maria Nowakowska
Studies on synthesis, physico-chemical and biological properties of novel biomimetic materials, potentially useful as injectable hydrogels are presented. These materials are in situ prepared chemically crosslinked collagen/chitosan/hyaluronic acid-based hydrogels exhibiting potential for tissue regeneration. Optimization of hydrogels involved testing the effect of various concentration of crosslinking agent (genipin) as well as different ratios of biopolymers used on their properties. The changes in the content of hyaluronic acid and in the genipin concentration used have been shown to be crucial...
June 4, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29891731/local-bdnf-delivery-to-the-injured-cervical-spinal-cord-using-an-engineered-hydrogel-enhances-diaphragmatic-respiratory-function
#3
Biswarup Ghosh, Zhicheng Wang, Jia Nong, Mark W Urban, Zhiling Zhang, Victoria A Trovillion, Megan C Wright, Yinghui Zhong, Angelo C Lepore
We developed an innovative biomaterial-based approach to repair the critical neural circuitry that controls diaphragm activation by locally delivering brain-derived neurotrophic factor (BDNF) to injured cervical spinal cord. BDNF can be used to restore respiratory function via a number of potential repair mechanisms; however, widespread BDNF biodistribution resulting from delivery methods such as systemic injection or lumbar puncture can lead to inefficient drug delivery and adverse side effects. As a viable alternative, we developed a novel hydrogel-based system loaded with polysaccharide-BDNF particles self-assembled by electrostatic interactions that can be safely implanted in the intrathecal space for achieving local BDNF delivery with controlled dosing and duration...
June 11, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29891313/effect-of-vitamin-derivatives-on-gelation-rate-and-gel-strength-of-methylcellulose
#4
Min Hee Kim, Hanna Park, Ji Youn Shin, Won Ho Park
A thermo-sensitive methylcellulose (MC) hydrogel was prepared using three types of vitamin derivatives with or without phosphate groups. The gelation behavior of each MC hydrogel containing vitamin or vitamin derivatives was monitored using a rheometer. The gelation rate and mechanical strength of the MC hydrogels were improved by vitamin derivatives with phosphate groups due to their salting-out effects, whereas their injectabilities retained proper maximum forces. Also, the vitamin derivatives with phosphate groups were released slower from the MC hydrogel than the vitamins without phosphate groups due to higher physical crosslinking densities...
September 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29889043/injectable-hydrogels-as-novel-materials-for-central-nervous-system-regeneration
#5
Beata Niemczyk, Paweł Łukasz Sajkiewicz, Dorota Kolbuk
Injuries of the central nervous system (CNS) can cause serious and permanent disability due to limited regeneration ability of the CNS. Presently available therapies are focused on lesion spreading inhibition rather than on tissue regeneration. Recent investigations in the field of neural tissue engineering indicate extremely promising properties of novel injectable and non-injectable hydrogels which are tailored to serve as biodegradable scaffolds for CNS regeneration. 
 This review discusses the state-of-the-art and barriers in application of novel polymer-based hydrogels without and with nanoparticles for CNS regeneration...
June 11, 2018: Journal of Neural Engineering
https://www.readbyqxmd.com/read/29888707/influence-of-key-processing-parameters-and-seeding-density-effects-of-microencapsulated-chondrocytes-fabricated-using-electrohydrodynamic-spraying
#6
Jennifer Gansau, Lara Kelly, Conor Buckley
Cell delivery and leakage during injection remains a challenge for cell-based intervertebral disc regeneration strategies. Cellular microencapsulation may offer a promising approach to overcome these limitations by providing a protective niche during intradiscal injection. Electrohydrodynamic spraying (EHDS) is a versatile one-step approach for microencapsulation of cells using a high voltage electric field. The primary objective of this work was to characterise key processing parameters such as applied voltage (0, 5, 10 or 15kV), emitter needle gauge (21, 26 or 30G), alginate concentration (1, 2 or 3%) and flow rate (50, 100, 250 or 500 µl/min) to regulate the morphology of alginate microcapsules and subsequent cell viability when altering these parameters...
