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https://www.readbyqxmd.com/read/28430420/a-thorium-chalcogenolate-series-generated-by-atom-insertion-into-thorium-carbon-bonds
#1
Nicholas S Settineri, Mary E Garner, John Arnold
A new thorium monoalkyl complex, Th(CH2SiMe3)(L3) (L = MeC(N(i)Pr)2) (2), undergoes insertion of chalcogen atoms resulting in a series of thorium chalcogenolate complexes, Th(ECH2SiMe3)(L3) (E = S, SS, Se, Te; 5-8). Complex 6 represents the first alkyl disulfide thorium species and illustrates the ability of 2 to undergo controllable, stoichiometric atom insertion. All complexes have been characterized by (1)H and (13)C NMR spectroscopy, FTIR, EA, and melting point, and in the case of 1, 2, and 4-8, X-ray crystallography...
April 21, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28418095/the-nuclear-orphan-receptor-nr4a1-regulates-%C3%AE-1-integrin-expression-in-pancreatic-and-colon-cancer-cells-and-can-be-targeted-by-nr4a1-antagonists
#2
Erik Hedrick, Syng-Ook Lee, Stephen Safe
β1-Integrin is highly expressed and is a negative prognostic factor for colon and pancreatic cancer patients and the gene plays a functional role in cell migration and invasion. In this study, we demonstrate that β1-integrin expression is regulated in pancreatic and colon cancer cells by the pro-oncogenic orphan nuclear receptor 4A1 (NR4A1, Nur77, TR3) and knockdown of this receptor by RNA interference decreases β1-integrin protein and mRNA expression, α5-integrin and also expression of β1-integrin-dependent phosphorylation of FAK (pFak)...
April 18, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28418046/novel-nickel-ii-complexes-of-sterically-modified-linear-n4-ligands-effect-of-ligand-stereoelectronic-factors-and-solvent-of-coordination-on-nickel-ii-spin-state-and-catalytic-alkane-hydroxylation
#3
Muniyandi Sankaralingam, Prabha Vadivelu, Mallayan Palaniandavar
A series of Ni(ii) complexes of the types [Ni(L)(CH3CN)2](BPh4)21-3, 5 and [Ni(L4)](BPh4)24, where L = N,N'-bis(2-pyrid-2-ylmethyl)-1,4-diazepane (L1), N-(6-methylpyrid-2-ylmethyl)-N'-(pyrid-2-ylmethyl)-1,4-diazepane (L2), N,N'-bis(6-methyl-2-pyridylmethyl)-1,4-diazepane (L3), N,N'-dimethyl-N,N'-bis(2-pyridylmethyl)ethylenediamine (L5) and L4 = N,N'-bis((1-methyl-1H-imidazole-2-yl)methyl)-1,4-diazepane, have been isolated and characterized. The complex cations of 1 and 4 possess, respectively, distorted octahedral and low-spin square planar coordination geometries in which nickel(ii) is meridionally coordinated to all four nitrogen atoms of L1 and L4...
April 18, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28412369/structural-basis-for-ribosome-protein-s1-interaction-with-rna-in-trans-translation-of-mycobacterium-tuberculosis
#4
Yi Fan, Yazhuang Dai, Meijing Hou, Huilin Wang, Hongwei Yao, Chenyun Guo, Donghai Lin, Xinli Liao
Ribosomal protein S1 (RpsA), the largest 30S protein in ribosome, plays a significant role in translation and trans-translation. In Mycobacterium tuberculosis, the C-terminus of RpsA is known as tuberculosis drug target of pyrazinoic acid, which inhibits the interaction between MtRpsA and tmRNA in trans-translation. However, the molecular mechanism underlying the interaction of MtRpsA with tmRNA remains unknown. We herein analyzed the interaction of the C-terminal domain of MtRpsA with three RNA fragments poly(A), sMLD and pre-sMLD...
April 12, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28408216/modelling-the-impacts-of-pasture-contamination-and-stocking-rate-for-the-development-of-targeted-selective-treatment-strategies-for-ostertagia-ostertagi-infection-in-calves
#5
Zoe Berk, Yan C S M Laurenson, Andrew B Forbes, Ilias Kyriazakis
A simulation study was carried out to assess whether variation in pasture contamination or stocking rate impact upon the optimal design of targeted selective treatment (TST) strategies. Two methods of TST implementation were considered: 1) treatment of a fixed percentage of a herd according to a given phenotypic trait, or 2) treatment of individuals that exceeded a threshold value for a given phenotypic trait. Four phenotypic traits, on which to base treatment were considered: 1) average daily bodyweight gain, 2) faecal egg count, 3) plasma pepsinogen, or 4) random selection...
