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https://www.readbyqxmd.com/read/29667827/in-situ-x-ray-diffraction-study-of-the-thermal-decomposition-of-selenogallates-cs-2-ga-2-se-2-2-x-se-2-x-x-0-1-2
#1
Daniel Friedrich, Marc Schlosser, Christian Näther, Arno Pfitzner
The selenogallates CsGaSe3 and Cs2 Ga2 Se5 release gaseous selenium upon heating. An in situ high-temperature X-ray powder diffraction analysis revealed a two-step degradation process from CsGaSe3 to Cs2 Ga2 Se5 and finally to CsGaSe2 . During each step, one Se2 2- unit of the anionic chains in Cs2 [Ga2 (Se2 )2- x Se2+ x ] ( x = 0, 1, 2) decomposes, and one equivalent of selenium is released. This thermal decomposition can be reverted by simple addition of elemental selenium and subsequent annealing of the samples below the decomposition temperature...
April 18, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29667603/atomic-clocks-for-geodesy
#2
Tanja E Mehlstäubler, Gesine Grosche, Christian Lisdat, Piet O Schmidt, Heiner Denker
We review experimental progress on optical atomic clocks and frequency transfer, and consider the prospects of using these technologies for geodetic measurements. Today, optical atomic frequency standards have reached relative frequency inaccuracies below 10-17 , opening new fields of fundamental and applied research. The dependence of atomic frequencies on the gravitational potential makes atomic clocks ideal candidates for the search for deviations in the predictions of Einstein's general relativity, tests of modern unifying theories and the development of new gravity field sensors...
April 18, 2018: Reports on Progress in Physics
https://www.readbyqxmd.com/read/29667566/us-emergency-medical-services-fellows
#3
Brian Clemency, Christian Martin-Gill, Nicole Rall, Dipesh Patel, Jeffery Myers
IntroductionThe 2015-2016 academic year was the fourth year since the Accreditation Council for Graduate Medical Education (ACGME; Chicago, Illinois USA) accredited Emergency Medical Services (EMS) fellowships, and the first year an in-training examination was given. Soon, ACGME-accredited fellowship education will be the sole path to EMS board certification when the practice pathway closes after 2019. This project aimed to describe the current class of EMS fellows at ACGME-accredited programs and their current educational opportunities to better understand current and future needs in EMS fellowship education...
April 18, 2018: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/29667480/the-human-gut-microbiota-metabolism-and-perspective-in-obesity
#4
Aline Corado Gomes, Christian Hoffmann, João Felipe Mota
The gut microbiota has been recognized as an important factor in the development of metabolic diseases such as obesity and is considered an endocrine organ involved in the maintenance of energy homeostasis and host immunity. Dysbiosis can change the functioning of the intestinal barrier and the gut-associated lymphoid tissues (GALT) by allowing the passage of structural components of bacteria, such as lipopolysaccharides (LPS), which activate inflammatory pathways that may contribute to the development of insulin resistance...
April 18, 2018: Gut Microbes
https://www.readbyqxmd.com/read/29667434/health-literacy-is-it-important-for-cardiovascular-disease-prevention
#5
Christian Albus
No abstract text is available yet for this article.
January 1, 2018: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29667188/developing-protein-therapeutics
#6
EDITORIAL
Hanns-Christian Mahler
No abstract text is available yet for this article.
May 2018: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/29667121/backbone-1-h-13-c-and-15-n-resonance-assignments-of-the-ligand-binding-domain-of-the-human-wildtype-glucocorticoid-receptor-and-the-f602s-mutant-variant
#7
Christian Köhler, Göran Carlström, Stefan Tångefjord, Tineke Papavoine, Matti Lepistö, Karl Edman, Mikael Akke
The glucocorticoid receptor (GR) is a nuclear hormone receptor that regulates key genes controlling development, metabolism, and the immune response. GR agonists are efficacious for treatment of inflammatory, allergic, and immunological disorders. Steroid hormone binding to the ligand-binding domain (LBD) of GR is known to change the structural and dynamical properties of the receptor, which in turn control its interactions with DNA and various co-regulators and drive the pharmacological response. Previous biophysical studies of the GR LBD have required the use of mutant forms to overcome issues with limited protein stability and high aggregation propensity...
April 17, 2018: Biomolecular NMR Assignments
https://www.readbyqxmd.com/read/29667014/automatically-computed-ecg-algorithm-for-the-quantification-of-myocardial-scar-and-the-prediction-of-mortality
#8
Patrick Badertscher, Ivo Strebel, Ursina Honegger, Nicolas Schaerli, Deborah Mueller, Christian Puelacher, Max Wagener, Roger Abächerli, Joan Walter, Zaid Sabti, Lorraine Sazgary, Stella Marbot, Jeanne du Fay de Lavallaz, Raphael Twerenbold, Jasper Boeddinghaus, Thomas Nestelberger, Nikola Kozhuharov, Tobias Breidthardt, Samyut Shrestha, Dayana Flores, Carmela Schumacher, Damian Wild, Stefan Osswald, Michael J Zellweger, Christian Mueller, Tobias Reichlin
BACKGROUND: Myocardial scar is associated with adverse cardiac outcomes. The Selvester QRS-score was developed to estimate myocardial scar from the 12-lead ECG, but its manual calculation is difficult. An automatically computed QRS-score would allow identification of patients with myocardial scar and an increased risk of mortality. OBJECTIVES: To assess the diagnostic and prognostic value of the automatically computed QRS-score. METHODS: The diagnostic value of the QRS-score computed automatically from a standard digital 12-lead was prospectively assessed in 2742 patients with suspected myocardial ischemia referred for myocardial perfusion imaging (MPI)...