June 11, 2018: Biofabrication
https://www.readbyqxmd.com/read/29886387/reactive-oxygen-species-scavenging-with-a-biodegradable-thermally-responsive-hydrogel-compatible-with-soft-tissue-injection
#7
Yang Zhu, Yasumoto Matsumura, Murugesan Velayutham, Lesley M Foley, T Kevin Hitchens, William R Wagner
Tissue damage and the impairment of regenerative processes by excessive reactive oxygen species (ROS) contributes to the pathogenesis of various diseases in soft tissues including diabetes, atherosclerosis, Parkinson's disease and myocardial ischemic/reperfusion injury. In this study, a thermally responsive injectable hydrogel poly(NIPAAm-co-VP-co-MAPLA-co-MATEMPO) (pNVMT, NIPAAm: N-isopropylacrylamide, VP: vinylpyrrolidone, MAPLA: methacrylate-polylactide, MATEMPO: methacrylate-TEMPO, TEMPO: 4-amino-TEMPO or 4-Amino-2,2,6,6-tetramethylpiperidine-1-oxyl) incorporating recyclable ROS scavenging nitroxide radicals on the polymer backbone was developed to locally control adverse tissue effects from free radical generation...
May 31, 2018: Biomaterials
https://www.readbyqxmd.com/read/29883809/additive-manufacturing-of-hierarchical-injectable-scaffolds-for-tissue-engineering
#8
A Béduer, N Piacentini, L Aeberli, A Da Silva, C A Verheyen, F Bonini, A Rochat, A Filippova, L Serex, P Renaud, T Braschler
We present a 3D-printing technology allowing free-form fabrication of centimetre-scale injectable structures for minimally invasive delivery. They result from the combination of 3D printing onto a cryogenic substrate and optimisation of carboxymethylcellulose-based cryogel inks. The resulting highly porous and elastic cryogels are biocompatible, and allow for protection of cell viability during compression for injection. Implanted into the murine subcutaneous space, they are colonized with a loose fibrovascular tissue with minimal signs of inflammation and remain encapsulation-free at three months...
June 5, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29882474/adipose-derived-stem-cells-in-a-resilient-in-situ-forming-hydrogel-modulate-macrophage-phenotype
#9
Stuart Young, Lauren Elizabeth Flynn, Brian G Amsden
Injectable hydrogels have the potential to enhance stem cell-based therapies by improving cell localization, retention, and survival following transplantation. The inflammatory response to both the hydrogel and the encapsulated cells is a critical aspect of this strategy, with macrophages being highly involved in the process of hydrogel remodelling, angiogenesis, and tissue regeneration. As a step towards the development of a cell-based strategy for therapeutic angiogenesis, the current work compared the intramuscular injection of allogeneic rat adipose-derived stem/stromal cells (rASCs) in an in situ-gelling hydrogel to the injection of the hydrogel alone and rASCs in saline in an immunocompetent rat model by immunohistochemical analysis over 4 weeks...
June 8, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29881402/simultaneous-delivery-of-wharton-s-jelly-mesenchymal-stem-cells-and-insulin-like-growth-factor-1-in-acute-myocardial-infarction
#10
Shahram Rabbani, Masoud Soleimani, Mohammad Sahebjam, Mohammad Imani, Azadeh Haeri, Ali Ghiaseddin, Seyed Mahdi Nassiri, Jalil Majd Ardakani, Maryam Tajik Rostami, Arash Jalali, Seyed Hossein Ahmadi Tafti
Wharton's jelly mesenchymal stem cells (HWJMSCs) hold promise for myocardial regeneration, but optimal treatment regimen (preferably with a growth factor) is required to maximize functional benefits. The aim of this study was to explore the cardioprotective and angiogenesis effects of HWJMSCs combined with insulin-like growth factor-1 (IGF-1) in the treatment of acute myocardial infarction. The hydrogel consisted of Polyethylene glycol (PEG) and hyaluronic acid was prepared and characterized with regards to rheology, morphology, swelling, degradation, and release behaviors...
2018: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/29876412/data-on-the-experiments-of-temperature-sensitive-hydrogels-for-ph-sensitive-drug-release-and-the-characterizations-of-materials
#11
Wei Zhang, Xin Jin, Heng Li, Run-Run Zhang, Cheng-Wei Wu
This article contains experimental data on the strain sweep, the calibration curve of drug (doxorubicin, DOX) and the characterizations of materials. Data included are related to the research article "Injectable and body temperature sensitive hydrogels based on chitosan and hyaluronic acid for pH sensitive drug release" (Zhang et al., 2017) [1]. The strain sweep experiments were performed on a rotational rheometer. The calibration curves were obtained by analyzing the absorbance of DOX solutions on a UV-vis-NIR spectrometer...
