Frances M Potjewyd, Joel K Annor-Gyamfi, Jeffrey Aubé, Shaoyou Chu, Ivie L Conlon, Kevin J Frankowski, Shiva K R Guduru, Brian P Hardy, Megan D Hopkins, Chizuru Kinoshita, Dmitri B Kireev, Emily R Mason, Charles T Moerk, Felix Nwogbo, Kenneth H Pearce, Timothy I Richardson, David A Rogers, Disha M Soni, Michael Stashko, Xiaodong Wang, Carrow Wells, Timothy M Willson, Stephen V Frye, Jessica E Young, Alison D Axtman
Introduction: The portfolio of novel targets to treat Alzheimer's disease (AD) has been enriched by the Accelerating Medicines Partnership Program for Alzheimer's Disease (AMP AD) program. Methods: Publicly available resources, such as literature and databases, enabled a data-driven effort to identify existing small molecule modulators for many protein products expressed by the genes nominated by AMP AD and suitable positive control compounds to be included in the set...
2022: Alzheimer's & Dementia: Translational Research & Clinical Interventions