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https://www.readbyqxmd.com/read/28086888/non-rigid-mr-trus-image-registration-for-image-guided-prostate-biopsy-using-correlation-ratio-based-mutual-information
#1
Lun Gong, Haifeng Wang, Chengtao Peng, Yakang Dai, Min Ding, Yinghao Sun, Xiaodong Yang, Jian Zheng
BACKGROUND: To improve the accuracy of ultrasound-guided biopsy of the prostate, the non-rigid registration of magnetic resonance (MR) images onto transrectal ultrasound (TRUS) images has gained increasing attention. Mutual information (MI) is a widely used similarity criterion in MR-TRUS image registration. However, the use of MI has been challenged because of intensity distortion, noise and down-sampling. Hence, we need to improve the MI measure to get better registration effect. METHODS: We present a novel two-dimensional non-rigid MR-TRUS registration algorithm that uses correlation ratio-based mutual information (CRMI) as the similarity criterion...
January 10, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28086856/the-addition-of-a-sagittal-image-fusion-improves-the-prostate-cancer-detection-in-a-sensor-based-mri-ultrasound-fusion-guided-targeted-biopsy
#2
Karsten Günzel, Hannes Cash, John Buckendahl, Maximilian Königbauer, Patrick Asbach, Matthias Haas, Jörg Neymeyer, Stefan Hinz, Kurt Miller, Carsten Kempkensteffen
BACKGROUND: To explore the diagnostic benefit of an additional image fusion of the sagittal plane in addition to the standard axial image fusion, using a sensor-based MRI/US fusion platform. METHODS: During July 2013 and September 2015, 251 patients with at least one suspicious lesion on mpMRI (rated by PI-RADS) were included into the analysis. All patients underwent MRI/US targeted biopsy (TB) in combination with a 10 core systematic prostate biopsy (SB). All biopsies were performed on a sensor-based fusion system...
January 13, 2017: BMC Urology
https://www.readbyqxmd.com/read/28081259/frequency-of-propionibacterium-acnes-infection-in-prostate-glands-with-negative-biopsy-results-is-an-independent-risk-factor-for-prostate-cancer-in-patients-with-increased-serum-psa-titers
#3
Tomoya Kakegawa, Yuan Bae, Takashi Ito, Keisuke Uchida, Masaki Sekine, Yutaka Nakajima, Asuka Furukawa, Yoshimi Suzuki, Jiro Kumagai, Takumi Akashi, Yoshinobu Eishi
BACKGROUND: Propionibacterium acnes has recently been implicated as a cause of chronic prostatitis and this commensal bacterium may be linked to prostate carcinogenesis. The occurrence of intracellular P. acnes infection in prostate glands and the higher frequency of P. acnes-positive glands in radical prostatectomy specimens from patients with prostate cancer (PCa) than in those from patients without PCa led us to examine whether the P. acnes-positive gland frequency can be used to assess the risk for PCa in patients whose first prostate biopsy, performed due to an increased prostate-specific antigen (PSA) titer, was negative...
2017: PloS One
https://www.readbyqxmd.com/read/28079154/local-anesthesia-for-transrectal-ultrasound-guided-biopsy-of-the-prostate-a-meta-analysis
#4
Mingchao Li, Zhengyun Wang, Hao Li, Jun Yang, Ke Rao, Tao Wang, Shaogang Wang, Jihong Liu
A meta-analysis was performed to evaluate the efficacy of local anesthesia in alleviating pain during prostate biopsy. We searched relevant articles in PubMed and Embase. The included studies should be randomized controlled trials (RCT) using local anesthesia to alleviate pain during biopsy, which was recorded by a pain scale. Analgesic efficacy of different local anesthesia techniques were analyzed, including intrarectal local anesthesia (IRLA), periprostatic nerve block (PNB), pelvic plexus block (PPB) and intraprostatic local anesthesia (IPLA)...
January 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28077413/cancer-related-hospitalisations-and-unknown-stage-prostate-cancer-a-population-based-record-linkage-study
#5
Qingwei Luo, Xue Qin Yu, David Paul Smith, David Eamon Goldsbury, Claire Cooke-Yarborough, Manish Indravadan Patel, Dianne Lesley O'Connell
OBJECTIVES: To identify reasons for prostate cancer stage being recorded as 'unknown' in Australia's largest population-based cancer registry. DESIGN: Prospective population-based cohort. SETTING: New South Wales (NSW) is the most populous state in Australia, with almost one third of the total national population. PARTICIPANTS: NSW Cancer Registry (NSWCR) records for prostate cancer cases diagnosed in 2001-2009 were linked to the NSW Admitted Patient Data Collection (APDC) for 2000-2010...
