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Multiparametric MRI

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https://www.readbyqxmd.com/read/29220213/clinical-application-of-biparametric-mri-texture-analysis-for-detection-and-evaluation-of-high-grade-prostate-cancer-in-zone-specific-regions
#1
Xiang-Ke Niu, Zhi-Fan Chen, Lin Chen, Jun Li, Tao Peng, Xin Li
OBJECTIVE: The purpose of this study was to investigate the performance of biparametric MRI texture analysis (TA) in detecting and evaluating high-grade prostate cancer in zone-specific regions. MATERIALS AND METHODS: A retrospective study included 184 consecutively registered biopsy-naive patients in whom prostate cancer was suspected who were undergoing multiparametric prostate MRI. MR images were scored and evaluated by two readers using the Prostate Imaging Reporting and Data System version 2 (PI-RADSv2) and biparametric MRI TA in separate sessions...
December 8, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29214883/longitudinal-structural-changes-in-als-a-three-time-point-imaging-study-of-white-and-gray-matter-degeneration
#2
Peter Bede, Orla Hardiman
BACKGROUND: Cross-sectional imaging studies offer valuable pathological insights into the neurodegenerative changes of amyotrophic lateral sclerosis. However, clinical trials urgently require sensitive monitoring markers that can detect subtle progressive changes over relatively short periods of time. We have conducted a three time-point longitudinal study to explore anatomical patterns of disease spread and to determine whether MRI metrics capture longitudinal changes over four and eight-month intervals...
December 7, 2017: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
https://www.readbyqxmd.com/read/29211932/targeted-versus-systematic-robot-assisted-transperineal-mri-trus-fusion-prostate-biopsy
#3
J Mischinger, S Kaufmann, G I Russo, N Harland, S Rausch, B Amend, M Scharpf, L Loewe, T Todenhoefer, M Notohamiprodjo, K Nikolaou, A Stenzl, J Bedke, S Kruck
OBJECTIVES: To evaluate the performance of transperineal robot-assisted (RA) targeted (TB) and systematic (SB) prostate biopsy in the primary and repeat biopsy setting. PATIENTS AND METHODS: Patients were admitted to RA biopsy between 2014-2016. Prior to RA-TB, multiparametric (mp) Magnetic Resonance Imaging (MRI) was performed. Prostate lesions were scored (Prostate Imaging, Reporting and Data System Version 2) and used for RA-TB planning. In addition, RA-SB was performed...
December 6, 2017: BJU International
https://www.readbyqxmd.com/read/29205621/multiparametric-characterization-of-response-to-anti-angiogenic-therapy-using-uspio-contrast-enhanced-mri-in-combination-with-dynamic-contrast-enhanced-mri
#4
Jana Kim, Eugene Kim, Leslie R Euceda, Dan E Meyer, Karina Langseth, Tone F Bathen, Siver A Moestue, Else Marie Huuse
BACKGROUND: Steady state susceptibility contrast (SSC)-MRI provides information on vascular morphology but is a rarely used method. PURPOSE: To investigate the utility of the ultrasmall superparamagnetic iron oxide particles (USPIOs) GEH121333 for measuring tumor response to bevacizumab and compare this with gadolinium-based DCE-MRI. STUDY TYPE: Prospective preclinical animal model study. ANIMAL MODEL: Mice bearing subcutaneous TOV-21G human ovarian cancer xenografts treated with bevacizumab (n = 9) or saline (n = 9)...
December 4, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29205162/multiparametric-mri-guided-biopsy-in-the-era-of-precision-medicine
#5
Miguel A Bergero, Pablo F Martínez, Jan P Radtke, Boris A Hadaschik
OBJECTIVE: Technical improvements in prostate magnetic resonance imaging (MRI) have resulted in the use of MRI to target prostate biopsy. This allowed urologists to progress from blind biopsies to target biopsies with a better performance in prostate cancer (PC) diagnosis. We herein review the current status of Magnetic Resonance Imaging Guided Biopsy (MRGB) for the detection of PC. METHODS: A systematic review of the literature was conducted using PubMed, Embase and Cochrane using the search criteria: "PC and MRI/US fusion" or "PC and guided biopsy" or "PC and multiparametric MRI" or "PC and MRI guided prostate biopsy"...
