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JOURNAL ARTICLE
Janet Flores-Lujano, Aldo Allende-López, David Aldebarán Duarte-Rodríguez, Erika Alarcón-Ruiz, Lizbeth López-Carrillo, Teresa Shamah-Levy, Mariano E Cebrián, Ma Del Rocío Baños-Lara, Diana Casique-Aguirre, Jesús Elizarrarás-Rivas, Javier Antonio López-Aquino, Miguel Ángel Garrido-Hernández, Daniela Olvera-Caraza, Vanessa Terán-Cerqueda, Karina Beatriz Martínez-José, Pierre Mitchel Aristil-Chery, Enoch Alvarez-Rodríguez, Wilfrido Herrera-Olivares, Guillermo J Ruíz-Arguelles, Lénica Anahí Chavez-Aguilar, Aquilino Márquez-Toledo, Lena Sarahi Cano-Cuapio, Nuria Citlalli Luna-Silva, Maria Angélica Martínez-Martell, Anabel Beatriz Ramirez-Ramirez, Laura Elizabeth Merino-Pasaye, César Alejandro Galván-Díaz, Aurora Medina-Sanson, Maria de Lourdes Gutiérrez-Rivera, Jorge Alfonso Martín-Trejo, Emmanuel Rodriguez-Cedeño, Vilma Carolina Bekker-Méndez, María de Los Ángeles Romero-Tlalolini, Astin Cruz-Maza, Gerardo Juárez-Avendaño, Sonia Mayra Pérez-Tapia, Juan Carlos Rodríguez-Espinosa, Miriam Carmina Suárez-Aguirre, Fernando Herrera-Quezada, Anahí Hernández-Díaz, Lizbeth Alondra Galván-González, Minerva Mata-Rocha, Amanda Idaric Olivares-Sosa, Haydeé Rosas-Vargas, Silvia Jiménez-Morales, Mariana Cárdenas-González, María Elena Álvarez-Buylla Roces, Célida Duque-Molina, Rosana Pelayo, Juan Manuel Mejía-Aranguré, Juan Carlos Núñez-Enriquez
INTRODUCTION: Acute leukemias (AL) are the main types of cancer in children worldwide. In Mexico, they represent one of the main causes of death in children under 20 years of age. Most of the studies on the incidence of AL in Mexico have been developed in the urban context of Greater Mexico City and no previous studies have been conducted in the central-south of the country through a population-based study. The aim of the present work was to identify the general and specific incidence rates of pediatric AL in three states of the south-central region of Mexico considered as some of the marginalized populations of Mexico (Puebla, Tlaxcala, and Oaxaca)...
2024: Frontiers in Oncology
#22
Miguel Enrique Cuéllar Mendoza, Francisco Raúl Chávez Sánchez, Elisa María Dorantes Acosta, Ana María Niembro Zúñiga, Rosana Pelayo, Marta Zapata Tarrés
INTRODUCTION: The mechanistic/mammalian target of rapamycin (mTOR) is a serine/threonine kinase, which is downregulated or upregulated and is implicated in different types of cancer including hematologic neoplasms, skin prostate, and head and neck cancer. AIM: The aim of this study was to explore the current knowledge of mTOR signaling in acute lymphoblastic leukemia and Hodgkin lymphoma. METHODS: A systematic review was performed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, searching PubMed, Discovery Service for National Autonomous University of Mexico, Registro Nacional de Instituciones y Empresas Científicas y Tecnológicas (RENIECYT), and Scientific Electronic Library Online (SciELO) from 1994 to 2023...
2024: Frontiers in Oncology
#23
JOURNAL ARTICLE
Qian Liu, Tie Rong Bian, Zhi Yuan Li, Hong Yun Xing
INTRODUCTION: Flumatinib, a highly selective ABL kinase inhibitor, exhibits stronger inhibition of intracellular BCR-ABL tyrosine kinase activity, compared to Imatinib. However, there is limited research comparing the real-world efficacy and safety of flumatinib and dasatinib in patients with Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL). OBJECTIVE: Investigating the differences in therapeutic efficacy and safety between flumatinib and dasatinib in combination with multi-drug chemotherapy for the treatment of newly diagnosed Ph+ ALL...
