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https://www.readbyqxmd.com/read/28278185/myeloid-dendritic-cells-stimulated-by-thymic-stromal-lymphopoietin-promote-th2-immune-responses-and-the-pathogenesis-of-oral-lichen-planus
#1
Masaki Yamauchi, Masafumi Moriyama, Jun-Nosuke Hayashida, Takashi Maehara, Noriko Ishiguro, Keigo Kubota, Sachiko Furukawa, Miho Ohta, Mizuki Sakamoto, Akihiko Tanaka, Seiji Nakamura
Oral lichen planus (OLP) is a chronic inflammatory disease characterized by subepithelial T-cell infiltration. Recent studies reported that specific T helper (Th) subsets, especially Th2 cells, are involved in the pathogenesis of OLP. Thymic stromal lymphopoietin (TSLP) is mainly secreted by epithelial cells and potently activates myeloid dendritic cells (mDCs) to induce Th2-mediated inflammation. Here, we investigated the expression of TSLP and related molecules in OLP. Buccal mucosa specimens from patients with OLP, hyperkeratosis, and ulcer were analyzed by immunohistochemistry for expression of TSLP, its receptor (TSLPR), and inflammatory cells...
2017: PloS One
https://www.readbyqxmd.com/read/28274320/-circulating-levels-of-th1-and-th2-chemokines-increase-in-patients-with-early-syphilis
#2
Anyou Zhu, Chenchen Wang, Hong Sun, Hongfang Han, Fengchao Wang, Lunjun Zhang, Jianguo Hu
Objective To study the changes of plasma T helper type I (Th1)-and Th2-chemokine levels and analyze their roles in immune response and pathogenesis of early syphilis. Methods Heparin-anticoagulated peripheral blood was collected from 56 patients with early syphilis (primary syphilis, PS, n=22; secondary syphilis, SS, n=34) and healthy controls (HC, n=20). The levels of plasma Th1 chemokines including monokine induced by interferon-γ (MIG), interferon-γ inducible protein-10 (IP-10), interferon-inducible T-cell α chemoattractant (I-TAC) and Th2 chemokines including thymus-and activation-regulated chemokine (TARC), macrophage-derived chemokine (MDC) were examined using ELISA...
March 2017: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/28245475/alterations-of-serum-ip-10-and-tarc-in-patients-with-early-acute-rejection-after-liver-transplantation
#3
Xingchu Meng, Wei Gao, Ying Tang, Zhongyang Shen, Zhenglu Wang
BACKGROUND/AIMS: To analyze alterations of interferon-γ-induced protein 10 (IP-10) and thymus and activation-regulated chemokine (TARC) levels in early acute liver transplantation rejection. METHODS: Thirty-six patients with early acute liver transplantation rejection were classified as non-, mild, moderate, and severe rejection groups. The levels of serum IP-10 and TARC were determined on days 3, 2, 1, and 0 before biopsy. RESULTS: The IP-10 activities in all rejection groups were significantly higher (p < 0...
February 27, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28238403/increased-sputum-levels-of-thymus-and-activation-regulated-chemokine-in-children-with-asthma-not-eosinophilic-bronchitis
#4
M J Kim, H S Lee, I S Sol, M N Kim, J Y Hong, K E Lee, Y H Kim, K W Kim, M H Sohn, K-E Kim
BACKGROUND: Thymus and activation-regulated chemokine (TARC), a member of the CC chemokine family, plays a crucial role in Th2-specific inflammation. We aimed to determine the concentration of sputum TARC in children with asthma and eosinophilic bronchitis (EB) and its relation with eosinophilic inflammation, pulmonary function, and bronchial hyper-responsiveness. METHODS: In total, 90 children with asthma, 38 with EB, and 45 control subjects were enrolled. TARC levels were measured in sputum supernatants using an ELISA...
February 18, 2017: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/28170001/the-mcp-4-mcp-1-ratio-in-plasma-is-a-candidate-circadian-biomarker-for-chronic-post-traumatic-stress-disorder
#5
C Dalgard, O Eidelman, C Jozwik, C H Olsen, M Srivastava, R Biswas, Y Eudy, S W Rothwell, G P Mueller, P Yuan, W C Drevets, H K Manji, M Vythlingam, D S Charney, A Neumeister, R J Ursano, D M Jacobowitz, H B Pollard, O Bonne
Post-traumatic stress disorder (PTSD) is psychiatric disease, which can occur following exposure to traumatic events. PTSD may be acute or chronic, and can have a waxing and waning course of symptoms. It has been hypothesized that proinflammatory cytokines and chemokines in the cerebrospinal fluid (CSF) or plasma might be mediators of the psychophysiological mechanisms relating a history of trauma exposure to changes in behavior and mental health disorders, and medical morbidity. Here we test the cytokine/chemokine hypothesis for PTSD by examining levels of 17 classical cytokines and chemokines in CSF, sampled at 0900 hours, and in plasma sampled hourly for 24 h...
