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Injectable hydrogels

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https://www.readbyqxmd.com/read/29458102/%C3%AE-irradiated-chitosan-based-injectable-hydrogels-for-controlled-release-of-drug-montelukast-sodium
#1
Sadaf Hafeez, Atif Islam, Nafisa Gull, Abbas Ali, Shahzad Maqsood Khan, Saba Zia, Kalsoom Anwar, Saba Urooge Khan, Tahir Jamil
Novel pH-sensitive γ-irradiated low molecular weight chitosan (CS) (pre-irradiated) and poly (vinyl alcohol) (PVA) blended injectable hydrogels, crosslinked with varying concentrations of glycerol, were fabricated for drug delivery application. The effect of low molecular weight irradiated CS on controlled drug release was evaluated to address the problem of higher viscosity and lower solubility of high molecular weight CS. The FTIR spectra of hydrogels depicted the presence of all the incorporated functional groups and the developed interactions (physical and chemical)...
February 16, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29457597/injectable-collagen-rgd-systems-for-bone-tissue-engineering-applications
#2
Fu-Chen Kung
Imbalance crosslink density and polymer concentration gradient is formed within the traditional alginate hydrogel using calcium chloride as a crosslinking agent in external gelation for instantaneously process. In this studying, type I collagen (Col I) blended calcium salt form of poly(γ-glutamic acid) (γCaPGA) was mixing with RGD-modified alginate with convenient gelation process and suitable for practical use. The hydrophilicity of the resulting hydrogels was evaluated through swelling tests, water retention capacity tests, and water vapor permeation tests...
2018: Bio-medical Materials and Engineering
https://www.readbyqxmd.com/read/29457128/evaluation-of-hydrogels-presenting-extracellular-matrix-derived-adhesion-peptides-and-encapsulating-cardiac-progenitor-cells-for-cardiac-repair
#3
Srishti Bhutani, Aline L Y Nachlas, Milton E Brown, Tionne Pete, Christopher T Johnson, Andres J García, Michael E Davis
Cell therapy is an emerging paradigm for the treatment of heart disease. In spite of the exciting and promising preclinical results, the benefits of cell therapy for cardiac repair in patients have been modest at best. Biomaterials-based approaches may overcome the barriers of poor differentiation and retention of transplanted cells. In this study, we prepared and tested hydrogels presenting extracellular matrix (ECM)-derived adhesion peptides as delivery vehicles for c-kit+ cardiac progenitor cells (CPCs)...
January 8, 2018: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/29456012/injectable-and-body-temperature-sensitive-hydrogels-based-on-chitosan-and-hyaluronic-acid-for-ph-sensitive-drug-release
#4
Wei Zhang, Xin Jin, Heng Li, Run-Run Zhang, Cheng-Wei Wu
Hydrogels based on chitosan/hyaluronic acid/β-sodium glycerophosphate demonstrate injectability, body temperature sensitivity, pH sensitive drug release and adhesion to cancer cell. The drug (doxorubicin) loaded hydrogel precursor solutions are injectable and turn to hydrogels when the temperature is increased to body temperature. The acidic condition (pH 4.00) can trigger the release of drug and the cancer cell (Hela) can adhere to the surface of the hydrogels, which will be beneficial for tumor site-specific administration of drug...
April 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29456009/novel-in-situ-forming-hydrogel-based-on-xanthan-and-chitosan-re-gelifying-in-liquids-for-local-drug-delivery
#5
Jinjian Huang, Youming Deng, Jianan Ren, Guopu Chen, Gefei Wang, Feng Wang, Xiuwen Wu
Injectable hydrogels have been an attractive topic in biomaterials. However, during gelation in vivo, they are easy to disperse due to tissue exudates, thus leading to failure of controlled drug release. To solve this problem, we present a novel polysaccharide-based injectable hydrogel via self-crosslinking of aldehyde-modified xanthan (Xan-CHO) and carboxymethyl-modified chitosan (NOCC). The physical properties were optimized by adjusting the mass ratio of Xan-CHO and NOCC. Experiments revealed that this material exhibited the characteristics of self-healing, anti-enzymatic hydrolysis, biocompatibility and biodegradability...
