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Hydrogels

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https://www.readbyqxmd.com/read/29244943/electrical-programming-of-soft-matter-using-temporally-varying-electrical-inputs-to-spatially-control-self-assembly
#1
Kun Yan, Yi Liu, Jitao Zhang, Santiago O Correa, Wu Shang, Cheng-Chieh Tsai, William E Bentley, Jana Shen, Giuliano Scarcelli, Christopher B Raub, Xiao-Wen Shi, Gregory F Payne
The growing importance of hydrogels in translational medicine has stimulated the development of top-down fabrication methods, yet often these methods lack the capabilities to generate the complex matrix architectures observed in biology. Here we show that temporally varying electrical signals can cue a self-assembling polysaccharide to controllably form a hydrogel with complex internal patterns. Evidence from theory and experiment indicate that internal structure emerges through a subtle interplay between: the electrical current which triggers self-assembly; and the electrical potential (or electric field) which recruits and appears to orient the polysaccharide chains at the growing gel front...
December 15, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/29244868/cyclodextrin-containing-hydrogels-as-an-intraocular-lens-for-sustained-drug-release
#2
Xiao Li, Yang Zhao, Kaijie Wang, Lei Wang, Xiaohui Yang, Siquan Zhu
To improve the efficacy of anti-inflammatory factors in patients who undergo cataract surgery, poly(2-hydroxyethyl methacrylate-co-methyl methacrylate) (p(HEMA-co-MMA)) hydrogels containing β-cyclodextrin (β-CD) (pHEMA/MMA/β-CD) were designed and prepared as intraocular lens (IOLs) biomaterials that could be loaded with and achieve the sustained release of dexamethasone. A series of pHEMA/MMA/β-CD copolymers containing different ratios of β-CD (range, 2.77 to 10.24 wt.%) were obtained using thermal polymerization...
2017: PloS One
https://www.readbyqxmd.com/read/29243352/a-review-on-gradient-hydrogel-fiber-scaffolds-for-osteochondral-regeneration
#3
REVIEW
Sajedeh Khorshidi, Akbar Karkhaneh
Osteochondral tissue regeneration is a complicated field due to the distinct properties and healing potential of osseous and chondral phases. In a natural osteochondral region, the composition, mechanics and structure vary smoothly from bony to cartilaginous phase. Therefore, a homogeneous scaffold cannot satisfy the complexity of the osteochondral matrix. In essence, a natural extracellular matrix (ECM) is composed of fibrous proteins elongated into a gelatinous background. A hydrogel/fiber scaffold possessing gradient in both phases would be of the utmost interest to imitate tissue arrangement of a native osteochondral interface...
December 15, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29243106/quantitative-validation-of-immunofluorescence-and-lectin-staining-using-reduced-clarity-acrylamide-formulations
#4
D M Krolewski, V Kumar, B Martin, R Tomer, K Deisseroth, R M Myers, A F Schatzberg, F S Lee, J D Barchas, W E Bunney, H Akil, S J Watson
The CLARITY technique enables three-dimensional visualization of fluorescent-labeled biomolecules in clarified intact brain samples, affording a unique view of molecular neuroanatomy and neurocircuitry. It is therefore, essential to find the ideal combination for clearing tissue and detecting the fluorescent-labeled signal. This method requires the formation of a formaldehyde-acrylamide fixative-generated hydrogel mesh through which cellular lipid is removed with sodium dodecyl sulfate. Several laboratories have used differential acrylamide and detergent concentrations to achieve better tissue clearing and antibody penetration, but the potential effects upon fluorescent signal retention is largely unknown...
December 14, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/29242870/high-throughput-double-emulsion-based-microfluidic-production-of-hydrogel-microspheres-with-tunable-chemical-functionalities-toward-biomolecular-conjugation
#5
Eric Y Liu, Sukwon Jung, David A Weitz, Hyunmin Yi, Chang-Hyung Choi
Chemically functional hydrogel microspheres hold significant potential in a range of applications including biosensing, drug delivery, and tissue engineering due to their high degree of flexibility in imparting a range of functions. In this work, we present a simple, efficient, and high-throughput capillary microfluidic approach for controlled fabrication of monodisperse and chemically functional hydrogel microspheres via formation of double emulsion drops with an ultra-thin oil shell as a sacrificial template...
