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https://www.readbyqxmd.com/read/29412412/hospitalizations-for-diabetes-mellitus-and-the-family-health-strategy-paran%C3%A3-brazil-2000-2012
#1
Guilherme Oliveira de Arruda, Débora Berger Schmidt, Sonia Silva Marcon
The aim of this study was to identify trends in hospitalization for diabetes mellitus and their correlation with the Family Health Strategy (FHS) coverage in the state of Paraná, by Health District (HD), between 2000 and 2012. It is an ecological study based on secondary data from the Hospital Information System of the Brazilian Unified Health System and the Primary Care Department. There was downward trend for general admission rates (from 10.2 to 9.0/10,000 inhabitants), but upward trend for some HDs. No correlation was observed between admission rates and the FHS coverage for the state...
February 2018: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/29394319/the-polycomb-proteins-ring1b-and-ezh2-repress-the-tumoral-proinflammatory-function-in-metastasizing-primary-cutaneous-squamous-cell-carcinoma
#2
Eugenia Hernández-Ruiz, Agustí Toll, Irene García-Diez, Evelyn Andrades, Carla Ferrandiz-Pulido, Emili Masferrer, Mireia Yébenes, Ane Jaka, Javier Gimeno, Ramón Gimeno, Vicenç García-Patos, Ramón M Pujol, Inmaculada Hernández-Muñoz
Cutaneous squamous cell carcinoma (cSCC) is the second most common malignancy in humans and approximately 5% metastasize, usually to regional lymph nodes. Epigenetic regulation of gene expression may allow tumoral cells to acquire new functions in order to escape from the primary tumor. The aim of this study was to investigate the expression and function of proteins of the Polycomb family of epigenetic regulators in the metastatic process of cSCC. A higher expression of RING1B and EZH2 was detected by immunohistochemistry in a series of primary cSCC tumors that metastasized (MSCC) when compared to non-metastasizing cSCC (non-MSCC)...
January 31, 2018: Carcinogenesis
https://www.readbyqxmd.com/read/29377276/a-new-automated-turbidimetric-immunoassay-for-the-measurement-of-canine-c-reactive-protein
#3
Matilde Piñeiro, Raquel Pato, Lourdes Soler, Raquel Peña, Natalia García, Carlos Torrente, Yolanda Saco, Fermín Lampreave, Anna Bassols, Francesca Canalias
BACKGROUND: In dogs, as in humans, C-reactive protein (CRP) is a major acute phase protein that is rapidly and prominently increased after exposure to inflammatory stimuli. CRP measurements are used in the diagnosis and monitoring of infectious and inflammatory diseases. OBJECTIVES: The study aim was to develop and validate a turbidimetric immunoassay for the quantification of canine CRP (cCRP), using canine-specific reagents and standards. METHODS: A particle-enhanced turbidimetric immunoassay was developed...
January 29, 2018: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/29371895/computerized-auditory-training-in-students-electrophysiological-and-subjective-analysis-of-therapeutic-effectiveness
#4
Ândrea de Melo, Carolina Lisbôa Mezzomo, Michele Vargas Garcia, Eliara Pinto Vieira Biaggio
Introduction  Computerized auditory training (CAT) has been building a good reputation in the stimulation of auditory abilities in cases of auditory processing disorder (APD). Objective  To measure the effects of CAT in students with APD, with typical or atypical phonological acquisition, through electrophysiological and subjective measures, correlating them pre- and post-therapy. Methods  The sample for this study includes14 children with APD, subdivided into children with APD and typical phonological acquisition (G1), and children with APD and atypical phonological acquisition (G2)...
January 2018: International Archives of Otorhinolaryngology
https://www.readbyqxmd.com/read/29347193/pseudo-hermitian-anti-hermitian-ensemble-of-gaussian-matrices
#5
G Marinello, M P Pato
It is shown that the ensemble of pseudo-Hermitian Gaussian matrices recently introduced gives rise in a certain limit to an ensemble of anti-Hermitian matrices whose eigenvalues have properties directly related to those of the chiral ensemble of random matrices.
July 2017: Physical Review. E
https://www.readbyqxmd.com/read/29316968/improving-the-interoperability-of-biomedical-ontologies-with-compound-alignments
#6
Daniela Oliveira, Catia Pesquita
BACKGROUND: Ontologies are commonly used to annotate and help process life sciences data. Although their original goal is to facilitate integration and interoperability among heterogeneous data sources, when these sources are annotated with distinct ontologies, bridging this gap can be challenging. In the last decade, ontology matching systems have been evolving and are now capable of producing high-quality mappings for life sciences ontologies, usually limited to the equivalence between two ontologies...
