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extrapulmonary tuberculosis

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https://www.readbyqxmd.com/read/29228220/the-burden-of-presumed-tuberculosis-in-hospitalized-children-in-a-resource-limited-setting-in-papua-new-guinea-a-prospective-observational-study
#1
Villa Watch, Jimmy Aipit, Tina Kote-Yarong, Allanie Rero, John W Bolnga, Elvin Lufele, Moses Laman
Background: In Papua New Guinea, TB is considered to be a major public health problem, but little is known about the prevalence and prognosis of presumed TB in children. Methods: As part of a prospective hospital-based surveillance on the northern coast of mainland Papua New Guinea, the authors investigated the admission prevalence and case fatality rate associated with presumed TB over a 6-year period (2011-2016). All children admitted who were diagnosed with TB were followed-up until discharge or death...
December 8, 2017: International Health
https://www.readbyqxmd.com/read/29225973/molecular-epidemiology-of-rifampicin-resistance-in-mycobacterium-tuberculosis-using-the-genexpert-mtb-rif-assay-from-a-rural-setting-in-india
#2
Raghuprakash Reddy, Gerardo Alvarez-Uria
The Xpert MTB/RIF assay can detect mutations in rpoB gene that confer rifampicin resistance (RR) using five overlapping probes (A, B, C, D, and E). In this study, we described our experience with the Xpert assay in a rural setting in India. During the study period, 3250 samples were processed. The result was unsuccessful in 5.7% of cases. For extrapulmonary specimens, the risk of unsuccessful result was higher in tissue biopsy and stool samples. Among samples positive for Mycobacterium tuberculosis, rifampicin resistance was indeterminate in 1...
2017: Journal of Pathogens
https://www.readbyqxmd.com/read/29217910/primary-tubercular-abscess-of-the-axilla-a-rare-case
#3
Ameet Kumar, T S Ramakrishnan, Samaresh Sahu
Tuberculosis can be broadly classified as pulmonary and extrapulmonary. Though pulmonary tuberculosis is the most common presentation, extrapulmonary tuberculosis is also an important entity. A tubercular cold abscess secondary to involvement of an adjacent bone or suppuration of lymph nodes is a well-known entity; however, a primary cold abscess is rare. We report a case of a young girl who presented with an axillary swelling which turned out to be a primary tubercular abscess of the axilla. To the best of our knowledge, this is the first reported case of a primary tubercular abscess presenting in the axilla...
December 2017: Indian Journal of Surgery
https://www.readbyqxmd.com/read/29204339/chest-pain-in-a-young-immunocompetent-male-a-rare-case-scenario
#4
M D Badusha, Ramanjula Reddy, Konathala Phani Kumar, Satyasri
Musculoskeletal tuberculosis is the commonest form of extrapulmonary tuberculosis however Rib lesion is uncommon and occurs in zero to five percent of bone and joint tuberculosis. In our case report both chest X ray and CT were useful in demonstrating the skeletal lesion and also in the assessment of response to treatment, as follow up chest X ray and CT scan at 4 months and after 12 months of anti tubercular drugs showed remarkable new bone formation and clearing of pleura parenchymal lesions.
2018: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/29200700/extrapulmonary-tuberculosis-of-lymph-node-coexist-with-diffuse-large-b-cell-lymphoma-a-case-report
#5
Sashi Bhusan Dash, Upasna Das, Niranjan Rout, Sasmita Panda
Extrapulmonary tuberculosis (TB) coexistent with lymphomas in the same organ are rare. Here, we report a case of a 14-year-old male patient who had cauliflower-like ulcerated mass over cervical lymphadenopathy. He was diagnosed extrapulmonary TB. Unresponsiveness of anti tubercular treatment (anti-tubercular) treatment after 6 months, he was diagnosed as diffuse large B-cell lymphoma.
July 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/29182223/tuberculosis-in-poland-in-2015
#6
Maria Korzeniewska-Koseła
AIM OF THE STUDY: To evaluate the main features of TB epidemiology in 2015 in Poland and to compare with the data on the same phenomena in the EU/EEA countries. METHODS: Analysis of case – based data on TB patients from National TB Register, data on anti-TB drug susceptibility testing results in cases notified in 2015, data from National Institute of Public Health- National Institute of Hygiene on cases of tuberculosis as AIDS-defining disease, data from Central Statistical Office on deaths from tuberculosis based on death certificates, data from ECDC report „ European Centre for Disease Prevention and Control/WHO Regional Office for Europe...
