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https://www.readbyqxmd.com/read/29224140/whole-genome-bisulfite-sequencing-using-the-ovation%C3%A2-ultralow-methyl-seq-protocol
#1
Christian Daviaud, Victor Renault, Florence Mauger, Jean-François Deleuze, Jörg Tost
The analysis of genome-wide epigenomic alterations including DNA methylation has become a subject of intensive research for many complex diseases. Whole-genome bisulfite sequencing (WGBS) using next-generation sequencing technologies can be considered the gold standard for a comprehensive and quantitative analysis of cytosine methylation throughout the genome. Several approaches including tagmentation- and post bisulfite adaptor tagging (PBAT)-based WGBS have been devised. Here, we provide a detailed protocol based on a commercial kit for the preparation of libraries for WGBS from limited amounts of input DNA (50-100 ng) using the classical approach of WGBS by ligation of methylated adaptors to the fragmented DNA prior to bisulfite conversion...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29224059/lower-complication-rate-and-faster-return-to-sports-in-patients-with-acute-syndesmotic-rupture-treated-with-a-new-knotless-suture-button-device
#2
Christian Colcuc, Marc Blank, Thomas Stein, Florian Raimann, Sanjay Weber-Spickschen, Sebastian Fischer, Reinhard Hoffmann
PURPOSE: Suture button devices for tibiofibular syndesmosis injuries provide semirigid dynamic stabilization, but complications including knot irritation have been reported. No randomized trials of the new knotless suture button devices have been performed. We hypothesized that knotless suture button devices eliminate knot irritation and facilitate quicker return to sports. This study was performed to compare the clinical outcomes, complication rates, and time to return to sports between a new knotless suture button device and syndesmotic screw fixation...
December 9, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29224040/treatment-of-auditory-hallucinations-with-bilateral-theta-burst-stimulation-ctbs-protocol-of-a-randomized-double-blind-placebo-controlled-multicenter-trial
#3
Christian Plewnia, Bettina Brendel, Tobias Schwippel, Peter Martus, Joachim Cordes, Alkomiet Hasan, Andreas J Fallgatter
Auditory verbal hallucinations (AH) are core symptoms of schizophrenia. They are often severely distressing and refractory to therapy. Their perception is associated with increased activity in temporoparietal areas of the brain. Repetitive transcranial magnetic stimulation (rTMS) can reduce focal brain hyperactivity and has been shown to ameliorate AH. However, controlled multicenter clinical trials are still missing, effect sizes are moderate, and the treatment with rTMS is time consuming. Continuous theta burst stimulation (cTBS) is a quicker and potentially more effective technique to reduce cortical hyperactivity...
December 9, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/29224023/negative-symptoms-and-avoidance-of-social-interaction-a-study-of-non-verbal-behaviour
#4
Elizabeth Worswick, Sara Dimic, Christiane Wildgrube, Stefan Priebe
BACKGROUND: Non-verbal behaviour is fundamental to social interaction. Patients with schizophrenia display an expressivity deficit of non-verbal behaviour, exhibiting behaviour that differs from both healthy subjects and patients with different psychiatric diagnoses. The present study aimed to explore the association between non-verbal behaviour and symptom domains, overcoming methodological shortcomings of previous studies. SAMPLING AND METHODS: Standardised interviews with 63 outpatients diagnosed with schizophrenia were videotaped...
December 9, 2017: Psychopathology
https://www.readbyqxmd.com/read/29223977/growth-of-caenorhabditis-elegans-in-defined-media-is-dependent-on-presence-of-particulate-matter
#5
Matthew R Flavel, Adam Mechler, Mahdi Shahmiri, Elizabeth R Mathews, Ashley E Franks, Weisan Chen, Damien Zanker, Bo Xian, Shan Gao, Jing Luo, Surafel Tegegne, Christian Doneski, Markandeya Jois
Caenorhabditis elegans are typically cultured in a monoxenic medium consisting of live bacteria. However, this introduces a secondary organism to experiments and restricts the manipulation of the nutritional environment. Due to the intricate link between genes and environment, greater control and understanding of nutritional factors are required to push the C. elegans field into new areas. For decades, attempts to develop a chemically defined, axenic medium as an alternative for culturing C. elegans have been made...
