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extrapulmonary tuberculosis

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https://www.readbyqxmd.com/read/28817675/deaths-during-tuberculosis-treatment-among-paediatric-patients-in-a-large-tertiary-hospital-in-nigeria
#1
Aishatu L Adamu, Muktar H Aliyu, Najiba Aliyu Galadanci, Baba Maiyaki Musa, Muktar A Gadanya, Auwalu U Gajida, Taiwo G Amole, Imam W Bello, Safiya Gambo, Ibrahim Abubakar
BACKGROUND: Despite availability of effective cure, tuberculosis (TB) remains a leading cause of death in children. In many high-burden countries, childhood TB is underdiagnosed and underreported, and care is often accessed too late, resulting in adverse treatment outcomes. In this study, we examined the time to death and its associated factors among a cohort of children that commenced TB treatment in a large treatment centre in northern Nigeria. METHODS: This is a retrospective cohort study of children that started TB treatment between 2010 and 2014...
2017: PloS One
https://www.readbyqxmd.com/read/28810312/-analysis-of-infection-and-drug-resistance-in-6-107-cases-of-extrapulmonary-tuberculosis-in-chengdu-area
#2
D M Wang, Q F Li, M Zhu, Y H Xu, J Luo, Y J Li, J Zhong, Z J Wu
Objective: To analyze the infection and drug resistance of extrapulmonary tuberculosis, in order to provide useful references for prevention and treatment of tuberculosis (TB). Methods: A total of 6 107 suspected cases of extrapulmonary tuberculosis, including lymph node, pleural, peritoneal, meningeal, urinary tract, and bone tuberculosis, were collected retrospectively from January 2013 to December 2015 in Public Health Clinical Center of Chengdu. There were 4 033 male and 2 074 female patients, and the average age was 37 years...
August 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28802406/real-time-pcr-followed-by-high-resolution-melting-curve-analysis-a-rapid-and-pragmatic-approach-for-screening-of-multidrug-resistant-extrapulmonary-tuberculosis
#3
Kusum Sharma, Megha Sharma, Shreya Singh, Manish Modi, Aman Sharma, Pallab Ray, Subhash Varma
INTRODUCTION: Multidrug resistance (MDR) in extrapulmonary tuberculosis (EPTB) is a diagnostic challenge in an endemic country like India. Timely detection of MDR-TB can contribute to a better patient outcome. OBJECTIVE: To perform real-time PCR (qPCR) using rpoB, mpb64 and IS6110 gene on a variety of EPTB samples and to compare the performance of different gene targets. All qPCR positive samples were subjected to high resolution melt-curve analysis (HRM analysis) for rpoB and katG gene to evaluate its potential for MDR screening among different sample types...
September 2017: Tuberculosis
https://www.readbyqxmd.com/read/28798995/splenic-tuberculosis-and-multifocal-serpiginoid-choroiditis
#4
Pradeep Kumar, Prateek Kakkar, Raghav Ravani, R Karthikeya, Atul Kumar
Serpiginoid multifocal choroiditis is a distinct morphological identity with a reported causal association with Mycobacterium tuberculosis. We report a case of serpiginoid multifocal choroiditis in a 17-year-old boy who was suffering from isolated splenic tuberculosis. He was treated with systemic steroids along with anti-tubercular treatment with good visual recovery. This case was unique as no other organs except spleen and choroid showed tubercular involvement. We hereby emphasize association of extrapulmonary sites with multifocal serpiginoid choroiditis and propose a thorough investigation for primary to be included in routine protocol of choroiditis workup...
August 10, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28776534/recovery-of-mycobacterium-lentiflavum-from-bronchial-lavage-during-follow-up-of-an-extrapulmonary-tuberculosis-patient
#5
Esther Vise, Michael Mawlong, Akshay Garg, Arnab Sen, Ingudam Shakuntala, Samir Das
Initially diagnosed with cervical lymphadenitis, a 15-year-old boy was started with category I anti-tuberculosis (TB) drugs. Follow-up investigations led to isolation and identification of Mycobacterium lentiflavum by multiple diagnostic and identification approaches. Observation of this rare pathogen from human origin urges cautious diagnosis while attending TB cases.
