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Prostate biopsy

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https://www.readbyqxmd.com/read/28325017/diffuse-reflectance-spectroscopy-can-differentiate-high-grade-and-low-grade-prostatic-carcinoma
#1
Priya N Werahera, Edward A Jasion, E David Crawford, M Scott Lucia, Adrie van Bokhoven, Holly T Sullivan, Fernando J Kim, Paul D Maroni, J David Port, John W Daily, Francisco G La Rosa
Prostate tumors are graded by the revised Gleason Score (GS) which is the sum of the two predominant Gleason grades present ranging from 6-10. GS 6 cancer exclusively with Gleason grade 3 is designated as low grade (LG) and correlates with better clinical prognosis for patients. GS >7 cancer with at least one of the Gleason grades 4 and 5 is designated as HG indicate worse prognosis for patients. Current transrectal ultrasound guided prostate biopsies often fail to correctly diagnose HG prostate cancer due to sampling errors...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28324340/quantitative-18-f-fluorocholine-positron-emission-tomography-for-prostate-cancer-correlation-between-kinetic-parameters-and-gleason-scoring
#2
Joshua J D Schaefferkoetter, Ziting Wang, Mary C Stephenson, Sharmili Roy, Maurizio Conti, Lars Eriksson, David W Townsend, Thomas Thamboo, Edmund Chiong
BACKGROUND: The use of radiolabeled choline as a positron emission tomography (PET) agent for imaging primary tumors in the prostate has been evaluated extensively over the past two decades. There are, however, conflicting reports of its sensitivity and the relationship between choline PET imaging and disease staging is not fully understood. Moreover, relatively few studies have investigated the correlation between tracer uptake and histological tumor grade. This work quantified (18)F-fluorocholine in tumor and healthy prostate tissue using pharmacokinetic modeling and stratified uptake parameters by histology grade...
December 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28319496/the-utility-of-68ga-psma-pet-ct-in-poorly-differentiated-metastatic-prostate-cancer
#3
Mehmet Onur Demirkol, Murat Can Kiremit, Omer Acar, Burcu Ucar, Yesim Saglican
We aimed to emphasize how useful PSMA PET/CT findings can be while trying to restage prostate cancer after radical prostatectomy in the presence of low prostate-specific antigen values. A 64-year-old man with pT3b N1 M0 Gleason 7 adenocarcinoma of the prostate presented 5 years postoperatively with a palpable axillary mass, whereas his prostate-specific antigen was 0.08 ng/mL. Conventional imaging studies and histopathologic findings of the axillary mass biopsy revealed inconclusive results. Ga-PSMA PET/CT demonstrated PSMA-positive metastatic lesions, the largest one being located in the right axilla...
March 17, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28317149/association-between-variants-in-genes-involved-in-the-immune-response-and-prostate-cancer-risk-in-men-randomized-to-the-finasteride-arm-in-the-prostate-cancer-prevention-trial
#4
Danyelle A Winchester, Cathee Till, Phyllis J Goodman, Catherine M Tangen, Regina M Santella, Teresa L Johnson-Pais, Robin J Leach, Jianfeng Xu, S Lilly Zheng, Ian M Thompson, M Scott Lucia, Scott M Lippman, Howard L Parnes, William B Isaacs, Angelo M De Marzo, Charles G Drake, Elizabeth A Platz
BACKGROUND: We reported that some, but not all single nucleotide polymorphisms (SNPs) in select immune response genes are associated with prostate cancer, but not individually with the prevalence of intraprostatic inflammation in the Prostate Cancer Prevention Trial (PCPT) placebo arm. Here, we investigated whether these same SNPs are associated with risk of lower- and higher-grade prostate cancer in men randomized to finasteride, and with prevalence of intraprostatic inflammation among controls...
March 20, 2017: Prostate
https://www.readbyqxmd.com/read/28315427/histologic-features-of-stromogenic-carcinoma-of-the-prostate-carcinomas-with-reactive-stroma-grade-3
#5
Andrea Diaz De Vivar, Mohammad Sayeeduddin, David Rowley, Antonio Cubilla, Brian Miles, Dov Kadmon, Gustavo Ayala
Prostatic carcinoma, like many other carcinomas, generates a stromal reaction. This phenomenon is well established in the scientific literature. The normal parenchymal smooth muscle phenotype switches to a myofibroblastic phenotype in response to the presence of cancer cells, with an expansion of the extracellular matrix compartment. The amount of reactive stroma is a predictor of biochemical recurrence in both radical prostatectomies and biopsies. It is a predictor of prostate cancer specific death in prostatectomies...
