keyword
https://read.qxmd.com/read/38499328/a-genetic-screen-to-uncover-mechanisms-underlying-lipid-transfer-protein-function-at-membrane-contact-sites
#21
JOURNAL ARTICLE
Shirish Mishra, Vaishnavi Manohar, Shabnam Chandel, Tejaswini Manoj, Subhodeep Bhattacharya, Nidhi Hegde, Vaisaly R Nath, Harini Krishnan, Corinne Wendling, Thomas Di Mattia, Arthur Martinet, Prasanth Chimata, Fabien Alpy, Padinjat Raghu
Lipid transfer proteins mediate the transfer of lipids between organelle membranes, and the loss of function of these proteins has been linked to neurodegeneration. However, the mechanism by which loss of lipid transfer activity leads to neurodegeneration is not understood. In Drosophila photoreceptors, depletion of retinal degeneration B (RDGB), a phosphatidylinositol transfer protein, leads to defective phototransduction and retinal degeneration, but the mechanism by which loss of this activity leads to retinal degeneration is not understood...
June 2024: Life Science Alliance
https://read.qxmd.com/read/38496780/editorial-on-special-collection-in-contact-vps13-and-bridge-like-lipid-transfer-proteins-a-new-mode-of-intracellular-continuity
#22
EDITORIAL
Tim P Levine, Liz Conibear
No abstract text is available yet for this article.
2024: Contact
https://read.qxmd.com/read/38490399/characterization-of-type1-lipid-transfer-protein-from-citrus-sinensis-unraveling-its-potential-as-an-antimicrobial-and-insecticidal-agent
#23
JOURNAL ARTICLE
Surabhi Rode, Harry Kaur, Monica Sharma, Vivek Shah, Shiv Shakti Singh, Mrugendra Gubyad, Dilip Kumar Ghosh, Debabrata Sircar, Pravindra Kumar, Partha Roy, Ashwani Kumar Sharma
Lipid Transfer Protein1 (LTP1) is a cationic, multifaceted protein belonging to the pathogenesis-related protein (PR14) family. Despite being involved in diverse physiological processes and defense mechanisms, the precise in-vivo role of LTP1 remains undiscovered. This work presents the characterization of recombinant Citrus sinensis LTP1 (CsLTP1) along with lipid binding studies through in-silico and in-vitro approaches. CsLTP1 demonstrated great thermal and pH stability with a huge biotechnological potential...
March 14, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38488730/vitrojet-new-features-and-case-studies
#24
JOURNAL ARTICLE
Rene J M Henderikx, Daniel Mann, Aušra Domanska, Jing Dong, Saba Shahzad, Behnam Lak, Aikaterini Filopoulou, Damian Ludig, Martin Grininger, Jeffrey Momoh, Elina Laanto, Hanna M Oksanen, Kyrylo Bisikalo, Pamela A Williams, Sarah J Butcher, Peter J Peters, Bart W A M M Beulen
Single-particle cryo-electron microscopy has become a widely adopted method in structural biology due to many recent technological advances in microscopes, detectors and image processing. Before being able to inspect a biological sample in an electron microscope, it needs to be deposited in a thin layer on a grid and rapidly frozen. The VitroJet was designed with this aim, as well as avoiding the delicate manual handling and transfer steps that occur during the conventional grid-preparation process. Since its creation, numerous technical developments have resulted in a device that is now widely utilized in multiple laboratories worldwide...
April 1, 2024: Acta Crystallographica. Section D, Structural Biology
https://read.qxmd.com/read/38486393/intermolecular-protein-water-coupling-impedes-the-coupling-between-the-amide-a-and-amide-i-mode-in-interfacial-proteins
#25
JOURNAL ARTICLE
Junjun Tan, Mengmeng Wang, Zijian Ni, Ruoqi Pei, Fangwen Shi, Shuji Ye
The coupling between different vibrational modes in proteins is essential for chemical dynamics and biological functions and is linked to the propagation of conformational changes and pathways of allosteric communication. However, little is known about the influence of intermolecular protein-H2 O coupling on the vibrational coupling between amide A (NH) and amide I (C═O) bands. Here, we investigate the NH/CO coupling strength in various peptides with different secondary structures at the lipid cell membrane/H2 O interface using femtosecond time-resolved sum frequency generation vibrational spectroscopy (SFG-VS) in which a femtosecond infrared pump is used to excite the amide A band, and SFG-VS is used to probe transient spectral evolution in the amide A and amide I bands...
