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https://www.readbyqxmd.com/read/29911990/3d-bioprinting-of-scaffolds-with-living-schwann-cells-for-potential-nerve-tissue-engineering-applications
#1
Liqun Ning, Haoying Sun, Tiphanie Lelong, Romain Guilloteau, Ning Zhu, David J Schreyer, Daniel Xiongbiao Chen
Three-dimensional (3D) bioprinting of biomaterials shows great potential for producing cell-encapsulated scaffolds to repair nerves after injury or disease. For this, preparation of biomaterials and bioprinting itself are critical to create scaffolds with both biological and mechanical properties appropriate for nerve regeneration, yet remain unachievable. This paper presents our study on bioprinting Schwann cell-encapsulated scaffolds using composite hydrogels of alginate, fibrin, hyaluronic acid, and/or RGD peptide, for nerve tissue engineering applications...
June 18, 2018: Biofabrication
https://www.readbyqxmd.com/read/29911317/simultaneous-micropatterning-of-fibrous-meshes-and-bioinks-for-the-fabrication-of-living-tissue-constructs
#2
Mylène de Ruijter, Alexandre Ribeiro, Inge Dokter, Miguel Castilho, Jos Malda
Fabrication of biomimetic tissues holds much promise for the regeneration of cells or organs that are lost or damaged due to injury or disease. To enable the generation of complex, multicellular tissues on demand, the ability to design and incorporate different materials and cell types needs to be improved. Two techniques are combined: extrusion-based bioprinting, which enables printing of cell-encapsulated hydrogels; and melt electrowriting (MEW), which enables fabrication of aligned (sub)-micrometer fibers into a single-step biofabrication process...
June 17, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29910942/protein-scaffolded-dna-tetrads-enable-efficient-delivery-and-ultrasensitive-imaging-of-mirna-through-crosslinking-hybridization-chain-reaction
#3
Du-Juan Huang, Zhi-Mei Huang, Hu-Yan Xiao, Zhen-Kun Wu, Li-Juan Tang, Jian-Hui Jiang
Efficient intracellular delivery of nucleic acids to achieve sensitive detection and gene regulation is essential for chemistry and biology. Here we developed a novel protein scaffolded DNA tetrad, a four-arm DNA nanostructure constructed using streptavidin (SA) protein and four biotinylated hairpin DNA probes for efficient nucleic acid delivery and ultrasensitive miRNA imaging through crosslinking hybridization chain reaction (cHCR). DNA tetrads were easy to prepare and allowed precise control of the structure of the probes...
June 7, 2018: Chemical Science
https://www.readbyqxmd.com/read/29910172/varicocele-embolization-anatomical-variations-of-the-left-internal-spermatic-vein-and-endovascular-treatment-with-different-types-of-coils
#4
E Perdikakis, I Fezoulidis, V Tzortzis, C Rountas
PURPOSE: To present anatomical variations of left internal spermatic vein and a comparison between treatments with hydrogel-coated and non-coated platinum coils in patients with varicocele. MATERIALS AND METHODS: A total of 153 men (mean age, 27.5±6.7 [SD] years; range: 18-45 years) with left sided varicocele underwent coil embolization. Anatomic variants of gonadal vein were categorized into five subtypes (I-V). Additional venous collaterals were also recorded...
June 14, 2018: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/29910163/prostatic-artery-embolization-with-250-%C3%AE-m-spherical-polyzene-coated-hydrogel-microspheres-for-lower-urinary-tract-symptoms-with-follow-up-mr-imaging
#5
Tobias Franiel, René Aschenbach, Sarah Trupp, Thomas Lehmann, Friedrich-Carl von Rundstedt, Marc-Oliver Grimm, Ulf Teichgräber
PURPOSE: To evaluate clinical outcomes and possible MR imaging predictors of clinical success after prostatic artery embolization (PAE) with 250-μm hydrogel particles. MATERIALS AND METHODS: During a span of 1.5 years, 30 patients with moderate to severe lower urinary tract symptoms were included in a prospective, nonrandomized study. Embolization of at least one prostatic artery was considered as technical success. International Prostate Symptom Score (IPSS), quality of life (QOL), peak urinary flow rate (Qmax ), residual urine volume, prostate volume, prostate-specific antigen level, and International Index of Erectile Function (IIEF) were recorded at baseline and at 1, 3, and 6 months after PAE...