January 9, 2018: Journal of Biomedical Semantics
https://www.readbyqxmd.com/read/29304065/bilateral-theta-burst-magnetic-stimulation-influence-on-event-related-brain-potentials
#7
Nuno Pinto, Marta Duarte, Helena Gonçalves, Ricardo Silva, Jorge Gama, Maria Vaz Pato
Theta-burst stimulation (TBS) can be a non-invasive technique to modulate cognitive functions, with promising therapeutic potential, but with some contradictory results. Event related potentials are used as a marker of brain deterioration and can be used to evaluate TBS-related cognitive performance, but its use remains scant. This study aimed to study bilateral inhibitory and excitatory TBS effects upon neurocognitive performance of young healthy volunteers, using the auditory P300' results. Using a double-blind sham-controlled study, 51 healthy volunteers were randomly assigned to five different groups, two submitted to either excitatory (iTBS) or inhibitory (cTBS) stimulation over the left dorsolateral pre-frontal cortex (DLPFC), two other actively stimulated the right DLPFC and finally a sham stimulation group...
2018: PloS One
https://www.readbyqxmd.com/read/29291383/genetic-profiles-of-squamous-cell-carcinomas-associated-with-recessive-dystrophic-epidermolysis-bullosa-unveil-notch-and-tp53-mutations-and-an-increased-myc-expression
#8
L Sans-DeSanNicolas, G Caratú, O Vidal-Cortés, S Sanchez-Redondo, B Ferrer, F Mancuso, E González-Sanchez, M Pérez-Alea, K McGrail, J Hernandez-Losa, D Bodet, A Vivancos, V Garcia-Patos, J A Recio
No abstract text is available yet for this article.
December 29, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29245731/a-new-annual-fish-of-the-genus-i-austrolebias-i-cyprinodontiformes-rivulidae-from-rio-camaqu%C3%A3-basin-laguna-dos-patos-system-brazilian-pampa
#9
Matheus Vieira Volcan, Ândrio Cardozo Gonçalves, Luis Esteban Krause Lanés
A new species of Austrolebias is described from the middle course of the Rio Camaquã, Laguna dos Patos system, Rio Grande do Sul, Brazil. The new species belongs to the Austrolebias alexandri species group, which is distinguished from the remaining congeners by the presence of a dark gray pectoral fin with bright blue iridescence in males. The new species is distinguished from all remaining species of the A. alexandri species group by the following combination of characters: presence of well-defined bright blue bars on the flank in males, shorter caudal fin length in males and females, contact organs in the first three rays of the pectoral fin in males, one to two post-optic neuromasts (rarely three), basihyal width of 50% of the length, and basihyal cartilage about 50-60% of the basihyal length...
October 24, 2017: Zootaxa
https://www.readbyqxmd.com/read/29241207/disease-remission-in-children-and-adolescents-with-intermediate-uveitis-a-survival-analysis
#10
Lara Borrego-Sanz, Lydia Abásolo, Consuelo López-Abad, Benjamín Fernández-Gutiérrez, Julián García-Feijoo, David Diaz-Valle, Esperanza Pato, Luis Rodriguez-Rodriguez
PURPOSE: To report the incidence rate (IR) of remission in pediatric noninfectious intermediate uveitis (IU). METHODS: Longitudinal retrospective cohort study, including 19 patients (32 eyes) between 1985 and 2014, followed-up until loss or January 2016. Remission was defined following the Standardization of Uveitis Nomenclature workshop criteria, prolonged remission as a remission spanning 12 months and until the end of follow-up, and relapse as recurrence of inflammatory activity in an eye in remission...
December 14, 2017: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/29241066/agronomic-efficiency-of-phosphate-fertilizers-produced-by-the-re-use-of-a-metallurgical-acid-residue
#11
Matheus Sampaio Carneiro Barreto, Edson Marcio Mattiello, Wedisson Oliveira Santos, Leônidas Carrijo Azevedo Melo, Leonardus Vergütz, Roberto Ferreira Novais
The production of fertilizers with industrial wastes reduces the environmental impacts of waste disposal and improves environmental sustainability by generating added-value products. Our objective with this study was to evaluate the agronomic performance and potential soil/plant contamination with heavy metals of alternative phosphate (P) fertilizers, obtained from the acidulation of phosphate rocks (PR) by a metallurgical acidic waste. Seven P fertilizers were evaluated: three PR (Araxá, Patos, and Bayóvar), their respective acidulated products (PAPR), and triple superphosphate fertilizer (TSP)...
