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https://www.readbyqxmd.com/read/29666432/genetic-validation-of-bipolar-disorder-identified-by-automated-phenotyping-using-electronic-health-records
#1
Chia-Yen Chen, Phil H Lee, Victor M Castro, Jessica Minnier, Alexander W Charney, Eli A Stahl, Douglas M Ruderfer, Shawn N Murphy, Vivian Gainer, Tianxi Cai, Ian Jones, Carlos N Pato, Michele T Pato, Mikael Landén, Pamela Sklar, Roy H Perlis, Jordan W Smoller
Bipolar disorder (BD) is a heritable mood disorder characterized by episodes of mania and depression. Although genomewide association studies (GWAS) have successfully identified genetic loci contributing to BD risk, sample size has become a rate-limiting obstacle to genetic discovery. Electronic health records (EHRs) represent a vast but relatively untapped resource for high-throughput phenotyping. As part of the International Cohort Collection for Bipolar Disorder (ICCBD), we previously validated automated EHR-based phenotyping algorithms for BD against in-person diagnostic interviews (Castro et al...
April 18, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29605030/effect-of-hypertonic-saline-in-the-pretreatment-of-lung-donors-with-hemorrhagic-shock
#2
Natalia Aparecida Nepomuceno, Karina Andrighetti de Oliveira-Braga, Liliane Moreira Ruiz, Aristides Tadeu Correia, Eduardo Zinoni Silva Pato, Luiz Fernando da Silva, Paulo Manuel Pêgo-Fernandes, Marcos Naoyuki Samano
BACKGROUND: Hemorrhagic shock-induced lung edema and inflammation are two of the main reasons for the rejection of lungs donated for transplantation. Hypertonic saline (HS) induces intravascular volume expansion and has considerable immunomodulating effects that might minimize edema. Our hypothesis is based on the use of a hypertonic solution for treatment of donors who are in shock in an attempt to increase the supply of lungs for transplantation. METHODS: A total of 80 rats were allocated to four groups: one group was given an infusion of normal saline (NS; n = 20), one group received HS; n = 20, a sham group (n = 20), and a Shock group (n = 20)...
May 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29602570/successful-optimization-of-adalimumab-therapy-in-refractory-uveitis-due-to-beh%C3%A3-et-s-disease
#3
José Luis Martín-Varillas, Vanesa Calvo-Río, Emma Beltrán, Juan Sánchez-Bursón, Marina Mesquida, Alfredo Adán, María Victoria Hernandez, Marisa Hernández Garfella, Elia Valls Pascual, Lucía Martínez-Costa, Agustí Sellas-Fernández, Miguel Cordero-Coma, Manuel Díaz-Llopis, Roberto Gallego, David Salom, Norberto Ortego, José L García-Serrano, José-Luis Callejas-Rubio, José M Herreras, Ángel García-Aparicio, Olga Maíz, Ana Blanco, Ignacio Torre, David Díaz-Valle, Esperanza Pato, Elena Aurrecoechea, Miguel A Caracuel, Fernando Gamero, Enrique Minguez, Carmen Carrasco-Cubero, Alejandro Olive, Julio Vázquez, Oscar Ruiz-Moreno, Javier Manero, Santiago Muñoz-Fernández, Myriam Gandía Martinez, Esteban Rubio-Romero, F Javier Toyos-Sáenz de Miera, Francisco Javier López Longo, Joan M Nolla, Marcelino Revenga, Carmen González-Vela, Javier Loricera, Belén Atienza-Mateo, Rosalía Demetrio-Pablo, José Luis Hernández, Miguel A González-Gay, Ricardo Blanco
PURPOSE: To assess efficacy, safety, and cost-effectiveness of adalimumab (ADA) therapy optimization in a large series of patients with uveitis due to Behçet disease (BD) who achieved remission after the use of this biologic agent. DESIGN: Open-label multicenter study of ADA-treated patients with BD uveitis refractory to conventional immunosuppressants. SUBJECTS: Sixty-five of 74 patients with uveitis due to BD, who achieved remission after a median ADA duration of 6 (range, 3-12) months...
March 27, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29575137/preparation-of-canine-c-reactive-protein-serum-reference-material-a-feasibility-study
#4
Francesca Canalias, Matilde Piñeiro, Raquel Pato, Raquel Peña, Lluís Bosch, Lourdes Soler, Natalia García, Fermín Lampreave, Yolanda Saco, Anna Bassols
BACKGROUND: The availability of a species-specific reference material is essential for the harmonization of results obtained in different laboratories by different methods. OBJECTIVES: We describe the preparation of a canine C-reactive protein (cCRP) serum reference material containing purified cCRP stabilized in a serum matrix. The material can be used by manufacturers to assign values to their calibrator and control materials. METHODS: The serum matrix was obtained using blood collected from healthy dogs, stabilized and submitted for a delipidation process...