June 14, 2018: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29909038/engineered-stem-cell-mimics-to-enhance-stroke-recovery
#6
Paul M George, Byeongtaek Oh, Ruby Dewi, Thuy Hua, Lei Cai, Alexa Levinson, Xibin Liang, Brad A Krajina, Tonya M Bliss, Sarah C Heilshorn, Gary K Steinberg
Currently, no medical therapies exist to augment stroke recovery. Stem cells are an intriguing treatment option being evaluated, but cell-based therapies have several challenges including developing a stable cell product with long term reproducibility. Since much of the improvement observed from cellular therapeutics is believed to result from trophic factors the stem cells release over time, biomaterials are well-positioned to deliver these important molecules in a similar fashion. Here we show that essential trophic factors secreted from stem cells can be effectively released from a multi-component hydrogel system into the post-stroke environment...
June 13, 2018: Biomaterials
https://www.readbyqxmd.com/read/29909035/bacterial-cellulose-lignin-composite-hydrogel-as-a-promising-agent-in-chronic-wound-healing
#7
Danica Zmejkoski, Dragica Spasojević, Irina Orlovska, Natalia Kozyrovska, Marina Soković, Jasmina Glamočlija, Svetlana Dmitrović, Branko Matović, Nikola Tasić, Vuk Maksimović, Mikhail Sosnin, Ksenija Radotić
Lignins and lignin-derived compounds are known to have antibacterial properties. The wound healing agents in the form of dressings produce faster skin repair and decrease pain in patients. In order to create an efficient antimicrobial agent in the form of dressing in the treatment of chronic wounds, a composite hydrogel of bacterial cellulose (BC) and dehydrogenative polymer of coniferyl alcohol (DHP), BC-DHP, was designed. Novel composite showed inhibitory or bactericidal effects against selected pathogenic bacteria, including clinically isolated ones...
June 14, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29909030/preparation-and-evaluation-of-%C3%AE-glucan-hydrogel-prepared-by-the-radiation-technique-for-drug-carrier-applications
#8
Jong-Seok Park, Youn-Mook Lim, Jae Baik, Jin-Oh Jeong, Sung-Jun An, Sung-In Jeong, Hui-Jeong Gwon, Myung-Seob Khil
β-Glucan can provide excellent environment to apply to drug carrier due to its immunological and anti-inflammatory effect. Minocycline hydrochloride (MH) has excellent oral bioavailability pharmacological properties. Specifically, MH is effectively absorbed into the gingiva for periodontal disease treatment. In this study, we attempt to develop MH loaded β-glucan hydrogel for periodontal disease treatment through radiation-crosslinking technique. In addition, MH loaded β-glucan hydrogels were tested for their cytotoxicity and antibacterial activity...
June 14, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29908487/dynamic-properties-of-hydrogels-and-fiber-reinforced-hydrogels
#9
Nicholas Martin, George Youssef
Hydrophilic polymers, or hydrogels, are used for a wide variety of biomedical applications, due to their inherent ability to withhold a high-water content. In recent years, a large effort has been focused on tailoring the mechanical properties of these hydrogels to become more appropriate materials for use as anatomical and physiological structural supports. A few of these such methods include using diverse types of polymers, both natural and synthetic, varying the type of molecular cross-linking, as well as combining these efforts to form interpenetrating polymer network hydrogels...
June 7, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29908277/dual-responsive-ipn-hydrogel-based-on-sugarcane-bagasse-cellulose-as-drug-carrier
#10
Yuanfeng Pan, Jingchun Wang, PingxiongCai, Huining Xiao
In this work, the stepwise synthesis of interpenetrating polymer network (IPN) strategy was developed in an attempt to fabricate novel hydrogels consisting of sugarcane bagasse cellulose (SBC), carboxymethylcellulose (CMC) and poly (N-isopropylacrylamide) (PNIPAm) as a dual-responsive drug carrier. The pretreated and dissolved SBC was pre-crosslinked using epichlorohydrin in the presence of CMC, followed by in-situ free-radical polymerization of NIPAm in the presence of N,N'-Methylene-bis(acrylamide) as a crosslinking agent...
