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https://www.readbyqxmd.com/read/28222486/accuracy-of-real-time-magnetic-resonance-imaging-transrectal-ultrasound-fusion-image-guided-transperineal-target-biopsy-with-needle-tracking-with-a-mechanical-position-encoded-stepper-in-detecting-significant-prostate-cancer-in-biopsy-na%C3%A3-ve-men
#1
Sunao Shoji, Shinichiro Hiraiwa, Takahiro Ogawa, Masayoshi Kawakami, Mayura Nakano, Kazunobu Hashida, Yoshinobu Sato, Terumitsu Hasebe, Toyoaki Uchida, Takuma Tajiri
OBJECTIVE: To evaluate the accuracy of real-time elastic fusion image-guided transperineal prostate biopsy with needle tracking involving a mechanical position-encoded stepper in detecting clinically significant prostate cancer for biopsy-naïve men. METHODS: We prospectively recruited patients with serum prostate-specific antigen levels of 4.0-20 ng/mL and suspicious of prostate cancer on multiparametric magnetic resonance imaging. They underwent targeted biopsies for cancer-suspicious lesions and 12-core systematic biopsies...
February 21, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/28222483/prevalence-and-characteristics-of-fecal-antimicrobial-resistant-escherichia-coli-in-a-cohort-of-japanese-men-undergoing-prostate-biopsy
#2
Jun Kamei, Yuka Yagihara, Haruki Kume, Takamasa Horiuchi, Tomoaki Sato, Tohru Nakagawa, Tetsuya Fujimura, Hiroshi Fukuhara, Kyoji Moriya, Yukio Homma
OBJECTIVES: To examine resistant Escherichia coli in rectal swab culture of Japanese men undergoing prostate biopsy, and to determine its prevalence, genotypic characteristics and carriage risk factors. METHODS: Rectal swabs of consecutive men undergoing transrectal ultrasound-guided prostate biopsy from April 2013 to March 2015 were cultured to isolate fluoroquinolone-resistant and extended-spectrum β-lactamase-producing E. coli. The prevalence and antimicrobial susceptibility of these resistant E...
February 21, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/28221220/impact-of-the-united-states-preventive-services-task-force-d-recommendation-on-prostate-cancer-screening-and-staging
#3
Renu S Eapen, Annika Herlemann, Samuel L Washington, Matthew R Cooperberg
PURPOSE OF REVIEW: In 2012, the United States Preventive Services Task Force (USPSTF) issued a grade 'D' recommendation against the use of routine prostate-specific antigen (PSA)-based screening for any men. This recommendation reflects critical misinterpretations of the available evidence base regarding benefits and harms of PSA screening and has influenced the nationwide landscape of prostate cancer screening, diagnosis, and treatment. RECENT FINDINGS: Following the USPSTF recommendation, a substantial decline in PSA screening was noted for all age groups...
February 17, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/28221219/improving-the-evaluation-and-diagnosis-of-clinically-significant-prostate-cancer-in-2017
#4
Sigrid V Carlsson, Monique J Roobol
PURPOSE OF REVIEW: To provide an overview of the current state of the evidence and highlight recent advances in the evaluation and diagnosis of clinically significant prostate cancer, focusing on biomarkers, risk calculators and multiparametric MRI (mpMRI). RECENT FINDINGS: In 2017 there are numerous options to improve early detection as compared to a purely prostate-specific antigen (PSA)-based approach. All have strengths and drawbacks. In addition to repeating the PSA and performing clinical work-up (digital rectal examination and estimation of prostate volume), additional tests investigated in the initial biopsy setting are: %free PSA, Prostate Health Index, 4-kallikrein score, SelectMDx, and Michigan Prostate Score and in the repeat setting: %free PSA, Prostate Health Index, 4-kallikrein score, Prostate Cancer Antigen 3, and ConfirmMDx...
February 17, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/28220802/the-prostate-cancer-prevention-trial-risk-calculator-2-0-performs-equally-for-standard-biopsy-and-mri-us-fusion-guided-biopsy
#5
M Maruf, M Fascelli, A K George, M M Siddiqui, M Kongnyuy, J M DiBianco, A Muthigi, S Valayil, A Sidana, T P Frye, A Kilchevsky, P L Choyke, B Turkbey, B J Wood, P A Pinto
BACKGROUND: The Prostate Cancer Prevention Trial Risk Calculator 2.0 (PCPTRC) is a widely used risk-based calculator used to assess a man's risk of prostate cancer (PCa) before biopsy. This risk calculator was created from data of a patient cohort undergoing a 6-core sextant biopsy, and subsequently validated in men undergoing 12-core systematic biopsy (SBx). The accuracy of the PCPTRC has not been studied in patients undergoing magnetic resonance imaging/ultrasound (MRI/US) fusion-guided biopsy (FBx)...
