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https://www.readbyqxmd.com/read/28737579/prostate-specific-membrane-antigen-targeted-imaging-with-18f-dcfpyl-in-high-grade-gliomas
#1
Roberto Andres Salas Fragomeni, Joshua R Menke, Matthias Holdhoff, Clare Ferrigno, John Joseph Laterra, Lilja B Solnes, Mehrbod S Javadi, Zsolt Szabo, Martin G Pomper, Steven P Rowe
High-grade gliomas (World Health Organization grade III-IV) are highly lethal primary brain tumors. Imaging modalities, including MRI and FDG PET, provide a limited ability to differentiate treatment effects (such as radiation necrosis) from recurrent or residual tumor. As the first step in validating the applicability of prostate-specific membrane antigen (PSMA)-targeted imaging in high-grade gliomas, we evaluated the ability of the PSMA-targeted small molecule [F]DCFPyL (2-(3-(1carboxy-5-(6-[F]fluoro-pyridine-3-carbonyl)-amino]-pentyl)-ureido)-pentanedioic acid) to image high-grade gliomas in a series of 3 prospectively recruited patients...
July 22, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28737577/vertebral-myeloma-mimicking-prostatic-carcinoma-metastasis-in-68ga-psma-pet-ct
#2
Esben Hoej Merrild, Steen Baerentzen, Kirsten Bouchelouche, Simon Buus
Ga-PSMA PET/CT was performed in a 75-year-old man with newly diagnosed prostate cancer because of an equivocal lesion in the spine both on Tc-bone-SPECT/CT and MRI. Because of increased PSMA activity on PET/CT, the bone lesion was interpreted as metastasis from prostate cancer. Later, the patient was diagnosed as having monoclonal gammopathy of unknown significance. A biopsy was performed, and histological examination revealed multiple myeloma with PSMA expression in the neovessels but no metastatic prostate cancer cells...
July 22, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28736746/malakoplakia-of-the-prostate-as-a-mimicker-of-prostate-cancer-on-prostate-health-index-and-magnetic-resonance-imaging-fusion-prostate-biopsy-a-case-report
#3
Nathaniel H Heah, Teck Wei Tan, Yung Khan Tan
Background: Isolated malakoplakia of the prostate is a rare inflammatory condition that has been clinically mistaken for prostatic malignancies. The development of Prostate Imaging Reporting and Data System (PI-RADS) classifications, and Prostate Health Index (PHI) has led to more accurate diagnosis of clinically significant disease and stratification of patients that may be at risk of prostate cancer. Case Presentation: We present a case of a 75-year-old male who was on follow-up with our hospital for elevated prostate specific antigen (PSA)...
2017: Journal of Endourology Case Reports
https://www.readbyqxmd.com/read/28736321/an-intraprostatic-modified-release-formulation-of-antiandrogen-2-hydroxyflutamide-for-localized-prostate-cancer
#4
T L Tammela, M Häggman, S Ladjevardi, K Taari, T Isotalo, H Lennernäs, J Weis, C von Below, C Wassberg, B Lennernäs, A Tolf, N Axén, C-G Gölander, H Ahlström
PURPOSE: To investigate tolerability, safety and antitumor effects of a novel intra-prostatic depot formulation of antiandrogen 2-hydroxyflutamide (2-HOF in NanoZolid(®)) in men with localized prostate cancer (PCa). MATERIALS AND METHODS: Two clinical trials, LPC-002 and LPC-003, were conducted on a total of 47 men. The formulation was injected transrectally into the prostate with ultrasound guidance. In LPC-002 the effects on prostate specific antigen (PSA) and prostate volume (PV) were measured over 6 months on 24 patients...
