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Injectable hydrogels

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https://www.readbyqxmd.com/read/27918129/photo-modulated-therapeutic-protein-release-from-a-hydrogel-depot-using-visible-light
#1
Johan S Basuki, Fengxiang Qie, Xavier Mulet, Randy Suryadinata, Aditya V Vashi, Yong Y Peng, Lingli Li, Xiaojuan Hao, Tianwei Tan, Timothy C Hughes
The use of biomacromolecular therapeutics has revolutionized disease treatment, but frequent injections are required owing to their short half-life in vivo. Thus there is a need for a drug delivery system that acts as a reservoir and releases the drug remotely "on demand". Here we demonstrate a simple light-triggered local drug delivery system through photo-thermal interactions of polymer-coated gold nanoparticles (AuNPs) inside an agarose hydrogel as therapeutic depot. Localized temperature increase induced by the visible light exposure caused reversible softening of the hydrogel matrix to release the pre-loaded therapeutics...
December 5, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27915024/extracellular-matrix-hydrogels-from-decellularized-tissues-structure-and-function
#2
REVIEW
Lindsey T Saldin, Madeline C Cramer, Sachin S Velankar, Lisa J White, Stephen F Badylak
: Extracellular matrix (ECM) bioscaffolds prepared from decellularized tissues have been used to facilitate constructive and functional tissue remodeling in a variety of clinical applications. The discovery that these ECM materials could be solubilized and subsequently manipulated to form hydrogels expanded their potential in vitro and in vivo utility; i.e. as culture substrates comparable to collagen or Matrigel, and as injectable materials that fill irregularly-shaped defects. The mechanisms by which ECM hydrogels direct cell behavior and influence remodeling outcomes are only partially understood, but likely include structural and biological signals retained from the native source tissue...
November 30, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27915016/injectable-supramolecular-hydrogel-formed-from-%C3%AE-cyclodextrin-and-peglated-arginine-functionalized-poly-l-lysine-dendron-for-sustained-mmp-9-shrna-plasmid-delivery
#3
Qianming Lin, Yumeng Yang, Qian Hu, Zhong Guo, Tao Liu, Jiake Xu, Jianping Wu, Thomas Brett Kirk, Dong Ma, Wei Xue
: Hydrogels have attracted much attention in cancer therapy and tissue engineering due to their sustained gene delivery ability. To obtain an injectable and high-efficiency gene delivery hydrogel, methoxypolyethylene glycol (MPEG) was used to conjugate with the arginine-functionalized poly(L-lysine) dendron (PLLD-Arg) by click reaction, and then the synthesized MPEG-PLLD-Arg interacted with α-cyclodextrin (α-CD) to form the supramolecular hydrogel by the host-guest interaction. The gelation dynamics, hydrogel strength and shear viscosity could be modulated by α-CD content in the hydrogel...
November 30, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27911849/scalable-manufacturing-of-biomimetic-moldable-hydrogels-for-industrial-applications
#4
Anthony C Yu, Haoxuan Chen, Doreen Chan, Gillie Agmon, Lyndsay M Stapleton, Alex M Sevit, Mark W Tibbitt, Jesse D Acosta, Tony Zhang, Paul W Franzia, Robert Langer, Eric A Appel
Hydrogels are a class of soft material that is exploited in many, often completely disparate, industrial applications, on account of their unique and tunable properties. Advances in soft material design are yielding next-generation moldable hydrogels that address engineering criteria in several industrial settings such as complex viscosity modifiers, hydraulic or injection fluids, and sprayable carriers. Industrial implementation of these viscoelastic materials requires extreme volumes of material, upwards of several hundred million gallons per year...
November 28, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27903455/complexation-hydrogels-as-potential-carriers-in-oral-vaccine-delivery-systems
#5
Mia Yoshida, Noriyasu Kamei, Keiya Muto, Jun Kunisawa, Kozo Takayama, Nicholas A Peppas, Mariko Takeda-Morishita
Most current vaccine preparations are in injectable forms, which are inconvenient to patients and ineffective in mucosal immunization. Therefore, most research in this field has been directed at developing ideal oral vaccines enabling the induction of both systemic and mucosal immune responses. In the present study, we examined the utility of a pH-responsive polymeric carrier, poly (methacrylic acid-g-ethylene glycol) [P (MAA-g-EG)] hydrogel, as a potential oral vaccine carrier that can protect cargo proteins in the gastrointestinal tract...
