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https://www.readbyqxmd.com/read/29471553/-the-role-of-organizational-indicators-within-the-implementation-of-cross-sectoral-mental-health-care-and-home-treatment-in-germany-a-literature-and-theory-review
#1
Christian Klode, Tilman Steinert, Andreas Blume, Peter Brückner-Bozetti, Aysin Senkal, Michael Lingenfelder
OBJECTIVE: To elucidate organizational and human resource management-related drivers of community mental health services and home treatment in Germany. METHODS: Systematic review of psychiatric and organizational science literature, additional manual search. RESULTS: Relevant driver variables in community mental health services and home treatment have mostly been addressed. However, only a few have been evaluated and complex cause-and-effect models are missing so far...
February 22, 2018: Psychiatrische Praxis
https://www.readbyqxmd.com/read/29471492/corrigendum-towards-recommendations-for-metadata-and-data-handling-in-plant-phenotyping
#2
Pawel Krajewski, Dijun Chen, Hanna Cwiek, Aalt D J van Dijk, Fabio Fiorani, Paul Kersey, Christian Klukas, Matthias Lange, Augustyn Markiewicz, Jan Peter Nap, Jan van Oeveren, Cyril Pommier, Uwe Scholz, Marco van Schriek, Björn Usadel, Stephan Weise
No abstract text is available yet for this article.
February 19, 2018: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29471433/reply-to-godbole-et-al
#3
Stefan Schlabe, Carola-Ellen Kleine, Gunnar T R Hischebeth, Ernst Molitor, Yvonne Pfeifer, Jan-Christian Wasmuth, Ulrich Spengler
No abstract text is available yet for this article.
February 17, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29471172/enhancing-glioblastoma-treatment-using-cisplatin-gold-nanoparticle-conjugates-and-targeted-delivery-with-magnetic-resonance-guided-focused-ultrasound
#4
Daniel Coluccia, Carlyn A Figueiredo, Megan YiJun Wu, Alexandra N Riemenschneider, Roberto Diaz, Amanda Luck, Christian Smith, Sunit Das, Cameron Ackerley, Meaghan O'Reilly, Kullervo Hynynen, James T Rutka
Glioblastoma (GBM) is the most common and aggressive primary brain tumor resulting in high rates of morbidity and mortality. A strategy to increase the efficacy of available drugs and enhance the delivery of chemotherapeutics through the blood brain barrier (BBB) is desperately needed. We investigated the potential of Cisplatin conjugated gold nanoparticles (GNP-UP-Cis) in combination with MR-guided Focused Ultrasound (MRgFUS) to intensify GBM treatment. Viability assays demonstrated that GNP-UP-Cis greatly inhibits the growth of GBM cells compared to free cisplatin and shows marked synergy with radiation therapy...
February 19, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/29471068/weight-loss-decreases-self-reported-appetite-and-alters-food-preferences-in-overweight-and-obese-adults-observational-data-from-the-diogenes-study
#5
Charlotte Andriessen, Pia Christensen, Lone Vestergaard Nielsen, Christian Ritz, Arne Astrup, Thomas Meinert Larsen, J Alfredo Martinez, Wim H M Saris, Marleen A van Baak, Angeliki Papadaki, Marie Kunesova, Susan Jebb, John Blundell, Clare Lawton, Anne Raben
People with obesity often struggle to maintain their weight loss after a weight loss period. Furthermore, the effect of weight loss on appetite and food preferences remains unclear. Hence this study investigated the effect of weight loss on subjective appetite and food preferences in healthy, overweight and obese volunteers. A subgroup of adult participants (n = 123) from the Diet Obesity and Genes (DiOGenes) study (subgroup A) was recruited from across six European countries. Participants lost ≥8% of initial body weight during an 8-week low calorie diet (LCD)...
February 19, 2018: Appetite
https://www.readbyqxmd.com/read/29471063/intermolecular-interactions-determined-by-noe-build-up-in-macromolecules-from-hyperpolarized-small-molecules
#6
Chia-Hsiu Chen, Yunyi Wang, Christian Hilty
The nuclear Overhauser effect (NOE) is a primary means to characterize intermolecular interactions using modern NMR spectroscopy. Multiple experiments measured using different mixing time can be used for quantifying NOE buildup and measuring cross-relaxation rates. However, this approach using conventional multi-dimensional NMR is time consuming. Hyperpolarization by dissolution dynamic nuclear polarization (D-DNP) can generate deviations from equilibrium spin polarization by orders of magnitude, thereby enhancing signals and allowing to characterize NOE build up in real-time...