June 13, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29906673/features-of-the-volume-change-and-a-new-constitutive-equation-of-hydrogels-under-uniaxial-compression
#11
Y R Zhang, K J Xu, Y L Bai, L Q Tang, Z Y Jiang, Y P Liu, Z J Liu, L C Zhou, X F Zhou
For high-water content hydrogels in compression, the water inside of hydrogels contributes to the response of hydrogels to external loads directly, but part of the water is expelled from hydrogels in the meantime to change the volume of the hydrogel and reduce the contribution. In order to consider the contribution of the water in the constitution equation, PVA (polyvinyl alcohol) hydrogels with high-water content were used as examples, and compressive experiments were carried out to measure both the stress-strain relation and the change of the volume in the meantime...
June 5, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29905394/an-intrinsically-self-healing-nico-zn-rechargeable-battery-by-self-healable-ferric-ion-crosslinking-sodium-polyacrylate-hydrogel-electrolyte
#12
Yan Huang, Jie Liu, Jiaqi Wang, Mengmeng Hu, Funian Mo, Guojin Liang, Chunyi Zhi
Self-healing solid-state aqueous rechargeable NiCo//Zn batteries are an essential element of flexible/wearable electronics due to their inherent safety, high energy density and mechanical robustness etc. However, the self-healability of solid-state batteries is only realized by few studies, in which electron/ion-inactive self-healable substrates are utilized. This fundamentally arises from the lack of self-healable electrolytes for solid-state batteries, and therefore, results in low healing efficiency and volume/mass diseconomy...
June 15, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29905087/effects-of-tunable-keratin-hydrogel-erosion-on-rhbmp-2-release-bioactivity-and-bone-induction
#13
David Josh Cohen, Sharon L Hyzy, Salma Haque, Lucas C Olson, Barbara Boyan, Justin M Saul, Zvi Schwartz
Keratin proteins derived from human hair are known to contain a large number of cysteine residues. In hydrogels composed of oxidatively extracted keratin (keratose), sulfonic acid on the cysteine residues prevents disulfide crosslinking. Reductively extracted keratin (kerateine) has thiol groups on cysteine residues that can form disulfide crosslinks. The rates of keratin hydrogel erosion and, in some cases, drug release can be tuned by manipulating disulfide crosslinking levels via the keratose:kerateine (KOS:KTN) ratio...
June 15, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29905061/tailored-macroporous-hydrogels-with-nanoparticles-display-enhanced-and-tunable-catalytic-activity
#14
Teodora Gancheva, Nick Virgilio
This work demonstrates that a model system of poly( N-isopropylacrylamide) (PNIPAam) macroporous hydrogels, with tailored microstructures and comprising gold (Au) or silver (Ag) nanoparticles, display enhanced and tunable catalytic activity. These nanocomposites are prepared using polymer templates obtained from melt-processed cocontinuous polymer blends. The reaction rate, controlled by both hydrogel porosity and the PNIPAam lower critical solution temperature, increases by more than an order of magnitude as compared to nonporous gels, and is comparable to micro- or nanocarrier-based systems, with easier catalyst recovery...
June 15, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29904797/hyaluronic-acid-hydrogels-incorporating-platelet-lysate-enhance-human-pulp-cell-proliferation-and-differentiation
#15
Leopoldina D F Almeida, Pedro S Babo, Cristiana R Silva, Márcia T Rodrigues, Josimeri Hebling, Rui L Reis, Manuela E Gomes
The restoration of dentine-pulp complex remains a challenge for dentists; nonetheless, it has been poorly addressed. An ideal system should modulate the host response, as well as enable the recruitment, proliferation and differentiation of relevant progenitor cells. Herein was proposed a photocrosslinkable hydrogel system based on hyaluronic acid (HA) and platelet lysate (PL). PL is a cocktail of growth factors (GFs) and cytokines involved in wound healing orchestration, obtained by the cryogenic processing of platelet concentrates, and was expected to provide the HA hydrogels specific biochemical cues to enhance pulp cells' recruitment, proliferation and differentiation...
