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https://www.readbyqxmd.com/read/27894280/is-there-any-association-between-sarcoidosis-and-infectious-agents-a-systematic-review-and-meta-analysis
#1
Tiago Esteves, Gloria Aparicio, Vicente Garcia-Patos
BACKGROUND: During the last few years, investigators have debated the role that infectious agents may have in sarcoidosis pathogenesis. With the emergence of new molecular biology techniques, several studies have been conducted; therefore, we performed a meta-analysis in order to better explain this possible association. METHODS: This review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement from the Cochrane collaboration guidelines...
November 28, 2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27887661/biochemical-and-proteomic-analyses-of-the-physiological-response-induced-by-individual-housing-in-gilts-provide-new-potential-stress-markers
#2
Anna Marco-Ramell, Laura Arroyo, Raquel Peña, Raquel Pato, Yolanda Saco, Lorenzo Fraile, Emøke Bendixen, Anna Bassols
BACKGROUND: The objective assessment of animal stress and welfare requires proper laboratory biomarkers. In this work, we have analyzed the changes in serum composition in gilts after switching their housing, from pen to individual stalls, which is generally accepted to cause animal discomfort. RESULTS: Blood and saliva samples were collected a day before and up to four days after changing the housing system. Biochemical analyses showed adaptive changes in lipid and protein metabolism after the housing switch, whereas cortisol and muscular markers showed a large variability between animals...
November 25, 2016: BMC Veterinary Research
https://www.readbyqxmd.com/read/27842607/the-flora-phenotype-ontology-flopo-tool-for-integrating-morphological-traits-and-phenotypes-of-vascular-plants
#3
Robert Hoehndorf, Mona Alshahrani, Georgios V Gkoutos, George Gosline, Quentin Groom, Thomas Hamann, Jens Kattge, Sylvia Mota de Oliveira, Marco Schmidt, Soraya Sierra, Erik Smets, Rutger A Vos, Claus Weiland
BACKGROUND: The systematic analysis of a large number of comparable plant trait data can support investigations into phylogenetics and ecological adaptation, with broad applications in evolutionary biology, agriculture, conservation, and the functioning of ecosystems. Floras, i.e., books collecting the information on all known plant species found within a region, are a potentially rich source of such plant trait data. Floras describe plant traits with a focus on morphology and other traits relevant for species identification in addition to other characteristics of plant species, such as ecological affinities, distribution, economic value, health applications, traditional uses, and so on...
November 14, 2016: Journal of Biomedical Semantics
https://www.readbyqxmd.com/read/27821351/cytochrome-p450-1a-mrna-in-the-guppy-phalloceros-caudimaculatus-and-response-to-beta-naphthoflavone-and-environmental-samples
#4
Roger Stacke Ferreira, Cíntia da Cruz Chivittz, Guilherme Senna Dos Santos, Juliano Zanette
The cytochrome P450 1A (CYP1A) mRNA is induced by environmental contaminants such as PAHs, PCBs and dioxins. The present study cloned the CYP1A transcript from the guppy Phalloceros caudimaculatus, which represents a potential fish for toxicological studies in South America. The newly identified CYP1A encodes a protein with 521 amino acids that shared 96-70% identity with other fishes. The characterization of organ- and time-dependent induction of CYP1A using RT-qPCR was evaluated after waterborne exposure to beta-naphthoflavone (BNF; 1μM)...
December 2016: Aquatic Toxicology
https://www.readbyqxmd.com/read/27815703/development-of-an-activity-disease-score-in-patients-with-uveitis-uvedai
#5
Esperanza Pato, Mª Auxiliadora Martin-Martinez, Adela Castelló, Rosalía Méndez-Fernandez, Santiago Muñoz-Fernández, Miguel Cordero-Coma, Lucia Martinez-Costa, Elia Valls, Miguel Reyes, Félix Francisco, Mar Esteban, Alex Fonollosa, Fernando Sanchez-Alonso, Cruz Fernández-Espartero, Teresa Diaz-Valle, José Miguel Carrasco, Emma Beltran-Catalán, Marisa Hernández-Garfella, María Victoria Hernández, Laura Pelegrin, Ricardo Blanco, David Diaz-Valle
To develop a disease activity index for patients with uveitis (UVEDAI) encompassing the relevant domains of disease activity considered important among experts in this field. The steps for designing UVEDAI were: (a) Defining the construct and establishing the domains through a formal judgment of experts, (b) A two-round Delphi study with a panel of 15 experts to determine the relevant items, (c) Selection of items: A logistic regression model was developed that set ocular inflammatory activity as the dependent variable...
