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https://www.readbyqxmd.com/read/27914496/computed-tomography-derived-skeletal-muscle-index-a-novel-predictor-of-frailty-and-hospital-length-of-stay-after-transcatheter-aortic-valve-replacement
#1
Vishal Dahya, Jingjie Xiao, Carla M Prado, Penny Burroughs, Dan McGee, Aline C Silva, Julian E Hurt, Shafi G Mohamed, Thomas Noel, Wayne Batchelor
: To determine the prevalence of low skeletal muscle mass in patients undergoing transcatheter aortic valve replacement (TAVR) and whether skeletal muscle mass measured from preoperative computed tomography (CT) images provides value in predicting postoperative length of stay (LOS). BACKGROUND: There are limited data on the use of body composition as a frailty measure in TAVR patients and no studies have determined if this measure predicts LOS. METHODS: We studied 104 consecutive patients who underwent TAVR at Tallahassee Memorial Hospital from 2012 to 2016...
December 2016: American Heart Journal
https://www.readbyqxmd.com/read/27905508/tissue-loading-created-during-spinal-manipulation-in-comparison-to-loading-created-by-passive-spinal-movements
#2
Martha Funabashi, Gregory N Kawchuk, Albert H Vette, Peter Goldsmith, Narasimha Prasad
Spinal manipulative therapy (SMT) creates health benefits for some while for others, no benefit or even adverse events. Understanding these differential responses is important to optimize patient care and safety. Toward this, characterizing how loads created by SMT relate to those created by typical motions is fundamental. Using robotic testing, it is now possible to make these comparisons to determine if SMT generates unique loading scenarios. In 12 porcine cadavers, SMT and passive motions were applied to the L3/L4 segment and the resulting kinematics tracked...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27879506/fatty-degeneration-of-the-paraspinal-muscle-in-patients-with-degenerative-lumbar-kyphosis-a-new-evaluation-method-of-quantitative-digital-analysis-using-mri-and-ct-scan
#3
Seung-Jae Hyun, Chae-Wan Bae, Sang-Hoon Lee, Seung-Chul Rhim
STUDY DESIGN: A comparative case-control study. OBJECTIVE: The aim of this study was to quantify the degree of paraspinal muscle changes in degenerative lumbar kyphosis (DLK) patients using magnetic resonance imaging and computed tomography scanning. SUMMARY OF BACKGROUND DATA: Although the pathophysiology of DLK is not completely understood, extensive degeneration and weakness of the lumbar extensor muscles are thought to underlie the condition in most patients...
December 2016: Clinical Spine Surgery
https://www.readbyqxmd.com/read/27878398/hsp90-is-a-promising-target-in-gemcitabine-and-5-fluorouracil-resistant-pancreatic-cancer
#4
Tarik Ghadban, Judith L Dibbern, Matthias Reeh, Jameel T Miro, Tung Y Tsui, Ulrich Wellner, Jakob R Izbicki, Cenap Güngör, Yogesh K Vashist
Chemotherapy (CT) options in pancreatic cancer (PC) are limited to gemcitabine and 5-fluorouracil (5-FU). Several identified molecular targets in PC represent client proteins of HSP90. HSP90 is a promising target since it interferes with many oncogenic signaling pathways simultaneously. The aim of this study was to evaluate the efficacy of different HSP90 inhibitors in gemcitabine and 5-FU resistant PC. PC cell lines 5061, 5072 and 5156 were isolated and brought in to culture from patients being operated at our institution...
November 22, 2016: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/27876503/cranio-caudal-asymmetries-in-trabecular-architecture-reflect-vertebral-fracture-patterns
#5
Ge Yang, Michele C Battié, Steven K Boyd, Tapio Videman, Yue Wang
Clinically, vertebral fractures often occur in the upper lumbar spine and involve the superior endplate of a vertebra (which is immediately caudal to a disc). Knowledge that the cranial endplate of a disc is thicker and has greater bone mineral density (BMD) than the corresponding caudal endplate helps to explain this phenomenon. In this study, we investigated structural differences in vertebral trabeculae on either side of a lumbar disc to provide further insight into vertebral fracture risk. As the focus is trabecular difference within a spinal motion segment, we define cranial and caudal vertebral trabeculae relative to the disc...