December 11, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/29184211/whole-genome-sequencing-in-psychiatric-disorders-the-wgspd-consortium
#12
Stephan J Sanders, Benjamin M Neale, Hailiang Huang, Donna M Werling, Joon-Yong An, Shan Dong, Goncalo Abecasis, P Alexander Arguello, John Blangero, Michael Boehnke, Mark J Daly, Kevin Eggan, Daniel H Geschwind, David C Glahn, David B Goldstein, Raquel E Gur, Robert E Handsaker, Steven A McCarroll, Roel A Ophoff, Aarno Palotie, Carlos N Pato, Chiara Sabatti, Matthew W State, A Jeremy Willsey, Steven E Hyman, Anjene M Addington, Thomas Lehner, Nelson B Freimer
No abstract text is available yet for this article.
December 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/29157336/dissociated-components-of-executive-control-in-acute-hypobaric-hypoxia
#13
Endre Takács, István Czigler, Lívia Gabriella Pató, László Balázs
INTRODUCTION: The neurocognitive effects of acute hypobaric hypoxia are still largely unknown. This study was designed to test the hypothesis that executive control, an important component of cognition, is especially vulnerable to hypoxia. METHODS: Subjects participated in a simulated hypobaric chamber flight to 5500 m. Four auditory tasks were presented before, during, and after hypoxia: 1) Voice, and 2) Name variant of the Stroop task (both measuring conflict resolution); 3) go/no-go task (GNG; measuring inhibition); and 4) two-choice reaction time task (CRT; which is a noninhibitory control task)...
December 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/29149307/tumour-tif1-mutations-and-loss-of-heterozygosity-related-to-cancer-associated-myositis
#14
Iago Pinal-Fernandez, Berta Ferrer-Fabregas, Ernesto Trallero-Araguas, Eva Balada, Maria Angeles Martínez, Jose César Milisenda, Gloria Aparicio-Español, Moises Labrador-Horrillo, Vicente Garcia-Patos, Josep M Grau-Junyent, Albert Selva-O'Callaghan
Objectives: To analyse the influence of genetic alterations and differential expression of transcription intermediary factor 1 ( TIF1 ) genes in the pathophysiology of cancer-associated myositis (CAM). Methods: Paired blood and tumour DNA samples from patients with anti-TIF1γ-positive CAM and from controls were analysed by whole-exome sequencing for the presence of somatic mutations and loss of heterozygosity (LOH) in their TIF1 genes. The genesis and maintenance of the autoimmune process were investigated immunohistochemically by studying TIF1γ expression in the different tissues involved in CAM (skin, muscle and tumour) based on the immunohistochemical H-score...
November 14, 2017: Rheumatology
https://www.readbyqxmd.com/read/29101697/nickel-vanadium-and-lead-as-indicators-of-sediment-contamination-of-marina-refinery-and-shipyard-areas
#15
Thayane Lúcia Pereira, Mônica Wallner-Kersanach, Luiza Dy Fonseca Costa, Daniel Pereira Costa, Paulo Roberto Martins Baisch
Metallic elements found in the aquatic environment may originate in areas where petroleum is refined and vessels are maintained and repaired. This study aims to assess contamination caused by nickel (Ni), lead (Pb), and vanadium (V) in sediment of the Lagoa dos Patos estuary (RS, Brazil) and to evaluate them as indicators of areas under the influence of petroleum products and antifouling paints. Surface sediments were collected in summer and in winter in areas of marinas, shipyards, refinery, and a control station...
