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extrapulmonary tuberculosis

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https://www.readbyqxmd.com/read/28630849/a-case-of-chronic-inflammation-of-the-ankle-joint-with-subtle-signs-of-inflammation-a-rare-presentation-of-tuberculosis-ankle
#1
Jeevan Pereira, S Anoop, George Joy Pettah
INTRODUCTION: Tuberculosis (TB) of the ankle is an uncommon presentation of extrapulmonary infection. The early diagnosis of TB arthritis of the ankle is difficult because of the uncommon site, the ability of TB to mimic other disorders and, all too common, lack of awareness of about this infection in ankle joint. CASE REPORT: A 30-year-old male presented with a 1-year history of right ankle pain and swelling. He denied any history of recent infection but had had recurrent ankle pain that had been treated accordingly...
January 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28630838/a-case-report-of-an-unusual-case-of-tuberculous-osteomyelitis-causing-spontaneous-pathological-fracture-of-humerus-in-a-middle-aged-female
#2
Umesh Birole, Ashish Ranade, Mahesh Mone
INTRODUCTION: Tuberculosis is a major health problem worldwide. Extrapulmonary tuberculosis is often secondary to some primary foci in lungs. There are reports of tuberculous osteomyelitis involving maxilla, ulna, femur, and shoulder joint but none have reported pathological fracture in humeral diaphysis due to tuberculosis osteomyelitis without shoulder joint involvement. We report a case of pathological fracture of humerus diaphysis due to tuberculous osteomyelitis with normal articular space...
January 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28625143/infection-and-malignancy-risk-in-patients-treated-with-tnf-inhibitors-for-immune-mediated-inflammatory-diseases
#3
Rui Pereira, Raquel Faria, Paula Lago, Tiago Torres
BACKGROUND: Infectious and malignant events are responsible for morbidity and mortality in patients with Immune-Mediated Inflammatory Diseases (IMIDs). Anti-tumor necrosis factor (Anti-TNF) agents appear to have an impact, however the individual effect of these agents in the different conditions is still unclear. OBJECTIVE: The goal of this study is to estimate the Incidence Rates (IR) of infections and malignancies in patients treated with anti-TNFs across different IMIDs, as well as potential risk factors...
June 15, 2017: Current Drug Safety
https://www.readbyqxmd.com/read/28625141/bedaquiline-a-new-hope-for-shorter-and-better-anti-tuberculosis-regimens
#4
Niccolò Riccardi, Filippo Del Puente, Federica Magnè, Lucia Taramasso, Antonio Di Biagio
In 2014, an estimated 1.8 million people died from Mycobacterium tuberculosis (MTB); moreover, 680,000 people developed multidrug-resistant TB (MDR-TB). Currently available anti-MDR and XDR regimens are long-lasting and expensive, need high adherence and are undermined by a high frequency of adverse drug events, thus leading to a low success rate; moreover, in the last 50 years only two new molecules, bedaquiline (BDQ) and delamanid, have been approved and released for treatment of MDR-TB. BDQ is a diarylquinoline anti-mycobacterial drug, active regardless the state of MTB; in fact, its efficacy is conserved against replicating and non-replicating bacilli, despite extracellular or intracellular location...
June 19, 2017: Recent Patents on Anti-infective Drug Discovery
https://www.readbyqxmd.com/read/28612695/-peritoneal-tuberculosis
#5
M Koning, L M van der Pol, E F Schippers
Peritoneal tuberculosis was diagnosed in a 38-year-old man from Curaçao, a 42-year-old Dutch man and a 38-year-old woman from Surinam. All patients had been living in the Netherlands for over a decade at the time of diagnosis. Time to diagnosis and treatment varied between patients. Factors contributing to delayed diagnosis were nonspecific symptoms, failure to consider tuberculosis exposure, consulting of more than one physician and delay in obtaining adequate material for histopathologic and microbiologic tests...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28610790/mir-30c-is-specifically-repressed-in-patients-with-active-pulmonary-tuberculosis
#6
Silvana V Spinelli, Rocío Del V Fernández, Luciana Zoff, Bettina Bongiovanni, Ariana Díaz, Luciano D'Attilio, Natalia Santucci, Tomás Alvarez, Marcela M Marchesini, Cristina Bogue, Maria L Bay, Oscar A Bottasso
Tuberculous pleurisy (PLTB) is a common form of extrapulmonary tuberculosis. It often resolves without chemotherapy being hence considered a rather benign manifestation of the disease. Patients with PLTB mount an effective anti-mycobacterial response, unlike those with active pulmonary TB (pTB) that were shown to present an imbalance in plasma immune and endocrine mediators. In this work, we explored whether expression of the active isoform of the glucocorticoid receptor (hGRα) in the context of the inflammatory-anti-inflammatory responses of TB patients may be associated to microRNA levels...
