keyword
MENU ▼
Read by QxMD icon Read
search

HFD

keyword
https://www.readbyqxmd.com/read/28433470/daily-supplementation-of-dietary-protein-improves-the-metabolic-effects-of-glp-1-based-pharmacotherapy-in-lean-and-obese-rats
#1
Elizabeth G Mietlicki-Baase, Kieran Koch-Laskowski, Lauren E McGrath, Joanna Krawczyk, Tram Pham, Rinzin Lhamo, David J Reiner, Matthew R Hayes
Glucagon-like peptide-1 (GLP-1) is an incretin hormone released from intestinal L-cells in response to food entering into the gastrointestinal tract. GLP-1-based pharmaceuticals improve blood glucose regulation and reduce feeding. Specific macronutrients, when ingested, may trigger GLP-1 secretion and enhance the effects of systemic sitagliptin, a pharmacological inhibitor of DPP-IV (an enzyme that rapidly degrades GLP-1). In particular, macronutrient constituents found in dairy foods may act as potent secretagogues for GLP-1, and acute preclinical trials show that ingestion of dairy protein may represent a promising adjunct behavioral therapy in combination with sitagliptin...
April 19, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28430962/ulk1-prevents-cardiac-dysfunction-in-obesity-through-autophagy-meditated-regulation-of-lipid-metabolism
#2
Minae An, Dong-Ryeol Ryu, Jang Won Park, Ji Ha Choi, Eun-Mi Park, Kyung Eun Lee, Minna Woo, Minsuk Kim
Aims: Autophagy is essential to maintain tissue homeostasis, particularly in long-lived cells such as cardiomyocytes. Whereas many studies support the importance of autophagy in the mechanisms underlying obesity-related cardiac dysfunction, the role of autophagy in cardiac lipid metabolism remains unclear. In the heart, lipotoxicity is exacerbated by cardiac lipoprotein lipase (LPL), which mediates accumulation of fatty acids to the heart through intravascular triglyceride (TG) hydrolysis...
April 17, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28429344/up-regulation-of-microrna-367-promotes-liver-steatosis-through-repressing-tbl1-in-obese-mice
#3
D-D Li, Y Liu, L Xue, D-Y Su, W-Y Pang
OBJECTIVE: Increasing evidence has demonstrated that microRNAs (miRNAs) play a critical role in the progression of metabolic disorders, including obesity-induced non-alcoholic fatty liver disease (NAFLD). In the present study, the expression and function of miR-367 were investigated. MATERIALS AND METHODS: C57BL/6 male mice aged 8 weeks were fed with a normal diet (ND) or high-fat-diet (HFD). The expression levels of miR-367 were analyzed in livers from two groups of mice by quantitative real-time PCR...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28429150/short-term-high-fat-diet-induces-obesity-enhancing-changes-in-mouse-gut-microbiota-that-are-partially-reversed-by-cessation-of-the-high-fat-diet
#4
Yue Shang, Ehsan Khafipour, Hooman Derakhshani, Lindsei K Sarna, Connie W Woo, Yaw L Siow, Karmin O
The gut microbiota is proposed as a "metabolic organ" involved in energy utilization and is associated with obesity. Dietary intervention is one of the approaches for obesity management. Changes in dietary components have significant impacts on host metabolism and gut microbiota. In the present study, we examined the influence of dietary fat intervention on the modification of gut mucosa-associated microbiota profile along with body weight and metabolic parameter changes. Male C57BL/6J mice (6-week old) were fed a low fat diet (10% kcal fat) as a control or a high fat diet (HFD 60% kcal fat) for 7 weeks...
April 20, 2017: Lipids
https://www.readbyqxmd.com/read/28428430/collagen-beta-1-o-galactosyltransferase-1-glt25d1-is-required-for-the-secretion-of-high-molecular-weight-adiponectin-and-affects-lipid-accumulation
#5
Julie A Webster, Zhe Yang, Yu-Hee Kim, Dorothy Loo, Rasha M Mosa, Hongzhuo Li, Chen Chen
Secretion of high molecular weight (HMW) adiponectin is dependent on post-translational modification (PTM) of conserved lysines in the collagenous domain. This work aims to characterize the enzymes responsible for the PTM of conserved lysines which leads to HMW adiponectin secretion, and to define its significance in relation to obesity.  Collagen beta (1- O ) galactosyltransferase 1 (GLT25D1) was knocked down in HEK cells modified for the stable expression of adiponectin (Adipo-HEK cells) as well as in Simpson Golabi-Behmel-Syndrome (SGBS) adipocytes...
