keyword
MENU ▼
Read by QxMD icon Read
search

HFD

keyword
https://www.readbyqxmd.com/read/29334669/anti-obesity-effects-of-clausena-excavata-in-high-fat-diet-induced-obese-mice
#1
Young-Rak Cho, Jung A Lee, Yoon Yeon Kim, Jae-Shin Kang, Jae-Ho Lee, Eun-Kyung Ahn
Clausena excavata (C. excavata) has been used as a traditional medicine for the treatment of abdominal pain, enteritis, dysentery, and malaria. The present study was designed to evaluate the effect of a 50% ethanol extract of C. excavata (ECE) on weight loss, adipocyte size, and obesity-related biochemical parameters in high-fat diet (HFD)-induced obese mice. After 6 weeks of HFD + ECE administration, HFD-induced total fat, subcutaneous fat, and visceral fat were evaluated by micro-computed tomography. The serum levels of triglyceride (TG), total cholesterol (TCH), high-density lipoprotein (HDL) cholesterol, and low-density lipoprotein (LDL) cholesterol were evaluated with a biochemical analyzer, and leptin and adiponectin levels in the serum were assessed via enzyme-linked immunoassay (ELISA)...
January 12, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29334664/methyl-dehydroabietate-counters-high-fat-diet-induced-insulin-resistance-and-hepatic-steatosis-by-modulating-peroxisome-proliferator-activated-receptor-signaling-in-mice
#2
Hiroki Yoshioka, Yuki Mizuno, Tomohiro Yamaguchi, Yoshimi Ichimaru, Koichi Takeya, Yukio Hitotsuyanagi, Tsunemasa Nonogaki, Yutaka Aoyagi
The aim of this study was to investigate the therapeutic effects of methyl dehydroabietate (mDA) on adipocyte differentiation in 3T3-L1 preadipocytes and obesity characteristics induced by high-fat diet (HFD) in mice. Adipocyte differentiation in 3T3-L1 cells was evaluated after 14 days of incubation with mDA. mDA enhanced adipocyte differentiation in 3T3-L1 cells. For the in vivo evaluation, five-week-old male C57BL/6J mice were fed HFD or normal CE-2 diet (control) for eight weeks. During the experimental period, mice were administered mDA (50 mg/kg, p...
January 12, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29333380/anti-obesity-property-of-lichen-thamnolia-vermicularis-extract-in-3t3-l1-cells-and-diet-induced-obese-mice
#3
Ra-Yeong Choi, Ju Ri Ham, Jiyoung Yeo, Jae-Seoun Hur, Seok-Kyu Park, Myung-Joo Kim, Mi-Kyung Lee
Thamnolia vermicularis (TV) is an edible lichen that is prevalent in the alpine zone of East Asia. This study evaluated the feasibility of using TV acetone extracts as a functional food based on experiments using cell line and obese mice. The cellular triglyceride levels and Oil red O staining of 3T3-L1 cells indicated that TV extracts (5 and 10 μg/mL) dose-dependently suppressed adipocyte differentiation and lipid accumulation compared with the control. The TV extract (0.4%, w/w) in a high-fat diet (HFD) was supplemented to C57BL/6N mice for 12 weeks, and TV extract supplement significantly reduced visceral fat mass and body weight compared with HFD feeding alone...
December 2017: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/29331535/estrogen-deprivation-aggravates-cardiometabolic-dysfunction-in-obese-insulin-resistant-rats-through-the-impairment-of-cardiac-mitochondrial-dynamics
#4
Wanitchaya Minta, Siripong Palee, Duangkamol Mantor, Wissuta Sutham, Thidarat Jaiwongkum, Sasiwan Kerdpoo, Wasana Pratchayasakul, Sirinart Kumfu, Siriporn C Chattipakorn, Nipon Chattipakorn
The incidence of cardiovascular disease and metabolic syndrome increases after the onset of menopause, suggesting estrogen has a vital role in their prevention. Mitochondrial dynamics are known to play an important role in the maintenance of cardiac physiological function. However, the effects of estrogen deprivation on cardiometabolic status and cardiac mitochondrial dynamics under conditions of obese-insulin resistance have never been investigated. We hypothesized that estrogen deprivation aggravates cardiac dysfunction through increased cardiac mitochondrial fission in obese-insulin resistant rats...
