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Atrial macrophage

Thomas Beiert, Vedat Tiyerili, Vincent Knappe, Verena Effelsberg, Markus Linhart, Florian Stöckigt, Sabine Klein, Robert Schierwagen, Jonel Trebicka, Georg Nickenig, Jan W Schrickel, René P Andrié
BACKGROUND: Relaxin-2 (RLX) is a peptide hormone that exerts beneficial anti-fibrotic and anti-inflammatory effects in diverse models of cardiovascular disease. The goal of this study was to determine the effects of RLX treatment on the susceptibility to atrial fibrillation (AF) after myocardial infarction (MI). METHODS: Mice with cryoinfarction of the left anterior ventricular wall were treated for two weeks with either RLX (75 μg/kg/d) or vehicle (sodium acetate) delivered via subcutaneously implanted osmotic minipumps...
June 17, 2017: Biochemical and Biophysical Research Communications
Jun Xie, Suhui Zhu, Qing Dai, Jianrong Lu, Jianzhou Chen, Guannan Li, Han Wu, Ran Li, Wei Huang, Biao Xu, Wei Xu
The mechanism underlying thrombosis in atrial fibrillation (AF) is not yet clearly understood. Oncostatin M (OSM), as a member of IL-6 family, is involved in atherosclerosis-mediated thrombosis. The present study hypothesizes that OSM and its downstream factors play a role in thrombogenesis in AF.The specimens of left atrial appendages collected from patients with rheumatic mitral stenosis who underwent valve replacement were divided into 3 groups: sinus rhythm, AF(+)/thrombus(-), and AF(+)/thrombus(+) group...
May 2017: Medicine (Baltimore)
Xin Li, Fang Rao, Chun-Yu Deng, Wei Wei, Fang-Zhou Liu, Hui Yang, Zhao-Yu Wang, Su-Juan Kuang, Xiao-Yan Chen, Yu-Mei Xue, Shu-Lin Wu
Connexin 43 (Cx43) plays an important role in the pathogenesis of atrial fibrillation (AF). The present study sought to investigate the effect of macrophage migration inhibitory factor (MIF), a pleiotropic cytokine, on Cx43 expression and activity and determine the intracellular signaling pathways. Cx43 protein and mRNA levels were assayed using immunofluorescence, real-time PCR, and western blot. We found that increased MIF and extracellular regulated protein kinases (ERK) expression was accompanied by a significant reduction in Cx43 protein expression in atrial tissues from patients with AF compared with those with sinus rhythm...
April 21, 2017: Clinical and Experimental Pharmacology & Physiology
Chunfu Wan, Zhihua Li
OBJECTIVE: Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine secreted by macrophages. This study is performed to investigate whether serum MIF is correlated with atrial fibrillation (AF). METHODS: Totally, 186 AF patients and 103 healthy controls were enrolled in this study. AF patients were then divided into paroxysmal AF, persistent AF, and permanent AF subgroups. RESULTS: There were higher serum MIF concentrations in AF patients than in healthy subjects...
April 13, 2017: Journal of Clinical Laboratory Analysis
Yuko Sonoda, Yasushi Teshima, Ichitaro Abe, Yuki Ebata, Takahiro Oniki, Shintaro Kira, Hidekazu Kondo, Shotaro Saito, Kunio Yufu, Shinji Miyamoto, Tatsuo Shimada, Naohiko Takahashi
No abstract text is available yet for this article.
April 4, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
Rianne Nederlof, Nina C Weber, Nicole P Juffermans, Bas A M J de Mol, Markus W Hollmann, Benedikt Preckel, Coert J Zuurbier
BACKGROUND: Remote ischemic preconditioning (RIPC) efficacy is debated. Possibly, because propofol, which has a RIPC-inhibiting action, is used in most RIPC trials. It has been suggested that clinical efficacy is, however, present with volatile anesthesia in the absence of propofol, although this is based on one phase 1 trial only. Therefore, in the present study we further explore the relation between RIPC and cardioprotection with perioperative anesthesia restricted to sevoflurane and fentanyl, in CABG patients without concomitant procedures...