July 2017: Tuberculosis
https://www.readbyqxmd.com/read/28594104/the-risk-factor-of-false-negative-and-false-positive-for-t-spot-tb-in-active-tuberculosis
#7
Li Di, Yan Li
OBJECTIVES: T-SPOT.TB is a promising diagnosis tool to identify both pulmonary tuberculosis and extrapulmonary tuberculosis, as well as latent tuberculosis; however, the factors that affect the results of T-SPOT.TB remains unclear. In this study, we aim to figure out the risk factor of T-SPOT.TB for active TB. METHODS: A total of 349 patients were recruited between January 1st, 2016 and January 22st, 2017 at Renmin Hospital of Wuhan University, including 98 subjects with TB and 251 subjects with non-TB disease, and received T-SPOT...
June 8, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28587415/lymph-node-tuberculosis-mimicking-malignancy-on-18-f-fdg-pet-ct-in-two-patients-a-case-report
#8
Rui-Lin Ding, Hong-Ying Cao, Yue Hu, Chang-Ling Shang, Fang Xie, Zhen-Hua Zhang, Qing-Lian Wen
(18)F-fluorodeoxyglucose positron emission/computed tomography ((18)F-FDG PET/CT) imaging, an established procedure for evaluation of malignancy, reports an increased (18)F-FDG uptake in acute or chronic inflammatory condition. Lymph node tuberculosis (LNTB) is the most common form of extrapulmonary tuberculosis. However, the absence of clinical symptoms and bacteriological basis makes it difficult to diagnose. In the current case report, two patients with LNTB mimicking malignant lymphoma are presented by (18)F-FDG PET/CT...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28583076/diagnostic-accuracy-of-nucleic-acid-amplification-tests-naats-in-urine-for-genitourinary-tuberculosis-a-systematic-review-and-meta-analysis
#9
Carlos Altez-Fernandez, Victor Ortiz, Majid Mirzazadeh, Luis Zegarra, Carlos Seas, Cesar Ugarte-Gil
BACKGROUND: Genitourinary tuberculosis is the third most common form of extrapulmonary tuberculosis. Diagnosis is difficult because of unspecific clinical manifestations and low accuracy of conventional tests. Unfortunately, the delayed diagnosis impacts the urinary tract severely. Nucleic acid amplification tests yield fast results, and among these, new technologies can also detect drug resistance. There is lack of consensus regarding the use of these tests in genitourinary tuberculosis; we therefore aimed to assess the accuracy of nucleic acid amplification tests in the diagnosis of genitourinary tuberculosis and to evaluate the heterogeneity between studies...
June 5, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28575173/health-care-associated-mycobacterium-bovis-bcg-infection-in-cancer-patients-without-prior-bcg-instillation
#10
Y Meije, J Martínez-Montauti, J A Caylà, J Loureiro, L Ortega, M Clemente, X Sanz, M Ricart, M J Santomà, P Coll, M Sierra, M Calsina, M Vaqué, I Ruiz-Camps, C López-Sánchez, M Montes, A Ayestarán, J Carratalà, A Orcau
Background: Bacille Calmette-Guérin (BCG), an attenuated strain of Mycobacterium bovis, is widely used as adjunctive therapy for superficial bladder cancer. Intravesical administration of BCG has been associated with systemic infection. Disseminated infection due to M. bovis is otherwise uncommon. Methods: After identification of three patients with health-care associated BCG infection (HCBCGI) who had never received intravesical BCG administration, an epidemiologic study was performed...