January 10, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29331532/high-fat-diet-mediates-anxiolytic-like-behaviors-in-a-time-dependent-manner-through-the-regulation-of-sirt1-in-the-brain
#5
Liu Xu, Shuang Xu, Lifang Lin, Xi Gu, Congcong Fu, Yingying Fang, Xiaowen Li, Xuemin Wang
The consumption of a high-fat diet (HFD) and obesity have been associated not only with metabolic diseases but also with neuropsychiatric diseases, such as depression and anxiety. However, results on the effects of an HFD on anxiety are controversial, since both anxiogenic and anxiolytic effects have been reported. In this study, we evaluated the effects of both short- and long-term intake of an HFD on anxiety-like behaviors. To explore the impact of time on the association between an HFD and anxiety, mice were fed with an HFD for 4 weeks or 12 weeks...
January 10, 2018: Neuroscience
https://www.readbyqxmd.com/read/29330433/effect-of-atorvastatin-on-the-gut-microbiota-of-high-fat-diet-induced-hypercholesterolemic-rats
#6
Tariq Jamal Khan, Youssri M Ahmed, Mazin A Zamzami, Saleh A Mohamed, Imran Khan, Othman A S Baothman, Mohamed G Mehanna, Muhammad Yasir
The aim of the present study was to investigate alterations in gut microbiota associated with hypercholesterolemia and treatment with atorvastatin, a commonly prescribed cholesterol-lowering drug. In this study, seven experimental groups of rats were developed based on diets [high-fat diet (HFD) and normal chow diet (NCD)] and various doses of atorvastatin in HFD and NCD groups. 16S rRNA amplicon sequencing was used to analyze the gut microbiota. Atorvastatin significantly reduced the cholesterol level in treated rats...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29330372/non-estrogenic-xanthohumol-derivatives-mitigate-insulin-resistance-and-cognitive-impairment-in-high-fat-diet-induced-obese-mice
#7
Cristobal L Miranda, Lance A Johnson, Oriane de Montgolfier, Valerie D Elias, Lea S Ullrich, Joshua J Hay, Ines L Paraiso, Jaewoo Choi, Ralph L Reed, Johana S Revel, Chrissa Kioussi, Gerd Bobe, Urszula T Iwaniec, Russell T Turner, Benita S Katzenellenbogen, John A Katzenellenbogen, Paul R Blakemore, Adrian F Gombart, Claudia S Maier, Jacob Raber, Jan F Stevens
Xanthohumol (XN), a prenylated flavonoid from hops, improves dysfunctional glucose and lipid metabolism in animal models of metabolic syndrome (MetS). However, its metabolic transformation into the estrogenic metabolite, 8-prenylnaringenin (8-PN), poses a potential health concern for its use in humans. To address this concern, we evaluated two hydrogenated derivatives, α,β-dihydro-XN (DXN) and tetrahydro-XN (TXN), which showed negligible affinity for estrogen receptors α and β, and which cannot be metabolically converted into 8-PN...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29327229/leopoldia-comosa-prevents-metabolic-disorders-in-rats-with-high-fat-diet-induced-obesity
#8
T Casacchia, F Scavello, C Rocca, M C Granieri, G Beretta, D Amelio, F Gelmini, A Spena, R Mazza, C C Toma, Tommaso Angelone, Giancarlo Statti, T Pasqua
PURPOSE: Obesity is the main feature of a complex illness known as metabolic syndrome. Anti-obesogenic therapies are often associated with side effects and represent a high cost in conventional pharmacological approaches. New strategies based on natural remedies are under continuous investigation. Leopoldia comosa (L.) Parl. (L. comosa) is a spontaneous plant with diuretic, anti-inflammatory and antioxidant properties. Recently, a hypoglycemic activity mediated by inhibition of carbohydrate digestion has been identified...
