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https://www.readbyqxmd.com/read/29909492/modelling-glioma-invasion-using-3d-bioprinting-and-scaffold-free-3d-culture
#1
Derek M van Pel, Kaori Harada, Dandan Song, Christian C Naus, Wun Chey Sin
Glioma is a highly aggressive form of brain cancer, with some subtypes having 5-year survival rates of less than 5%. Tumour cell invasion into the surrounding parenchyma seems to be the primary driver of these poor outcomes, as most gliomas recur within 2 cm of the original surgically-resected tumour. Many current approaches to the development of anticancer therapy attempt to target genetic weaknesses in a particular cancer, but may not take into account the microenvironment experienced by a tumour and the patient-specific genetic differences in susceptibility to treatment...
June 16, 2018: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/29909471/pet-ct-and-prediction-of-thyroid-cancer-in-patients-with-follicular-neoplasm-or-atypia
#2
Thao T Nguyen, Natascha G E Lange, Anne L Nielsen, Anders Thomassen, Helle Døssing, Christian Godballe, Max Rohde
PURPOSE: To examine whether addition of 18 F-fluoro-deoxy-glucose positron emission tomography/computed tomography (FDG-PET/CT) to fine needle aspiration biopsy (FNAB) would improve prediction of thyroid cancer in patients with FNAB-derived follicular neoplasm or atypia, classified according to focal, multifocal, diffuse, or no FDG uptake. MATERIALS AND METHODS: Consecutive patients with FNAB-derived follicular neoplasm or atypia planned for surgery from September 2013 to March 2016 were prospectively included and considered for analysis...
June 16, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29909434/ionomer-and-protein-size-analysis-by-analytical-ultracentrifugation-and-electrospray-scanning-mobility-particle-sizer
#3
Simon E Wawra, Martin Thoma, Johannes Walter, Christian Lübbert, Thaseem Thajudeen, Cornelia Damm, Wolfgang Peukert
By combining analytical ultracentrifugation (AUC) in liquid phase and scanning mobility particle sizer (SMPS) in the gas phase, additional information on the particle size and morphology has been obtained for rigid particles. In this paper, we transfer this concept to soft particles, allowing us to analyze the size and molar mass of the short side chain perfluorosulfonic acid ionomer Aquivion® in a dilute aqueous suspension. The determination of the primary size and exact molar mass of this class of polymers is challenging since they are optically transparent and due to the formation of different aggregate structures depending on the concentration and solvent properties...
June 16, 2018: European Biophysics Journal: EBJ
https://www.readbyqxmd.com/read/29909433/pharmacokinetics-of-fentanyl-sublingual-spray-in-opioid-na%C3%A3-ve-participants-results-of-a-phase-1-multiple-ascending-dose-study
#4
Richard L Rauck, D Alexander Oh, Neil Singla, Christian Koch, Neha Parikh, Srinivas Nalamachu, Jin Yu, Steven James
BACKGROUND AND OBJECTIVES: Fentanyl sublingual spray may be a viable alternative to intravenous (IV) opioids for the treatment of acute pain. As patients with acute pain may include those who have limited prior exposure to opioids, this phase 1, open-label, randomized, multiple ascending-dose study was conducted to assess the pharmacokinetics, pharmacodynamics, safety, and tolerability of multiple doses of fentanyl sublingual spray in opioid-naïve participants. This article primarily reports the pharmacokinetics results...
June 16, 2018: Clinical Drug Investigation
https://www.readbyqxmd.com/read/29909408/design-and-baseline-characteristics-of-the-help-study-an-extended-and-long-term-observation-of-pathological-myopia-in-caucasians
#5
Charlotte Melzer, Focke Ziemssen, Nicole Eter, Christian Brinkmann, Hansjuergen Agostini, Gisela Haeusser-Fruh, Uwe Rose, Marc Schargus, Katrin Lorenz, Frank G Holz, Steffen Schmitz-Valckenberg
PURPOSE: To assess the natural disease progression of high myopia in Caucasians considered at risk for the development of myopic choroidal neovascularization (mCNV). METHODS: Subjects were recruited in 25 clinical sites between June 2014 and June 2016. Main inclusion criteria included axial length of ≥26 mm, best-corrected visual acuity ≥0.05 decimal equivalent and presence of at least one out of five predefined morphological disease risk criteria. These were (1) subfoveal choroidal thinning < 50 µm, (2) enhanced choroidal curvature length > 6,300 µm, (3) lacquer cracks, (4) patchy atrophy > 5 mm2 and (5) preexisting mCNV in the fellow eye (German Clinical Trial Register DRKS00007761)...