February 21, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28220449/current-management-strategy-for-active-surveillance-in-prostate-cancer
#6
REVIEW
Jamil S Syed, Juan Javier-Desloges, Stephanie Tatzel, Ansh Bhagat, Kevin A Nguyen, Kevin Hwang, Sarah Kim, Preston C Sprenkle
PURPOSE OF REVIEW: Active surveillance has been increasingly utilized as a strategy for the management of favorable-risk, localized prostate cancer. In this review, we describe contemporary management strategies of active surveillance, with a focus on traditional stratification schemes, new prognostic tools, and patient outcomes. RECENT FINDINGS: Patient selection, follow-up strategy, and indication for delayed intervention for active surveillance remain centered around PSA, digital rectal exam, and biopsy findings...
February 2017: Current Oncology Reports
https://www.readbyqxmd.com/read/28216939/prostatic-intraepithelial-neoplasia-like-ductal-prostatic-adenocarcinoma-a-case-suitable-for-active-surveillance
#7
Soroush Rais-Bahrami, Melissa R Dillard, Grace G Zhu, Jennifer B Gordetsky
In contrast to typical prostatic ductal adenocarcinoma, prostatic intraepithelial neoplasia (PIN)-like ductal adenocarcinoma is a rare variant of prostate cancer with low-grade clinical behavior. We report a case of a 66-year-old African-American male with an elevated serum prostate-specific antigen who underwent multiparametric prostate magnetic resonance imaging (MRI) and MRI/ultrasound fusion-guided biopsies. Pathology demonstrated low-volume Gleason score 3 + 3 = 6 (Grade Group 1), acinar adenocarcinoma involving one core and PIN-like ductal adenocarcinoma on a separate core...
January 2017: Urology Annals
https://www.readbyqxmd.com/read/28216327/combined-whole-body-and-multi-parametric-prostate-mri-as-a-single-step-approach-for-the-simultaneous-assessment-of-local-recurrence-and-metastatic-disease-after-radical-prostatectomy
#8
Nicola L Robertson, Evis Sala, Matthias Benz, Jonathan Landa, Peter Scardino, Howard I Scher, Hedvig Hricak, Hebert A Vargas
PURPOSE: To report our initial experience using "whole body and dedicated prostate (WB+P)" MRI as a single exam for the assessment of local recurrence and metastatic disease in patients with suspected recurrent prostate cancer (PCa) after radical prostatectomy (RP). MATERIALS AND METHODS: IRB-approved retrospective single-center study. 76 consecutive patients with clinically suspected recurrent PCa following RP underwent combined WB+P-MRI in a single session (10/2014-01/2016)...
February 16, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28215847/prostate-cancer-screening-in-men-aged-50-to-69-years-sthlm3-a-prospective-population-based-diagnostic-study-gr%C3%A3-nberg-h-adolfsson-j-aly-m-nordstr%C3%A3-m-t-wiklund-p-brandberg-y-thompson-j-wiklund-f-lindberg-j-clements-m-egevad-l-eklund-m-lancet-oncol-2015-dec-16
#9
Eggener Scott, J Adolfsson, M Aly, T Nordström, P Wiklund, Y Brandberg, J Thompson, F Wiklund, J Lindberg, M Clements, L Egevad, M Eklund
BACKGROUND: The prostate-specific antigen (PSA) test is used to screen for prostate cancer but has a high false-positive rate that translates into unnecessary prostate biopsies and overdiagnosis of low-risk prostate cancers. We aimed to develop and validate a model to identify high-risk prostate cancer (with a Gleason score of at least 7) with better test characteristics than that provided by PSA screening alone. METHODS: The Stockholm 3 (STHLM3) study is a prospective, population-based, paired, screen-positive, diagnostic study of men without prostate cancer aged 50 to 69 years randomly invited by date of birth from the Swedish Population Register kept by the Swedish Tax Agency...
March 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28213918/editorial-comment-to-biopsy-undergrading-in-men-with-gleason-score-6-and-fatal-prostate-cancer-in-the-european-randomized-study-of-screening-for-prostate-cancer-rotterdam
#10
Lars Egevad, Hemamali Samaratunga, Brett Delahunt
No abstract text is available yet for this article.