July 20, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28735018/safety-and-feasibility-of-direct-mri-guided-transperineal-prostate-biopsy-using-a-novel-mri-safe-robotic-device
#5
Mark W Ball, Ashley E Ross, Kamyar Ghabili, Chunwoo Kim, Changhan Jun, Doru Petrisor, Li Pan, Jonathan I Epstein, Katarzyna J Macura, Dan S Stoianovici, Mohamad E Allaf
OBJECTIVE: To evaluate safety and feasibility in a first in human trial of direct MRI-guided prostate biopsy using a novel robotic device. METHODS: MrBot is an MRI-safe robotic device constructed entirely of nonconductive, nonmetallic, and nonmagnetic materials, developed by our group. A safety and feasibility clinical trial was designed to assess the safety and feasibility of direct MRI-guided biopsy with MrBot and determine its targeting accuracy. Men with elevated PSA, prior negative prostate biopsy and cancer suspicious region (CSR) on MRI were enrolled in the study...
July 19, 2017: Urology
https://www.readbyqxmd.com/read/28733200/hypothermic-cooling-measured-by-thermal-mri-imaging-feasibility-and-implications-for-virtual-imaging-in-the-urogenital-pelvis
#6
Douglas Skarecky, Hon Yu, Jennifer Linehan, Blanca Morales, Min-Ying Su, Peter Fwu, Thomas Ahlering
OBJECTIVE: To study the combination of thermal MRI imaging and novel hypothermic cooling, via an Endorectal Cooling Balloon (ECB) to assess the effective dispersion and temperature drop in pelvic tissue to potentially reduce inflammatory cascade in surgical applications. METHODS: Three male subjects, prior to undergoing robot-assisted radical prostatectomy (RARP), were cooled via an ECB, rendered MRI compatible by for patient safety Prior to ECB hypothermia. MRI studies were performed using a 3T scanner and included T2w anatomical scan for the pelvic structures, followed by a temperature mapping scan...
July 18, 2017: Urology
https://www.readbyqxmd.com/read/28728994/a-comprehensive-analysis-of-cribriform-morphology-on-mr-us-fusion-biopsy-correlated-with-radical-prostatectomy-specimens
#7
Matthew Truong, Changyong Feng, Gary Hollenberg, Eric Weinberg, Edward M Messing, Hiroshi Miyamoto, Thomas P Frye
PURPOSE: Recently, a large body of evidence has emerged recognizing that cribriform morphology is an aggressive prostate cancer morphological pattern associated with higher cancer-specific mortality. In a comprehensive analysis, we compared traditional and contemporary prostate biopsy techniques for detection of prostate cancer with cribriform morphology and used radical prostatectomy as a reference standard. MATERIALS AND METHODS: A retrospectively maintained single institution multiparametric MRI (mpMRI) database (n = 1,001) was queried to identify 240 patients who underwent MR/US fusion targeted biopsy (TB) and concurrent systematic biopsy (SB) from December 2014 to December 2016...
July 17, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28728993/value-of-tracking-biopsy-in-men-undergoing-active-surveillance-of-prostate-cancer
#8
Edward Chang, Tonye A Jones, Shyam Natarajan, Devi Sharma, Demetrios Simopoulos, Daniel J Margolis, Jiaoti Huang, Frederick J Dorey, Leonard S Marks
PURPOSE: To compare the upgrading rate obtained by re-sampling precise spots of prostate cancer (tracking biopsy) vs conventional systematic re-sampling, during follow-up of; men in active surveillance. MATERIALS AND METHODS: Subjects were all 352 men, from 2009 to 2017, with Gleason 3+3 (n=268) or Gleason 3+4 (n=84) prostate cancer at initial MRI/ultrasound fusion biopsy and who subsequently had a second fusion biopsy. At first biopsy session, all men underwent 12-core systematic biopsies and, when MRI-visible lesions were present, targeted biopsies...
July 17, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28725608/from-promis-to-pro-mri-in-primary-prostate-cancer-diagnosis
#9
EDITORIAL
Ivo G Schoots, Monique J Roobol
No abstract text is available yet for this article.
