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https://www.readbyqxmd.com/read/29169169/effects-and-interactions-of-prenatal-ethanol-exposure-a-post-weaning-high-fat-diet-and-gender-on-adult-hypercholesterolemia-occurrence-in-offspring-rats
#1
Yongjian Qi, Hanwen Luo, Shuwei Hu, Yimeng Wu, Jacques Magdalou, Liaobin Chen, Hui Wang
BACKGROUND/AIMS: Prenatal ethanol exposure (PEE) could induce intrauterine programming of hypothalamic-pituitary-adrenal axis-associated neuroendocrine metabolism, resulting in intrauterine growth retardation and susceptibility to adult hypercholesterolemia in offspring. This study aimed to analyse the effects and interactions of PEE, a post-weaning high-fat diet (HFD) and gender on the occurrence of adult hypercholesterolemia in offspring rats. METHODS: Wistar female rats were treated with ethanol (4 g/kg...
November 23, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29169161/digoxin-and-hypermagnesuria
#2
Luca Zanoli, Paolo Lentini, Pasquale Fatuzzo
In a recent issue of Nephron, Abu-Amer et al.[<xref ref-type="bibr" rid="ref1">1</xref>] reported the presence of hypermagnesuria in patients following acute intravenous administration of digoxin and suggested that the Na+/K+-ATPase γ-subunit, which is the pharmacological target of digoxin, can play a role in this process. Hypermagnesuria induced by digoxin may have important clinical consequences, particularly in the presence of inherited and acquired conditions associated with hypermagnesuria and hypomagnesemia...
November 23, 2017: Nephron
https://www.readbyqxmd.com/read/29169157/tnf-%C3%AE-regulates-mast-cell-functions-by-inhibiting-cell-degranulation
#3
Yuwei Gao, Baixue Xu, Peng Zhang, Yanlong He, Xin Liang, Jianwen Liu, Jiyu Li
BACKGROUND/AIMS: The aim of this study was to investigate the involvement of inducible co-stimulatory ligand (ICOSL) expression in stimulation of mast cells (MCs) by TNF-α and the ability of TNF-α stimulation of MCs to influence CD4+ T cell differentiation and function. The mechanisms underlying TNF-α stimulation of MCs were also explored. METHODS: Mast cells and CD4+ T cells were prepared from C57BL/6 mice (aged 6-8 weeks). ICOSL expression by MCs was measured by real-time PCR and flow cytometry, and levels of IL-4, IL-10 and IFN-γ were measured by ELISA...
November 23, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29169144/targeting-the-wnt-beta-catenin-pathway-in-cancer-update-on-effectors-and-inhibitors
#4
REVIEW
Nithya Krishnamurthy, Razelle Kurzrock
The Wnt/beta-catenin pathway is a family of proteins that is implicated in many vital cellular functions like stem cell regeneration and organogenesis. Several intra-cellular signal transduction pathways are induced by Wnt, notably the Wnt/beta-catenin dependent pathway or canonical pathway and the non-canonical or beta-catenin-independent pathway, the latter includes the Wnt/Ca2+ and Planar Cell Polarity pathway (PCP). Wnt activation occurs at the intestinal crypt floor, and is critical to optimal maintenance of stem cells...
November 13, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/29169126/effect-of-copper-on-the-translocation-and-transformation-of-polychlorinated-biphenyls-in-rice
#5
Lili Pan, Jianteng Sun, X Chris Le, Lizhong Zhu
Contamination of organic pollutants in the environment is usually accompanied by heavy metals. However, a little information on the influences of heavy metals on the uptake, translocation and transformation of organic pollutants in plants is available. In this study, ten-day hydroponic exposure was conducted to explore the influence of copper (Cu) on the bioaccumulation and biotransformation of polychlorinated biphenyls (PCBs) in intact young rice (Oryza sativa L.). Low dose of Cu (≤100 μmol/L) increased the accumulation of CB-61 in rice plants, while excess concentrations of Cu (>100 μmol/L) inhibited uptake and translocation of CB-61...
