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EBV, Cancer

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https://www.readbyqxmd.com/read/28323751/long-term-nitrite-inhalant-exposure-and-cancer-risk-in-men-who-have-sex-with-men-a-prospective-cohort-study
#1
Anupriya Dutta, Hajime Uno, Alex Holman, David R Lorenz, Steven M Wolinsky, Dana Gabuzda
OBJECTIVES: Nitrite inhalants (poppers) are commonly used recreational drugs among men who have sex with men (MSM) and were previously associated with elevated rates of high-risk sexual behavior, HIV and HHV-8 seroconversion, and transient immunosuppressive effects in experimental models. Whether long-term popper use is associated with cancer risk among MSM in the HAART era is unclear. DESIGN: Prospective cohort study of cancer risk in 3223 HIV-infected and -uninfected MSM in the Multicenter AIDS Cohort Study from 1996-2010...
March 18, 2017: AIDS
https://www.readbyqxmd.com/read/28300576/clinical-significance-of-spasmolytic-polypeptide-expressing-metaplasia-and-intestinal-metaplasia-in-ebv-associated-and-ebv-negative-gastric-cancer
#2
Yu Zhang, Jian-Ning Chen, Min Dong, Zhi-Gang Zhang, Yi-Wang Zhang, Jun-Yan Wu, Hong Du, Hai-Gang Li, Yan Huang, Chun-Kui Shao
Spasmolytic polypeptide-expressing metaplasia (SPEM) and intestinal metaplasia (IM) have been recognized as neoplastic precursors in gastric carcinogenesis. We explored the relationship between SPEM and IM in Epstein-Barr virus-associated (EBVaGC) and Epstein-Barr virus-negative (EBVnGC) gastric cancer. 64 EBVaGC and 154 EBVnGC patients were included. EBV-positivity was identified using EBER-1 in situ hybridization. SPEM was sub-classified into absent, early and advanced SPEM. Acute and chronic inflammation was graded as absent, mild, moderate and marked...
March 11, 2017: Human Pathology
https://www.readbyqxmd.com/read/28298901/unveiling-another-missing-piece-in-ebv-driven-lymphomagenesis-ebv-encoded-micrornas-expression-in-eber-negative-burkitt-lymphoma-cases
#3
Lucia Mundo, Maria R Ambrosio, Matteo Picciolini, Giuseppe Lo Bello, Sara Gazaneo, Leonardo Del Porro, Stefano Lazzi, Mohsen Navari, Noel Onyango, Massimo Granai, Cristiana Bellan, Giulia De Falco, Davide Gibellini, Pier P Piccaluga, Lorenzo Leoncini
Epstein-Barr virus (EBV) is a gammaherpesvirus linked to a number of lymphoid and epithelial malignancies, including Burkitt lymphoma (BL) in which its frequency ranges from 30% in sporadic cases to 100% in the endemic ones. The possible contribution of EBV to BL pathogenesis is largely unknown. It has been suggested that EBV may be associated with all of the cases, including those diagnosed as EBV negative by a mechanism of hit-and-run. Early during oncogenesis, viral genes are essential for initiating disease...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28276306/designing-an-effective-vaccine-to-prevent-epstein-barr-virus-associated-diseases-challenges-and-opportunities
#4
Vijayendra Dasari, Kunal H Bhatt, Corey Smith, Rajiv Khanna
Epstein-Barr virus (EBV) is a ubiquitous herpesvirus associated with a number of clinical manifestations. Primary EBV infection in young adolescents often manifests as acute infectious mononucleosis and latent infection is associated with multiple lymphoid and epithelial cancers and autoimmune disorders, particularly multiple sclerosis. Areas covered: Over the last decade, our understanding of pathogenesis and immune regulation of EBV-associated diseases has provided an important platform for the development of novel vaccine formulations...
April 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/28276007/investigation-on-the-association-between-thyroid-tumorigeneses-and-herpesviruses
#5
J F M Almeida, A H Campos, M A Marcello, N E Bufalo, C L Rossi, L H P Amaral, A B Marques, L L Cunha, C A Alvarenga, P C Tincani, A J Tincani, L S Ward
Herpesviruses have been associated with various human malignancies and with thyroid autoimmunity. Aiming to investigate the presence of these viruses in thyroid nodules, we analyzed serum and thyroid tissue from 183 patients (83 benign and 100 malignant thyroid nodules). We also obtained 104 normal thyroid tissues extracted from the contralateral lobe of these patients. We used ELISA to screen the serology of all patients and a real-time quantitative PCR to analyze thyroid tissue viral load in antibody-positive patients...