November 26, 2016: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/27903402/-research-progress-on-the-efficacy-and-feasibility-of-injectable-hydrogels-for-the-clinical-treatment-of-myocardial-infarction
#6
(no author information available yet)
No abstract text is available yet for this article.
November 24, 2016: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/27901092/a-microfluidic-platform-to-design-crosslinked-hyaluronic-acid-nanoparticles-chanps-for-enhanced-mri
#7
Maria Russo, Paolo Bevilacqua, Paolo Antonio Netti, Enza Torino
Recent advancements in imaging diagnostics have focused on the use of nanostructures that entrap Magnetic Resonance Imaging (MRI) Contrast Agents (CAs), without the need to chemically modify the clinically approved compounds. Nevertheless, the exploitation of microfluidic platforms for their controlled and continuous production is still missing. Here, a microfluidic platform is used to synthesize crosslinked Hyaluronic Acid NanoParticles (cHANPs) in which a clinically relevant MRI-CAs, gadolinium diethylenetriamine penta-acetic acid (Gd-DTPA), is entrapped...
November 30, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27897217/self-healing-polysaccharide-based-hydrogels-as-injectable-carriers-for-neural-stem-cells
#8
Zhao Wei, Jingyi Zhao, Yong Mei Chen, Pengbo Zhang, Qiqing Zhang
Self-healing injectable hydrogels can be formulated as three-dimensional carriers for the treatment of neurological diseases with desirable advantages, such as avoiding the potential risks of cell loss during injection, protecting cells from the shearing force of injection. However, the demands for biocompatible self-healing injectable hydrogels to meet above requirements and to promote the differentiation of neural stem cells (NSCs) into neurons remain a challenge. Herein, we developed a biocompatible self-healing polysaccharide-based hydrogel system as a novel injectable carrier for the delivery of NSCs...
November 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27893850/a-convenient-in-vivo-model-using-small-interfering-rna-silencing-to-rapidly-assess-skeletal-gene-function
#9
Wen Zhang, Can Liu, Bao Hai, Guohong Du, Hong Wang, Huijie Leng, Yingsheng Xu, Chunli Song
It is difficult to study bone in vitro because it contains various cell types that engage in cross-talk. Bone biologically links various organs, and it has thus become increasingly evident that skeletal physiology must be studied in an integrative manner in an intact animal. We developed a model using local intraosseous small interfering RNA (siRNA) injection to rapidly assess the effects of a target gene on the local skeletal environment. In this model, 160-g male Sprague-Dawley rats were treated for 1-2 weeks...
2016: PloS One
https://www.readbyqxmd.com/read/27892654/injectable-polysaccharide-hydrogels-as-biocompatible-platforms-for-localized-and-sustained-delivery-of-antibiotics-for-preventing-local-infections
#10
Ziyi Li, Chaoliang He, Baoming Yuan, Xiaoming Dong, Xuesi Chen
Biocompatible and antibacterial hydrogels have received increasing attention for preventing local bacterial infections. In this study, a type of polysaccharide hydrogels is prepared via the Schiff-based reaction at physiological conditions. The gelation time and mechanical property of the hydrogels are found to be dependent on the polysaccharide concentration and the polysaccharide weight ratio. 3-(4,5-Dimethyl-thiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay and live/dead assay indicate that the hydrogels display nontoxicity in vitro...
November 28, 2016: Macromolecular Bioscience
https://www.readbyqxmd.com/read/27890826/relevant-variations-and-neuroprotecive-effect-of-hydrogen-sulfide-in-a-rat-glaucoma-model
#11
Shouyue Huang, Ping Huang, Xiaohong Liu, Zhongjing Lin, Jing Wang, Shuo Xu, Lei Guo, Christopher Kai-Shun Leung, Yisheng Zhong
Glaucoma is an irreversible and blinding neurodegenerative disease of the eye, and is characterized by progressive loss of retinal ganglion cells (RGCs). Since endogenous hydrogen sulfide (H2S) was reported to be involved in neurodegeneration in the central nervous system, the authors aimed to develop a chronic ocular hypertension (COH) rat model simulating glaucoma and therein test the H2S level together with the retinal protein expressions of related synthases, and further investigated the effect of exogenous H2S supplement on RGC survival...
