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https://www.readbyqxmd.com/read/29332649/isoniazid-and-rifampicin-heteroresistant-mycobacterium-tuberculosis-isolated-from-tuberculous-meningitis-patients-in-india
#1
Renu Gupta, Rajeev Thakur, Suman Kushwaha, Nupur Jalan, Pumanshi Rawat, Piyush Gupta, Amitesh Aggarwal, Meena Gupta, Vikas Manchanda
BACKGROUND: Heteroresistant Mycobacterium tuberculosis (mixture of susceptible and resistant subpopulations) is thought to be a preliminary stage to full resistance and timely detection, initiation of correct treatment is vital for successful anti tubercular therapy. The aim of this study was to detect multi drug resistant (MDR) and heteroresistant M. tuberculosis with the associated gene mutations from patients of tuberculous meningitis. METHODS: A total of 197 M...
January 2018: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/29326000/epidemiology-of-tuberculosis-in-spain-results-obtained-by-the-national-epidemiological-surveillance-network-in-2015
#2
Rosa Cano-Portero, Rocío Amillategui-Dos Santos, Raquel Boix-Martínez, Amparo Larrauri-Cámara
The epidemiological surveillance data for tuberculosis in Spain in 2015 is analysed in this report. This information was gathered through cases reported to the Red Nacional de Vigilancia Epidemiológica [National Epidemiological Surveillance Network]. In addition, the update of the treatment of the cases reported in 2014 is included. The incidence rate of tuberculosis in 2015 was 10.59 cases per 100,000 inhabitants, 10% less than in 2014. This decrease was mainly due to the sustained decreased trend of pulmonary tuberculosis rates, from other locations and in adults, while for cases of tuberculous meningitis and in children the decrease is less marked, with a tendency to stabilization...
January 8, 2018: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/29322063/neurological-sequelae-of-adult-meningitis-in-africa-a-systematic-literature-review
#3
REVIEW
Drew W Goldberg, Mark W Tenforde, Hannah K Mitchell, Joseph N Jarvis
The high human immunodeficiency virus (HIV) prevalence in sub-Saharan Africa has markedly changed the epidemiology and presentation of adult meningitis. We conducted a systematic review using PubMed, Embase, Ovid, CENTRAL, and African Index Medicus to identify studies in Africa with data on neurological outcomes in adults after meningitis. We found 22 articles meeting inclusion criteria. From 4 studies with predominately pneumococcal meningitis, a median of 19% of survivors experienced hearing loss up to 40 days...
January 2018: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29251339/-extramedullary-intradural-tuberculosis-a-case-report-and-review-of-the-literature
#4
D Quispe, M Alvarado, D Rivas, I Gonzales
INTRODUCTION: Central nervous system tuberculosis is a common chronic infection in developing countries, being the most frequent forms: tuberculous meningitis and intracranial tuberculosis. Extramedullary intradural tuberculosis is a rare entity with few cases described in the world literature, and is usually associated with a history of tuberculous meningitis or during antituberculosis treatment. CASE REPORT: A 17 years-old male patient, without history of tuberculosis, with subacute onset and progressive course of compressive myelopathy...
January 1, 2018: Revista de Neurologia
https://www.readbyqxmd.com/read/29245963/identification-of-potential-metabolic-biomarkers-of-cerebrospinal-fluids-that-differentiate-tuberculous-meningitis-from-other-types-of-meningitis-by-a-metabolomics-study
#5
Yi-Ning Dai, Hai-Jun Huang, Wen-Yuan Song, Yong-Xi Tong, Dan-Hong Yang, Ming-Shan Wang, Yi-Cheng Huang, Mei-Juan Chen, Jia-Jie Zhang, Ze-Ze Ren, Wei Zheng, Hong-Ying Pan
Tuberculous meningitis (TBM) is caused by tuberculosis infection of of the meninges, which are the membrane systems that encircle the brain, with a high morbidity and mortality rate. It is challenging to diagnose TBM among other types of meningitis, such as viral meningitis, bacterial meningitis and cryptococcal meningitis. We aimed to identify metabolites that are differentially expressed between TBM and the other types of meningitis by a global metabolomics analysis. The cerebrospinal fluids (CSF) from 50 patients with TBM, 17 with viral meningitis, 17 with bacterial meningitis, and 16 with cryptococcal meningitis were analyzed using ultra high performance liquid chromatography coupled with quadrupole time of flight mass spectrometry (UHPLC-QTOF-MS)...
