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https://www.readbyqxmd.com/read/28632550/suture-choice-in-lumbar-dural-closure-contributes-to-variation-in-leak-pressures-experimental-model
#1
George M Ghobrial, Christopher M Maulucci, Matthew J Viereck, Sara Beygi, Ameet Chitale, Srinivas Prasad, Jack Jallo, Joshua Heller, Ashwini D Sharan, James S Harrop
STUDY DESIGN: Open-label laboratory investigational study; non-animal surgical simulation. OBJECTIVE: The authors perform a comparison of dural closure strength in a durotomy simulator across 2 different suture materials. SUMMARY OF BACKGROUND DATA: Incidental durotomy leading to persistent cerebrospinal fluid leak adds considerable morbidity to spinal procedures, often complicating routine elective lumbar spinal procedures. Using an experimental durotomy simulation, the authors compare the strength of closure using Gore-Tex with other suture types and sizes, using various closure techniques...
July 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28632549/biomechanical-investigation-of-a-novel-revision-device-in-an-osteoporotic-model-pullout-strength-of-pedicle-screw-anchor-versus-larger-screw-diameter
#2
Jacinto Manon, Mir M Hussain, Jonathan Harris, Mark Moldavsky, Frank La Marca, Brandon S Bucklen
STUDY DESIGN: In vitro cadaveric biomechanical study. OBJECTIVE: To assess revision pullout strength of novel anchored screws (AS) versus conventional larger diameter traditional pedicle screws (TPS) in an osteoporotic model. SUMMARY OF BACKGROUND DATA: Pedicle screws are the most ubiquitous method of treating spinal pathologies requiring lumbar fusion. Although these screws are effective in providing 3-column stabilization of the spine, revision surgeries are occasionally necessary, particularly for geriatric and osteoporotic populations...
July 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28630201/the-combined-effect-of-the-cfr-methyltransferase-and-ribosomal-protein-l3-mutations-on-resistance-to-ribosome-targeting-antibiotics
#3
Kevin K Pakula, Lykke H Hansen, Birte Vester
Several groups of antibiotics inhibit bacterial growth by binding to bacterial ribosomes. Mutations in the ribosomal protein L3 have been associated with resistance to linezolid and tiamulin, which both bind at the peptidyl transferase center in the ribosome. Resistance to these and other antibiotics also occurs through methylation of 23S ribosomal RNA at position A2503 by the methyltransferase Cfr. The mutations in L3 and the cfr gene have been found together in clinical isolates, raising the question whether they provide a combined effect on antibiotic resistance or growth...
June 19, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28621776/tuning-pt-and-cu-sites-population-inside-functionalized-uio-67-mof-by-controlling-activation-conditions
#4
L Braglia, E Borfecchia, K A Lomachenko, A L Bugaev, A A Guda, A V Soldatov, B T L Bleken, S Øien-Ødegaard, U Olsbye, K P Lillerud, S Bordiga, G Agostini, M Manzoli, C Lamberti
The exceptional thermal and chemical stability of the UiO-66, -67 and -68 classes of isostructural MOFs [J. Am. Chem. Soc., 2008, 130, 13850] makes them ideal materials for functionalization purposes aimed at introducing active centres for potential application in heterogeneous catalysis. We previously demonstrated that a small fraction (up to 10%) of the linkers in the UiO-67 MOF can be replaced by bipyridine-dicarboxylate (bpydc) moieties exhibiting metal-chelating ability and enabling the grafting of Pt(ii) and Pt(iv) ions in the MOF framework [Chem...
June 16, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/28614233/discordant-lumbar-epidural-hematoma-after-caudal-steroid-injection-a-case-report-care-compliant
#5
Jung Ju Choi, Young Jin Chang, Wol Seon Jung, Kyung Cheon Lee, Ju Ho Kim, Youn Yi Jo
RATIONALE: Caudal epidural injection is one of the conventional treatments of chronic back pain. Even though spinal epidural hematoma after caudal epidural injection is rare but it can cause serious neurologic complication. PATIENT CONCERNS: An 83-year-old woman taking cilostazol received caudal epidural steroid injection because of her chronic back pain. Six hours later, she experienced an acute hip pain which worsened with time. DIAGNOSIS: Magnetic resonance image showed acute cord compression due to a spinal epidural hematoma at L2-S1 level with concomitant central canal compromise at L2/3, L3/4 level...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28609385/association-between-menopause-and-lumbar-disc-degeneration-an-mri-study-of-1-566-women-and-1-382-men
#6
Chao Lou, Hongliang Chen, Liangwei Mei, Weiyang Yu, Kejun Zhu, Feijun Liu, Zhenzhong Chen, Guangheng Xiang, Minjiang Chen, Qiaoyou Weng, Dengwei He
OBJECTIVE: The aim of this study was to revisit and further investigate the association between menopause and disc degeneration in the lumbar spine using a magnetic resonance imaging-based eight-level grading system. METHODS: This study cohort comprised of 1,566 women and 1,382 age-matched men who were admitted for low back pain from June 2013 to October 2016. Data on age, weight, height, body mass index, age at natural menopause, and years since menopause (YSM) were obtained...