March 8, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28271981/understanding-epstein-barr-virus-life-cycle-with-proteomics-a-temporal-analysis-of-ubiquitination-during-virus-reactivation
#6
Dong-Wen Lv, Jun Zhong, Kun Zhang, Akhilesh Pandey, Renfeng Li
Epstein-Barr virus (EBV) is a human γ-herpesvirus associated with cancer, including Burkitt lymphoma, nasopharyngeal, and gastric carcinoma. EBV reactivation in latently infected B cells is essential for persistent infection whereby B cell receptor (BCR) activation is a physiologically relevant stimulus. Yet, a global view of BCR activation-regulated protein ubiquitination is lacking when EBV is actively replicating. We report here, for the first time, the long-term effects of IgG cross-linking-regulated protein ubiquitination and offer a basis for dissecting the cellular environment during the course of EBV lytic replication...
January 2017: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/28264674/epstein-barr-virus-and-cytomegalovirus-infections-and-their-clinical-relevance-in-egyptian-leukemic-pediatric-patients
#7
Samah Aly Loutfy, Maha A Abo-Shadi, Mohamed Fawzy, Mohamed El-Wakil, Shimaa A Metwally, Manar M Moneer, Nasra F Abdel Fattah, Sara Kassem, Ahmed Elgebaly
BACKGROUND: Epstein-Barr virus (EBV) and human cytomegalovirus (CMV) infections are environmental risk factors affecting the outcome of cancer due to an impairment in the cell-mediated immunity. Therefore, this study aimed to detect the frequency of EBV and CMV DNA and their association with clinical characteristics and outcome of pediatric leukemic patients. METHODS: Samples of 50 immunocompromised pediatric leukemic patients and 30 apparently healthy children were subjected to the amplification of EBV DNA by one version of PCR targeting the Bam H1 W region of the genomic region of EBV, and the amplification of CMV DNA by targeting the CMV UL97 genomic region by a second round PCR...
March 6, 2017: Virology Journal
https://www.readbyqxmd.com/read/28259949/berberine-inhibits-the-proliferation-of-human-nasopharyngeal-carcinoma-cells-via-an-epstein-barr-virus-nuclear-antigen%C3%A2-1-dependent-mechanism
#8
Chao Wang, Huan Wang, Yaqian Zhang, Wei Guo, Cong Long, Jingchao Wang, Limei Liu, Xiaoping Sun
Nasopharyngeal carcinoma (NPC) is a malignancy derived from the epithelial cells of the nasopharynx cavity, and is closely associated with Epstein-Barr virus (EBV) infection. In addition to NPC, EBV causes various human malignancies, such as gastric cancer, hematological tumors and lymphoepithelioma-like carcinomas. Epstein-Barr nuclear antigen 1 (EBNA1) encoded by EBV is indispensable for replication, partition, transcription and maintenance of viral genomes. Berberine, a naturally occurring isoquinoline alkaloid, shows anti-inflammatory, anticholinergic, antioxidative, and anticancer activities...
March 2, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28252462/the-prevalence-of-viral-agents-in-esophageal-adenocarcinoma-and-barrett-s-esophagus-a-systematic-review
#9
Andrew T Kunzmann, Suzanne Graham, Charlene M McShane, James Doyle, Massimo Tommasino, Brian Johnston, Jackie Jamison, Jacqueline A James, Damian McManus, Lesley A Anderson
BACKGROUND AND AIMS: Human papilloma virus (HPV), which may reach the esophagus through orogenital transmission, has been postulated to be associated with esophageal adenocarcinoma (EAC). A systematic review of the literature investigating the prevalence of infectious agents in EAC and Barrett's esophagus (BE) was carried out. METHODS: Using terms for viruses and EAC, the Medline, Embase, and Web of Science databases were systematically searched for studies published, in any language, until June 2016 that assessed the prevalence of viral agents in EAC or BE...
March 1, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28247637/-oncogenetic-factors-of-some-herpesvirus-infection-agents
#10
I V Kosova
Currently, debate continues about the etiological role of pathogens, in particular viruses, in the development of bladder tumors, their impact on the rate of recurrence and invasive and metastatic forms. The literature has reported some evidence for oncomodulating effect of cytomegalovirus in glioblastomas and bowel tumors. There is the possible role of herpes simplex virus (HSV) type 2 as carcinogenesis cofactor that initiates the development of dysplasia and maintains it in a stable condition. Epstein - Barr virus (EBV) from a family of the oncogenic DNA viruses is associated with an increasing range of cancers...