June 15, 2018: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/29908878/marked-prognostic-impact-of-minimal-lymphatic-tumor-spread-in-prostate-cancer
#6
Waldemar Wilczak, Corinna Wittmer, Till Clauditz, Sarah Minner, Stefan Steurer, Franziska Büscheck, Till Krech, Maximilian Lennartz, Luisa Harms, Diane Leleu, Marc Ahrens, Sebastian Ingwerth, Christian T Günther, Christina Koop, Ronald Simon, Frank Jacobsen, Maria C Tsourlakis, Viktoria Chirico, Doris Höflmayer, Eik Vettorazzi, Alexander Haese, Thomas Steuber, Georg Salomon, Uwe Michl, Lars Budäus, Derya Tilki, Imke Thederan, Christoph Fraune, Cosima Göbel, Marie-Christine Henrich, Manuela Juhnke, Katharina Möller, Ahmed Abdullah Bawahab, Ria Uhlig, Meike Adam, Sören Weidemann, Burkhard Beyer, Hartwig Huland, Markus Graefen, Guido Sauter, Thorsten Schlomm
BACKGROUND: Nodal metastasis (N1) is a strong prognostic parameter in prostate cancer; however, lymph node evaluation is always incomplete. OBJECTIVE: To study the prognostic value of lymphatic invasion (L1) and whether it might complement or even replace lymph node analysis in clinical practice. DESIGN, SETTING, AND PARTICIPANTS: Retrospective analysis of pathological and clinical data from 14 528 consecutive patients. INTERVENTION: Radical prostatectomy...
June 13, 2018: European Urology
https://www.readbyqxmd.com/read/29908588/evaluating-the-importance-of-environmental-persistence-for-ranavirus-transmission-and-epidemiology
#7
Jesse L Brunner, Christian M Yarber
Viruses persist outside their hosts in a variety of forms, from naked virions to virus protected in sloughed tissues or carcasses, and for a range of times, all of which affect the likelihood and importance of transmission from the environment. This review synthesizes the literature on environmental persistence of viruses in the genus Ranavirus (family Iridoviridae), which are large double-stranded DNA viruses of ectothermic, often aquatic or semiaquatic vertebrates. Ranaviruses have been associated with mass mortality events in natural and captive settings around the world, and with population and community-wide declines in Europe...
2018: Advances in Virus Research
https://www.readbyqxmd.com/read/29908404/the-association-between-cortisol-oxytocin-and-immune-cell-mitochondrial-oxygen-consumption-in-postpartum-women-with-childhood-maltreatment
#8
Christina Boeck, Anja Maria Gumpp, Enrico Calzia, Peter Radermacher, Christiane Waller, Alexander Karabatsiakis, Iris-Tatjana Kolassa
Childhood maltreatment (CM) is associated with an increased risk for the development of psychiatric and somatic diseases in later life. Individual risk and resilience factors may, however, influence how deep psychological stress gets under the skin. We hypothesized that the stress-related hormone cortisol and the attachment-related hormone oxytocin constitute biological factors that might moderate the biological sequelae and long-term health outcomes associated with CM. As biological outcome, we thereby focused on immunocellular oxygen consumption, which we previously found to be increased with a higher severity of CM experiences...