November 19, 2016: Bone
https://www.readbyqxmd.com/read/27872724/are-magnetic-resonance-imaging-or-radiographic-findings-correlated-with-clinical-prognosis-in-spinal-cord-neuropathy
#6
Fatemeh Neshat Halati, Alireza Vajhi, Mohammad Molazem, Mohammad Mehdi Dehghan, Fereshteh Ansari
Dogs presented to the Small Animal Hospital of Veterinary Medicine, University of Tehran were included in the present study if spinal or intervertebral disc involvement was suspected. Clinical signs were recorded as well as general information of the patient such as age, breed and sex. Sixty dogs were examined radiographically and two standard orthogonal lateral and ventrodorsal projections were taken from the suspected region. Then magnetic resonance imaging (MRI) was performed for all patients. Agreement between MRI and radiographic findings, comparison of sex and breed with diagnostic imaging grades, comparison between diagnostic imaging grades and mean age, recovery rate after surgery or medical treatment, effects of diagnostic imaging severity grades on surgical or medical referrals were evaluated statistically...
2016: Veterinary Research Forum
https://www.readbyqxmd.com/read/27865985/cfr-mediated-linezolid-resistant-clinical-isolates-of-methicillin-resistant-coagulase-negative-staphylococci-from-china
#7
Yunjia Song, Yuan Lv, Lanqing Cui, Yun Li, Qian Ke, Yixuan Zhao
Three linezolid-resistant coagulase-negative staphylococci (LR-CoNS), including two Staphylococcus cohnii and one Staphylococcus capitis, were isolated from 1104 clinical staphylococcal isolates across China in 2013-2014. Antibiotic susceptibilities of the bacteria were determined by the agar dilution method. PCR and DNA sequencing were performed to determine the potential molecular mechanism of linezolid resistance. The two linezolid-resistant S. cohnii isolates were subjected to pulsed-field gel electrophoresis (PFGE) to investigate their genetic relatedness...
November 5, 2016: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/27865369/feasibility-of-using-head-and-neck-ct-imaging-to-assess-skeletal-muscle-mass-in-head-and-neck-cancer-patients
#8
Justin E Swartz, Ajit J Pothen, Inge Wegner, Ernst J Smid, Karin M A Swart, Remco de Bree, Loek P H Leenen, Wilko Grolman
OBJECTIVES: Patients with head and neck cancer (HNC) have a higher risk of malnutrition and sarcopenia, which is associated with adverse clinical outcome. As abdominal CT-imaging is often used to detect sarcopenia, such scans are rarely available in HNC patients, possibly explaining why no studies investigate the effect of sarcopenia in this population. We correlated skeletal muscle mass assessed on head and neck CT-scans with abdominal CT-imaging. METHODS: Head and neck, and abdominal CT-scans of trauma (n=51) and HNC-patients (n=52) were retrospectively analyzed...
November 2016: Oral Oncology
https://www.readbyqxmd.com/read/27862981/standardization-of-sample-homogenization-for-mosquito-identification-using-an-innovative-proteomic-tool-based-on-protein-profiling
#9
Amira Nebbak, Alexandra C Willcox, Idir Bitam, Didier Raoult, Philippe Parola, Lionel Almeras
The rapid spread of vector-borne diseases demands the development of an innovative strategy for arthropod monitoring. The emergence of MALDI-TOF MS as a rapid, low-cost and accurate tool for arthropod identification is revolutionizing medical entomology. However, as MS spectra from an arthropod can vary according to the body part selected, the sample homogenization method used and the mode and duration of sample storage, standardization of protocols is indispensable prior to the creation and sharing of an MS reference spectra database...
November 12, 2016: Proteomics
https://www.readbyqxmd.com/read/27862349/lymphogranuloma-venereum-with-only-proximal-rectal-involvement-mimicking-inflammatory-bowel-disease-a-potential-diagnostic-pitfall
#10
F Rob, J Kašpírková, K Jůzlová, M Pešta, J Hercogová
Lymphogranuloma venereum (LGV) is a sexually transmitted infection (STI) caused by the invasive serovars L1, L2 and L3 of Chlamydia trachomatis (C. trachomatis). [1] The incidence of LGV is rising in many Western countries. [2] The most common symptoms of LGV are proctitis and inguinal lymphadenopathy. LGV mimicking inflammatory bowel disease (IBD) is not a rare condition and has already been described in several reports. [3,4] LGV can affect even more proximal parts of the bowel. [5] Diagnosis of LGV is usually done by positive NAAT for C...