January 11, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29326489/ondansetron-ameliorates-depression-associated-with-obesity-in-high-fat-diet-fed-experimental-mice-an-investigation-based-on-the-behavioral-biochemical-and-molecular-approach
#9
Yeshwant Kurhe, Radhakrishnan Mahesh
INTRODUCTION: Obesity is an important risk factor for depression as more than half of the obese population is susceptible for depression at double rate. Our earlier studies reported the antidepressant potential of 5-HT3 receptor antagonist, ondansetron (OND) in depression associated obesity using behavioral tasks. The present research work is aimed to evaluate the effect of OND on depression associated with obesity with special emphasis on biochemical and molecular mechanisms such as hippocampal brain-derived neurotrophic factor (BDNF), cyclic adenosine monophosphate (cAMP), 5-hydroxytryptamine (5-HT), hippocampal histological examination and immunohistochemical expression of p53 proteins...
July 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/29325294/-effects-of-lactobacillus-paracasei-n1115-combined-with-fructooligosaccharides-on-non-alcoholic-fatty-liver-disease-induced-by-high-fat-diet-in-mice
#10
F F Yao, P Y Zheng, H Huang, L M Bai, Y R Ding, L Mei, S M Liu
Objective: To investigate the effects of Lactobacillus paracasei N1115 combined with fructooligosaccharides (FOS) on non-alcoholic fatty liver disease (NAFLD) in mice and its possible mechanism. Methods: A total of 50 male C57 mice were randomly and equally divided into five experimental groups. Group 1 received a normal diet (ND). Other four groups received a high-fat diet (HFD) to establish NAFLD models. In addition to HFD, group 3 received Lactobacillus paracasei N1115 (2.2×10(9) CFU/mL), group 4 received FOS (4 g/kg per day), and group 5 received Lactobacillus paracasei N1115 (2...
December 20, 2017: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/29324774/activated-carbon-n-acetylcysteine-microcapsule-protects-against-nonalcoholic-fatty-liver-disease-in-young-rats-via-activating-telomerase-and-inhibiting-apoptosis
#11
Tingting Shi, Xingxin Yang, Hongping Zhou, Jianjun Xi, Jingjing Sun, Yunling Ke, Jiankang Zhang, Yidan Shao, Xiaojie Jiang, Xuwang Pan, Shourong Liu, Rangxiao Zhuang
Non-alcoholic fatty liver disease (NAFLD) is becoming one of the world's most common chronic liver diseases in childhood, yet no therapy is available that has been approved by the food and drug administration (FDA). Previous studies have reported that telomere and telomerase are involved the development and progression of NAFLD. This study was designed to investigate the potential beneficial effects of activated carbon N-acetylcysteine (ACNAC) microcapsules on the development of NAFLD in young rats as well as the underlying mechanism(s) involved...
2018: PloS One
https://www.readbyqxmd.com/read/29322691/raspberry-supplementation-improves-insulin-signaling-and-promotes-brown-like-adipocyte-development-in-white-adipose-tissue-of-obese-mice
#12
Tong Xing, Yifei Kang, Xinglian Xu, Bo Wang, Min Du, Mei-Jun Zhu
SCOPE: Excessive lipid accumulation in white adipose tissue (WAT) leads to chronic inflammation and metabolic dysfunction. Raspberry (RB) contains high amount of polyphenolics and dietary fibers. The objective of the study is to evaluate effects of RB supplementation on WAT morphology, inflammation and insulin signaling in high fat diet (HFD)-induced obese mice, and further explore the underlying mechanisms. METHODS AND RESULTS: C57BL/6J mice were fed with a control diet or a HFD supplemented with 0 or 5% freeze dried RB for 12 weeks...