December 2017: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/29203158/are-concurrent-systematic-cores-needed-at-the-time-of-targeted-biopsy-in-patients-with-prior-negative-prostate-biopsies
#6
S Albisinni, F Aoun, A Noel, E El Rassy, M Lemort, M Paesmans, R van Velthoven, T Roumeguère, A Peltier
INTRODUCTION AND OBJECTIVES: MRI-guided targeted biopsies are advised in patients who have undergone an initial series of negative systematic biopsies, in whom prostate cancer (PCa) suspicion remains elevated. The aim of the study was to evaluate whether, in men with prior negative prostate biopsies, systematic cores are also warranted at the time of an MRI-targeted repeat biopsy. MATERIAL AND METHODS: We enrolled patients with prior negative biopsy undergoing real time MRI/TRUS fusion guided prostate biopsy at our institute between 2014 and 2016...
December 1, 2017: Progrès en Urologie
https://www.readbyqxmd.com/read/29201510/the-efficacy-and-utilisation-of-preoperative-multiparametric-magnetic-resonance-imaging-in-robot-assisted-radical-prostatectomy-does-it-change-the-surgical-dissection-plan
#7
Hasan Hüseyin Tavukçu, Ömer Aytaç, Numan Cem Balcı, Haluk Kulaksızoğlu, Fatih Atuğ
Objective: We investigated the effect of the use of multiparametric prostate magnetic resonance imaging (mp-MRI) on the dissection plan of the neurovascular bundle and the oncological results of our patients who underwent robot-assisted radical prostatectomy. Material and methods: We prospectively evaluated 60 consecutive patients, including 30 patients who had (Group 1), and 30 patients who had not (Group 2) mp-MRI before robot-assisted radical prostatectomy. Based on the findings of mp-MRI, the dissection plan was changed as intrafascial, interfascial, and extrafascial in the mp-MRI group...
December 2017: Turkish Journal of Urology
https://www.readbyqxmd.com/read/29201499/biparametric-mri-of-the-prostate
#8
REVIEW
Michele Scialpi, Alfredo D'Andrea, Eugenio Martorana, Corrado Maria Malaspina, Maria Cristina Aisa, Maria Napoletano, Emanuele Orlandi, Valeria Rondoni, Pietro Scialpi, Diamante Pacchiarini, Diego Palladino, Michele Dragone, Giancarlo Di Renzo, Annalisa Simeone, Giampaolo Bianchi, Luca Brunese
Biparametric Magnetic Resonance Imaging (bpMRI) of the prostate combining both morphologic T2-weighted imaging (T2WI) and diffusion-weighted imaging (DWI) is emerging as an alternative to multiparametric MRI (mpMRI) to detect, to localize and to guide prostatic targeted biopsy in patients with suspicious prostate cancer (PCa). BpMRI overcomes some limitations of mpMRI such as the costs, the time required to perform the study, the use of gadolinium-based contrast agents and the lack of a guidance for management of score 3 lesions equivocal for significant PCa...
December 2017: Turkish Journal of Urology
https://www.readbyqxmd.com/read/29198639/baseline-multiparametric-mri-for-selection-of-prostate-cancer-patients-suitable-for-active-surveillance-which-features-matter
#9
Francesco Sanguedolce, Giuseppe Petralia, Heminder Sokhi, Elena Tagliabue, Nicola Anyamene, Giles Hellawell, Anwar R Padhani
INTRODUCTION: Increasing evidence has supported the use of multiparametric magnetic resonance imaging (mpMRI) for the detection of prostate cancer. However, its role in selecting patients clinically suitable for active surveillance (AS) is still in development. We aimed to find relevant mpMRI features that might be helpful for refinement of the selection of low-risk prostate cancer patients for AS. We also evaluated the interobserver variability in reporting prostate mpMRI features. PATIENTS AND METHODS: From 2008 to 2012, 135 patients were selected for AS using Epstein criteria...
November 21, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29197919/prostate-ultrasound-back-in-business
#10
REVIEW
Nicolae Crisan, Iulia Andras, Corina Radu, David Andras, Radu-Tudor Coman, Paul Tucan, Doina Pisla, Dana Crisan, Ioan Coman
The use of grey scale prostate ultrasound decreased after the implementation of magnetic resonance imaging (MRI) for the diagnosis and evaluation of prostate cancer. The new developments, such as multiparametric ultrasound and MRI-ultrasound fusion technology, renewed the interest for this imaging method in the assessment of prostate cancer. The purpose of this paper was to review the current role of prostate ultrasound in the setting of these new applications. A thorough reevaluation of the selection criteria of the patients is required to assess which patients would benefit from multiparametric ultrasound, who wouldbenefit from multiparametric MRI or the combination of both to assist prostate biopsy in order to ensure the balance between overdiagnosis and underdiagnosis of prostate cancer...