November 13, 2017: Chemosphere
https://www.readbyqxmd.com/read/29169113/a-rapid-and-simple-hplc-ms-ms-method-for-the-simultaneous-quantification-of-valproic-acid-and-its-five-metabolites-in-human-plasma-and-application-to-study-pharmacokinetic-interaction-in-chinese-epilepsy-patients
#6
Dingsheng Wen, Ziyi Chen, Chao Yang, Huanbin Liu, Hongliang Li, Juan Chen, Qiling Dai, Guoping Zhong, Jiaming Qin, Guanzhong Ni, Min Huang, Liemin Zhou, Xueding Wang
Valproic acid(VPA) is a classic drug that used to treat epilepsy in monotherapy or combination with other anticonvulsant drugs such as lamotrigine (LTG). Although it was reported that VPA could increase lamotrigine trough concentration in clinical practice, there was no report about the effect of LTG on the trough concentration of VPA and its main metabolites, such as 4-ene-VPA, 3-OH-VPA, 4-OH-VPA, 3-keto-VPA, 2-PGA which are related to the therapeutic and toxic effects of VPA. In this study, a simple and rapid method for the simultaneous determination of VPA and its five metabolites in human plasma using HPLC-MS/MS was developed for the first time...
November 16, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29169106/the-transcriptomic-changes-of-huipizhi-heidou-glycine-max-a-nematode-resistant-black-soybean-during-heterodera-glycines-race-3-infection
#7
Shuang Li, Yu Chen, Xiaofeng Zhu, Yuanyuan Wang, Ki-Hong Jung, Lijie Chen, Yuanhu Xuan, Yuxi Duan
Glycine max (soybean) is an extremely important crop, representing a major source of oil and protein for human beings. Heterodera glycines (soybean cyst nematode, SCN) infection severely reduces soybean production; therefore, protecting soybean from SCN has become an issue for breeders. Black soybean has exhibited a different grade of resistance to SCN. However, the underlying mechanism of Huipizhi Heidou resistance against SCN remains elusive. The Huipizhi Heidou (ZDD2315) and race 3 of Heterodera glycines were chosen to study the mechanism of resistance via examination of transcriptomic changes...
November 14, 2017: Journal of Plant Physiology
https://www.readbyqxmd.com/read/29169102/a-novel-framework-to-evaluate-pedestrian-safety-at-non-signalized-locations
#8
Ting Fu, Luis Miranda-Moreno, Nicolas Saunier
This paper proposes a new framework to evaluate pedestrian safety at non-signalized crosswalk locations. In the proposed framework, the yielding maneuver of a driver in response to a pedestrian is split into the reaction and braking time. Hence, the relationship of the distance required for a yielding maneuver and the approaching vehicle speed depends on the reaction time of the driver and deceleration rate that the vehicle can achieve. The proposed framework is represented in the distance-velocity (DV) diagram and referred as the DV model...
November 20, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/29169099/exposure-to-arsenic-in-tap-water-and-gestational-diabetes-a-french-semi-ecological-study
#9
Cécile Marie, Stéphanie Léger, Aline Guttmann, Olivier Rivière, Nathalie Marchiset, Didier Lémery, Françoise Vendittelli, Marie-Pierre Sauvant-Rochat
INTRODUCTION: The increase in the prevalence of gestational diabetes mellitus (GDM) and its consequences for mother and children prompts research on their risk factors including environmental factors. Studies on exposure to arsenic (As) in tap water and the risk of GDM have not provided conclusive evidence, particularly when levels of exposure were low (from 10 to 50µg As/L). The main objective of this study was to assess the association between exposure to As in tap water and the risk of GDM...
November 20, 2017: Environmental Research
https://www.readbyqxmd.com/read/29169095/bioactivity-and-properties-of-an-adhesive-system-functionalized-with-an-experimental-niobium-based-glass
#10
Karina Kato Carneiro, Taylan Pinheiro Araujo, Edilausson Moreno Carvalho, Marcia Margarete Meier, Auro Tanaka, Ceci Nunes Carvalho, José Bauer
OBJECTIVE: This study evaluated the incorporation of niobophosphate bioactive glass (NbG) fillers into a commercial adhesive resin. MATERIALS AND METHODS: The silanized (NbGs) or non-silanized (NbG) NbG was added to the commercial adhesive system One Step (OS) at 30% by weight; unfilled adhesive served as control. The bioactivity of adhesives was analyzed by SEM and FTIR/ATR after 28 days in PBS. The adhesives were evaluated as regards microtensile bond strength immediately and after six months (n = 6); degree of conversion (n = 3), microhardness (n = 5); and radiopacity (n = 3)...
