keyword
MENU ▼
Read by QxMD icon Read
search

INTERACT

keyword
https://www.readbyqxmd.com/read/28749609/ricochet-pollination-in-senna-fabaceae-petals-deflect-pollen-jets-and-promote-division-of-labour-among-flower-organs
#1
Thiago Amorim, Brigitte Marazzi, Arlete A Soares, Eliana R Forni-Martins, Celli R Muniz, Christian Westerkamp
Naturalists Fritz and Hermann Müller hypothesised that heteranthery often leads to a division of labour into 'feeding' and 'pollinating' stamens; the latter often being as long as the pistil so as to promote successful pollination on the bees' back. In many buzz-pollinated species of Senna, however, the so-called pollinating stamens are short and do not level with the stigma, raising the question of how pollen is shed on the bees' back. Here we explore a mechanism called "ricochet pollination". We test whether division of labour is achieved through the interaction between short lower stamens and strongly concave "deflector petals"...
July 27, 2017: Plant Biology
https://www.readbyqxmd.com/read/28749581/prediction-of-transporter-mediated-drug-drug-interactions-for-baricitinib
#2
Maria M Posada, Ellen A Cannady, Christopher D Payne, Xin Zhang, James A Bacon, Y Anne Pak, J William Higgins, Nazila Shahri, Stephen D Hall, Kathleen M Hillgren
Baricitinib, an oral selective Janus kinase 1 and 2 inhibitor, undergoes active renal tubular secretion. Baricitinib was not predicted to inhibit hepatic and renal uptake and efflux drug transporters, based on the ratio of the unbound maximum eliminating-organ inlet concentration and the in vitro half-maximal inhibitory concentrations (IC50 ). In vitro, baricitinib was a substrate for organic anion transporter (OAT)3, multidrug and toxin extrusion protein (MATE)2-K, P-glycoprotein (P-gp), and breast cancer resistance protein (BCRP)...
July 27, 2017: Clinical and Translational Science
https://www.readbyqxmd.com/read/28749575/comparing-pairwise-additive-and-many-body-generalized-born-models-for-acid-base-calculations-and-protein-design
#3
Francesco Villa, David Mignon, Savvas Polydorides, Thomas Simonson
Generalized Born (GB) solvent models are common in acid/base calculations and protein design. With GB, the interaction between a pair of solute atoms depends on the shape of the protein/solvent boundary and, therefore, the positions of all solute atoms, so that GB is a many-body potential. For compute-intensive applications, the model is often simplified further, by introducing a mean, native-like protein/solvent boundary, which removes the many-body property. We investigate a method for both acid/base calculations and protein design that uses Monte Carlo simulations in which side chains can explore rotamers, bind/release protons, or mutate...
July 27, 2017: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/28749536/the-lack-of-a-relationship-between-physician-payments-from-drug-manufacturers-and-medicare-claims-for-abiraterone-and-enzalutamide
#4
Jathin Bandari, Omar M Ayyash, Robert M Turner, Bruce L Jacobs, Benjamin J Davies
BACKGROUND: Interactions between industry and prescribers have raised concerns regarding conflicts of interest. To the best of the authors' knowledge, quantitative data measuring these interactions have been limited until recently. In the current study, the authors sought to determine whether an association exists between industry payments and prescriber behavior with regard to abiraterone and enzalutamide. METHODS: Two Centers for Medicare and Medicaid Services databases were combined to analyze oncologists and urologists who received industry payments and/or prescribed abiraterone and enzalutamide...
July 27, 2017: Cancer
https://www.readbyqxmd.com/read/28749519/atomic-scale-computational-design-of-hydrophobic-re-surface-doped-al2o3-and-tio2
#5
Kamil Czelej, Marcin Roland Zemła, Piotr Spiewak, Tomasz Wejrzanowski, Krzysztof Jan Kurzydłowski
Intrinsically hydrophobic rare-earth oxides (REOs) have emerged as a robust class of ceramics for a variety of applications. Recently, the hydrophobicity of REOs has been observed experimentally and subsequently scrutinized using electronic structure density functional theory (DFT) calculations. In this work, we applied the DFT method to analyze the possibility of tuning the wettability of commonly used hydrophilic Al2O3 and TiO2 by surface doping with Ce. The calculations indicate that Ce can preferentially segregate to the surface of Al2O3 and TiO2 and form a Ce-rich oxide layer, which is stable under a wide range of oxygen chemical potentials...