March 29, 2017: BMC Anesthesiology
Natalia Smorodinova, Martin Bláha, Vojtěch Melenovský, Karolína Rozsívalová, Jaromír Přidal, Mária Ďurišová, Jan Pirk, Josef Kautzner, Tomáš Kučera
BACKGROUND: Atrial fibrillation (AF) is the most common arrhythmia and despite obvious clinical importance remains its pathogenesis only partially explained. A relation between inflammation and AF has been suggested by findings of increased inflammatory markers in AF patients. OBJECTIVE: The goal of this study was to characterize morphologically and functionally CD45-positive inflammatory cell populations in atrial myocardium of patients with AF as compared to sinus rhythm (SR)...
2017: PloS One
Osamu Kume, Yasushi Teshima, Ichitaro Abe, Yuki Ikebe, Takahiro Oniki, Hidekazu Kondo, Shotaro Saito, Akira Fukui, Kunio Yufu, Masahiro Miura, Tatsuo Shimada, Naohiko Takahashi
BACKGROUND: Monocyte chemoattractant protein-1 (MCP-1)-mediated inflammatory mechanisms have been shown to play a crucial role in atrial fibrosis induced by pressure overload. In the present study, we investigated whether left atrial endothelial cells would quickly respond structurally and functionally to pressure overload to trigger atrial fibrosis and fibrillation. METHODS AND RESULTS: Six-week-old male Sprague-Dawley rats underwent suprarenal abdominal aortic constriction (AAC) or a sham operation...
March 2017: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
Mingyi Zhao, Ping Zhu, Masayuki Fujino, Yoshiaki Nishio, Jimei Chen, Hidenori Ito, Kiwamu Takahashi, Motowo Nakajima, Tohru Tanaka, Lingling Zhao, Jian Zhuang, Xiao-Kang Li
BACKGROUND: Hypoxia causes cardiac disease via oxidative stress and mitochondrial dysfunction. 5-Aminolevulinic acid in combination with sodium ferrous citrate (ALA/SFC) has been shown to up-regulate heme oxygenase-1 (HO-1) and decrease macrophage infiltration and renal cell apoptosis in renal ischemia injury mice. However, its underlying mechanism remains largely unknown. The aim of this study was to investigate whether ALA/SFC could protect cardiomyocytes from hypoxia-induced apoptosis by autophagy via HO-1 signaling...
October 28, 2016: Biochemical and Biophysical Research Communications
Zewei Sun, Dongchen Zhou, Xudong Xie, Shuai Wang, Zhen Wang, Wenting Zhao, Hongfei Xu, Liangrong Zheng
Increased macrophage accumulation occurs in the atria of patients with atrial fibrillation (AF). However, the phenotype and functions of the macrophages in AF remain unclear. We investigated the macrophage-atrial myocyte interaction in AF patients and found that the increased macrophages were mainly pro-inflammatory macrophages (iNOS(+), Arg1(-)). Tachypacing of HL-1 atrial myocytes also led to pro-inflammatory macrophage polarization. In addition, lipopolysaccharide (LPS)-stimulated pro-inflammatory macrophages-induced atrial electrical remodeling, evidenced by increased AF incidence and decreased atrial effective refractory period and L-type calcium currents (I Ca-L) in both canine and mouse AF models...
November 2016: Basic Research in Cardiology
Hua Qu, Ke Lin, Hang Wang, Huili Wei, Baolan Ji, Zengsong Yang, Chuan Peng, Xiaoqiu Xiao, Huacong Deng
SCOPE: Diabetic cardiomyopathy is one of the most important cardiac complications associated with diabetes. However, the mechanisms underlying diabetic cardiomyopathy remain unclear. The PARP1, SIRT1, and mTOR pathways have been implicated in cardiac diseases, and they are also associated with diabetes. 1,25(OH)2 D3 was recently recognized as a potential PARP1inhibitor in a macrophage cell line. The aim of our study was to investigate whether 1,25(OH)2 D3 can improve diabetic cardiomyopathy through a vitamin D receptor (VDR)-dependent mechanism associated with the PARP1/SIRT1/mTOR pathway...
