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https://www.readbyqxmd.com/read/29220213/clinical-application-of-biparametric-mri-texture-analysis-for-detection-and-evaluation-of-high-grade-prostate-cancer-in-zone-specific-regions
#1
Xiang-Ke Niu, Zhi-Fan Chen, Lin Chen, Jun Li, Tao Peng, Xin Li
OBJECTIVE: The purpose of this study was to investigate the performance of biparametric MRI texture analysis (TA) in detecting and evaluating high-grade prostate cancer in zone-specific regions. MATERIALS AND METHODS: A retrospective study included 184 consecutively registered biopsy-naive patients in whom prostate cancer was suspected who were undergoing multiparametric prostate MRI. MR images were scored and evaluated by two readers using the Prostate Imaging Reporting and Data System version 2 (PI-RADSv2) and biparametric MRI TA in separate sessions...
December 8, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29213105/preoperative-prostate-health-index-predicts-poor-pathologic-outcomes-of-radical-prostatectomy-in-patients-with-biopsy-detected-low-risk-patients-prostate-cancer-results-from-a-chinese-prospective-cohort
#2
Bo Tang, Cheng-Tao Han, Xiao-Lin Lu, Fang-Ning Wan, Cui-Zhu Zhang, Yao Zhu, Ding-Wei Ye
OBJECTIVE: To determine the performance of the prostate health index (PHI) in predicting pathologic outcomes of radical prostatectomy (RP) in Chinese patients with low-risk prostate cancer (PCa). METHODS: Of all consecutive patients who underwent RP in one tertiary center from September 2013 to January 2017, we prospectively examined the data of 140 patients with low-risk PCa based on the Prostate Cancer Research International: Active Surveillance (PRIAS) criteria...
December 6, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29212868/painful-testicular-metastasis-from-prostate-adenocarcinoma
#3
Karla A Lee, Erik Mayer, Vincent Khoo
A 60-year-old man presented with unilateral testicular pain and urinary frequency. His presenting prostate-specific antigen (PSA) was 100 ng/mL, and a biopsy revealed Gleason 4+4 prostate adenocarcinoma. The significance of his initial PSA was somewhat complicated by possible prostatitis and early initiation of bicalutamide. PSA rose on two occasions prior to radiotherapy but coincided with a flare of testicular pain on one of these. Whole-body staging diffusion-weighted MRI scan was negative. He was treated with 3 years of androgen deprivation therapy (ADT) and radical radiotherapy...
December 5, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29212392/multi-parametric-magnetic-resonance-imaging-monitoring-patients-in-active-surveillance-for-prostate-cancer-a-prospective-cohort-study
#4
Maria Carlsen Elkjær, Morten Heebøll Andersen, Søren Høyer, Bodil Ginnerup Pedersen, Michael Borre
OBJECTIVES: To evaluate the use of multi-parametric magnetic resonance imaging (mpMRI) and mpMRI guided biopsies (MRGB) for monitoring an active surveillance (AS) prostate cancer cohort. MATERIALS AND METHODS: One year after initial diagnostic TRUS guided biopsy (TRUS-bx), baseline mpMRI, and enrolment in an AS program patients underwent a one year follow-up comprising the usual TRUS-bx and an mpMRI. Prostate MRI lesions were scored on the five-point PIRADS scale version 2...
December 7, 2017: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/29212368/impact-of-variations-in-prostatic-apex-shape-on-apical-margin-positive-rate-after-radical-prostatectomy-robot-assisted-laparoscopic-radical-prostatectomy-versus-open-radical-prostatectomy
#5
Young Dong Yu, Minseung Lee, Sung Kyu Hong, Seok-Soo Byun, Sang Eun Lee, Sangchul Lee
AIM: To evaluate the effects of prostatic apex shape variations on positive apical margin rate (PAM) after radical prostatectomy (RP) by undertaking a comparative study of robot-assisted laparoscopic radical prostatectomy (RALP) versus open radical prostatectomy (ORP). METHODS: A total 3,324 cases of RP (1,004 ORP and, 2,320 RALP) from January 2004 to March 2017 were retrospectively reviewed. All patients underwent preoperative magnetic resonance imaging (MRI) and the cohorts were stratified into 4 categories according to prostatic apical shape at the mid-sagittal plane...