November 4, 2016: Rheumatology International
https://www.readbyqxmd.com/read/27751521/utility-of-ultrasound-in-a-rapidly-growing-cutaneous-nodule-in-an-infant
#6
Maria Ubals, Anna Castany, Patricia Bassas, Jordi Mollet, Gloria Aparicio, Vicente García-Patos
No abstract text is available yet for this article.
October 14, 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27749239/treatment-in-rheumatoid-arthritis-and-mortality-risk-in-clinical-practice-the-role-of-biologic-agents
#7
Luis Rodriguez-Rodriguez, Leticia Leon, Jose Ivorra-Cortes, Alejandro Gómez, Jose Ramon Lamas, Esperanza Pato, Juan Angel Jover, Lydia Abásolo
OBJECTIVES: To assess the mortality rate (MR) and the mortality risk of a rheumatoid arthritis (RA) inception cohort, with and without biologic agents (BAs). Other factors associated to mortality were also investigated. METHODS: Retrospective longitudinal study of RA patients, attending the rheumatology outpatient clinic of a tertiary Hospital (Madrid), collected over 5 years (2000-2004), and followed from the diagnosis of RA up to the patients' death, lost to follow-up or September 2013...
October 7, 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27745738/determination-of-hydrocarbons-transported-by-urban-runoff-in-sediments-of-s%C3%A3-o-gon%C3%A3-alo-channel-pelotas-rs-brazil
#8
Pedro J Sanches Filho, Emerson M Böhm, Giani M B Böhm, Gissele O Montenegro, Lucas A Silveira, Glauco R Betemps
A high concentration of hydrocarbons in the environment is indicative of pollution. To evaluate the effect of hydrocarbons transported by urban runoff, the present study analyzed total petroleum hydrocarbons (TPHs), aliphatic hydrocarbons (AHs), unresolved complex mixture (UCM), and n-alkanes of the sediments of the canal that cross the urban area of Pelotas, Rio Grande do Sul, Brazil. The carbon preference index (CPI), terrigenous/aquatic ratio (TAR), and pristane/phytane ratio were determined. The TPH content ranged from 177,043...
October 11, 2016: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/27726475/efficacy-of-anti-il6-receptor-tocilizumab-in-refractory-cystoid-macular-edema-of-birdshot-retinochoroidopathy-report-of-two-cases-and-literature-review
#9
Vanesa Calvo-Río, Ricardo Blanco, Montserrat Santos-Gómez, David Díaz-Valle, Esperanza Pato, Javier Loricera, María C González-Vela, Rosalía Demetrio-Pablo, José L Hernández, Miguel A González-Gay
PURPOSE: To evaluate tocilizumab (TCZ) efficacy in severe and refractory birdshot chorioretinopathy (BSCR). METHODS: Assessment of BSCR patients refractory to conventional immunosuppressive and anti-TNF-α drugs who underwent TCZ therapy. RESULTS: Two HLA-A29 positive patients (man/37 years and woman/38 years; four affected eyes) with BSCR were studied. They had a chronic bilateral posterior uveitis. Patient 1 had been treated with intraocular and oral corticosteroids, cyclosporine A, and infliximab whereas Patient 2 received intravenous methylprednisolone pulses, cyclosporine A, azathioprine, and adalimumab...