April 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29455069/photo-crosslinkable-injectable-sericin-hydrogel-as-3d-biomimetic-extracellular-matrix-for-minimally-invasive-repairing-cartilage
#6
Chao Qi, Jia Liu, Yang Jin, Luming Xu, Guobin Wang, Zheng Wang, Lin Wang
Millions of patients worldwide suffer from cartilage injury and age/disease-related cartilage degeneration. However, cartilage, such as articular cartilage, is poor at self-regeneration. Current treatments are often invasive with limited efficacy. Developing minimal invasive strategies for effective cartilage repair is highly desired. Here, we report an injectable, photo-crosslinkable sericin hydrogel as a biomimetic extracellular matrix for minimal invasively repairing cartilage. Sericin was functionalized to be sericin methacryloyl (SerMA), which formed an in situ hydrogel upon UV light irradiation via photo-crosslinking...
February 9, 2018: Biomaterials
https://www.readbyqxmd.com/read/29454236/stingel-controlled-release-of-a-cyclic-dinucleotide-for-enhanced-cancer-immunotherapy
#7
David G Leach, Neeraja Dharmaraj, Stacey L Piotrowski, Tania L Lopez-Silva, Yu L Lei, Andrew G Sikora, Simon Young, Jeffrey D Hartgerink
Recent advancements in the field of immunotherapy have yielded encouraging results for the treatment of advanced cancers. Cyclic dinucleotides (CDNs) are a powerful new class of immunotherapy drugs known as STING (Stimulator of Interferon Genes) agonists, currently in clinical trials. However, previous studies of CDNs in murine cancer models have required multiple injections, and improve survival only in relatively nonaggressive tumor models. Therefore, we sought to improve the efficacy of CDN immunotherapy by developing a novel biomaterial we call "STINGel...
February 6, 2018: Biomaterials
https://www.readbyqxmd.com/read/29453807/tunable-poly-methacrylic-acid-co-acrylamide-nanoparticles-through-inverse-emulsion-polymerization
#8
Justin X Zhong, John R Clegg, Eric W Ander, Nicholas A Peppas
Environmentally responsive biomaterials have played key roles in the design of biosensors and drug delivery vehicles. Their physical response to external stimuli, such as temperature or pH, can transduce a signal or trigger the release of a drug. In this work, we designed a robust, highly tunable, pH responsive nanoscale hydrogel system. We present the design and characterization of poly((methacrylic acid) - co - acrylamide) hydrogel nanoparticles, crosslinked with methylenebisacrylamide, through inverse emulsion polymerization...
February 17, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29452185/an-injectable-chitosan-chondroitin-sulfate-hydrogel-with-tunable-mechanical-properties-for-cell-therapy-tissue-engineering
#9
Yasaman Alinejad, Atma Adoungotchodo, Eve Hui, Fatemeh Zehtabi, Sophie Lerouge
Chitosan (CH) hydrogels with remarkable mechanical properties and rapid gelation rate were recently synthesized by combining sodium hydrogen carbonate (SHC) with another weak base, such as beta-glycerophosphate (BGP). To improve their biological responses, in the present study, chondroitin sulfate (CS) was added to these CH hydrogels. Hydrogel characteristics in terms of pH and osmolarity as well as rheological, mechanical, morphological and swelling properties were studied in the absence and presence of CS...
February 13, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29451778/rapid-forming-and-self-healing-agarose-based-hydrogels-for-tissue-adhesives-and-potential-wound-dressings
#10
Zhuo Zhang, Xiaolin Wang, Yitong Wang, Jingcheng Hao
To meet the progressive requirements of advanced engineering materials with superior physicochemical performances, self-healing and injectable hydrogels (AD hydrogels) based on agarose with pH-response were prepared through dynamic covalent Schiff-base linkages by simply mixing nontoxic agarose-ethylenediamine conjugate (AG-NH2) and dialdehyde-functionalized polyethylene glycol (DF-PEG) solutions. The self-healing and injectable capabilities of the hydrogels without any external stimulus are ascribed to dynamic covalent Schiff-base linkages between the aldehyde groups of DF-PEG and amine groups on AG-NH2 backbone...