November 29, 2017: Medical Ultrasonography
https://www.readbyqxmd.com/read/29195777/multiparametric-magnetic-resonance-imaging-is-an-independent-predictor-of-salvage-radiotherapy-outcomes-after-radical-prostatectomy
#11
REVIEW
Vidit Sharma, Avinash Nehra, Michele Colicchia, Mary E Westerman, Akira Kawashima, Adam T Froemming, Eugene D Kwon, Lance A Mynderse, R Jeffrey Karnes
BACKGROUND: The Stephenson nomogram is widely used to estimate the success of salvage radiotherapy (sXRT) for prostate cancer (PCa) recurrence after radical prostatectomy (RP). OBJECTIVE: To determine whether multiparametric pelvic magnetic resonance imaging (mpMRI) performed for biochemical recurrence after RP improves prognostication of sXRT relative to the Stephenson nomogram. DESIGN, SETTING, AND PARTICIPANTS: Men undergoing RP at our institution from 2003 to 2012 who had biochemical recurrence evaluated by mpMRI within 12 mo of sXRT were retrospectively reviewed...
November 28, 2017: European Urology
https://www.readbyqxmd.com/read/29188489/does-the-prostate-imaging-reporting-and-data-system-pi-rads-version-2-improve-accuracy-in-reporting-anterior-lesions-on-multiparametric-magnetic-resonance-imaging-mpmri
#12
Richard Hoffmann, Callum Logan, Michael O'Callaghan, Kirsten Gormly, Ken Chan, Darren Foreman
INTRODUCTION: Multiparametric MRI (mpMRI) is useful in detecting anterior prostate tumours. Due to the location of anterior tumours, they are often diagnosed with a large size and may be suspicious for extra-prostatic extension (EPE). We aim to evaluate whether PI-RADS v2 is more accurate in assessing anterior prostate lesions identified on mpMRI compared to PI-RADS v1. METHODS: Patients with anterior prostate lesions diagnosed on mpMRI who proceeded to a cognitive fusion transperineal prostate biopsy were identified...
November 29, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/29187481/pre-surgical-multiparametric-assessment-of-breast-lesions-using-3-tesla-magnetic-resonance
#13
Hynek Mirka, Radek Tupy, Andrea Narsanska, Ondrej Hes, Jiri Ferda
BACKGROUND/AIM: The aim of this study was to evaluate experience with multiparametric breast imaging on 3-Tesla magnetic resonance (3T-MRI) scanner using a dedicated 18-channel coil compared to histological findings in women after surgery. MATERIALS AND METHODS: The study included 100 women with 105 Breast Imaging Reporting and Data System (BI-RADS) 4 to 6 lesions by mammography who were examined using 3T-MRI and subsequently underwent surgery. MRI included non-contrast T1, T2 and T2 short tau inversion recovery (STIR) sequences, diffusion-weighted imaging with apparent diffusion coeficient maps, postcontrast dynamic study and single-voxel MRI spectroscopy...
December 2017: Anticancer Research
https://www.readbyqxmd.com/read/29175542/defining-a-cohort-of-men-who-may-not-require-repeat-prostate-biopsy-based-on-pca3-score-and-mri-the-dual-negative-effect
#14
Nathan Perlis, Thamir Al-Kasab, Ardalan Ahmad, Estee Goldberg, Kamel Fadak, Rashid Sayid, Antonio Finelli, Girish Kulkarni, Rob Hamilton, Alexandre Zlotta, Sangeet Ghai, Neil Fleshner
PURPOSE: Prostate Cancer (PCa) overdiagnosis and overtreatment is a concern for clinicians and policy makers. Multiparametric MRI (mpMRI) and the PCA3 urine test select for clinically significant cases. We explore how well the tests perform in combination for men with previous biopsies. MATERIALS AND METHODS: We collected clinicopathologic data from all patients with a PCA3 test from 2011 to June 2016 in accordance with ethics committee approval. This included patients on active surveillance (AS) for low-risk PCa and those without PCa with previous negative biopsies and suspicion of occult disease...
November 23, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29167070/performance-of-ultrafast-dce-mri-for-diagnosis-of-prostate-cancer
#15
Aritrick Chatterjee, Dianning He, Xiaobing Fan, Shiyang Wang, Teodora Szasz, Ambereen Yousuf, Federico Pineda, Tatjana Antic, Melvy Mathew, Gregory S Karczmar, Aytekin Oto
RATIONALE AND OBJECTIVES: This study aimed to test high temporal resolution dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) for different zones of the prostate and evaluate its performance in the diagnosis of prostate cancer (PCa). Determine whether the addition of ultrafast DCE-MRI improves the performance of multiparametric MRI. MATERIALS AND METHODS: Patients (n = 20) with pathologically confirmed PCa underwent preoperative 3T MRI with T2-weighted, diffusion-weighted, and high temporal resolution (~2...