April 20, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28427239/foxo3a-dependent-bim-transcription-protects-mice-from-a-high-fat-diet-via-inhibition-of-activation-of-the-nlrp3-inflammasome-by-facilitating-autophagy-flux-in-kupffer-cells
#6
Liu Yan, Zhang Wenfeng, Wu Xiaoling, Gong Jianping
BACKGROUND: The role of Foxo3a in the regulation of autophagy flux and activation of the NLRP3 inflammasome in KCs suffering from HFD conditions is unknown. RESULTS: Up-regulation of Foxo3a restored autophagy flux and dampened the activation of the NLRP3 inflammasome in KCs stimulated with PA and LPS. In contrast, down-regulation of Foxo3a increased blockage of autophagy flux and promoted NLRP3 inflammasome activation. Additionally, mRNA levels of Bim were significantly changed with the alteration of Foxo3a in KCs under PA and LPS stimulation among foxo3a targeted genes...
March 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28426873/high-fat-diet-induced-leptin-and-wnt-expression-rna-sequencing-and-pathway-analysis-of-mouse-colonic-tissue-and-tumors
#7
Harrison M Penrose, Sandra Heller, Chloe Cable, Hani Nakhoul, Melody Baddoo, Erik Flemington, Susan E Crawford, Suzana D Savkovic
Obesity, an immense epidemic affecting approximately half a billion adults, has doubled in prevalence in the last several decades. Epidemiological data support that obesity, due to intake of a high-fat, western diet, increases the risk of colon cancer; however, the mechanisms underlying this risk remain unclear. Here, utilizing next generation RNA sequencing, we aimed to determine the high-fat diet (HFD) mediated expression profile in mouse colon and the azoxymethane/dextran sulfate sodium model of colon cancer...
March 1, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28426713/metallothioneins-regulate-the-adipogenic-differentiation-of-3t3-l1-cells-via-the-insulin-signaling-pathway
#8
Yoshito Kadota, Yuriko Toriuchi, Yuka Aki, Yuto Mizuno, Takashige Kawakami, Tomoko Nakaya, Masao Sato, Shinya Suzuki
Knockout of metallothionein (MT) genes contributes to a heavier body weight in early life and the potential to become obese through the intake of a high fat diet (HFD) in mice. It has thus been suggested that MT genes regulate the formation of adipose tissue, which would become the base for later HFD-induced obesity. We evaluated the fat pads of mice during the lactation stage. The fat mass and adipocyte size of MT1 and MT2 knockout mice were greater than those of wild type mice. Next, we assayed the ability of small interfering RNA (siRNA) to silence MT genes in the 3T3-L1 cell line...
2017: PloS One
https://www.readbyqxmd.com/read/28425943/beneficial-effect-of-voluntary-exercise-on-experimental-colitis-in-mice-fed-a-high-fat-diet-the-role-of-irisin-adiponectin-and-proinflammatory-biomarkers
#9
Agnieszka Irena Mazur-Bialy, Jan Bilski, Dagmara Wojcik, Bartosz Brzozowski, Marcin Surmiak, Magdalena Hubalewska-Mazgaj, Anna Chmura, Marcin Magierowski, Katarzyna Magierowska, Tomasz Mach, Tomasz Brzozowski
Inflammatory bowel diseases (IBDs) are a heterogeneous group of disorders exhibited by two major phenotypic forms: Crohn's disease and ulcerative colitis. Although the aetiology of IBD is unknown, several factors coming from the adipose tissue and skeletal muscles, such as cytokines, adipokines and myokines, were suggested in the pathogenesis of ulcerative colitis; however, it has not been extensively studied whether voluntary exercise can ameliorate that disorder. We explored the effect of moderate exercise (i...
April 20, 2017: Nutrients
https://www.readbyqxmd.com/read/28422772/can-ultrasound-imaging-predict-the-success-of-an-experimental-steatofibrosis-model
#10
Rustu Turkay, Abdurrahman Fatih Aydin, Ilknur Bingul, Canan Kucukgergin, Isin Dogan-Ekici, Elif Hocaoglu, Ercan Inci, Baris Bakir, Mujdat Uysal
Our goal was to evaluate the role of ultrasound (US) imaging in an experimental 2-hit steatofibrosis rat model. Nineteen female Sprague-Dawley rats were divided into 2 groups: control group (n = 6) and high-fat diet carbontetrachloride (HFD-CCl4) group (n = 13) that was fed with HFD for 14 weeks. Ultrasound was performed to evaluate liver steatosis. The HFD-CCl4 group rats were divided further into 2 subgroups: HFD rats with liver steatosis [US (+) group; n = 6] and without steatosis [US (-) group; n = 7]. All rats in the subgroups were administered with CCl4...