August 2016: Urologii︠a︡
https://www.readbyqxmd.com/read/28243335/the-epstein-barr-virus-encoded-mir-bart22-targets-map3k5-to-promote-host-cell-proliferative-and-invasive-abilities-in-nasopharyngeal-carcinoma
#11
Ruichao Chen, Minfeng Zhang, Qiulian Li, Hanzhen Xiong, Shaoyan Liu, Weiyi Fang, Qianbing Zhang, Zhen Liu, Xuehu Xu, Qingping Jiang
miR-BART22, a new discovered Epstein-Barr virus (EBV) miRNA, is abundant in Nasopharyngeal carcinoma (NPC). It has been reported that miR-BART22 promoted the tumor development by down-modulating EBV LMP2 expression to evade the host immune response. But its cell target genes have still been obscure. We have reported an inverse correlation between the BART-22 and MAP3K5 protein expression in NPC tissues and NPC cell lines. Meanwhile, MAP3K5 protein expression level was significantly decreased in primary NPC tissues compared with nasopharyngitis when MAP3K5 mRNA expression was consistent in two group tissues...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28240350/oncogenic-s1p-signalling-in-ebv-associated-nasopharyngeal-carcinoma-activates-akt-and-promotes-cell-migration-through-s1p-receptor-3
#12
Hui Min Lee, Kwok-Wai Lo, Wenbin Wei, Sai Wah Tsao, Grace Tin Yun Chung, Maha Hafez Ibrahim, Christopher W Dawson, Paul G Murray, Ian C Paterson, Lee Fah Yap
Undifferentiated nasopharyngeal carcinoma (NPC) is a cancer with high metastatic potential that is consistently associated with Epstein-Barr virus (EBV) infection. In this study, we have investigated the functional contribution of sphingosine-1-phosphate (S1P) signalling to the pathogenesis of NPC. We show that EBV infection or ectopic expression of the EBV-encoded latent genes (EBNA1, LMP1 and LMP2A) can up-regulate sphingosine kinase 1 (SPHK1), the key enzyme that produces S1P, in NPC cell lines. Exogenous addition of S1P promotes the migration of NPC cells through the activation of AKT; shRNA knockdown of SPHK1 resulted in a reduction in the levels of activated AKT and inhibition of cell migration...
February 27, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/28229344/variation-in-risk-and-outcomes-of-epstein-barr-virus-associated-breast-cancer-by-epidemiologic-characteristics-and-virus-detection-strategies-an-exploratory-study
#13
Sally L Glaser, Alison J Canchola, Theresa H M Keegan, Christina A Clarke, Teri A Longacre, Margaret L Gulley
PURPOSE: A relationship of Epstein-Barr virus (EBV) and breast cancer etiology and outcome may have clinical utility and potential to enhance understanding of tumor biology. Research to date has yielded variable results, likely reflecting differing virus detection assays and unaddressed epidemiologic heterogeneity across studies. METHODS: Applying our novel, five-target assay detection strategy in an exploratory study, we examined demographic, clinical, and tumor characteristics, and overall survival, associated with EBV positivity in breast adenocarcinomas from 59 non-Hispanic white and 68 Hispanic women sampled by age (<50, 50+) and stage (localized, regional/remote) and examined associations based on single assay targets...
February 22, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28222215/epstein-barr-virus-specific-adoptive-immunotherapy-for-recurrent-metastatic-nasopharyngeal-carcinoma
#14
Julian Huang, Mark Fogg, Lori J Wirth, Heather Daley, Jerome Ritz, Marshall R Posner, Fred C Wang, Jochen H Lorch
BACKGROUND: Early-stage and intermediate stage nasopharyngeal cancer (NPC) generally carry a good prognosis, but for patients with recurrent, metastatic disease, options are limited. In the current study, the authors present a phase 1/2 study to evaluate the efficacy of Epstein-Barr virus (EBV)-stimulated cytotoxic T-lymphocyte (EBV-CTL) immunotherapy in this patient population. METHODS: Screening for patients with active, recurrent, metastatic EBV-associated NPC began in February 2007, and the study was closed to accrual in January 2012...
February 21, 2017: Cancer
https://www.readbyqxmd.com/read/28210636/hemophagocytic-lymphohistiocytosis-in-a-patient-with-hodgkin-lymphoma-and-concurrent-ebv-cmv-and-candida-infections
#15
Moaath Mustafa Ali, Ana Lucia Ruano Mendez, Hetty E Carraway
Hemophagocytic lymphohistiocytosis (HLH) is a syndrome characterized by immune activation and subsequent widespread organ damage. Patients affected by HLH commonly develop fever, cytopenias, liver damage, neurologic manifestations, and hypercytokinemia. In this case, we describe a 60-year-old male who presented with HLH and concurrent Epstein-Barr virus, cytomegalovirus, and Candida infections and was subsequently diagnosed with a Hodgkin lymphoma. This case highlights the importance of considering a cancer diagnosis in the differential diagnosis of patients presenting with HLH...