February 20, 2024: Hematology, Transfusion and Cell Therapy
#24
REVIEW
José Costa, António Araújo
Although the relationship between venous thromboembolism (VTE) and cancer has been a subject of study, knowledge of the contribution of thrombophilia to thrombosis in patients with cancer is still very limited. The aim of this article is to collect present knowledge on the contribution of inherited thrombophilia to VTE in cancer patients. We performed a search in Google Scholar and PubMed and selected 21 from 76 returned articles. Then we made a narrative review of the selected articles. We describe 11 studies on the contribution of inherited thrombophilia to VTE in cancer patients in general and 10 on that contribution in specific types of cancer: 1 in colorectal cancer, 4 in breast cancer, 1 in gynecologic cancer and 4 in hematopoietic malignancies...
2024: Clinical and Applied Thrombosis/hemostasis
#25
REVIEW
Jadwiga Filipek-Gorzała, Patrycja Kwiecińska, Agata Szade, Krzysztof Szade
Hematopoietic stem cells (HSCs) produce all blood cells throughout the life of the organism. However, the high self-renewal and longevity of HSCs predispose them to accumulate mutations. The acquired mutations drive preleukemic clonal hematopoiesis, which is frequent among elderly people. The preleukemic state, although often asymptomatic, increases the risk of blood cancers. Nevertheless, the direct role of preleukemic HSCs is well-evidenced in adult myeloid leukemia (AML), while their contribution to other hematopoietic malignancies remains less understood...
2024: Frontiers in Oncology
#26
JOURNAL ARTICLE
Behnaz Valipour, Seyedeh Momeneh Mohammadi, Ali Abedelahi, Hojjatollah Nozad Charoudeh
Fortunately, ample efforts are being made to find the best strategy to improve the anti-leukemia capacity of NK cells for treating different types of cancer. Despite the favorable ADCC capacity of functional CD16 + NK cells for immunotherapy, when NK cells face leukemia cells, the CD16 receptor is cleaved during the process mediated by a disintegrin and metalloproteinase-17(ADAM17). Reduced CD16 expression on NK cells weakens their cytotoxicity against leukemia cells. In addition, the expression of the CD47 receptor is high in acute lymphoblastic leukemia (ALL) compared to normal cells and can be correlated with poor prognosis...
February 29, 2024: Human Immunology
#27
JOURNAL ARTICLE
Cesar Cobaleda, Lucy A Godley, Kim E Nichols, Marcin W Wlodarski, Isidro Sanchez-Garcia
The recognition of host genetic factors underlying susceptibility to hematopoietic malignancies has increased greatly over the last decade. Historically, germline predisposition was thought to primarily affect the young. However, emerging data indicate that hematopoietic malignancies that develop in people of all ages across the human lifespan can derive from germline predisposing conditions and are not exclusively observed in younger individuals. The age at which hematopoietic malignancies manifest appears to correlate with distinct underlying biological pathways...
March 1, 2024: Cancer Discovery
#28
JOURNAL ARTICLE
Yuka Shiozawa, Shinya Fujita, Yasuhito Nannya, Seishi Ogawa, Naho Nomura, Toru Kiguchi, Nobuo Sezaki, Himari Kudo, Takaaki Toyama
While our understanding of the molecular basis of mixed phenotype acute leukemia (MPAL) has progressed over the decades, our knowledge is limited and the prognosis remains poor. Investigating cases of familial leukemia can provide insights into the role of genetic and environmental factors in leukemogenesis. Although familial cases and associated mutations have been identified in some leukemias, familial occurrence of MPAL has never been reported. Here, we report the first cases of MPAL in a family. A 68-year-old woman was diagnosed with MPAL and received haploidentical stem cell transplantation from her 44-year-old son...
February 29, 2024: International Journal of Hematology
#29
JOURNAL ARTICLE
Mai Itoh, Shun Sasaki, Shuji Tohda
BACKGROUND/AIM: The renin-angiotensin system (RAS) regulates blood pressure. The RAS is also related to cell growth, and its activation has been reported in various cancer cells. Therefore, we investigated the effects of RAS inhibitors on the in vitro growth of leukemia cell lines. MATERIALS AND METHODS: THP-1, MV4-11, and TMD7 cells derived from acute myeloid leukemia, K-562 cells from chronic myeloid leukemia, and Jurkat and KOPT-K1 cells from T-lymphoblastic leukemia (T-ALL) with NOTCH1 mutations were used...
