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https://www.readbyqxmd.com/read/28792717/the-relationship-between-serum-tarc-tslp-and-postn-levels-and-childhood-atopic-dermatitis
#1
Pinar Uysal, Fatih Birtekocak, Aslihan Buyukozturk Karul
BACKGROUND: The aim of the study is to evaluate the relationship between serum periostin (POSTN), thymus and activation-regulated chemokine (TARC), and thymic stromal lymphopoietin (TSLP) levels and disease severity and atopy in children with atopic dermatitis. METHODS: Sixty children with atopic dermatitis and 31 healthy controls were included in the study. The disease severity was measured by SCORAD scores. Serum POSTN, TARC, and TSLP levels were measured in all participants...
July 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28734739/serum-levels-of-squamous-cell-carcinoma-antigens-1-and-2-reflect-disease-severity-and-clinical-type-of-atopic-dermatitis-in-adult-patients
#2
Tomoko Okawa, Yukie Yamaguchi, Kenzen Kou, Junya Ono, Yoshinori Azuma, Noriko Komitsu, Yusuke Inoue, Masumi Kohno, Setsuko Matsukura, Takeshi Kambara, Shoichiro Ohta, Kenji Izuhara, Michiko Aihara
BACKGROUND: Recent studies have indicated that serum levels of squamous cell carcinoma antigen (SCCA) 1 and 2 induced by type 2 cytokines such as IL-4 and IL-13, are increased in patients with atopic dermatitis (AD). However, no clinical studies have analyzed serum levels of SCCA2 in larger series of AD patients or their association with various clinical characteristics. This study was performed to clarify whether serum levels of SCCA2 are associated with disease severity and clinical phenotypes of adult AD patients...
July 19, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28703865/identification-of-unique-proteomic-signatures-in-allergic-and-non-allergic-skin-disease
#3
Jingya Wang, Mayte Suárez-Fariñas, Yeriel Estrada, Melissa L Parker, Lydia Greenlees, Geoffrey Stephens, James Krueger, Emma Guttman-Yassky, Michael D Howell
BACKGROUND: Atopic dermatitis (AD), psoriasis (PS), and contact dermatitis (CD) are common skin diseases, characterized by barrier disruption and systemic inflammation, with unique epidermal signatures and common inflammatory pathways identified by transcriptomic profiling. This study profiled proteomic signatures in serum from subjects with AD, PS, and CD compared with healthy controls (HC). OBJECTIVE: Identify unique proteomic signatures to distinguish between inflammatory diseases with similar epidermal disruption and overlapping epithelial inflammation...
July 13, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28648978/the-thymus-and-activation-regulated-chemokine-tarc-level-in-serum-at-an-early-stage-of-a-drug-eruption-is-a-prognostic-biomarker-of-severity-of-systemic-inflammation
#4
Takayoshi Komatsu-Fujii, Yuko Chinuki, Hiroyuki Niihara, Kenji Hayashida, Masataka Ohta, Ryota Okazaki, Sakae Kaneko, Eishin Morita
BACKGROUND: In severe drug eruptions, precise evaluation of disease severity at an early stage is needed to start appropriate treatment. It is not always easy to diagnose these conditions at their early stage. In addition, there are no reported prognostic biomarkers of disease severity in drug eruptions. The aim of this study was to test whether the thymus and activation-regulated chemokine (TARC) level in serum at an early stage of a drug eruption can serve as a prognostic biomarker of systemic inflammation...
June 22, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28612506/synergistic-interactions-between-corrosion-and-wear-at-titanium-based-dental-implant-connections-a-scoping-review
#5
REVIEW
K Apaza-Bedoya, M Tarce, C A M Benfatti, B Henriques, M T Mathew, W Teughels, J C M Souza
Two-piece implant systems are mainly used in oral implantology involving an osseointegrated implant connected to an abutment, which supports prosthetic structures. It is well documented that the presence of microgaps, biofilms and oral fluids at the implant-abutment connection can cause mechanical and biological complications. The aim of this review paper was to report the degradation at the implant-abutment connection by wear and corrosion processes taking place in the oral cavity. Most of the retrieved studies evaluated the wear and corrosion (tribocorrosion) of titanium-based materials used for implants and abutments in artificial saliva...