February 7, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28137259/effect-of-the-topical-application-of-an-ethanol-extract-of-quince-seeds-on-the-development-of-atopic-dermatitis-like-symptoms-in-nc-nga-mice
#6
Takeshi Kawahara, Kanako Tsutsui, Eri Nakanishi, Toshifumi Inoue, Yasunori Hamauzu
BACKGROUND: Quince (Cydonia oblonga Miller) is a deciduous shrub belonging to the Rosaceae family. Quince seed extract has long been used as a cosmetic ingredient for its moisturizing effect. However, little is known about whether quince seed extract has therapeutic effects on keratinocyte-associated skin inflammation. METHODS: In the present study, we investigated the effect of the topical application of ethanol extract of quince seeds (QSEtE) on atopic dermatitis (AD) symptoms in NC/Nga mice...
January 31, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28134765/dimerized-translationally-controlled-tumor-protein-binding-peptide-ameliorates-atopic-dermatitis-in-nc-nga-mice
#7
Xing-Hai Jin, Juhyeon Lim, Dong Hae Shin, Jeehye Maeng, Kyunglim Lee
Our previous study showed that dimerized translationally controlled tumor protein (dTCTP) plays a role in the pathogenesis of allergic diseases, such as asthma and allergic rhinitis. A 7-mer peptide, called dTCTP-binding peptide 2 (dTBP2), binds to dTCTP and inhibits its cytokine-like effects. We therefore examined the protective effects of dTBP2 in house dust mite-induced atopic dermatitis (AD)-like skin lesions in Nishiki-nezumi Cinnamon/Nagoya (NC/Nga) mice. We found that topical administration of dTBP2 significantly reduced the AD-like skin lesions formation and mast cell infiltration in NC/Nga mice, similarly to the response seen in the Protopic (tacrolimus)-treated group...
January 26, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27986411/interleukin-16-and-ccl17-thymus-and-activation-regulated-chemokine-in-patients-with-aspirin-exacerbated-respiratory-disease
#8
Luis Manuel Teran, Fernando Ramirez-Jimenez, Gabriela Soid-Raggi, Juan Raymundo Velazquez
BACKGROUND: Interleukin (IL) 16 and thymus and activation-regulated cytokine (TARC) are chemoattractant cytokines for eosinophils and TH2 cells. Differential levels of these components in aspirin-exacerbated respiratory disease (AERD) and allergic rhinitis with asthma (ARwA) may be related to a different inflammatory response in both asthma phenotypes. OBJECTIVE: To assess the nasal lavage immunoreactivity of IL-16 and TARC cytokines. METHODS: We used multienzyme-linked immunosorbent assays to detect IL-5, IL-13, IL-16, IL-33, I-309/CCL1, TARC/CCL17, monocyte-derived chemokine/CCL22, periostin, and eosinophil cationic protein levels in nasal lavages from patients with AERD and patients with ARwA...
December 13, 2016: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/27897453/clinical-usefulness-of-simultaneous-measurement-of-the-tear-levels-of-ccl17-ccl24-and-il-16-for-the-biomarkers-of-allergic-conjunctival-disorders
#9
Jun Shoji, Hiroshi Aso, Noriko Inada
PURPOSE: This study investigated the clinical usefulness of a multiple tear cytokine/chemokine test by simultaneously determining tear levels of CC chemokine ligand 17 (CCL17)/thymus and activation-regulated chemokine (TARC), CCL24/eotaxin-2, and interleukin-16 (IL-16) for assessing acute and chronic allergic inflammation in allergic conjunctival disorders (ACDs). SUBJECTS AND METHODS: This study included 37 patients with ACD and 11 healthy adults (controls). Patients with ACDs were divided into the following three groups; patients with allergic conjunctivitis (AC group, n = 17), patients with atopic keratoconjunctivitis (AKC group, n = 6), and patients with vernal keratoconjunctivitis (VKC group, n = 14)...
