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Maria Ubals, Anna Castany, Patricia Bassas, Jordi Mollet, Gloria Aparicio, Vicente García-Patos
No abstract text is available yet for this article.
October 14, 2016: Journal of Pediatrics
Luis Rodriguez-Rodriguez, Leticia Leon, Jose Ivorra-Cortes, Alejandro Gómez, Jose Ramon Lamas, Esperanza Pato, Juan Angel Jover, Lydia Abásolo
OBJECTIVES: To assess the mortality rate (MR) and the mortality risk of a rheumatoid arthritis (RA) inception cohort, with and without biologic agents (BAs). Other factors associated to mortality were also investigated. METHODS: Retrospective longitudinal study of RA patients, attending the rheumatology outpatient clinic of a tertiary Hospital (Madrid), collected over 5 years (2000-2004), and followed from the diagnosis of RA up to the patients' death, lost to follow-up or September 2013...
October 7, 2016: Clinical and Experimental Rheumatology
Pedro J Sanches Filho, Emerson M Böhm, Giani M B Böhm, Gissele O Montenegro, Lucas A Silveira, Glauco R Betemps
A high concentration of hydrocarbons in the environment is indicative of pollution. To evaluate the effect of hydrocarbons transported by urban runoff, the present study analyzed total petroleum hydrocarbons (TPHs), aliphatic hydrocarbons (AHs), unresolved complex mixture (UCM), and n-alkanes of the sediments of the canal that cross the urban area of Pelotas, Rio Grande do Sul, Brazil. The carbon preference index (CPI), terrigenous/aquatic ratio (TAR), and pristane/phytane ratio were determined. The TPH content ranged from 177,043...
October 11, 2016: Marine Pollution Bulletin
Vanesa Calvo-Río, Ricardo Blanco, Montserrat Santos-Gómez, David Díaz-Valle, Esperanza Pato, Javier Loricera, María C González-Vela, Rosalía Demetrio-Pablo, José L Hernández, Miguel A González-Gay
PURPOSE: To evaluate tocilizumab (TCZ) efficacy in severe and refractory birdshot chorioretinopathy (BSCR). METHODS: Assessment of BSCR patients refractory to conventional immunosuppressive and anti-TNF-α drugs who underwent TCZ therapy. RESULTS: Two HLA-A29 positive patients (man/37 years and woman/38 years; four affected eyes) with BSCR were studied. They had a chronic bilateral posterior uveitis. Patient 1 had been treated with intraocular and oral corticosteroids, cyclosporine A, and infliximab whereas Patient 2 received intravenous methylprednisolone pulses, cyclosporine A, azathioprine, and adalimumab...
October 11, 2016: Ocular Immunology and Inflammation
Vinayak Singh, Stefano Donini, Angela Pacitto, Claudia Sala, Ruben C Hartkoorn, Neeraj Dhar, Gyorgy Keri, David B Ascher, Guillaume Mondésert, Anthony Vocat, Andréanne Lupien, Raphael Sommer, Hélène Vermet, Sophie Lagrange, Joe Buechler, Digby F Warner, John D McKinney, Janos Pato, Stewart T Cole, Tom L Blundell, Menico Rizzi, Valerie Mizrahi
VCC234718, a molecule with growth inhibitory activity against Mycobacterium tuberculosis (Mtb), was identified by phenotypic screening of a 15344-compound library. Sequencing of a VCC234718-resistant mutant identified a Y487C substitution in the inosine monophosphate dehydrogenase, GuaB2, which was subsequently validated to be the primary molecular target of VCC234718 in Mtb. VCC234718 inhibits Mtb GuaB2 with a Ki of 100 nM and is uncompetitive with respect to IMP and NAD(+). This compound binds at the NAD(+) site, after IMP has bound, and makes direct interactions with IMP; therefore, the inhibitor is by definition uncompetitive...