June 14, 2017: Journal of Periodontal Research
https://www.readbyqxmd.com/read/28493293/responsiveness-to-oral-prednisolone-in-severe-asthma-is-related-to-the-degree-of-eosinophilic-airway-inflammation
#6
A R Sousa, R P Marshall, L C Warnock, S Bolton, A Hastie, F Symon, B Hargadon, H Marshall, M Richardson, C E Brightling, P Haldar, R Milone, P Chalk, R Williamson, R Panettieri, R Knowles, E R Bleecker, A J Wardlaw
BACKGROUND: Patients with severe asthma appear relatively corticosteroid resistant. Corticosteroid responsiveness is closely related to the degree of eosinophilic airway inflammation. The extent to which eosinophilic airway inflammation in severe asthma responds to treatment with systemic corticosteroids is not clear. OBJECTIVE: To relate the physiological and inflammatory response to systemic corticosteroids in asthma to disease severity and the baseline extent of eosinophilic inflammation...
May 10, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28447741/effect-of-isosecotanapartholide-isolated-from-artemisia%C3%A2-princeps-pampanini-on-il%C3%A2-33-production-and-stat%C3%A2-1-activation-in-hacat-keratinocytes
#7
Chang Taek Oh, Yu-Jin Jang, Tae-Rin Kwon, Songi Im, Soon Re Kim, Joon Seok, Gun-Yong Kim, Young-Heui Kim, Seog Kyun Mun, Beom Joon Kim
The present study aimed to investigate the anti‑inflammatory effect and mechanism of action of isosecotanapartholide (ISTP), isolated from Artemisia princeps Pampanini extract (APE). The effects of ISTP and APE on the proliferation of human keratinocytes following stimulation by tumor necrosis factor‑α/interferon‑γ were assessed. ISTP and APE downregulated the expression levels of signal transducer and activator of transcription‑1 (STAT‑1), and reduced interleukin‑33 (IL‑33) production. ISTP and APE inhibited the mRNA expression levels of thymus and activation‑regulated chemokine (TARC/CCL17) in a dose‑dependent manner...
May 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28413317/korean-red-ginseng-improves-atopic-dermatitis-like-skin-lesions-by-suppressing-expression-of-proinflammatory-cytokines-and-chemokines-in%C3%A2-vivo-and-in%C3%A2-vitro
#8
Ji-Ye Kee, Yong-Deok Jeon, Dae-Seung Kim, Yo-Han Han, Jinbong Park, Dong-Hyun Youn, Su-Jin Kim, Kwang Seok Ahn, Jae-Young Um, Seung-Heon Hong
BACKGROUND: The prevalence of allergic inflammatory diseases such as atopic dermatitis (AD), asthma, and allergic rhinitis worldwide has increased and complete recovery is difficult. Korean Red Ginseng, which is the heat-processed root of Panax ginseng Meyer, is widely and frequently used as a traditional medicine in East Asia. In this study, we investigated whether Korean Red Ginseng water extract (RGE) regulates the expression of proinflammatory cytokines and chemokines via the mitogen-activated protein kinases (MAPKs)/nuclear factor kappa B (NF-κB) pathway in allergic inflammation...
April 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/28397469/intracellular-storage-of-duffy-antigen-binding-chemokines-by-duffy-positive-red-blood-cells
#9
Ayako Yamamoto, Norihiro Saito, Shu Ogasawara, Toshihiro Shiratori, Jun Kondo, Masamichi Itoga, Hiroyuki Kayaba
BACKGROUND: Duffy antigen/chemokine receptor (DARC) is a non-signaling receptor for multiple chemokines. The role of DARC on red blood cells (RBCs) has remained elusive. The purpose of this study was to analyze selective storage of DARC-binding chemokines in RBCs. METHODS: Peripheral blood from healthy volunteers with DARC-positive blood type was collected in EDTA tubes. The concentration of DARC binding chemokines (i.e., MCP-1, RANTES, eotaxin-1, TARC, and IL-8), DARC nonbinding chemokines (i...
