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ADHD and MTHFR

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https://www.readbyqxmd.com/read/23227261/folate-metabolism-gene-5-10-methylenetetrahydrofolate-reductase-mthfr-is-associated-with-adhd-in-myelomeningocele-patients
#1
Catherine J Spellicy, Hope Northrup, Jack M Fletcher, Paul T Cirino, Maureen Dennis, Alanna C Morrison, Carla A Martinez, Kit Sing Au
The objective of this study was to examine the relation between the 5, 10-methylenetetrahydrofolate reductase (MTHFR) gene and behaviors related to attention- deficit/hyperactivity disorder (ADHD) in individuals with myelomeningocele. The rationale for the study was twofold: folate metabolizing genes, (e.g. MTHFR), are important not only in the etiology of neural tube defects but are also critical to cognitive function; and individuals with myelomeningocele have an elevated incidence of ADHD. Here, we tested 478 individuals with myelomeningocele for attention-deficit hyperactivity disorder behavior using the Swanson Nolan Achenbach Pelham-IV ADHD rating scale...
2012: PloS One
https://www.readbyqxmd.com/read/21897766/methylenetetrahydrofolate-reductase-gene-polymorphisms-in-children-with-attention-deficit-hyperactivity-disorder
#2
COMPARATIVE STUDY
Cem Gokcen, Nadir Kocak, Ahmet Pekgor
OBJECTIVE: The purpose of this study was to evaluate the relationship between 5,10- methylenetetrahydrofolate reductase (MTHFR) polymorphisms and Attention Deficit Hyperactivity Disorder (ADHD) in a sample of Turkish children. STUDY DESIGN: MTHFR gene polymorphisms were assessed in 40 patients with ADHD and 30 healty controls. Two mutations in the MTHFR gene were investigated using polymerase chain reactions and restriction fragment length polymorphisms. RESULTS: Although there were no statistically significant differences in genotype distributions of the C677T alleles between the ADHD and the control groups (p=0,678) but the genotypic pattern of the distributions of the A1298C alleles was different between the ADHD patients and the controls (p=0,033)...
2011: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/21819229/methylenetetrahydrofolate-reductase-gene-polymorphisms-in-turkish-children-with-attention-deficit-hyperactivity-disorder
#3
Emel Ergul, Ali Sazci, Ihsan Kara
Attention-deficit/hyperactivity disorder (ADHD) is a common, multifactorial genetic disorder. The aim of the present study was to evaluate a possible association between 5,10-methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and ADHD. There is evidence to suggest that MTHFR C677T and A1298C polymorphisms alter the function of the enzyme, causing reduced folate and increased homocysteine levels in plasma. Two polymorphisms of the MTHFR gene, C677T (rs1801133) and A1298C (rs1801131), were analyzed in a sample of 100 Diagnostic and Statistical Manual of Mental Disorders-IV-diagnosed ADHD and 300 healthy controls using a polymerase chain reaction-restriction fragment length polymorphism method...
January 2012: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/20870238/genotyping-of-two-single-nucleotide-polymorphisms-in-5-10-methylenetetrahydrofolate-reductase-by-multiplex-polymerase-chain-reaction-and-capillary-electrophoresis
#4
Hui-Ling Cheng, Shyh-Shin Chiou, Yu-Mei Liao, Yen-Ling Chen, Shou-Mei Wu
Two single nucleotide polymorphisms (SNPs) of 5,10-methylenetetrahydrofolate reductase (MTHFR) gene, A1298C and C677T, were widely considered to be related with various neoplasia disorders. We established a simple and effective capillary electrophoresis (CE) method for detection of two SNPs in MTHFR gene simultaneously. DNA samples were amplified by multiplex PCR with universal fluorescence-labeled primer and analyzed by single-strand conformation polymorphism (SSCP)-CE method. The CE method was performed using 1...
April 15, 2011: Journal of Chromatography. A
https://www.readbyqxmd.com/read/18154909/folate-pathway-genetic-polymorphisms-are-related-to-attention-disorders-in-childhood-leukemia-survivors
#5
Kevin R Krull, Pim Brouwers, Neelam Jain, Linna Zhang, Lisa Bomgaars, ZoAnn Dreyer, Donald Mahoney, Sarah Bottomley, M Fatih Okcu
OBJECTIVE: To test the hypothesis that 5,10-methylenetetrahydroreductase (MTHFR) polymorphisms can partially explain the individual variation in developing attention-deficit/hyperactivity disorder (ADHD) after acute lymphoblastic leukemia (ALL) therapy. STUDY DESIGN: Parents of 48 survivors of childhood ALL completed a clinical diagnostic process to identify subtypes of ADHD. Genotyping was performed with peripheral blood DNA for MTHFR (C677T and A1298C) polymorphisms...
January 2008: Journal of Pediatrics
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