keyword
MENU ▼
Read by QxMD icon Read
search

TARC

keyword
https://www.readbyqxmd.com/read/29141920/parathyroid-hormone-related-protein-modulates-mice-mesangial-cells-inflammation-and-blunts-apoptosis-by-enhancing-cox-2-expression
#1
Mazène Hochane, Denis Raison, Catherine Coquard, Claire Béraud, Audrey Bethry, Sabrina Danilin, Thierry Massfelder, Mariette Barthelmebs
Mesangial cell (MC) injury is a prominent feature of glomerulonephritis. Activated MC secretes inflammatory mediators which induce cell apoptosis. Parathyroid hormone-related peptide (PTHrP) is a locally active cytokine that enhances cell survival and is upregulated by pro-inflammatory factors in many cell types. The aim of this study was to analyze the regulation of PTHrP expression by inflammatory cytokines, and to evaluate whether PTHrP itself acts as a pro-inflammatory and/or survival factor on male murine MC in primary culture...
November 15, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/29131300/engineered-scaffolds-and-cell-based-therapy-for-periodontal-regeneration
#2
Daniela Carmagnola, Mihai Tarce, Claudia Dellavia, Lia Rimondini, Elena M Varoni
BACKGROUND: The main objective of regenerative periodontal therapy is to completely restore the periodontal tissues lost. This review summarizes the most recent evidence in support of scaffold- and cell-based tissue engineering, which are expected to play a relevant role in next-generation periodontal regenerative therapy. METHODS: A literature search (PubMed database) was performed to analyze more recently updated articles regarding periodontal regeneration, scaffolds and cell-based technologies...
November 10, 2017: Journal of Applied Biomaterials & Functional Materials
https://www.readbyqxmd.com/read/29122406/sensitive-skin-is-highly-frequent-in-extrinsic-atopic-dermatitis-and-correlates-with-disease-severity-markers-but-not-necessarily-with-skin-barrier-impairment
#3
Tsuyoshi Yatagai, Takatoshi Shimauchi, Hayato Yamaguchi, Jun-Ichi Sakabe, Masahiro Aoshima, Shigeki Ikeya, Kazuki Tatsuno, Toshiharu Fujiyama, Taisuke Ito, Toshiyuki Ojima, Yoshiki Tokura
BACKGROUND: Sensitive skin is a condition of cutaneous hypersensitivity to environmental factors. Lactic acid stinging test (LAST) is commonly used to assess sensitive skin and composed of four distinct sensations (pain, burning sensation, itch, and crawly feeling). A link between sensitive skin and barrier dysfunction has been proposed in atopic dermatitis (AD) patients. However, clinical and laboratory factors that are associated with sensitive skin remain unelucidated. OBJECTIVE: To investigate relationship between sensitive skin and AD-associated markers...
November 2, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29065892/the-value-of-blood-cytokines-and-chemokines-in-assessing-copd
#4
Eric Bradford, Sean Jacobson, Jason Varasteh, Alejandro P Comellas, Prescott Woodruff, Wanda O'Neal, Dawn L DeMeo, Xingnan Li, Victor Kim, Michael Cho, Peter J Castaldi, Craig Hersh, Edwin K Silverman, James D Crapo, Katerina Kechris, Russell P Bowler
BACKGROUND: Blood biomarkers are increasingly used to stratify high risk chronic obstructive pulmonary disease (COPD) patients; however, there are fewer studies that have investigated multiple biomarkers and replicated in multiple large well-characterized cohorts of susceptible current and former smokers. METHODS: We used two MSD multiplex panels to measure 9 cytokines and chemokines in 2123 subjects from COPDGene and 1117 subjects from SPIROMICS. These biomarkers included: interleukin (IL)-2, IL-6, IL-8, IL-10, tumor necrosis factor (TNF)-α, interferon (IFN)-γ, eotaxin/CCL-11, eotaxin-3/CCL-26, and thymus and activation-regulated chemokine (TARC)/CCL-17...
October 24, 2017: Respiratory Research
https://www.readbyqxmd.com/read/29033822/facial-edema-in-an-elderly-man-an-unusual-presentation-of-nonepisodic-angioedema-with-eosinophilia
#5
Takashi Hashimoto, Kanako Muneta, Ken Watanabe
Nonepisodic angioedema with eosinophilia (NEAE) is a rare allergic disease with a young Japanese and East Asian female predominance. NEAE features transient, nonrecurrent angioedema and peripheral blood eosinophilia without visceral organ involvement. Angioedema in NEAE occurs on the extremities, while the trunk and face are rarely involved. Here, we report a case of NEAE affecting only the face in an 80-year-old Japanese man. He was otherwise healthy and took no medication until the sudden development of angioedema on the face...
