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Injectable hydrogels

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https://www.readbyqxmd.com/read/28210793/a-national-population-based-cohort-study-of-urethral-injection-therapy-for-female-stress-and-mixed-urinary-incontinence-the-danish-urogynaecological-database-2007-2011
#1
Margrethe Foss Hansen, Gunnar Lose, Ulrik Schiøler Kesmodel, Kim Oren Gradel
INTRODUCTION AND HYPOTHESIS: Urethral injection therapy (UIT) has been performed since the early 20th century and a variety of agents have been launched. In 2006, polyacrylamide hydrogel (PAGH) was introduced and is now widely used as an agent. The objective was to evaluate the efficacy of PAGH based on a national population over a 5-year period (2007-2011) and the influence of patient-related factors, surgeon experience, and department volume. METHODS: A retrospective cohort study was carried out based on data from the Danish Urogynaecological Database (DugaBase)...
February 16, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28209525/stromal-vascular-fraction-shows-robust-wound-healing-through-high-chemotactic-and-epithelialization-property
#2
Dong-Sic Chae, Seongho Han, Mina Son, Sung-Whan Kim
BACKGROUND: Although human stromal vascular fraction (SVF) has been regarded as an attractive stem cell source, its therapeutic mechanism in wound healing has not been fully elucidated. AIMS: In this study, we investigated the molecular characteristics and therapeutic property of SVF for wound healing. METHODS: Microarray data showed that SVF cells are enriched with a higher level of wound healing or epithelium development-related genes and micro RNA...
February 13, 2017: Cytotherapy
https://www.readbyqxmd.com/read/28207269/a-biocompatible-injectable-hydrogel-with-potent-wound-healing-and-antibacterial-properties
#3
Jiaul Hoque, Relekar G Prakash, Krishnamoorthy Paramanandham, Bibek R Shome, Jayanta Haldar
Two component injectable hydrogels that cross-link in-situ have been used as non-invasive wound-filling devices, i.e., sealants. These materials carry a variety of functions at the wound sites such as seal leaks, cease unwanted bleeding, bind tissues together, and assist in wound healing process. However, commonly used sealants typically lack antibacterial properties. Since bacterial infection at the wound site is very common, bioadhesive materials with intrinsic antibacterial properties are urgently required...
February 16, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28194646/nanoemulsion-thermoreversible-pluronic-f127-based-hydrogel-containing-hyptis-pectinata-lamiaceae-leaf-essential-oil-produced-a-lasting-anti-hyperalgesic-effect-in-chronic-noninflammatory-widespread-pain-in-mice
#4
Lucindo J Quintans-Júnior, Renan G Brito, Jullyana S S Quintans, Priscila L Santos, Zaine T Camargo, Péricles A Barreto, Maria F Arrigoni-Blank, Waldecy Lucca-Júnior, Luciana Scotti, Marcus T Scotti, Sandra J Kolker, Kathleen A Sluka
We evaluated if a nanostructured thermoreversible Pluronic F127-based hydrogel incorporated with Hyptis pectinata leaf essential oil (NE-EOH) produces a long-lasting anti-hyperalgesic effect on chronic muscle pain in an animal model. We induced chronic muscle pain by injecting the gastrocnemius with saline injections. Paw and muscle withdrawal thresholds and motor performance were evaluated after treatment and compared with morphine, diazepam, or vehicle. Naloxone and methysergide administration tested the involvement of opioid and serotonin receptors, respectively...
February 13, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28193542/sulfated-hyaluronic-acid-hydrogels-with-retarded-degradation-and-enhanced-growth-factor-retention-promote-hmsc-chondrogenesis-and-articular-cartilage-integrity-with-reduced-hypertrophy
#5
Qian Feng, Sien Lin, Kunyu Zhang, Chaoqun Dong, Tianyi Wu, Heqin Huang, Xiaohui Yan, Li Zhang, Gang Li, Liming Bian
: Recently, hyaluronic acid (HA) hydrogels have been extensively researched for delivering cells and drugs to repair damaged tissues, particularly articular cartilage. However, the in vivo degradation of HA is fast, thus limiting the clinical translation of HA hydrogels. Furthermore, HA cannot bind proteins with high affinity because of the lack of negatively charged sulfate groups. In this study, we conjugated sulfate groups to HA. These sulfated HA exhibit significantly slower degradation by hyaluronidase compared to the wild type HA...
