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Hydrogels

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https://www.readbyqxmd.com/read/29029265/preclinical-testing-of-a-broad-spectrum-antimicrobial-endotracheal-tube-coated-with-an-innate-immune-synthetic-mimic
#1
Marjan M Hashemi, John Rovig, Jordan Bateman, Brett S Holden, Tomasz Modelzelewski, Iliana Gueorguieva, Martin von Dyck, Ronald Bracken, Carl Genberg, Shenglou Deng, Paul B Savage
Background: Endotracheal tubes provide an abiotic surface on which bacteria and fungi form biofilms, and the release of endotoxins and planktonic organisms can cause damaging inflammation and infections. Objectives: Ceragenins are small molecule mimics of antimicrobial peptides with broad-spectrum antibacterial and antifungal activity, and a ceragenin may be used to provide antimicrobial protection to the abiotic surface of an endotracheal tube. Methods: A hydrogel film, containing CSA-131, was generated on endotracheal tubes...
October 4, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29029228/development-of-a-whole-task-simulator-for-carotid-endarterectomy
#2
Gabrielle Santangelo, Doran Mix, Ahmed Ghazi, Michael Stoner, G Edward Vates, Jonathan J Stone
BACKGROUND: Surgical education relies on operative exposure with live patients. Carotid endarterectomy (CEA) demands an experienced surgeon with a very low complication rate. The high-risk nature of this procedure and the decline in number of CEAs performed annually has created a gap in residency training. OBJECTIVE: To develop a high-fidelity whole-task simulation for CEA that demonstrates content, construct, and face validity. METHODS: Anatomically accurate models of the human neck were created using multilayered poly-vinyl alcohol hydrogels...
September 27, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29028576/bioelectrochromic-hydrogel-for-fast-antibiotic-susceptibility-testing
#3
Ferran Pujol-Vila, Jiri Dietvorst, Laura Gall-Mas, María Díaz-González, Núria Vigués, Jordi Mas, Xavier Muñoz-Berbel
Materials science offers new perspectives in the clinical analysis of antimicrobial sensitivity. However, a biomaterial with the capacity to respond to living bacteria has not been developed to date. We present an electrochromic iron(III)-complexed alginate hydrogel sensitive to bacterial metabolism, here applied to fast antibiotic-susceptibility determination. Bacteria under evaluation are entrapped -and pre-concentrated- in the hydrogel matrix by oxidation of iron (II) ions to iron (III) and in situ formation of the alginate hydrogel in less than 2min and in soft experimental conditions (i...
September 6, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29028331/ion-induced-hydrogel-formation-and-nematic-ordering-of-nanocrystalline-cellulose-suspensions
#4
Pascal Bertsch, Stéphane Isabettini, Peter Fischer
Nanocrystalline cellulose (NCC) is a promising material for formation of hydrogels and nematically ordered phases. While salt addition is known to facilitate hydrogel formation, it remains unclear whether this originates from cationic bridging or charge screening effects. Herein, we demonstrate the effect of mono- and divalent salts on NCC gelation and nematic ordering. A strong correlation of NCC suspension zeta-potential and rheological behavior was found. Lower concentrations of divalent cations were needed to decrease NCC zeta-potential and form hydrogels...
October 13, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/29028288/hypochlorous-acid-is-anti-pruritic-and-anti-inflammatory-in-a-mouse-model-of-atopic-dermatitis
#5
Tomoki Fukuyama, Britta C Martel, Keith Linder, Sarah Ehling, Joy Rachel Ganchingco, Wolfgang Bäumer
BACKGROUND: It has been reported that topical hypochlorous acid (HOCl) formulations lead to relief of itch in human patients with atopic dermatitis, however the specific anti-pruritic mechanism of action remains unclear. OBJECTIVE: To confirm itch relief and reduction of lesions in a mouse model of atopic dermatitis and to elucidate possible HOCl's mode of action. METHODS: In this study, the effects of topical administration of HOCl hydrogel (0...
