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https://www.readbyqxmd.com/read/29232030/reproducibility-of-relaxometry-of-human-lumbar-vertebrae-at-3-tesla-using-1-h-mr-spectroscopy
#1
Bernhard Neumayer, Thomas Widek, Rudolf Stollberger, Eva Scheurer
BACKGROUND: MR spectroscopy is widely used for fat fraction quantification of human lumbar vertebrae. However, the measurements need to be corrected for relaxation effects. PURPOSE: The aim of this study was to determine the reproducibility of relaxometry in human lumbar vertebrae required for the correction of fat fraction measurements using magnetic resonance spectroscopy at 3 Tesla. Such information provides error estimates and guidance regarding reliability for future studies...
December 12, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29227104/x-ray-absorption-spectroscopy-combined-with-time-dependent-density-functional-theory-elucidates-differential-substitution-pathways-of-au-i-and-au-iii-with-zinc-fingers
#2
Camilla Abbehausen, Raphael Enoque Ferraz de Paiva, Ragnar Bjornsson, Saulo Quintana Gomes, Zhifeng Du, Pedro Paulo Corbi, Frederico Alves Lima, Nicholas Farrell
A combination of two elements' (Au, Zn) X-ray absorption spectroscopy (XAS) and time-dependent density functional theory (TD-DFT) allowed the elucidation of differential substitution pathways of Au(I) and Au(III) compounds reacting with biologically relevant zinc fingers (ZnFs). Gold L3-edge XAS probed the interaction of gold and the C-terminal Cys2HisCys finger of the HIV-1 nucleocapsid protein NCp7, and the Cys2His2 human transcription factor Sp1. The use of model compounds helped assign oxidation states and the identity of the gold-bound ligands...
December 11, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29218717/genetic-composition-of-a-population-of-natural-common-bream-abramis-brama%C3%A2-%C3%A3-%C3%A2-roach-rutilus-rutilus-hybrids-and-their-morphological-characteristics-in-comparison-with-parent-species
#3
M K Konopiński, A Amirowicz
Common bream Abramis brama, roach Rutilus rutilus and their hybrids were collected in the Dobczyce Reservoir in southern Poland in 2006-2013 to study whether it is better for a hybrid individual to resemble and compete with one of its parents, or to minimize competition by having a distinctive phenotype. All hybrids were F1 crosses and originated predominantly (93·2%) from matings between female A. brama and male R. rutilus parents. In morphometric analyses, a newly defined coefficient, L3  = 2·5 (body mass) (LS  × body depth)-1 , which enables forms with similar length-depth proportions but different length-mass relationships to be distinguished was used...
December 7, 2017: Journal of Fish Biology
https://www.readbyqxmd.com/read/29215586/investigation-of-polyamine-metabolism-and-homeostasis-in-pancreatic-cancers
#4
Chelsea Massaro, Jenna Thomas, Otto Phanstiel Iv
Pancreatic cancers are currently the fourth leading cause of cancer-related death and new therapies are desperately needed. The most common pancreatic cancer is pancreatic ductal adenocarcinoma (PDAC). This report describes the development of therapies, which effectively deplete PDAC cells of their required polyamine growth factors. Of all human tissues, the pancreas has the highest level of the native polyamine spermidine. To sustain their high growth rates, PDACs have altered polyamine metabolism, which is reflected in their high intracellular polyamine levels and their upregulated import of exogenous polyamines...
December 7, 2017: Medical Sciences: Open Access Journal
https://www.readbyqxmd.com/read/29214371/biomechanical-investigation-of-lumbar-hybrid-stabilization-in-two-level-posterior-instrumentation
#5
Aldemar Andres Hegewald, Sebastian Hartmann, Alexander Keiler, Kai Michael Scheufler, Claudius Thomé, Werner Schmoelz
PURPOSE: Hybrid stabilization with a dynamic implant has been suggested to avoid adjacent segment disease by creating a smoother transition zone from the instrumented segments to the untreated levels above. This study aims to characterize the transition zones of two-level posterior instrumentation strategies for elucidating biomechanical differences between rigid fixation and the hybrid stabilization approach with a pedicle screw-based dynamic implant. METHODS: Eight human lumbar spines (L1-5) were loaded in a spine tester with pure moments of 7...