November 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/29228220/the-burden-of-presumed-tuberculosis-in-hospitalized-children-in-a-resource-limited-setting-in-papua-new-guinea-a-prospective-observational-study
#6
Villa Watch, Jimmy Aipit, Tina Kote-Yarong, Allanie Rero, John W Bolnga, Elvin Lufele, Moses Laman
Background: In Papua New Guinea, TB is considered to be a major public health problem, but little is known about the prevalence and prognosis of presumed TB in children. Methods: As part of a prospective hospital-based surveillance on the northern coast of mainland Papua New Guinea, the authors investigated the admission prevalence and case fatality rate associated with presumed TB over a 6-year period (2011-2016). All children admitted who were diagnosed with TB were followed-up until discharge or death...
December 8, 2017: International Health
https://www.readbyqxmd.com/read/29226732/pharmacokinetics-and-pharmacogenetics-of-anti-tubercular-drugs-a-tool-for-treatment-optimization
#7
Ilaria Motta, Andrea Calcagno, Stefano Bonora
WHO global strategy is to end tuberculosis epidemic by 2035. Pharmacokinetic and pharmacogenetic studies are increasingly performed and might confirm their potential role in optimizing treatment outcome in specific settings and populations. Insufficient drug exposure seems to be a relevant factor in tuberculosis outcome and for the risk of phenotypic resistance. Areas covered: This review discusses available pharmacokinetic and pharmacogenetic data of first and second-line antitubercular agents in relation to efficacy and toxicity...
January 2018: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/29201438/pathomorphological-peculiarities-of-tuberculous-meningoencephalitis-associated-with-hiv-infection
#8
Volodymyr M Kozko, Andriy V Bondarenko, Anatoliy V Gavrylov, Olga S Shevchenko, Vitalii V Gargin
Background and aims: One of the most severe manifestation displays of tuberculosis (TB) generalization is meningitis/meningoencephalitis. The purpose of this work was to improve the diagnostic efficiency of TB central nervous system (CNS) affection in human immunodeficiency virus (HIV)-infected persons. Materials and methods: Meninges and cerebral tissues, taken from died patients, who were HIV-infected and dead from TB of CNS affection, were investigated histologically...
September 2017: Interventional Medicine & Applied Science
https://www.readbyqxmd.com/read/29184338/rapid-clinical-score-for-the-diagnosis-of-tuberculous-meningitis-a-retrospective-cohort-study
#9
Raluca Jipa, Ioana D Olaru, Eliza Manea, Simona Merisor, Adriana Hristea
Objective: The aim of our study was to retrospectively validate a previously described rapid clinical score (RCS) in distinguishing tuberculous meningitis (TBM) from viral meningitis (VM) in people who are at increased risk of tuberculosis, as well as from cryptococcal meningitis (CM) in HIV-infected patients. Methods: We performed a retrospective study of patients admitted with a diagnosis of aseptic meningitis between January 2012 and December 2015, to a referral hospital for infectious diseases...
October 2017: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/29160524/a-fatal-case-of-tuberculous-meningitis-in-a-child-with-juvenile-idiopathic-arthritis-a-diagnostic-challenge
#10
Zumrut Sahbudak Bal, Pinar Yazici, Semra Sen, Cenk Eraslan, Cengiz Cavusoglu, Bulent Karapinar, Fadil Vardar
The prognosis of tuberculous meningitis, a rare form of extrapulmonary tuberculosis, depends on the stage of treatment initiation. We report a fatal case of tuberculous meningitis. The patient had received successive tumor necrosis factor (TNF) antagonists and abatacept to treat juvenile idiopathic arthritis, with negative results for polymerase chain reaction and acid-fast bacilli on smear, had normal cerebrospinal fluid (CSF) adenosine deaminase and glucose levels. Six weeks post-admission, the CSF culture demonstrated Mycobacterium tuberculosis...