March 2018: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/29572183/tnfaip3-haploinsufficiency-is-the-cause-of-autoinflammatory-manifestations-in-a-patient-with-a-deletion-of-13mb-on-chromosome-6
#5
Clara Franco-Jarava, Hongying Wang, Andrea Martin-Nalda, de la Sierra Daniel Alvarez, Marina García-Prat, Domingo Bodet, Vicenç García-Patos, Alberto Plaja, Francesc Rudilla, Victor Rodriguez-Sureda, Laura García-Latorre, Ivona Aksentijevich, Roger Colobran, Pere Soler-Palacín
There is scarce literature about autoinflammation in syndromic patients. We describe a patient who, in addition to psychomotor and growth delay, presented with fevers, neutrophilic dermatosis, and recurrent orogenital ulcers. Comparative Genomic Hybridization (CGH) array permitted to identify a 13.13Mb deletion on chromosome 6, encompassing 53 genes, and including TNFAIP3 gene (A20). A20 is a potent inhibitor of the NF-kB signalling pathway and restricts inflammation via its deubiquitinase activity. Western blotting and immunoprecipitation assays showed decreased A20 expression and increased phosphorylation of p65 and IkBa...
March 20, 2018: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/29549319/publisher-correction-whole-genome-sequencing-in-psychiatric-disorders-the-wgspd-consortium
#6
Stephan J Sanders, Benjamin M Neale, Hailiang Huang, Donna M Werling, Joon-Yong An, Shan Dong, Goncalo Abecasis, P Alexander Arguello, John Blangero, Michael Boehnke, Mark J Daly, Kevin Eggan, Daniel H Geschwind, David C Glahn, David B Goldstein, Raquel E Gur, Robert E Handsaker, Steven A McCarroll, Roel A Ophoff, Aarno Palotie, Carlos N Pato, Chiara Sabatti, Matthew W State, A Jeremy Willsey, Steven E Hyman, Anjene M Addington, Thomas Lehner, Nelson B Freimer
In the version of this article initially published, the consortium authorship and corresponding authors were not presented correctly. In the PDF and print versions, the Whole Genome Sequencing for Psychiatric Disorders (WGSPD) consortium was missing from the author list at the beginning of the paper, where it should have appeared as the seventh author; it was present in the author list at the end of the paper, but the footnote directing readers to the Supplementary Note for a list of members was missing. In the HTML version, the consortium was listed as the last author instead of as the seventh, and the line directing readers to the Supplementary Note for a list of members appeared at the end of the paper under Author Information but not in association with the consortium name itself...
March 16, 2018: Nature Neuroscience
https://www.readbyqxmd.com/read/29525427/antifouling-paint-particles-sources-occurrence-composition-and-dynamics
#7
Sanye Soroldoni, Ítalo Braga Castro, Fiamma Abreu, Fabio Andrei Duarte, Rodrigo Brasil Choueri, Osmar Olinto Möller, Gilberto Fillmann, Grasiela Lopes Leães Pinho
Sources, occurrence, composition and dynamics of antifouling paint particles (APPs) were assessed in Patos Lagoon estuary (PLE), Southern Brazil. Ten areas including boatyards, a marina and artisanal fishing harbors were identified in the estuarine system as potential sources of APPs. The APPs generated in these areas were highly heterogeneous considering the size, shape and composition. Based on an estimate of antifouling paint usage and amount of boats in each studied area, artisanal fishing harbors could be the main source of particles to PLE...
March 2, 2018: Water Research
https://www.readbyqxmd.com/read/29412412/hospitalizations-for-diabetes-mellitus-and-the-family-health-strategy-paran%C3%A3-brazil-2000-2012
#8
Guilherme Oliveira de Arruda, Débora Berger Schmidt, Sonia Silva Marcon
The aim of this study was to identify trends in hospitalization for diabetes mellitus and their correlation with the Family Health Strategy (FHS) coverage in the state of Paraná, by Health District (HD), between 2000 and 2012. It is an ecological study based on secondary data from the Hospital Information System of the Brazilian Unified Health System and the Primary Care Department. There was downward trend for general admission rates (from 10.2 to 9.0/10,000 inhabitants), but upward trend for some HDs. No correlation was observed between admission rates and the FHS coverage for the state...