December 6, 2017: European Spine Journal
https://www.readbyqxmd.com/read/29202859/complications-of-lumbar-disc-herniations-following-trans-sacral-epiduroscopic-lumbar-decompression-a-single-center-retrospective-study
#6
Seung-Kook Kim, Su-Chan Lee, Seung-Woo Park, Eun-Sang Kim
BACKGROUND: Trans-sacral epiduroscopic lumbar decompression (SELD) is an emerging procedure for the treatment of lumbar disc herniation (LDH), with favorable outcomes having been reported. However, the complications associated with SELD have not been comprehensively evaluated to date. Therefore, the aim of our study was to describe the incidence rate, types, and characteristics of complications following SELD and management outcomes. METHODS: Retrospective analysis of the surgical and clinical outcomes for 127 patients (average age, 42...
December 4, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29201857/a-rare-complication-of-lumbar-spinal-surgery-pneumocephalus
#7
Uğur Özdemir
A 25-year-old male patient with severe thigh and right side pain was presented. In the lumbar magnetic resonance images, there was a contrasting spinal cord tumor image with 1 cm in diameter at the level of the L3 vertebra. The patient was operated and the tumor was totally removed. All the pain of the patient recovered. The patient's postoperative two days were very comfortable and the patient was early mobilized. On the third postoperative day, the patient complained of severe headache, nausea and vomiting...
October 2017: Korean Journal of Neurotrauma
https://www.readbyqxmd.com/read/29200482/computer-simulation-of-two-level-pedicle-subtraction-osteotomy-for-severe-thoracolumbar-kyphosis-in-ankylosing-spondylitis
#8
Ning Zhang, Hao Li, Zheng-Kuan Xu, Wei-Shan Chen, Qi-Xin Chen, Fang-Cai Li
Background: Advanced ankylosing spondylitis is often associated with thoracolumbar kyphosis, resulting in an abnormal spinopelvic balance and pelvic morphology. Different osteotomy techniques have been used to correct AS deformities, unfortunnaly, not all AS patients can gain spinal sagittal balance and good horizontal vision after osteotomy. Materials and Methods: Fourteen consecutive AS patients with severe thoracolumbar kyphosis who were treated with two-level PSO were studied retrospectively...
November 2017: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/29193023/alpha-defensins-%C3%AE-defs-in-crohn-s-disease-decrease-of-ileal-%C3%AE-def-5-via-permanent-methylation-and-increase-in-plasma-%C3%AE-def-1-3-concentrations-offering-biomarker-utility
#9
Elena Cerrillo, Inés Moret, Marisa Iborra, David Ramos, Enrique Busó, Luis Tortosa, Esteban Sáez-González, Pilar Nos, Belén Beltrán
BACKGROUND: An impaired expression of α-defensins (α-Defs) in the ileal mucosa and, conversely, increased levels in plasma, have been reported in Crohn's disease (CD). However, the specificity and correlation of these findings with the degree of inflammation are unclear. We aimed to characterize the concentration and utility of ileal and plasma α-Defs in CD and to analyze a potential epigenetic mechanism of α-Def expression. METHODS: Peripheral blood samples and ileal biopsies were obtained from patients at disease onset (aCD), from those who achieved remission (iCD), and from 2 control groups (healthy controls and non-CD-etiology ileitis patients)...
November 28, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29182985/assessment-of-metal-pollution-in-the-lambro-creek-italy
#10
Bijay Gurung, Marco Race, Massimiliano Fabbricino, Dana Komínková, Giovanni Libralato, Antonietta Siciliano, Marco Guida
This study assessed the effect of metal pollution in the Lambro Creek (Southern Italy). Water, sediment and biota were collected at six sampling sites (June) for metal concentration assessment (Cr, Cu, Ni, Pb and Zn). Sequential extraction was performed to determine the distribution of metals in different geochemical sediment fractions. The influence of pH and leaching time on the release of metals from sediment to the water column was investigated via remobilization tests. A battery of toxicity tests (Vibrio fischeri, Raphidocelis subcapitata, Phaeodactylum tricornutum, and Daphnia magna) with multi-endpoints (bioluminescence, growth inhibition, and immobilization) was used to determine the overall toxicity in sediment water extracts...