January 10, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29321950/manifestations-of-renal-impairment-in-fructose-induced-metabolic-syndrome
#13
Kameliya Bratoeva, George S Stoyanov, Albena Merdzhanova, Mariya Radanova
Introduction International studies show an increased incidence of chronic kidney disease (CKD) in patients with metabolic syndrome (MS). It is assumed that the major components of MS - obesity, insulin resistance, dyslipidemia, and hypertension - are linked to renal damage through the systemic release of several pro-inflammatory mediators, such as uric acid (UA), C-reactive protein (CRP), and generalized oxidative stress. The aim of the present study was to investigate the extent of kidney impairment and manifestations of dysfunction in rats with fructose-induced MS...
November 7, 2017: Curēus
https://www.readbyqxmd.com/read/29321388/suppression-of-abdominal-aortic-aneurysm-formation-in-mice-by-teneligliptin-a-dipeptidyl-peptidase-4-inhibitor
#14
Yusuke Takahara, Tomotake Tokunou, Toshihiro Ichiki
AIM: Dipeptidyl peptidase-4 (DPP-4) inhibitors lower blood glucose levels through inhibition of incretin degradation, which stimulates insulin secretion. Recent studies reported that DPP-4 inhibitors suppressed atherogenesis in apolipoprotein E-knockout (ApoEKO) mice. In this study, we investigated whether teneligliptin, a DPP-4 inhibitor, affects the development of abdominal aortic aneurysms (AAA) in ApoEKO mice. METHODS: ApoEKO mice were fed a high-fat diet (HFD) and infused with angiotensin (Ang) II by osmotic mini pumps for 4 weeks to induce AAA with (DPP-4i group) or without (control group) teneligliptin administered orally from 1 week before HFD and Ang II infusion to the end of the experiment...
January 10, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29320433/benefits-of-fish-oil-consumption-over-other-sources-of-lipids-on-metabolic-parameters-in-obese-rats
#15
Paula Novato Gondim, Priscila Vieira Rosa, Daniel Okamura, Viviam De Oliveira Silva, Eric Francelino Andrade, Daniel Arrais Biihrer, Luciano José Pereira
This study evaluated the effect of the consumption of different levels and sources of lipids on metabolic parameters of Wistar rats. Animals were fed with high-fat diet (HFD) containing 20% of lard for 12 weeks to cause metabolic obesity. Subsequently, the animals were divided into six groups and were fed diets with lipid concentrations of 5% or 20% of lard (LD), soybean oil (SO) or fish oil (FO), for 4 weeks. Data were submitted to analysis of variance (two-way) followed by Tukey post hoc test (p < 0.05)...
January 10, 2018: Nutrients
https://www.readbyqxmd.com/read/29319388/woohwangcheongsimwon-prevents-high-fat-diet-induced-memory-deficits-and-induces-sirt1-in-mice
#16
Hyunwoo Park, Mia Kim, Im-Joon Shin, Jonghee Park, Soo Yong Bang, Chunsik Yi, Myoung-Ae Kim, Jae-Hwan Lew, Joo Won Suh, Sungho Maeng
Woohwangcheongsimwon (WHC) is a mixture of herbal medicines that is widely prescribed in Korean traditional medicine. SIRT1 is known for its regulatory roles in energy metabolism, oxidative stress, and circadian rhythms. This study was designed to determine whether WHC can increase and mimic the biological reactions of SIRT1 activation. Ten-month-old male mice were divided into four groups: nontreated normal diet (ND), nontreated high-fat diet (HFD), WHC-treated ND, and WHC-treated HFD. Body weight and cognitive functions were evaluated after treatment...