July 2017: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28776524/pulmonary-tuberculosis-in-a-pediatric-reference-hospital-in-bogot%C3%A3-colombia
#6
Luisa Fernanda Imbachí Yunda, Eileen Viviana Fonseca Sepúlveda, Kelly Christina Márquez Herrera, Germán Camacho Moreno
BACKGROUND: In Colombia, epidemiological and clinical information related to pediatric tuberculosis (TB) is scarce. Data are needed to define the impact of the disease and to strengthen measures for detection and treatment. It is proposed to analyze the pediatric population diagnosed with pulmonary TB in a national reference institution. METHODS: Retrospective observational study including pediatric patients with pulmonary and miliary TB, and pulmonary and extrapulmonary involvement, treated between January 1, 2008 and December 31, 2016...
July 2017: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28774293/the-clinical-utility-of-the-urine-based-lateral-flow-lipoarabinomannan-assay-in-hiv-infected-adults-in-myanmar-an-observational-study
#7
Swe Swe Thit, Ne Myo Aung, Zaw Win Htet, Mark A Boyd, Htin Aung Saw, Nicholas M Anstey, Tint Tint Kyi, David A Cooper, Mar Mar Kyi, Josh Hanson
BACKGROUND: The use of the point-of-care lateral flow lipoarabinomannan (LF-LAM) test may expedite tuberculosis (TB) diagnosis in HIV-positive patients. However, the test's clinical utility is poorly defined outside sub-Saharan Africa. METHODS: The study enrolled consecutive HIV-positive adults at a tertiary referral hospital in Yangon, Myanmar. On enrolment, patients had a LF-LAM test performed according to the manufacturer's instructions. Clinicians managing the patients were unaware of the LF-LAM result, which was correlated with the patient's clinical course over the ensuing 6 months...
August 4, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28764227/portal-venous-thrombosis-disseminated-tuberculosis-in-rheumatoid-arthritis
#8
Vasanthi Natarajan, Kevin John, David Jose, Pradeep Kalaiselvan, Ashok Kumar Das
Vascular thrombosis is one of the complications of tuberculosis. Deep vein thrombosis and pulmonary thrombosis have been reported with pulmonary and extrapulmonary tuberculosis. Splenic involvement in abdominal tuberculosis is among the rarest manifestations. Disseminated tuberculosis is predominantly reported in rheumatoid arthritis following ingestion of biological agents. Here, we report a case of disseminated tuberculosis in a rheumatoid arthritis patient who was on steroids and methotrexate for a long period, presenting with multiple splenic lesion and portal vein thrombosis, which was not reported earlier...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28761842/cutaneous-squamous-cell-carcinoma-in-lupus-vulgaris-caused-by-drug-resistant-mycobacterium-tuberculosis
#9
Muthu S Kumaran, Tarun Narang, Madhukara Jitendriya, Rajalakshmi Tirumale, Suraj Manjunath, Jayanthi Savio
Tuberculosis (TB) is still a major public health problem in the world, with many factors contributing to this burden, including poor living conditions, overcrowding, poverty, malnutrition, illiteracy, and rapid spread of human immunodeficiency virus infection. Cutaneous tuberculosis is a less common form of extrapulmonary tuberculosis, and in this paucibacillary form the diagnosis depends on histopathology, tuberculin positivity, and response to treatment. The diagnosis is even more difficult in cases with drug resistant Mycobacterium tuberculosis due to lack of awareness and lack of facilities to diagnose drug resistant tuberculosis...
July 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/28761620/-swelling-of-the-pectoralis-muscle-revealing-isolated-muscular-tuberculosis
#10
Sohaib Hayoun, Hanane El Ouazzani, Bouchra Habibi, Salwa Belhabib, Hicham Souhi, Ismail Abderahmane Rhorfi, Ahmed Abid
Soft tissue tuberculosis is one of the rare forms of extrapulmonary tuberculosis. Furthermore, isolated muscular tuberculosis is exceptional. We here report the original case of a young immunocompetent patient with isolated muscular tuberculosis involving major pectoralis muscle. The diagnosis was mainly based on histology. The patient was successfully treated with anti bacterial therapy only. This rare case study has been combined with a literature review.
