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Injectable hydrogels

Mana Kashi, Fatemeh Baghbani, Fathollah Moztarzadeh, Hamid Mobasheri, Elaheh Kowsari
Electroactive scaffolds containing conductive polymers can promote tissue repair and regeneration. However, these polymers are non-degradable and cannot be removed from body. To overcome this limitation of conductive polymers, we developed a novel injectable electroactive hydrogel containing pyrrole oligomers which possessed the unique properties of being both electrically conductive and biodegradable. First, pyrrole oligomers were synthesized via chemical polymerization and were found to be amorphous with a non-globular morphology...
October 10, 2017: International Journal of Biological Macromolecules
Prathamesh M Kharkar, Rebecca A Scott, Laura P Olney, Paige J LeValley, Emanual Maverakis, Kristi L Kiick, April M Kloxin
Injectable delivery systems that respond to biologically relevant stimuli present an attractive strategy for tailorable drug release. Here, the design and synthesis of unique polymers are reported for the creation of hydrogels that are formed in situ and degrade in response to clinically relevant endogenous and exogenous stimuli, specifically reducing microenvironments and externally applied light. Hydrogels are formed with polyethylene glycol and heparin-based polymers using a Michael-type addition reaction...
October 12, 2017: Advanced Healthcare Materials
V H Giang Phan, Thavasyappan Thambi, Bong Sup Kim, Dai Phu Huynh, Doo Sung Lee
Stimuli-responsive hydrogels, known as smart hydrogels, are three-dimensional amphiphilic or hydrophilic polymer networks that are able to change their volume or phase, and other properties, including viscosity, structure, and dimension, in response to changes in pH, temperature, and magnetic or electric field. Highly swellable, dual-responsive bovine serum albumin (BSA)-based injectable hydrogels are prepared here by the chemical conjugation of pH- and temperature-responsive oligo(sulfamethazine acrylate-co-N-isopropylacrylamide) (oligo(SMA-co-NIPAM)) copolymers on the surface of BSA through carbodiimide-mediated chemistry...
October 11, 2017: Biomaterials Science
Ruixue Bai, Xueqing Deng, Qiong Wu, Xiaomian Cao, Tiantian Ye, Shujun Wang
Main challenges of the clinical use of 7-ethyl-10-hydroxycamptothecin (SN-38) are its facile transition between the active lactone form (SN-38A) and the inactive carboxylate form (SN-38I) under physiological conditions and its low solubility. The purpose of this study was to develop a thermo-sensitive hydrogel system with acidic SN-38 liposomes (SN-38-Lip-Gel) for local chemotherapy to solve these problems and to evaluate its antitumor activity and tissue distribution in tumor-bearing mice. A study of structural conversion between SN-38I and SN-38A under various pH conditions indicated that acidic solution could inhibit the conversion...
October 11, 2017: Pharmaceutical Development and Technology
Yongsan Li, Yaling Zhang, Yen Wei, Lei Tao
The protocol presents a facile, efficient, and versatile method to prepare chitosan-based hydrogels using dynamic imine chemistry. The hydrogel is prepared by mixing solutions of glycol chitosan with a synthesized benzaldehyde terminated polymer gelator, and hydrogels are efficiently obtained in several minutes at room temperature. By varying ratios between glycol chitosan, polymer gelator, and water contents, versatile hydrogels with different gelation times and stiffness are obtained. When damaged, the hydrogel can recover its appearances and modulus, due to the reversibility of the dynamic imine bonds as crosslinkages...
September 29, 2017: Journal of Visualized Experiments: JoVE
Lingling Zhao, Lijing Niu, Hongze Liang, Hui Tan, Chaozong Liu, Feiyan Zhu
pH and glucose dual-responsive injectable hydrogels were prepared through the crosslinking of Schiff's base and phenylboronate ester using phenylboronic modified chitosan, polyvinyl alcohol and benzaldehyde-capped poly(ethylene glycol). Protein drugs and live cells could be incorporated into the hydrogels during the in situ crosslinking, displaying sustained and pH/glucose triggered drug release from the hydrogels, and cell viability and proliferation in the three-dimensional hydrogel matrix as well. Hence, the hydrogels with insulin and fibroblasts were considered as bioactive dressings for diabetic wound healing...
October 10, 2017: ACS Applied Materials & Interfaces
Josh Erndt-Marino, Erik Trinkle, Mariah S Hahn
Objective The main goal of this study was to provide a proof-of-concept demonstrating that hyperosmolar K(+) solutions can limit production of catabolic and inflammatory mediators in human osteoarthritic chondrocytes (OACs). Methods A 3-dimensional in vitro model with poly(ethylene glycol) diacrylate (PEGDA) hydrogels was used. Catabolic and pro-inflammatory protein production from encapsulated OACs was assessed following culture for 1 or 7 days in the presence or absence of 80 mM K(+) gluconate, 80 mM sodium (Na(+)) gluconate, or 160 mM sucrose, each added to culture media (final osmolarity ~490 mOsm)...