July 27, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28749512/excited-state-intermolecular-proton-transfer-dependent-on-the-substitution-pattern-of-anthracene-diurea-compounds-involved-in-fluorescent-on-1-off-on-2-response-by-the-addition-of-acetate-ions
#6
Hisato Matsumoto, Yoshinobu Nishimura, Tatsuo Arai
We report anthracene-diurea compounds which behave as anion sensors based on the fluorescence emission regulated by the substitution position on the anthracene ring. Anthracene-diurea compounds exhibit different excited-state intermolecular proton transfer (ESIPT) reactions depending on the pattern of the substituents. Three new anthracene-diurea compounds that have two phenylurea groups substituted at different positions on anthracene were synthesized. These compounds formed complexes with acetate ions through intermolecular hydrogen bonding between N-H and C[double bond, length as m-dash]O moieties in the ground state...
July 27, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28749508/linking-hygroscopicity-and-the-surface-microstructure-of-model-inorganic-salts-simple-and-complex-carbohydrates-and-authentic-sea-spray-aerosol-particles
#7
Armando D Estillore, Holly S Morris, Victor W Or, Hansol D Lee, Michael R Alves, Meagan A Marciano, Olga Laskina, Zhen Qin, Alexei V Tivanski, Vicki H Grassian
Individual airborne sea spray aerosol (SSA) particles show diversity in their morphologies and water uptake properties that are highly dependent on the biological, chemical, and physical processes within the sea subsurface and the sea surface microlayer. In this study, hygroscopicity data for model systems of organic compounds of marine origin mixed with NaCl are compared to data for authentic SSA samples collected in an ocean-atmosphere facility providing insights into the SSA particle growth, phase transitions and interactions with water vapor in the atmosphere...
July 27, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28749507/interaction-of-feo-with-water-anion-photoelectron-spectroscopy-and-theoretical-calculations
#8
Li-Juan Zhao, Xi-Ling Xu, Hong-Guang Xu, Gang Feng, Wei-Jun Zheng
The interactions of FeO(-) with water molecules were studied by using photoelectron spectroscopy and density functional theoretical calculations. It is found that a dihydroxyl species, Fe(OH)2(-/0), can be formed when FeO(-/0) interacts with the first water molecule. The complexes formed via the interactions between FeO(-/0) and n water molecules can be viewed as Fe(OH)2(H2O)n-1(-/0), in which (n - 1)H2O molecules interact with a Fe(OH)2 core. For Fe(OH)2(-/0) and Fe(OH)2(H2O)(-), the Fe(OH)2 unit has two conformers with the two OH groups oriented differently...
July 27, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28749506/the-origin-of-high-electrocatalytic-activity-of-hydrogen-peroxide-reduction-reaction-by-a-g-c3n4-hopg-sensor
#9
C G Gomez, A M Silva, M C Strumia, L B Avalle, M I Rojas
Graphitic carbon nitride (g-C3N4) was synthesized from a low-cost precursor by means of a thermal process. The product was characterized by several spectroscopic techniques and the crystallinity was analyzed by X-ray diffraction. In the manufacture of the sensor, g-C3N4 was chemically exfoliated and a film was placed on the surface of a Highly Oriented Pyrolytic Graphite (HOPG). We compared the electrocatalytic activities of g-C3N4/HOPG and pristine HOPG surfaces as sensors for H2O2 quantification in buffer solution at pH 7...
July 27, 2017: Nanoscale
https://www.readbyqxmd.com/read/28749490/evidence-for-cooperative-na-and-cl-binding-by-strongly-hydrated-l-proline
#10
Olga A Dmitrieva, Marina V Fedotova, Richard Buchner
In nature the amino acid l-proline (Pro) is a ubiquitous and highly effective osmolyte protecting cells against osmotic stress. To understand this effect knowledge of the hydration of Pro and its interactions with dissolved salts is essential. We studied these properties by combining statistical mechanics and broadband dielectric spectroscopy and found that Pro remains strongly hydrated up to high amino-acid concentrations. This is also the case upon NaCl addition to a 0.6 M Pro solution. Here, additionally a Pro·NaCl aggregate is formed with a stability constant of K° ≈ 0...