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28748883/epidemiology-and-outcome-of-tuberculosis-in-immunocompromised-patients
#11
Abdul Massiah Metry, Issa Al Salmi, Seif Al-Abri, Faisal Al Ismaili, Yaqoub Al Mahrouqi, Alan Hola, Faissal A M Shaheen
The United States Renal Data System showed 1.2% and 1.6% incidences of tuberculosis (TB) in patients on peritoneal dialysis and hemodialysis (HD), respectively. Kidney transplant (KTX) patients have higher rates. We studied the epidemiology and outcome of TB in patients with kidney dysfunction in a tertiary care hospital in the past decade. We examined data of patients with TB with and without kidney dysfunction from 2006 to 2015 through an electronic system. Statistical analysis was completed using Stata software, Chicago, IL, USA...
July 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28748775/reduction-in-extrapulmonary-tuberculosis-in-context-of-antiretroviral-therapy-scale-up-in-rural-south-africa
#12
J C Hoogendoorn, L Ranoto, N Muditambi, J Railton, M Maswanganyi, H E Struthers, J A McIntyre, R P H Peters
Scale-up of antiretroviral therapy (ART) for human immunodeficiency virus (HIV) infection has reduced the incidence of pulmonary tuberculosis (PTB) in South Africa. Despite the strong association of HIV infection with extrapulmonary tuberculosis (EPTB), the effect of ART on the epidemiology of EPTB remains undocumented. We conducted a retrospective record review of patients initiated on treatment for EPTB in 2009 (ART coverage <5%) and 2013 (ART coverage 41%) at four public hospitals in rural Mopani District, South Africa...
September 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28748193/infliximab-therapy-leading-to-pulmonary-tuberculosis-in-a-patient-with-negative-interferon-%C3%AE-release-assay-igra-based-quantiferon-gold-test
#13
Soni Parita, Kumar Vivek, Kamholz Stephan, Pascal William, Kupfer Yizhak
Infliximab therapy is associated with higher rates of active tuberculosis (TB), particularly extrapulmonary and disseminated forms with unusual symptoms. We report the case of a 66-year-old man with Crohn's disease who developed TB mimicking lung cancer on imaging. He presented with cough and fever of 2 weeks' duration shortly after starting infliximab. Computed tomography of the chest revealed a 7.0 × 3.2 cm(2) pleural-based mass, highly suspicious for malignancy. Histopathological examination confirmed the diagnosis of TB...
July 2017: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/28748004/-dorsolumbar-cold-abscess-revealing-pott-s-disease
#14
Kouame Jean-Eric Kouassi, Loukou Blaise Yao, Bada Justin Léopold Niaore Sery, Kouamé Innocent M'bra, Koffi Léopold Krah, Grah Franck Lohourou, Michel Kodo
Tuberculous cold abscesses are a rare and unusual form of extrapulmonary tuberculosis. We here report the case of a 27-year old patient with a 5-month history of left dorsolumbar swelling presenting with dorsolumbar cold abscess revealing Pott's disease without neurological complications. Examination of pus sample collected at the time the abscess was incised and drained helped to confirm the diagnosis of cold abscesses of TB origin. The patient underwent 12 months of anti-tuberculosis treatment which lead to a faster recovery; the sequelae was slight gibbosity...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28739268/xpert%C3%A2-mtb-rif-usefulness-for-the-diagnosis-of-tuberculosis-and-resistance-to-rifampicin
#15
REVIEW
Andrea Vergara Gómez, Julià González-Martín, Alberto L García-Basteiro
The advent of the Xpert® MTB/RIF technique was a revolution in the diagnosis of tuberculosis, especially in areas with high incidence and low resources. It allows the detection of Mycobacterium tuberculosis complex and simultaneously the most common resistance mutations to rifampicin in less than 2h. For respiratory samples the sensitivity is very high, but it decreases for extrapulmonary samples and children. Although it is faster and simpler than conventional methods, it presents some limitations and new and better techniques are needed to reduce the number of cases and deaths caused by tuberculosis...