2017: Przegla̧d Epidemiologiczny
https://www.readbyqxmd.com/read/29173987/epidemiological-clinical-microbiological-and-therapeutic-differences-in-tuberculosis-disease-in-patients-with-and-without-hiv-infection
#7
Javier Martínez-Sanz, María Rosa Lago-Gómez, María Elena Rodríguez-Zurita, Esteban Martín-Echevarría, Miguel Torralba
BACKGROUND AND OBJECTIVE: Our objective is to analyze the incidence of tuberculosis (TB) in our population and to compare the characteristics of patients with and without HIV infection. PATIENTS AND METHODS: Clinical-epidemiological retrospective cohort study that included patients diagnosed with TB with and without HIV infection between 2005-2016 in the province of Guadalajara (Spain). Epidemiological, clinical, microbiological and therapeutic variables were assessed, including microbiological resistances...
November 22, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/29171454/nontuberculous-mycobacteria-in-clinical-samples-with-negative-acid-fast-bacilli
#8
Alejandro Hernandez-Solís, Raúl Cicero-Sabido, Maribel González-Villa, Isaura Isabel Martínez-Rivera, América Del Pilar Mandujano-Martínez, Benita Pilar Torres-Mazadiego, Claudia Elena Wong-Arámbula, Abril Paulina Rodríguez-Maldonado, Lucia Hernández-Rivas, Heleodora González-González, José Ernesto Ramírez-González
BACKGROUND: There is a progressive increase in nontuberculous mycobacteria (NTM) in pulmonary and extrapulmonary infections that might cause confusion with the Mycobacterium tuberculosis complex. To determine the frequency of finding NTM in clinical samples from patients diagnosed with active tuberculosis, with negative acid-alcohol-resistant bacilli (acid-fast bacillus [AFB]) in a third-level specialty hospital's mycobacterial laboratory between January 2013 and December 2014. METHODS: This is a prospective, descriptive study where isolated strains of biological material were studied in Lowenstein-Jensen and BACTEC MGIT 960 cultures...
October 2017: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/29169641/treatment-of-pulmonary-and-extrapulmonary-tuberculosis
#9
José Francisco Pascual-Pareja, Raquel Carrillo-Gómez, Victor Hontañón-Antoñana, Mónica Martínez-Prieto
The purpose of tuberculosis treatment is twofold: to provide an individual benefit centred on healing the patient with TB, and to provide a collective benefit to the community in which the patient resides. The different treatment regimens for tuberculosis sensitive to first-line antituberculosis drugs as well as resistant tuberculosis are examined and the peculiarities in the management of pulmonary and extrapulmonary tuberculosis are discussed.
November 20, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/29166408/estimating-the-impact-of-tuberculosis-anatomical-classification-on-treatment-outcomes-a-patient-and-surveillance-perspective-analysis
#10
Otavio T Ranzani, Laura C Rodrigues, Eliseu A Waldman, Carlos R R Carvalho
INTRODUCTION: Tuberculosis anatomical classification is inconsistent in the literature, which limits current tuberculosis knowledge and control. We aimed to evaluate whether tuberculosis classification impacts on treatment outcomes at patient and aggregate level. METHODS: We analyzed adults from São Paulo State, Brazil with newly diagnosed tuberculosis from 2010-2013. We used an extended clinical classification of tuberculosis, categorizing cases as pulmonary, pulmonary and extrapulmonary, extrapulmonary and miliary/disseminated...
2017: PloS One
https://www.readbyqxmd.com/read/29165702/trend-of-tuberculosis-case-notification-and-treatment-outcome-in-lagos-state-nigeria-a-5-year-retrospective-study
#11
Olusola A Adejumo, Olusoji J Daniel, Husseine A Abdur-Razzaq, Yeside O Shogbamimu, Toriola Femi-Adebayo, Victor A Adepoju, Bisola I Adebayo, Oluwajimi O Sodipo
Background: This study assessed trends of tuberculosis (TB) case notification rate (CNR) and treatment outcomes between 2011 and 2015 in Lagos State, Nigeria. Methods: A retrospective review of TB notification data to the Lagos State Tuberculosis and Leprosy Control Programme (LSTBLCP) between 1 January 2011 and 31 December 2015 was conducted. Results: A total of 44 516 TB cases were notified during the study period, representing 9.4% of the national figure...
