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https://www.readbyqxmd.com/read/28700441/leiomyoma-with-bizarre-nuclei-clinical-and-pathologic-features-of-30-patients
#1
Mehmet Kefeli, Sultan Caliskan, Emel Kurtoglu, Levent Yildiz, Arif Kokcu
Leiomyoma with bizarre nuclei (LBN) have significant cytologic atypia, but high mitotic rate and tumor cell necrosis are absent. Although it is a benign leiomyoma variant, recurrent cases have been described. In this study, we investigated the clinical and pathologic features of LBN and compared them with related studies. A total of 30 patients diagnosed with LBN in our department were included in this study. In all cases, clinical data (age, complaint, surgery type), macroscopic features (size, location, number of leiomyomas, necrosis, and hemorrhage), microscopic features (bizarre cell distribution, bizarre cell density, cellularity, mitotic rate, tumor margin, necrosis, nuclear pseudoinclusions, karyorrhectic nuclei, prominent eosinophilic nucleoli with perinucleolar clearing, cytoplasmic eosinophilic inclusions, staghorn vessels, and alveolar-type edema), and follow-up data (recurrence and survival period) were evaluated...
July 11, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28685537/effect-of-xianling-gubao-capsules-on-bone-mineral-density-in-osteoporosis-patients
#2
Z H Wu, X Zhu, C K Xu, Y J Chen, L Zhang, C L Zhang
This paper aimed to analyze the clinical effects of Xianling Gubao capsules on the bone mineral density (BMD) of 94 patients with osteoporosis. After reviewing and analyzing the clinical information in our hospital from January 2015 to January 2016, the patients were divided into a control group and a treatment group with 47 cases in each group. Patients in the control group were treated with routine Western medicine, while the treatment group received Xianling Gubao capsules. Both groups were treated continuously for 3 courses (30 days each course) and had their BMD analyzed and compared...
April 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28647183/activity-of-tagetes-minuta-linnaeus-asteraceae-essential-oil-against-l3-anisakis-larvae-type-1
#3
Filippo Giarratana, Daniele Muscolino, Graziella Ziino, Alessandro Giuffrida, Stefania Maria Marotta, Vittorio Lo Presti, Vincenzo Chiofalo, Antonio Panebianco
OBJECTIVE: To evaluate in vitro effects of Tagetes minuta L. essential oil (TEO) on L3 Anisakis larvae type 1. METHODS: In order to evaluate the potential use of Tagetes minuta essential oil against L3 Anisakis larvae three different media were tested: 1) a saline solution (SS); 2) an industrial marinating solution (MS); 3) sunflower seeds oil (SO). For each media and concentrations of TEO (0.1%, 0.5%, 1.0% and 5.0% v/v), 20 parasites were introduced into plastic Petri dishes (diameter 90 mm) and maintained at room temperature...
May 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28644887/sarcopenia-is-a-predictive-factor-for-intestinal-resection-in-admitted-patients-with-crohn-s-disease
#4
Shigeki Bamba, Masaya Sasaki, Azusa Takaoka, Kenichiro Takahashi, Hirotsugu Imaeda, Atsushi Nishida, Osamu Inatomi, Mitsushige Sugimoto, Akira Andoh
The relationship between skeletal muscle volume and the prognosis of patients with inflammatory bowel disease (IBD) remains undetermined. We conducted a retrospective study of 72 IBD patients who were admitted to the hospital due to disease exacerbation. We enrolled IBD patients who had undergone abdominal computed tomography and assessed the nutritional indices, such as the Onodera's prognostic nutritional index (O-PNI) and the controlling nutritional status (CONUT) index. The L3 skeletal muscle index (SMI), which is the ratio of the cross-sectional area of skeletal muscles at the level of the third lumbar (L3) vertebra to the height squared, was used to identify sarcopenia...
2017: PloS One
https://www.readbyqxmd.com/read/28632550/suture-choice-in-lumbar-dural-closure-contributes-to-variation-in-leak-pressures-experimental-model
#5
George M Ghobrial, Christopher M Maulucci, Matthew J Viereck, Sara Beygi, Ameet Chitale, Srinivas Prasad, Jack Jallo, Joshua Heller, Ashwini D Sharan, James S Harrop
STUDY DESIGN: Open-label laboratory investigational study; non-animal surgical simulation. OBJECTIVE: The authors perform a comparison of dural closure strength in a durotomy simulator across 2 different suture materials. SUMMARY OF BACKGROUND DATA: Incidental durotomy leading to persistent cerebrospinal fluid leak adds considerable morbidity to spinal procedures, often complicating routine elective lumbar spinal procedures. Using an experimental durotomy simulation, the authors compare the strength of closure using Gore-Tex with other suture types and sizes, using various closure techniques...