September 2017: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29031579/cd4-cd52-lo-t-cell-expression-contributes-to-the-development-of-systemic-lupus-erythematosus
#6
Masataka Umeda, Tomohiro Koga, Kunihiro Ichinose, Takashi Igawa, Tomohito Sato, Ayuko Takatani, Toshimasa Shimizu, Shoichi Fukui, Ayako Nishino, Yoshiro Horai, Yasuko Hirai, Shin-Ya Kawashiri, Naoki Iwamoto, Toshiyuki Aramaki, Mami Tamai, Hideki Nakamura, Kazuo Yamamoto, Norio Abiru, Tomoki Origuchi, Yukitaka Ueki, Atsushi Kawakami
The cell-surface glycoprotein CD52 is widely expressed in lymphocytes. CD4(+)CD52(hi) T cells are functioning suppressor CD4(+)T cells. We investigated the role of the immune regulation of CD4(+)CD52 T cells in systemic lupus erythematosus (SLE). CD4(+)CD52(lo) T cells were increased in SLE patients, in positive correlation with SLEDAI, anti-ds-DNA antibody, and IgG concentration. Circulating follicular helper-like T cells (Tfh-like cells) were also increased in SLE, in positive correlation with CD4(+)CD52(lo) T cells...
October 13, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/29017796/anti-inflammatory-effect-of-collagen-tripeptide-in-atopic-dermatitis
#7
Amiko Hakuta, Yukie Yamaguchi, Tomoko Okawa, Shoko Yamamoto, Yasuo Sakai, Michiko Aihara
BACKGROUND: Atopic dermatitis (AD) is a chronic, pruritic inflammatory skin disease in which type 2 allergic inflammation plays an important role. Collagen tripeptide (CTP) is a functional collagen fraction with a high content of Gly-X-Y tripeptides. OBJECTIVE: To examine the effect of CTP on inflammation in AD. METHODS: Levels of inflammatory cytokines and chemokines, such as thymus- and activation-regulated chemokine (TARC), macrophage-derived chemokine, and thymic stromal lymphopoietin (TSLP), were examined in human keratinocytes supplemented with or without CTP under AD-like inflammation...
September 28, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28992524/early-reduction-of-serum-tarc-levels-may-predict-for-success-of-abvd-as-frontline-treatment-in-patients-with-hodgkin-lymphoma
#8
A Guidetti, A Mazzocchi, R Miceli, E Paterno', F Taverna, F Spina, F Crippa, L Farina, P Corradini, A M Gianni, S Viviani
BACKGROUND: Many efforts have been made to predict prognosis of newly diagnosed Hodgkin Lymphoma (HL) patients. Objective of this study was to investigate the association between early reduction of Thymus and Activation-Regulated Chemokine after the first ABVD cycle (TARC-1) and prognosis of HL patients. METHODS: Serum samples of 116 HL patients were collected at baseline, after every ABVD cycle and during follow-up. The 99th centile of TARC distribution in a group of 156 independent healthy subjects (800pg/ml) was considered as cut-off for discriminating between abnormal and normal TARC values...
November 2017: Leukemia Research
https://www.readbyqxmd.com/read/28991404/rapid-changes-in-serum-cytokines-and-chemokines-in-response-to-inactivated-influenza-vaccination
#9
Kawsar R Talaat, Neal A Halsey, Amber B Cox, Christian L Coles, Anna P Durbin, Amritha Ramakrishnan, Jay H Bream
BACKGROUND: The timing of host cytokine responses to influenza vaccination is poorly understood. OBJECTIVES: We examined serum cytokine kinetics following inactivated trivalent influenza vaccine (TIV) to better understand potential relationships between markers of inflammation and TIV-related side effects. PATIENTS/METHODS: Twenty healthy adult subjects received TIV. Cytokines/chemokines were assessed in intervals from 3 hours - 14 days. Antibody titers were measured at baseline and day 14...
October 9, 2017: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/28982899/transanal-assisted-resection-with-closure-of-anal-canal-for-lower-rectal-diseases
#10
Hidejiro Kawahara, Tadashi Akiba, Katsuhiko Yanaga
BACKGROUND/AIM: Abdominoperineal resection (APR) has been performed for lower rectal cancer, anal cancer and inflammatory diseases, but is associated with postoperative complications such as inflammation of pelvic dead space or perineal wound infection. We are performing a novel procedure (transanal assisted resection with closure of anal canal, TARC) that resects the intestine by using transanal assist and close the anal canal for patients who do not require resection of the anus and anal canal...