July 27, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28749488/trends-in-provider-initiated-versus-spontaneous-preterm-deliveries-2004-2013
#11
M L Ada, M R Hacker, T H Golen, M J Haviland, S A Shainker, H H Burris
OBJECTIVE: The objectives of this study were as follows: (i) to estimate the proportion of preterm deliveries at a tertiary perinatal center that were provider-initiated versus spontaneous before and after a 2009 policy to reduce elective early-term deliveries, and (ii)to evaluate whether shifts in type of preterm delivery varied by race/ethnicity. METHOD: We performed a retrospective cohort study of preterm deliveries over a 10-year period, 2004 to 2013, including detailed review of 929 of 5566 preterm deliveries, to designate each delivery as provider-initiated or spontaneous...
July 27, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28749487/autoimmune-conditions-and-comorbid-depression-in-pregnancy-examining-the-risk-of-preterm-birth-and-preeclampsia
#12
G Bandoli, C D Chambers
OBJECTIVE: The objective of this study was to determine whether prenatal depression interacts with autoimmune conditions to further increase the risk of preterm birth or preeclampsia. STUDY DESIGN: Our sample included 3034 pregnant women with rheumatoid arthritis (RA), Crohn's disease (CD) or psoriasis, or controls that were prospectively enrolled into MothertoBaby pregnancy studies. We estimated the independent and joint effects of the three autoimmune conditions and depression on the select outcomes...
July 27, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28749472/retinoic-acid-induced-upregulation-of-mir-219-promotes-the-differentiation-of-embryonic-stem-cells-into-neural-cells
#13
Haibo Wu, Jiamin Zhao, Beibei Fu, Songna Yin, Chao Song, Jingcheng Zhang, Shanting Zhao, Yong Zhang
MicroRNAs (miRNAs) regulate critical cell processes, such as apoptosis, proliferation, and development. However, the role of miRNAs in embryonic stem cell (ESC) neural differentiation induced by retinoic acid (RA) and factors that govern neural directional differentiation remain poorly understood. In this study, we demonstrated that miR-219 is sufficient in promoting mouse ESCs to undergo neural differentiation. We discovered that Foxj3 and Zbtb18, two target genes of miR-219, are not able to determine the process of RA-induced differentiation, however they prevent ESCs from differentiating into neural cells...
July 27, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28749471/pre-synaptic-trkb-in-basolateral-amygdala-neurons-mediates-bdnf-signaling-transmission-in-memory-extinction
#14
Yuan Li, Dongdong Wang, Yang Li, Hongxia Chu, Lining Zhang, Ming Hou, Xingyu Jiang, Zheyu Chen, Bo Su, Tao Sun
Brain-derived neurotrophic factor (BDNF) and its high affinity receptor, TrkB, play an essential role in memory extinction. Our previous work has shown that JIP3 (JNK interacted protein 3) mediates anterograde axonal transport of TrkB through the direct binding of its coiled-coil domain 1 (CC1) with TrkB. Here, we constructed a fluorescent CC1 and enhanced green fluorescent protein (EGFP) fused protein, CC1-EGFP, and found that CC1-EGFP could specifically interrupt TrkB anterograde axonal transport and its localization at the pre-synaptic site...
July 27, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28749465/acid-sphingomyelinase-mediates-human-cd4-t-cell-signaling-potential-roles-in-t-cell-responses-and-diseases
#15
REVIEW
Aiping Bai, Yuan Guo
Acid sphingomyelinase (ASM) is a lipid hydrolase. By generating ceramide, ASM had been reported to have an important role in regulating immune cell functions inclusive of macrophages, NK cells, and CD8(+) T cells, whereas the role of ASM bioactivity in regulation of human CD4(+) T-cell functions remained uncertain. Recent studies have provided novel findings in this field. Upon stimulation of CD3 and/or CD28, ASM-dependent ceramide signaling mediates intracellular downstream signal cascades of CD3 and CD28, and regulates CD4(+) T-cell activation and proliferation...