December 6, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/29212276/low-circulating-levels-of-the-mitochondrial-peptide-hormone-shlp2-novel-biomarker-for-prostate-cancer-risk
#6
Jialin Xiao, Lauren Howard, Junxiang Wan, Emily Wiggins, Adriana Vidal, Pinchas Cohen, Stephen J Freedland
Context: Mitochondrial DNA mutations and dysfunction are associated with prostate cancer (PCa). Small humanin-like peptide-2 (SHLP2) is a novel mitochondrial-encoded peptide and an important mitochondrial retrograde signaling molecule. Objective: To determine whether serum SHLP2 concentration is associated with PCa risk and whether associations are race-specific.Design, Setting and Participants: Patients undergoing prostate biopsy were recruited from the Durham Veterans Affairs hospital...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29211932/targeted-versus-systematic-robot-assisted-transperineal-mri-trus-fusion-prostate-biopsy
#7
J Mischinger, S Kaufmann, G I Russo, N Harland, S Rausch, B Amend, M Scharpf, L Loewe, T Todenhoefer, M Notohamiprodjo, K Nikolaou, A Stenzl, J Bedke, S Kruck
OBJECTIVES: To evaluate the performance of transperineal robot-assisted (RA) targeted (TB) and systematic (SB) prostate biopsy in the primary and repeat biopsy setting. PATIENTS AND METHODS: Patients were admitted to RA biopsy between 2014-2016. Prior to RA-TB, multiparametric (mp) Magnetic Resonance Imaging (MRI) was performed. Prostate lesions were scored (Prostate Imaging, Reporting and Data System Version 2) and used for RA-TB planning. In addition, RA-SB was performed...
December 6, 2017: BJU International
https://www.readbyqxmd.com/read/29211405/high-intensity-focused-ultrasound-hifu-as-salvage-therapy-for-radio-recurrent-prostate-cancer-predictors-of-disease-response
#8
Shawn Dason, Nathan C Wong, Christopher B Allard, Jen Hoogenes, William Orovan, Bobby Shayegan
BACKGROUND: Some men with localized radio-recurrent prostate cancer may benefit from salvage high-intensity focused ultrasound (HIFU). Herein, we describe oncologic outcomes and predictors of disease response after salvage whole gland HIFU from our prospective cohort. MATERIALS AND METHODS: Patients with localized radio-recurrent prostate cancer were prospectively enrolled from January 2005 to December 2014. Participants had to meet both biochemical and histological definitions of recurrence...
December 7, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29211393/the-impact-of-metformin-use-on-the-risk-of-prostate-cancer-after-prostate-biopsy-in-patients-with-high-grade-intraepithelial-neoplasia
#9
Lucio Dell'Atti, Andrea B Galosi
PURPOSE: We report our experience on metformin use in diabetic patients and its impact on prostate cancer (PCa) after a high-grade prostatic intraepithelial neoplasia (HGPIN) diagnosis. MATERIALS AND METHODS: We retrospectively analyzed 551 patients with a diagnosis of HGPIN without PCa in a first prostate biopsy. The cohort of the study consisted of 456 nondiabetic subjects, and 95 diabetic patients. Among the patients with diabetes 44 were treated with metformin, and 51 with other antidiabetic drugs...
December 7, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29211357/oxidative-stress-parameters-in-patients-with-prostate-cancer-benign-prostatic-hyperplasia-and-asymptomatic-inflammatory-prostatitis-a-prospective-controlled-study
#10
Engin Kaya, Yasar Ozgok, Murat Zor, Ayse Eken, Selahattin Bedir, Onur Erdem, Turgay Ebiloglu, Giray Ergin
BACKGROUND: The imbalance between oxidant and reductant mechanisms creates a nidus for the etiopathogenesis of several diseases. In this study, we aimed to compare the oxidative stress (OS) parameters in patients who were diagnosed with prostate cancer (pCa), benign prostatic hyperplasia (BPH) or asymptomatic inflammatory prostatitis (AIP), according to the histopathologic examination of transrectal ultrasonographic prostate biopsy and transurethral prostate resection specimens. OBJECTIVES: In this study, we aimed to compare oxidative stress between histologically proven prostate cancer, hyperplasia and prostatitis...