February 19, 2018: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/29471000/relationship-between-cerebrospinal-fluid-concentrations-of-orexin-a-hypocretin-1-and-body-composition-in-humans
#7
João C P Santiago, Markus Otto, Werner Kern, Paul Christian Baier, Manfred Hallschmid
The hypothalamic neuropeptide orexin A (hypocretin-1) is a key signal in sleep/wake regulation and promotes food intake. We investigated the relationship between cerebrospinal fluid orexin A concentrations and body composition in non-narcoleptic human subjects with a wide range of body weight to gain insight into the role of orexin A in human metabolism. We collected cerebrospinal fluid and blood samples and measured body composition by bioelectric impedance analysis in 36 subjects (16 women and 20 men) with body mass indices between 16...
February 19, 2018: Peptides
https://www.readbyqxmd.com/read/29470650/management-of-knee-dislocation-prior-to-ligament-reconstruction-what-is-the-current-evidence-update-of-a-universal-treatment-algorithm
#8
REVIEW
Alexander Maslaris, Olaf Brinkmann, Matthias Bungartz, Christian Krettek, Michael Jagodzinski, Emmanouil Liodakis
Traumatic knee dislocation is a rare but potentially limb-threatening injury. Thus proper initial diagnosis and treatment up to final ligament reconstruction are extremely important and a precondition to successful outcomes. Reports suggest that evidence-based systematic approaches lead to better results. Because of the complexity of this injury and the inhomogeneity of related literature, there are still various controversies and knowledge gaps regarding decision-making and step-sequencing in the treatment of acute multi-ligament knee injuries and knee dislocations...
February 22, 2018: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/29470626/living-donor-liver-transplantation-post-operative-imaging-follow-up-of-right-lobe-liver-donors
#9
Tapas K Tejura, Alejandro Pita, Christian Romero, Yuri S Genyk, Linda Sher, Suzanne L Palmer
PURPOSE: To identify long-term post-operative imaging findings resulting from right lobe liver donation. METHODS: This retrospective imaging review consisted of 42 adults (20 males, 22 females, mean age 36.6 years, range 18.7-55.9 years) who underwent right lobe liver donation with pre- and post-operative imaging between 1999 and 2006. The mean follow-up period was 30.2 months (range 12.3-69.6 months). Follow-up imaging evaluation included assessment of the biliary tree, particularly isolated bile ducts draining to and terminating at the cut surface (orphan ducts)...
February 22, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29470556/no-evidence-for-association-between-apol1-kidney-disease-risk-alleles-and-human-african-trypanosomiasis-in-two-ugandan-populations
#10
Magambo Phillip Kimuda, Harry Noyes, Julius Mulindwa, John Enyaru, Vincent Pius Alibu, Issa Sidibe, Dieuodonne Mumba Ngoyi, Christiane Hertz-Fowler, Annette MacLeod, Özlem Tastan Bishop, Enock Matovu
BACKGROUND: Human African trypanosomiasis (HAT) manifests as an acute form caused by Trypanosoma brucei rhodesiense (Tbr) and a chronic form caused by Trypanosoma brucei gambiense (Tbg). Previous studies have suggested a host genetic role in infection outcomes, particularly for APOL1. We have undertaken candidate gene association studies (CGAS) in a Ugandan Tbr and a Tbg HAT endemic area, to determine whether polymorphisms in IL10, IL8, IL4, HLAG, TNFA, TNX4LB, IL6, IFNG, MIF, APOL1, HLAA, IL1B, IL4R, IL12B, IL12R, HP, HPR, and CFH have a role in HAT...
February 22, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29470511/preliminary-analysis-of-proteome-alterations-in-non-aneurysmal-internal-mammary-artery-tissue-from-patients-with-abdominal-aortic-aneurysms
#11
Christina Lund Kidholm, Hans Christian Beck, Julie Bukh Madsen, Nikolai Bjødstrup Palstrøm, Jes Sanddal Lindholt, Lars Melholt Rasmussen
OBJECTIVE: The pathogenesis of abdominal aortic aneurysms (AAA) involves a disturbed balance of breakdown and buildup of arterial proteins. We envision that individuals with AAA carry generalized arterial protein alterations either because of effects of genetically or environmental AAA risk factors or because of compensatory changes due to signaling molecules released from the affected aneurysmal tissue. APPROACH: Protein extraction and quantitative proteome analysis by LC-MS/MS (liquid chromatography-mass spectrometry) was done on individual samples from the internal mammary artery from 11 individuals with AAA and 33 sex- and age-matched controls without AAA...