June 1, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29908370/gender-differences-in-patients-with-brugada-syndrome-and-arrhythmic-events-data-from-a-survey-on-arrhythmic-events-in-678-patients
#9
Anat Milman, Jean-Baptiste Gourraud, Antoine Andorin, Pieter G Postema, Frederic Sacher, Philippe Mabo, Giulio Conte, Carla Giustetto, Georgia Sarquella-Brugada, Aviram Hochstadt, Sung-Hwan Kim, Jimmy Jm Juang, Shingo Maeda, Yoshihide Takahashi, Tsukasa Kamakura, Takeshi Aiba, Eran Leshem, Yoav Michowitz, Michael Rahkovich, Yuka Mizusawa, Elena Arbelo, Zhengrong Huang, Isabelle Denjoy, Yanushi D Wijeyeratne, Carlo Napolitano, Ramon Brugada, Ruben Casado-Arroyo, Jean Champagne, Leonardo Calo, Jacob Tfelt-Hansen, Silvia G Priori, Masahiko Takagi, Christian Veltmann, Pietro Delise, Domenico Corrado, Elijah R Behr, Fiorenzo Gaita, Gan-Xin Yan, Josep Brugada, Antoine Leenhardt, Arthur A M Wilde, Pedro Brugada, Kengo F Kusano, Kenzo Hirao, Gi-Byoung Nam, Vincent Probst, Bernard Belhassen
BACKGROUND: There is limited information on gender differences in patients with Brugada syndrome (BrS) who experienced arrhythmic events (AEs). OBJECTIVES: To compare clinical, electrocardiographic (ECG), electrophysiologic (EP) and genetic characteristics between males and females in BrS-patients with their first AE. METHODS: The multicenter Survey on AE in BrS (SABRUS) collected data on first AE in 678 BrS-patients including 619 (91.3%) males and 59 (8...
June 13, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29908239/the-psychostimulant-%C3%A2-cis-4-4-dimethylaminorex-4-4-dmar-interacts-with-human-plasmalemmal-and-vesicular-monoamine-transporters
#10
Julian Maier, Felix P Mayer, Dino Luethi, Marion Holy, Kathrin Jäntsch, Harald Reither, Lena Hirtler, Marius C Hoener, Matthias E Liechti, Christian Pifl, Simon D Brandt, Harald H Sitte
(±)-cis-4,4'-Dimethylaminorex (4,4'-DMAR) is a new psychoactive substance (NPS) that has been associated with 31 fatalities and other adverse events in Europe between June 2013 and February 2014. We used in vitro uptake inhibition and transporter release assays to determine the effects of 4,4'-DMAR on human high-affinity transporters for dopamine (DAT), norepinephrine (NET) and serotonin (SERT). In addition, we assessed its binding affinities to monoamine receptors and transporters. Furthermore, we investigated the interaction of 4,4'-DMAR with the vesicular monoamine transporter 2 (VMAT2) in rat phaeochromocytoma (PC12) cells and synaptic vesicles prepared from human striatum...
June 13, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29908140/cryptosporidium-genotyping-in-europe-the-current-status-and-processes-for-a-harmonised-multi-locus-genotyping-scheme
#11
Rachel M Chalmers, Gregorio Pérez-Cordón, Simone M Cacció, Christian Klotz, Lucy J Robertson
Due to the occurrence of genetic recombination, a reliable and discriminatory method to genotype Cryptosporidium isolates at the intra-species level requires the analysis of multiple loci, but a standardised scheme is not currently available. A workshop was held at the Robert Koch Institute, Berlin in 2016 that gathered 23 scientists with appropriate expertise (in either Cryptosporidium genotyping and/or surveillance, epidemiology or outbreaks) to discuss the processes for the development of a robust, standardised, multi-locus genotyping (MLG) scheme and propose an approach...
June 13, 2018: Experimental Parasitology
https://www.readbyqxmd.com/read/29908039/no-neurodevelopmental-benefit-of-cerebral-oximetry-in-the-first-randomised-trial-in-preterm-infants-during-the-first-days-of-life-safeboosc-ii
#12
Anne M Plomgaard, Thomas Alderliesten, Frank van Bel, Manon Benders, Olivier Claris, Malaika Cordeiro, Eugene Dempsey, Monica Fumagalli, Christian Gluud, Simon Hyttel-Sorensen, Petra Lemmers, Adelina Pellicer, Gerhard Pichler, Gorm Greisen
AIM: Cerebral hypoxia has been associated with neurodevelopmental impairment. We studied whether reducing cerebral hypoxia in extremely preterm infants during the first 72 hours of life affected neurological outcomes at two years of corrected age. METHODS: In 2012-2013 the phase II randomised Safeguarding the Brains of our Smallest Children trial compared visible cerebral near infrared spectroscopy (NIRS) monitoring in an intervention group and blinded NIRS monitoring in a control group...