October 11, 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/27726334/the-inosine-monophosphate-dehydrogenase-guab2-is-a-vulnerable-new-bactericidal-drug-target-for-tuberculosis
#10
Vinayak Singh, Stefano Donini, Angela Pacitto, Claudia Sala, Ruben C Hartkoorn, Neeraj Dhar, Gyorgy Keri, David B Ascher, Guillaume Mondésert, Anthony Vocat, Andréanne Lupien, Raphael Sommer, Hélène Vermet, Sophie Lagrange, Joe Buechler, Digby F Warner, John D McKinney, Janos Pato, Stewart T Cole, Tom L Blundell, Menico Rizzi, Valerie Mizrahi
VCC234718, a molecule with growth inhibitory activity against Mycobacterium tuberculosis (Mtb), was identified by phenotypic screening of a 15344-compound library. Sequencing of a VCC234718-resistant mutant identified a Y487C substitution in the inosine monophosphate dehydrogenase, GuaB2, which was subsequently validated to be the primary molecular target of VCC234718 in Mtb. VCC234718 inhibits Mtb GuaB2 with a Ki of 100 nM and is uncompetitive with respect to IMP and NAD(+). This compound binds at the NAD(+) site, after IMP has bound, and makes direct interactions with IMP; therefore, the inhibitor is by definition uncompetitive...
September 8, 2016: ACS Infectious Diseases
https://www.readbyqxmd.com/read/27677649/identification-of-aminopyrimidine-sulfonamides-as-potent-modulators-of-wag31-mediated-cell-elongation-in-mycobacteria
#11
Vinayak Singh, Neeraj Dhar, János Pató, Gaëlle S Kolly, Jana Korduláková, Martin Forbak, Joanna C Evans, Rita Székely, Jan Rybniker, Zuzana Palčeková, Júlia Zemanová, Isabella Santi, François Signorino-Gelo, Liliana Rodrigues, Anthony Vocat, Adrian S Covarrubias, Monica G Rengifo, Kai Johnsson, Sherry Mowbray, Joseph Buechler, Vincent Delorme, Priscille Brodin, Graham W Knott, José A Aínsa, Digby F Warner, György Kéri, Katarína Mikušová, John D McKinney, Stewart T Cole, Valerie Mizrahi, Ruben C Hartkoorn
There is an urgent need to discover new anti-tubercular agents with novel mechanisms of action in order to tackle the scourge of drug-resistant tuberculosis. Here, we report the identification of such a molecule - an AminoPYrimidine-Sulfonamide (APYS1) that has potent, bactericidal activity against M. tuberculosis. Mutations in APYS1-resistant M. tuberculosis mapped exclusively to wag31, a gene that encodes a scaffolding protein thought to orchestrate cell elongation. Recombineering confirmed that a Gln201Arg mutation in Wag31 was sufficient to cause resistance to APYS1, however, neither overexpression nor conditional depletion of wag31 impacted M...
September 28, 2016: Molecular Microbiology
https://www.readbyqxmd.com/read/27658431/-fingolimod-effectiveness-and-safety-in-routine-clinical-practice-an-observational-retrospective-multi-centre-study-in-galicia
#12
A Pato-Pato, L Midaglia, E Costa-Arpin, A Rodriguez-Regal, A Puy-Nunez, M Rodriguez-Rodriguez, A Lopez-Real, M A Llaneza-Gonzalez, D A Garcia-Estevez, M J Moreno-Carretero, D Escriche-Jaime, M L Aguado-Valcarcel, D Munoz, J M Prieto, J R Lorenzo-Gonzalez, M C Amigo-Jorrin
INTRODUCTION: The effectiveness and safety of fingolimod in patients with relapsing-remitting multiple sclerosis (RRMS) have been proven in clinical trials. Yet, due to their limitations, it is important to know how it behaves under everyday clinical practice conditions. Hence, the aim of this study is to evaluate the effectiveness and safety of fingolimod after 12 months' usage in clinical practice in Galicia. PATIENTS AND METHODS: We conducted a retrospective, multi-centre study (n = 8) of patients with RRMS who were treated with one or more doses of fingolimod, 0...