May 29, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28571129/comparative-diagnostic-utility-of-is6110-pcr-assay-in-csf-and-peripheral-blood-samples-of-tuberculous-meningitis-patients-a-pilot-study-from-central-india
#11
Sonali D Manke, Aliabbas A Husain, Hatim F Daginawala, Lokendra K Singh, Rajpal S Kashyap
INTRODUCTION: Tuberculous Meningitis (TBM) is the most severe form of Central Nervous System Tuberculosis (CNS-TB) and constitutes about 6% of all Extrapulmonary TB (EPTB) cases. Most guidelines for the diagnosis and management of TBM agree on the use of simple Cerebrospinal Fluid (CSF) analysis using molecular tools like Polymerase Chain Reaction (PCR). However, the sensitivity of PCR varies while using a CSF sample. In the present study, we have compared the diagnostic utility of PCR assay in both peripheral blood and CSF sample collected from TBM cases...
April 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28566080/-molecular-epidemiology-of-human-mycobacterium-bovis-infection-in-aegean-region-turkey
#12
Cengiz Çavuşoğlu, Fethiye Ferda Yılmaz
Mycobacterium bovis, which has a broader host spectrum as opposed to Mycobacterium tuberculosis that generally causes disease in humans, mainly leads to chronic progressive pulmonary disease in a large number of domestic and wild mammals, particularly cattle. The term "zoonotic tuberculosis (TB)" is used to describe M.bovis infection in humans. "Zoonotic TB" can not be differentiated clinically, radiologically or pathologically from TB caused by M.tuberculosis. The aim of this study was to evaluate the role of M...
April 2017: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/28559518/epidemiology-of-extrapulmonary-and-disseminated-tuberculosis-in-a-tertiary-care-center-in-oman
#13
Zied Gaifer
BACKGROUND: The incidence of extrapulmonary and disseminated tuberculosis (TB) cases is increasing worldwide, and this growth significantly impacts TB-related morbidity and mortality. Little is known about the host risk factors for extrapulmonary and disseminated TB. In this study, we examined those risk factors. MATERIALS AND METHODS: We conducted a retrospective review of all TB cases admitted to Sultan Qaboos University Hospital from 2006 to 2015. We compared extrapulmonary TB (EPTB) cases with pulmonary and disseminated TB cases...
April 2017: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28559513/extrapulmonary-tuberculosis-in-colombian-children-epidemiological-and-clinical-data-in-a-reference-hospital
#14
Eileen Viviana Fonseca Sepulveda, Luisa Fernanda Imbachí Yunda, Kelly Christina Márquez Herrera, German Camacho Moreno
BACKGROUND: The pediatric population is at increased risk of disseminated and extrapulmonary tuberculosis (TB). There is little information on children affected by this entity. The demographic, clinical, and outcome characteristics of the treatment of children with extrapulmonary TB, treated at a national reference institution between January 1, 2008, and December 31, 2016, are described and analyzed in this work. MATERIALS AND METHODS: This was a retrospective observational study...
April 2017: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28551717/total-igm-and-anti-phosphatidylcholine-igm-antibody-secretion-continue-after-clearance-of-mycobacterium-bovis-bacillus-calmette-guerin-pleural-infection
#15
Ciara Ordoñez, Musharaf Tarajia, René Rivera, Dilcia Sambrano, Victoria Batista, Mónica Chávez, Denis Tapia, Patricia L Fernández, Amador Goodridge
The cellular immune response to Mycobacterium tuberculosis infection has been well characterized, while the humoral antibody response remains underexplored. We aimed to examine the total and anti-phospholipid IgM levels in the pleural lavage from mice with Mycobacterium bovis BCG extrapulmonary infection. We found that the levels of total and anti-phosphatidylcholine IgM antibodies remained significantly higher in infected mice as compared to non-infected mice up to day 90 after BCG infection, while the anti-cardiolipin IgM antibody levels decreased with bacteria clearance...
May 27, 2017: Lung
https://www.readbyqxmd.com/read/28549036/the-role-of-molecular-techniques-for-the-detection-of-mycobacterium-tuberculosis-complex-in-paraffin-embedded-biopsies
#16
Zaira Moure, Josep Castellví, Adrián Sánchez-Montalvá, Tomás Pumarola, M Teresa Tórtola
INTRODUCTION: Extrapulmonary tuberculosis (EPTB) is increasingly frequent in developed countries. When it is not clinically suspected, samples are not collected for culture and the only material available is a tissue paraffin block. OBJECTIVE: The aim of this study was to evaluate FluoroType MTB (FT-MTB) and GenoType MTBDRplus methods for the detection of Mycobaterium tuberculosis complex in paraffin-embedded biopsies comparing the results to tuberculosis diagnosis...