January 2017: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/28205059/clinical-application-of-early-gastric-carcinoma-with-lymphoid-stroma-based-on-lymph-node-metastasis-status
#16
Hyun Lim, In Seob Lee, Jeong Hoon Lee, Young Soo Park, Hyo Jeong Kang, Hee Kyong Na, Ji Yong Ahn, Do Hoon Kim, Kee Don Choi, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung, Jin-Ho Kim, Beom Su Kim, Jeong Hwan Yook, Byung Sik Kim
BACKGROUND: Gastric carcinoma with lymphoid stroma (GCLS) is characterized by undifferentiated carcinoma mixed with prominent lymphoid infiltration. GCLS has unique clinicopathological features and a better prognosis compared to other types of gastric cancer. We analyzed the clinicopathological features of early GCLS in relation to lymph node metastasis (LNM). METHODS: We performed a retrospective analysis of 241 patients diagnosed with GCLS confined to the mucosa or the submucosa between March 1998 and December 2015...
February 15, 2017: Gastric Cancer
https://www.readbyqxmd.com/read/28197365/crispr-cas9-mediated-disruption-of-pd-1-on-human-t-cells-for-adoptive-cellular-therapies-of-ebv-positive-gastric-cancer
#17
Shu Su, Zhengyun Zou, Fangjun Chen, Naiqing Ding, Juan Du, Jie Shao, Lin Li, Yao Fu, Bian Hu, Yang Yang, Huizi Sha, Fanyan Meng, Jia Wei, Xingxu Huang, Baorui Liu
The successful use of immune cell checkpoint inhibitors PD-1 and PD-L1, over the past 5 y has raised the concern of using immunotherapy to treat various cancers. Epstein-Barr virus-associated gastric cancer (EBVaGC) exhibits high infiltration of lymphocytes and high amplification of immune-related genes including PD-L1 as distinguished from Epstein-Barr virus-non-associated gastric cancer (EBVnGC). Here, we presume that this PD-1/PD-L1 pathway may hinder the efficacy of adoptive T cell therapy toward EBVaGC...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28194453/a-paper-based-platform-for-detection-of-viral-rna
#18
Daohong Zhang, David Broyles, Eric A Hunt, Emre Dikici, Sylvia Daunert, Sapna K Deo
Viral detection presents a host of challenges for even the most sensitive analytical techniques, and the complexity of common detection platforms typically preclude portability. With these considerations in mind, we designed a paper microzone plate-based virus detection system for the detection of viral genetic material that can be performed with simple instruments. The sensing system can detect viral cDNA reverse-transcribed from total RNA extraction by utilizing a biotinylated capture probe and an Alexa Fluor® 647-labeled reporter probe...
February 27, 2017: Analyst
https://www.readbyqxmd.com/read/28192371/somatic-mutations-in-telomerase-promoter-counterbalance-germline-loss-of-function-mutations
#19
Lindley Maryoung, Yangbo Yue, Ashley Young, Chad A Newton, Cindy Barba, Nicolai S C van Oers, Richard C Wang, Christine Kim Garcia
Germline coding mutations in different telomere-related genes have been linked to autosomal-dominant familial pulmonary fibrosis. Individuals with these inherited mutations demonstrate incomplete penetrance of clinical phenotypes affecting the lung, blood, liver, skin, and other organs. Here, we describe the somatic acquisition of promoter mutations in telomerase reverse transcriptase (TERT) in blood leukocytes of approximately 5% of individuals with inherited loss-of-function coding mutations in TERT or poly(A)-specific ribonuclease (PARN), another gene linked to telomerase function...
March 1, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28186092/epstein-barr-virus-particles-induce-centrosome-amplification-and-chromosomal-instability
#20
Anatoliy Shumilov, Ming-Han Tsai, Yvonne T Schlosser, Anne-Sophie Kratz, Katharina Bernhardt, Susanne Fink, Tuba Mizani, Xiaochen Lin, Anna Jauch, Josef Mautner, Annette Kopp-Schneider, Regina Feederle, Ingrid Hoffmann, Henri-Jacques Delecluse
Infections with Epstein-Barr virus (EBV) are associated with cancer development, and EBV lytic replication (the process that generates virus progeny) is a strong risk factor for some cancer types. Here we report that EBV infection of B-lymphocytes (in vitro and in a mouse model) leads to an increased rate of centrosome amplification, associated with chromosomal instability. This effect can be reproduced with virus-like particles devoid of EBV DNA, but not with defective virus-like particles that cannot infect host cells...
February 10, 2017: Nature Communications
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