November 3, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29042551/integrating-evolutionary-and-regulatory-information-with-a-multispecies-approach-implicates-genes-and-pathways-in-obsessive-compulsive-disorder
#16
Hyun Ji Noh, Ruqi Tang, Jason Flannick, Colm O'Dushlaine, Ross Swofford, Daniel Howrigan, Diane P Genereux, Jeremy Johnson, Gerard van Grootheest, Edna Grünblatt, Erik Andersson, Diana R Djurfeldt, Paresh D Patel, Michele Koltookian, Christina M Hultman, Michele T Pato, Carlos N Pato, Steven A Rasmussen, Michael A Jenike, Gregory L Hanna, S Evelyn Stewart, James A Knowles, Stephan Ruhrmann, Hans-Jörgen Grabe, Michael Wagner, Christian Rück, Carol A Mathews, Susanne Walitza, Daniëlle C Cath, Guoping Feng, Elinor K Karlsson, Kerstin Lindblad-Toh
Obsessive-compulsive disorder is a severe psychiatric disorder linked to abnormalities in glutamate signaling and the cortico-striatal circuit. We sequenced coding and regulatory elements for 608 genes potentially involved in obsessive-compulsive disorder in human, dog, and mouse. Using a new method that prioritizes likely functional variants, we compared 592 cases to 560 controls and found four strongly associated genes, validated in a larger cohort. NRXN1 and HTR2A are enriched for coding variants altering postsynaptic protein-binding domains...
October 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/28973778/estimates-of-genetics-and-phenotypics-parameters-for-the-yield-and-quality-of-soybean-seeds
#17
E V Zambiazzi, A T Bruzi, S R Guilherme, D R Pereira, J G Lima, A M Zuffo, F O Ribeiro, A E S Mendes, S H M Godinho, M L M Carvalho
Estimating genotype x environment (GxE) parameters for quality and yield in soybean seed grown in different environments in Minas Gerais State was the goal of this study, as well as to evaluate interaction effects of GxE for soybean seeds yield and quality. Seeds were produced in three locations in Minas Gerais State (Lavras, Inconfidentes, and Patos de Minas) in 2013/14 and 2014/15 seasons. Field experiments were conducted in randomized blocks in a factorial 17 x 6 (GxE), and three replications. Seed yield and quality were evaluated for germination in substrates paper and sand, seedling emergence, speed emergency index, mechanical damage by sodium hypochlorite, electrical conductivity, speed aging, vigor and viability of seeds by tetrazolium test in laboratory using completely randomized design...
September 27, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28973727/diallel-analysis-for-technological-traits-in-upland-cotton
#18
D R Queiroz, F J C Farias, J J V Cavalcanti, L P Carvalho, D G Neder, L S S Souza, F C Farias, P E Teodoro
Final cotton quality is of great importance, and it depends on intrinsic and extrinsic fiber characteristics. The objective of this study was to estimate general (GCA) and specific (SCA) combining abilities for technological fiber traits among six upland cotton genotypes and their fifteen hybrid combinations, as well as to determine the effective genetic effects in controlling the traits evaluated. In 2015, six cotton genotypes: FM 993, CNPA 04-2080, PSC 355, TAM B 139-17, IAC 26, and TAMCOT-CAMD-E and fifteen hybrid combinations were evaluated at the Experimental Station of Embrapa Algodão, located in Patos, PB, Brazil...
September 21, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28950447/proof-of-vivo-pato-oshanin-s-conjecture-on-the-fluctuation-of-von-neumann-entropy
#19
Lu Wei
It was recently conjectured by Vivo, Pato, and Oshanin [Phys. Rev. E 93, 052106 (2016)2470-004510.1103/PhysRevE.93.052106] that for a quantum system of Hilbert dimension mn in a pure state, the variance of the von Neumann entropy of a subsystem of dimension m≤n is given by-ψ_{1}(mn+1)+m+n/mn+1ψ_{1}(n)-(m+1)(m+2n+1)/4n^{2}(mn+1),where ψ_{1}(·) is the trigamma function. We give a proof of this formula.
August 2017: Physical Review. E
https://www.readbyqxmd.com/read/28823029/experience-of-lung-transplantation-in-patients-with-lymphangioleiomyomatosis-at-a-brazilian-reference-centre
#20
Bruno Guedes Baldi, Marcos Naoyuki Samano, Silvia Vidal Campos, Martina Rodrigues de Oliveira, José Eduardo Afonso Junior, Rafael Medeiros Carraro, Ricardo Henrique Oliveira Braga Teixeira, Isabela Pasqualini Minguini, Roni Burlina, Eduardo Zinoni Silva Pato, Carlos Roberto Ribeiro Carvalho, André Nathan Costa
INTRODUCTION: Lung transplantation (LT) is the standard of care for patients with advanced lung diseases, including lymphangioleiomyomatosis (LAM). LAM accounts for only 1% of all LTs performed in the international registry. As a result, the global experience, including the use of mechanistic target of rapamycin (mTOR) inhibitors before and after LT in LAM, is still limited. METHODS: We conducted a retrospective review of all LAM patients who underwent LT at our centre between 2003 and 2016...
December 2017: Lung
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