February 17, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/28212371/circulating-tumor-cells-in-prostate-cancer-beyond-enumeration
#11
Jie-Fu Chen, Yi-Tsung Lu, Shirley Cheng, Hsian-Rong Tseng, Robert A Figlin, Edwin M Posadas
Circulating tumor cells (CTCs) are a population of rare cancer cells that have detached from the primary tumor and/or metastatic lesions and entered the peripheral circulation. Enumeration of CTCs has demonstrated value as a prognostic biomarker, and newer studies have pointed to information beyond enumeration that is of critical importance in prostate cancer. Technologic advances that permit examination of the morphology, function, and molecular content of CTCs have made it possible to measure these factors as part of liquid biopsy...
January 2017: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/28212119/the-role-of-biomarkers-in-undiagnosed-men
#12
Hasan Dani, Stacy Loeb
PURPOSE OF REVIEW: This article intends to review biomarkers derived from blood, urine, and tissue that can aid in the diagnosis of prostate cancer (PCa). RECENT FINDINGS: PCa screening requires tools that complement prostate-specific antigen (PSA) with a higher specificity for clinically significant disease. Novel blood biomarkers, such as the Prostate Health Index (phi) and 4Kscore, utilize isoforms of PSA to more accurately predict high-grade PCa than traditional tools such as PSA and the percentage free-to-total PSA...
February 16, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/28211531/proteomic-analysis-of-urinary-extracellular-vesicles-from-high-gleason-score-prostate-cancer
#13
Kazutoshi Fujita, Hideaki Kume, Kyosuke Matsuzaki, Atsunari Kawashima, Takeshi Ujike, Akira Nagahara, Motohide Uemura, Yasushi Miyagawa, Takeshi Tomonaga, Norio Nonomura
Extracellular vesicles (EVs) are microvesicles secreted from various cell types. We aimed to discover a new biomarker for high Gleason score (GS) prostate cancer (PCa) in urinary EVs via quantitative proteomics. EVs were isolated from urine after massage from 18 men (negative biopsy [n = 6], GS 6 PCa [n = 6], or GS 8-9 PCa [n = 6]). EV proteins were labeled with iTRAQ and analyzed by LC-MS/MS. We identified 4710 proteins and quantified 3528 proteins in the urinary EVs. Eleven proteins increased in patients with PCa compared to those with negative biopsy (ratio >1...
February 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28209461/prostate-cancer-detection-rate-in-indonesian-men
#14
Chaidir Arif Mochtar, Widi Atmoko, Rainy Umbas, Agus Rizal Ardy Hariandy Hamid
PURPOSES OF THE STUDY: To evaluate the overall detection rate of prostate cancer in biopsies according to serum prostate-specific antigen levels, determine the number of cores biopsied in Indonesian men, and provide a correlated staging of prostate cancer patients at varying intervals of prostate-specific antigen levels. METHODS: We retrospectively analyzed the data from Indonesian men who had undergone prostate biopsy at two national referral medical centers in Jakarta from January 1995 to December 2014...
February 13, 2017: Asian Journal of Surgery
https://www.readbyqxmd.com/read/28207981/a-multiparametric-magnetic-resonance-imaging-based-risk-model-to-determine-the-risk-of-significant-prostate-cancer-prior-to-biopsy
#15
Pim J van Leeuwen, Andrew Hayen, James E Thompson, Daniel Moses, Ron Shnier, Maret Böhm, Magdaline Abuodha, Anne-Maree Haynes, Francis Ting, Jelle Barentsz, Monique Roobol, Justin Vass, Krishan Rasiah, Warick Delprado, Phillip D Stricker
OBJECTIVES: To develop and externally validate a predictive model for detection of significant prostate cancer (PC). SUBJECTS AND METHODS: Development of the model was based on prospective cohort including 393 men who underwent mpMRI prior to biopsy. External validity of the model was then examined retrospectively in 198 men from a separate institution whom underwent a mpMRI followed by biopsy for abnormal PSA/DRE. A model was developed with age, PSA, DRE, prostate volume, previous biopsy and PIRADS score as predictors for significant PC (Gleason 7 with >5% grade 4, ≥ 20% cores positive or ≥ 7mm of PC in any core)...