November 29, 2016: Current Eye Research
https://www.readbyqxmd.com/read/27847527/ma-huang-tang-suppresses-the-production-and-expression-of-inflammatory-chemokines-via-downregulating-stat1-phosphorylation-in-hacat-keratinocytes
#10
Hye-Sun Lim, Chang-Seob Seo, Seong-Eun Jin, Sae-Rom Yoo, Mee-Young Lee, Hyeun-Kyoo Shin, Soo-Jin Jeong
Ma huang tang (MHT) is a traditional herbal medicine comprising six medicinal herbs and is used to treat influenza-like illness. However, the effects of MHT on inflammatory skin diseases have not been verified scientifically. We investigated determining the inhibitory effects of MHT against inflammation responses in skin using HaCaT human keratinocyte cells. We found that MHT suppressed production of thymus and activation-regulated chemokine (TARC/CCL17), macrophage-derived chemokine (MDC/CCL22), regulated on activation of normal T-cell expressed and secreted (RANTES/CCL5), and interleukin-8 (IL-8) in tumor necrosis factor-α (TNF-α) and interferon-γ- (IFN-γ-) stimulated HaCaT cells...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27809916/immunological-profiling-of-patients-with-ulcerative-colitis-leads-to-identification-of-two-inflammatory-conditions-and-cd1a-as-a-disease-marker
#11
M Föhlinger, P Palamides, U Mansmann, F Beigel, M Siebeck, R Gropp
BACKGROUND: Conventional approaches to understand mechanisms underlying the development of pathological manifestations in ulcerative colitis (UC) mostly rely on identification of certain cell types and cytokines followed by verification of their roles in vitro and in vivo. In light of the highly dynamic processes in UC, requiring the cross talk of immune cells, epithelial-, endothelial-, muscle cells and fibrocytes, this approach might neglect temporal and spatial connectivity of individually differing inflammatory responses...
November 3, 2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27761952/wy14643-an-agonist-for-ppar%C3%AE-downregulates-expression-of-tarc-and-rantes-in-cultured-human-keratinocytes
#12
LETTER
Wei Zhang, Takashi Sakai, Sakuhei Fujiwara, Yutaka Hatano
Beneficial effects of Wy14643, an agonist for peroxisome proliferator-activated receptor (PPAR)α, on permeability barrier homeostasis-related functions of keratinocytes such as up-regulation of epidermal differentiation-related molecules and lipid synthesis, have been demonstrated. The present study demonstrated that Wy14643 reduced the expression of thymus and activation-related chemokine (TARC) and regulated on activation normal T cell expressed (RANTES) in both single- and 3D-cultured human keratinocytes...
October 20, 2016: Experimental Dermatology
https://www.readbyqxmd.com/read/27717338/estimation-of-axial-curvature-of-anterior-sclera-correlation-between-axial-length-and-anterior-scleral-curvature-as-affected-by-angle-kappa
#13
Sang-Mok Lee, Hyuk Jin Choi, Heejin Choi, Mee Kum Kim, Won Ryang Wee
BACKGROUND: Though the development and fitting of scleral contact lenses are expanding steadily, there is no simple method to provide scleral metrics for scleral contact lens fitting yet. The aim of this study was to establish formulae for estimation of the axial radius of curvature (ARC) of the anterior sclera using ocular biometric parameters that can be easily obtained with conventional devices. METHODS: A semi-automated stitching method and a computational analysis tool for calculating ARC were developed by using the ImageJ and MATLAB software...
October 7, 2016: BMC Ophthalmology
https://www.readbyqxmd.com/read/27696405/effects-of-hovenia-dulcis-thunb-extract-and-methyl-vanillate-on-atopic-dermatitis-like-skin-lesions-and-tnf-%C3%AE-ifn-%C3%AE-induced-chemokines-production-in-hacat-cells
#14
Sue Ji Lim, Myungsuk Kim, Ahmad Randy, Eui Jeong Nam, Chu Won Nho
OBJECTIVES: Here, we hypothesized that Hovenia dulcis branch extract (HDB) and its active constituents ameliorates 2,4-dinitrochlorobenzene-induced atopic dermatitis (AD)-like skin lesions by modulating the T helper Th1/Th2 balance in NC/Nga mice and TNF-α- and IFN-γ-induced production of thymus and activation-regulated chemokine (TARC) and macrophage-derived chemokine (MDC) in HaCaT cells. METHODS: HaCaT cells were stimulated by TNF-α/IFN-γ in the presence of HDB and its constituents...
November 2016: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/27650194/abnormalities-in-chemokine-levels-in-schizophrenia-and-their-clinical-correlates
#15
Suzi Hong, Ellen E Lee, Averria Sirkin Martin, Benchawanna Soontornniyomkij, Virawudh Soontornniyomkij, Cristian L Achim, Chase Reuter, Michael R Irwin, Lisa T Eyler, Dilip V Jeste
Chemokines are promising biomarkers of immune activation and inflammation, but evidence for chemokine abnormalities in schizophrenia and their relationship to clinical factors remains inconclusive. We aimed to understand chemokine-related diagnostic differences and clinical correlates using a comprehensive panel and studying a large, well-characterized sample of adults with and without schizophrenia. We studied 134 outpatients with schizophrenia or schizoaffective disorder and 112 healthy comparison (HC) individuals, 26 to 65years of age...
