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https://www.readbyqxmd.com/read/27922627/blood-based-and-urinary-prostate-cancer-biomarkers-a-review-and-comparison-of-novel-biomarkers-for-detection-and-treatment-decisions
#1
REVIEW
R J Hendriks, I M van Oort, J A Schalken
BACKGROUND: The diagnosis of prostate cancer (PCa) is currently based on serum PSA testing and/or abnormal digital rectal examination and histopathologic evaluation of prostate biopsies. The main drawback of PSA testing is the lack of specificity for PCa. To improve early detection of PCa more specific biomarkers are needed. In the past few years, many new promising biomarkers have been identified; however, to date, only a few have reached clinical practice. METHODS: In this review, we discuss new blood-based and urinary biomarker models that are promising for usage in PCa detection, follow-up and treatment decision-making...
December 6, 2016: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/27921275/preoperative-characteristics-of-the-p-r-o-s-t-a-t-e-scores-a-novel-predictive-tool-for-the-risk-of-positive-surgical-margin-after-radical-prostatectomy
#2
Ben Xu, Cheng Luo, Qian Zhang, Jie Jin
OBJECTIVES: To propose a novel scoring system to predict the risk of positive surgical margin (PSM) after radical prostatectomy (RP) in prostate cancer (PCa) patients. MATERIALS AND METHODS: Eight reproducible variables available from preoperative characteristics of PCa patients were measured: PSA level (P), ratio of positive biopsy needles (R), obesity (O), scores of Gleason (S), T stage by preoperative MRI scan (T), age (A), tumor volume (T) and experience of the surgeon (E)...
December 5, 2016: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/27919668/magnetic-resonance-imaging-provides-added-value-to-the-prostate-cancer-prevention-trial-risk-calculator-for-patients-with-estimated-risk-of-high-grade-prostate-cancer-less-than-or-equal-to-10
#3
Eric H Kim, John K Weaver, Anup S Shetty, Joel M Vetter, Gerald L Andriole, Seth A Strope
OBJECTIVES: To determine the added value of prostate MRI to the Prostate Cancer Prevention Trial risk calculator. METHODS: Between January 2012 and December 2015, 339 patients underwent prostate MRI prior to biopsy at our institution. MRI was considered positive if there was at least one Prostate Imaging Reporting and Data System 4 or 5 MRI suspicious region. Logistic regression was used to develop two models: biopsy outcome as a function of the 1) Prostate Cancer Prevention Trial risk calculator alone, and 2) combined with MRI findings...
December 2, 2016: Urology
https://www.readbyqxmd.com/read/27919653/transperineal-biopsies-of-mri-detected-aggressive-index-lesions-in-low-%C3%A2-and-intermediate-risk-prostate-cancer-patients-implications-for-treatment-decision
#4
A Gomez-Iturriaga, F Casquero, J I Lopez, A Urresola, A Ezquerro, D Buscher, P Bilbao, J Crook
PURPOSE: Multiparametric MRI (mpMRI) has a potential role for the identification of aggressive cancer that can be targeted for biopsy. We report the incidence and severity of discordant information between the pathology found on the transrectal ultrasound (TRUS)-guided biopsy and the mpMRI findings in patients with favorable or intermediate-risk prostate cancer referred for brachytherapy. METHODS AND MATERIALS: From March 2014 to September 2015, 10/44 consecutive patients with low- or intermediate-risk prostate cancer referred for brachytherapy presented an aggressive lesion on mpMRI and underwent an MRI-TRUS fusion-guided transperineal biopsy of the index lesion...
December 2, 2016: Brachytherapy
https://www.readbyqxmd.com/read/27919140/-undifferentiated-prostate-cancer-treated-with-radiation-therapy
#5
Hiroto Osakabe, Kenji Tamura, Ichiro Yamasaki, Satoshi Fukata, Shingo Ashida, Makoto Hiroi, Masanobu Tanimura, Keiji Inoue, Taro Shuin
We describe a 75-year-old man with undifferentiated prostate cancer that was treated with radiation therapy. He presented at a nearby general hospital with dysuria and pain upon micturition. He was diagnosed with undifferentiated prostate cancer by a needle biopsy and referred to our hospital for further examination and treatment. Enhanced computed tomography and magnetic resonance images showed prostate cancer and right obturator lymph node metastasis measuring 2.5 cm. Cystoscopy and colonoscopy revealed direct invasion of the urinary bladder and rectum...