January 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28076331/a-short-term-intervention-with-selenium-affects-expression-of-genes-implicated-in-the-epithelial-to-mesenchymal-transition-in-the-prostate
#6
Dieuwertje E G Kok, Lambertus A L M Kiemeney, Gerald W Verhaegh, Jack A Schalken, Emile N J T van Lin, J P Michiel Sedelaar, J Alfred Witjes, Christina A Hulsbergen-van de Kaa, Pieter Van't Veer, Ellen Kampman, Lydia A Afman
In parallel with the inconsistency in observational studies and chemoprevention trials, the mechanisms by which selenium affects prostate cancer risk have not been elucidated. We conducted a randomized, placebo-controlled trial to examine the effects of a short-term intervention with selenium on gene expression in non-malignant prostate tissue. Twenty-three men received 300 µg selenium per day in the form of selenized yeast (n=12) or a placebo (n=11) during 5 weeks. Prostate biopsies collected from the transition zone before and after intervention were analysed for 15 participants (n=8 selenium, n=7 placebo)...
January 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28075651/imaging-characteristics-of-prostate-cancer-patients-who-discontinued-active-surveillance-on-3-t-multiparametric-prostate-mri
#7
David J Habibian, Corinne C Liu, Alex Dao, Kaitlin E Kosinski, Aaron E Katz
OBJECTIVE: Early-stage prostate cancer may be followed with active surveillance to avoid overtreatment. Our institution's active surveillance regimen uses annual MRI in place of serial biopsies, and biopsies are performed only when clinically necessary. The objective of our study was to report the multiparametric MRI characteristics of prostate cancer patients who discontinued active surveillance at our institution after repeat imaging revealed possible evidence of tumor upgrading. MATERIALS AND METHODS: The Department of Urology at Winthrop University Hospital prospectively maintains a database of prostate cancer patients who are monitored with active surveillance...
January 11, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28074780/mri-directed-cognitive-fusion-guided-biopsy-of-the-anterior-prostate-tumors
#8
Ian G Murphy, Elaine NiMhurchu, Robert G Gibney, Colm J McMahon
PURPOSE: We aimed to evaluate the efficacy of magnetic resonance imaging (MRI)-directed cognitive fusion transrectal ultrasonography (TRUS)-guided anterior prostate biopsy for diagnosis of anterior prostate tumors and to illustrate this technique. METHODS: A total of 39 patients with previous negative TRUS biopsy, but high clinical suspicion of occult prostate cancer, prospectively underwent prostate MRI including diffusion-weighted imaging (DWI). Patients with a suspicious anterior lesion on MRI underwent targeted anterior gland TRUS guided biopsy with cognitive fusion technique using sagittal probe orientation...
January 11, 2017: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/28073212/ultrasound-features-of-a-metastatic-seminal-vesicle-melanoma-a-case-report
#9
Andrea Fabiani, Emanuele Principi, Alessandra Filosa, Fabrizio Fioretti, Valentina Maurelli, Lucilla Servi, Gabriele Mammana
In this report we describe what we consider to be the second case of seminal vescicle (SV) metastasis from an unknown primary melanoma. only presenting symptom was a palpable firm nodule of the right prostate base on digital rectal examination (DRE). The diagnosis, after prostatic transrectal ultrasound examination (TRUS), was performed by ultrasound guided biopsy. We underline that prostatic TRUS evaluation is mandatory in case of abnormal digital rectal examination. Seminal vesicle must be always evaluated...
December 30, 2016: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/28073199/transrectal-ultrasound-trus-guided-prostate-biopsy-three-different-types-of-local-anesthesia
#10
Giuseppina Anastasi, Enrica Subba, Rosa Pappalardo, Luciano Macchione, Gioacchino Ricotta, Graziella Muscarà, Francesco Lembo, Carlo Magno
: Transrectal Ultrasound (TRUS) guided prostate biopsy is regarded as the gold standard for prostate cancer diagnosis. The majority of patients perceive TRUS-guided prostate biopsy as a physically and psychologically traumatic experience. We aimed to compare in this paper the efficacy of three different anesthesia techniques to control the pain during the procedure. MATERIALS AND METHODS: 150 patients who underwent transrectal ultrasound (TRUS) guided prostate biopsy were randomly divided into three groups...