March 14, 2024: Langmuir: the ACS Journal of Surfaces and Colloids
https://read.qxmd.com/read/38482694/zebrafish-apob-containing-lipoprotein-metabolism-a-closer-look
#26
REVIEW
Tabea Moll, Steven A Farber
Zebrafish have become a powerful model of mammalian lipoprotein metabolism and lipid cell biology. Most key proteins involved in lipid metabolism, including cholesteryl ester transfer protein, are conserved in zebrafish. Consequently, zebrafish exhibit a human-like lipoprotein profile. Zebrafish with mutations in genes linked to human metabolic diseases often mimic the human phenotype. Zebrafish larvae develop rapidly and externally around the maternally deposited yolk. Recent work revealed that any disturbance of lipoprotein formation leads to the accumulation of cytoplasmic lipid droplets and an opaque yolk, providing a visible phenotype to investigate disturbances of the lipoprotein pathway, already leading to discoveries in microsomal triglyceride transfer protein and ApoB (apolipoprotein B)...
March 14, 2024: Arteriosclerosis, Thrombosis, and Vascular Biology
https://read.qxmd.com/read/38479314/polystyrene-microplastics-impair-the-functions-of-cultured-mouse-leydig-tm3-and-sertoli-tm4-cells-by-inducing-mitochondrial-endoplasmic-reticulum-damage
#27
JOURNAL ARTICLE
Giulia Grillo, Sara Falvo, Debora Latino, Gabriella Chieffi Baccari, Massimo Venditti, Maria Maddalena Di Fiore, Sergio Minucci, Alessandra Santillo
Many laboratory studies demonstrated that the exposure to microplastics causes testosterone deficiency and spermatogenic impairment in mammals; however, the mechanism underlying this process remains still unclear. In this study, we investigated the effects of polystyrene microplastics (PS-MP) on the proliferation and functionality of cultured Leydig (TM3) and Sertoli (TM4) cells, focusing on the mitochondrial compartment and its association with the endoplasmic reticulum (ER). The in vitro exposure to PS-MP caused a substantial reduction in cellular viability in TM3 and TM4 cells...
March 12, 2024: Ecotoxicology and Environmental Safety
https://read.qxmd.com/read/38476233/extracellular-vesicles-and-cancer-stemness-in-hepatocellular-carcinoma-is-there-a-link
#28
REVIEW
Lu Tian, Jingyi Lu, Irene Oi-Lin Ng
Hepatocellular carcinoma (HCC) is a highly aggressive malignancy, with high recurrence rates and notorious resistance to conventional chemotherapy. Cancer stemness refers to the stem-cell-like phenotype of cancer cells and has been recognized to play important roles in different aspects of hepatocarcinogenesis. Small extracellular vesicles (sEVs) are small membranous particles secreted by cells that can transfer bioactive molecules, such as nucleic acids, proteins, lipids, and metabolites, to neighboring or distant cells...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38474328/the-long-distance-transport-of-some-plant-hormones-and-possible-involvement-of-lipid-binding-and-transfer-proteins-in-hormonal-transport
#29
REVIEW
Guzel Akhiyarova, Ekaterina I Finkina, Kewei Zhang, Dmitriy Veselov, Gulnara Vafina, Tatiana V Ovchinnikova, Guzel Kudoyarova
Adaptation to changes in the environment depends, in part, on signaling between plant organs to integrate adaptive response at the level of the whole organism. Changes in the delivery of hormones from one organ to another through the vascular system strongly suggest that hormone transport is involved in the transmission of signals over long distances. However, there is evidence that, alternatively, systemic responses may be brought about by other kinds of signals (e.g., hydraulic or electrical) capable of inducing changes in hormone metabolism in distant organs...
February 20, 2024: Cells
https://read.qxmd.com/read/38473976/cell-type-specific-extracellular-vesicles-and-their-impact-on-health-and-disease
#30
REVIEW
Sohil Amin, Hamed Massoumi, Deepshikha Tewari, Arnab Roy, Madhurima Chaudhuri, Cedra Jazayerli, Abhi Krishan, Mannat Singh, Mohammad Soleimani, Emine E Karaca, Arash Mirzaei, Victor H Guaiquil, Mark I Rosenblatt, Ali R Djalilian, Elmira Jalilian
Extracellular vesicles (EVs), a diverse group of cell-derived exocytosed particles, are pivotal in mediating intercellular communication due to their ability to selectively transfer biomolecules to specific cell types. EVs, composed of proteins, nucleic acids, and lipids, are taken up by cells to affect a variety of signaling cascades. Research in the field has primarily focused on stem cell-derived EVs, with a particular focus on mesenchymal stem cells, for their potential therapeutic benefits. Recently, tissue-specific EVs or cell type-specific extracellular vesicles (CTS-EVs), have garnered attention for their unique biogenesis and molecular composition because they enable highly targeted cell-specific communication...