April 19, 2017: Ultrasound Quarterly
https://www.readbyqxmd.com/read/28422186/high-fat-diet-induces-systemic-b-cell-repertoire-changes-associated-with-insulin-resistance
#11
T D Pham, M H Y Chng, K M Roskin, K J L Jackson, K D Nguyen, J Glanville, J-Y Lee, E G Engleman, S D Boyd
The development of obesity-associated insulin resistance is associated with B-lymphocyte accumulation in visceral adipose tissue (VAT) and is prevented by B-cell ablation. To characterize potentially pathogenic B-cell repertoires in this disorder, we performed high-throughput immunoglobulin (Ig) sequencing from multiple tissues of mice fed high-fat diet (HFD) and regular diet (RD). HFD significantly changed the biochemical properties of Ig heavy-chain complementarity-determining region-3 (CDRH3) sequences, selecting for IgA antibodies with shorter and more hydrophobic CDRH3 in multiple tissues...
April 19, 2017: Mucosal Immunology
https://www.readbyqxmd.com/read/28420713/acute-versus-chronic-exposure-to-high-fat-diet-leads-to-distinct-regulation-of-pka
#12
Edra London, Maria Nesterova, Constantine A Stratakis
The cAMP-dependent protein kinase (PKA) is an essential regulator of lipid and glucose metabolism that plays a critical role in energy homeostasis. The impact of diet on PKA signaling has not been defined, although perturbations in individual PKA subunits are associated with changes in adiposity, physical activity, and energy intake in mice and humans. We hypothesized that a high fat diet (HFD) would elicit peripheral and central alterations in the PKA system that would differ depending on length of exposure to HFD; these differences could protect against or promote diet-induced obesity (DIO)...
April 18, 2017: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/28420164/the-angiogenesis-inhibitor-als-l1023-from-lemon-balm-leaves-attenuates-high-fat-diet-induced-nonalcoholic-fatty-liver-disease-through-regulating-the-visceral-adipose-tissue-function
#13
Jeongjun Kim, Haerim Lee, Jonghoon Lim, Jaeho Oh, Soon Shik Shin, Michung Yoon
Similar to neoplastic tissues, growth and development of adipose tissue are thought to be angiogenesis-dependent. Since visceral adipose tissue (VAT) is associated with development and progression of nonalcoholic fatty liver disease (NAFLD), we hypothesized that angiogenesis inhibition would attenuate obesity-induced NAFLD. We fed C57BL/6J mice a low-fat diet (LFD, chow 10% kcal fat), a high-fat diet (HFD, 45% kcal fat) or HFD supplemented with the lemon-balm extract ALS-L1023 (HFD-ALS) for 15 weeks. ALS-L1023 reduced endothelial cell-tube formation in vitro...
April 17, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28420089/suppression-of-ghs-r-in-agrp-neurons-mitigates-diet-induced-obesity-by-activating-thermogenesis
#14
Chia-Shan Wu, Odelia Y N Bongmba, Jing Yue, Jong Han Lee, Ligen Lin, Kenji Saito, Geetali Pradhan, De-Pei Li, Hui-Lin Pan, Allison Xu, Shaodong Guo, Yong Xu, Yuxiang Sun
Ghrelin, an orexigenic hormone released primarily from the gut, signals the hypothalamus to stimulate growth hormone release, enhance appetite and promote weight gain. The ghrelin receptor, aka Growth Hormone Secretagogue Receptor (GHS-R), is highly expressed in the brain, with highest expression in Agouti-Related Peptide (AgRP) neurons of the hypothalamus. We recently reported that neuron-specific deletion of GHS-R completely prevents diet-induced obesity (DIO) in mice by activating non-shivering thermogenesis...
April 14, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28420087/skeletal-muscle-nucleo-mitochondrial-crosstalk-in-obesity-and-type-2-diabetes
#15
REVIEW
Prasad P Devarshi, Sean M McNabney, Tara M Henagan
Skeletal muscle mitochondrial dysfunction, evidenced by incomplete beta oxidation and accumulation of fatty acid intermediates in the form of long and medium chain acylcarnitines, may contribute to ectopic lipid deposition and insulin resistance during high fat diet (HFD)-induced obesity. The present review discusses the roles of anterograde and retrograde communication in nucleo-mitochondrial crosstalk that determines skeletal muscle mitochondrial adaptations, specifically alterations in mitochondrial number and function in relation to obesity and insulin resistance...