March 14, 2017: Human Pathology
https://www.readbyqxmd.com/read/28306604/role-of-mri-in-low-risk-prostate-cancer-finding-the-wolf-in-sheep-s-clothing-or-the-sheep-in-wolf-s-clothing
#6
Ivo G Schoots, Caroline M Moore, Olivier Rouvière
PURPOSE OF REVIEW: In men on active surveillance for localized prostate cancer, MRI and MRI-targeted biopsies can be used prior to confirmatory or surveillance biopsy, to detect individuals with high-grade cancer (the wolf in sheep's clothing). However, some men will have low-risk disease despite adverse MRI findings (the sheep in wolf's clothing). We review the value addition of MRI-targeted biopsies in comparison to systematic transrectal ultrasound-guided biopsies, using pathological reclassification as an end-point...
March 16, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/28300861/primary-cribriform-carcinoma-of-the-eyelid-with-neuroendocrine-features-a-case-report
#7
Joshua D Fox, Sander R Dubovy, Sara T Wester, Keyvan Nouri
A variety of tumors may involve the eyelid, most of which are primary, but rarely can be metastatic. Previously reported eyelid primary carcinomas with neuroendocrine features include Merkel cell carcinoma, apocrine and eccrine gland carcinoma, sebaceous gland carcinoma, and one report of primary "well-differentiated neuroendocrine tumor." Herein we report the first case of primary cribriform carcinoma of the eyelid with neuroendocrine features. The patient is a 75-year-old black man who presented to the clinic with a 5-year history of a slowly growing, non-painful, non-exudative lesion of his left lower eyelid...
February 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28299763/the-efficacy-of-transrectal-ultrasound-guided-biopsy-versus-transperineal-template-biopsy-of-the-prostate-in-diagnosing-prostate-cancer-in-men-with-previous-negative-transrectal-ultrasound-guided-biopsy
#8
Shady Nafie, Michael Wanis, Masood Khan
PURPOSE: We have previously demonstrated that transperineal template prostate biopsy (TPTPB) has a significantly higher cancer detection rate compared to transrectal ultrasound guided (TRUS) biopsy in biopsy naive men with a PSA < 20 ng/mL. We, therefore, performed a prospective study to determine whether TPTPB is still superior to TRUS biopsy in the detection of prostate cancer in men with persistently elevated PSA after one previous negative set of TRUS biopsies. MATERIALS AND METHODS: 42 patients with a background of one previous negative set of TRUS biopsy, persistently elevated PSA (but < 20 ng/mL) and benign feeling digital rectal examination (DRE) underwent simultaneous standard 12-core TRUS biopsy and 36-core TPTPB under general anaesthesia...
March 16, 2017: Urology Journal
https://www.readbyqxmd.com/read/28295933/high-concordance-of-findings-obtained-from-in-gantry-transgluteal-mri-and-trus-guided-biopsy-as-compared-to-prostatectomy-specimens
#9
Stefan Steurer, Sebastian Dwertmann Rico, Ronald Simon, Sarah Minner, Maria Christina Tsourlakis, Till Krech, Christina Koop, Markus Graefen, Hans Heinzer, Meike Adam, Hartwig Huland, Thorsten Schlomm, Guido Sauter, Agron Lumiani
OBJECTIVES: To determine the utility of our transgluteal MRI-guided prostate biopsy approach. PATIENTS AND METHODS: 960 biopsy series taken within the period of one year were evaluated including 301 MRI-guided and 659 TRUS-guided biopsies. RESULTS: The positivity rate and the fraction of high-grade cancers were significantly higher in MRI-guided than in TRUS biopsies. 65.4% of 301 MRI-guided and 57.2% of 659 TRUS biopsies contained cancer (p=0...
March 13, 2017: BJU International
https://www.readbyqxmd.com/read/28295573/therapeutic-plasma-exchange-for-perioperative-management-of-patients-with-congenital-factor-xi-deficiency
#10
Mohamed S Alsammak, Aneel A Ashrani, Jeffrey L Winters, Rajiv K Pruthi
BACKGROUND: Factor XI (FXI) deficiency (hemophilia C [HEM-C]) is a bleeding disorder with unpredictable severity that correlates poorly with FXI coagulation activity (FXI:C). It poses a perioperative hemostatic management challenge. For US patients with severe disease, fresh frozen plasma (FFP) or, in current use, thawed plasma is the most readily available option but comes with risk of volume overload. We report our experience of using therapeutic plasma exchange (TPE) as an alternative perioperative management strategy...