June 16, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29908036/acquired-von-willebrand-syndrome-in-congenital-heart-disease-surgery-results-from-an-observational-case-series
#13
Vanya Icheva, Martina Nowak-Machen, Ulrich Budde, Karl Jaschonek, Felix Neunhoeffer, Matthias Kumpf, Michael Hofbeck, Christian Schlensak, Gesa Wiegand
BACKGROUND: Cardiac surgery of the newborn and infant with complex congenital heart disease (CHD) is associated with a high rate of intraoperative bleeding complications. CHD-related anatomic features such as valve stenoses or patent arterial ducts can lead to enhanced shear stress in blood stream and thus cause acquired von Willebrand syndrome (aVWS). OBJECTIVE: To evaluate the intraoperative incidence and impact of aVWS after cardiopulmonary bypass (CPB) in neonates and infants with complex CHD...
June 16, 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29907989/high-seroprevalence-of-dengue-virus-indicates-that-dengue-virus-infections-are-frequent-in-central-and-eastern-sudan
#14
Awadalkareem Adam, Tom Schüttoff, Sven Reiche, Christian Jassoy
OBJECTIVES: To determine the seroprevalence of dengue in central and eastern Sudan and the breadth of neutralizing antibody responses. METHODS: Blood was drawn from 483 patients with fever who visited outpatient clinics in Port Sudan, Red Sea state, in three towns in Kassala state and in El Obeid, North Kordofan in December 2012 and January 2013. Sera were tested for dengue virus IgG and IgM by ELISA (Panbio) and sera without serologic evidence of acute infection (IgM negative) were used for the analysis of the seroprevalence...
June 15, 2018: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29907977/melatonin-induces-mechanisms-of-brain-resilience-against-neurodegeneration
#15
Rubén Corpas, Christian Griñán-Ferré, Verónica Palomera-Ávalos, David Porquet, Pablo García de Frutos, Silvia M Franciscato Cozzolino, Eduard Rodríguez-Farré, Mercè Pallàs, Coral Sanfeliu, Bárbara R Cardoso
Melatonin is an endogenous pleiotropic molecule which orchestrates regulatory functions and protective capacity against age-related ailments. The increase in circulating levels of melatonin through dietary supplements intensifies its health benefits. Investigations in animal models have shown that melatonin protects against Alzheimer's disease (AD)-like pathology, although clinical studies have not been conclusive. We hypothesized that melatonin induces changes in the brain that prevent or attenuate AD by increasing resilience...
June 15, 2018: Journal of Pineal Research
https://www.readbyqxmd.com/read/29907870/synergistic-activation-of-pro-inflammatory-type-2-cd8-t-lymphocytes-by-lipid-mediators-in-severe-eosinophilic-asthma
#16
Bart Hilvering, Timothy S C Hinks, Linda Stöger, Emanuele Marchi, Maryam Salimi, Rahul Shrimanker, Wei Liu, Wentao Chen, Jian Luo, Simei Go, Timothy Powell, Jennifer Cane, Samantha Thulborn, Ayako Kurioka, Tianqi Leng, Jamie Matthews, Clare Connolly, Catherine Borg, Mona Bafadhel, Christian B Willberg, Adaikalavan Ramasamy, Ratko Djukanović, Graham Ogg, Ian D Pavord, Paul Klenerman, Luzheng Xue
Human type-2 CD8+ T cells are a cell population with potentially important roles in allergic disease. We investigated this in the context of severe asthma with persistent airway eosinophilia-a phenotype associated with high exacerbation risk and responsiveness to type-2 cytokine-targeted therapies. In two independent cohorts we show that, in contrast to Th2 cells, type-2 cytokine-secreting CD8+ CRTH2+ (Tc2) cells are enriched in blood and airways in severe eosinophilic asthma. Concentrations of prostaglandin D2 (PGD2 ) and cysteinyl leukotriene E4 (LTE4 ) are also increased in the airways of the same group of patients...