June 12, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28606183/allergenic-activity-of-pseudoterranova-decipiens-nematoda-anisakidae-in-balb-c-mice
#7
Alessandra Ludovisi, Gabriella Di Felice, Noelia Carballeda-Sangiao, Bianca Barletta, Cinzia Butteroni, Silvia Corinti, Gianluca Marucci, Miguel González-Muñoz, Edoardo Pozio, Maria Angeles Gómez-Morales
BACKGROUND: Anisakis simplex is the only fishery-product associated parasite causing clinical allergic responses in humans so far. However, other anisakids, due to the presence of shared or own allergens, could also lead to allergic reactions after sensitization. The aim of this study was to determine if Pseudoterranova decipiens belonging to the family Anisakidae has allergenic activity and is able to induce sensitization after oral administration in a murine (BALB/c mice) model. RESULTS: The ingestion of A...
June 12, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28585998/correlation-of-the-features-of-the-lumbar-multifidus-muscle-with-facet-joint-osteoarthritis
#8
Bo Yu, Kaibiao Jiang, Xinfeng Li, Jidong Zhang, Zude Liu
Facet joint osteoarthritis is considered a consequence of the aging process; however, there is evidence that it may be associated with degenerative changes of other structures. The goal of this study was to investigate the correlation between lumbar multifidus muscle features and facet joint osteoarthritis. This retrospective study included 160 patients who had acute or chronic low back pain and were diagnosed with facet joint osteoarthritis on computed tomography scan. Morphometric parameters, including cross-sectional area, muscle-fat index, and percentage of bilateral multifidus asymmetry at L3-L4, L4-L5, and L5-S1, were evaluated with T2-weighted magnetic resonance imaging...
June 6, 2017: Orthopedics
https://www.readbyqxmd.com/read/28584149/different-resistance-mechanisms-for-cadazolid-and-linezolid-in-c-difficile-found-by-whole-genome-sequencing-analysis
#9
Patrick Caspers, Hans H Locher, Philippe Pfaff, Sarah Diggelmann, Georg Rueedi, Daniel Bur, Daniel Ritz
Cadazolid (CDZ) is a new antibiotic currently in clinical development for the treatment of Clostridium difficile infections. CDZ interferes with the bacterial protein synthesis machinery. The aim of the present study was to identify resistance mechanisms for CDZ and compare to linezolid (LZD) in C. difficile by whole genome sequencing (WGS) of strains generated by invitro passages and of LZD resistant clinical isolates. Clones of C. difficile 630 selected with CDZ during 46 passages had a maximally 4-fold increased CDZ MIC, while the LZD MIC of clones selected with LZD increased up to 16-fold...
June 5, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28579287/effect-of-1-or-2-level-posterior-lumbar-interbody-fusion-on-global-sagittal-balance
#10
Jae Hwan Cho, Youn-Suk Joo, Cheongsu Lim, Chang Ju Hwang, Dong-Ho Lee, Choon Sung Lee
BACKGROUND CONTEXT: Sagittal imbalance is associated with poor clinical outcomes in patients with degenerative lumbar disease. However, there is no consensus on the impact of posterior lumbar interbody fusion (PLIF) on local and global sagittal balance. PURPOSE: To reveal the effect of 1- or 2-level PLIF on global sagittal balance. STUDY DESIGN/SETTING: A retrospective case-control study. PATIENTS SAMPLE: This study included 88 patients who underwent a 1- or 2-level PLIF for spinal stenosis with spondylolisthesis...