October 13, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29027783/antibacterial-structural-color-hydrogel
#6
Zhuoyue Chen, Min Mo, Fanfan Fu, Luoran Shang, Huan Wang, Cihui Liu, Yuanjin Zhao
Structural color hydrogels with lasting survivability are important for many areas, while their anti-biodegradation capability is still lacking. Thus, we herein present novel antibacterial structural color hydrogels by simply synthesizing AgNPs in situ within the hydrogel materials. As the integrated AgNPs possessed wide and excellent antibacterial abilities, the structural color hydrogels could prevent bacteria adhering, avoid hydrogel damage, and maintain their vivid structural colors during application and storage...
October 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29027711/expansion-of-mesenchymal-stem-cells-on-electrospun-scaffolds-maintains-stemness-mechano-responsivity-and-differentiation-potential
#7
Su-Jin Heo, Spencer E Szczesny, Dong Hwa Kim, Kamiel S Saleh, Robert L Mauck
Mesenchymal stem cells (MSCs) hold great promise for regenerative therapies and tissue engineering applications given their multipotential differentiation capacity. However, MSC isolation and expansion are typically performed on super-physiologically stiff tissue culture plastic (TCP), which may alter their behavior and lead to unintended consequences upon implantation. In contrast, electrospun nanofibrous scaffolds possess physical and mechanical properties that are similar to that of native tissue. In this study, we investigated whether isolation and expansion of juvenile bovine MSCs directly onto electrospun nanofibrous scaffolds better preserves MSC phenotype and stemness compared to TCP...
October 13, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29027284/polydopamine-particles-reinforced-poly-vinyl-alcohol-hydrogel-with-nir-light-triggered-shape-memory-and-self-healing-capability
#8
Li Yang, Zhanhua Wang, Guoxia Fei, Hesheng Xia
This study focuses on developing a facile approach to prepare biocompatible poly(vinyl alcohol) (PVA) composite hydrogels containing polydopamine particles (PDAPs) with ultrafast near-infrared (NIR) light-triggered shape memory and self-healing capability. The PVA-PDAPs composite hydrogels with excellent mechanical properties can be achieved after freezing/thawing treatment, and the formation of physically cross-linked networks from the hydrogen bonding (H-bonding) between PVA and PDAPs. Due to the excellent photothermal effect of polydopamine, the composited hydrogel can achieve rapid shape recovery and efficient self-healing properties under NIR light exposure in a short time...
October 13, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/29026644/wet-spinning-fabrication-of-shear-patterned-alginate-hydrogel-microfibers-and-the-guidance-of-cell-alignment
#9
You Yang, Jing Sun, Xiaolu Liu, Zhenzhen Guo, Yunhu He, Dan Wei, Meiling Zhong, Likun Guo, Hongsong Fan, Xingdong Zhang
Native tissue is naturally comprised of highly-ordered cell-matrix assemblies in a multi-hierarchical way, and the nano/submicron alignment of fibrous matrix is found to be significant in supporting cellular functionalization. In this study, a self-designed wet-spinning device appended with a rotary receiving pool was used to continuously produce shear-patterned hydrogel microfibers with aligned submicron topography. The process that the flow-induced shear force reshapes the surface of hydrogel fiber into aligned submicron topography was systematically analysed...
October 2017: Regenerative Biomaterials
https://www.readbyqxmd.com/read/29026641/surface-hydrolysis-mediated-pegylation-of-poly-n-isopropyl-acrylamide-based-nanogels
#10
Jonathan T Peters, Stanley Verghese, Deepak Subramanian, Nicholas A Peppas
In this work, poly(N-isopropyl acrylamide-co-acrylamide) [P(NIPAAm-co-AAm)] nanogels were modified by hydrolysis above the lower critical solution temperature (LCST) to localize carboxylic acid functional groups at the surface (surface hydrolysis). PNIPAAm copolymerized with 15% and 20% nominal AAm in the feed were prepared and compared to equivalent hydrogels with acrylic acid. The effect and extent of surface hydrolysis was confirmed by potentiometric titration and zeta potential. These surface modified nanogels were then modified with primary amine functionalized PEG chains...