September 17, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27630735/inhibitory-effect-of-valencene-on-the-development-of-atopic-dermatitis-like-skin-lesions-in-nc-nga-mice
#16
In Jun Yang, Dong-Ung Lee, Heung Mook Shin
Valencene (VAL) isolated from Cyperus rotundus possesses various biological effects such as antiallergic and antimelanogenesis activity. We investigated the effect of VAL on atopic dermatitis (AD) skin lesions and their molecular mechanisms. We topically applied VAL to 1-chloro-2,4-dinitrobenzene (DNCB) sensitized NC/Nga mice. Modified scoring atopic dermatitis index, scratching behavior, and histological/immunohistochemical staining were used to monitor disease severity. RT-PCR, western blotting, and enzyme-linked immunosorbent assay were used to determine the level of IgE, proinflammatory cytokines/chemokines production, and skin barrier proteins expression...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27610595/biomarkers-for-evaluation-of-treatment-response-in-classical-hodgkin-lymphoma-comparison-of-sgalectin-1-scd163-and-scd30-with-tarc
#17
Wouter J Plattel, Zainab N D Alsada, Gustaaf W van Imhoff, Arjan Diepstra, Anke van den Berg, Lydia Visser
Soluble Galectin-1 (sGal-1, also termed LGALS1), soluble CD163 (sCD163) and soluble CD30 (sCD30) have been reported to be elevated in plasma or serum of patients with classical Hodgkin lymphoma (cHL). We aimed to determine the clinical utility of these biomarkers for evaluation of treatment response compared to thymus and activation regulated chemokine (TARC, also termed CCL17). Plasma or serum samples were prospectively collected among 103 newly diagnosed cHL patients before and after treatment. Levels of sGal-1, sCD163, sCD30 and TARC were correlated with disease characteristics and clinical treatment response...
September 9, 2016: British Journal of Haematology
https://www.readbyqxmd.com/read/27599590/anti-inflammatory-effects-of-sanguisorbae-radix-water-extract-on-the-suppression-of-mast-cell-degranulation-and-stat-1-jak-2-activation-in-bmmcs-and-hacat-keratinocytes
#18
Ju-Hye Yang, Jae-Myung Yoo, Won-Kyung Cho, Jin Yeul Ma
BACKGROUND: Sanguisorbae Radix (SR) is a well-known herbal medicine used to treat inflammatory disease and skin burns in Asia. In addition, it is used to treat many types of allergic skin diseases, including urticaria, eczema, and allergic dermatitis. SR has been reported to exhibit anti-wrinkle, anti-oxidant, and anti-contact dermatitis bioactivities. METHODS: In this study, we investigated the mechanism underlying the anti-inflammatory effects of SR water extract (WSR) using human keratinocyte (HaCaT) cells and BALB/c mouse bone marrow-derived mast cells (BMMCs)...
September 6, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27584583/stratum-corneum-tape-stripping-monitoring-of-inflammatory-mediators-in-atopic-dermatitis-patients-using-topical-therapy
#19
Sjors A Koppes, Richard Brans, Suzana Ljubojevic Hadzavdic, Monique H W Frings-Dresen, Thomas Rustemeyer, Sanja Kezic
OBJECTIVE: The aim of this study was to explore the tape strip sampling technique in the assessment of stratum corneum levels of inflammatory mediators in a clinical trial setting. METHODS: Thirty-eight inflammatory mediators were analyzed by a multiplex-assay in the stratum corneum, collected by adhesive tapes before and after 6 weeks of therapy, in mild and moderate atopic dermatitis (AD) patients (n = 90). Treatment was a ceramide- and magnesium-containing emollient...
2016: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/27558640/ramalin-isolated-from-ramalina-terebrata-attenuates-atopic-dermatitis-like-skin-lesions-in-balb-c-mice-and-cutaneous-immune-responses-in-keratinocytes-and-mast-cells
#20
Hye-Jin Park, Yeon Jeong Jang, Joung-Han Yim, Hong-Kum Lee, Suhkneung Pyo
Atopic dermatitis (AD) is a chronic inflammatory skin disease that involves eczematous skin lesions with pruritic erythematous papules. In this study, we investigated the mitigating effects of ramalin, a component of the Antarctic lichen Ramalina terebrata against AD in vivo and in vitro. Oral administration of ramalin lessened scratching behaviors and significantly reduced both serum immunoglobulin E and IL-4 levels, and mRNA levels of IL-4 and IL-10 in AD-induced Balb/c mice. In vitro, treatment with ramalin produced significantly less inflammatory chemokines and cytokines, including TARC, MCP-1, RANTES, and IL-8 in TNF-α-stimulated HaCaT cells...
December 2016: Phytotherapy Research: PTR
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