March 15, 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/28295504/testosterone-therapy-has-positive-effects-on-anthropometric-measures-metabolic-syndrome-components-obesity-lipid-profile-diabetes-mellitus-control-blood-indices-liver-enzymes-and-prostate-health-indicators-in-elderly-hypogonadal-men
#11
O Canguven, R A Talib, W El Ansari, D-J Yassin, M Salman, A Al-Ansari
To alleviate late-onset hypogonadism, testosterone treatment is offered to suitable patients. Although testosterone treatment is commonly given to late-onset hypogonadism patients, there remains uncertainty about the metabolic effects during follow-ups. We assessed the associations between testosterone treatment and wide range of characteristics that included hormonal, anthropometric, biochemical features. Patients received intramuscular 1,000 mg testosterone undecanoate for 1 year. Patient anthropometric measurements were undertaken at baseline and at each visit, and blood samples were drawn at each visit, prior to the next testosterone undecanoate...
March 10, 2017: Andrologia
https://www.readbyqxmd.com/read/28293720/pathologic-correlation-of-transperineal-in-bore-3-tesla-magnetic-resonance-imaging-guided-prostate-biopsy-samples-with-radical-prostatectomy-specimen
#12
Erik Velez, Andriy Fedorov, Kemal Tuncali, Olutayo Olubiyi, Christopher B Allard, Adam S Kibel, Clare M Tempany
PURPOSE: To determine the accuracy of in-bore transperineal 3-Tesla (T) magnetic resonance (MR) imaging-guided prostate biopsies for predicting final Gleason grades in patients who subsequently underwent radical prostatectomy (RP). METHODS: A retrospective review of men who underwent transperineal MR imaging-guided prostate biopsy (tpMRGB) with subsequent radical prostatectomy within 1 year was conducted from 2010 to 2015. All patients underwent a baseline 3-T multiparametric MRI (mpMRI) with endorectal coil and were selected for biopsy based on MR findings of a suspicious prostate lesion and high degree of clinical suspicion for cancer...
March 14, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28293631/urinary-biomarker-panel-to-improve-accuracy-in-predicting-prostate-biopsy-result-in-chinese-men-with-psa-4-10%C3%A2-ng-ml
#13
Yongqiang Zhou, Yun Li, Xiangnan Li, Minjun Jiang
This study aims to evaluate the effectiveness and clinical performance of a panel of urinary biomarkers to diagnose prostate cancer (PCa) in Chinese men with PSA levels between 4 and 10 ng/mL. A total of 122 patients with PSA levels between 4 and 10 ng/mL who underwent consecutive prostate biopsy at three hospitals in China were recruited. First-catch urine samples were collected after an attentive prostate massage. Urinary mRNA levels were measured by quantitative real-time polymerase chain reaction (qRT-PCR)...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28292387/does-small-prostate-predict-high-grade-prostate-cancer
#14
(no author information available yet)
OBJECTIVE: The current is study aimed to assess the patients who underwent radical prostatectomy for prostate cancer and investigate the association between prostate size and adverse outcomes at final pathology. STUDY DESIGN: Comparative, descriptive study. PLACE AND DURATION OF STUDY: Haydarpasa Numune Training and Research Hospital, Turkey, from January 2008 to January 2016. METHODOLOGY: The patients treated with open radical prostatectomy for prostate cancer were reviewed...
February 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28291903/prostate-volume-index-stratified-prostate-cancer-risk-in-patients-elected-to-a-first-random-biopsy-set
#15
Antonio B Porcaro, Paolo Corsi, Nicolò de Luyk, Marco Sebben, Alessandro Tafuri, Leonardo Bizzotto, Giovanni Cacciamani, Davide De Marchi, Tania Processali, Daniele Mattevi, Giovanni Novella, Maria A Cerruto, Matteo Brunelli, Salvatore Siracusano, Walter Artibani
OBJECTIVE: To investigate prostate volume index (PVI), defined as the ratio of volume of the transitional zone on that of the peripheral zone, as a factor stratifying prostate cancer (PCA) risk in patients elected to a first random biopsy set. METHODS: The study evaluated 596 patients who were elected to a first random biopsy set because of suspected PCA in a period between September 2010 and September 2015. Prostate volume index was dichotomized to PVI ≤1 vs PVI >1...