June 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28725592/is-contrast-enhancement-needed-for-diagnostic-prostate-mri
#10
REVIEW
Michele Scialpi, Valeria Rondoni, Maria Cristina Aisa, Eugenio Martorana, Alfredo D'Andrea, Corrado Maria Malaspina, Agostino Orlandi, Giorgio Galassi, Emanuele Orlandi, Pietro Scialpi, Michele Dragone, Diego Palladino, Annalisa Simeone, Michele Amenta, Giampaolo Bianchi
Prostate Imaging Reporting and Data System version 2 (PI-RADS v2) provides clinical guidelines for multiparametric magnetic resonance imaging (mpMRI) [T2-weighted imaging (T2WI), diffusion-weighted imaging (DWI) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI)] of prostate. However, DCE-MRI seems to show a limited contribution in prostate cancer (PCa) detection and management. In our experience, DCE-MRI, did not show significant change in diagnostic performance in addition to DWI and T2WI [biparametric MRI (bpMRI)] which represent the predominant sequences to detect suspected lesions in peripheral and transitional zone (TZ)...
June 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28725591/diffusion-weighted-imaging-of-the-prostate-principles-application-and-advances
#11
REVIEW
Martin H Maurer, Johannes T Heverhagen
This review article aims to provide an overview on the principles of diffusion-weighted magnetic resonance imaging (DW-MRI) and its applications in the imaging of the prostate. DW-MRI with regards to different applications for prostate cancer (PCa) detection and characterization, local staging as well as for active surveillance (AS) and tumor recurrence after radical prostatectomy (RP) will be discussed. Furthermore, advances in DW-MRI techniques like diffusion kurtosis imaging (DKI) will be presented.
June 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28725590/mri-fusion-biopsy-the-contemporary-experience
#12
REVIEW
Marc A Bjurlin, Andrew B Rosenkrantz, Samir S Taneja
Advancements in magnetic resonance imaging (MRI) and MRI-ultrasound (US)-fusion targeted biopsy have resulted in a paradigm shift in the diagnosis of prostate cancer by overcoming the limitations of systematic biopsy. Prebiopsy MRI and MRI-US-fusion biopsy results in an increased detection of clinically significant disease, reduction in the detection of indolent disease, and allows for tumor localization during targeted biopsy. With these advantages, we have adopted a prebiopsy MRI and MRI-US-fusion biopsy diagnostic care pathway for all men at risk for prostate cancer and have performed more than 1900 biopsies to date...
June 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28725589/multi-parametric-magnetic-resonance-imaging-as-a-management-decision-tool
#13
REVIEW
David C Johnson, Robert E Reiter
The ability to image the prostate accurately and better characterize cancerous lesions makes multiparametric magnetic resonance imaging (mpMRI) an invaluable tool to improve management of localized prostate cancer (PCa). Improved risk stratification is warranted given the evidence of significant overtreatment of indolent PCa. mpMRI can more accurately rule out clinically significant PCa in men deciding between surveillance and definitive treatment to reduce overtreatment. mpMRI improves detection of clinically significant PCa, which helps minimize sampling error, a major limitation of the traditional diagnostic paradigm...
June 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28725588/role-of-mpmri-of-the-prostate-in-screening-for-prostate-cancer
#14
REVIEW
Christopher J D Wallis, Masoom A Haider, Robert K Nam
Prostate cancer screening offers the opportunity to significantly reduce morbidity and mortality from this disease. Currently, serum prostate-specific antigen (PSA) testing is the most widely used screening modality. However, PSA testing continues to have low positive and negative predictive value leading to unnecessary invasive prostate biopsy while missing patients with aggressive forms of the disease. Magnetic resonance imaging (MRI) has been gaining an increasingly large role in the management of patients with early stage prostate cancer including diagnosis in patients with abnormal PSA levels, monitoring of patients on active surveillance, and staging prior to definitive interventions...
June 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28725587/multi-parametric-mri-imaging-of-the-prostate-implications-for-focal-therapy
#15
REVIEW
James S Wysock, Herbert Lepor
The primary goal of a focal therapy treatment paradigm is to achieve cancer control through targeted tissue destruction while simultaneously limiting deleterious effects on peri-prostatic structures. Focal therapy approaches are employed in several oncologic treatment protocols, and have been shown to provide equivalent cancer control for malignancies such as breast cancer and renal cell carcinoma. Efforts to develop a focal therapy approach for prostate cancer have been challenged by several concepts including the multifocal nature of the disease and limited capability of prostate ultrasound and systematic biopsy to reliably localize the site(s) and aggressiveness of disease...