February 16, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29451033/control-release-of-mitochondria-targeted-antioxidant-by-injectable-self-assembling-peptide-hydrogel-ameliorated-persistent-mitochondrial-dysfunction-and-inflammation-after-acute-kidney-injury
#11
Meng Zhao, Yijie Zhou, Shuyun Liu, Lan Li, Younan Chen, Jingqiu Cheng, Yanrong Lu, Jingping Liu
Persistent mitochondrial injury occurs after acute kidney injury (AKI) and mitochondria-targeted antioxidant Mito-2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPO) (MT) has shown benefits for AKI, but its efficiency is limited by short half-life and side effect in vivo. Self-assembling peptide (SAP) hydrogel is a robust platform for drug delivery. This study aims to develop an SAP-based carrier to slow release MT for enhancing its long-term therapeutic potency on AKI. The KLD with aspartic acid (KLDD) was designed...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29449216/adjustable-delivery-of-pro-angiogenic-fgf-2-by-collagen-alginate-microspheres
#12
Zaheer Ali, Anik Islam, Peter Sherrell, Mark Le-Moine, Georgios Lolas, Konstantinos Syrigos, Mehrdad Rafat, Lasse D Jensen
Therapeutic induction of blood vessel growth (angiogenesis) in ischemic tissues holds great potential for treatment of myocardial infarction and stroke. Achieving sustained angiogenesis and vascular maturation has, however, been highly challenging. Here we demonstrate that collagen:alginate hydrogels containing therapeutic, pro-angiogenic FGF-2, and formulated as microspheres, is a promising and clinically relevant vehicle for therapeutic angiogenesis. By titrating the amount of readily dissolvable and degradable collagen with more slowly degradable alginate in the hydrogel mixture, the degradation rates of the biomaterial controlling the release kinetics of embedded pro-angiogenic FGF-2 can be adjusted...
February 15, 2018: Biology Open
https://www.readbyqxmd.com/read/29438883/gradient-nano-engineered-in-situ-forming-composite-hydrogel-for-osteochondral-regeneration
#13
Janani Radhakrishnan, Amrutha Manigandan, Prabu Chinnaswamy, Anuradha Subramanian, Swaminathan Sethuraman
Fabrication of anisotropic osteochondral-mimetic scaffold with mineralized subchondral zone and gradient interface remains challenging. We have developed an injectable semi-interpenetrating network hydrogel construct with chondroitin sulfate nanoparticles (ChS-NPs) and nanohydroxyapatite (nHA) (∼30-90 nm) in chondral and subchondral hydrogel zones respectively. Mineralized subchondral hydrogel exhibited significantly higher osteoblast proliferation and alkaline phosphatase activity (p < 0.05). Osteochondral hydrogel exhibited interconnected porous structure and spatial variation with gradient interface of nHA and ChS-NPs...
February 3, 2018: Biomaterials
https://www.readbyqxmd.com/read/29434200/sustained-micellar-delivery-via-inducible-transitions-in-nanostructure-morphology
#14
Nicholas B Karabin, Sean Allen, Ha-Kyung Kwon, Sharan Bobbala, Emre Firlar, Tolou Shokuhfar, Kenneth R Shull, Evan A Scott
Nanocarrier administration has primarily been restricted to intermittent bolus injections with limited available options for sustained delivery in vivo. Here, we demonstrate that cylinder-to-sphere transitions of self-assembled filomicelle (FM) scaffolds can be employed for sustained delivery of monodisperse micellar nanocarriers with improved bioresorptive capacity and modularity for customization. Modular assembly of FMs from diverse block copolymer (BCP) chemistries allows in situ gelation into hydrogel scaffolds following subcutaneous injection into mice...
February 12, 2018: Nature Communications
https://www.readbyqxmd.com/read/29425720/nanoengineered-injectable-hydrogels-from-kappa-carrageenan-and-two-dimensional-nanosilicates-for-wound-healing-application
#15
Giriraj Lokhande, James K Carrow, Teena Thakur, Janet R Xavier, Madasamy Parani, Kayla J Bayless, Akhilesh K Gaharwar
We report injectable nanoengineered hemostats for enhanced wound healing and tissue regeneration. The nanoengineered system consists of the natural polysaccharide, κ-carrageenan (κCA), loaded with bioactive two-dimensional (2D) nanosilicates. Nanoengineered hydrogels showed shear-thinning characteristics and can be injected for a minimally invasive approach. The hydrogel can be physically crosslinked in presence of monovalent ions and result in mechanically strong hydrogels. By controlling the ratio between κCA and nanosilicates, compressive stiffness of nanoengineered hydrogels can be modulated between 20 to 200kPa...