October 2017: Anticancer Research
https://www.readbyqxmd.com/read/28967978/topical-glucose-induces-claudin-1-and-filaggrin-expression-in-a-mouse-model-of-atopic-dermatitis-and-in-keratinocyte-culture-exerting-anti-inflammatory-effects-by-repairing-skin-barrier-function
#11
Kiyoko Yamada, Kenji Matsushita, Wang Jingshu, Takuro Kanekura
Atopic dermatitis (AD) is a chronic inflammatory skin disease. Corticosteroids, which are widely used for AD treatment, have adverse effects, and alternative treatments are urgently needed. This study examined the effect of topical application of high-dose glucose on inflamed skin in a murine model of AD. High-dose glucose treatment on the ear reduced dermatitis scores and ear thicknesses in mite antigen-treated NC/Nga mice. The levels of thymus and activation-regulated chemokine (TARC), Th cytokines (interleukin (IL)-4, IL-5, IL-12, IL-13, and (interferon) IFN-γ), and IgE were decreased in the serum of high-dose glucose-treated mice...
October 2, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28958612/apamin-inhibits-tnf-%C3%AE-and-ifn-%C3%AE-induced-inflammatory-cytokines-and-chemokines-via-suppressions-of-nf-%C3%AE%C2%BAb-signaling-pathway-and-stat-in-human-keratinocytes
#12
Woon-Hae Kim, Hyun-Jin An, Jung-Yeon Kim, Mi-Gyeong Gwon, Hyemin Gu, Sun-Jae Lee, Ji Y Park, Kyung-Duck Park, Sang-Mi Han, Min-Kyung Kim, Kwan-Kyu Park
BACKGROUND: Atopic dermatitis (AD) is identified by an increase in infiltrations of several inflammatory cells including type 2 helper (Th2) lymphocytes. Th2-related chemokines such as thymus and activation-regulated chemokine (TARC/CCL17) and macrophage-derived chemokine (MDC/CCL22), and pro-inflammatory cytokines including interleukin (IL)-1β and IL-6 are considered to play a crucial role in AD. Tumor necrosis factor (TNF)-α- and interferon (IFN)-γ induce the inflammatory condition through production of TARC, MDC, IL-1β and IL-6, and activations of related transcription factors, such as nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and signal transducer and activator of transcription (STAT) in keratinocytes...
April 18, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28949055/allopurinol-suppresses-expression-of-the-regulatory-t-cell-migration-factors-tarc-ccl17-and-mdc-ccl22-in-hacat-keratinocytes-via-restriction-of-nuclear-factor-%C3%AE%C2%BAb-activation
#13
Makoto Osabe, Toshiyuki Tajika, Masahiro Tohkin
Recent studies have shown that sparse distribution of regulatory T cells (Tregs) in the skin might be involved in the onset of severe cutaneous adverse drug reactions such as Stevens-Johnson syndrome and toxic epidermal necrolysis. Treg migration toward epithelial cells is regulated by certain chemokines, including TARC/CCL17 and MDC/CCL22. In this study, we analyzed the effect of allopurinol (APN), a drug known to cause severe adverse reactions, on the expression of factors affecting Treg migration and the mechanisms involved...
September 26, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/28932229/association-between-a-single-donor-tarc-ccl17-promotor-polymorphism-and-obstructive-chronic-lung-allograft-dysfunction-after-lung-transplantation
#14
Kevin Budding, Jessica van Setten, Eduard A van de Graaf, Oliver A van Rossum, Tineke Kardol-Hoefnagel, Erik-Jan D Oudijk, C Erik Hack, Henderikus G Otten
Lung transplantation (LTx) outcome is hampered by development of chronic rejection, often manifested as the bronchiolitis obliterans syndrome (BOS). Low serum levels of thymus and activation-regulated chemokine (TARC/CCL17), a chemoattractant, measured during the first month post-LTx are predictive for BOS development. Since TARC/CCL17 promotor polymorphisms correlate with serum TARC/CCL17 levels, we investigated seven single-nucleotide polymorphisms (SNPs) within this region and their potential association with LTx outcome...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28906043/diluted-sodium-hypochlorite-bleach-in-dogs-antiseptic-efficacy-local-tolerability-and-in-vitro-effect-on-skin-barrier-function-and-inflammation
#15
Frane Banovic, Thierry Olivry, Wolfgang Bäumer, Judy Paps, Jessica Stahl, Ana Rogers, Megan Jacob
BACKGROUND: Diluted sodium hypochlorite represents an inexpensive and widely available topical antiseptic, but there are no tolerability and efficacy data in veterinary dermatology. OBJECTIVES: To determine the in vivo antibacterial effect and tolerability of topical diluted bleach application and to assess its in vitro effect on skin barrier lipids and anti-inflammatory properties on keratinocytes. METHODS: Topical hypochlorite at 0.05% and tap water were applied to both sides of the thorax of four healthy dogs...