November 24, 2016: Neuroscience
https://www.readbyqxmd.com/read/27888253/thermo-sensitive-hydrogel-plga-peg-plga-as-a-vaccine-delivery-system-for-intramuscular-immunization
#12
Xiaoyan Wang, Yu Zhang, Wei Xue, Hong Wang, Xiaozhong Qiu, Zonghua Liu
In this work, we explored the potential of thermo-sensitive PLGA-PEG-PLGA with sol-gel transition temperature around 32℃ as an intramuscular vaccine delivery system by using ovalbumin as a model antigen. First, in vitro release test showed that the PLGA-PEG-PLGA-deriving hydrogels could release ovalbumin in vitro in a more sustainable way. From fluorescence living imaging, 50-200 mg/mL of PLGA-PEG-PLGA formulations could release antigen in a sustainable manner in vivo, suggesting that the PLGA-PEG-PLGA hydrogel worked as an antigen-depot...
November 25, 2016: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/27886554/a-biomaterial-assisted-mesenchymal-stromal-cell-therapy-alleviates-colonic-radiation-induced-damage
#13
Lara Moussa, Girish Pattappa, Bastien Doix, Sarra-Louiza Benselama, Christelle Demarquay, Marc Benderitter, Alexandra Sémont, Radia Tamarat, Jérôme Guicheux, Pierre Weiss, Gildas Réthoré, Noëlle Mathieu
Healthy tissues surrounding abdomino-pelvic tumours can be impaired by radiotherapy, leading to chronic gastrointestinal complications with substantial mortality. Adipose-derived Mesenchymal Stromal Cells (Ad-MSCs) represent a promising strategy to reduce intestinal lesions. However, systemic administration of Ad-MSCs results in low cell engraftment within the injured tissue. Biomaterials, able to encapsulate and withstand Ad-MSCs, can overcome these limitations. A silanized hydroxypropylmethyl cellulose (Si-HPMC) hydrogel has been designed and characterized for injectable cell delivery using the operative catheter of a colonoscope...
November 16, 2016: Biomaterials
https://www.readbyqxmd.com/read/27884715/improved-sustained-release-of-antigen-from-immunostimulatory-dna-hydrogel-by-electrostatic-interaction-with-chitosan
#14
Yumiko Ishii-Mizuno, Yuka Umeki, Yoshinori Onuki, Hiroshi Watanabe, Yuki Takahashi, Yoshinobu Takakura, Makiya Nishikawa
Immunostimulatory DNA hydrogel (sDNA hydrogel) containing unmethylated cytosine-phosphate-guanine (CpG) sequences has been demonstrated to be a useful antigen delivery system, which can effectively induce an antigen-specific immune response through stimulation of the innate immune system. However, relatively rapid release of antigens from the sDNA hydrogel limits its potential. To enhance the potency of the sDNA hydrogel via improvement of its sustained release property, we selected chitosan, a biocompatible cationic polymer which electrostatically interacts with DNA, and mixed it with the sDNA hydrogel...
November 21, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27879635/a-review-of-injectable-polymeric-hydrogel-systems-for-application-in-bone-tissue-engineering
#15
REVIEW
Pariksha J Kondiah, Yahya E Choonara, Pierre P D Kondiah, Thashree Marimuthu, Pradeep Kumar, Lisa C du Toit, Viness Pillay
Biodegradable, stimuli-responsive polymers are essential platforms in the field of drug delivery and injectable biomaterials for application of bone tissue engineering. Various thermo-responsive hydrogels display water-based homogenous properties to encapsulate, manipulate and transfer its contents to the surrounding tissue, in the least invasive manner. The success of bioengineered injectable tissue modified delivery systems depends significantly on their chemical, physical and biological properties. Irrespective of shape and defect geometry, injectable therapy has an unparalleled advantage in which intricate therapy sites can be effortlessly targeted with minimally invasive procedures...
November 21, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27872015/self-hardening-and-thermoresponsive-alpha-tricalcium-phosphate-pluronic-pastes
#16
Yassine Maazouz, Edgar B Montufar, Julien Malbert, Montserrat Espanol, Maria-Pau Ginebra
: Although calcium phosphate cements (CPCs) are used for bone regeneration in a wide range of clinical applications, various physicochemical phenomena are known to hinder their potential use in minimally invasive surgery or in highly vascularized surgical sites, mainly because of their lack of injectability or their low washout resistance. The present work shows that the combination of CPCs with an inverse-thermoresponsive hydrogel is a good strategy for finely tuning the cohesive and rheological properties of CPCs to achieve clinical acceptable injectability to prevent phase separation during implantation and cohesion to avoid washout of the paste...
