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https://www.readbyqxmd.com/read/28926107/fenofibrate-reverses-changes-induced-by-high-fat-diet-on-metabolism-in-mice-muscle-and-visceral-adipocytes
#1
Flávia de Toledo Frias, Karina Cunha E Rocha, Mariana de Mendonça, Gilson Massahiro Murata, Hygor Nunes Araujo, Luís Gustavo Oliveira de Sousa, Érica de Souza, Sandro Massao Hirabara, Nayara de Carvalho Leite, Everardo Magalhães Carneiro, Rui Curi, Leonardo Reis Silveira, Alice Cristina Rodrigues
The effect of fenofibrate on the metabolism of skeletal muscle and visceral white adipose tissue of diet-induced obese (DIO) mice was investigated. C57BL/6J male mice were fed either a control or high-fat diet for eight weeks. Fenofibrate (50 mg/Kg b.w., daily) was administered by oral gavage during the last two weeks of the experimental period. Insulin-stimulated glucose metabolism in soleus muscles, glucose tolerance test, insulin tolerance test, indirect calorimetry, lipolysis of visceral white adipose tissue, expression of miR-103-3p in adipose tissue and miR-1a, miR-133a/b, miR-206, let7b-5p, miR-23b-3p, miR-29-3p, miR-143-3p in soleus muscle, genes related to glucose and fatty acid metabolism in adipose tissue and soleus muscle, and proteins (phospho-AMPKα2, Pgc1α, Cpt1b), intramuscular lipid staining, and activities of fatty acid oxidation enzymes in skeletal muscle were investigated...
September 19, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28925407/foxc2-coordinates-inflammation-and-browning-of-white-adipose-by-leptin-stat3-prdm16-signal-in-mice
#2
L Gan, Z Liu, F Feng, T Wu, D Luo, C Hu, C Sun
AIMS: The objective of this study is to characterize the relationship between forkhead box C2 protein (Foxc2) and leptin under adipose inflammatory response. METHODS: Lipopolysaccharide (LPS)-induced inflammatory model was conducted. Data from wild-type and ob/ob mice were used to compare the alternative role of leptin on Foxc2-mediated inflammation and browning. Transcriptional regulation and protein-protein interaction were analyzed by bioinformatics and proved by chromatin immunoprecipitation and co-immunoprecipitation experiment...
August 23, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28921898/maternal-chronic-folate-supplementation-ameliorates-behavior-disorders-induced-by-prenatal-high-fat-diet-through-methylation-alteration-of-bdnf-and-grin2b-in-offspring-hippocampus
#3
Zhonghai Yan, Fei Jiao, Xiaoshuang Yan, Hailong Ou
SCOPE: Maternal consumption of a high-fat diet (HFD) during pregnancy increases the risk of behavioral problems. Folate plays an important role in neuroplasticity and the preservation of neuronal integrity. This study aimed at determining the influence of diets supplemented with folate on offspring behavior, and the mechanisms involved. METHODS AND RESULTS: Female mice were fed a control diet, a high-fat diet, control diet supplemented with folate, or a high-fat diet supplemented with folate for 5 wks before mating...
September 17, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28921743/exercise-training-dose-differentially-alters-muscle-and-heart-capillary-density-and-metabolic-functions-in-an-obese-rat-with-metabolic-syndrome
#4
Marcus Vinicius Machado, Aline Bomfim Vieira, Fabiana Gomes da Conceição, Alessandro Rodrigues Nascimento, Antonio Claudio Lucas da Nóbrega, Eduardo Tibirica
We evaluated the effect of frequency, duration and intensity of exercise training on metabolic parameters and structural capillary density in obese rats with metabolic syndrome (MS). Wistar-Kyoto rats were fed a either standard commercial diet (CON) or high-fat diet (HFD). Animals that received the HFD were randomly separated into either a sedentary (SED) group or 8 different exercise groups that varied by the frequency, duration and intensity of training. After 12 weeks of aerobic exercise training, body composition, aerobic capacity, hemodynamic variables, metabolic parameters and capillary density in the heart and skeletal muscle were evaluated...
September 17, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28921462/bifidobacterium-pseudocatenulatum-cect-7765-ameliorates-neuroendocrine-alterations-associated-with-an-exaggerated-stress-response-and-anhedonia-in-obese-mice
#5
Ana Agusti, A Moya-Pérez, I Campillo, S Montserrat-de la Paz, V Cerrudo, A Perez-Villalba, Yolanda Sanz
Obesity, besides being a problem of metabolic dysfunction, constitutes a risk factor for psychological disorders. Experimental models of diet-induced obesity have revealed that obese animals are prone to anxious and depressive-like behaviors. The present study aimed to evaluate whether Bifidobacterium pseudocatenulatum CECT 7765 could reverse the neurobehavioral consequences of obesity in a high-fat diet (HFD) fed mouse model via regulation of the gut-brain axis. Adult male wild-type C57BL-6 mice were fed a standard diet or HFD, supplemented with either placebo or the bifidobacterial strain for 13 weeks...