October 1, 2017: Cartilage
Andre Chow, Daniel J Stuckey, Emaddin Kidher, Mark Rocco, Richard J Jabbour, Catherine A Mansfield, Ara Darzi, Sian E Harding, Molly M Stevens, Thanos Athanasiou
Tissue engineering offers an exciting possibility for cardiac repair post myocardial infarction. We assessed the effects of combined polyethylene glycol hydrogel (PEG), human induced pluripotent stem cell-derived cardiomyocyte (iPSC-CM), and erythropoietin (EPO) therapy in a rat model of myocardial infarction. PEG with/out iPSC-CMs and EPO; iPSC-CMs in saline; or saline alone was injected into infarcted hearts shortly after infarction. Injection of almost any combination of the therapeutics limited acute elevations in chamber volumes...
October 4, 2017: Stem Cell Reports
Heemin Kang, Minkyu Kim, Qian Feng, Sien Lin, Kongchang Wei, Rui Li, Chan Ju Choi, Tae-Hyun Kim, Gang Li, Jae-Min Oh, Liming Bian
Cellular behaviors, such as differentiation, are regulated by complex ligation processes involving cell surface receptors, which can be activated by various divalent metal cations. The design of nanoparticle for co-delivery of ligand and ligation activator can offer a novel strategy to synergistically stimulate ligation processes in vivo. Here, we present a novel layered double hydroxide (LDH)-based nanohybrid (MgFe-Ado-LDH), composed of layered MgFe hydroxide nanocarriers sandwiching the adenosine cargo molecule, maintained through an electrostatic balance, to co-deliver the adenosine (Ado) ligand from the interlayer spacing and the Mg(2+) ion (ligation activator) through the dissolution of the MgFe nanocarrier itself...
September 29, 2017: Biomaterials
Kaitlin C Murphy, Jacklyn Whitehead, Dejie Zhou, Steve S Ho, J Kent Leach
Mesenchymal stem cells (MSCs) secrete endogenous factors such as vascular endothelial growth factor (VEGF) and prostaglandin E2 (PGE2) that promote angiogenesis, modulate the inflammatory microenvironment, and stimulate wound repair, and MSC spheroids secrete more trophic factors than dissociated, individual MSCs. Compared to injection of cells alone, transplantation of MSCs in a biomaterial can enhance their wound healing potential by localizing cells at the defect site and upregulating trophic factor secretion...
October 5, 2017: Acta Biomaterialia
Tiantian Luo, Tingwang Guo, Qian Yang, Shilei Hao, Ju Wang, Zhongjun Cheng, Qing Qu, Ye He, Yuhua Gong, Feiyan Gao, Wenfeng Li, Haijian Xia, Bochu Wang
The role of surgery for most patients with spontaneous intracerebral haemorrhage (ICH) remains controversial due to the continuous occurrence of postoperative iron overload induced by low clot clearance rate. In this study, human hair keratose hydrogel (KG) loading with minocycline hydrochloride (MH) were prepared to reduce iron overload for the improvement of the postoperative functional recovery after ICH aspiration surgery. Hemoglobin-induced iron accumulation in rat primary neuronal culture was delayed by the adsorptive capacity of blank KG, while MH-loaded KG displayed a stronger and more thorough cytoprotective effect than blank KG due to the combined effect of absorptive action to iron and sustained release of the iron chelator...
October 5, 2017: International Journal of Pharmaceutics
Avani D Rao, Stephanie Coquia, Robert De Jong, Christine Gourin, Brandi Page, Diane Latronico, Samson Dah, Lin Su, Stephen Clarke, Jeffrey Schultz, Lauren M Rosati, Carole Fakhry, John Wong, Theodore L DeWeese, Harry Quon, Kai Ding, Ana Kiess
Xerostomia is the most common late toxicity after head and neck radiation. We demonstrate injection of a hydrogel spacer anteriorly displacing the submandibular gland. This procedure enables reduced dose to the displaced submandibular gland in cadaveric models of oropharynx cancer treated with IMRT, with potential implications in reducing xerostomia risk.
October 3, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Pravin Mundada, Romain Kohler, Sana Boudabbous, Laurence Toutous Trellu, Alexandra Platon, Minerva Becker
Injectable fillers are widely used for facial rejuvenation, correction of disabling volumetric fat loss in HIV-associated facial lipoatrophy, Romberg disease, and post-traumatic facial disfiguring. The purpose of this article is to acquaint the reader with the anatomy of facial fat compartments, as well as with the properties and key imaging features of commonly used facial fillers, filler-related complications, interpretation pitfalls, and dermatologic conditions mimicking filler-related complications. The distribution of facial fillers is characteristic and depends on the anatomy of the superficial fat compartments...