May 2017: Molecular Nutrition & Food Research
Xiaoqing Chen, Wuchang Zhang, Qian Wang, Lili Du, Yi Yi, Yan Liu, Xu Liu, Shengzhong Duan
The purpose of the present study was to study the impacts of eplerenone (EPL), an antagonist of mineralocorticoid receptors (MR), on atrial fibrosis in a mouse model with selective fibrosis in the atrium, and to explore the possible mechanisms. Using mutant TGF-β1 transgenic (Tx) mice, we first demonstrated that EPL inhibited atrial fibrosis specifically and decreased macrophage accumulation in the atria of these mice. Results from immunohistochemistry and western blotting showed that EPL attenuated protein expression of fibrosis-related molecules such as connective tissue growth factor (CTGF) and fibronectin in the atria of Tx mice...
October 2016: Science China. Life Sciences
Mark Pv Begieneman, Reindert W Emmens, Liza Rijvers, Linde Woudstra, Walter J Paulus, Bela Kubat, Alexander Ba Vonk, Albert C van Rossum, Diana Wouters, Sacha Zeerleder, Marieke van Ham, Casper G Schalkwijk, Hans Wm Niessen, Paul Aj Krijnen
AIMS: Inflammation plays an important role in the pathogenesis of myocardial infarction (MI). Whether MI induces atrial inflammation is unknown however. Here, we analysed atrial inflammation in patients with MI and in rats with experimentally induced MI. The effect of the anti-inflammatory agent C1-esterase inhibitor (C1inh) on atrial inflammation in rats was also analysed. METHODS: In the hearts of patients who died at different time points after MI (total n=24, mean age=60), neutrophils (myeloperoxidase-positive cells), lymphocytes (CD45-positive cells) and macrophages (CD68-positive cells) were quantified in the myocardium of the left and right atria and the infarcted left and non-infarcted right ventricles and compared with control patients (n=5, mean age=59)...
December 2016: Journal of Clinical Pathology
Alberto Roghi, Erika Poggiali, Elena Cassinerio, Patrizia Pedrotti, Marianna Giuditta, Angela Milazzo, Giuseppina Quattrocchi, Maria Domenica Cappellini
BACKGROUND: Type 1 Gaucher disease (GD1) is the most common lysosomal disorder, characterized by the accumulation of beta-glucocerebroside into the macrophages of several organs. Cardiac involvement is rare and referred to as restrictive cardiomyopathy, pulmonary hypertension, and calcifications of the valves and the aortic arch. AIM: To assess the cardiovascular status by cardiac magnetic resonance, including evaluation of tissue characterization, in GD1 patients...
June 30, 2016: Journal of Cardiovascular Medicine
Kenshi Uemura, Hidekazu Kondo, Yumi Ishii, Mami Kobukata, Miho Haraguchi, Takaaki Imamura, Toyokazu Otsubo, Yuki Ikebe-Ebata, Ichitaro Abe, Reika Ayabe, Shotaro Saito, Kohei Aoki, Yasuko Nagano-Torigoe, Hidefumi Akioka, Tetsuji Shinohara, Yasushi Teshima, Takayuki Masaki, Kunio Yufu, Mikiko Nakagawa, Naohiko Takahashi
BACKGROUND AND OBJECTIVES: Recently, it was reported that mast cells (MCs) could underlie the mechanisms of several cardiovascular diseases. However, the role of MCs in diabetes-induced atrial fibrillation (AF) has not been notably investigated. We tested the hypothesis that MC deficiency attenuates hyperglycemia-induced AF in mice. METHODS AND RESULTS: Mast cell-deficient W/W(v)  mice, and congenic +/+ littermates (WT) were divided into either the vehicle (VEH)-injection group or the streptozotocin (STZ)-injection group (MCKO-VEH, MCKO-STZ, WT-VEH, and WT-STZ groups)...
