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https://www.readbyqxmd.com/read/28072800/modified-percutaneous-lumbar-foraminoplasty-and-percutaneous-endoscopic-lumbar-discectomy-instrument-design-technique-notes-and-5-years-follow-up
#1
Zhen-Zhou Li, Shu-Xun Hou, Wei-Lin Shang, Ke-Ran Song, Hong-Liang Zhao
BACKGROUND: Conventional percutaneous endoscopic lumbar discectomy (PELD) with an "inside-outside" technique has 4.3% - 10.3% surgical failure rate, especially in central herniated discs (HDs), migrated HDs, and axillary type HDs. PELD with foraminoplasty has been used for complex HDs. Percutaneous lumbar foraminoplasty (PLF), which is performed with a trephine or bone reamer introduced over a guidewire without a protective working cannula in the original Tessys technique, can quickly cut the hypertrophied bony structure under fluoroscopic guidance, and risk injury to the exiting and traversing nerve roots...
January 2017: Pain Physician
https://www.readbyqxmd.com/read/28068753/retrospective-matched-pair-cohort-study-on-effect-of-bisegmental-fenestration-versus-hemilaminectomy-for-bisegmental-spinal-canal-stenosis-at-l3-l4-and-l4-l5
#2
Julia Schüppel, Friedrich Weber
Background The main symptoms of degenerative lumbar spinal canal stenosis are progressive back pain, spinal claudication, and, occasionally, sensory and motor deficits. Impairments particularly occur during walking, standing, and sitting. Thus social and vocational activities are increasingly restricted, causing considerable suffering for patients. Surgical therapies are superior to conservative ones. This article studies the outcome of 2-level fenestration versus hemilaminectomy for bisegmental spinal stenosis decompression...
January 9, 2017: Journal of Neurological Surgery. Part A, Central European Neurosurgery
https://www.readbyqxmd.com/read/28065817/reproducibility-of-sagittal-radiographic-parameters-in-adolescent-idiopathic-scoliosis-a-guide-to-reference-values-using-serial-imaging
#3
Hwee Weng Dennis Hey, Gordon Chengyuan Wong, Chloe Chan Xiaoyun, Leok-Lim Lau, Naresh Kumar, Joseph Shantakumar Thambiah, John Nathaniel Ruiz, Ka-Po Gabriel Liu, Hee-Kit Wong
BACKGROUND CONTEXT: Knowledge of sagittal radiographical parameters in AIS patients has not yet caught up with our understanding of their roles in patients with adult spinal deformity. It is likely that more emphasis will be placed in restoring sagittal parameters for AIS patients in the future. Therefore we need to understand how these parameters may vary in AIS to facilitate management plans. PURPOSE: To determine the reproducibility of sagittal spinal parameters on lateral film radiographs in patients with AIS...
January 5, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28063162/serum-mediated-haemonchus-contortus-larval-aggregation-differs-by-larval-stage-and-is-enhanced-by-complement
#4
Javier J Garza, Scott P Greiner, Scott A Bowdridge
The objectives of this study were to measure Haemonchus contortus larval aggregation by complement/antibody complexes, determine effect of breed resistance and infection status, and determine the effect of larval maturation on larval aggregation in vitro. Larval binding assays were performed on H. contortus L3, exsheathed L3 and L4 incubated with serum from either parasite naïve or H. contortus primed St. Croix (resistant) and Suffolk (susceptible) lambs. No differences in L3 aggregation were observed between serum from either breed or infection status...
January 7, 2017: Parasite Immunology
https://www.readbyqxmd.com/read/28059506/local-and-global-dynamics-in-klebsiella-pneumoniae-outer-membrane-protein-a-in-lipid-bilayers-probed-at-atomic-resolution
#5
Olivier Saurel, Iordan Orlinov Iordanov, Guillaume Nars, Pascal Demange, Tanguy Le Marchand, Loren B Andreas, Guido Pintacuda, Alain Milon
The role of membrane proteins in cellular mechanism strongly depends on their dynamics and solid-state Magic-Angle Spinning (MAS) Nuclear Magnetic Resonance (NMR) is a unique method to exhaustively characterize motions of proteins in a lipid environment. Herein, we make use of advances in 1H-detected MAS NMR to describe the dynamics of the membrane domain of the Outer membrane protein A of Klebsiella pneumoniae (KpOmpA). By measuring 1H-15N dipolar-coupling as well as 15N R1 and R1ρ relaxation rates at fast (60 kHz) MAS and high magnetic field (1 GHz), we were able to describe the motions of the residues of the β-barrel as a collective rocking of low amplitude and of hundreds of nano-seconds time scale...