April 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28375674/the-inflammatory-cxc-chemokines-gro%C3%AE-high-ip-10-low-and-mig-low-in-tumor-microenvironment-can-be-used-as-new-indicators-for-non-small-cell-lung-cancer-progression
#10
Ya Cao, Haitao Huang, Zhenxin Wang, Guangbo Zhang
AIMS: To investigate the clinical significance of tumor tissue-infiltrating chemokines expression in non-small cell lung cancer (NSCLC) microenvironment. MATERIALS AND METHODS: Fresh tissue samples were acquired from 50 patients with NSCLC after operation. Then, we quantified the total protein with the BCA Protein Assay Kit and tested 13 chemotactic factors in paired samples including tumor tissues, tumor adjacent tissues, and normal tissues with the CBA Kit. RESULTS: We found that the chemokine CC subfamily of MCP-1, MIP-1α, MIP-1β, and MIP-3α and the chemokine CXC subfamily of IL-8, GROα, IP-10, and MIG expressions in tumor tissues were significantly higher than those in tumor-adjacent tissues and normal tissues...
April 4, 2017: Immunological Investigations
https://www.readbyqxmd.com/read/28373098/a-comprehensive-evaluation-of-nasal-and-bronchial-cytokines-and-chemokines-following-experimental-rhinovirus-infection-in-allergic-asthma-increased-interferons-ifn-%C3%AE-and-ifn-%C3%AE-and-type-2-inflammation-il-5-and-il-13
#11
Trevor T Hansel, Tanushree Tunstall, Maria-Belen Trujillo-Torralbo, Betty Shamji, Ajerico Del-Rosario, Jaideep Dhariwal, Paul D W Kirk, Michael P H Stumpf, Jens Koopmann, Aurica Telcian, Julia Aniscenko, Leila Gogsadze, Eteri Bakhsoliani, Luminita Stanciu, Nathan Bartlett, Michael Edwards, Ross Walton, Patrick Mallia, Toby M Hunt, Trevor L Hunt, Duncan G Hunt, John Westwick, Matthew Edwards, Onn Min Kon, David J Jackson, Sebastian L Johnston
BACKGROUND: Rhinovirus infection is a major cause of asthma exacerbations. OBJECTIVES: We studied nasal and bronchial mucosal inflammatory responses during experimental rhinovirus-induced asthma exacerbations. METHODS: We used nasosorption on days 0, 2-5 and 7 and bronchosorption at baseline and day 4 to sample mucosal lining fluid to investigate airway mucosal responses to rhinovirus infection in patients with allergic asthma (n=28) and healthy non-atopic controls (n=11), by using a synthetic absorptive matrix and measuring levels of 34 cytokines and chemokines using a sensitive multiplex assay...
May 2017: EBioMedicine
https://www.readbyqxmd.com/read/28348774/latent-infection-of-human-bocavirus-accompanied-by-flare-of-chronic-cough-fatigue-and-episodes-of-viral-replication-in-an-immunocompetent-adult-patient-cologne-germany
#12
Wolfram Windisch, Monika Pieper, Inga Ziemele, Jürgen Rockstroh, Michael Brockmann, Oliver Schildgen, Verena Schildgen
INTRODUCTION: The human bocavirus (HBoV) is a parvovirus and is associated with mild to life-threatening acute or persisting respiratory infections, frequently accompanied by further pathogens. So far, there is limited knowledge on the mechanisms of persistence, and no reports on chronic infections or latency have been published so far. CASE PRESENTATION: An immunocompetent male patient suffers from a chronic HBoV1 infection, i.e. viral DNA was detected in both serum and bronchoalveolar lavage (BAL) for >5 months without co-infections and with respiratory symptoms resolved spontaneously while receiving symptomatic treatment with montelukast and corticosteroids...