April 17, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29666918/procedure-specific-assessment-tool-for-flexible-pharyngo-laryngoscopy-gathering-validity-evidence-and-setting-pass-fail-standards
#9
Jacob Melchiors, K Petersen, T Todsen, A Bohr, Lars Konge, Christian von Buchwald
OBJECTIVE: The attainment of specific identifiable competencies is the primary measure of progress in the modern medical education system. The system, therefore, requires a method for accurately assessing competence to be feasible. Evidence of validity needs to be gathered before an assessment tool can be implemented in the training and assessment of physicians. This evidence of validity must according to the contemporary theory on validity be gathered from specific sources in a structured and rigorous manner...
April 17, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29666899/altered-mitochondrial-bioenergetics-and-ultrastructure-in-the-skeletal-muscle-of-young-adults-with-type-1-diabetes
#10
Cynthia M F Monaco, Meghan C Hughes, Sofhia V Ramos, Nina E Varah, Christian Lamberz, Fasih A Rahman, Chris McGlory, Mark A Tarnopolsky, Matthew P Krause, Robert Laham, Thomas J Hawke, Christopher G R Perry
AIMS/HYPOTHESIS: A comprehensive assessment of skeletal muscle ultrastructure and mitochondrial bioenergetics has not been undertaken in individuals with type 1 diabetes. This study aimed to systematically assess skeletal muscle mitochondrial phenotype in young adults with type 1 diabetes. METHODS: Physically active, young adults (men and women) with type 1 diabetes (HbA1c 63.0 ± 16.0 mmol/mol [7.9% ± 1.5%]) and without type 1 diabetes (control), matched for sex, age, BMI and level of physical activity, were recruited (n = 12/group) to undergo vastus lateralis muscle microbiopsies...
April 18, 2018: Diabetologia
https://www.readbyqxmd.com/read/29666888/precise-determination-of-protein-extinction-coefficients-under-native-and-denaturing-conditions-using-sv-auc
#11
Andreas Hoffmann, Kerstin Grassl, Janine Gommert, Christian Schlesak, Alexander Bepperling
The accurate determination of protein concentration is an important though non-trivial task during the development of a biopharmaceutical. The fundamental prerequisite for this is the availability of an accurate extinction coefficient. Common approaches for the determination of an extinction coefficient for a given protein are either based on the theoretical prediction utilizing the amino acid sequence or the photometric determination combined with a measurement of absolute protein concentration. Here, we report on an improved SV-AUC based method utilizing an analytical ultracentrifuge equipped with absorbance and Rayleigh interference optics...
April 17, 2018: European Biophysics Journal: EBJ
https://www.readbyqxmd.com/read/29666539/oxidative-status-of-a-yogurt-like-fermented-maize-product-containing-phytosterols
#12
Adriana María Descalzo, Sergio Aníbal Rizzo, Adrien Servent, Luciana Rossetti, Marc Lebrun, Carolina Daiana Pérez, Renaud Boulanger, Christian Mestres, Dominique Pallet, Claudie Dhuique-Mayer
This work describes the formulation of a functional yogurt-like product based on fermented maize with added phytosterols and its oxidative stability during cold storage. The technological challenge was to stabilize 3.5% esterified phytosterols (between 2 and 3 g of free sterols) in a low-fat emulsion and to preserve the obtained product throughout processing and storage. The natural bioactive compounds: lutein, zeaxanthin, β-cryptoxanthin, β-carotene and γ-tocopherol were detected in the yogurt, and remained stable during 12 days of refrigeration...
May 2018: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/29666476/hif1a-inactivation-rescues-photoreceptor-degeneration-induced-by-a-chronic-hypoxia-like-stress
#13
Maya Barben, Divya Ail, Federica Storti, Katrin Klee, Christian Schori, Marijana Samardzija, Stylianos Michalakis, Martin Biel, Isabelle Meneau, Frank Blaser, Daniel Barthelmes, Christian Grimm
Reduced choroidal blood flow and tissue changes in the ageing human eye impair oxygen delivery to photoreceptors and the retinal pigment epithelium. As a consequence, mild but chronic hypoxia may develop and disturb cell metabolism, function and ultimately survival, potentially contributing to retinal pathologies such as age-related macular degeneration (AMD). Here, we show that several hypoxia-inducible genes were expressed at higher levels in the aged human retina suggesting increased activity of hypoxia-inducible transcription factors (HIFs) during the physiological ageing process...