November 2016: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/27915475/how-precisely-can-prostate-cancer-be-managed
#6
REVIEW
Liyan Zhuang, Matthew T Johnson
Progress has been made in applying genetic information to disease management in the postgenomic era, and precision medicine is emerging in prostate cancer management. The prostate health index, the 4-kallikrein (4K) score, and the PCA3, TMPRSS2- ERG, and Prostarix tests have potential for refining prostate cancer screening in conjunction with traditional prostate-specific antigen testing. The Confirm MDx and PCA3 tests have shown promise in identifying men who need be rebiopsied after a primary negative biopsy...
November 2016: International Neurourology Journal
https://www.readbyqxmd.com/read/27913051/erg-expression-in-multiple-myeloma-a-potential-diagnostic-pitfall
#7
Juliana Knief, Katharina Reddemann, Jan Gliemroth, Swantje Brede, Tobias Bartscht, Christoph Thorns
INTRODUCTION: ERG expression has been described as a frequent event in prostate cancer indicating poor prognosis and promoting oncogenesis. It has also been demonstrated in Ewing's sarcoma, acute myeloid leukemia and acute T-lymphoblastic leukemia but could not be found in other epithelial tumors, Hodgkin's or Non-Hodgkin's lymphoma. We aimed to analyze ERG expression in multiple myeloma, following an index case of a patient with metastases of unknown origin in the spine strongly expressing ERG, which were thought to be of prostatic origin but turned out to be plasmacytic lesions...
November 3, 2016: Pathology, Research and Practice
https://www.readbyqxmd.com/read/27910903/prostate-cancer-patients-negative-biopsy-controls-discrimination-by-untargeted-metabolomics-analysis-of-urine-by-lc-qtof-upstream-information-on-other-omics
#8
M A Fernández-Peralbo, E Gómez-Gómez, M Calderón-Santiago, J Carrasco-Valiente, J Ruiz-García, M J Requena-Tapia, M D Luque de Castro, F Priego-Capote
The existing clinical biomarkers for prostate cancer (PCa) diagnosis are far from ideal (e.g., the prostate specific antigen (PSA) serum level suffers from lack of specificity, providing frequent false positives leading to over-diagnosis). A key step in the search for minimum invasive tests to complement or replace PSA should be supported on the changes experienced by the biochemical pathways in PCa patients as compared to negative biopsy control individuals. In this research a comprehensive global analysis by LC-QTOF was applied to urine from 62 patients with a clinically significant PCa and 42 healthy individuals, both groups confirmed by biopsy...
December 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27910803/the-prognostic-and-predictive-value-of-tmprss2-erg-gene-fusion-and-erg-protein-expression-in-prostate-cancer-biopsies
#9
Kasper Drimer Berg
BACKGROUND: The clinical course of prostate carcinoma (PCa) is very heterogeneous. Consequently, a personalised approach for risk stratification and treatment planning is important. Recently, it has become evident that PCa, also at the genomic level, is heterogeneous. An early and common alteration is the gene fusion between the transmembrane protease serine 2 (TMPRSS2) gene and the v-ets avian erythroblastosis virus E26 oncogene homolog (ERG) gene resulting in expression of the oncoprotein ERG...
December 2016: Danish Medical Journal
https://www.readbyqxmd.com/read/27906722/location-and-grade-of-prostate-cancer-diagnosed-by-transperineal-template-guided-mapping-biopsy-after-negative-transrectal-ultrasound-guided-biopsy
#10
Nathan Bittner, Gregory Merrick, Al Taira, Abbey Bennett, Amy Schattel, Wayne Butler, Robert Galbreath, Edward Adamovich
OBJECTIVES: To determine the location and grade of prostate cancer diagnosed by transperineal template-guided mapping (TTMB) after negative transrectal ultrasound-guided (TRUS) biopsy. MATERIALS AND METHODS: This analysis consisted of 1118 consecutive patients who underwent TTMB from January 2005 to August 2015. Eight hundred thirty-five underwent TTMB after at least 1 negative TRUS biopsy and 283 underwent TTMB as the first biopsy procedure. The study population was divided into cohorts based on the number of prior TRUS biopsy sessions (0, 1, 2, and ≥3)...