January 10, 2018: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29319168/hepatic-mir-125b-inhibits-insulin-signaling-pathway-by-targeting-pik3cd
#17
Xiliang Du, Xiaobing Li, Liang Chen, Min Zhan, Lin Lei, Wenwen Gao, Zhen Shi, Yuhao Dong, Zhe Wang, Xinwei Li, Guowen Liu
Insulin resistance is often characterized as the most critical factor contributing to the development of (T2D) type 2 diabetes. MicroRNAs (miRNAs) are endogenous non-coding short single-stranded RNAs that function as negative regulators in many physiological and pathological processes. The objective of this study was to evaluate the roles of miR-125b in the regulation of insulin sensitivity in hepatocytes. We found that hepatic miR-125b levels were significantly increased in the patients with type 2 diabetes, high fat diet (HFD) mice, ob/ob and db/db mice...
January 10, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29316965/decreased-microglial-activation-through-gut-brain-axis-by-prebiotics-probiotics-or-synbiotics-effectively-restored-cognitive-function-in-obese-insulin-resistant-rats
#18
Titikorn Chunchai, Wannipa Thunapong, Sakawdaurn Yasom, Keerati Wanchai, Sathima Eaimworawuthikul, Gabrielle Metzler, Anusorn Lungkaphin, Anchalee Pongchaidecha, Sasithorn Sirilun, Chaiyavat Chaiyasut, Wasana Pratchayasakul, Parameth Thiennimitr, Nipon Chattipakorn, Siriporn C Chattipakorn
BACKGROUND: Chronic high-fat diet (HFD) consumption caused not only obese-insulin resistance, but also cognitive decline and microglial hyperactivity. Modified gut microbiota by prebiotics and probiotics improved obese-insulin resistance. However, the effects of prebiotics, probiotics, and synbiotics on cognition and microglial activity in an obese-insulin resistant condition have not yet been investigated. We aimed to evaluate the effect of prebiotic (Xyloolidosaccharide), probiotic (Lactobacillus paracasei HII01), or synbiotics in male obese-insulin resistant rats induced by a HFD...
January 9, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29316242/sustained-high-fat-diet-modulates-inflammation-insulin-signalling-and-cognition-in-mice-and-a-modified-xenin-peptide-ameliorates-neuropathology-in-a-chronic-high-fat-model
#19
Paul Denver, Victor A Gault, Paula L McClean
AIMS: Metabolic disease increases risk of Alzheimer's disease and cognitive dysfunction. Chronic high fat diet (HFD) feeding leads to cognitive impairment and neuroinflammation. This study demarcated pathological events in brain as a result of short-term to chronic HFD feeding. Efficacy of Xenin-25[Lys(13)PAL] was assessed in chronic HFD-fed mice. METHODS: C57BL/6 mice were fed HFD or normal diet for 18 days, 34 days, 10 and 21 weeks. Cognition was assessed using novel object recognition and Morris water maze...
January 5, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29315766/disruption-of-adenosine-2a-receptor-exacerbates-nafld-through-increasing-inflammatory-responses-and-srebp1c-activity
#20
Yuli Cai, Honggui Li, Mengyang Liu, Ya Pei, Juan Zheng, Jing Zhou, Xianjun Luo, Wenya Huang, Linqiang Ma, Qiuhua Yang, Shaodong Guo, Xiaoqiu Xiao, Qifu Li, Tianshu Zeng, Fanyin Meng, Heather Francis, Shannon Glaser, Lulu Chen, Yuqing Huo, Gianfranco Alpini, Chaodong Wu
Adenosine 2A receptor (A2A R) exerts protective roles in endotoxin- and/or ischemia-induced tissue damages. However, the role for A2A R in non-alcoholic fatty liver disease (NAFLD) remains largely unknown. We sought to examine the effects of global and/or myeloid cell-specific A2A R disruption on the aspects of obesity-associated NAFLD and to elucidate the underlying mechanisms. Global and/or myeloid cell-specific A2A R-disrupted mice, as well as control mice were fed a high-fat diet (HFD) to induce NAFLD. Also, bone marrow-derived macrophages and primary mouse hepatocytes were examined for inflammatory and metabolic responses...
January 9, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
keyword
keyword
75560
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"