September 5, 2016: Revista de Neurologia
https://www.readbyqxmd.com/read/27621022/preoperative-urinary-tract-infection-increases-postoperative-morbidity
#13
Courtney J Pokrzywa, Christina M Papageorge, Gregory D Kennedy
BACKGROUND: Preoperative urinary tract infection (UTI) may be associated with surgical site infections secondary to hematogenous spread of bacteria. The association between preoperative UTI and postoperative complications has not been evaluated in general surgery populations. MATERIALS AND METHODS: Patients undergoing elective general surgery procedures from 2011 to 2013 were selected from the American College of Surgeons National Surgical Quality Improvement Program database...
September 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27575116/pseudo-hermitian-ensemble-of-random-gaussian-matrices
#14
G Marinello, M P Pato
It is shown how pseudo-Hermiticity, a necessary condition satisfied by operators of PT symmetric systems can be introduced in the three Gaussian classes of random matrix theory. The model describes transitions from real eigenvalues to a situation in which, apart from a residual number, the eigenvalues are complex conjugate.
July 2016: Physical Review. E
https://www.readbyqxmd.com/read/27548312/a-reference-panel-of-64-976-haplotypes-for-genotype-imputation
#15
Shane McCarthy, Sayantan Das, Warren Kretzschmar, Olivier Delaneau, Andrew R Wood, Alexander Teumer, Hyun Min Kang, Christian Fuchsberger, Petr Danecek, Kevin Sharp, Yang Luo, Carlo Sidore, Alan Kwong, Nicholas Timpson, Seppo Koskinen, Scott Vrieze, Laura J Scott, He Zhang, Anubha Mahajan, Jan Veldink, Ulrike Peters, Carlos Pato, Cornelia M van Duijn, Christopher E Gillies, Ilaria Gandin, Massimo Mezzavilla, Arthur Gilly, Massimiliano Cocca, Michela Traglia, Andrea Angius, Jeffrey C Barrett, Dorrett Boomsma, Kari Branham, Gerome Breen, Chad M Brummett, Fabio Busonero, Harry Campbell, Andrew Chan, Sai Chen, Emily Chew, Francis S Collins, Laura J Corbin, George Davey Smith, George Dedoussis, Marcus Dorr, Aliki-Eleni Farmaki, Luigi Ferrucci, Lukas Forer, Ross M Fraser, Stacey Gabriel, Shawn Levy, Leif Groop, Tabitha Harrison, Andrew Hattersley, Oddgeir L Holmen, Kristian Hveem, Matthias Kretzler, James C Lee, Matt McGue, Thomas Meitinger, David Melzer, Josine L Min, Karen L Mohlke, John B Vincent, Matthias Nauck, Deborah Nickerson, Aarno Palotie, Michele Pato, Nicola Pirastu, Melvin McInnis, J Brent Richards, Cinzia Sala, Veikko Salomaa, David Schlessinger, Sebastian Schoenherr, P Eline Slagboom, Kerrin Small, Timothy Spector, Dwight Stambolian, Marcus Tuke, Jaakko Tuomilehto, Leonard H Van den Berg, Wouter Van Rheenen, Uwe Volker, Cisca Wijmenga, Daniela Toniolo, Eleftheria Zeggini, Paolo Gasparini, Matthew G Sampson, James F Wilson, Timothy Frayling, Paul I W de Bakker, Morris A Swertz, Steven McCarroll, Charles Kooperberg, Annelot Dekker, David Altshuler, Cristen Willer, William Iacono, Samuli Ripatti, Nicole Soranzo, Klaudia Walter, Anand Swaroop, Francesco Cucca, Carl A Anderson, Richard M Myers, Michael Boehnke, Mark I McCarthy, Richard Durbin
We describe a reference panel of 64,976 human haplotypes at 39,235,157 SNPs constructed using whole-genome sequence data from 20 studies of predominantly European ancestry. Using this resource leads to accurate genotype imputation at minor allele frequencies as low as 0.1% and a large increase in the number of SNPs tested in association studies, and it can help to discover and refine causal loci. We describe remote server resources that allow researchers to carry out imputation and phasing consistently and efficiently...