September 18, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28920396/-inhibition-of-chitin-oligosaccharide-on-dyslipidemia-and-the-potential-molecular-mechanism-exploration
#6
Fanqi Yi, Junping Zheng, Qiongyu Li, Siming Jiao, Yuguang Du, Yun Ye, Hongtao Liu
The inhibitory effect of NACOS on dyslipidemia and potential molecular mechanisms by in vitro and in vivo experiments were investigated. For in vitro study, four experimental groups were designed by using HepG2 cells, including the control group, palmitic acid (PA) treatment alone group, NACOS treatment alone group and NACOS + PA treatment group. For in vivo study, male C57BL/6 mice were divided into four groups (n=5) at random including the normal control group (NCD), high fat diet (HFD) group, NACOS treatment alone group, NACOS+HFD group, which were treated for 20 weeks...
April 25, 2017: Sheng Wu Gong Cheng Xue Bao, Chinese Journal of Biotechnology
https://www.readbyqxmd.com/read/28919478/atorvastatin-reduces-lipid-accumulation-in-the-liver-by-activating-protein-kinase-a-mediated-phosphorylation-of-perilipin-5
#7
Xing Gao, Yang Nan, Yuanlin Zhao, Yuan Yuan, Bincheng Ren, Chao Sun, Kaiyu Cao, Ming Yu, Xuyang Feng, Jing Ye
Statins have been proven to be effective in treating non-alcoholic fatty liver disease (NAFLD). Recently, it was reported that statins decreased the hepatic expression of perilipin 5 (Plin5), a lipid droplet (LD)-associated protein, which plays critical roles in regulating lipid accumulation and lipolysis in liver. However, the function and regulation mechanism of Plin5 have not yet been well-established in NAFLD treatment with statins. In this study, we observed that atorvastatin moderately reduced the expression of Plin5 in livers without changing the protein level of Plin5 in the hepatic LD fraction of mice fed with high-fat diet (HFD)...
September 12, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28919001/pharmacological-inhibition-of-aldh1a-enzymes-suppresses-weight-gain-in-a-mouse-model-of-diet-induced-obesity
#8
Michael Haenisch, Piper M Treuting, Thea Brabb, Alex S Goldstein, Kathryn Berkseth, John K Amory, Jisun Paik
BACKGROUND: Retinoic acid (RA) is known to play a role in weight regulation. Because mice without ALDH1A1, a major RA synthesizing enzyme, are resistant to diet-induced obesity, we tested a hypothesis that pharmacological inhibition of RA synthesis can suppress weight gain in a murine model of diet-induced obesity. METHODS: C57BL/6J male mice were fed a high fat diet (HFD) for 8 weeks to induce obesity and then randomized to a HFD with or without WIN 18,446, an RA synthesis inhibitor, for an additional 9 weeks...
September 11, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28914596/obesity-and-periodontitis-an-experimental-study-to-evaluate-the-periodontal-and-systemic-effects-of-the-co-morbidity
#9
Leire Virto, Pilar Cano, Vanesa Jiménez-Ortega, Pilar Fernández-Mateos, Jerián González, Ana Isabel Esquifino, Mariano Sanz
BACKGROUND: Obesity and overweight have been associated with periodontitis. This study aims to evaluate the periodontal and systemic effects of this association in a validated experimental model. METHODS: 28 male Wistar rats were randomly divided in four groups: control group (Con) (fed with standard diet); high-fat diet group (HFD) (fed with a diet containing 35.2% fat); control group with induced periodontitis (Con-Perio) and HFD group with induced periodontitis (HFD-Perio)...