June 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28725586/role-of-prostate-magnetic-resonance-imaging-in-active-surveillance
#16
REVIEW
Xiaosong Meng, Andrew B Rosenkrantz, Samir S Taneja
Active surveillance (AS) has emerged as a beneficial strategy for management of low risk prostate cancer (PCa) and prevention of overtreatment of indolent disease. However, selection of patients for AS using traditional 12-core transrectal prostate biopsy is prone to sampling error and presents a challenge for accurate risk stratification. In fact, around a third of men are upgraded on repeat biopsy which disqualifies them as appropriate AS candidates. This uncertainty affects adoption of AS among patients and physicians, leading to current AS protocols involving repetitive prostate biopsies and unclear triggers for progression to definitive treatment...
June 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28725585/a-critical-comparison-of-techniques-for-mri-targeted-biopsy-of-the-prostate
#17
REVIEW
Francesco Giganti, Caroline M Moore
MRI-targeted biopsy is a promising technique that offers an improved detection of clinically significant prostate cancer over standard non-targeted biopsy. It is established that prostate MRI is of use in both the primary and repeat biopsy setting for the detection of significant prostate cancer. There are three approaches to targeting biopsies to areas of interest seen on prostate MRI. They each rely on the acquisition and reporting of a diagnostic quality multi-parametric MRI scan used to identify areas of interest, and the subsequent use of those diagnostic quality images in combination with real-time images of the prostate during the biopsy procedure...
June 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28725584/magnetic-resonance-imaging-detection-of-prostate-cancer-in-men-with-previous-negative-prostate-biopsy
#18
REVIEW
Matthew Truong, Thomas P Frye
Use of transrectal ultrasound guided systematic prostate biopsy has poor diagnostic accuracy for prostate cancer (PCa) detection. Recently multiparametric MRI (mpMRI) of the prostate and MR/US fusion biopsy has been gaining popularity for men who have previously undergone a negative biopsy. We performed PubMed(®) and Web of Science(®) searches to identify studies on this subject, particularly focusing on studies consisting of patients who have had at least one previously negative biopsy. Across the literature, when a suspicious lesion is found on mpMRI, MR/US fusion biopsy has consistently demonstrated higher detection rate for any PCa and clinically significant PCa (csPCa) compared to the traditional repeat systematic biopsy (SB) approach...
June 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28725583/positron-emission-tomography-pet-in-primary-prostate-cancer-staging-and-risk-assessment
#19
REVIEW
Sandra Bednarova, Maria L Lindenberg, Maria Vinsensia, Chiara Zuiani, Peter L Choyke, Baris Turkbey
Prostate cancer (PCa) is one of the few neoplasms that are not well served by 18F-Fluorodeoxyglucose (FDG) positron emission tomography (PET). As a result, a number of PET tracers have been developed to target particular biological features of PCa. Such agents can be used for diagnosis, staging, identification of biochemical recurrence (BCR) and evaluation of metastatic disease. Here, we focus on primary disease and local staging. To date, magnetic resonance imaging (MRI) has proven superior to PET in the imaging of primary PCa...
June 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28725582/co-registration-of-mri-and-ultrasound-accuracy-of-targeting-based-on-radiology-pathology-correlation
#20
REVIEW
Win Shun Lai, Jessica G Zarzour, Jennifer B Gordetsky, Soroush Rais-Bahrami
We reviewed the role of multiparametric magnetic resonance imaging (MP-MRI) and methods of MRI guided biopsy including in-bore, cognitive fusion, and software-based fusion. MP-MRI has been developed, optimized, and studied as a means of improving prostate cancer detection beyond the standard evaluation that utilizes digital rectal examinations and serum prostate specific antigen (PSA). MP-MRI has been proven to be an excellent diagnostic imaging modality that improves prostate cancer detection and risk stratification by guiding biopsy samples...
June 2017: Translational Andrology and Urology
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