July 21, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28708053/rapid-diagnosis-of-extrapulmonary-tuberculosis-with-xpert-mycobacterium-tuberculosis-rifampicin-assay
#16
Yan Li, Yu Pang, Tianhua Zhang, Xiaoping Xian, Xidi Wang, Jian Yang, Rui Wang, Meiling Chen, Wei Chen
PURPOSE: XpertMycobacterium tuberculosis/rifampicin (Xpert MTB/RIF) assay has been endorsed by the World Health Organization (WHO) for diagnosis of extrapulmonary tuberculosis (EPTB), while the sensitivity and specificity have not been fully evaluated. We aimed to evaluate the performance of Xpert MTB/RIF assay in the detection of different extrapulmonary specimens. METHODS: A total of 420 nonrespiratory specimens were detected with acid-fast bacilli (AFB) smear microscopy, solid culture, conventional drug susceptibility testing (DST) and Xpert MTB/RIF assay...
July 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28701832/tuberculous-mastitis-diagnosed-on-cytology-case-report-of-a-rare-entity
#17
Riti Tushar Kanti Sinha, Aniruna Dey, Seema Agarwal
Tuberculous mastititis is a rare clinical entity and usually affects women from the Indian subcontinent. It often mimics breast carcinoma and pyogenic breast abscess. Fine needle aspiration cytology (FNAC) is a very essential diagnostic tool when other routine laboratory investigations are not helpful in reaching to the conclusion. Tuberculosis (TB) of the breast is an uncommon presentation of TB even in countries where the incidence of pulmonary and extrapulmonary TB is high. Radiological imaging is not diagnostic...
July 2017: Journal of Cytology
https://www.readbyqxmd.com/read/28692415/whole-genome-sequencing-of-mycobacterium-tuberculosis-isolates-from-extrapulmonary-sites
#18
Kusum Sharma, Renu Verma, Jayshree Advani, Oishi Chatterjee, Hitendra S Solanki, Aman Sharma, Subhash Varma, Manish Modi, Pallab Ray, Kanchan K Mukherjee, Megha Sharma, Mandeed Singh Dhillion, Mrutyunjay Suar, Aditi Chatterjee, Akhilesh Pandey, Thottethodi Subrahmanya Keshava Prasad, Harsha Gowda
Tuberculosis (TB) remains one of the leading causes of morbidity and mortality worldwide. Extrapulmonary tuberculosis (EPTB) constitutes around 15-20% of TB cases in immunocompetent individuals. Extrapulmonary sites that are affected by TB include bones, lymph nodes, meningitis, pleura, and genitourinary tract. Whole genome sequencing has emerged as a powerful tool to map genetic diversity among Mycobacterium tuberculosis (MTB) isolates and identify the genomic signatures associated with drug resistance, pathogenesis, and disease transmission...
July 2017: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/28691438/hiv-viral-load-as-an-independent-risk-factor-for-tuberculosis-in-south-africa-collaborative-analysis-of-cohort-studies
#19
Lukas Fenner, Andrew Atkinson, Andrew Boulle, Matthew P Fox, Hans Prozesky, Kathrin Zürcher, Marie Ballif, Hansjakob Furrer, Marcel Zwahlen, Mary-Ann Davies, Matthias Egger
INTRODUCTION: Chronic immune activation due to ongoing HIV replication may lead to impaired immune responses against opportunistic infections such as tuberculosis (TB). We studied the role of HIV replication as a risk factor for incident TB after starting antiretroviral therapy (ART). METHODS: We included all HIV-positive adult patients (≥16 years) in care between 2000 and 2014 at three ART programmes in South Africa. Patients with previous TB were excluded. Missing CD4 cell counts and HIV-RNA viral loads at ART start (baseline) and during follow-up were imputed...
June 23, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28690879/epidemiological-characteristics-and-clinical-outcome-of-hiv-related-tuberculosis-in-a-population-of-tb-patients-in-south-western-nigeria
#20
Olugbenga A Olowe, Olufunmilola B Makanjuola, Adeniyi S Adekanmi, Olusola J Adefioye, Rita A Olowe
Tuberculosis (TB) is the second leading cause of death from infectious disease globally with its impact more dramatic in resource limited settings. Individuals with human immunodeficiency virus (HIV) infection who also develop tuberculosis represent a significant challenge to TB control. This study was carried out to determine the prevalence of TB-HIV coinfection and pattern of infection among TB patients. We also compared treatment outcome among coinfected patients with those not coinfected. A six-year retrospective review of records of patients managed at the Tuberculosis Treatment Center of the LAUTECH Teaching Hospital, South-Western Nigeria from January 2009 to December 2014 was carried out...
June 2017: European Journal of Microbiology & Immunology
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