2018: PloS One
https://www.readbyqxmd.com/read/29470350/analysis-of-luminex-based-algorithms-to-define-unacceptable-hla-antibodies-in-cdc-crossmatch-negative-kidney-transplant-recipients
#12
Daniel Zecher, Christian Bach, Adrian Preiss, Christoph Staudner, Kirsten Utpatel, Matthias Evert, Bettina Jung, Tobias Bergler, Carsten A Böger, Bernd M Spriewald, Bernhard Banas
BACKGROUND: HLA-specific antibodies detected by solid phase assays are increasingly used to define unacceptable HLA antigen mismatches (UAM) prior to renal transplantation. The accuracy of this approach is unclear. METHODS: Day of transplant sera from 211 CDC-crossmatch-negative patients were retrospectively analyzed for donor-specific anti-HLA antibodies (DSA) using Luminex technology. HLA were defined as UAM if DSA had mean fluorescence intensity above (I) 3000 (patients retransplanted and those with DSA against HLA class I and II) or 5000 (all other patients), (II) 5000 for HLA A, B and DR and 10,000 for HLA DQ or (III) 10,000 (all HLA)...
February 20, 2018: Transplantation
https://www.readbyqxmd.com/read/29470324/response-to-letter-how-much-free-sugars-intake-should-be-recommended-for-children-younger-than-2-years-old
#13
Nataša Fidler Mis, Christian Braegger, Jiri Bronsky, Cristina Campoy, Magnus Domellöf, Nicholas D Embleton, Iva Hojsak, Jessie Hulst, Flavia Indrio, Alexandre Lapillonne, Walter Mihatsch, Christian Molgaard, Rakesh Vora, Mary Fewtrell
No abstract text is available yet for this article.
March 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29470262/serum-s100-proteins-as-a-marker-of-disease-activity-in-large-vessel-vasculitis
#14
Jason Michael Springer, Paul Monach, David Cuthbertson, Simon Carette, Nader A Khalidi, Carol A McAlear, Christian Pagnoux, Philip Seo, Kenneth J Warrington, Steven R Ytterberg, Gary Hoffman, Carol Langford, Thomas Hamilton, Dirk Foell, Thomas Vogl, Dirk Holzinger, Peter A Merkel, Johannes Roth, Rula A Hajj-Ali
No abstract text is available yet for this article.
February 22, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29470164/external-quality-assessment-for-zika-virus-molecular-diagnostic-testing-brazil
#15
Carlo Fischer, Celia Pedroso, Alfredo Mendrone, Ana Maria Bispo de Filippis, Antonio Carlos Rosário Vallinoto, Bergmann Morais Ribeiro, Edison Luiz Durigon, Ernesto T A Marques, Gubio S Campos, Isabelle F T Viana, José Eduardo Levi, Luciano Cesar Scarpelli, Mauricio Lacerda Nogueira, Michele de Souza Bastos, Nathalia C Santiago Souza, Ricardo Khouri, Sanny Lira, Shirley Vasconcelos Komninakis, Cécile Baronti, Rémi N Charrel, Beate M Kümmerer, Christian Drosten, Carlos Brites, Xavier de Lamballerie, Matthias Niedrig, Eduardo Martins Netto, Jan Felix Drexler
We conducted an external quality assessment of Zika virus molecular diagnostic tests in Brazil using a new Zika virus standard. Of 15 laboratories, 73% showed limited sensitivity and specificity. Viral load estimates varied significantly. Continuous quality assurance is needed to adequately estimate risk for Zika virus-associated disease and determine patient care.
May 17, 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29470107/leptospira-genomospecies-and-sequence-type-prevalence-in-small-mammal-populations-in-germany
#16
Stefan Fischer, Anne Mayer-Scholl, Christian Imholt, Nastasja G Spierling, Elisa Heuser, Sabrina Schmidt, Daniela Reil, Ulrike M Rosenfeld, Jens Jacob, Karsten Nöckler, Rainer G Ulrich
Leptospirosis is a worldwide emerging infectious disease caused by zoonotic bacteria of the genus Leptospira. Numerous mammals, including domestic and companion animals, can be infected by Leptospira spp., but rodents and other small mammals are considered the main reservoir. The annual number of recorded human leptospirosis cases in Germany (2001-2016) was 25-166. Field fever outbreaks in strawberry pickers, due to infection with Leptospira kirschneri serovar Grippotyphosa, were reported in 2007 and 2014. To identify the most commonly occurring Leptospira genomospecies, sequence types (STs), and their small mammal host specificity, a monitoring study was performed during 2010-2014 in four federal states of Germany...