September 8, 2016: ACS Infectious Diseases
Vinayak Singh, Neeraj Dhar, János Pató, Gaëlle S Kolly, Jana Korduláková, Martin Forbak, Joanna C Evans, Rita Székely, Jan Rybniker, Zuzana Palčeková, Júlia Zemanová, Isabella Santi, François Signorino-Gelo, Liliana Rodrigues, Anthony Vocat, Adrian S Covarrubias, Monica G Rengifo, Kai Johnsson, Sherry Mowbray, Joseph Buechler, Vincent Delorme, Priscille Brodin, Graham W Knott, José A Aínsa, Digby F Warner, György Kéri, Katarína Mikušová, John D McKinney, Stewart T Cole, Valerie Mizrahi, Ruben C Hartkoorn
There is an urgent need to discover new anti-tubercular agents with novel mechanisms of action in order to tackle the scourge of drug-resistant tuberculosis. Here, we report the identification of such a molecule - an AminoPYrimidine-Sulfonamide (APYS1) that has potent, bactericidal activity against M. tuberculosis. Mutations in APYS1-resistant M. tuberculosis mapped exclusively to wag31, a gene that encodes a scaffolding protein thought to orchestrate cell elongation. Recombineering confirmed that a Gln201Arg mutation in Wag31 was sufficient to cause resistance to APYS1, however, neither overexpression nor conditional depletion of wag31 impacted M...
September 28, 2016: Molecular Microbiology
A Pato-Pato, L Midaglia, E Costa-Arpin, A Rodriguez-Regal, A Puy-Nunez, M Rodriguez-Rodriguez, A Lopez-Real, M A Llaneza-Gonzalez, D A Garcia-Estevez, M J Moreno-Carretero, D Escriche-Jaime, M L Aguado-Valcarcel, D Munoz, J M Prieto, J R Lorenzo-Gonzalez, M C Amigo-Jorrin
INTRODUCTION: The effectiveness and safety of fingolimod in patients with relapsing-remitting multiple sclerosis (RRMS) have been proven in clinical trials. Yet, due to their limitations, it is important to know how it behaves under everyday clinical practice conditions. Hence, the aim of this study is to evaluate the effectiveness and safety of fingolimod after 12 months' usage in clinical practice in Galicia. PATIENTS AND METHODS: We conducted a retrospective, multi-centre study (n = 8) of patients with RRMS who were treated with one or more doses of fingolimod, 0...
September 5, 2016: Revista de Neurologia
Courtney J Pokrzywa, Christina M Papageorge, Gregory D Kennedy
BACKGROUND: Preoperative urinary tract infection (UTI) may be associated with surgical site infections secondary to hematogenous spread of bacteria. The association between preoperative UTI and postoperative complications has not been evaluated in general surgery populations. MATERIALS AND METHODS: Patients undergoing elective general surgery procedures from 2011 to 2013 were selected from the American College of Surgeons National Surgical Quality Improvement Program database...
September 2016: Journal of Surgical Research
G Marinello, M P Pato
It is shown how pseudo-Hermiticity, a necessary condition satisfied by operators of PT symmetric systems can be introduced in the three Gaussian classes of random matrix theory. The model describes transitions from real eigenvalues to a situation in which, apart from a residual number, the eigenvalues are complex conjugate.