August 2016: JMM Case Reports
https://www.readbyqxmd.com/read/28347830/inhibitory-effect-of-patrinia-scabiosifolia-link-on-the-development-of-atopic-dermatitis-like-lesions-in-human-keratinocytes-and-nc-nga-mice
#13
Kyung-Jae Cha, Mi Ae Im, Ayoung Gu, Da Hye Kim, Daye Lee, Jeong Soo Lee, Ji-Sook Lee, In Sik Kim
ETHNOPHARMACOLOGICAL RELEVANCE: Atopic dermatitis (AD) is a chronic pruritic and inflammatory disease occurring in skin. Patrinia scabiosifolia Link (PS), a member of the Patrinia genus (Caprifoliaceae family), has traditionally been used in folk medicines to treat various inflammatory diseases such as acute appendicitis, ulcerative colitis, and pelvic inflammation in Korea and other parts of East Asia. AIM OF THE STUDY: This study investigated the anti-inflammatory effects of PS on AD in vitro and in vivo...
July 12, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28278185/myeloid-dendritic-cells-stimulated-by-thymic-stromal-lymphopoietin-promote-th2-immune-responses-and-the-pathogenesis-of-oral-lichen-planus
#14
Masaki Yamauchi, Masafumi Moriyama, Jun-Nosuke Hayashida, Takashi Maehara, Noriko Ishiguro, Keigo Kubota, Sachiko Furukawa, Miho Ohta, Mizuki Sakamoto, Akihiko Tanaka, Seiji Nakamura
Oral lichen planus (OLP) is a chronic inflammatory disease characterized by subepithelial T-cell infiltration. Recent studies reported that specific T helper (Th) subsets, especially Th2 cells, are involved in the pathogenesis of OLP. Thymic stromal lymphopoietin (TSLP) is mainly secreted by epithelial cells and potently activates myeloid dendritic cells (mDCs) to induce Th2-mediated inflammation. Here, we investigated the expression of TSLP and related molecules in OLP. Buccal mucosa specimens from patients with OLP, hyperkeratosis, and ulcer were analyzed by immunohistochemistry for expression of TSLP, its receptor (TSLPR), and inflammatory cells...
2017: PloS One
https://www.readbyqxmd.com/read/28274320/-circulating-levels-of-th1-and-th2-chemokines-increase-in-patients-with-early-syphilis
#15
Anyou Zhu, Chenchen Wang, Hong Sun, Hongfang Han, Fengchao Wang, Lunjun Zhang, Jianguo Hu
Objective To study the changes of plasma T helper type I (Th1)-and Th2-chemokine levels and analyze their roles in immune response and pathogenesis of early syphilis. Methods Heparin-anticoagulated peripheral blood was collected from 56 patients with early syphilis (primary syphilis, PS, n=22; secondary syphilis, SS, n=34) and healthy controls (HC, n=20). The levels of plasma Th1 chemokines including monokine induced by interferon-γ (MIG), interferon-γ inducible protein-10 (IP-10), interferon-inducible T-cell α chemoattractant (I-TAC) and Th2 chemokines including thymus-and activation-regulated chemokine (TARC), macrophage-derived chemokine (MDC) were examined using ELISA...
