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EBV, Duodenal Carcinoma

Toshiyuki Takahashi, Takayuki Morita, Yoshihiro Matsuno
The coexistent occurrence of a lymphoid neoplasm with adenocarcinoma of the stomach is rare. We report herein a case of gastroduodenal extramedullary plasmacytoma simultaneously complicated by multiple gastric Epstein-Barr virus (EBV)-associated adenocarcinomas. The patient underwent distal gastrectomy to treat an adenocarcinoma occupying the gastric antrum. Histopathological examination revealed a massive submucosal plasma cell proliferation adjacent to the adenocarcinoma involving the pylorus to the duodenal bulb...
July 26, 2016: International Journal of Surgical Pathology
Prachi Sharma, Joyce K Cohen, Katherine S Paul, Cynthia L Courtney, Zachary P Johnson, Daniel C Anderson
Sooty mangabeys (Cercocebus atys) are native to West Africa and are a natural host of SIV, which is implicated in the origin of HIV2. They have been used in studies of AIDS pathogenesis, leprosy, immune responses, reproductive biology, and behavior. Spontaneous tumors have rarely been reported in this species. However, we noted spontaneous gastric carcinomas in 8 sooty mangabeys. Four male and 4 female mangabeys had mild to severe chronic weight loss, with abdominal distention in 5 of 8 animals. At necropsy, 7 of the 8 mangabeys had prominent large ulcerated masses with severe, diffuse thickening of the pyloric wall at or near the gastric-duodenal junction, which often partially occluded the gastric lumen...
December 2011: Comparative Medicine
Ba D Nguyen, Panol C Ram, Michael C Roarke
Compared with the general population, solid organ transplant recipients, including renal transplant patients, who are under long-term immunosuppression, present with up to a 120-fold increased risk of developing skin cancer and non-Hodgkin lymphoma. For the renal transplant population with prior long-term dialysis, there is also an enhanced potentiality of native kidney malignancy. The authors present a case with a posttransplant lymphoproliferative disorder of the duodenum and concomitant left native papillary renal cell carcinoma...
April 2006: Clinical Nuclear Medicine
Claudio Ponticelli, Patrizia Passerini
Gastrointestinal complications are frequent in renal transplant recipients and can include oral lesions, esophagitis, peptic ulcer, diarrhea, colon disorders and malignancy. Oral lesions may be caused by drugs such as cyclosporine and sirolimus, by virus or fungal infections. Leukoplakia may develop in patients with Epstein-Barr virus (EBV) infection. The commonest esophageal disorder is represented by fungal esophagitis usually caused by candida. A number of patients may suffer from nausea, vomiting and gastric discomfort...
June 2005: Transplant International: Official Journal of the European Society for Organ Transplantation
Y A Luqmani, S O Linjawi, S Shousha
Epstein Barr virus (EBV) has been reported to be present in a minority of gastric carcinomas and may be implicated in its pathogenesis. This study was aimed at determining the occurrence of EBV in 43 consecutive gastrectomy specimens with a variety of benign and malignant lesions. In situ hybridisation was used for detection of EBER RNA, the marker for latent EBV infection. Only 1/20 (5%) gastric cancers was EBER positive; a moderately differentiated adenocarcinoma with a heavy lymphocytic infiltration. The interstitial lymphocytic infiltrate was predominantly of B cell type, but the majority of lymphocytes overlying the tumour cells were CD8+ T cells...
September 2001: Oncology Reports
M Daibata, Y Nemoto, N Komatsu, H Machida, I Miyoshi, H Taguchi
We describe a family with an inherited constitutional chromosome translocation (3;11) (p21;q23). Of three proven translocation carriers, one had duodenal malignant lymphoma (B-cell diffuse lymphoma, medium-sized cell type). The t(3;11)(p21;q23) was detected not only in hematopoietic cells including the patient's lymphoma cells, non-pathological bone marrow, and phytohemagglutinin-stimulated peripheral blood, but also in fibroblasts of the skin. We have successfully established an Epstein-Barr virus-transformed B-cell line and a Herpesvirus saimiri-transformed T-cell line from the patient, and found that both cell lines also carried this translocation...
February 2000: Cancer Genetics and Cytogenetics
M J Carey, L J Medeiros, J E Roepke, C R Kjeldsberg, K S Elenitoba-Johnson
We describe the clinicopathologic, immunophenotypic, and molecular findings in 4 cases of anaplastic large cell lymphoma (ALCL) arising in the small intestine. All patients were men with acute symptoms of gastrointestinal tract obstruction. The clinical preoperative diagnosis was gastrointestinal carcinoma in 3 cases, and pancreatic carcinoma in 1 case. Histologic examination revealed cohesive aggregates of neoplastic cells, with multiple vesicular nuclei, prominent nucleoli, and abundant amphophilic cytoplasm...
November 1999: American Journal of Clinical Pathology
S Shousha, Y A Luqmani
AIM: To look for Epstein-Barr virus (EBV) in a series of gastric cancers of common and rare histological types. METHODS: Formalin sections from 19 cases of gastric carcinomas of different types were studied using in situ hybridisation with fluorescein conjugated EBER oligonucleotides and the avidin-biotin complex immunoperoxidase technique, using the monoclonal antibody Dako-EBV CS 1-4. RESULTS: The only positive tumour was a lymphoepithelioma-like gastric carcinoma...
August 1994: Journal of Clinical Pathology
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