June 1, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28577539/inguinal-and-anorectal-lymphogranuloma-venereum-a-case-series-from-a-sexually-transmitted-disease-center-in-rome-italy
#11
Alessandra Latini, Mauro Zaccarelli, Maria Grazia Paglia, Maria Gabriella Donà, Amalia Giglio, Domenico Moretto, Antonella Vulcano, Massimo Giuliani, Manuela Colafigli, Marina Ambrifi, Fulvia Pimpinelli, Antonio Cristaudo
BACKGROUND: Lymphogranuloma venereum (LGV) is a sexually transmitted infection caused by L1, L2, L3 serovars of C. trachomatis (CT). Since 2003, LGV cases have been increasing in Europe. Aim of this report is to describe the LGV cases diagnosed in the largest STI center in Rome, Italy, from 2000 to 2016. This report shows that two clinically and epidemiologically different series of cases exist, and that, at present, the ano-rectal LGV represents the clinical variant occurring more frequently among men having sex with men (MSM), particularly those HIV-infected...
June 2, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28547574/effect-of-oxy133-an-osteogenic-oxysterol-on-new-bone-formation-in-rat-two-level-posterolateral-fusion-model
#12
Zorica Buser, Susan Drapeau, Frank Stappenbeck, Renata C Pereira, Farhad Parhami, Jeffrey C Wang
PURPOSE: The aim of our study was to determine the effect of Oxy133 and rhBMP2 on fusion rates and new bone formation in a rat posterolateral fusion (PLF) model. Furthermore, we examined whether Oxy133 could inhibit the adipogenesis that is often present in rhBMP2-induced fusions. METHODS: Sixty-four male Lewis rats underwent two levels PLF (L3-L5). All animals were randomly divided into eight groups based on the test compound that they received: control (DMSO), low-dose rhBMP2 (0...
May 25, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28538596/acute-and-hyper-acute-thoracolumbar-corpectomy-for-traumatic-burst-fractures-using-a-mini-open-lateral-approach
#13
William D Smith, Nick Ghazarian, Ginger Christian
STUDY DESIGN: Retrospective chart review. OBJECTIVE: The study purpose was to examine the feasibility of acute (<24 hours) and hyper-acute (<8 hours) treatment of thoracolumbar burst fractures to maintain or improve spinal injury scores. SUMMARY OF BACKGROUND DATA: Historically, treatment of spinal burst fractures within 24 hours from injury was considered an "acute" treatment timeframe. Patient polytrauma triage, multiple surgical specialty and hospital resource coordination affect time to treatment...
May 22, 2017: Spine
https://www.readbyqxmd.com/read/28531567/impact-of-body-composition-parameters-on-clinical-outcomes-in-patients-with-metastatic-castrate-resistant-prostate-cancer-treated-with-docetaxel
#14
Samantha J Cushen, Derek G Power, Kevin P Murphy, Ray McDermott, Brendan T Griffin, Marvin Lim, Louise Daly, Peter MacEneaney, Kathleen O' Sullivan, Carla M Prado, Aoife M Ryan
BACKGROUND: Body composition may influence clinical outcomes of certain chemotherapeutic agents. We examined the prognostic significance of skeletal muscle mass and adipose tissue on docetaxel toxicity and overall survival in patients with metastatic castrate resistant prostate cancer (mCRPC). METHODS: A retrospective review of patients medical records with mCRPC, treated with docetaxel was conducted. Body composition parameters (skeletal muscle mass, muscle attenuation [MA], visceral and subcutaneous adipose tissue) were measured at L3 by computed tomography (CT) and defined using previously established cut points...
June 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28513169/structural-and-magnetic-properties-of-the-osmium-double-perovskites-ba2-xsrxyoso6
#15
Paula Kayser, Sean Injac, Brendan J Kennedy, Thomas Vogt, Maxim Avdeev, Helen E Maynard-Casely, Zhaoming Zhang
The crystal and magnetic structures of double perovskites of the type Ba2-xSrxYOsO6 were studied by synchrotron X-ray and neutron powder diffraction methods, bulk magnetic susceptibility measurements, and X-ray absorption spectroscopy. The structures were refined using combined neutron and synchrotron data sets based on an ordered array of corner-sharing YO6 and OsO6 octahedra, with the Ba/Sr cations being completely disordered. The structure evolves from cubic to monoclinic Fm3̅m (x ≈ 0.6) → I4/m (x ≈ 1...