January 6, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28057996/a-case-report-on-buccal-mucosa-graft-for-upper-ureteral-stricture-repair
#6
Vilas Pandurang Sabale, Naveen Thakur, Sharad Kumar Kankalia, Vikram Pramod Satav
Management of ureteric stricture especially long length upper one-third poses a challenging job for most urologists. With the successful use of buccal mucosa graft (BMG) for stricture urethra leads the foundation for its use in ureteric stricture also. A 35-year-old male diagnosedcase of left upper ureteric stricture, postureteroscopy with left percutaneous nephrostomy (PCN) in situ. Cysto-retrograde pyelography and nephrostogram done simultaneously suggestive of left upper ureteric stricture of 3 cm at L3 level...
October 2016: Urology Annals
https://www.readbyqxmd.com/read/28052082/crohn-s-disease-localization-displays-different-predisposing-genetic-variants
#7
Orazio Palmieri, Fabrizio Bossa, Maria Rosa Valvano, Giuseppe Corritore, Tiziana Latiano, Giuseppina Martino, Renata D'Incà, Salvatore Cucchiara, Maria Pastore, Mario D'Altilia, Daniela Scimeca, Giuseppe Biscaglia, Angelo Andriulli, Anna Latiano
BACKGROUND: Crohn's disease (CD) is a pathologic condition with different clinical expressions that may reflect an interplay between genetics and environmental factors. Recently, it has been highlighted that three genetic markers, NOD2, MHC and MST1, were associated to distinct CD sites, supporting the concept that genetic variations may contribute to localize CD. Genetic markers, previously shown to be associated with inflammatory bowel disease (IBD), were tested in CD patients with the aim to better dissect the genetic relationship between ileal, ileocolonic and colonic CD and ascertain whether a different genetic background would support the three disease sites as independent entities...
2017: PloS One
https://www.readbyqxmd.com/read/28040610/the-impact-of-metastasis-on-the-mineral-phase-of-vertebral-bone-tissue
#8
Mikhail Burke, Ayelet Atkins, Alex Kiss, Margarete Akens, Albert Yee, Cari Whyne
The negative impact of metastases on the mechanical performance of vertebral bone is often attributed to reduced bone density and/or compromised architecture. However limited characterization has been done on the impact of metastasis on the mineralization of bone tissue and resulting changes in material behaviour. This study aimed to evaluate the impact of metastasis on micro and nano scale characteristics of the mineral phase of bone, specifically mineral crystal growth, homogeneity of mineralization and changes in intrinsic material properties...
December 23, 2016: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28032300/genotypic-and-phenotypic-evaluation-for-benzimidazole-resistance-or-susceptibility-in-haemonchus-contortus-isolates
#9
Waleed M Arafa, Patricia J Holman, Thomas M Craig
Haemonchus contortus isolates were evaluated for benzimidazole (BZ) resistance or susceptibility by allele-specific PCR based on β-tubulin isotype 1 gene polymorphisms at the F167Y, E198A, and F200Y sites. Two isolates, one presumed susceptible from wild pronghorn antelope (PH) and one known to be resistant from goats (VM), were also assayed phenotypically for BZ resistance or susceptibility in the larval development assay (Drenchrite®). The BZ EC50 was 0.198 μM (intermediate between susceptible and weak resistant) for PH with critical well 5 (intermediate between susceptible and weak resistant) and 1...
December 28, 2016: Parasitology Research
https://www.readbyqxmd.com/read/28030710/association-of-radiologic-indicators-of-frailty-with-1-year-mortality-in-older-trauma-patients-opportunistic-screening-for-sarcopenia-and-osteopenia
#10
Stephen J Kaplan, Tam N Pham, Saman Arbabi, Joel A Gross, Mamatha Damodarasamy, Itay Bentov, Lisa A Taitsman, Steven H Mitchell, May J Reed
Importance: Assessment of physical frailty in older trauma patients admitted to the intensive care unit is often not feasible using traditional frailty assessment instruments. The use of opportunistic computed tomography (CT) scans to assess sarcopenia and osteopenia as indicators of underlying frailty may provide complementary prognostic information on long-term outcomes. Objective: To determine whether sarcopenia and/or osteopenia are associated with 1-year mortality in an older trauma patient population...