November 15, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27858380/effect-of-etanercept-on-the-formation-of-epidural-fibrosis-in-an-experimental-model
#11
Zahir Kizilay, Nesibe Kahraman Çetin, Abdullah Topcu, Özgür Ismailoğlu, İmran Kurt Ömürlü, Serdar Aktaş, Ali Yilmaz
AIM: To investigate the effects of local and systemic administration of etanercept on the formation of epidural fibrosis. MATERIAL AND METHODS: Twenty-eight rats were randomly divided into four equal groups (control, Spongostan, local etanercept and systemic etanercept) and laminectomy was performed between T11 and L1 in all rats. Spongostan was soaked with saline (0.1 mg/kg), local etanercept (300 µg/kg) was applied with Spongostan and systemic etanercept (300 µg/kg/week) was applied subcutaneously...
October 17, 2016: Turkish Neurosurgery
https://www.readbyqxmd.com/read/27858312/isolation-and-complete-genome-characterization-of-novel-reassortant-orthoreovirus-from-common-vole-microtus-arvalis
#12
Enikő Fehér, Gábor Kemenesi, Miklós Oldal, Kornélia Kurucz, Renáta Kugler, Szilvia L Farkas, Szilvia Marton, Győző Horváth, Krisztián Bányai, Ferenc Jakab
A novel mammalian orthoreovirus (MRV) strain was isolated from the lung tissue of a common vole (Microtus arvalis) with Tula hantavirus infection. Seven segments (L1-L3, M2-M3, S2, and S4) of the Hungarian MRV isolate MORV/47Ma/06 revealed a high similarity with an MRV strain detected in bank vole (Myodes glareolus) in Germany. The M1 and S3 segment of the Hungarian isolate showed the closest relationship with the sequence of a Slovenian human and a French murine isolate, respectively. The highest nucleotide and amino acid identity values were above 90 and 95% in all of the comparisons to the reference sequences in GenBank, except for the S1 with a maximum of 69...
November 17, 2016: Virus Genes
https://www.readbyqxmd.com/read/27858238/instrumentation-failure-following-pedicle-subtraction-osteotomy-the-role-of-rod-material-diameter-and-multi-rod-constructs
#13
Andrea Luca, Claudia Ottardi, Maurizio Sasso, Liliana Prosdocimo, Luigi La Barbera, Marco Brayda-Bruno, Fabio Galbusera, Tomaso Villa
PURPOSE: Pedicle subtraction osteotomy (PSO) has a complication rate noticeably higher than other corrective surgical techniques used for the treatment of spinal sagittal imbalance. In particular, rod breakage and pseudoarthrosis remain burning issues of this technique. Goal of this study was to investigate the biomechanical performance of several hardware constructs. METHODS: The study was performed using two validated finite element models of the lumbosacral spine (L1-S1) incorporating a PSO on L3 and L4, respectively...
November 17, 2016: European Spine Journal
https://www.readbyqxmd.com/read/27852382/-effect-comparison-of-ultrasound-guided-lower-extremity-nerve-block-and-spinal-anesthesia-in-ankle-surgery
#14
L L Yang, J S Ji, Z W Zhao, W Wang, S Luo, Y C Mo, J L Wang
Objective: To compare the anesthesia effect between ultrasound-guided lower extremity nerve block and spinal anesthesia in ankle surgery. Methods: Upon the approval of institutional Ethics Committee and informed consent, 80 patients American Society of Anesthesiology (ASA)Ⅰ-Ⅱaged 18-70 yr, undergoing ankle surgery from December 2014 to May 2015 in the Fifth Affiliated Hospital of Wen Zhou Medical College, were randomly divided by random numbers into two groups (n=40): nerve block group (group N) and spinal anesthesia (group S)...
November 8, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27848124/reversible-cerebral-vasoconstriction-syndrome-and-posterior-reversible-encephalopathy-syndrome-associated-with-intracranial-hypotension
#15
Katharina Feil, Robert Forbrig, Franziska S Thaler, Julian Conrad, Suzette Heck, Franziska Dorn, Hans-Walter Pfister, Andreas Straube
BACKGROUND: Reversible cerebral vasoconstriction syndrome (RCVS) and posterior reversible encephalopathy syndrome (PRES) are both rare disorders. The pathophysiology of both diseases is not yet fully understood. METHODS: We report the unique case of a 19-year-old comatose woman who was brought to the ER after a series of generalized tonic-clonic seizures 6 days post peridural anesthesia for cesarean section. Vital signs and initial laboratory testing including urine analysis and drug screening were unremarkable...