September 15, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28914129/maternal-high-fat-diet-programs-cerebrovascular-remodeling-in-adult-rat-offspring
#10
ChengCheng Lin, XiaoYun Wu, YuLei Zhou, Bei Shao, XiaoTing Niu, WanLi Zhang, YuanShao Lin
Maternal environmental factors such as diet have consequences on later health of the offspring. We found that maternal high-fat diet (HFD) exposure renders adult offspring brain more susceptible to ischemic injury. The present study was further to investigate whether HFD consumption during rat pregnancy and lactation influences the cerebral vasculature in adult male offspring. Besides the endothelial damage observed in the transmission electron microscopy, the MCAs of offspring from fat-fed dams fed with control diet (HFD/C) also displayed increased wall thickness and media/lumen ratio, suggesting that cerebrovascular hypertrophy or hyperplasia occurs...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28911169/obesity-induced-infertility-in-male-mice-is-associated-with-disruption-of-crisp4-expression-and-sperm-fertilization-capacity
#11
Beatriz C Borges, David Garcia-Galiano, Sanseray da Silveira Cruz-Machado, Xingfa Han, Galina B Gavrilina, Thomas L Saunders, Richard J Auchus, Saher S Hammoud, Gary D Smith, Carol F Elias
Approximately 15% of human couples of reproductive age have impaired fertility, and the male component accounts for about half of these cases. The etiology is usually unknown, but high correlation with the increase in obesity rates is documented. In this study, we show that diet-induced and genetically obese mice display copulatory behavior comparable to controls, but the number of females impregnated by obese males is remarkably low. Screening for changes in gene expression in the male reproductive tract showed decreased Crisp4 expression in testis and epididymis of obese mice...
September 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28905319/pi3k-inhibition-protects-mice-from-nafld-by-down-regulating-cmklr1-and-nlrp3-in-kupffer-cells
#12
Wenfeng Zhang, Yan Liu, Mingbing Wu, Xiwen Zhu, Tao Wang, Kun He, Peizhi Li, Xiaoling Wu
Inflammation induced by high-fat diet (HFD) is of critical importance in the development of hepatic steatosis. The role of chemerin in the progress of nonalcoholic fatty liver disease (NAFLD) remains controversial. Here, we have evaluated the effects and mechanism of chemerin on insulin sensitivity and inflammation. An inhibitor (wortmannin) and agonist (insulin-like growth factor 1 (IGF-1) of phosphatidyl inositol 3-kinase (PI3K) were applied to Kupffer cells (KCs) after treatment with a concentration gradient of chemerin in vitro...
September 13, 2017: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28904866/imm-h007-a-new-therapeutic-candidate-for-nonalcoholic-fatty-liver-disease-improves-hepatic-steatosis-in-hamsters-fed-a-high-fat-diet
#13
Huijie Shi, Qingchun Wang, Liu Yang, Shouxia Xie, Haibo Zhu
Nonalcoholic fatty liver disease (NAFLD), the most common chronic liver disease in humans, is characterized by the accumulation of triacylglycerols (TGs) in hepatocytes. We tested whether 2',3',5'-tri-acetyl-N6-(3-hydroxylaniline) adenosine (IMM-H007) can eliminate hepatic steatosis in hamsters fed a high-fat diet (HFD), as a model of NAFLD. Compared with HFD-only controls, IMM-H007 treatment significantly lowered serum levels of TG, total cholesterol, and free fatty acids (FFAs) in hamsters fed the HFD, with a prominent decrease in levels of serum transaminases and fasting insulin, without affecting fasting glucose levels...
September 2017: FEBS Open Bio
https://www.readbyqxmd.com/read/28903761/protective-effects-of-grape-seed-and-skin-extract-against-high-fat-diet-induced-lipotoxicity-in-rat-lung
#14
Mohamed El Ayed, Safwen Kadri, Selima Smine, Salem Elkahoui, Ferid Limam, Ezzedine Aouani
BACKGROUND: Obesity is a public health problem characterized by increased fat accumulation in different tissues. Obesity is directly linked to breathing problems and medical complications with lung, including obstructive sleep apnea syndrome, obesity hypoventilation syndrome, chronic obstructive pulmonary disease, asthma….In the present work, we aimed to investigate the effect of high fat diet (HFD) on lung lipotoxicity, oxidative stress, fatty acid composition and proportions in lung and implication in asthma development...
September 13, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28903486/nonalcoholic-fatty-liver-disease-is-a-susceptibility-factor-for-perchloroethylene-induced-liver-effects-in-mice
#15
Joseph A Cichocki, Shinji Furuya, Yu-Syuan Luo, Yasuhiro Iwata, Kranti Konganti, Weihsueh A Chiu, David W Threadgill, Igor P Pogribny, Ivan Rusyn
Nonalcoholic fatty liver disease (NAFLD) is the most prevalent pathological liver condition in developed countries. NAFLD results in severe alterations in liver function, including xenobiotic metabolism. Perchloroethylene (PERC) is a ubiquitous environmental pollutant, a known hepatotoxicant in rodents, and a probable human carcinogen. It is known that PERC disposition and metabolism are affected by NAFLD in mice; here, we examined how NAFLD changes PERC-associated liver effects. Male C57Bl6/J mice were fed a low-fat diet (LFD), high-fat diet (HFD), or methionine/folate/choline-deficient diet (MCD) to model a healthy liver, or mild and severe forms of NAFLD, respectively...