July 2016: Physical Review. E
Shane McCarthy, Sayantan Das, Warren Kretzschmar, Olivier Delaneau, Andrew R Wood, Alexander Teumer, Hyun Min Kang, Christian Fuchsberger, Petr Danecek, Kevin Sharp, Yang Luo, Carlo Sidore, Alan Kwong, Nicholas Timpson, Seppo Koskinen, Scott Vrieze, Laura J Scott, He Zhang, Anubha Mahajan, Jan Veldink, Ulrike Peters, Carlos Pato, Cornelia M van Duijn, Christopher E Gillies, Ilaria Gandin, Massimo Mezzavilla, Arthur Gilly, Massimiliano Cocca, Michela Traglia, Andrea Angius, Jeffrey C Barrett, Dorrett Boomsma, Kari Branham, Gerome Breen, Chad M Brummett, Fabio Busonero, Harry Campbell, Andrew Chan, Sai Chen, Emily Chew, Francis S Collins, Laura J Corbin, George Davey Smith, George Dedoussis, Marcus Dorr, Aliki-Eleni Farmaki, Luigi Ferrucci, Lukas Forer, Ross M Fraser, Stacey Gabriel, Shawn Levy, Leif Groop, Tabitha Harrison, Andrew Hattersley, Oddgeir L Holmen, Kristian Hveem, Matthias Kretzler, James C Lee, Matt McGue, Thomas Meitinger, David Melzer, Josine L Min, Karen L Mohlke, John B Vincent, Matthias Nauck, Deborah Nickerson, Aarno Palotie, Michele Pato, Nicola Pirastu, Melvin McInnis, J Brent Richards, Cinzia Sala, Veikko Salomaa, David Schlessinger, Sebastian Schoenherr, P Eline Slagboom, Kerrin Small, Timothy Spector, Dwight Stambolian, Marcus Tuke, Jaakko Tuomilehto, Leonard H Van den Berg, Wouter Van Rheenen, Uwe Volker, Cisca Wijmenga, Daniela Toniolo, Eleftheria Zeggini, Paolo Gasparini, Matthew G Sampson, James F Wilson, Timothy Frayling, Paul I W de Bakker, Morris A Swertz, Steven McCarroll, Charles Kooperberg, Annelot Dekker, David Altshuler, Cristen Willer, William Iacono, Samuli Ripatti, Nicole Soranzo, Klaudia Walter, Anand Swaroop, Francesco Cucca, Carl A Anderson, Richard M Myers, Michael Boehnke, Mark I McCarthy, Richard Durbin
We describe a reference panel of 64,976 human haplotypes at 39,235,157 SNPs constructed using whole-genome sequence data from 20 studies of predominantly European ancestry. Using this resource leads to accurate genotype imputation at minor allele frequencies as low as 0.1% and a large increase in the number of SNPs tested in association studies, and it can help to discover and refine causal loci. We describe remote server resources that allow researchers to carry out imputation and phasing consistently and efficiently...
October 2016: Nature Genetics
I López-Lerma, B Ferrer, I Zarzoso, J Hernández-Losa, V García-Patos
The Hedgehog (Hh) pathway has a critical role in embryogenesis.(1) Hh signaling remains active in a more limited extent throughout the life with a key role in the somatic stem cell populations through modulation of self-renewal activity. Moreover, Hh signaling is aberrantly activated in a number of malignancies and the most common way to target this pathway is modulate Smoothened (SMO).(1,2) A 79-year-old Caucasian man presented with a 3-month history of erythematous papules and hyperkeratotic lesions over the face...
August 11, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
Ingrid Lopez-Lerma, Alexandra Navarro, Vicente García-Patos
No abstract text is available yet for this article.
August 10, 2016: International Journal of Dermatology
Vinicius A Bertaco, Juliano Ferrer, Fernando R Carvalho, Luiz R Malabarba
We herein analyse the history of the description of the freshwater fish fauna from three drainages in one of the most densely collected areas of Brazil, and possibly of South America, the Rio Grande do Sul State, southern Brazil. An updated inventory of the freshwater fish species from rio Uruguay (partial) in Brazil, Laguna dos Patos (complete) and rio Tramandaí basins (complete) is presented. We found the number of new species described in these drainages increased nearly 56% since 1981, reaching a total of 422 species, but even now 10% of this number still corresponds to undescribed species...
2016: Zootaxa
Pierpaolo Vivo, Mauricio P Pato, Gleb Oshanin
We analyze the properties of entangled random pure states of a quantum system partitioned into two smaller subsystems of dimensions N and M. Framing the problem in terms of random matrices with a fixed-trace constraint, we establish, for arbitrary N≤M, a general relation between the n-point densities and the cross moments of the eigenvalues of the reduced density matrix, i.e., the so-called Schmidt eigenvalues, and the analogous functionals of the eigenvalues of the Wishart-Laguerre ensemble of the random matrix theory...
May 2016: Physical Review. E
Lydia Abásolo, Zulema Rosales, David Díaz-Valle, Alejandro Gómez-Gómez, Rayma C Peña-Blanco, Ángela Prieto-García, José Manuel Benítez-Del-Castillo, Esperanza Pato, Julián García-Feijoo, Benjamín Fernández-Gutiérrez, Luis Rodriguez-Rodriguez
PURPOSE: To assess in uveitis patients the rate of immunosuppressive drug (ISD) discontinuation in real-life clinical practice, comparing this rate among ISDs. DESIGN: Longitudinal retrospective cohort study. METHODS: We included uveitis patients attending a tertiary eye referral center from Madrid (Spain) between 1989 and 2015, prescribed any ISDs (cyclosporine, methotrexate, azathioprine, anti-TNF drugs, or others). Our main outcome was discontinuation of all ISDs owing to clinical efficacy, inefficacy, adverse drug reaction (ADR), and other medical causes...