December 9, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29223914/cannabis-use-disorder-and-male-sex-predict-medical-cannabis-card-status-in-a-sample-of-high-risk-adolescents
#6
Janet Kim, Marilyn E Coors, Susan E Young, Kristen M Raymond, Christian J Hopfer, Tamara L Wall, Robin P Corley, Sandra A Brown, Joseph T Sakai
OBJECTIVE: To examine if a substance use disorder (SUD), especially cannabis use disorder in adolescence, predicts future medical cannabis card status among high-risk youth. METHODS: Data collection occurred in Denver and San Diego. We recruited adolescents, with or at high risk for SUD and conduct problems (hereafter probands) and their siblings (n=654). Baseline (Wave 1) assessments took place between 1999 and 2008, and follow-up (Wave 2) took place between 2010 and 2013...
December 2, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29223729/structure-function-analysis-of-the-c-terminal-domain-of-the-type-vi-secretion-tssb-tail-sheath-subunit
#7
Badreddine Douzi, Laureen Logger, Silvia Spinelli, Stéphanie Blangy, Christian Cambillau, Eric Cascales
The Type VI secretion system (T6SS) is a specialized macromolecular complex dedicated to the delivery of protein effectors into both eukaryotic and bacterial cells. The general mechanism of action of the T6SS is similar to the injection of DNA by contractile bacteriophages. The cytoplasmic portion of the T6SS is evolutionarily, structurally and functionally related to the phage tail complex. It is composed of an inner tube made of stacked Hcp hexameric rings, engulfed within a sheath and built on a baseplate...
December 6, 2017: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29223710/behavioral-responses-of-cd-1-mice-to-conspecific-and-heterospecific-blood-odors-and-to-a-blood-odor-component
#8
Christian Lahger, Matthias Laska
The odor of blood may have both aversive and attractive properties for mammals, depending on the species of the odor donor and the species perceiving the odor. To better understand the informational content of blood odor for a prey species we assessed behavioral responses of male CD-1 mice (n=60) to the odor of blood of same-sex and opposite-sex conspecifics, of a natural predator of mice (cat), and of a herbivore (horse) and an omnivore (human) non-predator of mice. Further, we assessed their behavior towards the mammalian blood odor component trans-4,5-epoxy-(E)-2-decenal which recent studies have shown to be as attractive to mammalian predators as the odor of real blood...
December 6, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/29223662/-discrepancies-and-confluences-in-perception-between-patients-and-nephrologists-of-chronic-kidney-disease-impact-on-vital-impetus-in-adults-not-undergoing-hemodialysis-results-of-the-french-maeva-study
#9
Jean-Philippe Bertocchio, Thierry Baranger, Myriam Isnard-Rouchon, Philippe Zaoui, Christiane Mousson, Gibert Deray
RATIONALE: The impact of chronic kidney disease (CKD) on vital impetus is poorly documented in patients not undergoing renal dialysis and discrepancies can be observed between patients and physicians in perception of QoL and impact of the disease. METHODS: A self-questionnaire was sent to 1282 French nephrologists and a mirrored self-questionnaire was given to patients (CKD stage 3, 4 or 5) by their nephrologist. Data were collected prospectively and anonymously...
December 6, 2017: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/29223646/exploring-the-effects-of-dpp-4-inhibitors-on-the-kidney-from-the-bench-to-clinical-trials
#10
REVIEW
Giuseppe Coppolino, Christian Leporini, Laura Rivoli, Francesco Ursini, Eugenio Donato di Paola, Valeria Cernaro, Franco Arturi, Davide Bolignano, Emilio Russo, Giovambattista De Sarro, Michele Andreucci
Dipeptidyl-peptidase-4 (DPP-4) inhibitors are a relatively new class of non-insulin glucose-lowering agents, belonging to the incretin family, which are able to improve glycemic control with a favorable safety profile, since they are associated with a low risk of hypoglycemia, no weight gain, and good tolerability in patients with chronic renal failure. Some experimental and clinical studies suggest that these drugs may exert significant pleiotropic effects, in particular on chronic kidney disease (CKD) progression, but data from clinical trials are still controversial...