November 10, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29169088/systematically-investigating-the-impact-of-medication-on-the-gut-microbiome
#11
REVIEW
Lisa Maier, Athanasios Typas
In the recent years, there is accumulating evidence for a strong impact of medication on the gut microbiota composition. This evidence comes from metagenomics-based associations and extends beyond classical antibacterials to a handful of human-targeted drugs. To answer whether such effects are direct and explore their consequences in human health, we need to develop experimental platforms that will allow for systematic profiling of drug-microbiota interactions. Here, we discuss approaches, considerations, experimental setups and strategies that can be used to tackle this need, but can be also readily transmitted to related questions in the microbiome field...
November 20, 2017: Current Opinion in Microbiology
https://www.readbyqxmd.com/read/29169087/antimicrobial-discovery-inspired-by-ecological-interactions
#12
REVIEW
Evelyn M Molloy, Christian Hertweck
Bacteria represent an unparalleled source of antibiotics used to treat infectious diseases. Yet, genome analyses have revealed that their full biosynthetic potential is much larger than expected. Valuable strategies to unearth hidden antibiotics are genome mining, pathway engineering and triggering, as well as co-cultivation approaches. Nevertheless, there is growing understanding that it is often essential to consider the ecological context and that there is a great potential for antimicrobial discovery from bacteria engaged in well-defined interactions with other organisms...
November 20, 2017: Current Opinion in Microbiology
https://www.readbyqxmd.com/read/29169085/combined-toxicity-of-triclosan-2-4-dichlorophenol-and-2-4-6-trichlorophenol-to-zebrafish-danio-rerio
#13
Yuhuan Zhang, Mi Liu, Jinfeng Liu, Xuedong Wang, Caihong Wang, Weiming Ai, Shaobo Chen, Huili Wang
Triclosan (TCS), 2,4,6-trichlorophenol (2,4,6-TCP) and 2,4-dichlorophenol (2,4-DCP) are the most prevalent chlorinated phenolic pollutants in aquatic environments. Our results showed LC50 and EC50 values of 0.51, 1.11, 2.45mg/L, and 0.36, 0.74, 1.53mg/L for TCS, 2,4,6-TCP and 2,4-DCP, respectively, to 120hpf zebrafish. The highest TCSD (the mixture of TCS, 2,4,6-TCP and 2,4-DCP) toxicity was observed at a TCS:2,4,6-TCP:2,4-DCP concentration ratio of 1:2:4. LC50 and EC50 values of TCSD mixtures for 120-hpf zebrafish were 2...
November 20, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29169079/design-synthesis-and-molecular-docking-of-thiazolidinedione-based-benzene-sulphonamide-derivatives-containing-pyrazole-core-as-potential-anti-diabetic-agents
#14
Mohd Javed Naim, Ozair Alam, Md Jahangir Alam, Md Quamrul Hassan, Nadeem Siddiqui, V G M Naidu, Md Iqbal Alam
We herein report the design, synthesis and molecular docking studies of 2,4-thiazolidinedione derivatives containing benzene sulphonyl group which are docked against the Peroxisome Proliferator Activated Receptor (PPARγ) target. Compound 7p was most effective in lowering the blood glucose level as compared to standard drugs pioglitazone and rosiglitazone. Compound 7p exhibited potent PPAR-γ transactivation of 61.2% with 1.9 folds increase in gene expression. In molecular docking studies 7p showed excellent interactions with amino acids TYR 473, SER 289, HIE 449, TYR 327, ARG 288, MET 329 and LEU 228...
November 16, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29169074/flow-stagnation-volume-and-abdominal-aortic-aneurysm-growth-insights-from-patient-specific-computational-flow-dynamics-of-lagrangian-coherent-structures
#15
Florian Joly, Gilles Soulez, Damien Garcia, Simon Lessard, Claude Kauffmann
Abdominal aortic aneurysms (AAA) are localized, commonly-occurring dilations of the aorta. When equilibrium between blood pressure (loading) and wall mechanical resistance is lost, rupture ensues, and patient death follows, if not treated immediately. Experimental and numerical analyses of flow patterns in arteries show direct correlations between wall shear stress and wall mechano-adaptation with the development of zones prone to thrombus formation. For further insights into AAA flow topology/growth interaction, a workout of patient-specific computational flow dynamics (CFD) is proposed to compute finite-time Lyapunov exponents and extract Lagrangian-coherent structures (LCS)...