October 2017: Regenerative Biomaterials
https://www.readbyqxmd.com/read/29026640/directing-the-osteoblastic-and-chondrocytic-differentiations-of-mesenchymal-stem-cells-matrix-vs-induction-media
#11
Jing He, Jianglong Guo, Bo Jiang, Ruijuan Yao, Yao Wu, Fang Wu
While both induction culture media and matrix have been reported to regulate the stem cell fate, little is known about which factor plays a more decisive role in directing the MSC differentiation lineage as well as the underlying mechanisms. To this aim, we seeded MSCs on HA-collagen and HA-synthetic hydrogel matrixes, which had demonstrated highly different potentials toward osteoblastic and chondrocytic differentiation lineages, respectively, and cultured them with osteogenic, chondrogenic and normal culture media, respectively...
October 2017: Regenerative Biomaterials
https://www.readbyqxmd.com/read/29026426/effects-of-nanozeolite-starch-thermoplastic-hydrogels-on-wound-healing
#12
Hossein Salehi, Mohammad Mehrasa, Bijan Nasri-Nasrabadi, Mohsen Doostmohammadi, Reihaneh Seyedebrahimi, Navid Davari, Mohammad Rafienia, Mehdi E Hosseinabadi, Maria Agheb, Mansour Siavash
BACKGROUND: Wound healing is a complex biological process. Some injuries lead to chronic nonhealing ulcers, and healing process is a challenge to both the patient and the medical team. We still look forward an appropriate wound dressing. MATERIALS AND METHODS: In this study, starch-based nanocomposite hydrogel scaffolds reinforced by zeolite nanoparticles (nZ) were prepared for wound dressing. In addition, a herbal drug (chamomile extract) was added into the matrix to accelerate healing process...
2017: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/29025676/a-simple-and-efficient-feeder-free-culture-system-to-up-scale-ipscs-on-polymeric-material-surface-for-use-in-3d-bioprinting
#13
Chui-Wei Wong, You-Tzung Chen, Chung-Liang Chien, Tien-Yu Yu, Syang-Peng Rwei, Shan-Hui Hsu
The 3D bioprinting and cell/tissue printing techniques open new possibilities for future applications. To facilitate the 3D bioprinting process, a large amount of living cells are required. Induced pluripotent stem cells (iPSCs) represent a promising cell source for bioprinting. However, the maintenance and expansion of undifferentiated iPSCs are expensive and time consuming. Therefore, in this study a culture method to obtain a sufficient amount of healthy and undifferentiated iPSCs in a short-term period was established...
January 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29025662/synthesis-and-characterization-of-a-novel-double-cross-linked-hydrogel-based-on-diels-alder-click-reaction-and-coordination-bonding
#14
Shubin Li, Lu Wang, Xuemei Yu, Chengli Wang, Zhenyu Wang
Hydrogels, promising biological materials, need to have both strong mechanical properties and also inherent self-healing properties. In this work a double cross-linked network (DN) hydrogel was designed and prepared by combining a Diels-Alder click reaction and coordination effects. This DN hydrogel had good thermodynamic properties, anti-EDTA performance and self-healing properties. In addition, the mechanical properties, swelling properties and surface morphology of DN hydrogels can be controlled by adjusting the ratio of Fe(3+)-catechol...
January 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29025659/multi-responsive-hydrogels-with-ucst-and-lcst-induced-shrinking-and-controlled-release-behaviors-of-rhodamine-b
#15
Hui Sun, Jing Chen, Xia Han, Honglai Liu
By using a disulfide-functionalized crosslinker, a pH- and thermo-responsive 2-(dimethylamino) ethyl methacrylate (DMAEMA) monomer and a zwitterionic sulfobetaine methacrylate (SBMA) monomer were conjugated to fabricate a multi-responsive P(DMAEMA-SS-SBMA) copolymeric hydrogel. Apparent UCST and LCST volume transitions were observed in the P(DMAEMA-SS-SBMA) hydrogels with equivalent weight fractions of monomers. Different pore size and response sensitivity of shrunken structures below UCST and above LCST were visualized by SEM images...