February 10, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28193537/preparation-characterization-and-in-vivo-evaluation-of-a-combination-delivery-system-based-on-hyaluronic-acid-jeffamine-hydrogel-loaded-with-phbv-plga-blend-nanoparticles-for-prolonged-delivery-of-teriparatide
#6
Nika Bahari Javan, Hamed Montazeri, Leila Rezaie Shirmard, Nersi Jafary Omid, Ghullam Reza Barbari, Mohsen Amini, Mohammad Hossein Ghahremani, Morteza Rafiee-Tehrani, Farid Abedin Dorkoosh
In the current study, biodegradable PHBV/PLGA blend nanoparticles (NPs) containing Teriparatide were loaded in hyaluronic acid/jeffamine (HA-JEF ED-600) hydrogel to prepare a combination delivery system (CDS) for prolonged delivery of Teriparatide. The principal purpose of the present study was to formulate an effective and prolonged Teriparatide delivery system in order to reduce the frequency of injection and thus enhance patient's compliance. Morphological properties, swelling behaviour, crosslinking efficiency and rheological characterization of HA-JEF ED-600 hydrogel were evaluated...
February 10, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28192660/in-vivo-imaging-of-the-stability-and-sustained-cargo-release-of-an-injectable-amphipathic-peptide-based-hydrogel
#7
Edith Oyen, Charlotte Martin, Vicky Caveliers, Annemieke Madder, Bruno Van Mele, Richard Hoogenboom, Sophie Hernot, Steven Ballet
Hydrogels are promising materials for biomedical applications such as tissue engineering and controlled drug release. In the past two decades, the peptide hydrogel subclass has attracted an increasing level of interest from the scientific community because of its numerous advantages, such as biocompatibility, biodegradability, and, most importantly, injectability. Here, we report on a hydrogel consisting of the amphipathic hexapeptide H-FEFQFK-NH2, which has previously shown promising in vivo properties in terms of releasing morphine...
February 20, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28186167/in-vivo-pharmacological-evaluations-of-pilocarpine-loaded-antioxidant-functionalized-biodegradable-thermogels-in-glaucomatous-rabbits
#8
Shih-Feng Chou, Li-Jyuan Luo, Jui-Yang Lai
To alleviate oxidative stress-induced ocular hypertension, grafting of antioxidant molecules to drug carriers enables a dual-function mechanism to effectively treat glaucomatous intraocular pressure (IOP) dysregulation. Providing potential application for intracameral administration of antiglaucoma medications, this study, for the first time, aims to examine in vivo pharmacological efficacy of pilocarpine-loaded antioxidant-functionalized biodegradable thermogels in glaucomatous rabbits. A series of gallic acid (GA)-grafted gelatin-g-poly(N-isopropylacrylamide) (GN) polymers were synthesized via redox reactions at 20-50 °C...
February 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28184404/supramolecular-hydrogel-based-on-high-solid-content-mpect-nanoparticles-and-cyclodextrins-for-local-and-sustained-drug-delivery
#9
Li Yin, Shuxin Xu, Zujian Feng, Hongzhang Deng, Jianhua Zhang, Huijie Gao, Liandong Deng, Hua Tang, Anjie Dong
A novel injectable and high-solid-content drug-loaded supramolecular hydrogel (PTX-mPECT NP/α-CD(gel)) was prepared by self-assembly of inclusion complexes based on PTX-loaded mPECT (methoxy poly(ethylene glycol)-b-poly(ε-caprolactone-co-1,4,8-trioxa[4.6]spiro-9-un-decanone)) nanoparticles (PTX-mPECT NPs) and α-cyclodextrin (α-CD). Paclitaxel (PTX) was chosen as a hydrophobic drug encapsulated into mPECT NPs. Then, gelation occurred when the aqueous solution of α-CD was added to the PTX-mPECT NPs aqueous dispersion within several seconds after stirring...
