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https://www.readbyqxmd.com/read/29741373/anionic-dinuclear-oxidovanadium-iv-complexes-with-azo-functionalized-tridentate-ligands-and-%C3%AE-ethoxido-bridge-leading-to-an-unsymmetric-twisted-arrangement-synthesis-x-ray-structure-magnetic-properties-and-cytotoxicity
#1
Satabdi Roy, Michael Böhme, Subhashree P Dash, Monalisa Mohanty, Axel Buchholz, Winfried Plass, Sudarshana Majumder, Senthilguru Kulanthaivel, Indranil Banerjee, Hans Reuter, Werner Kaminsky, Rupam Dinda
The synthesis of ethoxido-bridged dinuclear oxidovanadium(IV) complexes of the general formula (HNEt3 )[(VOL1-3 )2 (μ-OEt)] (1-3) with the azo dyes 2-(2'-carboxy-5'-X-phenylazo)-4-methylphenol (H2 L1 , X = H; H2 L2 , X = NO2 ) and 2-(2'-carboxy-5'-Br-phenylazo)-2-naphthol (H2 L3 ) as ligands is reported. The ligands differ in the substituents at the phenyl ring to probe their influence on the redox behavior, biological activity, and magnetochemistry of the complexes, for which the results are presented and discussed...
May 9, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29659858/zaaps-programme-results-for-2016-an-activity-and-spectrum-analysis-of-linezolid-using-clinical-isolates-from-medical-centres-in-42-countries
#2
Rodrigo E Mendes, Lalitagauri Deshpande, Jennifer M Streit, Helio S Sader, Mariana Castanheira, Patricia A Hogan, Robert K Flamm
Objectives: To report the linezolid activity, resistance mechanisms and epidemiological typing of selected isolates observed during the 2016 Zyvox® Annual Appraisal of Potency and Spectrum (ZAAPS) programme. Methods: A total of 8325 organisms were consecutively collected from 76 centres in 42 countries (excluding the USA). Broth microdilution susceptibility testing was performed and isolates displaying linezolid MICs of ≥4 mg/L were molecularly characterized...
April 6, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29538033/lumbar-osteophyte-avid-on-68ga-prostate-specific-membrane-antigen-pet-ct
#3
Mads Ryø Jochumsen, Michael Alle Madsen, Lise Gammelgaard, Kirsten Bouchelouche
A 75-year-old man with recently diagnosed high-risk prostate cancer was referred for primary staging with Ga-prostate-specific membrane antigen (PSMA) PET/CT. The scan revealed intense Ga-PSMA uptake in a lumbar osteophyte on the right side of level L2/L3, whereas several other spinal osteophytes showed no Ga-PSMA uptake. MRI findings in the L3 vertebra was consistent with a benign Modic type 1 lesion, but MRI showed no signs of malignancy in the osteophyte with high Ga-PMSA uptake. This case presents an osteophyte as an addition to the list of potential benign pitfalls to be aware of when interpreting Ga-PSMA PET/CT...
June 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29525282/characterization-of-the-immune-response-elicited-by-the-vaccinia-virus-l3-protein-delivered-as-naked-dna
#4
Maite Ramírez, Saritza Santos, Osmarie Martínez, Ricardo Rodríguez, Eric Miranda, Willy D Ramos-Perez, Miguel Otero
Poxviruses are complex dsDNA viruses with over 200 genes, many of them with unknown role in the stimulation of immune responses. Among these, the vaccinia virus (VACV) L3L ORF encodes an essential protein for the transcription of the VACV early genes. To the best of our knowledge, the immune response elicited by L3 has not been characterized. In this regard, our data describes a DNA L3-coding plasmid (pL3L) that stimulates both, humoral- and cell-mediated immune responses in a mouse model. Cell-mediated immune responses were measured by IFN-γ and IL-4 ELISPOT assays...
April 5, 2018: Vaccine
https://www.readbyqxmd.com/read/29519320/mechanism-of-action-of-cytotoxic-compounds-from-the-seeds-of-euphorbia-lathyris
#5
Yu-Ning Teng, Yingzi Wang, Pei-Ling Hsu, Guang Xin, Yu Zhang, Susan L Morris-Natschke, Masuo Goto, Kuo-Hsiung Lee
BACKGROUND: The seeds of Euphorbia lathyris are used in traditional Chinese medicines for the treatment of various medical conditions. E. lathyris contains many natural diterpenes with a lathyrane skeleton. PURPOSE AND STUDY DESIGN: Five lathyrane-type diterpenoids named Euphorbia factors L1 , L2 , L3 , L8 , and L9 (1-5), were investigated for cytotoxicity against A549, MDA-MB-231, KB, and MCF-7 cancer cell lines and the KB-VIN multidrug resistant (MDR) cancer cell line...