July 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28630201/the-combined-effect-of-the-cfr-methyltransferase-and-ribosomal-protein-l3-mutations-on-resistance-to-ribosome-targeting-antibiotics
#6
Kevin K Pakula, Lykke H Hansen, Birte Vester
Several groups of antibiotics inhibit bacterial growth by binding to bacterial ribosomes. Mutations in the ribosomal protein L3 have been associated with resistance to linezolid and tiamulin, which both bind at the peptidyl transferase center in the ribosome. Resistance to these and other antibiotics also occurs through methylation of 23S ribosomal RNA at position A2503 by the methyltransferase Cfr. The mutations in L3 and the cfr gene have been found together in clinical isolates, raising the question whether they provide a combined effect on antibiotic resistance or growth...
June 19, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28606183/allergenic-activity-of-pseudoterranova-decipiens-nematoda-anisakidae-in-balb-c-mice
#7
Alessandra Ludovisi, Gabriella Di Felice, Noelia Carballeda-Sangiao, Bianca Barletta, Cinzia Butteroni, Silvia Corinti, Gianluca Marucci, Miguel González-Muñoz, Edoardo Pozio, Maria Angeles Gómez-Morales
BACKGROUND: Anisakis simplex is the only fishery-product associated parasite causing clinical allergic responses in humans so far. However, other anisakids, due to the presence of shared or own allergens, could also lead to allergic reactions after sensitization. The aim of this study was to determine if Pseudoterranova decipiens belonging to the family Anisakidae has allergenic activity and is able to induce sensitization after oral administration in a murine (BALB/c mice) model. RESULTS: The ingestion of A...
June 12, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28513169/structural-and-magnetic-properties-of-the-osmium-double-perovskites-ba2-xsrxyoso6
#8
Paula Kayser, Sean Injac, Brendan J Kennedy, Thomas Vogt, Maxim Avdeev, Helen E Maynard-Casely, Zhaoming Zhang
The crystal and magnetic structures of double perovskites of the type Ba2-xSrxYOsO6 were studied by synchrotron X-ray and neutron powder diffraction methods, bulk magnetic susceptibility measurements, and X-ray absorption spectroscopy. The structures were refined using combined neutron and synchrotron data sets based on an ordered array of corner-sharing YO6 and OsO6 octahedra, with the Ba/Sr cations being completely disordered. The structure evolves from cubic to monoclinic Fm3̅m (x ≈ 0.6) → I4/m (x ≈ 1...
May 17, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28418046/novel-nickel-ii-complexes-of-sterically-modified-linear-n4-ligands-effect-of-ligand-stereoelectronic-factors-and-solvent-of-coordination-on-nickel-ii-spin-state-and-catalytic-alkane-hydroxylation
#9
Muniyandi Sankaralingam, Prabha Vadivelu, Mallayan Palaniandavar
A series of Ni(ii) complexes of the types [Ni(L)(CH3CN)2](BPh4)21-3, 5 and [Ni(L4)](BPh4)24, where L = N,N'-bis(2-pyrid-2-ylmethyl)-1,4-diazepane (L1), N-(6-methylpyrid-2-ylmethyl)-N'-(pyrid-2-ylmethyl)-1,4-diazepane (L2), N,N'-bis(6-methyl-2-pyridylmethyl)-1,4-diazepane (L3), N,N'-dimethyl-N,N'-bis(2-pyridylmethyl)ethylenediamine (L5) and L4 = N,N'-bis((1-methyl-1H-imidazole-2-yl)methyl)-1,4-diazepane, have been isolated and characterized. The complex cations of 1 and 4 possess, respectively, distorted octahedral and low-spin square planar coordination geometries in which nickel(ii) is meridionally coordinated to all four nitrogen atoms of L1 and L4...
June 6, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28405646/half-sandwich-iridium-n-heterocyclic-carbene-anticancer-complexes
#10
Chuanlan Wang, Jinfeng Liu, Zhenzhen Tian, Meng Tian, Laijin Tian, Wenqian Zhao, Zhe Liu
Half-sandwich pseudo-octahedral pentamethylcyclopentadienyl Ir(III) complexes of the type [(η(5)-Cp(x))Ir(C^C)Cl]PF6, where Cp(x) is pentamethylcyclopentadienyl (Cp*), or its phenyl (Cp(xph) = C5Me4C6H5) or biphenyl (Cp(xbiph) = C5Me4C6H4C6H5) derivatives, and the C^C-chelating ligands are different N-heterocyclic carbene (NHC) ligands, have been synthesized and characterized. Three X-ray crystal structures have been determined. Except for Cp* complex 1A, the other eleven complexes 1B-4C all showed potent cytotoxicity, with IC50 values ranging from 2...