March 2024: Anticancer Research
#30
JOURNAL ARTICLE
Qianze Dong, Tarneem Darwish, Meyerson Howard, Shashirekha Shetty, Yang Wang, Yan Xiu, Molly Gallogly, Chen Zhao
Philadelphia chromosome-positive (Ph+) T-cell acute lymphoblastic leukemia (T-ALL) is a rare and aggressive type of acute leukemia. The Philadelphia chromosome is the hallmark of chronic myeloid leukemia (CML). The differentiation between Ph+ T-ALL and T-cell lymphoblastic crisis of CML may be problematic in some cases. Here, we report a rare case of de novo Ph+ T-ALL that presented a diagnostic challenge. The overall clinical, immunophenotypic, cytogenetic, and xenotransplantation results suggest a diagnosis of Ph+ T-ALL...
February 2024: Journal of International Medical Research
#31
JOURNAL ARTICLE
Shahina Raushan Saikh, Md Abu Mushtaque, Antara Pramanick, Jashvant Kumar Prasad, Dibakar Roy, Sudipto Saha, Sanat Kumar Das
Fog causes enhancement of bacterial loading in the atmosphere. Current study represents the impact of occurrences of fog on the alteration of diversity of airborne bacteria and their network computed from metagenomic data of airborne samples collected at Arthauli (25.95°N, 85.10°E) situated at central Indo-Gangetic Plain (IGP) during 1-14 January 2021. A distinct bacterial diversity with a complex network is identified in foggy condition due to the enrichment of unique types of bacteria. Present investigation highlights a statistically significant enrichment of airborne pathogenic bacteria found in a unique ecosystem within air evolved due to the occurrences of fog over central IGP...
February 29, 2024: Heliyon
#32
JOURNAL ARTICLE
Soumika Sengupta, Mainak Biswas, Khushboo A Gandhi, Saurabh Kumar Gupta, Poonam B Gera, Vikram Gota, Avinash Sonawane
INTRODUCTION: Escherichia coli l-asparaginase (EcA), an integral part of multi-agent chemotherapy protocols of acute lymphoblastic leukemia (ALL), is constrained by safety concerns and the development of anti-asparaginase antibodies. Novel variants with better pharmacological properties are desirable. METHODS: Thousands of novel EcA variants were constructed using protein engineering approach. After preliminary screening, two mutants, KHY-17 and KHYW-17 were selected for further development...
February 26, 2024: Translational Oncology
#33
REVIEW
Hiroshi Hayashi, Atsushi Makimoto, Yuki Yuza
Acute lymphoblastic leukemia (ALL) is the most common disease in pediatric oncology. The history of developmental therapeutics for ALL began in the 1960s with the repetition of "unreliable" medical interventions against this lethal disease. By the 1990s, the development of multi-agent chemotherapy and various types of supportive care rendered ALL treatable. Highly sophisticated, molecular, diagnostic techniques have enabled highly accurate prediction of the relapse risk, and the application of risk-adapted treatments has increased the survival rate in the standard-risk group to nearly 100% in most European nations and North America...
February 8, 2024: Cancers
#34
JOURNAL ARTICLE
Hyun Jae Cho, Zhenjia Wang, Yidan Cong, Stefan Bekiranov, Aidong Zhang, Chongzhi Zang
Characterization of gene regulatory mechanisms in cancer is a key task in cancer genomics. CCCTC-binding factor (CTCF), a DNA binding protein, exhibits specific binding patterns in the genome of cancer cells and has a non-canonical function to facilitate oncogenic transcription programs by cooperating with transcription factors bound at flanking distal regions. Identification of DNA sequence features from a broad genomic region that distinguish cancer-specific CTCF binding sites from regular CTCF binding sites can help find oncogenic transcription factors in a cancer type...