September 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29142521/fatal-infections-in-older-patients-with-inflammatory-bowel-disease-on-anti-tumor-necrosis-factor-therapy
#11
Way-Seah Lee, Najib Azmi, Ruey-Terng Ng, Sik-Yong Ong, Sasheela Sri La Ponnampalavanar, Sanjiv Mahadeva, Ida Hilmi
Anti-tumor necrosis factor (anti-TNF) is highly effective in inflammatory bowel disease (IBD); however, it is associated with an increased risk of infections, particularly in older adults. We reviewed 349 patients with IBD, who were observed over a 12-month period, 74 of whom had received anti-TNF therapy (71 patients were aged <60 years and 3 were aged ≥60 years). All the 3 older patients developed serious infectious complications after receiving anti-TNFs, although all of them were also on concomitant immunosuppressive therapy...
October 2017: Intestinal Research
https://www.readbyqxmd.com/read/29140996/childhood-tuberculosis-is-associated-with-decreased-abundance-of-t-cell-gene-transcripts-and-impaired-t-cell-function
#12
Cheryl Hemingway, Maurice Berk, Suzanne T Anderson, Victoria J Wright, Shea Hamilton, Hariklia Eleftherohorinou, Myrsini Kaforou, Greg M Goldgof, Katy Hickman, Beate Kampmann, Johan Schoeman, Brian Eley, David Beatty, Sandra Pienaar, Mark P Nicol, Michael J Griffiths, Simon J Waddell, Sandra M Newton, Lachlan J Coin, David A Relman, Giovanni Montana, Michael Levin
The WHO estimates around a million children contract tuberculosis (TB) annually with over 80 000 deaths from dissemination of infection outside of the lungs. The insidious onset and association with skin test anergy suggests failure of the immune system to both recognise and respond to infection. To understand the immune mechanisms, we studied genome-wide whole blood RNA expression in children with TB meningitis (TBM). Findings were validated in a second cohort of children with TBM and pulmonary TB (PTB), and functional T-cell responses studied in a third cohort of children with TBM, other extrapulmonary TB (EPTB) and PTB...
2017: PloS One
https://www.readbyqxmd.com/read/29084241/novel-approach-based-on-one-tube-nested-pcr-and-a-lateral-flow-strip-for-highly-sensitive-diagnosis-of-tuberculous-meningitis
#13
Yajuan Sun, Jiajun Chen, Jia Li, Yawei Xu, Hui Jin, Na Xu, Rui Yin, Guohua Hu
Rapid and sensitive detection of Mycobacterium tuberculosis (M. Tb) in cerebrospinal fluid is crucial in the diagnosis of tuberculous meningitis (TBM), but conventional diagnostic technologies have limited sensitivity and specificity or are time-consuming. In this work, a novel, highly sensitive molecular diagnostic method, one-tube nested PCR-lateral flow strip test (OTNPCR-LFST), was developed for detecting M. tuberculosis. This one-tube nested PCR maintains the sensitivity of conventional two-step nested PCR and reduces both the chance of cross-contamination and the time required for analysis...
2017: PloS One
https://www.readbyqxmd.com/read/29082052/meningeal-tb-in-a-39-year-old-male-presenting-with-headache
#14
Jason Selinger, Thar El Baage
Meningeal tuberculosis is rare in the developed world, with only 92 cases of meningeal TB reported in the United States in 2014 according to the CDC (CDC, 2015). We describe the case of a 39-year-old male with a history of alcohol abuse, whose cerebral spinal fluid acid fast smears confirmed TB only weeks after his death. His only initial presenting symptom was headache, and his condition declined rapidly during his hospitalization.
2017: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/29062710/brucellosis-a-cause-of-meningitis-not-to-neglect
#15
Abdelhay Lemnouer, Mohammed Frikh, Adil Maleb, Aziz Ahizoune, Ahmed Bourazza, Mostafa Elouennass
Brucellosis is the most frequent bacteria zoonosis in the world, with more than half a million new cases each year [1]. It is also the most significant zoonos in the edge of the Mediterranean Sea [2]. This zoonosis is capable of affecting humans and cause polymorphic clinical manifestations. In Morocco, the southern regions are the main affected areas [3]. We are reporting the observation of a 17-year-old male patient, who presented a febrile meningeal syndrome for 9 months without sensitivo-motor deficit. Tuberculosis is frequently evoked in such clinical presentations because Morocco is an endemic country, brucellosis is therefore often forgotten...