March 28, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28405646/half-sandwich-iridium-n-heterocyclic-carbene-anticancer-complexes
#6
Chuanlan Wang, Jinfeng Liu, Zhenzhen Tian, Meng Tian, Laijin Tian, Wenqian Zhao, Zhe Liu
Half-sandwich pseudo-octahedral pentamethylcyclopentadienyl Ir(III) complexes of the type [(η(5)-Cp(x))Ir(C^C)Cl]PF6, where Cp(x) is pentamethylcyclopentadienyl (Cp*), or its phenyl (Cp(xph) = C5Me4C6H5) or biphenyl (Cp(xbiph) = C5Me4C6H4C6H5) derivatives, and the C^C-chelating ligands are different N-heterocyclic carbene (NHC) ligands, have been synthesized and characterized. Three X-ray crystal structures have been determined. Except for Cp* complex 1A, the other eleven complexes 1B-4C all showed potent cytotoxicity, with IC50 values ranging from 2...
April 13, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28399545/propionibacterium-acnes-incubation-in-the-discs-can-result-in-time-dependent-modic-changes-a-long-term-rabbit-model
#7
Zhi Shan, Xuyang Zhang, Shengyun Li, Tianming Yu, Junhui Liu, Fengdong Zhao
STUDY DESIGN: A case control study of animal model of Modic changes (MCs) on Rabbits. OBJECTIVE: To evaluate the feasibility of inducing of MCs by injection of Propionibacterium acne (P. acnes) into the lumbar intervertebral discs of rabbits. SUMMARY OF BACKGROUND DATA: MCs have been widely observed, and assume to be closely associated with low back pain and P. acnes, but there are few animal models showing the progression of MCs. METHODS: Ten rabbits were used for the study...
April 10, 2017: Spine
https://www.readbyqxmd.com/read/28398110/molecular-characterization-of-hypoderma-spp-in-domestic-ruminants-from-turkey-and-pakistan
#8
Haroon Ahmed, Sami Simsek, Cem Ecmel Saki, Harun Kaya Kesik, Seyma Gunyakti Kilinc
The aim of this study was to determine the morphological and molecular characterization of Hypoderma spp. in cattle and yak from different provinces of Turkey and Pakistan. For this purpose, a total of 78 larvae were collected from different provinces of Turkey and Pakistan from October (2015) to January (2016) from slaughtered animals. Thirty eight out of 78 Hypoderma larvae were morphologically classified as third instar larvae (L3) of Hypoderma bovis, 37 were Hypoderma lineatum and 3 were classified as suspected or un-identified...
April 11, 2017: Journal of Parasitology
https://www.readbyqxmd.com/read/28391070/can-haemonchus-placei-primary-infected-na%C3%A3-ve-lambs-withstand-haemonchus-contortus-infections
#9
Regina Celis Pereira Reiniger, Luciana Laitano Dias de Castro, Magda Vieira Benavides, Maria Elisabeth Aires Berne
An experiment was conducted with the objective of evaluating whether a 5000 L3 larvae Haemonchus placei primary infection, a less pathogenic parasite species for sheep, could attenuate highly pathogenic Haemonchus contortus infections in lambs. Thirty nine 6-month-old lambs were divided in three primary-infection groups: (HcPI) H. contortus-primary infected lambs, (HpPI) H. placei-primary infected lambs, and (CTRL) non-infected control lambs. Later, these same individuals, then aged 10-month old, were cross challenged with Haemonchus parasite species, creating four groups: HcPI challenged with H...
February 28, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28389885/anatomical-evaluation-of-lumbar-nerves-using-diffusion-tensor-imaging-and-implications-of-lateral-decubitus-for-lateral-transpsoas-approach
#10
Yasuhiro Oikawa, Yawara Eguchi, Atsuya Watanabe, Sumihisa Orita, Kazuyo Yamauchi, Miyako Suzuki, Yoshihiro Sakuma, Go Kubota, Kazuhide Inage, Takeshi Sainoh, Jun Sato, Kazuki Fujimoto, Masao Koda, Takeo Furuya, Koji Matsumoto, Yoshitada Masuda, Yasuchika Aoki, Kazuhisa Takahashi, Seiji Ohtori
PURPOSE: Recently, lateral interbody fusion (LIF) has become more prevalent, and evaluation of lumbar nerves has taken on new importance. We report on the assessment of anatomical relationships between lumbar nerves and vertebral bodies using diffusion tensor imaging (DTI). METHODS: Fifty patients with degenerative lumbar disease and ten healthy subjects underwent DTI. In patients with lumbar degenerative disease, we studied nerve courses with patients in the supine positions and with hips flexed...