October 4, 2017: Insights Into Imaging
Na-Kyung Ryoo, Jihwang Lee, Hyunjoo Lee, Hye Kyoung Hong, Hyejin Kim, Jong Bum Lee, Se Joon Woo, Kyu Hyung Park, Hyuncheol Kim
Age-related macular degeneration (AMD) is the leading cause of blindness in developed countries and is characterized by the development of choroidal neovascularization (CNV). Therapies for AMD have focused on suppressing angiogenic factors, such as vascular endothelial growth factor (VEGF), mainly via conventional anti-VEGF antibody agents. However, additional efforts have been made to develop effective small-interfering RNA (siRNA)-based intracellular therapeutic agents. In this study, we have manufactured a novel siRNA-based anti-VEGF nanoball (siVEGF NB)...
October 4, 2017: Nanoscale
Jing Xie, Anqi Li, Jianshu Li
Since diabetes mellitus has become one of the most serious threats to human health, researchers have been designing new drugs and developing new technologies to control the blood glucose level (BGL) while improving patient compliance. In addition to the traditional subcutaneous injection method, alternative routes of insulin delivery have been investigated and tested, including oral, pulmonary, transdermal, and nasal. The final goal of all these technologies is to develop a system that releases insulin in a controlled manner depending on the BGL...
October 4, 2017: Macromolecular Rapid Communications
Beom Soo Jo, Yunki Lee, Jin Sook Suh, Yoon Shin Park, Hyun Jung Lee, Jue-Yeon Lee, Jaejin Cho, Gene Lee, Chong Pyoung Chung, Ki Dong Park, Yoon Jeong Park
Bioactive agents, including proteins and peptides, can be loaded into hydrogels to improve bone regenerative capacity with their controlled release. However, the current loading method has focused on physical mixing, which has limited release control. Therefore, alternative conjugation of bioactive agents with hydrogels is highly recommended. Direct chemical conjugation of synthetic peptides containing a functional moiety with a hydrogel would be ideal. Here, we synthesized a bioactive calcium accumulating peptide (CAP) containing a collagen binding motif (CBM), which can induce osteogenic differentiation...
October 4, 2017: Journal of Biomedical Materials Research. Part A
Cecilia Pascual-Garrido, Francisco Rodriguez-Fontan, Elizabeth A Aisenbrey, Karin A Payne, Jorge Chahla, Laurie R Goodrich, Stephanie J Bryant
Focal chondral lesions and early osteoarthritis (OA) are responsible for progressive joint pain and disability in millions of people worldwide, yet there is currently no surgical joint preservation treatment available to fully restore the long term functionality of cartilage. Limitations of current treatments for cartilage defects have prompted the field of cartilage tissue engineering, which seeks to integrate engineering and biological principles to promote the growth of new cartilage to replace damaged tissue...
October 3, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
Nima A Jalili, Manish K Jaiswal, Charles W Peak, Lauren M Cross, Akhilesh K Gaharwar
"Smart" hydrogels are an emerging class of biomaterials that respond to external stimuli and have been investigated for a range of biomedical applications, including therapeutic delivery and regenerative engineering. Stimuli-responsive nanogels constructed of thermoresponsive polymers such as poly(N-isopropylacrylamide-co-acrylamide) (poly(NIPAM-co-AM)) and magnetic nanoparticles (MNPs) have been developed as "smart carriers" for on-demand delivery of therapeutic biomolecules via magneto-thermal activation...
October 4, 2017: Nanoscale
Fuli Zhao, Di Wu, Dan Yao, Ruiwei Guo, Weiwei Wang, Anjie Dong, Deling Kong, Jianhua Zhang
Long-term and daily subcutaneous injections of insulin for the treatment of insulin-dependent diabetic patients often lead to poor patient compliance and undesired complications. Phenylboronic acid (PBA)-based polymeric hydrogels have been widely considered as one of the most promising insulin delivery system to replace the frequent insulin injections. However, their applications are limited by clinically irrelevant glucose-responsive range, slow response rate, low tissue-adhesiveness and poor biodegradability, undesirable leakage at normoglycemic state...
September 30, 2017: Acta Biomaterialia
W C Mak, B Magne, K Y Cheung, D Atanasova, M Griffith
Human mesenchymal stromal cells (hMSCs) are adult-source cells that have been extensively evaluated for cell-based therapies. hMSCs delivered by intravascular injection have been reported to accumulate at the sites of injury to promote tissue repair and can also be employed as vectors for the delivery of therapeutic genes. However, the full potential of hMSCs remains limited as the cells are lost after injection due to anoikis and the adverse pathologic environment. Encapsulation of cells has been proposed as a means of increasing cell viability...
October 3, 2017: Biomaterials Science
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