April 14, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28420006/increased-visfatin-expression-is-associated-with-nuclear-factor-kappa-%C3%AE-in-obese-ovalbumin-sensitized-male-wistar-rats-trachea
#16
Mohammad Reza Aslani, Rana Keyhanmanesh, Mohammad Reza Alipour
OBJECTIVE: To investigate the effects of diet-induced obesity on the expression of nuclear factor-kappa β and visfatin messenger RNA in male Wistar rats' tracheae after sensitization with ovalbumin (OVA). MATERIALS AND METHODS: Twenty (20) male Wistar rats were divided into four groups (n=5 for each group), that included a control fed normal diet (ND), and fed normal diet OVA-sensitized (S+ND), high-fat diet (HFD) only, (diet induced obesity) and high-fat diet OVA-sensitized (S+HFD)...
April 16, 2017: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/28419519/deletion-of-a-distal-rankl-gene-enhancer-delays-progression-of-atherosclerotic-plaque-calcification-in-hypercholesterolemic-mice
#17
Sohel Shamsuzzaman, Melda Onal, Hillary C St John, J Wesley Pike
Receptor activator of NF-κB ligand (RANKL) is a TNFα-like cytokine which mediates diverse physiological functions including bone remodeling and immune regulation. RANKL has been identified in atherosclerotic lesions; however, its role in atherosclerotic plaque development remains elusive. An enhancer located 75kb upstream of the murine RANKL gene's transcription start site designated D5 is important for its calciotropic hormone- and cytokine-mediated expression. Here, we determined the impact of RANKL levels in atherosclerotic plaque development in the D5 enhancer-null (D5(-/-) ) mice in an atherogenic Apoe(-/-) background fed a high-fat diet (HFD)...
April 17, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28419227/neural-programmatic-role-of-leptin-tnf%C3%AE-melanocortin-and-glutamate-in-blood-pressure-regulation-versus-obesity-related-hypertension-in-male-c57bl-6-mice
#18
Bin Yu, Dongsheng Cai
Continuous nutritional surplus sets the stage for hypertension development. While moderate dietary obesity in mice is normotensive, the homeostatic balance is disrupted concurrent with an increased risk of hypertension, but it remains unclear how the obesity-associated pre-hypertensive state is converted into overt hypertension. Here, using mice with high-fat-diet (HFD) feeding-induced moderate obesity vs. control-diet (CD) feeding lean mice, we comparatively studied the effects of central leptin and TNFα as well as the involvement of the neuropeptide melanocortin pathway versus the neurotransmitter glutamate pathway...
April 13, 2017: Endocrinology
https://www.readbyqxmd.com/read/28415686/chikusetsu-saponin-iva-ameliorates-high-fat-diet-induced-inflammation-in-adipose-tissue-of-mice-through-inhibition-of-nlrp3-inflammasome-activation-and-nf-%C3%AE%C2%BAb-signaling
#19
Chengfu Yuan, Chaoqi Liu, Ting Wang, Yumin He, Zhiyong Zhou, Yaoyan Dun, Haixia Zhao, Dongming Ren, Junjie Wang, Changcheng Zhang, Ding Yuan
Chronic metabolic inflammation in adipose tissue plays an important role in the development of obesity-associated diseases. Our previous study indicated that total saponins of Panax japonicus (SPJ) rhizoma and Chikusetsu saponin V, one main component of SPJ, could exert the anti-oxidative and anti-inflammatory effects. The present study aimed to investigate the in vivo and Ex vivo anti-inflammatory activities of another main component of SPJ, namely Chikusetsu saponin IVa (CS). CS could significantly inhibited HFD-induced lipid homeostasis, and inhibited inflammation in adipose tissue, as reflected by the decreased mRNA expression levels of inflammation-related genes and secretion of the chemokines/cytokines, inhibited the accumulation of adipose tissue macrophages (ATMs) and shifted their polarization from M1 to M2, suppressed HFD-induced expression of NLRP3 inflammasome component genes and decreased IL-1β and Caspase-1 production in mice...
March 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28414763/enhanced-offspring-predisposition-to-steatohepatitis-with-maternal-high-fat-diet-is-associated-with-epigenetic-and-microbiome-alterations
#20
Umesh D Wankhade, Ying Zhong, Ping Kang, Maria Alfaro, Sree V Chintapalli, Keshari M Thakali, Kartik Shankar
OBJECTIVE: Non-alcoholic fatty liver disease (NAFLD) is an important co-morbidity associated with obesity and a precursor to steatohepatitis. However, the contributions of gestational and early life influences on development of NAFLD and NASH remain poorly appreciated. METHODS: Two independent studies were performed to examine whether maternal over-nutrition via exposure to high fat diet (HFD) leads to exacerbated hepatic responses to post-natal HFD and methionine choline deficient (MCD) diets in the offspring...
2017: PloS One
keyword
keyword
75560
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"