April 7, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28386725/biomechanical-properties-of-posterior-transpedicular-transdiscal-oblique-lumbar-screw-fixation-with-novel-trapezoidal-lateral-interbody-spacer-an-in-vitro-human-cadaveric-model
#11
Ai-Min Wu, Jonathan A Harris, John C Hao, Sean M Jenkins, Yong-Long Chi, Brandon S Bucklen
PURPOSE: To investigate biomechanical properties of posterior transpedicular-transdiscal (TPTD) oblique lumbar screw fixation whereby the screw traverses the inferior pedicle across the posterior disc space into the super-adjacent body and lateral trapezoidal interbody spacer. METHODS: Eight fresh-frozen osteoligamentous human cadaveric spines (L1-S1) were tested in flexion-extension (FE), lateral bending (LB), and axial rotation (AR), with pure bending moment set at 7...
April 6, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28386320/a-novel-approach-for-the-annulus-needle-puncture-model-of-intervertebral-disc-degeneration-in-rabbits
#12
Tao Lei, Yuan Zhang, Qiang Zhou, Xiaoji Luo, Ke Tang, Rongsheng Chen, Chang Yu, Zhengxue Quan
OBJECTIVE: To create the rabbit animal model of intervertebral disc (IVD) degeneration by the annulus needle puncture technique through a novel transabdominal approach. METHODS: Thirteen New Zealand White rabbits underwent annular puncture at the L3/4, L4/5, and L5/6 discs through a transabdominal approach. For a longitudinal study to assess changes in disc height over time, serial X-rays, T2-weighted magnetic resonance imaging (MRI) (T2WI), and T2 mapping MRI were performed pre-operation and at 2, 4, and 6 weeks after puncture...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28377644/finite-element-analysis-of-sagittal-balance-in-different-morphotype-forces-and-resulting-strain-in-pelvis-and-spine
#13
REVIEW
Vincenzo Filardi, Portaro Simona, Giorgio Cacciola, Salvatore Bertino, Luigi Soliera, Andrea Barbanera, Alessandro Pisani, Demetrio Milardi, Bramanti Alessia
In humans, vertical posture acquisition caused several changes in bones and muscles which can be assumed as verticalization. Pelvis, femur, and vertebral column gain an extension position which decreases muscular work by paravertebral muscles in the latter. It's widely known that six different morphological categories exist; each category differs from the others by pelvic parameters and vertebral column curvatures. Both values depend on the Pelvic Incidence, calculated as the angle between the axes passing through the rotation centre of the two femur heads and the vertical axis passing through the superior plate of the sacrum...
June 2017: Journal of Orthopaedics
https://www.readbyqxmd.com/read/28377309/abdominal-girth-vertebral-column-length-and-spread-of-intrathecal-hyperbaric-bupivacaine-in-the-term-parturient
#14
Chang-Na Wei, Yin-Fa Zhang, Feng Xia, Li-Zhong Wang, Qing-He Zhou
BACKGROUND: We aimed to test whether abdominal girth and vertebral column length were predictors of spinal hyperbaric bupivacaine spread in term parturients. METHODS: A total of 128 parturients having elective caesarean section under spinal anaesthesia were enrolled. Combined spinal-epidural anaesthesia was performed at the L3/4 interspace, confirmed by ultrasonography. Two millilitres of 0.5% hyperbaric bupivacaine was injected intrathecally and spinal spread assessed at three minute intervals...
February 27, 2017: International Journal of Obstetric Anesthesia
https://www.readbyqxmd.com/read/28376780/kinematic-characteristics-of-lumbar-spinous-processes-during-axial-rotation-in-patients-with-lumbar-degenerative-disc-disease-lateral-lumbar-interbody-fusion-and-intervention
#15
BaoLiang Zhang, Wenhan Huang, Hong Xia, Xinglong Feng
BACKGROUND: Data about minimally invasive surgery for the treatment of patients with degenerative disc disease (DDD) has been reported. However, no quantitative knowledge about the biomechanical characteristics of the spinous processes in patients with DDD after operation was reported in the literature. METHODS: Fourteen adult patients with DDD at the L3-4 level were recruited and scanned using computed tomography (CT) to construct three-dimensional (3D) anatomical vertebral models of L2-5...