December 15, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/29242160/the-impact-of-functional-groups-of-poly-ethylene-glycol-macromers-on-the-physical-properties-of-photo-polymerized-hydrogels-and-the-local-inflammatory-response-in-the-host
#6
James R Day, Anu David, Jiwon Kim, Evan A Farkash, Marilia Cascalho, Nikola Milašinović, Ariella Shikanov
Poly(ethylene glycol) (PEG) can be functionalized and modified with various moieties allowing for a multitude of cross-linking chemistries. Here, we investigate how vinyl sulfone, acrylate, and maleimide functional end groups affect hydrogel formation, physical properties, viability of encapsulated cells, post-polymerization modification, and inflammatory response of the host. We have shown that PEG-VS hydrogels, in the presence of a co-monomer, N-vinyl-2-pyrrolidone (NVP), form more efficiently than PEG-Ac and PEG-Mal hydrogels, resulting in superior physical properties after 6 minutes of ultraviolet light exposure...
December 11, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29241942/an-imaging-based-analysis-of-lipid-deposits-on-contact-lens-surfaces
#7
Shyam Panthi, Jason J Nichols
PURPOSE: To evaluate whether LipidTOX could stain lipid deposits on contact lens (CL) surfaces and compare lipid deposition patterns on various CL surfaces using an imaging method. METHODS: Ten CLs each of six silicone hydrogel materials and one hydrogel material were incubated in cholesteryl oleate solution (5.60mg/ml) for 12hours. The CLs were then separately stained with Oil Red O and LipidTOX and imaged under a fluorescence microscope. Twenty worn senofilcon A CLs from both eyes of ten participants were also stained similarly...
December 11, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/29241706/placement-of-an-absorbable-rectal-hydrogel-spacer-in-patients-undergoing-low-dose-rate-brachytherapy-with-palladium-103
#8
Amandeep S Taggar, Tomer Charas, Gil'ad N Cohen, Keeratikarn Boonyawan, Marisa Kollmeier, Sean McBride, Nitin Mathur, Antonio L Damato, Michael J Zelefsky
PURPOSE: Rates of rectal toxicity after low-dose-rate (LDR) brachytherapy for prostate cancer are dependent on rectal dose, which is associated with rectal distance from prostate and implanted seeds. Placement of a hydrogel spacer between the prostate and rectum has proven to reduce the volume of the rectum exposed to higher radiation dose levels in the setting of external beam radiotherapy. We present our findings with placing a rectal hydrogel spacer in patients following LDR brachytherapy, and we further assess the impact of this placement on dosimetry and acute rectal toxicity...
December 11, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29241441/antibody-separation-using-lectin-modified-poly-hema-edma-hydrogel-membranes
#9
Esra Feyzioğlu Demir, Cansu Ilke Kuru, Murat Uygun, Deniz Aktaş Uygun, Sinan Akgöl
Herein we describe the synthesis of Concanavalin A-poly(2-hydroxyethyl methacrylate-ethylene dimethacrylate) hydrogel membranes (via photopolymerization technique) for antibody separation from aqueous solutions. Different characterization techniques including Scanning Electron Microscopy, Fourier Transform Infrared Spectroscopy, Elemental Analysis and swelling tests revealed the highly rough morphology and spherical shape of the as-synthetized membranes. Attached amount of IMEO (salinization agent) onto polymeric structure and Con A binding capacity were found to be 10...
December 15, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/29240845/ras-gap-related-and-c-terminal-domain-dependent-localization-and-tumorigenic-activities-of-iqgap1-in-melanoma-cells
#10
Michael Reimer, Elisabeth Denby, Silviya P Zustiak, Joseph M Schober
IQGAP1 interacts with a number of binding partners through a calponin homology domain (CHD), a WW motif, IQ repeats, a Ras GAP-related domain (GRD), and a conserved C-terminal (CT) domain. Among various biological and cellular functions, IQGAP1 is known to play a role in actin cytoskeleton dynamics during membrane ruffling and lamellipodium protrusion. In addition, phosphorylation near the CT domain is thought to control IQGAP1 activity through regulation of intramolecular interaction. In a previous study, we discovered that IQGAP1 preferentially localizes to retracting areas in B16F10 mouse melanoma cells, not areas of membrane ruffling and lamellipodium protrusion...