May 25, 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/28539036/a-case-of-tuberculous-peritonitis-presenting-as-small-bowel-obstruction
#17
Hae Koo Kim, Sung Eun Kim, Moo In Park, Seun Ja Park, Won Moon, Jae Hyun Kim, Kyoungwon Jung, Yong Jin Nam
The peritoneum is one of the common extrapulmonary sites of tuberculosis infection. Patients with underlying end-stage renal or liver disease are frequently complicated by tuberculous peritonitis; however, the diagnosis of the tuberculous peritonitis is difficult due to its insidious nature, well as its variability in presentation and limitation of available diagnostic tests. Once diagnosed, the preferred treatment is usually antituberculous therapy in uncomplicated cases. However, surgical treatment may also be required for complicated cases, such as small bowel obstruction or perforation...
May 25, 2017: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/28531231/utility-of-th1-cell-immune-responses-for-distinguishing-active-tuberculosis-from-non-active-tuberculosis-a-case-control-study
#18
Lifan Zhang, Xinhe Cheng, Sainan Bian, Yanhua Song, Qiang Li, Mengqiu Gao, Yueqiu Zhang, Xiaochun Shi, Xiaoqing Liu
Currently available Interferon-γ release assay (IGRA) cannot reliably differentiate active TB (ATB) from non-active TB (non-ATB). A study was performed to evaluate the value of Mycobacterium tuberculosis (MTB) specific Th1 cell immune responses which test IFN-γ and IL-2 simultaneous for differentiating ATB from non-ATB. Forty-nine newly diagnosed inpatients with ATB (26 pulmonary TB and 23 extrapulmonary TB) were enrolled as the ATB group. Forty-five volunteers with latent tuberculosis infection (LTBI) and twenty with evidence of previous TB were enrolled during the same period as the non-ATB group...
2017: PloS One
https://www.readbyqxmd.com/read/28530443/association-of-single-nucleotide-polymorphism-in-the-hepcidin-promoter-gene-with-susceptibility-to-extrapulmonary-tuberculosis
#19
Li Liang, Huijuan Liu, Jun Yue, Li-Rong Liu, Min Han, Liu-Lin Luo, Yan-Lin Zhao, Heping Xiao
BACKGROUND: Hepcidin is a 25-amino acid peptide produced by the liver in response to inflammation and iron overload. It is encoded by the hepcidin antimicrobial peptide (HAMP) gene and plays a key role in innate immunity. Previous studies have reported that a -582 A>G polymorphism in the HAMP promoter (HAMP-P) affects hepcidin expression, causing susceptibility to various bacterial and viral pathogens. However, it is not known whether the HAMP-P -582 A>G polymorphism is associated with tuberculosis (TB) susceptibility...
June 2017: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/28526681/adoptive-transfer-of-phosphoantigen-specific-%C3%AE-%C3%AE-t-cell-subset-attenuates-mycobacterium-tuberculosis-infection-in-nonhuman-primates
#20
Arwa Qaqish, Dan Huang, Crystal Y Chen, Zhuoran Zhang, Richard Wang, Shengpu Li, Enzhuoa Yang, Yang Lu, Michelle H Larsen, William R Jacobs, Lixia Qian, James Frencher, Ling Shen, Zheng W Chen
The dominant Vγ2Vδ2 T cell subset recognizes phosphoantigen and exists only in humans and nonhuman primates. Despite the discovery of γδ T cells >30 y ago, a proof-of-concept study has not been done to prove the principle that the Vγ2Vδ2 T cell subset is protective against Mycobacterium tuberculosis and other infections. In this study, we used an adoptive cell-transfer strategy to define the protective role of Vγ2Vδ2 T cells in a primate tuberculosis (TB) model. Vγ2Vδ2 T cells for adoptive transfer displayed central/effector memory and mounted effector functions, including the production of anti-M...
June 15, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
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