February 6, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29423489/a-ph-and-temperature-responsive-bioresorbable-injectable-hydrogel-based-on-polypeptide-block-copolymers-for-the-sustained-delivery-of-proteins-in-vivo
#16
Md Hasan Turabee, Thavasyappan Thambi, Huu Thuy Trang Duong, Ji Hoon Jeong, Doo Sung Lee
Sustained delivery of protein therapeutics is limited owing to the fragile nature of proteins. Despite its great potential, delivery of proteins without any loss of bioactivity remains a challenge in the use of protein therapeutics in the clinic. To surmount this shortcoming, we report a pH- and temperature-responsive in situ-forming injectable hydrogel based on comb-type polypeptide block copolymers for the controlled delivery of proteins. Polypeptide block copolymers, composed of hydrophilic polyethylene glycol (PEG), temperature-responsive poly(γ-benzyl-l-glutamate) (PBLG), and pH-responsive oligo(sulfamethazine) (OSM), exhibit pH- and temperature-induced sol-to-gel transition behavior in aqueous solutions...
February 9, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29417934/functionalized-thermosensitive-hydrogel-combined-with-tendon-stem-progenitor-cells-as-injectable-cell-delivery-carrier-for-tendon-tissue-engineering
#17
Heyong Yin, Zexing Yan, Richard Bauer, Jiang Peng, Matthias Schieker, Michael Nerlich, Denitsa Docheva
Thermosensitive hydrogels have been studied for potential application as promising alternative cell carriers in cell-based regenerative therapies. In this study, a thermosensitive butane diisocyanate (BDI)-collagen hydrogel (BC hydrogel) was designed as injectable cell delivery carrier of tendon stem/progenitor cells (TSPCs) for tendon tissue engineering. We functionalized the BDI hydrogel with the addition of 20% (v/v) collagen I gel to obtain the thermosensitive BC hydrogel, which was then seeded with TSPCs derived from human Achilles tendons...
February 8, 2018: Biomedical Materials
https://www.readbyqxmd.com/read/29417640/dynamic-protein-metal-ion-networks-a-unique-approach-to-injectable-and-self-healable-metal-sulfide-protein-hybrid-hydrogels-with-high-photothermal-efficiency
#18
Liqiang Wang, Kaixin Liang, Xingxing Jiang, Minghui Yang, You-Nian Liu
A new strategy is proposed to fabricate adaptable protein-based hydrogel networks with both injectable and self-healable properties. By mixing proteins and metal ions under alkaline conditions, the metal ions can crosslink proteins into protein-metal ion dynamic networks. Subsequently, the metal ions can react with the cysteine residues of protein to in situ form corresponding metal sulfide NPs with ultra-small size, which leads to hybrid hydrogels with adaptable structures. This approach is general and a series of metal sulfide NP in situ embedded nanocompoiste hydrogels were obtained...
February 8, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29409316/an-injectable-hexapeptide-hydrogel-for-localized-chemotherapy-prevents-breast-cancer-recurrence
#19
Yingqiu Qi, Huan Min, Ayeesha Mujeeb, Yinlong Zhang, Xuexiang Han, Xiao Zhao, Greg J Anderson, Ying Zhao, Guangjun Nie
Although post-surgical chemotherapy is frequently used for the treatment of breast cancer, tumor recurrence is still a frequent event. Enhancing the efficacy of chemotherapy via localized drug delivery may help to prevent breast cancer recurrence. To achieve this goal, we designed a hydrogel nanocarrier that could be injected at tumor site by co-assembly of tailor-made hexapeptide and doxorubicin (Dox). Evidently based on our findings, the sustained release of drug from the hydrogel led to a reduction in cancer recurrence, including the suppression of primary regrowth and distant metastasis...
February 7, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29406542/protein-engineered-hydrogels-enhance-the-survival-of-induced-pluripotent-stem-cell-derived-endothelial-cells-for-treatment-of-peripheral-arterial-disease
#20
Abbygail A Foster, Ruby E Dewi, Lei Cai, Luqia Hou, Zachary Strassberg, Cynthia A Alcazar, Sarah C Heilshorn, Ngan F Huang
A key feature of peripheral arterial disease (PAD) is damage to endothelial cells (ECs), resulting in lower limb pain and restricted blood flow. Recent preclinical studies demonstrate that the transplantation of ECs via direct injection into the affected limb can result in significantly improved blood circulation. Unfortunately, the clinical application of this therapy has been limited by low cell viability and poor cell function. To address these limitations we have developed an injectable, recombinant hydrogel, termed SHIELD (Shear-thinning Hydrogel for Injectable Encapsulation and Long-term Delivery) for cell transplantation...
February 6, 2018: Biomaterials Science
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