June 15, 2018: Mucosal Immunology
https://www.readbyqxmd.com/read/29907749/focus-induced-photoresponse-a-novel-way-to-measure-distances-with-photodetectors
#17
Oili Pekkola, Christoph Lungenschmied, Peter Fejes, Anke Handreck, Wilfried Hermes, Stephan Irle, Christian Lennartz, Christian Schildknecht, Peter Schillen, Patrick Schindler, Robert Send, Sebastian Valouch, Erwin Thiel, Ingmar Bruder
We present the Focus-Induced Photoresponse (FIP) technique, a novel approach to optical distance measurement. It takes advantage of a universally-observed phenomenon in photodetector devices, an irradiance-dependent responsivity. This means that the output from a sensor is not only dependent on the total flux of incident photons, but also on the size of the area in which they fall. If probe light from an object is cast on the detector through a lens, the sensor response depends on how far in or out of focus the object is...
June 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29907670/the-lectin-pathway-of-complement-activation-in-patients-with-systemic-lupus-erythematosus
#18
Anne Troldborg, Steffen Thiel, Marten Trendelenburg, Justa Friebus-Kardash, Josephine Nehring, Rudi Steffensen, Søren Werner Karlskov Hansen, Magdalena Janina Laska, Bent Deleuran, Jens Christian Jensenius, Anne Voss, Kristian Stengaard-Pedersen
OBJECTIVE: The pathogenesis of systemic lupus erythematosus (SLE) involves complement activation. Activation of complement through the classical pathway (CP) is well established. However, complement activation through pattern recognition not only happens through the CP, but also through the lectin pathway (LP). We investigated the hypothesis that the LP is activated in SLE and involved in the pathogenesis of the disease. METHODS: Using immunoassays developed in-house, we measured concentrations of LP proteins in a cohort of 372 patients with SLE and 170 controls...
June 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29907613/a-modular-dcas9-suntag-dnmt3a-epigenome-editing-system-overcomes-pervasive-off-target-activity-of-direct-fusion-dcas9-dnmt3a-constructs
#19
Christian Pflueger, Dennis Tan, Tessa Swain, Trung Viet Nguyen, Jahnvi Pflueger, Christian Nefzger, Jose M Polo, Ethan Ford, Ryan Lister
DNA methylation is a covalent modification of the genome that plays important roles in genome regulation and vertebrate development. Although detection of this modification in the genome has been possible for several decades, the ability to deliberately and specifically manipulate local DNA methylation states in the genome has been extremely limited. Consequently, this has impeded the direct determination of the consequence of DNA methylation on transcriptional regulation and transcription factor binding in the native chromatin context...
June 15, 2018: Genome Research
https://www.readbyqxmd.com/read/29907596/inflammation-leads-through-pge-ep-3-signaling-to-hdac5-mef2-dependent-transcription-in-cardiac-myocytes
#20
András D Tóth, Richard Schell, Magdolna Lévay, Christiane Vettel, Philipp Theis, Clemens Haslinger, Felix Alban, Stefanie Werhahn, Lina Frischbier, Jutta Krebs-Haupenthal, Dominique Thomas, Hermann-Josef Gröne, Metin Avkiran, Hugo A Katus, Thomas Wieland, Johannes Backs
The myocyte enhancer factor 2 (MEF2) regulates transcription in cardiac myocytes and adverse remodeling of adult hearts. Activators of G protein-coupled receptors (GPCRs) have been reported to activate MEF2, but a comprehensive analysis of GPCR activators that regulate MEF2 has to our knowledge not been performed. Here, we tested several GPCR agonists regarding their ability to activate a MEF2 reporter in neonatal rat ventricular myocytes. The inflammatory mediator prostaglandin E2 (PGE2 ) strongly activated MEF2...
June 15, 2018: EMBO Molecular Medicine
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