October 2016: Nature Genetics
https://www.readbyqxmd.com/read/27510735/spiny-hyperkeratosis-trichodysplasia-spinulosa-like-eruption-a-cutaneous-adverse-effect-of-hedgehog-pathway-inhibitors-involving-expression-of-p16
#16
I López-Lerma, B Ferrer, I Zarzoso, J Hernández-Losa, V García-Patos
The Hedgehog (Hh) pathway has a critical role in embryogenesis.(1) Hh signaling remains active in a more limited extent throughout the life with a key role in the somatic stem cell populations through modulation of self-renewal activity. Moreover, Hh signaling is aberrantly activated in a number of malignancies and the most common way to target this pathway is modulate Smoothened (SMO).(1,2) A 79-year-old Caucasian man presented with a 3-month history of erythematous papules and hyperkeratotic lesions over the face...
August 11, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27509577/a-rapidly-enlarging-nodule-on-the-scalp-in-an-infant
#17
Ingrid Lopez-Lerma, Alexandra Navarro, Vicente García-Patos
No abstract text is available yet for this article.
August 10, 2016: International Journal of Dermatology
https://www.readbyqxmd.com/read/27470773/inventory-of-the-freshwater-fishes-from-a-densely-collected-area-in-south-america-a-case-study-of-the-current-knowledge-of-neotropical-fish-diversity
#18
Vinicius A Bertaco, Juliano Ferrer, Fernando R Carvalho, Luiz R Malabarba
We herein analyse the history of the description of the freshwater fish fauna from three drainages in one of the most densely collected areas of Brazil, and possibly of South America, the Rio Grande do Sul State, southern Brazil. An updated inventory of the freshwater fish species from rio Uruguay (partial) in Brazil, Laguna dos Patos (complete) and rio Tramandaí basins (complete) is presented. We found the number of new species described in these drainages increased nearly 56% since 1981, reaching a total of 422 species, but even now 10% of this number still corresponds to undescribed species...
2016: Zootaxa
https://www.readbyqxmd.com/read/27300829/random-pure-states-quantifying-bipartite-entanglement-beyond-the-linear-statistics
#19
Pierpaolo Vivo, Mauricio P Pato, Gleb Oshanin
We analyze the properties of entangled random pure states of a quantum system partitioned into two smaller subsystems of dimensions N and M. Framing the problem in terms of random matrices with a fixed-trace constraint, we establish, for arbitrary N≤M, a general relation between the n-point densities and the cross moments of the eigenvalues of the reduced density matrix, i.e., the so-called Schmidt eigenvalues, and the analogous functionals of the eigenvalues of the Wishart-Laguerre ensemble of the random matrix theory...
May 2016: Physical Review. E
https://www.readbyqxmd.com/read/27296486/immunosuppressive-drug-discontinuation-in-noninfectious-uveitis-from-real-life-clinical-practice-a-survival-analysis
#20
Lydia Abásolo, Zulema Rosales, David Díaz-Valle, Alejandro Gómez-Gómez, Rayma C Peña-Blanco, Ángela Prieto-García, José Manuel Benítez-Del-Castillo, Esperanza Pato, Julián García-Feijoo, Benjamín Fernández-Gutiérrez, Luis Rodriguez-Rodriguez
PURPOSE: To assess in uveitis patients the rate of immunosuppressive drug (ISD) discontinuation in real-life clinical practice, comparing this rate among ISDs. DESIGN: Longitudinal retrospective cohort study. METHODS: We included uveitis patients attending a tertiary eye referral center from Madrid (Spain) between 1989 and 2015, prescribed any ISDs (cyclosporine, methotrexate, azathioprine, anti-TNF drugs, or others). Our main outcome was discontinuation of all ISDs owing to clinical efficacy, inefficacy, adverse drug reaction (ADR), and other medical causes...
September 2016: American Journal of Ophthalmology
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