February 16, 2017: BJU International
https://www.readbyqxmd.com/read/28202223/filtration-based-enrichment-of-circulating-tumor-cells-from-all-prostate-cancer-risk-groups
#16
Julius Adebayo Awe, Jeff Saranchuk, Darrel Drachenberg, Sabine Mai
OBJECTIVE: To combine circulating tumor cell (CTC) isolation by filtration and immunohistochemistry to investigate the presence of CTCs in low, intermediate, and high-risk prostate cancer (PCa). CTCs isolated from these risk groups stained positive for both cytokeratin and androgen receptors, but negative for CD45. PATIENTS AND METHODS: Blood samples from 41 biopsy confirmed patients with PCa at different clinical stages such as low, intermediate, and high risk were analyzed...
February 12, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28196759/follow-up-mr-imaging-of-pi-rads-3-and-pi-rads-4-prostate-lesions
#17
Elke Hauth, Horst Jaeger, Horst Hohmuth, Meinrad Beer
OBJECTIVE: To determine the rate of malignancy after follow-up MR imaging of the prostate in PI-RADS 3 lesions without core biopsy and PI-RADS 4 lesions after negative initial core biopsy. MATERIALS AND METHODS: We performed follow-up MRI in 46/72 (64%) patients with PI-RADS 3 lesions and 26/72 (36%) patients with PI-RADS 4 lesions in baseline MRI. RESULTS: The rate of malignancy in PI-RADS 3 lesions was 4% (2/46) and in PI-RADS 4 lesions 69% (18/26)...
January 30, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/28196723/diagnostic-performance-of-prostate-imaging-reporting-and-data-system-version-2-for-detection-of-prostate-cancer-a-systematic-review-and-diagnostic-meta-analysis
#18
REVIEW
Sungmin Woo, Chong Hyun Suh, Sang Youn Kim, Jeong Yeon Cho, Seung Hyup Kim
CONTEXT: In 2015, the updated Prostate Imaging Reporting and Data System version 2 (PI-RADSv2) for the detection of prostate cancer (PCa) was established. Since then, several studies assessing the value of PI-RADSv2 have been published. OBJECTIVE: To review the diagnostic performance of PI-RADSv2 for the detection of PCa. EVIDENCE ACQUISITION: MEDLINE and EMBASE databases were searched up to December 7, 2016. We included diagnostic accuracy studies that used PI-RADSv2 for PCa detection, using prostatectomy or biopsy as the reference standard...
February 11, 2017: European Urology
https://www.readbyqxmd.com/read/28196367/clinical-factors-predicting-tumour-upgrading-in-patients-under-active-surveillance-and-elected-to-active-treatment-after-disease-reclassification-or-progression
#19
Antonio Benito Porcaro, Francesca Cavicchioli, Nicolò De Luyk, Daniele Mattevi, Paolo Corsi, Marco Sebben, Alessandro Tafuri, Tania Processali, Davide Inverardi, Giovanni Cacciamani, Davide De Marchi, Matteo Balzarro, Maria A Cerruto, Matteo Brunelli, Giovanni Novella, Salvatore Siracusano, Walter Artibani
OBJECTIVES: To evaluate clinical factors associated with tumour upgrading (UPG) in low-intermediate risk patients who progressed while under active surveillance (AS) and underwent delayed radical prostatectomy. MATERIAL AND METHODS: The evaluated factors included prostate specific antigen (PSA), prostate volume, PSA density and number of biopsy positive cores (BPC). Multivariate logistic regression by the forward step Wald procedure was used. RESULTS: The study evaluated 24 patients who had UPG in 13 cases (54...
February 14, 2017: Urologia Internationalis
https://www.readbyqxmd.com/read/28192761/a-comparison-of-bayesian-and-non-linear-regression-methods-for-robust-estimation-of-pharmacokinetics-in-dce-mri-and-how-it-affects-cancer-diagnosis
#20
Nikolaos Dikaios, David Atkinson, Chiara Tudisca, Pierpaolo Purpura, Martin Forster, Hashim Ahmed, Timothy Beale, Mark Emberton, Shonit Punwani
The aim of this work is to compare Bayesian Inference for nonlinear models with commonly used traditional non-linear regression (NR) algorithms for estimating tracer kinetics in Dynamic Contrast Enhanced Magnetic Resonance Imaging (DCE-MRI). The algorithms are compared in terms of accuracy, and reproducibility under different initialization settings. Further it is investigated how a more robust estimation of tracer kinetics affects cancer diagnosis. The derived tracer kinetics from the Bayesian algorithm were validated against traditional NR algorithms (i...
February 5, 2017: Computerized Medical Imaging and Graphics: the Official Journal of the Computerized Medical Imaging Society
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