2017: PloS One
https://www.readbyqxmd.com/read/29240797/a-mucoadhesive-thermoreversible-in-situ-nasal-gel-of-geniposide-for-neurodegenerative-diseases
#11
Yingting Wang, Shulong Jiang, Hongli Wang, Haiyan Bie
Neurodegenerative diseases are becoming prevalent as the population ages. Geniposide could inhibit oxidative stress, reduce apoptosis, protect neuron, and has been used for therapy of the neurodegenerative diseases. The bioavailability of geniposide by nasal route is greater than that by oral administration. However, mucociliary clearance is a rate-limiting factor for nasal route administration. The objective of this study was to develop and evaluate a mucoadhesive, thermoreversible in situ nasal gel of geniposide...
2017: PloS One
https://www.readbyqxmd.com/read/29240313/deconvolution-of-images-from-3d-printed-cells-in-layers-on-a-chip
#12
Sean Yu, Pranav Joshi, Yi Ju Park, Kyeong-Nam Yu, Moo-Yeal Lee
Layer-by-layer cell printing is useful in mimicking layered tissue structures inside the human body and has great potential for being a promising tool in the field of tissue engineering, regenerative medicine, and drug discovery. However, imaging human cells cultured in multiple hydrogel layers in 3D-printed tissue constructs is challenging as the cells are not in a single focal plane. Although confocal microscopy could be a potential solution for this issue, it compromises the throughput which is a key factor in rapidly screening drug efficacy and toxicity in pharmaceutical industries...
December 14, 2017: Biotechnology Progress
https://www.readbyqxmd.com/read/29239747/functional-testing-on-engineered-cartilage-to-identify-the-role-played-by-shearing
#13
Ling Wang, Hao Shen, Jichang Nie, Dichen Li, Hongbin Fan, Zhongmin Jin, Chaozong Liu
Compressive loading is crucial for tissue regeneration in cartilage; however, the role played by shearing induced from translational or rotational motion of the knee joint has yet to be identified. This study aims at investigating the effects of in vivo like dynamic load-compression integrated with shearing on tissue regeneration, particularly to identify the role played by shearing induced from rotational motion. Tissue samples fabricated from a calcium alginate hydrogel embedded with chondrocytes were subjected to a dynamic tissue culture...
November 24, 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/29239354/an-electric-eel-inspired-soft-power-source-from-stacked-hydrogels
#14
Thomas B H Schroeder, Anirvan Guha, Aaron Lamoureux, Gloria VanRenterghem, David Sept, Max Shtein, Jerry Yang, Michael Mayer
Progress towards the integration of technology into living organisms requires electrical power sources that are biocompatible, mechanically flexible, and able to harness the chemical energy available inside biological systems. Conventional batteries were not designed with these criteria in mind. The electric organ of the knifefish Electrophorus electricus (commonly known as the electric eel) is, however, an example of an electrical power source that operates within biological constraints while featuring power characteristics that include peak potential differences of 600 volts and currents of 1 ampere...
December 13, 2017: Nature
https://www.readbyqxmd.com/read/29239103/out-of-plane-3d-printed-microfibers-improve-the-shear-properties-of-hydrogel-composites
#15
Mylène de Ruijter, Andrei Hrynevich, Jodie N Haigh, Gernot Hochleitner, Miguel Castilho, Jürgen Groll, Jos Malda, Paul D Dalton
One challenge in biofabrication is to fabricate a matrix that is soft enough to elicit optimal cell behavior while possessing the strength required to withstand the mechanical load that the matrix is subjected to once implanted in the body. Here, melt electrowriting (MEW) is used to direct-write poly(ε-caprolactone) fibers "out-of-plane" by design. These out-of-plane fibers are specifically intended to stabilize an existing structure and subsequently improve the shear modulus of hydrogel-fiber composites. The stabilizing fibers (diameter = 13...