December 28, 2016: JAMA Surgery
https://www.readbyqxmd.com/read/28027145/chance-fractures-in-the-pediatric-population-are-often-misdiagnosed
#11
Lindsay M Andras, Kira F Skaggs, Haleh Badkoobehi, Paul D Choi, David L Skaggs
BACKGROUND: Flexion injuries of the spine range from mild compression fractures to severe flexion-distraction injuries, that is, Chance fractures. Chance fractures are often unstable and Arkader and colleagues demonstrated improved outcomes when Chance fractures are treated operatively compared with those managed nonoperatively. METHODS: A retrospective review was conducted of all patients treated over a 5-year period (2008 to 2013) for a flexion injury, either a Chance or a compression fracture, of the thoracolumbar spine at our tertiary pediatric level I trauma center...
December 23, 2016: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28024891/transdural-herniated-lumbar-disc-disease-with-muscle-patch-for-closure-of-durotomy-a-brief-review-of-literature
#12
REVIEW
Harsha A Huliyappa, Rakesh Kumar Singh, Sunil Kumar Singh, Manish Jaiswal, Somil Jaiswal, Chhitij Srivastava, Balkrishna Ojha, Anil Chandra, Satnam Chhabra
PURPOSE: Intradural migration of disc (IDMD) is a rare clinical entity accounting for 0.27-0.33% of all herniated disc diseases. Flimsy or dense adhesion between the ventral dural surface and the opposing posterior longitudinal ligament (PLL) is the principal pathology for intradural migrated disc. The most commonly affected lumbar segments are L4-5 (55%), L3-4 (16%), L5-S1 (10%) and less commonly L2L3 and L1L2. No imaging feature is characteristic and the management protocol of durotomy via an endoscopic method is unclear...
December 15, 2016: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/28017169/the-effect-of-intra-articular-levobupivacaine-on-shoulder-cartilage-at-different-doses-experimental-study
#13
Mustafa Soner Özcan, Mahmut Kalem, Menekşe Özçelik, Ercan Şahin, Sanem Çakar, Nazlı Hayırlı, Oya Evirgen, Feyhan Ökten
BACKGROUND AND OBJECTIVES: In this study it was aimed to examine the histological and morphometric effects on cartilage structure of intra-articular application of levobupivacaine to the shoulder joint. METHODS: In twenty New Zealand adult male rabbits, 35 shoulders were used for the study and prepared in 5 groups of 7. These groups were defined as Groups L1, L2, L3 and L4 which were right shoulders administered with 0.25% and 0.5% levobupivacaine, Group C which were left shoulders as the control group and Groups S1 and S2 which were left shoulders administered with 0...
January 2017: Brazilian Journal of Anesthesiology
https://www.readbyqxmd.com/read/28002369/transient-local-bone-remodeling-effects-of-rhbmp-2-in-an-ovine-interbody-spine-fusion-model
#14
Hyun W Bae, Vikas V Patel, Zeeshan M Sardar, Jeffrey M Badura, Ben B Pradhan, Howard B Seim, A Simon Turner, Jeffrey M Toth
BACKGROUND: Recombinant human bone morphogenetic protein-2 (rhBMP-2) is a powerful osteoinductive morphogen capable of stimulating the migration of mesenchymal stem cells (MSCs) to the site of implantation and inducing the proliferation and differentiation of these MSCs into osteoblasts. Vertebral end-plate and vertebral body resorption has been reported after interbody fusion with high doses of rhBMP-2. In this study, we investigated the effects of 2 rhBMP-2 doses on peri-implant bone resorption and bone remodeling at 7 time points in an end-plate-sparing ovine interbody fusion model...
December 21, 2016: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/27995638/in-vitro-and-in-vivo-studies-of-the-native-isolates-of-nematophagous-fungi-from-china-against-the-larvae-of-trichostrongylides
#15
Bo-Bo Wang, Feng-Hui Wang, Qiang Xu, Kang-Ying Wang, Yu-Jia Xue, Rui Ren, Jia-Qing Zeng, Yang Liu, Hai-Yan Zhang, Hai-Yu Wang, Bin Cai, Kui-Zheng Cai, Xin Cao
To screen potential nematophagous fungi candidates for the biological control of parasitic nematodes in livestock, in vitro and in vivo studies of the native isolates of nematophagous fungi against the larvae of trichostrongylides were conducted. The in vitro predatory activity of 16 native nematophagous fungal isolates on the larvae of trichostrongylides in sheep feces was assessed. In the ten isolates of Duddingtonia flagrans, the reduction percentage for the infective larvae (L3) of Trichostrongylus colubriformis ranged from 57...