April 2018: Data in Brief
https://www.readbyqxmd.com/read/29873069/live-imaging-flow-bioreactor-for-the-simulation-of-articular-cartilage-regeneration-after-treatment-with-bioactive-hydrogel
#12
Assaf Bar, Emil Ruvinov, Smadar Cohen
Osteochondral defects (OCDs) are conditions affecting both cartilage and the underlying bone. Since cartilage is not spontaneously regenerated, our group has recently developed a strategy of injecting bioactive alginate hydrogel into the defect for promoting endogenous regeneration of cartilage via presentation of affinity-bound transforming growth factor β1 (TGF-β1). As in vivo model systems often provide only limited insights regarding the mechanism behind regeneration processes, here we describe a novel flow bioreactor for the in vitro modeling of the OCD microenvironment, designed to promote cell recruitment from the simulated bone marrow compartment into the hydrogel, under physiological flow conditions...
June 5, 2018: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29869613/novel-microgel-based-scaffolds-to-study-the-effect-of-degradability-on-human-dermal-fibroblasts
#13
Wenda Zhou, Jessica M Stukel, Abrar AlNiemi, Rebecca Kuntz Willits
For improved cell integration, tissue engineering scaffolds must be designed to degrade over time. Typically, the chemistry of scaffolds is modified to alter the degradation profile by using different hydrolytic or enzymatic sites within a material. It is more challenging, however, to fabricate self-assembling, injectable scaffolds that provide tunable degradation. Our laboratory has developed microgel-based scaffolds, where individual micron-sized hydrogels are crosslinked to make larger bulk scaffolds. The size of the individual microgels permits injection, and the microgels then self-assemble into a bulk structure and crosslink...
June 5, 2018: Biomedical Materials
https://www.readbyqxmd.com/read/29863957/incorporation-of-rosuvastatin-loaded-chitosan-chondroitin-sulfate-nanoparticles-into-a-thermosensitive-hydrogel-for-bone-tissue-engineering-preparation-characterization-and-cellular-behavior
#14
Mahboubeh Rezazadeh, Maryam Parandeh, Vajihe Akbari, Zahra Ebrahimi, Azade Taheri
Rosuvastatin (RSV) has been shown to have significant impact on the simulation of bone regeneration after local injection. The current study aimed to develop a localized controlled delivery system from RSV by incorporating RSV-loaded chitosan/chondroitin sulfate (CTS/CS) nanoparticles into thermosensitive Pluronic F127/hyaluronic acid (PF127/HA) hydrogel. RSV-loaded CTS/CS nanoparticles were prepared by ionic gelation and the impact of various formulation variables was assessed using the Box-Behnken design...
June 4, 2018: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/29861882/injectable-nanocurcumin-formulated-chitosan-g-pluronic-hydrogel-exhibiting-a-great-potential-for-burn-treatment
#15
Le Hang Dang, Thi Hiep Nguyen, Ha Le Bao Tran, Vu Nguyen Doan, Ngoc Quyen Tran
Burn wound healing is a complex multifactorial process that relies on coordinated signaling molecules to succeed. Curcumin is believed to be a potent antioxidant and anti-inflammatory agent; therefore, it can prevent the prolonged presence of oxygen free radicals which is a significant factor causing inhabitation of optimum healing process. This study describes an extension of study about the biofunctional nanocomposite hydrogel platform that was prepared by using curcumin and an amphiphilic chitosan-g-pluronic copolymer specialized in burn wound healing application...