April 4, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28373626/high-intensity-zone-in-lumbar-spine-and-its-correlation-with-disc-degeneration
#16
Subash C Jha, Yoichiro Takata, Mitsunobu Abe, Kazuta Yamashita, Fumitake Tezuka, Toshinori Sakai, Kosaku Higashino, Akihiro Nagamachi, Koichi Sairyo
Purpose; To investigate the prevalence, clinical significance of high intensity zone (HIZ), and associated disc degeneration. Materials and methods; We undertook retrospective analysis of 228 patients, aged from 15 to 55 years, who had undergone magnetic resonance (MR) imaging of lumbar spine in outpatient clinic from 2013 to 2014. HIZ was defined as a presence of high intensity signal in the annulus on T2-weighted images. All HIZ positive discs were classified according to Pfirrmann grading system for presence of disc degeneration...
2017: Journal of Medical Investigation: JMI
https://www.readbyqxmd.com/read/28373080/is-a-gradual-reduction-of-stiffness-on-top-of-posterior-instrumentation-possible-with-a-suitable-proximal-implant-a-biomechanical-study
#17
Tobias Lange, Werner Schmoelz, Georg Gosheger, Martin Eichinger, Christian H Heinrichs, Albert Schulze Bövingloh, Tobias L Schulte
BACKGROUND CONTEXT: Proximal junctional kyphosis (PJK) is a challenging complication after rigid posterior instrumentation (RI) of the spine. Several risk factors have been described in literature so far, including the rigidity of the cranial aspect of the implant. PURPOSE: The aim of this biomechanical study was to compare different proximal implants designed to gradually reduce the stiffness between the instrumented and non-instrumented spine. STUDY DESIGN/SETTING: This is a biomechanical study...
March 31, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28371249/osteoid-osteoma-benign-osteoblastic-tumor-of-the-lumbar-l4-transverse-process-associated-with-radicular-pain-a-case-report
#18
Carlos L Nebreda, Ricardo Vallejo, Victor Mayoral-Rojals, Antonio Ojeda
Osteoid osteomas of the spine are benign bone tumors typically presenting with progressive pain without neurological deficit. This report presents a case of an osteoid osteoma in the lumbar spine associated with radicular pain. The patient, a young male athlete, presented with severe chronic nightly left low back pain radiated to the ipsilateral lower extremity who failed to respond to physical therapy and analgesic medications. Initial radiologic examination was reported as normal, but closer inspection of the T1- and T2-weighted magnetic resonance image as well as technetium-99m total body bone scan and a computed tomography scan revealed a bony lesion in the left transverse process of the L4 vertebra consistent with the diagnosis of osteoid osteoma...
March 30, 2017: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/28352485/lateral-lumbar-interbody-fusion-for-ossification-of-the-yellow-ligament-in-the-lumbar-spine-first-reported-case
#19
Kengo Fujii, Tetsuya Abe, Toru Funayama, Hiroshi Noguchi, Keita Nakayama, Kousei Miura, Katsuya Nagashima, Hiroshi Kumagai, Masashi Yamazaki
When ossification of the yellow ligament (OYL) occurs in the lumbar spine and extends to the lateral wall of the spinal canal, facetectomy is required to remove all of the ossified lesion and achieve decompression. Subsequent posterior fixation with interbody fusion will then be necessary to prevent postoperative progression of the ossification and intervertebral instability. The technique of lateral lumbar interbody fusion (LLIF) has recently been introduced. Using this procedure, surgeons can avoid excess blood loss from the extradural venous plexus and detachment of the ossified lesion and the ventral dura mater is avoidable...
2017: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/28342975/biomechanical-testing-of-a-peek-based-dynamic-instrumentation-device-in-a-lumbar-spine-model
#20
Christian Herren, Agnes Beckmann, Sabine Meyer, Miguel Pishnamaz, Marion Mundt, Rolf Sobottke, Andreas Prescher, Marcus Stoffel, Bernd Markert, Philipp Kobbe, Hans-Christoph Pape, Peer Eysel, Jan Siewe
BACKGROUND: The purpose of this study was to investigate the range-of-motion after posterior polyetheretherketone-based rod stabilisation combined with a dynamic silicone hinge in order to compare it with titanium rigid stabilisation. METHODS: Five human cadaveric lumbar spines with four vertebra each (L2 to L5) were tested in a temperature adjustable spine-testing set-up in four trials: (1) native measurement; (2) kinematics after rigid monosegmental titanium rod instrumentation with anterior intervertebral bracing of the segment L4/5; (3) kinematics after hybrid posterior polyetheretherketone rod instrumentation combined with a silicone hinge within the adjacent level (L3/4) and (4) kinematics after additional decompression with laminectomy of L4 and bilateral resection of the inferior articular processes (L3)...
March 18, 2017: Clinical Biomechanics
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