June 14, 2018: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/29904767/controlled-assembly-of-metal-colloids-on-dye-doped-silica-particles-to-tune-the-photophysical-properties-of-organic-molecules
#16
Giulia Zampini, Luigi Tarpani, Giuseppina Massaro, Marta Gambucci, Eugenio Peli, Loredana Latterini
The use of plasmonic nanomaterials is a challenging strategy to control radiation and radiation-induced processes at a nanometric scale. The localized surface plasmons of metal nanoparticles have been shown to affect the efficiency of a variety of radiative and non-radiative processes occurring in organic molecules. In this contribution, we present an overview of the results obtained through an original approach based on the hierarchical assembly of plasmonic gold colloids on silica templates, covalently doped with organic dyes...
June 15, 2018: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/29904603/nano-hydroxyapatite-polymeric-hydrogels-for-dye-removal
#17
Kokkarachedu Varaprasad, Dariela Nunez, Murali Mohan Yallapu, Tippabattini Jayaramudu, Elizabeth Elgueta, Patricio Oyarzun
Herein, two kinds of nano-hydroxyapatite were synthesized from Clam and Magellan shell by wet chemical precipitation method. Mainly, carboxymethyl cellulose/acrylamide/nano-hydroxyapatite composite hydrogels were developed via a free-radical polymerization process and investigated as a sorbent for Acid Blue 113 (AB) from aqueous AB solution. The swelled and kinetic behaviours of hydrogels were investigated using a gravimetric method. The swelling properties of the CMC-AM-hydrogels were influenced by the calcium electrolytes (Ca2+ ) content in nano-hydroxyapatites...
May 16, 2018: RSC Advances
https://www.readbyqxmd.com/read/29903998/honey-based-templates-in-wound-healing-and-tissue-engineering
#18
REVIEW
Benjamin A Minden-Birkenmaier, Gary L Bowlin
Over the past few decades, there has been a resurgence in the clinical use of honey as a topical wound treatment. A plethora of in vitro and in vivo evidence supports this resurgence, demonstrating that honey debrides wounds, kills bacteria, penetrates biofilm, lowers wound pH, reduces chronic inflammation, and promotes fibroblast infiltration, among other beneficial qualities. Given these results, it is clear that honey has a potential role in the field of tissue engineering and regeneration. Researchers have incorporated honey into tissue engineering templates, including electrospun meshes, cryogels, and hydrogels, with varying degrees of success...
June 14, 2018: Bioengineering
https://www.readbyqxmd.com/read/29903061/self-assembly-of-succinated-paclitaxel-into-supramolecular-hydrogel-for-local-cancer-chemotherapy
#19
Qianqian Song, Renshu Zhang, Lei Lei, Xingyi Li
In the present study, we reported the generation of a molecular hydrogel of succinated paclitaxel (PTX-SA) by a self-hydrolytic strategy for potential local cancer chemotherapy. Upon self-hydrolysis of the ester bond of PTX-SA in phosphate-buffered saline (pH = 7.4) for 24 h, a PTX-SA supramolecular hydrogel formed spontaneously with a minimal gelation concentration of 0.25 wt%. The formed PTX-SA supramolecular hydrogel displayed a filamentous nanostructure, the nanofibers of which were typically several micrometers in length with a diameter of 10-15 nm...
August 1, 2018: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/29903060/bifunctional-supramolecular-hydrogel-alleviates-myocardial-ischemia-reperfusion-injury-by-inhibiting-autophagy-and-apoptosis
#20
Yi Deng, Guoqin Chen, Min Ye, Yingyan He, Zehua Li, Xianbao Wang, Caiwen Ou, Zhimou Yang, Minsheng Chen
Generally, nitric oxide (NO) is an important multi-functional cardioprotective soluble gas molecule. However, it may be detrimental when in excessive levels or combined with O2- a kind of reactive oxygen species (ROS)-to form ONOO-. The latter will rapidly decompose to highly reactive oxidant components. ROS will be abundantly produced during the ischemia/reperfusion (I/R) procedure. Therefore, an NO donor coupled with another antioxidant would be a more promising strategy for I/R treatment. In this study, we report on a novel self-assembly supramolecular hydrogel capable of constantly releasing both NO and curcumin (Cur) simultaneously, and we found that the combinational treatment of Cur and NO from the gel could efficiently reduce I/R injuries...
August 1, 2018: Journal of Biomedical Nanotechnology
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