October 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29211355/tumor-marker-%C3%AE-fetoprotein-receptor-does-not-discriminate-between-benign-prostatic-disease-and-prostate-cancer
#11
Tomaž Smrkolj, Borut Gubina, Jure Bizjak, Kristina Kumer, Teja Fabjan, Joško Osredkar
BACKGROUND: The α-fetoprotein receptor (RECAF) is a proposed novel tumor marker for detecting several different types of tumors, including prostate cancer (PCa). OBJECTIVES: The aim of the study was to evaluate RECAF in discriminating benign prostatic conditions from PCa and to compare it with prostate-specific antigen (PSA). MATERIAL AND METHODS: A total of 64 patients with elevated serum PSA levels and/or abnormal digital rectal examination of the prostate referred to a tertiary center for transrectal ultrasound (TRUS) biopsy of the prostate were prospectively enrolled in the study from January 2009 to April 2010...
October 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29211316/the-efficacy-of-prostate-specific-antigen-screening-impact-of-key-components-in-the-erspc-and-plco-trials
#12
Harry J de Koning, Roman Gulati, Sue M Moss, Jonas Hugosson, Paul F Pinsky, Christine D Berg, Anssi Auvinen, Gerald L Andriole, Monique J Roobol, E David Crawford, Vera Nelen, Maciej Kwiatkowski, Marco Zappa, Marcos Luján, Arnauld Villers, Tiago M de Carvalho, Eric J Feuer, Alex Tsodikov, Angela B Mariotto, Eveline A M Heijnsdijk, Ruth Etzioni
BACKGROUND: The European Randomized Study of Screening for Prostate Cancer (ERSPC) demonstrated that prostate-specific antigen (PSA) screening significantly reduced prostate cancer mortality (rate ratio, 0.79; 95% confidence interval, 0.69-0.91). The US Prostate, Lung, Colorectal, and Ovarian (PLCO) trial indicated no such reduction but had a wide 95% CI (rate ratio for prostate cancer mortality, 1.09; 95% CI, 0.87-1.36). Standard meta-analyses are unable to account for key differences between the trials that can impact the estimated effects of screening and the trials' point estimates...
December 6, 2017: Cancer
https://www.readbyqxmd.com/read/29206995/concordance-of-circulating-tumor-dna-and-matched-metastatic-tissue-biopsy-in-prostate-cancer
#13
Alexander W Wyatt, Matti Annala, Rahul Aggarwal, Kevin Beja, Felix Feng, Jack Youngren, Adam Foye, Paul Lloyd, Matti Nykter, Tomasz M Beer, Joshi J Alumkal, George V Thomas, Robert E Reiter, Matthew B Rettig, Christopher P Evans, Allen C Gao, Kim N Chi, Eric J Small, Martin E Gleave
Background: Real-time knowledge of the somatic genome can influence management of patients with metastatic castration-resistant prostate cancer (mCRPC). While routine metastatic tissue biopsy is challenging in mCRPC, plasma circulating tumor DNA (ctDNA) has emerged as a minimally invasive tool to sample the tumor genome. However, no systematic comparisons of matched "liquid" and "solid" biopsies have been performed that would enable ctDNA profiling to replace the need for direct tissue sampling...
December 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29206164/dietary-consumption-of-phenolic-acids-and-prostate-cancer-a-case-control-study-in-sicily-southern-italy
#14
Giorgio Ivan Russo, Daniele Campisi, Marina Di Mauro, Federica Regis, Giulio Reale, Marina Marranzano, Rosalia Ragusa, Tatiana Solinas, Massimo Madonia, Sebastiano Cimino, Giuseppe Morgia
Dietary polyphenols gained the interest of the scientific community due to their wide content in a variety of plant-derived foods and beverages commonly consumed, such as fruits, vegetables, coffee, tea, and cocoa. We aimed to investigate whether there was an association between dietary phenolic acid consumption and prostate cancer (PCa) in South Italy. We conducted a population-based case-control study from January 2015 to December 2016 in a single institution of the municipality of Catania, southern Italy (Registration number: 41/2015)...
December 5, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29205165/prevalence-of-antibiotic-resistance-in-fecal-flora-before-transrectal-ultrasound-guided-prostate-biopsy-and-the-clinical-impact-of-targeted-antibiotic-prophylaxis
#15
Arikan Ozgur, Yildirim Asif, Atis Gokhan, Tanidir Berrin, Gurbuz Cenk, Erol Bulent, Danacioglu Onur, Culpan Meftun, Vahapoglu Haluk, Caskurlu Hulya, Caskurlu Turhan
OBJECTIVES: In this study, we aimed to evaluate ciprofloxacin resistance and the presence of extended-spectrum beta-lactamase producing organisms (ESBLs) in the population of patients with indication to undergo prostate biopsy. Our additional aim was to compare the targeted antibiotic prophylaxis and sepsis rates after transrectal ultrasound guided prostate biopsy in patients who received routine ciprofloxacin prophylaxis and to evaluate the predictive factors of antibiotic resistance...