November 25, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29173538/serological-detection-of-ascaris-suum-at-fattening-pig-farms-is-linked-with-performance-and-management-indices
#11
J M Martínez-Pérez, E Vandekerckhove, J Vlaminck, P Geldhof, M Martínez-Valladares
The aim of the present study was to determine the association between the presence of Ascaris suum at fattening pig farms, using different serological methods and the percentage of affected livers at slaughter, with performance and management indices. In total, 21 fattening pig farms from the North of Spain were included in the study. Serum samples were collected from pigs at slaughter and analysed for the presence of anti-Ascaris antibodies. For this, two different ELISAs were used. The first was based on the antibody recognition of the A...
December 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/29169540/retroperitoneoscopic-lumbar-sympathectomy-for-plantar-hyperhidrosis
#12
Sonia O Lima, Vanessa R de Santana, Daisy P Valido, Renata L B de Andrade, Leticia M Fontes, Victor Hugo O Leite, José M Neto, Jéssica M Santos, Lucas L Varjão, Francisco P Reis
OBJECTIVE: The objective of this study was to assess the reduction in quality of life (QoL) caused by the persistence of primary plantar hyperhidrosis (PPH) symptoms and the level of satisfaction in PPH patients after retroperitoneoscopic lumbar sympathectomy (RLS). The efficacy, safety, and procedure of bilateral RLS in both sexes are also described in this study. METHODS: This is a longitudinal study of consecutive patients who sought specific treatment from a private practitioner for severe PPH as classified on the Hyperhidrosis Disease Severity Scale (HDSS) from October 2005 to October 2014...
December 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29166933/correlation-between-facet-tropism-and-lumbar-degenerative-disease-a-retrospective-analysis
#13
Tian Gao, Qi Lai, Song Zhou, Xuqiang Liu, Yuan Liu, Ping Zhan, Xiaolong Yu, Jun Xiao, Min Dai, Bin Zhang
BACKGROUND: The aim of this study was to investigate the correlation between facet tropism and spinal degenerative diseases, such as degenerative lumbar spondylolisthesis, degenerative lumbar scoliosis, and lumbar disc herniation. METHODS: This study retrospectively analysed clinical data from the Department of Orthopaedics at The First Affiliated Hospital of Nanchang University. Ninety-two patients were diagnosed with lumbar spondylolisthesis, 64 patients with degenerative scoliosis, and 86 patients with lumbar disc herniation between 1 October 2014 and 1 October 2016...
November 22, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29164752/spinal-cord-stimulation-with-conventional-clinical-and-higher-frequencies-on-activity-and-responses-of-spinal-neurons-to-noxious-stimuli-an-animal-study
#14
Shiying Li, Jay P Farber, Bengt Linderoth, Jiande Chen, Robert D Foreman
OBJECTIVES: Spinal cord stimulation (SCS) at both conventional and higher frequencies may effectively reduce pain, but optimal parameters need to be established. This study investigated how SCS at different frequencies and pulse widths acutely modulates nociceptive activity of wide dynamic range (WDR) and high threshold (HT) dorsal horn neurons in rats at a stimulus amplitude that influences both local circuits and dorsal column fibers. MATERIALS AND METHODS: L2 -L3 and L6 -S2 spinal segments were exposed for SCS and spinal neuronal recordings, respectively...
November 22, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29146435/epidemiology-and-management-of-spinal-trauma-in-children-and-adolescents-under-18-years-old
#15
Asdrubal Falavigna, Orlando Righesso, Pedro Guarise da Silva, Felix Adolfo Sanchez Chavez, Ericson Sfreddo, Leandro Pelegrini de Almeida, Manuel Jose Valencia Carrasco, Andrei Fernandes Joaquim
STUDY DESIGN: Retrospective study. OBJECTIVE: Report the epidemiology, clinical aspects and management of spinal trauma in children and adolescents. METHODS: Multicenter study of 215 cases of spinal trauma in individuals younger than 18 years of age. All patients were submitted to preoperative and postoperative radiological and clinical evaluation. The fractures were classified according to the AOSpine fracture classification. Neurological evaluation was performed using the Frankel Scale at admission to hospital and at the last follow-up...