February 10, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28183600/injectable-dextran-hydrogels-fabricated-by-metal-free-click-chemistry-for-cartilage-tissue-engineering
#10
Xiaoyu Wang, Zihan Li, Ting Shi, Peng Zhao, Kangkang An, Chao Lin, Hongwei Liu
Injectable dextran-based hydrogels were prepared for the first time by bioorthogonal click chemistry for cartilage tissue engineering. Click-crosslinked injectable hydrogels based on cyto-compatible dextran (Mw=10kDa) were successfully fabricated under physiological conditions by metal-free alkyne-azide cycloaddition (click) reaction between azadibenzocyclooctyne-modified dextran (Dex-ADIBO) and azide-modified dextran (Dex-N3). Gelation time of these dextran hydrogels could be regulated in the range of approximately 1...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28181835/irinotecan-encapsulated-double-reverse-thermosensitive-nanocarrier-system-for-rectal-administration
#11
Fakhar Ud Din, Ju Yeon Choi, Dong Wuk Kim, Omer Mustapha, Dong Shik Kim, Raj Kumar Thapa, Sae Kwang Ku, Yu Seok Youn, Kyung Taek Oh, Chul Soon Yong, Jong Oh Kim, Han-Gon Choi
Intravenously administered for the treatment of rectum cancer, irinotecan produces severe side effects due to very high plasma concentrations. A novel irinotecan-encapsulated double reverse thermosensitive nanocarrier system (DRTN) for rectal administration was developed as an alternative. The DRTN was fabricated by dispersing the thermosensitive irinotecan-encapsulated solid lipid nanoparticles (SLN) in the thermosensitive poloxamer solution. Its gel properties, pharmacokinetics, morphology, anticancer activity and immunohistopathology were assessed after its rectal administration to rats and tumor-bearing mice...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28165664/hydrogel-derived-from-decellularized-porcine-adipose-tissue-as-a-promising-biomaterial-for-soft-tissue-augmentation
#12
Qiu-Wen Tan, Yi Zhang, Jing-Cong Luo, Di Zhang, Bin-Jun Xiong, Ji-Qiao Yang, Hui-Qi Xie, Qing Lv
Decellularized extracellular matrix (ECM) scaffolds from human adipose tissue, characterized by impressive adipogenic induction ability, are promising for soft tissue augmentation. However, scaffolds from autologous human adipose tissue are limited by the availability of tissue resources and the time necessary for scaffold fabrication. The objective of the current study was to investigate the adipogenic properties of hydrogels of decellularized porcine adipose tissue (HDPA). HDPA induced the adipogenic differentiation of human adipose-derived stem cells (ADSCs) in vitro, with significantly increased expression of adipogenic genes...
February 6, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28151562/cation-tuning-of-supramolecular-gel-properties-a-new-paradigm-for-sustained-drug-delivery
#13
Michael A Ramin, Kotagudda Ranganath Sindhu, Ananda Appavoo, Khalid Oumzil, Mark W Grinstaff, Olivier Chassande, Philippe Barthélémy
Hydrogels formed by the self-assembly of low-molecular-weight gelators (LMWGs) are promising scaffolds for drug-delivery applications. A new biocompatible hydrogel, resulting from the self-assembly of nucleotide-lipid salts can be safely injected in vivo. The resulting hydrogel provides sustained-release of protein for more than a week.
February 2, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28142401/functional-outcomes-of-heparin-binding-epidermal-growth-factor-like-growth-factor-for-regeneration-of-chronic-tympanic-membrane-perforations-in-mice
#14
Peter Luke Santa Maria, Peter Gotlieb, Chloe Santa Maria, Sunil Puria, Sungwoo Kim, Yunzhi Peter Yang
We aim to demonstrate that regeneration of chronic tympanic perforations with heparin binding epidermal growth factor like growth factor (HB-EGF) delivered by an injectable hydrogel restored hearing to levels similar to that of non-perforated tympanic membranes. Chronic tympanic membrane perforation is currently managed as an outpatient surgery with tympanoplasty. Due to the costs of this procedure in the developed world and a lack of accessibility and resources in the developing countries, there is a great need for a new treatment that does not require surgery...
January 31, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28130889/bioactive-tricalcium-silicate-alginate-composite-bone-cements-with-enhanced-physicochemical-properties
#15
Chen Xu, Xiaoya Wang, Jie Zhou, Zhiguang Huan, Jiang Chang
Previous studies have shown that tricalcium silicate bone cements possess good bioactivity and appropriate degradation rate. However, they also showed some weaknesses such as poor washout resistance, formability and injectability, which have seriously hindered their clinical applications. The purpose of this study was to develop a new type of bone cements-tricalcium silicate/sodium alginate (C3 S/SA) composites by utilizing the interaction of Ca ions with SA molecules, in which an interpenetrating double-network of calcium hydrate silicate (CSH) and alginate hydrogel was formed to enhance the washout resistance, formability, injectability and compressive strength of C3 S...