December 2017: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/29205162/multiparametric-mri-guided-biopsy-in-the-era-of-precision-medicine
#16
Miguel A Bergero, Pablo F Martínez, Jan P Radtke, Boris A Hadaschik
OBJECTIVE: Technical improvements in prostate magnetic resonance imaging (MRI) have resulted in the use of MRI to target prostate biopsy. This allowed urologists to progress from blind biopsies to target biopsies with a better performance in prostate cancer (PC) diagnosis. We herein review the current status of Magnetic Resonance Imaging Guided Biopsy (MRGB) for the detection of PC. METHODS: A systematic review of the literature was conducted using PubMed, Embase and Cochrane using the search criteria: "PC and MRI/US fusion" or "PC and guided biopsy" or "PC and multiparametric MRI" or "PC and MRI guided prostate biopsy"...
December 2017: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/29204527/outcomes-and-toxicity-of-313-prostate-cancer-patients-receiving-helical-tomotherapy-after-radical-prostatectomy
#17
Lindsay Jensen, Bertram Yuh, Jeffrey Y C Wong, Timothy Schultheiss, Jonathan Cheng, Nora Ruel, Przemyslaw Twardowski, Sagus Sampath
Purpose: There are limited long-term data on patients treated with image guided intensity modulated radiation therapy (IG-IMRT) for prostate cancer recurrence or high-risk disease features after radical prostatectomy. We report single-institution results for patients treated with IG-IMRT and identify variables associated with outcome. Methods and materials: This is a retrospective chart review consisting of 313 consecutive patients who were treated with adjuvant or salvage IG-IMRT from 2004 to 2013...
October 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29204363/suspicious-findings-on-micro-ultrasound-imaging-and-early-detection-of-prostate-cancer
#18
Sangeet Ghai, Theodorus Van der Kwast
The ExactVu™ Micro-Ultrasound system is a new high resolution imaging system for visualizing the prostate and has been FDA, CE, and Health Canada approved for visualization and biopsy of the prostate. The PRI-MUS™ (Prostate Risk Identification for Micro-Ultrasound) protocol has previously been demonstrated to correlate with risk of prostate cancer and severity of cancer. Here we present a case where a healthy 50 year old subject with no known risk factors volunteered to test the ExactVu system and was found to harbour multiple PRI-MUS 3-5 lesions...
January 2018: Urology Case Reports
https://www.readbyqxmd.com/read/29203895/baseline-prostate-atrophy-is-associated-with-lower-tumor-volume-in-men-with-prostate-cancer-on-repeat-biopsy
#19
Daniel M Moreira, Gerald L Andriole, Ramiro Castro-Santamaria, Stephen J Freedland
BACKGROUND: Prostate atrophy (PA) is commonly identified in prostate biopsies. Previous studies suggest PA may be associated with lower PCa risk. However, it remains unclear whether PA is associated with smaller, less aggressive, and less advanced tumors. Thus, we sought to determine whether the presence and severity of baseline PA in men with initial biopsy negative for prostate cancer (PCa) is associated with PCa volume at 2- and 4-year repeat biopsy. METHODS: We performed a retrospective analysis of 927 men 50-75-years-old with negative baseline biopsy and positive 2- or 4-year repeat biopsy for PCa in the Reduction by Dutasteride of PCa Events study...
December 4, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29203187/paratesticular-liposarcoma-masquerading-as-an-inguinal-hernia
#20
Kerry L Thomas, Ricardo J Gonzalez, Evita Henderson-Jackson, Jamie T Caracciolo
A man with left scrotal swelling felt to represent inguinal hernia underwent CT scan for reported bleeding after prostate biopsy. CT scan revealed a 15 cm extratesticular left scrotal mass containing both fat and soft tissue components, raising concern for dedifferentiated liposarcoma. At surgery and pathology, the mass was separate from the left testis, epididymis, and spermatic cord. Histopathologic findings were consistent with paratesticular dedifferentiated liposarcoma.
December 1, 2017: Urology
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