November 13, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29145287/transforaminal-endoscopy-in-lumbar-burst-fracture-a-case-report
#16
Yuanyi Wang, Cong Ning, Liyu Yao, Xiuying Huang, Chengliang Zhao, Bin Chen, Nan Zhang
RATIONALE: Lumbar burst fractures are frequent injury resulting from high-energy trauma, and the patients suffer from pain and the neurologic dysfunction. Although minimally invasive techniques have advanced rapidly, it was the first time to apply transforaminal endoscopic combined with percutaneous pedicle screw fixation to treatment of lumbar burst fractures. PATIENT CONCERNS: A 33-year-old man underwent Magerl type A3.1 burst fracture at L2 and compression fractures at L3 due to falling from a height with severe lower back pain, sensory loss, and atony of the right leg...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29143683/the-progression-of-heartworm-associated-respiratory-disease-hard-in-spf-cats-18%C3%A2-months-after-dirofilaria-immitis-infection
#17
A Ray Dillon, Bryon L Blagburn, Michael Tillson, William Brawner, Betsy Welles, Calvin Johnson, Russell Cattley, Pat Rynders, Sharron Barney
BACKGROUND: Heartworm-associated respiratory disease (HARD) in cats is induced by the arrival and death of immature adult Dirofilaria immitis in the pulmonary system and is indistinguishable from mature adult heartworm infection. METHODS: A controlled, blind research study investigated the long-term (18 months post infection, PI) consequences of the inflammatory response associated with the death of immature adult heartworms in cats. Three groups of cats, 10 per group, were infected with 100 third-stage (L3) larvae by subcutaneous injection...
November 9, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/29143661/heartworm-associated-respiratory-disease-hard-induced-by-immature-adult-dirofilaria-immitis-in-cats
#18
A Ray Dillon, Byron L Blagburn, Michael Tillson, William Brawner, Betsy Welles, Calvin Johnson, Russell Cattley, Pat Rynders, Sharron Barney
BACKGROUND: A controlled, blind research study was conducted to define the initial inflammatory response and lung damage associated with the death of immature adult Dirofilaria immitis in cats as compared with cats developing adult heartworm infections and cats on preventive medication. METHODS: Three groups of cats were utilized, 10 per group. All cats were infected with 100 third-stage (L3) larvae by subcutaneous injection. Group A cats were treated topically with selamectin (Revolution®; Zoetis) per label directions at 28 days post infection (PI) and once monthly for 8 months...
November 9, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/29143659/effect-of-heartworm-disease-and-heartworm-associated-respiratory-disease-hard-on-the-right-ventricle-of-cats
#19
Randolph L Winter, A Ray Dillon, Russell C Cattley, Byron L Blagburn, D Michael Tillson, Calvin M Johnson, William R Brawner, Elizabeth G Welles, Sharon Barney
BACKGROUND: Dirofilaria immitis infection occurs in dogs and cats, both of which species are clinically affected by mature adult infections. Cats are uniquely affected by immature-adult infections with an inflammatory pulmonary disease called Heartworm-Associated Respiratory Disease (HARD). D. immitis infection causes pulmonary parenchymal and vascular pathology in the dog and cat. Dogs develop pulmonary hypertension and cor pulmonale, whereas the development of pulmonary hypertension is rare in the cat...
November 9, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/29143654/evaluation-of-the-efficacy-of-proheart-%C3%A2-6-moxidectin-against-a-resistant-isolate-of-dirofilaria-immitis-jyd-34-in-dogs
#20
Dwight D Bowman, Tom L McTier, Eric L Adams, Sean P Mahabir, Joyce A Login, Tara Bidgood, Debra J Woods
BACKGROUND: In a previous study, it was demonstrated that ProHeart(®) 6 (PH6) (moxidectin, Zoetis) provided only about 20% efficacy in a small six-dog study against a macrocyclic lactone -resistant Dirofilaria immitis isolate (Jd2009-2) when dogs were inoculated with infective third-stage larvae (L3) at the end of the dosing period (ie, 180 days post treatment). The objective of the current study was to determine the prophylactic efficacy of a moxidectin sustained-release formulation (PH6) against a confirmed macrocyclic lactone-resistant isolate of D...
November 9, 2017: Parasites & Vectors
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