November 6, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29169061/measurement-of-cross-sections-for-14mev-neutron-interaction-with-175-lu
#16
Zhengwei Zhang, Qian Zhang, Shihong Chen, Bingjun Chen, Qiang Wang, Caifeng Lai, Kaihong Fang
The cross-sections for 14MeV neutron interaction with (175)Lu were precisely measured by the neutron activation and off-line gamma ray technique. The neutron fluence was monitored by the accompanying α-particle of the T(d,n)α reaction, and the neutron energies were determined by using the cross-section ratio method of (90)Zr(n,2n)(89)Zr to (93)Nb(n,2n)(92m)Nb reactions. As a result, the cross-sections of (175)Lu(n,2n)(174m)Lu, (175)Lu(n,2n)(174g)Lu, (175)Lu(n,p)(175m+g)Yb and (175)Lu(n,α)(172)Tm reactions have been deduced at En = 14...
November 14, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/29169059/adsorption-of-ammonia-molecules-and-humidity-on-germanane-nanosheet-a-density-functional-study
#17
V Nagarajan, A Bhattacharyya, R Chandiramouli
The structural stability and electronic properties of pristine and Ga substituted germanane nanosheet were investigated using the density functional theory technique. The stability of bare and Ga substituted germanane nanosheet is substantiated with formation energy. The energy band gap opens upon hydrogenation on germanene sheet, which is utilized as a sensor material for the detection of NH3 and H2O molecules. The interaction of ammonia and humidity on germanane nanosheet is explored using the projected density of states, Bader charge transfer, adsorption energy, average energy gap variation, energy gap and electron density...
November 20, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/29169058/cyclic-di-amp-in-host-pathogen-interactions
#18
REVIEW
Laura Devaux, Pierre-Alexandre Kaminski, Patrick Trieu-Cuot, Arnaud Firon
Cyclic di-AMP (c-di-AMP) is a bacterial signaling nucleotide synthesized by several human pathogens. This widespread and specific bacterial product is recognized by infected host cells to trigger an innate immune response. Detection of c-di-AMP in the host cytosol leads primarily to the induction of type I interferon via the STING-cGAS signaling axis, while being also entangled in the activation of the NF-κB pathway. During their long-standing interaction, host and pathogens have co-evolved to control c-di-AMP activation of innate immunity...
November 20, 2017: Current Opinion in Microbiology
https://www.readbyqxmd.com/read/29169055/functional-electrical-stimulation-induced-muscular-fatigue-effect-of-fiber-composition-and-stimulation-frequency-on-rate-of-fatigue-development
#19
Maria Vromans, Pouran D Faghri
This investigation evaluated the progression towards fatigue in two muscles of differing fast- and slow-twitch fiber proportions (abductor pollicis brevis (APB) and vastus lateralis (VL)) when activated by functional electrical stimulation (FES) at three frequencies (10, 35, and 50 Hz). Fatigue was defined as a 50% drop from the initial FES-induced force of 25% maximal voluntary contraction (MVC). Ten healthy adults (mean age: 23.2 ± 3.0 years) were recruited; participants signed an IRB approved consent form prior to participation...
November 20, 2017: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/29169053/titania-lignin-hybrid-materials-as-a-novel-support-for-%C3%AE-amylase-immobilization-a-comprehensive-study
#20
Łukasz Klapiszewski, Jakub Zdarta, Teofil Jesionowski
α-Amylase from Aspergillus oryzae was immobilized via covalent bonds and by physical interactions on a synthesized titania/lignin novel hybrid support. A temperature of 5°C, a pH of 7.0, an initial enzyme solution concentration of 3.0mg/mL and a 3h process duration were found to be optimal for the highest activity of the immobilized enzyme. Moreover, the effect of temperature, pH, storage time and repeated catalytic cycles on the activity of free and immobilized enzyme was examined. Bound α-amylase showed enhanced thermal and chemical stability, and its reusability was also improved...
November 20, 2017: Colloids and Surfaces. B, Biointerfaces
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