September 14, 2017: Veterinary Dermatology
https://www.readbyqxmd.com/read/28898872/macrophage-derived-chemokine-a-putative-marker-of-pharmacological-therapy-response-in-major-depression
#16
Vladimir M Milenkovic, Nina Sarubin, Sven Hilbert, Thomas C Baghai, Friederike Stöffler, Juan M Lima-Ojeda, André Manook, Khalifa Almeqbaali, Christian H Wetzel, Rainer Rupprecht, Caroline Nothdurfter
INTRODUCTION: Inflammatory processes play an important and complex role in the pathophysiology of major depressive disorder (MDD), but, so far, no specific investigation of chemokines exists. METHODS: In this study, we investigated the changes of plasma chemokine levels (eotaxin-1, eotaxin-3, IP-10, MCP-1, MCP-4, MDC, MIP-1α, MIP-1β, and TARC) in 47 MDD patients before (PRE) and after 1 and 6 weeks of pharmacological treatment (POST1 and POST6) in relation to the response to antidepressive therapy...
2017: Neuroimmunomodulation
https://www.readbyqxmd.com/read/28889151/hydrogen-water-ameliorates-the-severity-of-atopic-dermatitis-like-lesions-and-decreases-interleukin-1%C3%AE-interleukin-33-and-mast-cell-infiltration-in-nc-nga-mice
#17
Takuya Kajisa, Takuji Yamaguchi, Ailing Hu, Nobuhiro Suetake, Hiroyuki Kobayashi
OBJECTIVES: To examine the effect of hydrogen water (HW) on the severity of atopic dermatitis (AD) and elucidate the underlying pathophysiological mechanisms. METHODS: For this experimental study between March 2015 and December 2015, NC/Nga mice characterized by mild AD severity were given either HW (n=11) or purified water (PW) (n=9) ad libitum; specific-pathogen-free mice (n=9) were used as AD-free control. Atopic dermatitis severity score and transepidermal water loss (TEWL) were examined at baseline (0 week), and after 4 weeks of HW/PW treatment...
September 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/28873377/sea-buckthorn-hippopha%C3%A3-rhamnoides-l-oil-improves-atopic-dermatitis-like-skin-lesions-via-inhibition-of-nf-%C3%AE%C2%BAb-and-stat1-activation
#18
Dian-Dong Hou, Zheng-Hong Di, Rui-Qun Qi, He-Xiao Wang, Song Zheng, Yu-Xiao Hong, Hao Guo, Hong-Duo Chen, Xing-Hua Gao
BACKGROUND AND OBJECTIVES: The objective of this study was to evaluate the topical effects of sea buckthorn (SBT) oil on atopic dermatitis (AD)-like lesions in a mouse model generated by repeated topical administration of DNCB in BALB/c mice. METHODS: DNCB was applied repeatedly on the dorsal skin of mice to induce AD-like lesions. Following AD induction, SBT oil was applied daily on the dorsal skin for 4 weeks. The severity of skin lesions was examined macroscopically and histologically...
2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/28869080/altered-chemokine-receptor-expression-in-the-peripheral-blood-lymphocytes-in-polymyositis-and-dermatomyositis
#19
Ziwei Zhu, Chunshu Yang, Jianing Wang, Qianhui Feng, Qi Chen, Pingting Yang
OBJECTIVE: To examine the expression of chemokine receptors in different peripheral blood T-cell subsets in patients with polymyositis (PM) and dermatomyositis (DM). METHODS: We used flow cytometry to measure the frequencies of chemokinereceptors CXCR3 and CCR4 expression in the CD4(+) or CD8(+) lymphocytes. Enzyme linked immunosorbent assays were also used to measure the concentrations of C-X-C motif chemokine 10 (CXCL10), thymus and activation regulated chemokine (TARC) and macrophage derived chemokine (MDC)...
August 28, 2017: Cytokine
https://www.readbyqxmd.com/read/28792717/the-relationship-between-serum-tarc-tslp-and-postn-levels-and-childhood-atopic-dermatitis
#20
Pinar Uysal, Fatih Birtekocak, Aslihan Buyukozturk Karul
BACKGROUND: The aim of the study is to evaluate the relationship between serum periostin (POSTN), thymus and activation-regulated chemokine (TARC), and thymic stromal lymphopoietin (TSLP) levels and disease severity and atopy in children with atopic dermatitis. METHODS: Sixty children with atopic dermatitis and 31 healthy controls were included in the study. The disease severity was measured by SCORAD scores. Serum POSTN, TARC, and TSLP levels were measured in all participants...
July 1, 2017: Clinical Laboratory
keyword
keyword
75609
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"