2018: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/29861815/engineering-of-vascularized-3d-cell-constructs-to-model-cellular-interactions-through-a-vascular-network
#16
Emi Sano, Chihiro Mori, Yuji Nashimoto, Ryuji Yokokawa, Hidetoshi Kotera, Yu-Suke Torisawa
Current in vitro 3D culture models lack a vascular system to transport oxygen and nutrients, as well as cells, which is essential to maintain cellular viability and functions. Here, we describe a microfluidic method to generate a perfusable vascular network that can form inside 3D multicellular spheroids and functionally connect to microchannels. Multicellular spheroids containing endothelial cells and lung fibroblasts were embedded within a hydrogel inside a microchannel, and then, endothelial cells were seeded into both sides of the hydrogel so that angiogenic sprouts from the cell spheroids and the microchannels were anastomosed to form a 3D vascular network...
July 2018: Biomicrofluidics
https://www.readbyqxmd.com/read/29861090/assessment-of-in-vivo-degradation-profiles-of-hyaluronic-acid-hydrogels-using-temporal-evolution-of-chemical-exchange-saturation-transfer-cest-mri
#17
Mohammed Salman Shazeeb, Rubina Corazzini, Paul A Konowicz, Robert Fogle, Dinesh S Bangari, Jennifer Johnson, Xiaoyou Ying, Pradeep K Dhal
Hyaluronic acid (HA) hydrogels have found a wide range of applications in biomedicine: regenerative medicine to drug delivery applications. In vivo quantitative assessment of these hydrogels using magnetic resonance imaging (MRI) provides an effective, accurate, safe, and non-invasive translational approach to assess the biodegradability of HA hydrogels. Chemical exchange saturation transfer (CEST) is an MRI contrast enhancement technique that overcomes the concentration limitation of other techniques like magnetic resonance spectroscopy (MRS) by detecting metabolites at up to two orders of magnitude or higher...
May 23, 2018: Biomaterials
https://www.readbyqxmd.com/read/29858074/hydrogel-assisted-antisense-lna-gapmer-delivery-for-in-situ-gene-silencing-in-spinal-cord-injury
#18
Pedro M D Moreno, Ana R Ferreira, Daniela Salvador, Maria T Rodrigues, Marília Torrado, Eva D Carvalho, Ulf Tedebark, Mónica M Sousa, Isabel F Amaral, Jesper Wengel, Ana P Pêgo
After spinal cord injury (SCI), nerve regeneration is severely hampered due to the establishment of a highly inhibitory microenvironment at the injury site, through the contribution of multiple factors. The potential of antisense oligonucleotides (AONs) to modify gene expression at different levels, allowing the regulation of cell survival and cell function, together with the availability of chemically modified nucleic acids with favorable biopharmaceutical properties, make AONs an attractive tool for novel SCI therapy developments...
June 1, 2018: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/29845998/thermoresponsive-redox-polymerized-cellulosic-hydrogels-undergo-in-situ-gelation-and-restore-intervertebral-disc-biomechanics-post-discectomy
#19
D M Varma, H A Lin, R G Long, G T Gold, A C Hecht, J C Iatridis, S B Nicoll
Back and neck pain are commonly associated with intervertebral disc (IVD) degeneration. Structural augmentation of diseased nucleus pulposus (NP) tissue with biomaterials could restore degeneration-related IVD height loss and degraded biomechanical behaviors; however, effective NP replacement biomaterials are not commercially available. This study developed a novel, crosslinked, dual-polymer network (DPN) hydrogel comprised of methacrylated carboxymethylcellulose (CMC) and methylcellulose (MC), and used in vitro, in situ and in vivo testing to assess its efficacy as an injectable, in situ gelling, biocompatible material that matches native NP properties and restores IVD biomechanical behaviors...
May 30, 2018: European Cells & Materials
https://www.readbyqxmd.com/read/29845777/bioglass-activated-albumin-hydrogels-for-wound-healing
#20
Yanling Zhou, Long Gao, Jinliang Peng, Min Xing, Yan Han, Xiaoya Wang, Yuhong Xu, Jiang Chang
In this study, a novel Bioglass/albumin composite hydrogel with controllable injectability, good adhesiveness, and bioactivity, is developed by utilizing dual-functional bioactive ions released from Bioglass, which on one side controls the gelling time by creating an alkaline environment to regulate the cross-linking reaction between human serum albumin and succinimidyl succinate modified poly(ethylene glycol), and on the other side stimulates wound healing. The composite hydrogel exhibits adhesive property that is superior to clinically used fibrin and cyanoacrylate glues...
May 29, 2018: Advanced Healthcare Materials
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