November 15, 2016: Neurocritical Care
https://www.readbyqxmd.com/read/27835769/efficacy-of-ivermectin-against-gastrointestinal-nematodes-of-cattle-in-denmark-evaluated-by-different-methods-for-analysis-of-faecal-egg-count-reduction
#16
Miguel Peña-Espinoza, Stig M Thamsborg, Matthew J Denwood, Markus Drag, Tina V Hansen, Vibeke F Jensen, Heidi L Enemark
The efficacy of ivermectin (IVM) against gastrointestinal nematodes in Danish cattle was assessed by faecal egg count reduction test (FECRT). Six cattle farms with history of clinical parasitism and avermectin use were included. On the day of treatment (Day 0), 20 naturally infected calves per farm (total n = 120) were stratified by initial faecal egg counts (FEC) and randomly allocated to a treatment group dosed with 0.2 mg IVM kg(-1) body weight s.c. (IVM; n = 10) or an untreated control group (CTL; n = 10)...
October 13, 2016: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/27833845/drosophila-ataxin-2-gene-encodes-two-differentially-expressed-isoforms-and-its-function-in-larval-fat-body-is-crucial-for-development-of-peripheral-tissues
#17
Murilo Carlos Bizam Vianna, Deise Cristina Poleto, Paula Fernanda Gomes, Valéria Valente, Maria Luisa Paçó-Larson
Different isoforms of ataxin-2 are predicted in Drosophila and may underlie different cellular processes. Here, we validated the isoforms B and C of Drosophila ataxin-2 locus (dAtx2), which we found to be expressed in various tissues and at different levels during development. dAtx2-B mRNA was detected at low amounts during all developmental stages, whereas dAtx2-C mRNA levels increase by eightfold from L3 to pupal-adult stages. Higher amounts of dAtx2-B protein were detected in embryos, while dAtx2-C protein was also expressed in higher levels in pupal-adult stages, indicating post-transcriptional control for isoform B and transcription induction for isoform C, respectively...
November 2016: FEBS Open Bio
https://www.readbyqxmd.com/read/27831966/the-kinematics-and-spondylosis-of-the-lumbar-spine-vary-depending-on-the-levels-of-motion-segments-in-individuals-with-low-back-pain
#18
Bryce A Basques, Alejandro A Espinoza Orías, Grant D Shifflett, Michael P Fice, Gunnar B Andersson, Howard S An, Nozomu Inoue
STUDY DESIGN: Prospective cohort study. OBJECTIVE: To identify associations of spondylotic and kinematic changes with low back pain (LBP). SUMMARY OF BACKGROUND DATA: The ability to characterize and differentiate the biomechanics of both the symptomatic and asymptomatic lumbar spine is crucial to alleviate the sparse literature on the association of lumbar spine biomechanics and LBP. METHODS: Lumbar dynamic plain radiographs (flexion-extension), dynamic CT scanning (axial rotation, disc height) and MRI (disc and facet degeneration grades) were obtained for each subject...
November 9, 2016: Spine
https://www.readbyqxmd.com/read/27822593/primary-extramedullary-spinal-germinoma-case-report-and-review-of-the-literature
#19
Qiang Hu, Wenhua Yu, Quan Du, Qiang Zhu, Zhihao Che
The authors describe a case of a purely primary extramedullary spinal germinoma in a young Chinese male. Primary spinal germinoma is extremely rare tumor. Currently, less than 30 histologically verified spinal germinoma cases have been reported previously, mostly involving Asian of Japanese descent. This 24-year-old male suffered from progressive low back pain radiating to both legs. Magnetic resonance imaging showed a well-demarcated, intradural extramedullary mass at the level of L2 and L3. The lesion was totally removed and was confirmed as a germinoma...
November 7, 2016: Neurosurgical Review
https://www.readbyqxmd.com/read/27816644/new-cobalt-ii-and-nickel-ii-complexes-of-benzyl-carbazate-schiff-bases-syntheses-crystal-structures-in-vitro-dna-and-hsa-binding-studies
#20
Palanivelu Nithya, Sannasi Helena, Jim Simpson, Malaichamy Ilanchelian, Aathi Muthusankar, Subbiah Govindarajan
In the present study, new Schiff base complexes with the composition [M(NCS)2(L1)2]·nH2O, where M=Co (n=0) (1) and Ni (n=2) (2); [M(NCS)2(L2)2], M=Co (3) and Ni (4) as well as [M(NCS)2(L3)2], M=Co (5) and Ni (6); (L1=benzyl 2-(propan-2-ylidene)hydrazinecarboxylate, L2=benzyl 2-(butan-2-ylidene)hydrazinecarboxylate and L3=benzyl 2-(pentan-3-ylidene)hydrazinecarboxylate) have been synthesized by a template method. The complexes were characterised by analytical methods, spectroscopic studies, thermal and X-ray diffraction techniques...
October 24, 2016: Journal of Photochemistry and Photobiology. B, Biology
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