December 30, 2016: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/28073198/prostatic-calculi-detected-in-peripheral-zone-of-the-gland-during-a-transrectal-ultrasound-biopsy-can-be-significant-predictors-of-prostate-cancer
#11
Lucio Dell'Atti, Andrea B Galosi, Carmelo Ippolito
PURPOSE: Prostatic calculi (PC) are usually associated with benign prostatic hyperplasia or chronic inflammation. However, in several studies prostatic inflammation and calcification have been implicated in the pathogenesis of prostate cancer (CaP). We evaluated the prevalence of PC during transrectal ultrasound (TRUS) and correlate the ultrasonographic patterns with histological findings. METHODS: A prospective study of 664 patients undergoing TRUS and prostate biopsy was planned...
December 30, 2016: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/28073197/detection-rate-for-significant-cancer-at-confirmatory-biopsy-in-men-enrolled-in-active-surveillance-protocol-20-cores-vs-30-cores-vs-mri-trus-fusion-prostate-biopsy
#12
Pietro Pepe, Sebastiano Cimino, Antonio Garufi, Giandomenico Priolo, Giorgio Ivan Russo, Raimondo Giardina, Giulio Reale, Michele Barbera, Paolo Panella, Michele Pennisi, Giuseppe Morgia
INTRODUCTION: The detection rate for significant prostate cancer of extended vs saturation vs mMRI/TRUS fusion biopsy was prospectively evaluated in men enrolled in active surveillance (AS) protocol. Mterials and methods: From May 2013 to September 2016 75 men aged 66 years (median) with very low risk PCa were enrolled in an AS protocol and elegible criteria were: life expectancy greater than 10 years, cT1C, PSA below 10 ng/ml, PSA density < 0.20, 2 < unilateral positive biopsy cores, Gleason score (GS) equal to 6, greatest percentage of cancer (GPC) in a core < 50%...
December 30, 2016: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/28073196/mri-us-fusion-prostate-biopsy-our-initial-experience
#13
Vito Lacetera, Bernardo Cervelli, Antonio Cicetti, Giuliana Gabrielloni, Michele Montesi, Roberto Morcellini, Gianni Parri, Emilio Recanatini, Gianluca Giglioni, Andrea Benedetto Galosi, Valerio Beatrici
AIM: The objective of this study is to present our initial experience with magnetic resonance imaging/ultrasound (MRI/US) fusion biopsy using the Koelis Trinity device after the first consecutive 59 patients. MATERIALS AND METHODS: 59 consecutive patients with suspected prostate cancer (PCA) underwent prostate biopsy using Trinity Koelis® (Koelis, Grenoble, France). We divided the patients into 2 groups: patients with a previous negative mapping underwent to a MRI/US fusion re-biopsy (Group A); and biopsy-naïve patients who underwent to a first stereotactic 3-D mapping of the prostate (Group B)...
December 30, 2016: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/28073195/cognitive-zonal-fusion-biopsy-of-the-prostate-original-technique-between-target-and-saturation
#14
Andrea B Galosi, Guevar Maselli, Giulia Sbrollini, Gaetano Donatelli, Lorenzo Montesi, Matteo Tallè, Rodolfo Montironi
: We describe our experience in prostate biopsy using a new standardized cognitive fusion techniques, that we call "cognitive zonal fusion biopsy". This new technique is based on two operative options: the first based on target biopsies, the Cognitive Target Biopsy (CTB) if the same target was detected with transrectal ultrasound (TRUS) and multiparametric magnetic resonance (mpMRI); the second based on saturation biopsies, the Zonal Saturation Biopsy (ZSB) on anatomical zone/s containing the region of interest if the same target was not evident with TRUS and MRI...
December 30, 2016: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/28071673/prognostic-value-of-the-new-grade-groups-in-prostate-cancer-a-multi-institutional-european-validation-study
#15
R Mathieu, M Moschini, B Beyer, K M Gust, T Seisen, A Briganti, P Karakiewicz, C Seitz, L Salomon, A de la Taille, M Rouprêt, M Graefen, S F Shariat
BACKGROUND: We aimed to assess the prognostic relevance of the new Grade Groups in Prostate Cancer (PCa) within a large cohort of European men treated with radical prostatectomy (RP). METHODS: Data from 27 122 patients treated with RP at seven European centers were analyzed. We investigated the prognostic performance of the new Grade Groups (based on Gleason score 3+3, 3+4, 4+3, 8 and 9-10) on biopsy and RP specimen, adjusted for established clinical and pathological characteristics...