February 2018: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/29394319/the-polycomb-proteins-ring1b-and-ezh2-repress-the-tumoral-proinflammatory-function-in-metastasizing-primary-cutaneous-squamous-cell-carcinoma
#9
Eugenia Hernández-Ruiz, Agustí Toll, Irene García-Diez, Evelyn Andrades, Carla Ferrandiz-Pulido, Emili Masferrer, Mireia Yébenes, Ane Jaka, Javier Gimeno, Ramón Gimeno, Vicenç García-Patos, Ramón M Pujol, Inmaculada Hernández-Muñoz
Cutaneous squamous cell carcinoma (cSCC) is the second most common malignancy in humans and approximately 5% metastasize, usually to regional lymph nodes. Epigenetic regulation of gene expression may allow tumoral cells to acquire new functions in order to escape from the primary tumor. The aim of this study was to investigate the expression and function of proteins of the Polycomb family of epigenetic regulators in the metastatic process of cSCC. A higher expression of RING1B and EZH2 was detected by immunohistochemistry in a series of primary cSCC tumors that metastasized (MSCC) when compared to non-metastasizing cSCC (non-MSCC)...
January 31, 2018: Carcinogenesis
https://www.readbyqxmd.com/read/29377276/a-new-automated-turbidimetric-immunoassay-for-the-measurement-of-canine-c-reactive-protein
#10
Matilde Piñeiro, Raquel Pato, Lourdes Soler, Raquel Peña, Natalia García, Carlos Torrente, Yolanda Saco, Fermín Lampreave, Anna Bassols, Francesca Canalias
BACKGROUND: In dogs, as in humans, C-reactive protein (CRP) is a major acute phase protein that is rapidly and prominently increased after exposure to inflammatory stimuli. CRP measurements are used in the diagnosis and monitoring of infectious and inflammatory diseases. OBJECTIVES: The study aim was to develop and validate a turbidimetric immunoassay for the quantification of canine CRP (cCRP), using canine-specific reagents and standards. METHODS: A particle-enhanced turbidimetric immunoassay was developed...
January 29, 2018: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/29371895/computerized-auditory-training-in-students-electrophysiological-and-subjective-analysis-of-therapeutic-effectiveness
#11
Ândrea de Melo, Carolina Lisbôa Mezzomo, Michele Vargas Garcia, Eliara Pinto Vieira Biaggio
Introduction  Computerized auditory training (CAT) has been building a good reputation in the stimulation of auditory abilities in cases of auditory processing disorder (APD). Objective  To measure the effects of CAT in students with APD, with typical or atypical phonological acquisition, through electrophysiological and subjective measures, correlating them pre- and post-therapy. Methods  The sample for this study includes14 children with APD, subdivided into children with APD and typical phonological acquisition (G1), and children with APD and atypical phonological acquisition (G2)...
January 2018: International Archives of Otorhinolaryngology
https://www.readbyqxmd.com/read/29347193/pseudo-hermitian-anti-hermitian-ensemble-of-gaussian-matrices
#12
G Marinello, M P Pato
It is shown that the ensemble of pseudo-Hermitian Gaussian matrices recently introduced gives rise in a certain limit to an ensemble of anti-Hermitian matrices whose eigenvalues have properties directly related to those of the chiral ensemble of random matrices.
July 2017: Physical Review. E
https://www.readbyqxmd.com/read/29316968/improving-the-interoperability-of-biomedical-ontologies-with-compound-alignments
#13
Daniela Oliveira, Catia Pesquita
BACKGROUND: Ontologies are commonly used to annotate and help process life sciences data. Although their original goal is to facilitate integration and interoperability among heterogeneous data sources, when these sources are annotated with distinct ontologies, bridging this gap can be challenging. In the last decade, ontology matching systems have been evolving and are now capable of producing high-quality mappings for life sciences ontologies, usually limited to the equivalence between two ontologies...
January 9, 2018: Journal of Biomedical Semantics
https://www.readbyqxmd.com/read/29304065/bilateral-theta-burst-magnetic-stimulation-influence-on-event-related-brain-potentials
#14
RANDOMIZED CONTROLLED TRIAL
Nuno Pinto, Marta Duarte, Helena Gonçalves, Ricardo Silva, Jorge Gama, Maria Vaz Pato
Theta-burst stimulation (TBS) can be a non-invasive technique to modulate cognitive functions, with promising therapeutic potential, but with some contradictory results. Event related potentials are used as a marker of brain deterioration and can be used to evaluate TBS-related cognitive performance, but its use remains scant. This study aimed to study bilateral inhibitory and excitatory TBS effects upon neurocognitive performance of young healthy volunteers, using the auditory P300' results. Using a double-blind sham-controlled study, 51 healthy volunteers were randomly assigned to five different groups, two submitted to either excitatory (iTBS) or inhibitory (cTBS) stimulation over the left dorsolateral pre-frontal cortex (DLPFC), two other actively stimulated the right DLPFC and finally a sham stimulation group...