September 1, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28901330/a-history-of-obesity-leaves-an-inflammatory-fingerprint-in-liver-and-adipose-tissue
#16
I P Fischer, M Irmler, C W Meyer, S J Sachs, F Neff, M H de Angelis, J Beckers, M H Tschöp, S M Hofmann, S Ussar
BACKGROUND/OBJECTIVE: Dieting is a popular yet often ineffective way to lower body weight, as the majority of people regain most of their pre-dieting weights in a relatively short time. The underlying molecular mechanisms driving weight regain and the increased risk for metabolic disease are still incompletely understood. Here we investigate the molecular alterations inherited from a history of obesity. METHODS: In our model, male HFD fed obese C57BL/6J mice, were switched to a low caloric chow diet, resulting in a decline of body weight to that of lean mice...
September 13, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28900676/free-fatty-acid-receptor-4-mediates-the-beneficial-effects-of-n-3-fatty-acids-on-body-composition-in-mice
#17
Han Jin Cho, Seong Hee Ahn, Young-Sun Lee, Seung Hun Lee, Dong-Soon Im, Inki Kim, Jung-Min Koh, Sungsub Kim, Beom-Jun Kim
As populations continue to age worldwide, sarcopenic obesity has heightened interest due to its medical importance. Although much evidence now indicates that n-3 fatty acids (FAs) may have beneficial effects on body composition including fat and muscle, their exact mechanisms have not yet been elucidated. Because free FA receptor 4 (FFA4) has been reported to be a receptor for n-3 FAs, we hypothesized that the protective role of n-3 FAs on body composition could be mediated by FFA4. To test this possibility, we generated mice overexpressing n-3 FAs but lacking FFA4 by crossing fat-1 transgenic (fat-1 (Tg+)) and FFA4 knockout (Ffar4 (-/-)) mice...
September 12, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28900399/acacetin-from-traditionally-used-saussurea-involucrata-kar-et-kir-suppressed-adipogenesis-in-3t3-l1-adipocytes-and-attenuated-lipid-accumulation-in-obese-mice
#18
Chian-Jiun Liou, Shu-Ju Wu, Li-Chen Chen, Kuo-Wei Yeh, Chih-Ying Chen, Wen-Chung Huang
Acacetin, a flavone that can be isolated from the Saussurea involucrata plant, has anti-tumor and anti-inflammatory properties that ameliorate airway hyperresponsiveness in asthmatic mice. This study investigated whether acacetin has anti-adipogenic effects in 3T3-L1 adipocytes and whether it regulates the inflammatory response in adipocytes and macrophages. It also investigated whether acacetin ameliorates lipid accumulation in high-fat diet- (HFD) induced obese mice. Differentiated 3T3-L1 cells were treated with acacetin...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28900305/berberine-ameliorates-fatty-acid-induced-oxidative-stress-in-human-hepatoma-cells
#19
Yixuan Sun, Xinlu Yuan, Feifei Zhang, Yamei Han, Xinxia Chang, Xi Xu, Yu Li, Xin Gao
Oxidative stress is thought to be critical for the pathogenesis of hepatic steatosis and its progress to non-alcoholic steatohepatitis. Berberine (BBR) can improve hepatic steatosis. In this study, we investigated the role of BBR in ameliorating oxidative stress. Lipid accumulation was measured in the livers of C57BL/6 mice fed a high fat diet (HFD) or a normal diet for 8 weeks, then either received BBR or vehicle for the study duration. Nrf2 distribution was detected in male Sprague-Dawley rats' livers in vivo and in Huh7 cells in vitro...
September 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28899784/mir-181b-regulates-steatosis-in-nonalcoholic-fatty-liver-disease-via-targeting-sirt1
#20
Yunxia Wang, Kongxi Zhu, Weihua Yu, Hongjuan Wang, Lan Liu, Qiong Wu, Shuai Li, Jianqiang Guo
Non-alcoholic fatty liver diseases (NAFLD) is one of the leading cause of chronic liver diseases in the world. However, the pathogenesis of NAFLD is still unclear. Emerging studies have demonstrated that microRNAs (miRs) are profoundly involved in NAFLD and related metabolic diseases. Here, we investigated the mechanisms by which miR-181b influences NAFLD via direct targeting SIRT1. The expression of miR181b was up-regulated while SIRT1 was down-regulated in both human NAFLD patients and high fat diet (HFD) induced NAFDL mice model...
September 9, 2017: Biochemical and Biophysical Research Communications
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