March 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29499458/synthesis-structural-and-antimicrobial-studies-of-type-ii-topoisomerase-targeted-copper-ii-complexes-of-1-3-disubstituted-thiourea-ligands
#6
Anna Bielenica, Aleksandra Drzewiecka-Antonik, Paweł Rejmak, Joanna Stefańska, Michał Koliński, Sebastian Kmiecik, Bogdan Lesyng, Marta Włodarczyk, Piotr Pietrzyk, Marta Struga
A series of Cu(II) complexes of 3-(trifluoromethyl)phenylthiourea derivatives was synthesized. Their structural properties were investigated by spectroscopic techniques (infrared and electron paramagnetic resonance), as well as molecular modeling. All studied coordination compounds are mononuclear complexes containing two chelating ligands bonded to the metal cation via S and deprotonated N atoms. The new chelates were evaluated for their antimicrobial potency. The complex of 1-(3,4-dichlorophenyl)-3-[3-(trifluoromethyl)phenyl]thiourea (3) presented the highest activity against Gram-positive pathogens, even stronger than the activity of its non-complexed counterpart and the reference drug...
May 2018: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29469988/dorsal-root-ganglia-volume-differentiates-schwannomatosis-and-neurofibromatosis-2
#7
Tim Godel, Victor-Felix Mautner, Said Farschtschi, Mirko Pham, Daniel Schwarz, Moritz Kronlage, Isabel Gugel, Sabine Heiland, Martin Bendszus, Philipp Bäumer
Schwannomatosis and neurofibromatosis type 2 are hereditary tumor syndromes, and peripheral neuropathy has been reported in both. We prospectively applied in vivo morphometric measurement of dorsal root ganglia volume in 16 schwannomatosis patients, 14 neurofibromatosis type 2 patients, and 26 healthy controls by magnetic resonance neurography. Compared to healthy controls, dorsal root ganglia hypertrophy was a consistent finding in neurofibromatosis type 2 (L3, + 267%; L4, + 235%; L5, + 241%; S1, + 300%; S2, + 242%; Bonferroni-adjusted p < 0...
April 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29458065/nosocomial-ventriculitis-caused-by-a-meticillin-and-linezolid-resistant-clone-of-staphylococcus-epidermidis-in-neurosurgical-patients
#8
C Rodríguez-Lucas, J Fernández, J A Boga, L López-Amor, L Forcelledo, E Lázaro-López, M R Rodicio
BACKGROUND: Postneurosurgical ventriculitis is mainly caused by coagulase-negative staphylococci. The rate of linezolid-resistant Staphylococcus epidermidis (LRSE) is increasing worldwide. AIMS: To report clinical, epidemiological and microbiological data from a series of ventriculitis cases caused by LRSE in a Spanish hospital between 2013 and 2016. METHODS: Cases of LRSE ventriculitis were reviewed retrospectively in a Spanish hospital over a four-year period...
February 16, 2018: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29433530/correlation-between-lumbar-intervertebral-disc-height-and-lumbar-spine-sagittal-alignment-among-asymptomatic-asian-young-adults
#9
Feng Zhang, Kai Zhang, Hai-Jun Tian, Ai-Min Wu, Xiao-Fei Cheng, Tang-Jun Zhou, Jie Zhao
BACKGROUND: To investigate the distribution and characteristics of the lumbar intervertebral disc height (IDH) in asymptomatic Asian population and to determine whether the lumbar IDH is related to the lumbar spine sagittal alignment. METHODS: A cohort of 169 cases of asymptomatic volunteers was enrolled from January 2014 to July 2016. All participants underwent magnetic resonance imaging of the lumbar spine and panoramic radiography of the spine. Panoramic radiographs of the spine were taken to evaluate pelvic incidence (PI), sacral slope (SS), and pelvic tilt (PT) using Surgimap® software...