December 14, 2017: Small
https://www.readbyqxmd.com/read/29238786/unravelling-cationic-cellulose-nanofibril-hydrogel-structure-nmr-spectroscopy-and-small-angle-neutron-scattering-analyses
#16
James C Courtenay, Susana M Ramalhete, William J Skuze, Rhea Soni, Yaroslav Z Khimyak, Karen J Edler, Janet L Scott
Stiff, elastic, viscous shear thinning aqueous gels are formed upon dispersion of low weight percent concentrations of cationically modified cellulose nanofibrils (CCNF) in water. CCNF hydrogels produced from cellulose modified with glycidyltrimethylammonium chloride, with degree of substitution (DS) in the range 10.6(3)-23.0(9)%, were characterised using NMR spectroscopy, rheology and small angle neutron scattering (SANS) to probe the fundamental form and dimensions of the CCNF and to reveal interfibrillar interactions leading to gelation...
December 13, 2017: Soft Matter
https://www.readbyqxmd.com/read/29238048/cardiac-regeneration-a-hydrogel-mirna-complex-stimulates-heart-recovery
#17
Irene Fernández-Ruiz
No abstract text is available yet for this article.
December 14, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/29237757/urine-lipoarabinomannan-glycan-in-hiv-negative-patients-with-pulmonary-tuberculosis-correlates-with-disease-severity
#18
Luisa Paris, Ruben Magni, Fatima Zaidi, Robyn Araujo, Neal Saini, Michael Harpole, Jorge Coronel, Daniela E Kirwan, Hannah Steinberg, Robert H Gilman, Emanuel F Petricoin, Roberto Nisini, Alessandra Luchini, Lance Liotta
An accurate urine test for pulmonary tuberculosis (TB), affecting 9.6 million patients worldwide, is critically needed for surveillance and treatment management. Past attempts failed to reliably detect the mycobacterial glycan antigen lipoarabinomannan (LAM), a marker of active TB, in HIV-negative, pulmonary TB-infected patients' urine (85% of 9.6 million patients). We apply a copper complex dye within a hydrogel nanocage that captures LAM with very high affinity, displacing interfering urine proteins. The technology was applied to study pretreatment urine from 48 Peruvian patients, all negative for HIV, with microbiologically confirmed active pulmonary TB...
December 13, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/29237366/antigen-antibody-interaction-based-self-healing-capability-of-hybrid-hydrogels-composed-of-genetically-engineered-filamentous-viruses-and-gold-nanoparticles
#19
Toshiki Sawada, Takeshi Serizawa
M13 phages, a type of filamentous virus, have recently been utilized as components for developing novel functional soft materials in various fields. Herein, we demonstrated the self-healing capability of hybrid hydrogels composed of antigen peptide-displaying M13 phages and antibody-immobilized gold nanoparticles (GNPs). The addition of small amounts of buffer solutions to the rupture points of the hybrid hydrogels followed by incubation resulted in self-healing, possibly due to specific interactions between the components...
December 13, 2017: Protein and Peptide Letters
https://www.readbyqxmd.com/read/29237351/fabrication-and-characterization-of-a-novel-collagen-catechol-hydrogel
#20
Lian Duan, Qijuan Yuan, Hongzhao Xiang, Xiao Yang, Lindong Liu, Jiao Li
3,4-Dihydroxybenzaldehyde, a derivative of catechol and an agent with an extensive pharmacological and biological activities, was used to modify collagen and prepared hydrogels. The aldehyde group of 3,4-dihydroxybenzaldehyde interacted with the ɛ-amino group of collagen, and then the catechol group of 3,4-dihydroxybenzaldehyde was oxidized and self-polymerized. The chemical network formed due to the cross-linking bridges of polymerized catechol groups among collagen molecules, resulting in the transformation from solution to hydrogel...
January 1, 2017: Journal of Biomaterials Applications
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