2017: IDCases
https://www.readbyqxmd.com/read/29033887/atypical-cerebral-manifestations-of-disseminated-mycobacterium-tuberculosis
#16
Ji Hye Hwang, Kyung Mi Lee, Ji Eun Park, Hyug-Gi Kim, Eui Jong Kim, Woo Suk Choi, Na Rae Yang
BACKGROUND: We investigated the patterns of cerebral manifestations in patients with underlying pulmonary or extrapulmonary tuberculosis or disseminated tuberculosis. MATERIALS AND METHODS: From January 2010 to September 2016, brain magnetic resonance imaging (MRI) scans were obtained to evaluate cerebral manifestations in patients with underlying pulmonary or extrapulmonary tuberculosis. We also included patients with drug-resistant tuberculosis or disseminated tuberculosis...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29029055/prognostic-models-for-9-month-mortality-in-tuberculous-meningitis
#17
Le Thi Phuong Thao, A Dorothee Heemskerk, Ronald B Geskus, Nguyen Thi Hoang Mai, Dang Thi Minh Ha, Tran Thi Hong Chau, Nguyen Hoan Phu, Nguyen Van Vinh Chau, Maxine Caws, Nguyen Huu Lan, Do Dang Anh Thu, Nguyen Thuy Thuong Thuong, Jeremy Day, Jeremy J Farrar, M Estee Torok, Nguyen Duc Bang, Guy E Thwaites, Marcel Wolbers
Background: Tuberculous meningitis (TBM) is the most severe form of extra-pulmonary tuberculosis. We developed and validated prognostic models for 9-month mortality in HIV-uninfected and HIV-infected adults with TBM. Methods: We included 1699 subjects from four randomized clinical trials and one prospective observational study conducted at two major referral hospitals in Southern Vietnam from 2001-2015. Modelling was based on multivariable Cox proportional hazards regression...
September 26, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29021660/18f-fludeoxyglucose-positron-emission-tomography-computed-tomography-guided-diagnosis-of-prostatic-and-leptomeningeal-tuberculosis
#18
Madhuri Shimpi Mahajan, Akshay Bedmutha, Natasha Singh
Genitourinary tuberculosis contributes to 10%-14% of extrapulmonary TB. Prostate tuberculosis is rare and usually found incidentally following transurethral resection of the prostate for benign prostatic hyperplasia. We report a case of an immunocompetent patient with pyrexia of unknown origin, on evaluation with whole-body 18F-fludeoxyglucose positron emission tomography computed tomography scan found to have suspicious prostatic primary, with hypermetabolic abnormalities involving the brain. Histopathological diagnosis was established as multifocal tuberculosis involving prostate, meninges, and intracranial tuberculomas...
October 2017: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/29018323/cerebrospinal-fluid-amino-acid-profiling-of-pediatric-cases-with-tuberculous-meningitis
#19
Shayne Mason, Carolus J Reinecke, Regan Solomons
Background: In Africa, tuberculosis is generally regarded as persisting as one of the most devastating infectious diseases. The pediatric population is particularly vulnerable, with infection of the brain in the form of tuberculous meningitis (TBM) being the most severe manifestation. TBM is often difficult to diagnose in its early stages because of its non-specific clinical presentation. Of particular concern is that late diagnosis, and subsequent delayed treatment, leads to high risk of long-term neurological sequelae, and even death...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28975470/infections-of-the-central-nervous-system-in-returning-travelers-and-immigrants
#20
REVIEW
Haley Thompson, Kiran Thakur
PURPOSE OF REVIEW: This review highlights current knowledge in travel-related neuroinfectious diseases, providing insight on approaches to prevention, diagnosis, and treatment of infections of the central nervous system (CNS) in travelers and immigrants. RECENT FINDINGS: Updates on travel vaccine recommendations including vaccine-specific interactions with immunosuppressive agents, advances in Zika virus and dengue virus vaccine development, new diagnostic criteria for neurocysticercosis, updates on treatment approaches for tuberculosis meningitis...
October 3, 2017: Current Infectious Disease Reports
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