August 2016: Journal of Cardiovascular Electrophysiology
Mikio Shiba, Yasuo Sugano, Yoshihiko Ikeda, Hatsue Ishibashi-Ueda, Takahiro Ohara, Takuya Hasegawa, Hideaki Kanzaki, Toshihisa Anzai
A 74-year-old man, who had a history of a mitral valve replacement for rheumatic heart disease (RHD) 30 years previously, was admitted with progressive heart failure. Massive calcification was observed around the left atrium on multidetector CT, in addition to a late gadolinium enhancement (LGE)-positive layer adjacently outside of the calcification on MRI. He underwent a second mitral valve replacement for the prosthetic valve failure. Pathohistological analyses of a tissue section of the left atrial wall from a surgical specimen revealed lymphocyte and macrophage infiltration that coincided with the LGE-positive layer on MRI, suggesting the existence of sustained active inflammation even after the long period of RHD...
2016: Internal Medicine
Qihai David Gu, Charles R Moss, Kristen L Kettelhut, Carolyn A Gilbert, Hongzhen Hu
Transient receptor potential vanilloid receptor 4 (TRPV4) is a calcium-permeable non-selective cation channel implicated in numerous physiological and pathological functions. This study aimed to investigate the effect of TRPV4 activation on respiration and to explore the potential involvement of bronchopulmonary sensory neurons. Potent TRPV4 agonist GSK1016790A was injected into right atrium in anesthetized spontaneously breathing rats and the changes in breathing were measured. Patch-clamp recording was performed to investigate the effect of GSK1016790A or another TRPV4 activator 4α-PDD on cultured rat vagal bronchopulmonary sensory neurons...
2016: Frontiers in Physiology
Olga Frunza, Ilaria Russo, Amit Saxena, Arti V Shinde, Claudio Humeres, Waqas Hanif, Vikrant Rai, Ya Su, Nikolaos G Frangogiannis
The β-galactoside-binding animal lectin galectin-3 is predominantly expressed by activated macrophages and is a promising biomarker for patients with heart failure. Galectin-3 regulates inflammatory and fibrotic responses; however, its role in cardiac remodeling remains unclear. We hypothesized that galectin-3 may be up-regulated in the pressure-overloaded myocardium and regulate hypertrophy and fibrosis. In normal mouse myocardium, galectin-3 was constitutively expressed in macrophages and was localized in atrial but not ventricular cardiomyocytes...
May 2016: American Journal of Pathology
Guixin He, Wei Tan, Bingjian Wang, Jianzhou Chen, Guannan Li, Suhui Zhu, Jun Xie, Biao Xu
Atrial fibrillation (AF) is the most common arrhythmia. In patients with AF, the role of macrophage subsets in thrombogenesis is unclear. In the present study, we analyzed the role of M1 and M2 macrophages and related cytokines in thrombogenesis of AF. Immunohistochemistry, Western blot, and TUNEL assay were used to detect M1/M2 macrophage infiltration, the expression pattern of IL-1β and inflammasome components, and apoptosis of cardiomyocytes in 71 specimens obtained from the left atrial appendage of patients with rheumatic mitral stenosis (MS) with or without thrombosis...
2016: PloS One
Jussi V Leinonen, Avishag Korkus-Emanuelov, Yochai Wolf, Michal Milgrom-Hoffman, David Lichtstein, Sara Hoss, Chaim Lotan, Eldad Tzahor, Steffen Jung, Ronen Beeri
BACKGROUND: The developmental origin of the c-kit expressing progenitor cell pool in the adult heart has remained elusive. Recently, it has been discovered that the injured heart is enriched with c-kit(+) cells, which also express the hematopoietic marker CD45. METHODS AND RESULTS: In this study, we characterize the phenotype and transcriptome of the c-kit+/CD45+/CD11b+/Flk-1+/Sca-1±(B-type) cell population, originating from the left atrial appendage. These cells are defined as cardiac macrophage progenitors...
April 15, 2016: International Journal of Cardiology
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