February 28, 2017: Tumori
https://www.readbyqxmd.com/read/28289065/gleason-grade-grouping-of-prostate-cancer-is-of-prognostic-value-in-asian-men
#16
Joe Yeong, Rehena Sultana, Jonathan Teo, Hong Hong Huang, John Yuen, Puay Hoon Tan, Li Yan Khor
AIM: The International Society of Urological Pathology made recommendations for the use of Grade Groups (GG) originally described by Epstein and colleagues over Gleason score (GS) alone in 2014, which was subsequently adopted by the WHO classification in 2016. The majority of studies validating this revision have been in Caucasian populations. We therefore asked whether the new GG system was retrospectively associated with biochemical disease-free survival in a mixed-ethnicity cohort of Asian men...
March 13, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28288838/routine-ertapenem-prophylaxis-for-transrectal-ultrasound-guided-prostate-biopsy-does-not-select-for-carbapenem-resistant-organisms-a-prospective-cohort-study
#17
Maxim G Bloomfield, Matthew J Page, Alice G McLachlan, Rodney C Studd, Timothy K Blackmore
PURPOSE: Post-transrectal ultrasound-guided prostate biopsy sepsis is an increasing problem in this era of rising antibiotic resistance. Ertapenem prophylaxis has proven very effective at our institution for reducing this, however has raised local and regional antimicrobial stewardship concerns. This study investigated the possible selective effect of single dose ertapenem prophylaxis on fecal colonization with carbapenem-resistant Enterobacteriaceae. MATERIALS AND METHODS: Patients had a rectal swab taken prior to receiving pre-biopsy ertapenem prophylaxis...
March 10, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28285790/diagnosis-and-treatment-for-clinically-localized-prostate-cancer-adherence-to-the-european-association-of-urology-clinical-guidelines-in-a-nationwide-population-based-study-gescap-group
#18
F Gómez-Veiga, A Rodríguez-Antolín, B Miñana, C Hernández, J F Suárez, J M Fernández-Gómez, M Unda, J Burgos, A Alcaraz, P Rodríguez, R Medina, J Castiñeiras, C Moreno, E Pedrosa, J M Cózar
OBJECTIVE: To assess the adherence to European Association of Urology (EAU) guidelines in the management of prostate cancer (PCa) in Spain. PATIENTS AND METHODS: Epidemiological, population-based, study including a national representative sample of 3,918 incident patients with histopathological confirmation during 2010; 95% of the patient's sample was followed up for at least one year. Diagnosis along with treatment related variables (for localized PCa -low, intermediate, high and locally-advanced by D'Amico risk stratification) was recorded...
March 9, 2017: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/28283782/prostate-transitional-zone-volume-based-nomogram-for-predicting-prostate-cancer-and-high-progression-prostate-cancer-in-a-real-world-population
#19
Yanqing Wang, Shaowei Xie, Xun Shangguan, Jiahua Pan, Yinjie Zhu, Zhixiang Xin, Fan Xu, Xiaoguang Shao, Liancheng Fan, Jianjun Sha, Qiang Liu, Baijun Dong, Wei Xue
PURPOSE: To evaluate and compare the efficacy of prostate volume (PV), transitional zone volume (TZV), and prostate volume index (PVI, the ratio of TZV to peripheral zone volume) in the identification of men at risk of prostate cancer (PCa) and high-progression PCa (HPPCa) at the initial biopsy (IBX) in a real-world population. METHODS: From Jul 2014 to Aug 2016, data on 1144 patients who had undergone the initial prostate biopsies were prospectively collected and analyzed...
March 10, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28282997/is-there-a-protective-role-of-testosterone-against-high-grade-prostate-cancer-incidence-and-severity-of-prostate-cancer-in-553-patients-who-underwent-prostate-biopsy-a-prospective-data-register
#20
Aksam Yassin, Mahmoud Salman, Riadh A Talib, Dany-Jan Yassin
This study investigated the role of testosterone replacement therapy (TRT) in prostate safety and cancer progression. A cohort of 553 patients, 42 treated and 162 untreated hypogonadal men, and 349 eugonadal men were included. Pathological analysis of prostate biopsies examining the incidence and severity of PCa revealed that: 16.7% of treated hypogonadal men had a positive biopsy, a Gleason score of ≤6 in 71.4% and >6 in 28.6% of men, a predominant score of 3 and tumour staging of II in 85.7% men; 51...
March 10, 2017: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
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