December 20, 2016: Journal of Basic Microbiology
https://www.readbyqxmd.com/read/27995332/synthesis-of-ni-ii-complexes-bearing-indole-based-thiosemicarbazone-ligands-for-interaction-with-biomolecules-and-some-biological-applications
#16
Jebiti Haribabu, Kumaramangalam Jeyalakshmi, Yuvaraj Arun, Nattamai S P Bhuvanesh, Paramasivan Thirumalai Perumal, Ramasamy Karvembu
A series of new Ni(II) complexes containing indole-based thiosemicarbazone ligands was synthesized and characterized by elemental analyses, and UV-visible, FT-IR, (1)H & (13)C NMR and mass spectroscopic techniques. The Ni(II) complexes (1-4) bear the general formula [Ni{C10H9N2NHCSNH(R)}2] where R = hydrogen (1), 4-methyl (2), 4-phenyl (3) and 4-cyclohexyl (4). Molecular structure of ligands (L3 and L4) and complexes (2, 3 and 4) was confirmed by single crystal X-ray crystallography. Four coordinated Ni(II) complexes showed square planar geometry...
December 19, 2016: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/27977025/selective-synthesis-of-iridium-iii-derived-molecular-borromean-rings-2-catenane-and-ring-in-ring-macrocycles-via-coordination-driven-self-assembly
#17
Nem Singh, Dongwook Kim, Dong Hwan Kim, Eun-Hee Kim, Hyunuk Kim, Myoung Soo Lah, Ki-Whan Chi
This paper reports the formation of unprecedented iridium(iii)-derived topological macrocycles. Discrete molecular Borromean rings 1 and 3 in pure form are synthesized via coordination-driven self-assembly of an acceptor [(Cp*Ir)2(OO∩OO)](OTf)2 (Cp* = pentamethylcyclopentadienyl, OO∩OO = 6,11-dioxido-5,12-naphthacenedione) (A) with dipyridyl donors 1,4-bis(4-pyridinylethynyl)benzene (L1) and 2,5-bis(4-pyridinylethynyl)thiophene (L2) respectively in methanol. Self-assembly using the same acceptor under similar conditions with two other donors 9,10-bis(4-pyridinylethynyl)anthracene (L3) and 1,4-di(4-pyridinylethynyl)buta-1,3-diyne (L4) resulted in [2]catenane 5 and non-catenane ring-in-ring topological macrocycle 7 respectively...
January 3, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27942941/migratory-low-velocity-intradural-lumbosacral-spinal-bullet-causing-cauda-equina-syndrome-report-of-a-case-and-review-of-literature
#18
Sachin Baldawa, Vijay Shivpuje
BACKGROUND: Migration of the bullet within the spinal subarachnoid space has long been recognized as unusual complication of spinal gunshot injury. OBJECTIVE: We report a case of migratory low velocity intradural lumbosacral spinal bullet causing cauda equina syndrome. The relevant literature is reviewed and all cases of migratory spinal bullet are summarised, and management strategies are discussed. STUDY DESIGN: Literature review. METHODS: A 32-year-old male suffered abdominal gunshot injury for which emergency laparotomy and repair of colonic perforation were performed...
December 9, 2016: European Spine Journal
https://www.readbyqxmd.com/read/27939398/intradural-extramedullary-ewing-s-sarcoma-a-case-report-and-review-of-the-literature
#19
Konstantinos Paterakis, Alexandros Brotis, Anastasia Tasiou, Vasiliki Kotoula, Eftychia Kapsalaki, Marianna Vlychou
INTRODUCTION: Extra-skeletal Ewing's sarcomas are very rare lesions to the spine surgeon, with the intradural, extramedullary lesions being even rarer. Herein we present a patient with an intradural, extramedullary form of Ewing's sarcoma and review the relevant literature. The medical records, operative reports, radiographical studies and histological examinations of a single patient are retrospectively reviewed. CASE REPORT: A 31-year old male presented with back-pain, right-leg progressive paraparesis, and inability to walk...
November 30, 2016: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/27936479/the-galad-scoring-algorithm-based-on-afp-afp-l3-and-dcp-significantly-improves-detection-of-bclc-early-stage-hepatocellular-carcinoma
#20
J Best, H Bilgi, D Heider, C Schotten, P Manka, S Bedreli, M Gorray, J Ertle, L A van Grunsven, A Dechêne
Background: Hepatocellular carcinoma (HCC) is one of the leading causes of death in cirrhotic patients worldwide. The detection rate for early stage HCC remains low despite screening programs. Thus, the majority of HCC cases are detected at advanced tumor stages with limited treatment options. To facilitate earlier diagnosis, this study aims to validate the added benefit of the combination of AFP, the novel biomarkers AFP-L3, DCP, and an associated novel diagnostic algorithm called GALAD. Material and methods: Between 2007 and 2008 and from 2010 to 2012, 285 patients newly diagnosed with HCC and 402 control patients suffering from chronic liver disease were enrolled...
December 2016: Zeitschrift Für Gastroenterologie
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