November 18, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27869192/peritoneal-adhesion-prevention-with-a-biodegradable-and-injectable-n-o-carboxymethyl-chitosan-aldehyde-hyaluronic-acid-hydrogel-in-a-rat-repeated-injury-model
#17
Linjiang Song, Ling Li, Tao He, Ning Wang, Suleixin Yang, Xi Yang, Yan Zeng, Wenli Zhang, Li Yang, Qinjie Wu, Changyang Gong
Postoperative peritoneal adhesion is one of the serious issues because it induces severe clinical disorders. In this study, we prepared biodegradable and injectable hydrogel composed of N,O-carboxymethyl chitosan (NOCC) and aldehyde hyaluronic acid (AHA), and assessed its anti-adhesion effect in a rigorous and severe recurrent adhesion model which is closer to clinical conditions. The flexible hydrogel, which gelated in 66 seconds at 37 °C, was cross-linked by the schiff base derived from the amino groups of NOCC and aldehyde groups in AHA...
November 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27869102/novel-injectable-self-gelling-hydrogel-microparticle-composites-for-bone-regeneration-consisting-of-gellan-gum-and-calcium-and-magnesium-carbonate-microparticles
#18
Timothy E L Douglas, Agata Łapa, Katarzyna Reczyńska, Małgorzata Krok-Borkowicz, Krzysztof Pietryga, Sangram Keshari Samal, Heidi A Declercq, David Schaubroeck, Marijn Boone, Pascal Van der Voort, Karel De Schamphelaere, Christian V Stevens, Vitaliy Bliznuk, Lieve Balcaen, Bogdan V Parakhonskiy, Frank Vanhaecke, Veerle Cnudde, Elżbieta Pamuła, Andre G Skirtach
The suitability of hydrogel biomaterials for bone regeneration can be improved by incorporation of an inorganic phase in particle form, thus maintaining hydrogel injectability. In this study, carbonate microparticles containing different amounts of calcium (Ca) and magnesium (Mg) were added to solutions of the anionic polysaccharide gellan gum (GG) to crosslink GG by release of Ca(2+) and Mg(2+) from microparticles and thereby induce formation of hydrogel-microparticle composites. It was hypothesized that increasing Mg content of microparticles would promote GG hydrogel formation...
November 21, 2016: Biomedical Materials
https://www.readbyqxmd.com/read/27865962/pharmacologically-active-microcarriers-delivering-bdnf-within-a-hydrogel-novel-strategy-for-human-bone-marrow-derived-stem-cells-neural-neuronal-differentiation-guidance-and-therapeutic-secretome-enhancement
#19
Saikrishna Kandalam, Laurence Sindji, Gaëtan J-R Delcroix, Fabien Violet, Xavier Garric, Emilie M André, Paul C Schiller, Marie-Claire Venier-Julienne, Anne des Rieux, Jérôme Guicheux, Claudia N Montero-Menei
: Stem cells combined with biodegradable injectable scaffolds releasing growth factors hold great promises in regenerative medicine, particularly in the treatment of neurological disorders. We here integrated human marrow-isolated adult multilineage-inducible (MIAMI) stem cells and pharmacologically active microcarriers (PAMs) into an injectable non-toxic silanized-hydroxypropyl methylcellulose (Si-HPMC) hydrogel. The goal is to obtain an injectable non-toxic cell and growth factor delivery device...
November 16, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27863665/biodegradable-hydrophilic-carriers-for-the-oral-delivery-of-hematological-factor-ix-for-hemophilia-b-treatment
#20
Sarena D Horava, Katie J Moy, Nicholas A Peppas
Current protein replacement therapies for hemophilia B, a genetic bleeding disorder caused by a deficiency in coagulation factor IX, rely on IV injections and infusions. Oral delivery of factor IX is a desirable needle-free option, especially for prophylaxis. We have developed a biodegradable, pH-responsive hydrogel microcarrier system based on the poly(methacrylic acid)-grafted-poly(ethylene glycol) [P(MAA-g-EG)]. Incorporation of an enzymatically degradable peptide crosslinking agent allows for site-specific degradation by trypsin in the small intestine...
November 30, 2016: International Journal of Pharmaceutics
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