November 20, 2017: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29164169/tuberculosis-patients-who-are-a-potential-source-for-unprotected-exposure-in-health-care-systems-a-multicenter-case-control-study
#12
Jose Cadena, Norys A Castro-Pena, Heta Javeri, Brian Hernandez, Joel Michalek, Ana Fuentes Arzola, Miloni Shroff, Chetan Jinadatha, Gustavo Valero, Jason Bowling, Jean Przykucki, Michele Adams, James Jorgensen, Jan E Patterson, Pranavi Sreeramoju
Setting: Five health care systems in Texas. Objective: To describe the epidemiology of inadequate isolation for pulmonary tuberculosis leading to tuberculosis (TB) exposures from confirmed TB patients and the patient factors that led to the exposures. Design: A retrospective cohort and case-control study of adult patients with TB resulting in exposures (cases) vs those TB patients who did not result in exposures (controls) during January 2005 to December 2012...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29160524/a-fatal-case-of-tuberculous-meningitis-in-a-child-with-juvenile-idiopathic-arthritis-a-diagnostic-challenge
#13
Zumrut Sahbudak Bal, Pinar Yazici, Semra Sen, Cenk Eraslan, Cengiz Cavusoglu, Bulent Karapinar, Fadil Vardar
The prognosis of tuberculous meningitis, a rare form of extrapulmonary tuberculosis, depends on the stage of treatment initiation. We report a fatal case of tuberculous meningitis. The patient had received successive tumor necrosis factor (TNF) antagonists and abatacept to treat juvenile idiopathic arthritis, with negative results for polymerase chain reaction and acid-fast bacilli on smear, had normal cerebrospinal fluid (CSF) adenosine deaminase and glucose levels. Six weeks post-admission, the CSF culture demonstrated Mycobacterium tuberculosis...
September 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29155819/determinants-of-site-of-tuberculosis-disease-an-analysis-of-european-surveillance-data-from-2003-to-2014
#14
Giovanni Sotgiu, Dennis Falzon, Vahur Hollo, Csaba Ködmön, Nicolas Lefebvre, Andrei Dadu, Marieke van der Werf
BACKGROUND: We explored host-related factors associated with the site of tuberculosis (TB) disease using variables routinely collected by the 31 EU/EEA countries for national surveillance. METHODS: Logistic regression models were fitted to case-based surveillance data reported to the European Centre for Disease Prevention and Control for TB cases notified from 2003 to 2014. Missing data on HIV infection and on susceptibility to isoniazid and rifampicin for many patients precluded the inclusion of these variables in the analysis...
2017: PloS One
https://www.readbyqxmd.com/read/29154831/detection-of-mycobacterium-tuberculosis-derived-dna-in-circulating-cell-free-dna-from-a-patient-with-disseminated-infection-with-digital-pcr
#15
Masaki Yamamoto, Ryota Ushio, Hiroki Watanabe, Takayoshi Tachibana, Masatsugu Tanaka, Tomoyuki Yokose, Jun Tsukiji, Hideaki Nakajima, Takeshi Kaneko
Mycobacterium tuberculosis (MTB) can disseminate to extra-pulmonary organs, particularly in severely immunosuppressed patients. Confirmation of active MTB infection is often difficult in subjects with contraindication for invasive procedures. We herein report a case of disseminated MTB infection after hematopoietic stem cell transplantation. Circulating cell free DNA of the patient showed positive amplification for a MTB complex specific sequence using digital PCR technique. MTB infection could be confirmed with positive acid fast stain and approved quantitative PCR assay using the liver tissue obtained at an autopsy...
November 14, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29147157/tuberculous-mycotic-aneurysm-of-common-iliac-artery-secondary-from-ureteric-tuberculosis-the-first-case-report-and-review-of-the-literature
#16
Patchara Paraksa, Benjawan Skulsujirapa, Chusana Suankratay
Extrapulmonary involvement of tuberculosis occurs in 10-40% of reported cases. However, tuberculous mycotic aneurysm is very rare. We report herein tuberculous mycotic aneurysm of left common iliac artery secondary from ureteric tuberculosis in a 63-year-old man who presented with left flank pain for 1 month, and review the literature of all reported cases of tuberculous aneurysm of iliac artery.