May 30, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28399545/propionibacterium-acnes-incubation-in-the-discs-can-result-in-time-dependent-modic-changes-a-long-term-rabbit-model
#11
Zhi Shan, Xuyang Zhang, Shengyun Li, Tianming Yu, Junhui Liu, Fengdong Zhao
STUDY DESIGN: A case control study of animal model of Modic changes (MCs) on Rabbits. OBJECTIVE: To evaluate the feasibility of inducing of MCs by injection of Propionibacterium acne (P. acnes) into the lumbar intervertebral discs of rabbits. SUMMARY OF BACKGROUND DATA: MCs have been widely observed, and assume to be closely associated with low back pain and P. acnes, but there are few animal models showing the progression of MCs. METHODS: Ten rabbits were used for the study...
April 10, 2017: Spine
https://www.readbyqxmd.com/read/28323704/minimizing-pedicle-screw-pullout-risks-a-detailed-biomechanical-analysis-of-screw-design-and-placement
#12
Rohan-Jean Bianco, Pierre-Jean Arnoux, Eric Wagnac, Jean-Marc Mac-Thiong, Carl-Éric Aubin
STUDY DESIGN: Detailed biomechanical analysis of the anchorage performance provided by different pedicle screw designs and placement strategies under pullout loading. OBJECTIVE: To biomechanically characterize the specific effects of surgeon-specific pedicle screw design parameters on anchorage performance using a finite element model. SUMMARY OF BACKGROUND DATA: Pedicle screw fixation is commonly used in the treatment of spinal pathologies...
April 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28072800/modified-percutaneous-lumbar-foraminoplasty-and-percutaneous-endoscopic-lumbar-discectomy-instrument-design-technique-notes-and-5-years-follow-up
#13
Zhen-Zhou Li, Shu-Xun Hou, Wei-Lin Shang, Ke-Ran Song, Hong-Liang Zhao
BACKGROUND: Conventional percutaneous endoscopic lumbar discectomy (PELD) with an "inside-outside" technique has 4.3% - 10.3% surgical failure rate, especially in central herniated discs (HDs), migrated HDs, and axillary type HDs. PELD with foraminoplasty has been used for complex HDs. Percutaneous lumbar foraminoplasty (PLF), which is performed with a trephine or bone reamer introduced over a guidewire without a protective working cannula in the original Tessys technique, can quickly cut the hypertrophied bony structure under fluoroscopic guidance, and risk injury to the exiting and traversing nerve roots...
January 2017: Pain Physician
https://www.readbyqxmd.com/read/28040610/the-impact-of-metastasis-on-the-mineral-phase-of-vertebral-bone-tissue
#14
Mikhail Burke, Ayelet Atkins, Alex Kiss, Margarete Akens, Albert Yee, Cari Whyne
The negative impact of metastases on the mechanical performance of vertebral bone is often attributed to reduced bone density and/or compromised architecture. However limited characterization has been done on the impact of metastasis on the mineralization of bone tissue and resulting changes in material behaviour. This study aimed to evaluate the impact of metastasis on micro and nano scale characteristics of the mineral phase of bone, specifically mineral crystal growth, homogeneity of mineralization and changes in intrinsic material properties...
December 23, 2016: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/27771064/a-pasteurella-multocida-strain-affecting-nulliparous-heifers-and-calves-in-different-ways
#15
Conny Turni, Denise Dayao, Gorka Aduriz, Nekane Cortabarria, Carolina Tejero, Jose C Ibabe, Reema Singh, Pat Blackall
Pasteurella multocida isolates from dairy cattle on a farm in Spain were associated with pneumonia of calves (six isolates) and mastitis of heifers (five isolates). The objective was to determine if the P. multocida isolates retrieved from both disease scenarios were the same strain or whether more than one strain was present. The isolates were identified by a species-specific polymerase chain (PCR) assay, serotyped by the Heddleston scheme and then typed by a number of molecular genotyping assays including multi-locus sequence typing (MLST)...