January 23, 2024: Genes
#35
JOURNAL ARTICLE
Inge van Outersterp, Sarah K Tasian, Caitlin Ej Reichert, Aurélie Boeree, Hester A de Groot-Kruseman, Gabriele Escherich, Judith M Boer, Monique L den Boer
Acute lymphoblastic leukemia (ALL) with fusions of ABL-class tyrosine kinase genes other than BCR::ABL1 occurs in approximately 3% of children with ALL. The tyrosine kinase genes involved in this BCR::ABL1-like (Ph-like) subtype include ABL1, PDGFRB, ABL2, and CSF1R, which each have up to ten described partner genes. ABL-class ALL resembles BCR::ABL1-positive ALL by a similar gene expression profile, a poor response to chemotherapy, and sensitivity to tyrosine kinase inhibitors (TKIs). There is a lack of comprehensive data regarding TKI sensitivity for the heterogeneous group of ABL-class ALL...
February 23, 2024: Blood
#36
JOURNAL ARTICLE
Abdulrhman S Elbnnani, Mohamed Elbasir, Salah Altabal, Yosra Lamami, Fawzi Ebrahim, Hakema M Oshah, Rasem Alagnef, Adam Elzagheid, Abdulmunem M Abulayha
The diagnosis of acute lymphoblastic leukemia (ALL), which is the most common type of cancer in children, has become more accurate with the use of flow cytometry. Here, this technology was used to immunophenotype leukemic cells in peripheral blood samples from Libyan pediatric ALL patients. We recruited 152 newly diagnosed patients at Tripoli Medical Center (Tripoli, Libya) by morphological examination of blood and bone marrow. Twenty-three surface and cytoplasmic antigen markers were used to characterize B and T cells in circulating blood cells by four-color flow cytometry...
December 31, 2024: Libyan Journal of Medicine
#37
EDITORIAL
Khawla Magdoud, Saber Abouda Hassine, Sirine Bayar, Sana Menjli, Ghada Sahraoui, Karima Mrad
No abstract text is available yet for this article.
February 20, 2024: Journal of Obstetrics and Gynaecology Canada: JOGC
#38
JOURNAL ARTICLE
Hind Al Hajri, Widad Al-Salmi, Karima Al Hinai, Saif Al-Housni, Ahmed Al-Harrasi, Hilal Al Hashami, Abdullah M S Al-Hatmi
BACKGROUND AND PURPOSE: Invasive fungal disease (IFD) is a common and serious consequence of leukemia in children and the incidence of these infections has increased due to chemotherapy. This study aimed to present the epidemiology of IFD in a cohort of children with leukemia from a tertiary reference institution in Oman. MATERIALS AND METHODS: A retrospective study of IFDs in pediatric patients below 13 years of age with newly diagnosed or relapsed leukemia was conducted at the Royal Hospital in Muscat, Oman...
September 2023: Current Medical Mycology
#39
REVIEW
Leila Ahmadinia, Shahid B Rangrej, Maria Miranda, Christine Shailer, Waleed Ahmed, Victoria Carvalho, Rajni Rathore
Hematopoietic stem-cell transplantation (HSCT) has emerged as a groundbreaking therapeutic option for acute myeloid leukemia (AML) and specific subtypes of acute lymphoblastic leukemia (ALL). The prognostic significance of the NOD2/CARD15 gene has been explored alongside various factors, encompassing diverse patient cohorts and gene variants. Siblings and unrelated donors used for stem cell transplantation exhibit significant associations between their genetic variations and graft-versus-host disease incidence...
January 2024: Curēus
#40
JOURNAL ARTICLE
Xiaowen Li, Tong Wu, Weihong Chen, Jiannan Zhang, Yanping Jiang, Jianzhi Deng, Wenqing Long, Xi Qin, Yuehan Zhou
Acute lymphoblastic leukemia (ALL) is one of the most common malignant tumor types of the circulatory system. Dexamethasone (DEX) acts on the glucocorticoid (GC) receptor (GR) and is a first-line chemotherapy drug for ALL. However, long-term or high-dose applications of the drug can not only cause adverse reactions, such as osteoporosis and high blood pressure, but can also cause downregulation of GR and lead to drug resistance. In the present study, reverse transcription-quantitative PCR, western blotting and LysoTracker Red staining were used to observe the effects of DEX and andrographolide (AND; a botanical with antitumorigenic properties) combined treatment...
March 2024: Biomedical Reports
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