December 6, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29223530/diet-quality-of-chronic-kidney-disease-patients-and-the-impact-of-nutritional-counseling
#11
Andréia Silva Fernandes, Christiane Ishikawa Ramos, Fabiana Baggio Nerbass, Lilian Cuppari
OBJECTIVES: The aims of the study were to evaluate the quality of the diet of nondialysis-dependent patients with chronic kidney disease and to investigate the impact of dietary counseling in the quality of the diet of these patients. METHODS: In the cross-sectional analysis, 3-day food records of 100 nondialysis-dependent patients with chronic kidney disease patients, in the first visit to the renal dietitians, were evaluated using the Diet Quality Index (DQI)...
December 6, 2017: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/29223524/gamma-knife-stereotactic-radiosurgery-for-non-vestibular-cranial-nerve-schwannomas
#12
Anne-Marie Langlois, Christian Iorio-Morin, Laurence Masson-Côté, David Mathieu
BACKGROUND: Non-vestibular cranial schwannomas represent a rare type of benign intracranial tumor. Few studies have evaluated the use of stereotactic radiosurgery (SRS) as a primary management option for these lesions. We therefore performed a retrospective review of our institution's experience focussing on efficacy with regards to tumor control and clinical symptom stabilization, as well as treatment safety. METHODS: Patients were included if they underwent at least one SRS procedure for a non-vestibular schwannoma and had at least 6 months of available imaging follow-up...
December 6, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29223470/reveal-risk-scores-applied-to-riociguat-treated-patients-in-patent-2-impact-of-changes-in-risk-score-on-survival
#13
Raymond L Benza, Harrison W Farber, Adaani Frost, Hossein-Ardeschir Ghofrani, Miguel A Gómez-Sánchez, David Langleben, Stephan Rosenkranz, Dennis Busse, Christian Meier, Sylvia Nikkho, Marius M Hoeper
BACKGROUND: The Registry to Evaluate Early and Long-term PAH Disease Management (REVEAL) risk score (RRS) calculator was developed using data derived from the REVEAL registry, and predicts survival in patients with pulmonary arterial hypertension (PAH) based on multiple patient characteristics. Herein we applied the RRS to a pivotal PAH trial database, the 12-week PATENT-1 and open-label PATENT-2 extension studies of riociguat. We examined the effect of riociguat vs placebo on RRS in PATENT-1, and investigated the prognostic implications of change in RRS during PATENT-1 on long-term outcomes in PATENT-2...
November 11, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29223437/outcomes-in-elderly-and-young-patients-with-st-segment-elevation-myocardial-infarction-undergoing-primary-percutaneous-coronary-intervention-with-bivalirudin-versus-heparin-pooled-analysis-from-the-euromax-and-horizons-ami-trials
#14
Khalid Qaderdan, Gerrit-Jan A Vos, Thomas McAndrew, Philippe Gabriel Steg, Christian W Hamm, Arnoud Van't Hof, Roxana Mehran, Efthymios N Deliargyris, Debra Bernstein, Gregg W Stone, Jurriën M Ten Berg
BACKGROUND: Since older age is a strong predictor of not only bleeding but also of ischemic events, understanding the risk:benefit profile of bivalirudin in the elderly undergoing primary percutaneous coronary intervention (pPCI) for ST-segment elevation (STEMI) is important. For this, we aim to compare elderly with young patients, who all underwent pPCI for STEMI and randomly received either bivalirudin or heparin. METHODS: We performed a patient-level pooled analysis (n=5800) of two large randomized trials...