January 27, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28126673/niosome-based-hydrogel-of-resveratrol-for-topical-applications-an-effective-therapy-for-pain-related-disorder-s
#16
Poonam Negi, Madhur Aggarwal, Gajanand Sharma, Charul Rathore, Gaurav Sharma, Bhupinder Singh, O P Katare
The present work endeavors for development and evaluation of resveratrol loaded niosomal hydrogel system for its anti-inflammatory action. Niosomes were prepared by thin film hydration and ether injection methods employing Span 80 as a surfactant at three different levels. Best optimized formulation was selected on the basis of entrapment efficiency (% EE), mean particle size, sedimentation volume, and microscopy. The vesicular and spherical nature of the niosomes was confirmed by optical microscopy and transmission electron microscope (TEM)...
January 23, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28121206/a-reconstituted-thermosensitive-hydrogel-system-based-on-paclitaxel-loaded-amphiphilic-copolymer-nanoparticles-and-antitumor-efficacy
#17
Yanqin Liang, Chengxia Dong, Jianhua Zhang, Liandong Deng, Anjie Dong
Combination delivery systems composed of injectable hydrogels and drug-incorporated nanoparticles are urgently in regional cancer chemotherapy to facilitate efficient delivery of chemotherapeutic agents, enhance antitumor efficiency and decrease side effects. Here, we developed a novel thermosensitive amphiphilic triblock copolymer consisting of methoxy poly(ethylene glycol), poly(octadecanedioic anhydride) and D,L-lactic acid oligomer (PEOALA), built a combination system of thermosensitive injectable hydrogel PTX/PEOALA(Gel) based on paclitaxel (PTX)-loaded PEOALA nanoparticles (NPs)...
January 25, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28120848/nanogel-based-nasal-ghrelin-vaccine-prevents-obesity
#18
T Azegami, Y Yuki, S Sawada, M Mejima, K Ishige, K Akiyoshi, H Itoh, H Kiyono
Obesity is associated with multiple comorbidities such as cardiovascular diseases and has a huge economic impact on the health-care system. However, the treatment of obesity remains insufficient in terms of efficacy, tolerability, and safety. Here we created a nasal vaccine against obesity for the first time. To avoid the injectable administration-caused pain and skin-related adverse event, we focused on the intranasal route of antigen delivery. We developed a vaccine antigen (ghrelin-PspA (pneumococcal surface protein A)), which is a recombinant fusion protein incorporating ghrelin, a hormone that stimulates food intake and decreases energy expenditure, and PspA, a candidate of pneumococcal vaccine as a carrier protein...
January 25, 2017: Mucosal Immunology
https://www.readbyqxmd.com/read/28116870/multicomponent-injectable-hydrogels-for-antigen-specific-tolerogenic-immune-modulation
#19
Catia S Verbeke, Susana Gordo, David A Schubert, Sarah A Lewin, Rajiv M Desai, Jessica Dobbins, Kai W Wucherpfennig, David J Mooney
Biomaterial scaffolds that enrich and modulate immune cells in situ can form the basis for potent immunotherapies to elicit immunity or reëstablish tolerance. Here, the authors explore the potential of an injectable, porous hydrogel to induce a regulatory T cell (Treg) response by delivering a peptide antigen to dendritic cells in a noninflammatory context. Two methods are described for delivering the BDC peptide from pore-forming alginate gels in the nonobese diabetic mouse model of type 1 diabetes: encapsulation in poly(lactide-co-glycolide) (PLG) microparticles, or direct conjugation to the alginate polymer...
January 24, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28116831/optimization-of-injectable-thermosensitive-scaffolds-with-enhanced-mechanical-properties-for-cell-therapy
#20
Caroline Ceccaldi, Elias Assaad, Eve Hui, Medeine Buccionyte, Atma Adoungotchodo, Sophie Lerouge
Strong injectable chitosan thermosensitive hydrogels can be created, without chemical modification, by combining sodium hydrogen carbonate with another weak base, namely, beta-glycerophosphate (BGP) or phosphate buffer (PB). Here the influence of gelling agent concentration on the mechanical properties, gelation kinetics, osmolality, swelling, and compatibility for cell encapsulation, is studied in order to find the most optimal formulations and demonstrate their potential for cell therapy and tissue engineering...
January 24, 2017: Macromolecular Bioscience
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