July 27, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28749443/study-of-the-interactions-of-bovine-serum-albumin-with-the-new-anti-inflammatory-agent-4-1-3-dioxo-1-3-dihydro-2h-isoindol-2-yl-n-4-ethoxy-phenyl-methylidene-benzohydrazide-using-a-multi-spectroscopic-approach-and-molecular-docking
#16
Tanveer A Wani, Ahmed H Bakheit, Abdul-Rahman A Al-Majed, Mashooq A Bhat, Seema Zargar
The lipophilic derivative of thalidomide (4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-N'-[(4-ethoxyphenyl)methylidene]benzohydrazide, 6P) was synthesized to enhance its characteristics and efficacy. Earlier studies have proved the immunomodulatory and anti-inflammatory effects of 6P. In this study the interaction between bovine serum albumin (BSA) and 6P was studied using a multi-spectroscopic approach which included UV spectrophotometry, spectrofluorimetry and three dimensional spectrofluorometric and molecular docking studies...
July 27, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28749431/iot-service-clustering-for-dynamic-service-matchmaking
#17
Shuai Zhao, Le Yu, Bo Cheng, Junliang Chen
As the adoption of service-oriented paradigms in the IoT (Internet of Things) environment, real-world devices will open their capabilities through service interfaces, which enable other functional entities to interact with them. In an IoT application, it is indispensable to find suitable services for satisfying users' requirements or replacing the unavailable services. However, from the perspective of performance, it is inappropriate to find desired services from the service repository online directly. Instead, clustering services offline according to their similarity and matchmaking or discovering service online in limited clusters is necessary...
July 27, 2017: Sensors
https://www.readbyqxmd.com/read/28749422/metamaterials-and-metasurfaces-for-sensor-applications
#18
REVIEW
Yohan Lee, Sun-Je Kim, Hyeonsoo Park, Byoungho Lee
Electromagnetic metamaterials (MMs) and metasurfaces (MSs) are artificial media and surfaces with subwavelength separations of meta-atoms designed for anomalous manipulations of light properties. Owing to large scattering cross-sections of metallic/dielectric meta-atoms, it is possible to not only localize strong electromagnetic fields in deep subwavelength volume but also decompose and analyze incident light signal with ultracompact setup using MMs and MSs. Hence, by probing resonant spectral responses from extremely boosted interactions between analyte layer and optical MMs or MSs, sensing the variation of refractive index has been a popular and practical application in the field of photonics...
July 27, 2017: Sensors
https://www.readbyqxmd.com/read/28749415/association-between-toenail-magnesium-and-type-2-diabetes-in-chinese-adults
#19
Jiguo Zhang, Huijun Wang, Zhihong Wang, Ji Zhang, Bing Zhang
Previous studies have showed an inverse association between magnesium level and type 2 diabetes, but the results are inconsistent, and the evidence relates only to dietary and serum magnesium. Moreover, it is not certain how these findings are applicable to Asian people. This study was designed to examine the association between toenail magnesium and type 2 diabetes in Chinese adults. The sample was 5683 adults aged 18 years or older from the 2009 China Health and Nutrition Survey. We used hemoglobin A1c equal to or greater than 6...
July 27, 2017: Nutrients
https://www.readbyqxmd.com/read/28749407/multi-robot-interfaces-and-operator-situational-awareness-study-of-the-impact-of-immersion-and-prediction
#20
Juan Jesús Roldán, Elena Peña-Tapia, Andrés Martín-Barrio, Miguel A Olivares-Méndez, Jaime Del Cerro, Antonio Barrientos
Multi-robot missions are a challenge for operators in terms of workload and situational awareness. These operators have to receive data from the robots, extract information, understand the situation properly, make decisions, generate the adequate commands, and send them to the robots. The consequences of excessive workload and lack of awareness can vary from inefficiencies to accidents. This work focuses on the study of future operator interfaces of multi-robot systems, taking into account relevant issues such as multimodal interactions, immersive devices, predictive capabilities and adaptive displays...
July 27, 2017: Sensors
keyword
keyword
75606
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"