February 27, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38473850/antioxidant-metabolism-pathways-in-vitamins-polyphenols-and-selenium-parallels-and-divergences
#31
REVIEW
Celia María Curieses Andrés, José Manuel Pérez de la Lastra, Celia Andrés Juan, Francisco J Plou, Eduardo Pérez-Lebeña
Free radicals (FRs) are unstable molecules that cause reactive stress (RS), an imbalance between reactive oxygen and nitrogen species in the body and its ability to neutralize them. These species are generated by both internal and external factors and can damage cellular lipids, proteins, and DNA. Antioxidants prevent or slow down the oxidation process by interrupting the transfer of electrons between substances and reactive agents. This is particularly important at the cellular level because oxidation reactions lead to the formation of FR and contribute to various diseases...
February 23, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38468535/the-role-of-sars-cov-2-spike-protein-in-long-term-damage-of-tissues-and-organs-the-underestimated-role-of-retrotransposons-and-stem-cells-a-working-hypothesis
#32
JOURNAL ARTICLE
Mario G Balzanelli, Reza Rastanesh, Pietro Distratis, Rita Lazzaro, Francesco Inchingolo, Raffaele Del Prete, Van H Pham, Sergey K Aityan, Toai Tran Cong, Kieu C D Nguyen, Ciro Gargiulo Isacco
Coronavirus disease-2019 (COVID-19) is a respiratory disease in which Spike protein from SARS-CoV-2 plays a key role in transferring virus genomic code into target cells. Spike protein, which is found on the surface of the SARS-CoV-2 virus, latches onto angiotensin-converting enzyme 2 receptors (ACE2r) on target cells. The RNA genome of coronaviruses, with an average length of 29 kb, is the longest among all RNA viruses and comprises six to ten open reading frames (ORFs) responsible for encoding replicase and structural proteins for the virus...
March 11, 2024: Endocrine, Metabolic & Immune Disorders Drug Targets
https://read.qxmd.com/read/38467907/the-tam-a-translocation-and-assembly-module-for-protein-assembly-and-potential-conduit-for-phospholipid-transfer
#33
REVIEW
Kwok Jian Goh, Christopher J Stubenrauch, Trevor Lithgow
The assembly of β-barrel proteins into the bacterial outer membrane is an essential process enabling the colonization of new environmental niches. The TAM was discovered as a module of the β-barrel protein assembly machinery; it is a heterodimeric complex composed of an outer membrane protein (TamA) bound to an inner membrane protein (TamB). The TAM spans the periplasm, providing a scaffold through the peptidoglycan layer and catalyzing the translocation and assembly of β-barrel proteins into the outer membrane...
March 11, 2024: EMBO Reports
https://read.qxmd.com/read/38464273/nir1-lns2-is-a-novel-phosphatidic-acid-biosensor-that-reveals-mechanisms-of-lipid-production
#34
Claire C Weckerly, Taylor A Rahn, Max Ehrlich, Rachel C Wills, Joshua G Pemberton, Michael V Airola, Gerald R V Hammond
Despite various roles of phosphatidic acid (PA) in cellular functions such as lipid homeostasis and vesicular trafficking, there is a lack of high-affinity tools to study PA in live cells. After analysis of the predicted structure of the LNS2 domain in the lipid transfer protein Nir1, we suspected that this domain could serve as a novel PA biosensor. We created a fluorescently tagged Nir1-LNS2 construct and then performed liposome binding assays as well as pharmacological and genetic manipulations of HEK293A cells to determine how specific lipids affect the interaction of Nir1-LNS2 with membranes...
February 28, 2024: bioRxiv
https://read.qxmd.com/read/38462608/angptl3-is-a-novel-hdl-component-that-regulates-hdl-function
#35
JOURNAL ARTICLE
Longyan Yang, Yan Wang, Yongsong Xu, Kun Li, Ruili Yin, Lijie Zhang, Di Wang, Lingling Wei, Jianan Lang, Yanan Cheng, Lu Wang, Jing Ke, Dong Zhao
BACKGROUND: Angiopoietin-like protein 3 (ANGPTL3) is secreted by hepatocytes and inhibits lipoprotein lipase and endothelial lipase activity. Previous studies reported the correlation between plasma ANGPTL3 levels and high-density lipoprotein (HDL). Recently ANGPTL3 was found to preferentially bind to HDL in healthy human circulation. Here, we examined whether ANGPTL3, as a component of HDL, modulates HDL function and affects HDL other components in human and mice with non-diabetes or type 2 diabetes mellitus...