January 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29025655/%C3%AE-cyclodextrin-concentration-controlled-thermo-sensitive-supramolecular-hydrogels
#16
Lin Liu, Xiangru Feng, Yueting Pei, Jinze Wang, Jianxun Ding, Li Chen
Supramolecular hydrogels (SHGs) built from inclusion complex of macrocyclic compound α-cyclodextrin (α-CD) and poly(ethylene glycol) (PEG) have attracted much interest due to their excellent biocompatibility and great potential for biomedical applications. In this work, the hydrogen bond of nucleic acid was introduced into the above-mentioned SHG by syntheses of nucleobase guanine/cytosine (G/C)-terminated PEG (G-PEG-G/C-PEG-C). The base-pairing interaction between G and C as an additional network junction effectively enhanced storage moduli (G's) of the hydrogels...
January 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29025654/3d-printing-hydrogel-with-graphene-oxide-is-functional-in-cartilage-protection-by-influencing-the-signal-pathway-of-rank-rankl-opg
#17
Zhong Cheng, Bolaky Landish, Zhang Chi, Cui Nannan, Du Jingyu, Lu Sen, Lin Xiangjin
3Dprinting is defined as the use of printing technology to deposit living cells, and biomaterials on a given /a substrate. Graphene oxide nanoparticles (GO-np) have been used as a delivery vehicle for small molecule drugs in order to investigate the state of GO-np within 3D tissue constructs in terms of a composite 3D printing scaffold, which in turn is relevant to the protection of cartilage. We transplanted rats with hydrogel/GO-np and hydrogel, which in turn showed that hydrogel/GO-np protected the tissue of cartilage by the signal pathway of Rank/Rankl/OPG...
January 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29025638/identification-of-anti-cancer-potential-of-doxazocin-loading-into-chitosan-based-biodegradable-hydrogels-for-on-site-delivery-to-treat-cervical-cancer
#18
Arshad Jamal, Lubna Shahzadi, Samreen Ahtzaz, Saba Zahid, Aqif Anwar Chaudhry, Ihtesham Ur Rehman, Muhammad Yar
In this study, an effective, biocompatible and biodegradable co-polymer comprising of chitosan (CS) and polyvinyl alcohol (PVA) hydrogels, chemically crosslinked and impregnated with doxazocin, is reported. The chemical structural properties of the hydrogels were evaluated by Fourier Transform Infrared spectroscopy (FTIR) and physical properties were analysed by scanning electron microscopy (SEM). The swelling behaviour is an important parameter for drug release mechanism and was investigated to find out the solution absorption capacity of the synthesized hydrogels...
January 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29025198/foam-dressings-for-treating-pressure-ulcers
#19
REVIEW
Rachel M Walker, Brigid M Gillespie, Lukman Thalib, Niall S Higgins, Jennifer A Whitty
BACKGROUND: Pressure ulcers, also known as pressure injuries and bed sores, are localised areas of injury to the skin or underlying tissues, or both. Dressings made from a variety of materials, including foam, are used to treat pressure ulcers. An evidence-based overview of dressings for pressure ulcers is needed to enable informed decision-making on dressing use. This review is part of a suite of Cochrane Reviews investigating the use of dressings in the treatment of pressure ulcers...
October 12, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29024487/controlling-the-release-of-small-bioactive-proteins-via-dual-mechanisms-with-therapeutic-potential
#20
Prathamesh M Kharkar, Rebecca A Scott, Laura P Olney, Paige J LeValley, Emanual Maverakis, Kristi L Kiick, April M Kloxin
Injectable delivery systems that respond to biologically relevant stimuli present an attractive strategy for tailorable drug release. Here, the design and synthesis of unique polymers are reported for the creation of hydrogels that are formed in situ and degrade in response to clinically relevant endogenous and exogenous stimuli, specifically reducing microenvironments and externally applied light. Hydrogels are formed with polyethylene glycol and heparin-based polymers using a Michael-type addition reaction...
October 12, 2017: Advanced Healthcare Materials
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