September 25, 2017: Annals of Vascular Diseases
https://www.readbyqxmd.com/read/29141727/point-of-care-ultrasound-for-extrapulmonary-tuberculosis-in-india-a-prospective-cohort-study-in-hiv-positive-and-hiv-negative-presumptive-tuberculosis-patients
#17
Stefan F Weber, Kavitha Saravu, Tom Heller, Rajagopal Kadavigere, Shashidhar Vishwanath, Stephan Gehring, Sabine Bélard, And Pocus Eti Study Group
Diagnosing extrapulmonary tuberculosis (EPTB) is challenging. Point-of-care ultrasound (POCUS) for human immunodeficiency virus (HIV)-associated EPTB is applied in sub-Saharan Africa. This study aimed at evaluating the applicability of POCUS for diagnosing EPTB in HIV-positive and HIV-negative presumptive tuberculosis (TB) patients in India, a country of moderate relative TB and HIV burden. Presumptive TB patients at Kasturba Hospital, Manipal, India, prospectively underwent POCUS evaluating for pericardial, pleural and ascitic effusion, abdominal lymphadenopathy, and hepatic and splenic microabscesses...
October 16, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29140996/childhood-tuberculosis-is-associated-with-decreased-abundance-of-t-cell-gene-transcripts-and-impaired-t-cell-function
#18
Cheryl Hemingway, Maurice Berk, Suzanne T Anderson, Victoria J Wright, Shea Hamilton, Hariklia Eleftherohorinou, Myrsini Kaforou, Greg M Goldgof, Katy Hickman, Beate Kampmann, Johan Schoeman, Brian Eley, David Beatty, Sandra Pienaar, Mark P Nicol, Michael J Griffiths, Simon J Waddell, Sandra M Newton, Lachlan J Coin, David A Relman, Giovanni Montana, Michael Levin
The WHO estimates around a million children contract tuberculosis (TB) annually with over 80 000 deaths from dissemination of infection outside of the lungs. The insidious onset and association with skin test anergy suggests failure of the immune system to both recognise and respond to infection. To understand the immune mechanisms, we studied genome-wide whole blood RNA expression in children with TB meningitis (TBM). Findings were validated in a second cohort of children with TBM and pulmonary TB (PTB), and functional T-cell responses studied in a third cohort of children with TBM, other extrapulmonary TB (EPTB) and PTB...
2017: PloS One
https://www.readbyqxmd.com/read/29137108/tuberculosis-presenting-as-isolated-bronchonodal-fistula-in-a-patient-with-systemic-lupus-erythematosus-case-report
#19
Kyungsoo Bae, Kyung Nyeo Jeon, Ho Cheol Kim, Young Sun Suh, Gi Dong Lee, Ju-Young Kim, Dae Hyun Song
RATIONALE: Lymph node is a preferred site for extrapulmonary tuberculosis (TB). In the thorax, mediastinal tuberculous lymph nodes can erode adjacent structures such as heart, aorta, and esophagus, forming fistula, and causing fatal consequences. However, tuberculous bronchonodal fistula as a complication of lymph node TB in adults is rarely known in terms of imaging or clinical findings. Here, a case of isolated tuberculous bronchonodal fistula appearing as the first presentation of TB in a 74-year-old male with systemic lupus erythematosus (SLE) is reported...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29128024/mycobacterial-infections-in-solid-organ-and-hematopoietic-stem-cell-transplantation
#20
REVIEW
Tahuanty Pena, Julia Klesney-Tait
Mycobacterial infections are uncommon in solid organ and hematopoietic stem cell transplant recipients but carry significant morbidity and mortality. Donor screening strategies for tuberculosis should be emphasized in high-risk populations. Both tuberculosis and nontuberculous mycobacterial infections can have pulmonary and extrapulmonary manifestations of infections. Recommended treatment regimens typically involve multiple drugs with significant adverse effects and drug interactions.
December 2017: Clinics in Chest Medicine
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