February 12, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29345503/effectiveness-of-the-biophysical-barriers-to-the-peridural-fibrosis-in-rat-laminectomy-model
#10
Ibrahim Akkurt, Bulent Bakar, Gungor Cagdas Dincel, Fatma Azize Budak Yıldıran, Mustafa Ogden, Egemen Nursoy, Elif Sari
PURPOSE: Peridural fibrosis which could occur after the spinal surgery could adhere neural tissue closely and may cause to neural entrapment symptoms and require surgical reintervention. AIM OF THE STUDY: Present study was designed to reduce occurrence of peridural fibrosis in rat laminectomy model by using biophysical barriers called hyaluronic acid (HAS) dural barrier, activated polyethylene glycol and polyethylene imine (PEG) dural barrier, and platelet-rich plasma (PRP)...
January 18, 2018: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/29298564/diffusion-tensor-imaging-of-scarring-necrosis-and-cavitation-based-on-histopathological-findings-in-dogs-with-chronic-spinal-cord-injury-evaluation-of-multiple-diffusion-parameters-and-their-correlations-with-histopathological-findings
#11
Hakyoung Yoon, Won-Jin Moon, Sang-Soep Nahm, Jaehwan Kim, Kidong Eom
The use of diffusion tensor imaging (DTI) for the characterization of various lesion types in dogs with spinal cord injury (SCI) has not been investigated. The aim of this study was to characterize scarring (loose immature scarring [LIMS], intermediate mature scarring [IMS], and dense mature scarring [DMS]), necrosis, cavitation, and acute hemorrhage using multiple DTI parameters and determine the correlations between the DTI parameters and histopathological finding in dogs with controlled SCI. All imaging data were obtained from the lumbar spinal cord (from L1 to L3) of normal and SCI dogs using a 3-Tesla magnetic resonance imaging scanner...
March 29, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29283191/the-clustering-and-morphology-of-chondrocytes-in-normal-and-mildly-degenerate-human-femoral-head-cartilage-studied-by-confocal-laser-scanning-microscopy
#12
Asima Karim, Anish K Amin, Andrew C Hall
Chondrocytes are the major cell type present in hyaline cartilage and they play a crucial role in maintaining the mechanical resilience of the tissue through a balance of the synthesis and breakdown of extracellular matrix macromolecules. Histological assessment of cartilage suggests that articular chondrocytes in situ typically occur singly and demonstrate a rounded/elliptical morphology. However, there are suggestions that their grouping and fine shape is more complex and that these change with cartilage degeneration as occurs in osteoarthritis...
April 2018: Journal of Anatomy
https://www.readbyqxmd.com/read/29282740/use-of-tunisian-flavored-olive-oil-as-anisakicidal-agent-in-industrial-anchovy-marinating-process
#13
Najla Trabelsi, Stefania M Marotta, Filippo Giarratana, Amani Taamali, Mokhtar Zarrouk, Graziella Ziino, Alessandro Giuffrida
BACKGROUND: Natural compounds are more frequently used against Anisakis, responsible for the important fish-borne disease anisakidosis. The aim of the study was to evaluate the effectiveness of enriched Tunisian olive oil with different spices (cumin, turmeric, clove, thyme, and lemon) against Anisakis larvae type 1. RESULTS: In vitro experiment: larvae were submerged separately in the aforementioned oils and then examined to check viability. For each oil, LT50 and LT100 were calculated...
December 28, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29214371/biomechanical-investigation-of-lumbar-hybrid-stabilization-in-two-level-posterior-instrumentation
#14
Aldemar Andres Hegewald, Sebastian Hartmann, Alexander Keiler, Kai Michael Scheufler, Claudius Thomé, Werner Schmoelz
PURPOSE: Hybrid stabilization with a dynamic implant has been suggested to avoid adjacent segment disease by creating a smoother transition zone from the instrumented segments to the untreated levels above. This study aims to characterize the transition zones of two-level posterior instrumentation strategies for elucidating biomechanical differences between rigid fixation and the hybrid stabilization approach with a pedicle screw-based dynamic implant. METHODS: Eight human lumbar spines (L1-5) were loaded in a spine tester with pure moments of 7...
December 6, 2017: European Spine Journal
https://www.readbyqxmd.com/read/29202859/complications-of-lumbar-disc-herniations-following-trans-sacral-epiduroscopic-lumbar-decompression-a-single-center-retrospective-study
#15
Seung-Kook Kim, Su-Chan Lee, Seung-Woo Park, Eun-Sang Kim
BACKGROUND: Trans-sacral epiduroscopic lumbar decompression (SELD) is an emerging procedure for the treatment of lumbar disc herniation (LDH), with favorable outcomes having been reported. However, the complications associated with SELD have not been comprehensively evaluated to date. Therefore, the aim of our study was to describe the incidence rate, types, and characteristics of complications following SELD and management outcomes. METHODS: Retrospective analysis of the surgical and clinical outcomes for 127 patients (average age, 42...