November 20, 2017: Academic Radiology
https://www.readbyqxmd.com/read/29164364/highlights-on-mri-of-the-fetal-body
#16
REVIEW
Lucia Manganaro, Amanda Antonelli, Silvia Bernardo, Federica Capozza, Roberta Petrillo, Serena Satta, Valeria Vinci, Matteo Saldari, Francesca Maccioni, Laura Ballesio, Carlo Catalano
Fetal MRI is a level III diagnostic tool performed subsequently a level II prenatal ultrasound (US), in cases of inconclusive ultrasonographic diagnosis or when a further investigation is required to confirm or improve the diagnosis, to plan an appropriate pregnancy management. Fetal MRI plays an increasingly important role in the prenatal diagnosis of fetal neck, chest and abdominal malformations, even if its role has been amply demonstrated, especially, in the field of fetal CNS anomalies. Due to its multiparametricity and multiplanarity, MRI provides a detailed evaluation of the whole fetal respiratory, gastrointestinal and genitourinary systems, especially on T2-weighted (W) images, with a good tissue contrast resolution...
November 21, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/29164056/prostate-cancer-imaging-and-biomarkers-guiding-safe-selection-of-active-surveillance
#17
REVIEW
Zachary A Glaser, Jennifer B Gordetsky, Kristin K Porter, Sooryanarayana Varambally, Soroush Rais-Bahrami
Background: Active surveillance (AS) is a widely adopted strategy to monitor men with low-risk, localized prostate cancer (PCa). Current AS inclusion criteria may misclassify as many as one in four patients. The advent of multiparametric magnetic resonance imaging (mpMRI) and novel PCa biomarkers may offer improved risk stratification. We performed a review of recently published literature to characterize emerging evidence in support of these novel modalities. Methods: An English literature search was conducted on PubMed for available original investigations on localized PCa, AS, imaging, and biomarkers published within the past 3 years...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/29159467/the-use-of-multiparametric-quantitative-magnetic-resonance-imaging-for-evaluating-visually-assigned-lesion-groups-in-patients-with-multiple-sclerosis
#18
Christian Thaler, Tobias D Faizy, Jan Sedlacik, Maxim Bester, Jan-Patrick Stellmann, Christoph Heesen, Jens Fiehler, Susanne Siemonsen
In multiple sclerosis (MS), inflammatory lesions present a broad spectrum of histopathologic processes. For a better discrimination, lesions are visually defined into different lesion groups according to their appearance on conventional magnetic resonance imaging (MRI). The aim of this study was to investigate the properties of different MS lesion groups using multiparametric quantitative MRI. 35 patients diagnosed with relapsing-remitting MS received 3 Tesla MRI including magnetization-prepared 2 rapid acquisition gradient echo, diffusion tensor imaging and magnetization transfer imaging...
November 20, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29153465/impact-of-hybrid-pet-mr-technology-on-multiparametric-imaging-and-treatment-response-assessment-of-cervix-cancer
#19
Michaela Daniel, Piotr Andrzejewski, Alina Sturdza, Katarina Majercakova, Pascal Baltzer, Katja Pinker, Wolfgang Wadsak, Markus Mitterhauser, Richard Pötter, Petra Georg, Thomas Helbich, Dietmar Georg
BACKGROUND AND PURPOSE: Multimodal tissue characterization by combined MRI and PET has high clinical potential in the context of sub-target definition for dose painting and response assessment but its clinical exploration is yet limited. The aim of this study was to prove the potential and feasibility of hybrid PET/MRI to non-invasively measure tumor hypoxia, perfusion and microstructure at one stop in tumors of the uterine cervix during chemoradiotherapy. MATERIAL AND METHODS: Ten cervix cancer patients were subjected to simultaneous multiparametric PET/MRI with [(18)F]fluoromisonidazole ([(18)F]FMISO)...
November 15, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29152563/integrated-radiomic-framework-for-breast-cancer-and-tumor-biology-using-advanced-machine-learning-and-multiparametric-mri
#20
Vishwa S Parekh, Michael A Jacobs
Radiomics deals with the high throughput extraction of quantitative textural information from radiological images that not visually perceivable by radiologists. However, the biological correlation between radiomic features and different tissues of interest has not been established. To that end, we present the radiomic feature mapping framework to generate radiomic MRI texture image representations called the radiomic feature maps (RFM) and correlate the RFMs with quantitative texture values, breast tissue biology using quantitative MRI and classify benign from malignant tumors...
2017: NPJ Breast Cancer
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