March 10, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38449011/understanding-of-lipid-transfer-protein-sensitization-patterns-and-its-clinical-significance-in-children
#36
JOURNAL ARTICLE
Alp Kazancioglu, Ilteber Konuralp, Umit Murat Sahiner, Ozge Soyer, Bulent Enis Sekerel
Background: Lipid transfer proteins (LTP) are the most common food allergens in the Mediterranean region. Objective: The study aimed to investigate co-sensitization patterns and cluster relationships between LTP allergen molecules across a broad range of allergen-specific sensitization patterns, and clinical outcomes in eastern Mediterranean children. Methods: Among 496 children evaluated for multiple sensitizations with multiplex testing, 105 children (21%) with 16 different LTP sensitizations were analyzed...
March 1, 2024: Allergy and Asthma Proceedings:
https://read.qxmd.com/read/38447014/intracellular-lipase-and-regulation-of-the-lipid-droplet
#37
JOURNAL ARTICLE
Ainara G Cabodevilla, Ni Son, Ira J Goldberg
PURPOSE OF REVIEW: Lipid droplets are increasingly recognized as distinct intracellular organelles that have functions exclusive to the storage of energetic lipids. Lipid droplets modulate macrophage inflammatory phenotype, control the availability of energy for muscle function, store excess lipid, sequester toxic lipids, modulate mitochondrial activity, and allow transfer of fatty acids between tissues. RECENT FINDINGS: There have been several major advances in our understanding of the formation, dissolution, and function of this organelle during the past two years...
April 1, 2024: Current Opinion in Lipidology
https://read.qxmd.com/read/38446078/food-dependent-exercise-induced-allergic-reactions-in-lipid-transfer-protein-ltp-hypersensitive-subjects-new-data-and-a-critical-reappraisal
#38
JOURNAL ARTICLE
E Scala, V Villella, R Asero
Background. Lipid transfer protein is the main cause of both primary food allergy and food-dependent exercise-induced allergic reactions (FDEIAR) in Italy. What characterizes LTP-hypersensitive patients with FDEIAR is still unclear. We investigated the key characteristics of LTP-hypersensitive patients with or without FDEIAR in a large cohort of individuals sensitized to this allergen. Methods. 1,203 food-allergic patients, diagnosed on the basis of unequivocal clinical history and presence of circulating food allergen-specific IgE were studied...
March 6, 2024: European Annals of Allergy and Clinical Immunology
https://read.qxmd.com/read/38445789/microsomal-triglyceride-transfer-protein-is-necessary-to-maintain-lipid-homeostasis-and-retinal-function
#39
JOURNAL ARTICLE
Catharina R Grubaugh, Anuradha Dhingra, Binu Prakash, Diego Montenegro, Janet R Sparrow, Lauren L Daniele, Christine A Curcio, Brent A Bell, M Mahmood Hussain, Kathleen Boesze-Battaglia
Lipid processing by the retinal pigment epithelium (RPE) is necessary to maintain retinal health and function. Dysregulation of retinal lipid homeostasis due to normal aging or age-related disease triggers lipid accumulation within the RPE, on Bruch's membrane (BrM), and in the subretinal space. In its role as a hub for lipid trafficking into and out of the neural retina, the RPE packages a significant amount of lipid into lipid droplets for storage and into apolipoprotein B (APOB)-containing lipoproteins (Blps) for export...
March 15, 2024: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/38438780/strain-promoted-cycloadditions-in-lipid-bilayers-triggered-by-liposome-fusion
#40
JOURNAL ARTICLE
Coline Jumeaux, Christopher D Spicer, Patrick Charchar, Philip D Howes, Margaret N Holme, Li Ma, Nicholas C Rose, Joe Nabarro, Martin A Fascione, M Harunur Rashid, Irene Yarovsky, Molly M Stevens
Due to the variety of roles served by the cell membrane, its composition and structure are complex, making it difficult to study. Bioorthogonal reactions, such as the strain promoted azide-alkyne cycloaddition (SPAAC), are powerful tools for exploring the function of biomolecules in their native environment but have been largely unexplored within the context of lipid bilayers. Here, we developed a new approach to study the SPAAC reaction in liposomal membranes using azide- and strained alkyne-functionalized Förster resonance energy transfer (FRET) dye pairs...
March 4, 2024: Angewandte Chemie
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