November 15, 2016: Veterinary Microbiology
https://www.readbyqxmd.com/read/27727405/resistance-to-linezolid-in-staphylococcus-spp-clinical-isolates-associated-with-ribosomal-binding-site-modifications-novel-mutation-in-domain-v-of-23s-rrna
#16
Rosario Musumeci, Enrico Calaresu, Jolanda Gerosa, Davide Oggioni, Simone Bramati, Patrizia Morelli, Ida Mura, Andrea Piana, Bianca Maria Are, Clementina Elvezia Cocuzza
Linezolid is the main representative of the oxazolidinones, introduced in 2000 in clinical practice to treat severe Gram-positive infections. This compound inhibits protein synthesis by binding to the peptidyl transferase centre of the 50S bacterial ribosomal subunit. The aim of this study was to characterize 12 clinical strains of linezolid-resistant Staphylococcus spp. isolated in Northern Italy. All isolates of Staphylococcus spp. studied showed a multi-antibiotic resistance phenotype. In particular, all isolates showed the presence of the mecA gene associated with SSCmec types IVa, V or I...
October 2016: New Microbiologica
https://www.readbyqxmd.com/read/27707768/marrow-adipose-tissue-spectrum-in-obesity-and-type-2-diabetes-mellitus
#17
Iana M de Araújo, Carlos E G Salmon, Andressa K Nahas, Marcello H Nogueira-Barbosa, Jorge Elias, Francisco J A de Paula
OBJECTIVE: To assess the association of bone mass and marrow adipose tissue (MAT) with other fat depots, insulin resistance, bone remodeling markers, adipokines and glucose control in type 2 diabetes and obesity. DESIGN AND METHODS: The study groups comprised 24 controls (C), 26 obese (O) and 28 type 2 diabetes. Dual-energy X-ray absorptiometry was used to determine bone mineral density (BMD). Blood samples were collected for biochemical measurements. (1)H Magnetic resonance spectroscopy was used to assess MAT in the L3 vertebra, and abdominal magnetic resonance imaging was used to assess intrahepatic lipids in visceral (VAT) and subcutaneous adipose tissue...
January 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/27649071/classification-of-high-intensity-zones-of-the-lumbar-spine-and-their-association-with-other-spinal-mri-phenotypes-the-wakayama-spine-study
#18
Masatoshi Teraguchi, Dino Samartzis, Hiroshi Hashizume, Hiroshi Yamada, Shigeyuki Muraki, Hiroyuki Oka, Jason Pui Yin Cheung, Ryohei Kagotani, Hiroki Iwahashi, Sakae Tanaka, Hiroshi Kawaguchi, Kozo Nakamura, Toru Akune, Kenneth Man-Chee Cheung, Noriko Yoshimura, Munehito Yoshida
INTRODUCTION: High intensity zones (HIZ) of the lumbar spine are a phenotype of the intervertebral disc noted on MRI whose clinical relevance has been debated. Traditionally, T2-weighted (T2W) magnetic resonance imaging (MRI) has been utilized to identify HIZ of lumbar discs. However, controversy exists with regards to HIZ morphology, topography, and association with other MRI spinal phenotypes. Moreover, classification of HIZ has not been thoroughly defined in the past and the use of additional imaging parameters (e...
2016: PloS One
https://www.readbyqxmd.com/read/27559167/partial-breakdown-of-input-specificity-of-stdp-at-individual-synapses-promotes-new-learning
#19
Maxim Volgushev, Jen-Yung Chen, Vladimir Ilin, Roman Goz, Marina Chistiakova, Maxim Bazhenov
UNLABELLED: Hebbian-type learning rules, which underlie learning and refinement of neuronal connectivity, postulate input specificity of synaptic changes. However, theoretical analyses have long appreciated that additional mechanisms, not restricted to activated synapses, are needed to counteract positive feedback imposed by Hebbian-type rules on synaptic weight changes and to achieve stable operation of learning systems. The biological basis of such mechanisms has remained elusive. Here we show that, in layer 2/3 pyramidal neurons from slices of visual cortex of rats, synaptic changes induced at individual synapses by spike timing-dependent plasticity do not strictly follow the input specificity rule...
August 24, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27543534/a-cadaver-study-comparing-spread-of-dye-and-nerve-involvement-after-three-different-quadratus-lumborum-blocks
#20
L Carline, G A McLeod, C Lamb
BACKGROUND: Posterior variants of abdominal wall block include the quadratus lumborum type I, quadratus lumborum type II and quadratus lumborum transmuscular blocks. Our objectives were to compare the spread of injectate and nerve involvement, after conducting blocks using ultrasound guidance in soft embalmed cadavers. METHODS: After randomization, an experienced anaesthetist conducted three quadratus lumborum 1, three quadratus lumborum 2 and four transmuscular blocks on the left or right sides of five cadavers...
September 2016: British Journal of Anaesthesia
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