January 10, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28069159/developing-a-new-pi-rads-v2-based-nomogram-for-forecasting-high-grade-prostate-cancer
#16
X-K Niu, W-F He, Y Zhang, S K Das, J Li, Y Xiong, Y-H Wang
AIM: To establish a predictive nomogram for high-grade prostate cancer (HGPCa) in biopsy-naive patients based on the Prostate Imaging-Reporting and Data System version 2 (PI-RADS v2), magnetic resonance imaging (MRI)-based prostate volume (PV), MRI-based PV-adjusted prostate-specific antigen density (PSAD), and other classical parameters. MATERIAL AND METHODS: Between August 2014 and August 2015, 158 men who were eligible for analysis were included as the training cohort...
January 6, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28068243/sentinel-lymph-node-dissection-to-select-clinically-node-negative-prostate-cancer-patients-for-pelvic-radiation-therapy-effect-on-biochemical-recurrence-and-systemic-progression
#17
Nikolaos Grivas, Esther Wit, Floris Pos, Jeroen de Jong, Erik Vegt, Axel Bex, Kees Hendricksen, Simon Horenblas, Gijs KleinJan, Bas van Rhijn, Henk van der Poel
PURPOSE: To assess the efficacy of robotic-assisted laparoscopic sentinel lymph node (SLN) dissection (SLND) to select those patients with prostate cancer (PCa) who would benefit from additional pelvic external beam radiation therapy and long-term androgen deprivation therapy (ADT). METHODS AND MATERIALS: Radioisotope-guided SLND was performed in 224 clinically node-negative patients scheduled to undergo external beam radiation therapy. Patients with histologically positive SLNs (pN1) were also offered radiation therapy to the pelvic lymph nodes, combined with 3 years of ADT...
February 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28063613/why-and-where-do-we-miss-significant-prostate-cancer-with-multi-parametric-magnetic-resonance-imaging-followed-by-magnetic-resonance-guided-and-transrectal-ultrasound-guided-biopsy-in-biopsy-na%C3%A3-ve-men
#18
Martijn G Schouten, Marloes van der Leest, Morgan Pokorny, Martijn Hoogenboom, Jelle O Barentsz, Les C Thompson, Jurgen J Fütterer
BACKGROUND: Knowledge of significant prostate (sPCa) locations being missed with magnetic resonance (MR)- and transrectal ultrasound (TRUS)-guided biopsy (Bx) may help to improve these techniques. OBJECTIVE: To identify the location of sPCa lesions being missed with MR- and TRUS-Bx. DESIGN, SETTING, AND PARTICIPANTS: In a referral center, 223 consecutive Bx-naive men with elevated prostate specific antigen level and/or abnormal digital rectal examination were included...
January 4, 2017: European Urology
https://www.readbyqxmd.com/read/28063603/prostate-specific-membrane-antigen-targeted-ligand-positron-emission-tomography-computed-tomography-and-immunohistochemical-findings-in-a-patient-with-synchronous-metastatic-penile-and-prostate-cancer
#19
Michael Froehner, Friederike Kuithan, Klaus Zöphel, Ulrike Heberling, Michael Laniado, Manfred P Wirth
A 68-year-old man presented with synchronous metastatic penile and prostate cancer. 68Ga-labeled prostate-specific membrane antigen-targeted ligand positron emission tomography/computed tomography (PSMA-PET/CT) revealed tracer uptake in inguinal, pelvic, and retroperitoneal metastases. Lymph node biopsies and immunohistochemical staining revealed that both cancers involved the lymph nodes and expressed PSMA. In the deposits of penile squamous cell carcinoma, PSMA expression was seen in tumor vessels and may explain the PSMA-PET/CT positivity of inguinal nodes involved in squamous cell carcinoma...
January 4, 2017: Urology
https://www.readbyqxmd.com/read/28058847/focal-signet-ring-cell-high-grade-prostatic-intraepithelial-neoplasia-on-needle-biopsy
#20
Guang-Qian Xiao, Pamela D Unger
Signet ring cell prostatic intraepithelial neoplasia is a rare speculated variant of high-grade prostatic intraepithelial neoplasia (HGPIN). Here, we present a free-standing and isolated signet ring cell HGPIN that was not associated with invasive carcinoma on needle biopsy and demonstrated the existence of this type of HGPIN variant. The differentiation between HGPIN and intraductal carcinoma of prostate is also discussed.
December 1, 2016: International Journal of Surgical Pathology
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