March 2017: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/28245475/alterations-of-serum-ip-10-and-tarc-in-patients-with-early-acute-rejection-after-liver-transplantation
#16
Xingchu Meng, Wei Gao, Ying Tang, Zhongyang Shen, Zhenglu Wang
BACKGROUND/AIMS: To analyze alterations of interferon-γ-induced protein 10 (IP-10) and thymus and activation-regulated chemokine (TARC) levels in early acute liver transplantation rejection. METHODS: Thirty-six patients with early acute liver transplantation rejection were classified as non-, mild, moderate, and severe rejection groups. The levels of serum IP-10 and TARC were determined on days 3, 2, 1, and 0 before biopsy. RESULTS: The IP-10 activities in all rejection groups were significantly higher (p < 0...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28238403/increased-sputum-levels-of-thymus-and-activation-regulated-chemokine-in-children-with-asthma-not-eosinophilic-bronchitis
#17
M J Kim, H S Lee, I S Sol, M N Kim, J Y Hong, K E Lee, Y H Kim, K W Kim, M H Sohn, K-E Kim
BACKGROUND: Thymus and activation-regulated chemokine (TARC), a member of the CC chemokine family, plays a crucial role in Th2-specific inflammation. We aimed to determine the concentration of sputum TARC in children with asthma and eosinophilic bronchitis (EB) and its relation with eosinophilic inflammation, pulmonary function, and bronchial hyper-responsiveness. METHODS: In total, 90 children with asthma, 38 with EB, and 45 control subjects were enrolled. TARC levels were measured in sputum supernatants using an ELISA...
May 2017: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/28170001/the-mcp-4-mcp-1-ratio-in-plasma-is-a-candidate-circadian-biomarker-for-chronic-post-traumatic-stress-disorder
#18
C Dalgard, O Eidelman, C Jozwik, C H Olsen, M Srivastava, R Biswas, Y Eudy, S W Rothwell, G P Mueller, P Yuan, W C Drevets, H K Manji, M Vythlingam, D S Charney, A Neumeister, R J Ursano, D M Jacobowitz, H B Pollard, O Bonne
Post-traumatic stress disorder (PTSD) is psychiatric disease, which can occur following exposure to traumatic events. PTSD may be acute or chronic, and can have a waxing and waning course of symptoms. It has been hypothesized that proinflammatory cytokines and chemokines in the cerebrospinal fluid (CSF) or plasma might be mediators of the psychophysiological mechanisms relating a history of trauma exposure to changes in behavior and mental health disorders, and medical morbidity. Here we test the cytokine/chemokine hypothesis for PTSD by examining levels of 17 classical cytokines and chemokines in CSF, sampled at 0900 hours, and in plasma sampled hourly for 24 h...
February 7, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28137259/effect-of-the-topical-application-of-an-ethanol-extract-of-quince-seeds-on-the-development-of-atopic-dermatitis-like-symptoms-in-nc-nga-mice
#19
Takeshi Kawahara, Kanako Tsutsui, Eri Nakanishi, Toshifumi Inoue, Yasunori Hamauzu
BACKGROUND: Quince (Cydonia oblonga Miller) is a deciduous shrub belonging to the Rosaceae family. Quince seed extract has long been used as a cosmetic ingredient for its moisturizing effect. However, little is known about whether quince seed extract has therapeutic effects on keratinocyte-associated skin inflammation. METHODS: In the present study, we investigated the effect of the topical application of ethanol extract of quince seeds (QSEtE) on atopic dermatitis (AD) symptoms in NC/Nga mice...
January 31, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28134765/dimerized-translationally-controlled-tumor-protein-binding-peptide-ameliorates-atopic-dermatitis-in-nc-nga-mice
#20
Xing-Hai Jin, Juhyeon Lim, Dong Hae Shin, Jeehye Maeng, Kyunglim Lee
Our previous study showed that dimerized translationally controlled tumor protein (dTCTP) plays a role in the pathogenesis of allergic diseases, such as asthma and allergic rhinitis. A 7-mer peptide, called dTCTP-binding peptide 2 (dTBP2), binds to dTCTP and inhibits its cytokine-like effects. We therefore examined the protective effects of dTBP2 in house dust mite-induced atopic dermatitis (AD)-like skin lesions in Nishiki-nezumi Cinnamon/Nagoya (NC/Nga) mice. We found that topical administration of dTBP2 significantly reduced the AD-like skin lesions formation and mast cell infiltration in NC/Nga mice, similarly to the response seen in the Protopic (tacrolimus)-treated group...
January 26, 2017: International Journal of Molecular Sciences
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