February 22, 2018: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/29470059/low-pressure-nanofiltration-nf-hollow-fiber-membranes-for-effective-fractionation-of-dyes-and-inorganic-salts-in-textile-wastewater
#17
Gang Han, Tai-Shung Chung, Martin Weber, Christian Maletzko
In this work, novel loose nanofiltration (NF) hollow fiber membranes with ultrahigh water permeability and well-defined nanopore and surface charge characteristics were developed for effective fractionation of dyes and inorganic salts in textile wastewater treatment. The as-spun NF hollow fiber possesses a high pure water permeability (PWP) of 80 L.m-2.h-1.bar-1 with a small pore size of 1.0 nm in diameter and a MWCO of 1000 Da. The surface modification by means of hyperbranched polyethyleneimine (PEI) further lowers the pore diameter to 0...
February 22, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29469991/gene-expression-on-dna-biochips-patterned-with-strand-displacement-lithography
#18
Günther Pardatscher, Matthaeus Schwarz-Schilling, Shirley S Daube, Roy H Bar-Ziv, Friedrich Christian Simmel
Lithographic patterning of DNA molecules enables spatial organization of cell-free genetic circuits under well-controlled experimental conditions. Here, we present a biocompatible, DNA-based resist termed "Bephore" based on commercially available components, which can be patterned by both photo- and electron beam lithography. The patterning mechanism is based on cleavage of a chemically modified DNA hairpin by ultraviolet light or electrons, and a subsequent strand displacement reaction. All steps are performed in aqueous solution and do not require chemical development of the resist, which makes the lithographic process robust and biocompatible...
February 22, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29469822/autosomal-recessive-noonan-syndrome-associated-with-biallelic-lztr1-variants
#19
Jennifer J Johnston, Jasper J van der Smagt, Jill A Rosenfeld, Alistair T Pagnamenta, Abdulrahman Alswaid, Eva H Baker, Edward Blair, Guntram Borck, Julia Brinkmann, William Craigen, Vu Chi Dung, Lisa Emrick, David B Everman, Koen L van Gassen, Suleyman Gulsuner, Margaret H Harr, Mahim Jain, Alma Kuechler, Kathleen A Leppig, Donna M McDonald-McGinn, Ngoc Thi Bich Can, Amir Peleg, Elizabeth R Roeder, R Curtis Rogers, Lena Sagi-Dain, Julie C Sapp, Alejandro A Schäffer, Denny Schanze, Helen Stewart, Jenny C Taylor, Nienke E Verbeek, Magdalena A Walkiewicz, Elaine H Zackai, Christiane Zweier, Martin Zenker, Brendan Lee, Leslie G Biesecker
PurposeTo characterize the molecular genetics of autosomal recessive Noonan syndrome.MethodsFamilies underwent phenotyping for features of Noonan syndrome in children and their parents. Two multiplex families underwent linkage analysis. Exome, genome, or multigene panel sequencing was used to identify variants. The molecular consequences of observed splice variants were evaluated by reverse-transcription polymerase chain reaction.ResultsTwelve families with a total of 23 affected children with features of Noonan syndrome were evaluated...
February 22, 2018: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/29469690/non-canonical-escherichia-coli-transcripts-lacking-a-shine-dalgarno-motif-have-very-different-translational-efficiencies-and-do-not-form-a-coherent-group
#20
Petra Ludwig, Madeleine Huber, Matthias Lehr, Marius Wegener, Karolin Zerulla, Christian Lange, Joerg Soppa
Translation initiation in 50-70 % of transcripts in Escherichia coli requires base pairing between the Shine-Dalgarno (SD) motif in the mRNA and the anti-SD motif at the 3' end of the 16S rRNA. However, 30-50 % of E. coli transcripts are non-canonical and are not preceded by an SD motif. The 5' ends of 44 E. coli transcripts were determined, all of which contained a 5'-UTR (no leaderless transcripts), but only a minority contained an SD motif. The 5'-UTR lengths were compared with those listed in RegulonDB and reported in previous publications, and the identities and differences were obtained in all possible combinations...
February 22, 2018: Microbiology
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