November 30, 2016: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27905327/potential-therapeutic-effect-of-epigenetic-therapy-on-treatment-induced-neuroendocrine-prostate-cancer
#11
Xiang Xu, Yu-Hua Huang, Yan-Jing Li, Alexa Cohen, Zhen Li, Jill Squires, Wei Zhang, Xu-Feng Chen, Min Zhang, Jiao-Ti Huang
Although adenocarcinomas of the prostate are relatively indolent, some patients with advanced adenocarcinomas show recurrence of treatment-induced neuroendocrine prostate cancer, which is highly aggressive and lethal. Detailed biological features of treatment-induced neuroendocrine prostate cancer have not been characterized owing to limited biopsies/resections and the lack of a cellular model. In this study, we used a unique cellular model (LNCaP/NE1.8) to investigate the potential role of cancer stem cells in treatment-induced neuroendocrine prostate cancer with acquired resistance to hormonal therapy and chemotherapy...
November 29, 2016: Asian Journal of Andrology
https://www.readbyqxmd.com/read/27904624/application-of-transrectal-ultrasound-guided-repeat-needle-biopsy-in-the-diagnosis-of-prostate-cancer-in-chinese-population-a-retrospective-study
#12
Yi Wang, Xizhi Wang, Jiang Yu, Jun Ouyang, Weidong Shen, Yibin Zhou, Jianquan Hou, Duangai Wen, Jinxian Pu, Yuxi Shan, Boxin Xue
BACKGROUND: Transrectal ultrasound-guided repeat needle biopsy (TUGRNB) is widely used for diagnosis of prostate cancer (PCa). However, significance of TUGRNB in Chinese population was rarely reported. A retrospective study was conducted to evaluate the significance of TUGRNB applied in prediction of PCa in Chinese population. MATERIALS AND METHODS: A total of 960 from January 2009 to December 2012 were included. Repeat needle biopsy rate and PCa positive detection rate were evaluated...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/27903962/targeted-proteomics-in-urinary-extracellular-vesicles-identifies-biomarkers-for-diagnosis-and-prognosis-of-prostate-cancer
#13
Tamara Sequeiros, Marina Rigau, Cristina Chiva, Melania Montes, Iolanda Garcia-Grau, Marta Garcia, Sherley Diaz, Ana Celma, Irene Bijnsdorp, Alex Campos, Primiano Di Mauro, Salvador Borrós, Jaume Reventós, Andreas Doll, Rosanna Paciucci, Michiel Pegtel, Inés de Torres, Eduard Sabidó, Juan Morote, Mireia Olivan
Rapid and reliable diagnosis of prostate cancer (PCa) is highly desirable as current used methods lack specificity. In addition, identification of PCa biomarkers that can classify patients into high- and low-risk groups for disease progression at early stage will improve treatment decision-making. Here, we describe a set of protein-combination panels in urinary extracellular vesicles (EVs), defined by targeted proteomics and immunoblotting techniques that improve early non-invasive detection and stratification of PCa patients...
November 26, 2016: Oncotarget
https://www.readbyqxmd.com/read/27900453/incidence-grade-and-distribution-of-prostate-cancer-following-transperineal-template-guided-mapping-biopsy-in-patients-with-atypical-small-acinar-proliferation
#14
Gregory S Merrick, Robert W Galbreath, Abbey Bennett, Wayne M Butler, Edward Amamovich
PURPOSE: To evaluate the role of transperineal template-guided mapping biopsy (TTMB) in patients with atypical small acinar proliferation (ASAP) diagnosed via transrectal ultrasound-guided needle biopsy (TRUS). METHODS: In total, 132 consecutive patients with TRUS-diagnosed ASAP underwent TTMB by means of an anatomic-based technique with sampling of 24 biopsy regions. For each of the 24 regions, 1-3 biopsy cores were obtained (depending on prostate size). No patient underwent pre-biopsy MRI imaging...
November 29, 2016: World Journal of Urology
https://www.readbyqxmd.com/read/27900214/are-magnetic-resonance-imaging-undetectable-prostate-tumours-clinically-significant-results-of-histopathological-analyses
#15
Kristian D Stensland, Karl Coutinho, Adele R Hobbs, Lindsay Haines, Shemille A Collingwood, Young Suk Kwon, Simon J Hall, Maria Katsigeorgis, Seyed Behzad Jazayeri, David B Samadi
OBJECTIVE: To investigate whether tumours at threshold values for detection on magnetic resonance imaging (MRI) represent clinically significant tumours or not, and therefore the utility of MRI in active surveillance (AS) protocols. PATIENTS AND METHODS: A retrospective analysis of a single institution database was performed after Institutional Review Board approval. Between 2010 and 2013, 1633 patients underwent robot-assisted laparoscopic prostatectomy (RALP) at a single institution by a single surgeon...