December 4, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29146435/epidemiology-and-management-of-spinal-trauma-in-children-and-adolescents-18-years-old
#16
Asdrubal Falavigna, Orlando Righesso, Pedro Guarise da Silva, Felix Adolfo Sanchez Chavez, Ericson Sfreddo, Leandro Pelegrini de Almeida, Manuel Jose Valencia Carrasco, Andrei Fernandes Joaquim
OBJECTIVE: This retrospective study reports the epidemiology, clinical aspects, and management of spinal trauma in children and adolescents. METHODS: Multicenter study of 215 cases of spinal trauma in individuals <18 years of age. All patients were submitted to preoperative and postoperative radiologic and clinical evaluation. The fractures were classified according to the AOSpine fracture classification. Neurological evaluation was performed using the Frankel scale at admission to hospital and at the last follow-up...
February 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29145287/transforaminal-endoscopy-in-lumbar-burst-fracture-a-case-report
#17
Yuanyi Wang, Cong Ning, Liyu Yao, Xiuying Huang, Chengliang Zhao, Bin Chen, Nan Zhang
RATIONALE: Lumbar burst fractures are frequent injury resulting from high-energy trauma, and the patients suffer from pain and the neurologic dysfunction. Although minimally invasive techniques have advanced rapidly, it was the first time to apply transforaminal endoscopic combined with percutaneous pedicle screw fixation to treatment of lumbar burst fractures. PATIENT CONCERNS: A 33-year-old man underwent Magerl type A3.1 burst fracture at L2 and compression fractures at L3 due to falling from a height with severe lower back pain, sensory loss, and atony of the right leg...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29096153/uptake-and-speciation-of-uranium-in-synthetic-gypsum-caso-4-%C3%A2-2h-2-o-applications-to-radioactive-mine-tailings
#18
Jinru Lin, Wei Sun, Jacques Desmarais, Ning Chen, Renfei Feng, Patrick Zhang, Dien Li, Arthur Lieu, John S Tse, Yuanming Pan
Phosphogypsum formed from the production of phosphoric acid represents by far the biggest accumulation of gypsum-rich wastes in the world and commonly contains elevated radionuclides, including uranium, as well as other heavy metals and metalloids. Therefore, billions-of-tons of phosphogypsum stockpiled worldwide not only possess serious environmental problems but also represent a potential uranium resource. Gypsum is also a major solid constituent in many other types of radioactive mine tailings, which stems from the common usage of sulfuric acid in extraction processes...
January 2018: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/29032017/next-generation-sequencing-technology-a-new-tool-for-killer-cell-immunoglobulin-like-receptor-allele-typing-in-hematopoietic-stem-cell-transplantation
#19
B Maniangou, C Retière, K Gagne
Killer cell Immunoglobulin-like Receptor (KIR) genes are a family of genes located together within the leukocyte receptor cluster on human chromosome 19q13.4. To date, 17 KIR genes have been identified including nine inhibitory genes (2DL1/L2/L3/L4/L5A/L5B, 3DL1/L2/L3), six activating genes (2DS1/S2/S3/S4/S5, 3DS1) and two pseudogenes (2DP1, 3DP1) classified into group A (KIR A) and group B (KIR B) haplotypes. The number and the nature of KIR genes vary between the individuals. In addition, these KIR genes are known to be polymorphic at allelic level (907 alleles described in July 2017)...
February 2018: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
https://www.readbyqxmd.com/read/28938147/development-of-an-experimental-model-of-burst-fracture-with-damage-characterization-of-the-vertebral-bodies-under-dynamic-conditions
#20
A Germaneau, T Vendeuvre, M Saget, P Doumalin, J C Dupré, F Brémand, F Hesser, C Brèque, P Maxy, M Roulaud, O Monlezun, P Rigoard
BACKGROUND: Burst fractures represent a significant proportion of fractures of the thoracolumbar junction. The recent advent of minimally invasive techniques has revolutionized the surgical treatment of this type of fracture. However mechanical behaviour and primary stability offered by these solutions have to be proved from experimental validation tests on cadaveric specimens. Therefore, the aim of this study was to develop an original and reproducible model of burst fracture under dynamic impact...
November 2017: Clinical Biomechanics
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