April 17, 2018: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29666159/extensive-identification-and-in-depth-validation-of-importin-13-cargoes
#14
Imke Baade, Christiane Spillner, Kerstin Schmitt, Oliver Valerius, Ralph H Kehlenbach
Importin 13 is a member of the importin b family of transport receptors. Unlike most family members, importin 13 mediates both, nuclear protein import and export. To search for novel importin 13 cargoes, we used stable isotope labeling of amino acids in cell culture (SILAC) and mass spectrometry. Using stringent criteria, we identified 255 importin 13 substrates, including the known cargoes Ubc9, Mago and eIF1A, and validate many of them as transport cargoes by extensive biochemical and cell biological characterization...
April 17, 2018: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/29666139/last-year-of-life-study-cologne-lyol-c-protocol-for-a-cross-sectional-mixed-methods-study-to-examine-care-trajectories-and-transitions-in-the-last-year-of-life-until-death
#15
Julia Strupp, Gloria Hanke, Nicolas Schippel, Holger Pfaff, Ute Karbach, Christian Rietz, Raymond Voltz
INTRODUCTION: The last year of life constitutes a particularly vulnerable phase for patients, involving nearly all health and social care structures. Yet, little scientific evidence is available that provides insight into the trajectories including the number and types of care setting transitions, transitions into palliative care and the dying phase. Only few studies have focused on difficulties associated with having to move between health and social care settings in the last year of life, although patients face a significant risk of adverse events...
April 17, 2018: BMJ Open
https://www.readbyqxmd.com/read/29665856/job-satisfaction-and-associated-factors-among-health-professionals-working-at-western-amhara-region-ethiopia
#16
Kalkidan Temesgen, Moges Wubie Aycheh, Cheru Tesema Leshargie
BACKGROUND: In Ethiopia assuring the satisfaction of health care provider with their job is a major challenging problem. Job satisfaction is a worker's emotional response to different job related factors resulting in finding pleasure, comfort, confidence, rewards, personal growth and various positive opportunities, including upward mobility, recognition, and appraisal done on a merit pattern with monetary value as compensation. Professionals, whose needs and expectations are satisfied, tend to be more productive compared to their colleagues...
April 17, 2018: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/29665821/plasma-proteomic-analysis-reveals-altered-protein-abundances-in-cardiovascular-disease
#17
Vasiliki Lygirou, Agnieszka Latosinska, Manousos Makridakis, William Mullen, Christian Delles, Joost P Schanstra, Jerome Zoidakis, Burkert Pieske, Harald Mischak, Antonia Vlahou
BACKGROUND: Cardiovascular disease (CVD) describes the pathological conditions of the heart and blood vessels. Despite the large number of studies on CVD and its etiology, its key modulators remain largely unknown. To this end, we performed a comprehensive proteomic analysis of blood plasma, with the scope to identify disease-associated changes after placing them in the context of existing knowledge, and generate a well characterized dataset for further use in CVD multi-omics integrative analysis...
April 17, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29665614/vo2max-testing-in-trail-runners-is-there-a-specific-exercise-test-protocol
#18
Volker Scheer, Katharina Ramme, Claus Reinsberger, Hans-Christian Heitkamp
Trail running places specific physiological demands on the human body due to its uphill and downhill running sections. We developed and investigated a more sport-specific trail exercise test protocol (inclination and speed incremental protocol), and compared it to two standard exercise test protocols (horizontal step and ramp protocol) in thirteen highly trained trail runners (age 31±6 years, height 179±6.4 cm, weight 69.2±7.9 kg, BMI 21.6±2.1 kg/m2 ). The maximum oxygen uptake (VO2 max) measured during the trail test (62...
April 17, 2018: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/29665587/interstitial-transpedal-mr-lymphangiography-of-central-lymphatics-using-a-standard-mr-contrast-agent-feasibility-and-initial-results-in-patients-with-chylous-effusions
#19
Claus Christian Pieper, Hans Heinz Schild
PURPOSE:  To describe a novel technique for transpedal magnetic resonance lymphangiography (tMRL) with interstitial injection of a standard gadolinium-based contrast agent, and to assess its ability to visualize the central lymphatic system (CLS) in patients with chylous effusions. MATERIALS AND METHODS:  Experiences with tMRL were retrospectively reviewed in seven patients with chylous effusions. High-resolution three-dimensional multi-echo (mDIXON) images of the entire torso were obtained before and after interstitial injection of an extracellular gadolinium-based contrast agent...
April 17, 2018: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/29665584/-is-there-an-association-between-dmp-enrollment-and-disability-pension-in-rehabilitants-with-type-2-diabetes
#20
Christian Schmidt, Bernd Hagen, Jens Baumert, Thomas Ziese
Efficacy of treatment of working-age patients with diabetes mellitus can be increased by rehabilitative measures. This treatment option is explicitly mentioned in the guidelines of the disease management program (DMP) for type 2 diabetes (T2D). With research data from the pension insurance fund, it is shown that for rehabilitation patients with T2D and DMP enrolment, the chance of disability pension is 23% lower than without DMP enrolment, irrespective of relevant covariates.
April 17, 2018: Das Gesundheitswesen
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