December 2016: Arab Journal of Urology
https://www.readbyqxmd.com/read/27900104/prostate-specific-antigen-nadir-concentration-hypertension-and-diabetes-as-risk-factors-for-biochemical-failure-after-permanent-125-i-seed-brachytherapy-for-prostate-cancer
#16
Essi Kovalainen, Markku H Vaarala
The aim of this study was to evaluate risk factors for biochemical failure (BF) following permanent prostate seed (125)I brachytherapy for prostate cancer. The study reviewed the medical records of 607 patients with biopsy-proven prostate adenocarcinoma who were treated at Oulu University Hospital between 2001 and 2014. Clinical characteristics at diagnosis, treatment-related data and follow-up data were collected to identify potential risk factors for BF, which was defined using the Phoenix criteria [prostate-specific antigen (PSA) increase >2 µg/l from the PSA nadir concentration, which defined as the lowest PSA concentration observed after BT]...
November 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27897172/adaptation-and-external-validation-of-the-european-randomised-study-of-screening-for-prostate-cancer-risk-calculator-for-the-chinese-population
#17
P K Chiu, M J Roobol, D Nieboer, J Y Teoh, S K Yuen, S M Hou, M K Yiu, C F Ng
BACKGROUND: To adapt the well-performing European Randomized Study of Screening for Prostate Cancer (ERSPC) risk calculator to the Chinese setting and perform an external validation. METHODS: The original ERSPC risk calculator 3 (RC3) for prostate cancer (PCa) and high-grade PCa (HGPCa) was applied to a development cohort of 3006 previously unscreened Hong Kong Chinese men with initial transrectal biopsies performed from 1997 to 2015, age 50-80 years, PSA 0.4-50 ng ml(-1) and prostate volume 10-150 ml...
November 29, 2016: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/27894974/ccp-score-might-improve-the-current-risk-assessment-in-newly-diagnosed-prostate-cancer-patients
#18
Marco Oderda, Gabriele Cozzi, Lorenzo Daniele, Anna Sapino, Stefania Munegato, Giuseppe Renne, Ottavio De Cobelli, Paolo Gontero
OBJECTIVE: To assess whether cell-cycle progression (CCP)-score (Prolaris) can improve the current risk assessment in newly diagnosed PCa patients. CCP-score is a well validated prognostic assay predictive of PCa death, biochemical recurrence (BCR) and progression. METHODS: We evaluated CCP-score at biopsy in 52 patients newly diagnosed with PCa who underwent radical prostatectomy. CCP-score was calculated as average RNA expression of 31 CCP genes, normalized to 15 housekeeping genes...
November 25, 2016: Urology
https://www.readbyqxmd.com/read/27893589/the-role-of-psma-pet-ct-imaging-in-restaging-of-prostate-cancer-patients-with-low-prostate-specific-antigen-levels
#19
Levent Kabasakal, Emre Demirci, Jamal Nematyazar, Reşit Akyel, Baresh Razavi, Meltem Ocak, Aslan Aygun, Can Obek, Ali R Kural
INTRODUCTION: Prostate-specific membrane antigen (PSMA) is increasingly being recognized as a novel target for the PET imaging of prostate cancer (PCa) and Ga-DKFZ-11 (Ga-PSMA) has been suggested as a novel tracer for detection of PCa relapses and metastases. The aim of this study was to evaluate the diagnostic value of PSMA PET/CT in the diagnosis of recurrent PCa with low prostate-specific antigen (PSA) levels. PATIENTS AND METHODS: We carried out a retrospective analysis of patients who underwent PSMA PET/CT from November 2013 to December 2014 in our department...
November 28, 2016: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/27891343/expression-of-alpha-methylacyl-coa-racemase-amacr-in-gastric-adenocarcinoma-and-its-correlation-with-helicobacter-pylori-infection
#20
Yamini Jindal, Anshul Singh, Ravikant Kumar, Kachnar Varma, Vatsala Misra, Sri Prakash Misra, Manisha Dwivedi
INTRODUCTION: Gastric cancer develops in a multistep progression and is determined by genetic and environmental factors. Over-expression of Alpha Methylacyl CoA Racemase (AMACR) is useful in diagnosis of prostate cancer. There is plenty of genetic alteration that occurs in gastric adenocarcinoma. The present study was planned to determine if AMACR can be used as a diagnostic marker in gastric adenocarcinoma similar to prostate cancer. AIM: To study the expression of AMACR in gastric adenocarcinoma and correlate its expression with density of Helicobacter pylori...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
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