December 2017: American Heart Journal
https://www.readbyqxmd.com/read/29223425/assessing-age-dependent-multi-task-functional-co-activation-changes-using-measures-of-task-potency
#15
Roselyne J Chauvin, Maarten Mennes, Jan K Buitelaar, Christian F Beckmann
It is being hypothesised that the developing adolescent brain is increasingly enlisting long-range connectivity, allowing improved communication between spatially distant brain regions. The developmental trajectories of such maturational changes remain elusive. Here, we aim to study how the brain engages in multiple tasks (working memory, reward processing, and inhibition) at the network-level and evaluate how effects of age across these tasks are related to each other. We characterise how the brain departs from its functional baseline architecture towards task-induced functional connectivity modulations using a novel measure called task potency, allowing direct comparison between tasks by defining sensitivity to one or multiple tasks...
December 5, 2017: Developmental Cognitive Neuroscience
https://www.readbyqxmd.com/read/29223401/palliative-care-need-and-availability-in-four-referral-hospitals-in-senegal-results-from-a-multi-component-assessment
#16
Hana Hamdi, Oumar Ba, Serigne Niang, Christian Ntizimira, Mouhadou Mbengue, Aminata Sophie Coulbary, Rokhaya Niang, Matthew Parsons, Joseph J Amon, Diederik Lohman
CONTEXT: With prevalence of non-communicable diseases and life expectancy rising in Senegal, the need for palliative care is likely growing. No national palliative care needs assessments have been carried out. OBJECTIVES: To assess the capacity and need for palliative care in Senegal. METHODS: A multi-component assessment of availability and demand for palliative care was conducted in two tertiary and two regional hospitals in Senegal in 2015 with approval from Senegal's National Ethics Committee for Health Research...
December 6, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/29223343/biotic-factors-that-induce-the-tomato-ve1-r-gene
#17
Christian Danve Castroverde, Xin Xu, Ross N Nazar, Jane Robb
In tomato, Verticillium resistance is determined by the Ve gene locus encoding two leucine-rich repeat-receptor-like proteins (Ve1, Ve2). The resistance function usually is attributed to Ve1 alone, with two known alleles: Ve1, encoding a resistance protein, and ve1, with a premature stop codon encoding a truncated product. We have examined further Ve-gene expression in resistant and susceptible near-isolines of Verticillium-infected Craigella tomatoes, using both quantitative RT-PCR and an alternative RFLP assay...
December 2017: Plant Science: An International Journal of Experimental Plant Biology
https://www.readbyqxmd.com/read/29223300/toxocara-species-exposure-symptoms-of-asthma-and-fractional-exhaled-nitric-oxide-in-the-us-population
#18
Funmilola Ogundipe, Edward Christian Anselm Hennis, Alem Mehari, Richard F Gillum
No abstract text is available yet for this article.
December 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29223271/a-woman-admitted-to-the-ed-with-severe-acute-respiratory-failure
#19
Søren Helbo Skaarup, Henrik Bjørnsgaard Madsen, Christian B Laursen
No abstract text is available yet for this article.
December 2017: Chest
https://www.readbyqxmd.com/read/29222763/designing-optimized-production-hosts-by-metabolic-modeling
#20
Christian Jungreuthmayer, Matthias P Gerstl, David A Peña Navarro, Michael Hanscho, David E Ruckerbauer, Jürgen Zanghellini
Many of the complex and expensive production steps in the chemical industry are readily available in living cells. In order to overcome the metabolic limits of these cells, the optimal genetic intervention strategies can be computed by the use of metabolic modeling. Elementary flux mode analysis (EFMA) is an ideal tool for this task, as it does not require defining a cellular objective function. We present two EFMA-based methods to optimize production hosts: (1) the standard approach that can only be used for small and medium scale metabolic networks and (2) the advanced dual system approach that can be utilized to directly compute intervention strategies in a genome-scale metabolic model...
2018: Methods in Molecular Biology
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