May 17, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28509432/feasibility-assessment-of-shear-wave-elastography-to-lumbar-back-muscles-a-radioanatomic-study
#16
Maud Creze, Krystel Nyangoh Timoh, Olivier Gagey, Laurence Rocher, Marie-France Bellin, Marc Soubeyrand
INTRODUCTION: Low back pain is often associated with tensional changes in the paraspinal muscles detected by palpatory procedures. Shear wave elastography (SWE), recently introduced, allows the stiffness of muscles to be assessed non-invasively. The aim of our work was to study the feasibility of using SWE on the three main lumbar back muscles (multifidus, longissimus and iliocostalis) in vivo after analyzing their muscular architecture ex vivo. MATERIALS AND METHODS: We determined the orientation of fibers in the multifidus, longissimus and iliocotalis muscles in seven fresh cadavers using gross anatomy and B-Mode ultrasound imaging...
May 16, 2017: Clinical Anatomy
https://www.readbyqxmd.com/read/28486758/stimulation-of-the-l2-l3-dorsal-root-ganglia-induces-effective-pain-relief-in-the-low-back
#17
Frank Huygen, Liong Liem, William Cusack, Jeffery Kramer
INTRODUCTION: Chronic low back pain affects millions of people worldwide and can arise through a variety of clinical origins. In the case of Failed Back Surgery Syndrome (FBSS), previous surgical procedures can contribute to low back pain that is often unresponsive to intervention. Although spinal cord stimulation can be an effective treatment modality, it does not provide sufficient pain relief for some intractable cases. Recently, alternative neuromodulation options have been developed, including dorsal root ganglion (DRG) stimulation...
May 9, 2017: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/28473815/gel-based-purification-and-biochemical-study-of-laccase-isozymes-from-ganoderma-sp-and-its-role-in-enhanced-cotton-callogenesis
#18
Amit Kumar, Deepti Singh, Krishna K Sharma, Sakshi Arora, Amarjeet K Singh, Sarvajeet S Gill, Barkha Singhal
Basidiomycetous fungi, Ganoderma lucidum MDU-7 and Ganoderma sp. kk-02 secreted multiple laccase isozymes under diverse growth condition. Aromatic compounds and metal salts were also found to regulate the differential expression of laccase isozymes from both the Ganoderma sp. Laccase isozymes induced in the presence of copper from G. lucidum MDU-7 were purified by gel-based (native-PAGE) purification method. The purity of laccase isozymes was checked by zymogram and SDS-PAGE. The SDS-PAGE of purified proteins confirmed the multimeric nature of laccase isozymes...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28463613/against-the-odds-what-to-expect-in-rehabilitation-of-chronic-spinal-cord-injury-with-a-neurologically-controlled-hybrid-assistive-limb-exoskeleton-a-subgroup-analysis-of-55-patients-according-to-age-and-lesion-level
#19
Dennis Grasmücke, Amrei Zieriacks, Oliver Jansen, Christian Fisahn, Matthias Sczesny-Kaiser, Martin Wessling, Renate C Meindl, Thomas A Schildhauer, Mirko Aach
Objective Age and lesion level are believed to represent outcome predictors in rehabilitation of patients with chronic spinal cord injury (SCI). The Hybrid Assistive Limb (HAL) exoskeleton enables patients to perform a voluntary controlled gait pattern via an electromyography-triggered neuromuscular feedback system, and has been introduced as a temporary gait training tool in patients with SCI. The aim of this prospective pre- and postintervention study was to examine functional outcomes as a function of age and lesion level in patients with chronic incomplete SCI (iSCI) or chronic complete SCI (cSCI) with zones of partial preservation (ZPP) by using the HAL as a temporary training tool...
May 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/28460342/anterior-lumbar-interbody-fusion-with-percutaneous-pedicle-screw-fixation-for-multiple-level-isthmic-spondylolisthesis
#20
Chang-Sheng Hsieh, Hyung Chang Lee, Hyeong-Seok Oh, Sang-Joon Park, Byeong-Wook Hwang, Sang-Ho Lee
OBJECTIVE: Multiple-level lumbar isthmic spondylolisthesis is rarely reported. Here, we report 23 consecutive patients who underwent anterior lumbar interbody fusion (ALIF) with percutaneous pedicle screw fixation (PPF) for multiple-level isthmic spondylolisthesis. PATIENTS AND METHODS: From June 2008 through December 2014, multiple-level lumbar isthmic spondylolisthesis was diagnosed in 23 patients (6 men, 17 women) at Wooridul Spine Hospital (Busan, South Korea)...
April 13, 2017: Clinical Neurology and Neurosurgery
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