September 2016: American Journal of Ophthalmology
N F Fontoura, J P Vieira, F G Becker, L R Rodrigues, L R Malabarba, U H Schulz, O O Möller, A M Garcia, F S Vilella
The Patos Lagoon basin is a large (201 626 km(2) ) and complex drainage system in southern Brazil. The lagoon is 250 km long and 60 km wide, covering an area of 10 360 km(2) . The exchange of water with the Atlantic Ocean occurs through a 0·8 km wide and 15 m deep inlet, fixed by 4 km long jetties, at the southernmost part of the Patos Lagoon. The estuarine area is restricted to its southern portion (10%), although the upper limit of saline waters migrates seasonally and year to year, influenced by the wind regime and river discharge...
July 2016: Journal of Fish Biology
Gábor Sirokmány, Anna Pató, Melinda Zana, Ágnes Donkó, Adrienn Bíró, Péter Nagy, Miklós Geiszt
Stimulation of mammalian cells by epidermal growth factor (EGF) elicits complex signaling events, including an increase in hydrogen peroxide (H2O2) production. Understanding the significance of this response is limited by the fact that the source of EGF-induced H2O2 production is unknown. Here we show that EGF-induced H2O2 production in epidermal cell lines is dependent on the agonist-induced calcium signal. We analyzed the expression of NADPH oxidase isoforms and found both A431 and HaCaT cells to express the calcium-sensitive NADPH oxidase, Dual oxidase 1 (Duox1) and its protein partner Duox activator 1 (DuoxA1)...
August 2016: Free Radical Biology & Medicine
G Ceni, N F Fontoura, H N Cabral
In this study data relative to the fishery in the freshwater area of the Patos Lagoon are analysed, and the dynamics, fishing gears used and catches evaluated. The results reveal the existence of two fishery strategies: forbidden mesh size gillnets (FMG; <35 mm; square measure) and allowed mesh size gillnets (AMG; ≥35 mm; square measure). In total, 31 species were caught (AMG = 27 and FMG = 24), but selectivity due to mesh size was significant (P < 0·001). The FMG may be very harmful since it captures individuals of most species below size at first maturity, including the target species, the armoured catfish Loricariichthys anus (61% of the total catch)...
July 2016: Journal of Fish Biology
Rafael A Marinho, Eduardo B Beserra, Maria A Bezerra-Gusmão, Valbia de S Porto, Ricardo A Olinda, Carlos A C Dos Santos
The mosquito Aedes aegypti is the primary vector of dengue and is common throughout tropical and subtropical regions. Its distribution is modulated by environmental factors, such as temperature. This study aimed to evaluate the influence of temperature on the life cycle and expansion of Ae. aegypti populations in the cities of Campina Grande, João Pessoa, and Patos. Samples of Ae. aegypti were collected in the three cities and raised in the laboratory. We assessed the life cycles of the three Ae. aegypti populations under six constant temperatures (16, 22, 28, 33, 36, and 39°C), selected on the basis of historical temperature tendencies of each city...
June 2016: Journal of Vector Ecology: Journal of the Society for Vector Ecology
Aaron D Besterman, Jody K Williams, Victor I Reus, Michele T Pato, Susan M Voglmaier, Carol A Mathews
OBJECTIVE: For psychiatry research resident career development, there is a recognized need for improved cross-institutional mentoring and networking opportunities. One method to address this need is via regional conferences, open to current and recently graduated research residents and their mentors. With this in mind, we developed the biennial California Psychiatry Research Resident Retreat (CPRRR) and collected feedback from participants to 1) Assess resident satisfaction, 2) Determine the utility of the retreat as a networking and mentorship tool, and 3) Identify areas for improvement...
May 13, 2016: Academic Psychiatry
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