2018: PloS One
https://www.readbyqxmd.com/read/29291383/genetic-profiles-of-squamous-cell-carcinomas-associated-with-recessive-dystrophic-epidermolysis-bullosa-unveil-notch-and-tp53-mutations-and-an-increased-myc-expression
#15
Lidia Sans-DeSanNicolas, Ginevra Caratú, Oriol Vidal-Cortés, Sara Sanchez-Redondo, Berta Ferrer, Francesco Mancuso, Elena González-Sanchez, Mileidys Pérez-Alea, Kimberly McGrail, Javier Hernandez-Losa, Domingo Bodet, Ana Vivancos, Vicente Garcia-Patos, Juan Angel Recio
No abstract text is available yet for this article.
December 29, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29245731/a-new-annual-fish-of-the-genus-i-austrolebias-i-cyprinodontiformes-rivulidae-from-rio-camaqu%C3%A3-basin-laguna-dos-patos-system-brazilian-pampa
#16
Matheus Vieira Volcan, Ândrio Cardozo Gonçalves, Luis Esteban Krause Lanés
A new species of Austrolebias is described from the middle course of the Rio Camaquã, Laguna dos Patos system, Rio Grande do Sul, Brazil. The new species belongs to the Austrolebias alexandri species group, which is distinguished from the remaining congeners by the presence of a dark gray pectoral fin with bright blue iridescence in males. The new species is distinguished from all remaining species of the A. alexandri species group by the following combination of characters: presence of well-defined bright blue bars on the flank in males, shorter caudal fin length in males and females, contact organs in the first three rays of the pectoral fin in males, one to two post-optic neuromasts (rarely three), basihyal width of 50% of the length, and basihyal cartilage about 50-60% of the basihyal length...
October 24, 2017: Zootaxa
https://www.readbyqxmd.com/read/29241207/disease-remission-in-children-and-adolescents-with-intermediate-uveitis-a-survival-analysis
#17
Lara Borrego-Sanz, Lydia Abásolo, Consuelo López-Abad, Benjamín Fernández-Gutiérrez, Julián García-Feijoo, David Diaz-Valle, Esperanza Pato, Luis Rodriguez-Rodriguez
PURPOSE: To report the incidence rate (IR) of remission in pediatric noninfectious intermediate uveitis (IU). METHODS: Longitudinal retrospective cohort study, including 19 patients (32 eyes) between 1985 and 2014, followed-up until loss or January 2016. Remission was defined following the Standardization of Uveitis Nomenclature workshop criteria, prolonged remission as a remission spanning 12 months and until the end of follow-up, and relapse as recurrence of inflammatory activity in an eye in remission...
2018: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/29241066/agronomic-efficiency-of-phosphate-fertilizers-produced-by-the-re-use-of-a-metallurgical-acid-residue
#18
Matheus Sampaio Carneiro Barreto, Edson Marcio Mattiello, Wedisson Oliveira Santos, Leônidas Carrijo Azevedo Melo, Leonardus Vergütz, Roberto Ferreira Novais
The production of fertilizers with industrial wastes reduces the environmental impacts of waste disposal and improves environmental sustainability by generating added-value products. Our objective with this study was to evaluate the agronomic performance and potential soil/plant contamination with heavy metals of alternative phosphate (P) fertilizers, obtained from the acidulation of phosphate rocks (PR) by a metallurgical acidic waste. Seven P fertilizers were evaluated: three PR (Araxá, Patos, and Bayóvar), their respective acidulated products (PAPR), and triple superphosphate fertilizer (TSP)...
February 15, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29184211/whole-genome-sequencing-in-psychiatric-disorders-the-wgspd-consortium
#19
Stephan J Sanders, Benjamin M Neale, Hailiang Huang, Donna M Werling, Joon-Yong An, Shan Dong, Goncalo Abecasis, P Alexander Arguello, John Blangero, Michael Boehnke, Mark J Daly, Kevin Eggan, Daniel H Geschwind, David C Glahn, David B Goldstein, Raquel E Gur, Robert E Handsaker, Steven A McCarroll, Roel A Ophoff, Aarno Palotie, Carlos N Pato, Chiara Sabatti, Matthew W State, A Jeremy Willsey, Steven E Hyman, Anjene M Addington, Thomas Lehner, Nelson B Freimer
No abstract text is available yet for this article.
December 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/29157336/dissociated-components-of-executive-control-in-acute-hypobaric-hypoxia
#20
Endre Takács, István Czigler, Lívia Gabriella Pató, László Balázs
INTRODUCTION: The neurocognitive effects of acute hypobaric hypoxia are still largely unknown. This study was designed to test the hypothesis that executive control, an important component of cognition, is especially vulnerable to hypoxia. METHODS: Subjects participated in a simulated hypobaric chamber flight to 5500 m. Four auditory tasks were presented before, during, and after hypoxia: 1) Voice, and 2) Name variant of the Stroop task (both measuring conflict resolution); 3) go/no-go task (GNG; measuring inhibition); and 4) two-choice reaction time task (CRT; which is a noninhibitory control task)...
December 1, 2017: Aerospace Medicine and Human Performance
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