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https://www.readbyqxmd.com/read/28643430/platinum-containing-regimens-for-metastatic-breast-cancer
#1
REVIEW
Sam J Egger, Melina L Willson, Jenna Morgan, Harriet S Walker, Sue Carrick, Davina Ghersi, Nicholas Wilcken
BACKGROUND: Studies have reported high tumour response rates for platinum-containing regimens in the treatment of women with metastatic breast cancer. Most of these studies were conducted prior to the 'intrinsic subtype' era, and did not specifically focus on metastatic triple-negative breast cancers (mTNBCs). OBJECTIVES: To identify and review the evidence from randomised trials comparing platinum-containing chemotherapy regimens with regimens not containing platinum in the management of women with metastatic breast cancer...
June 23, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28600025/creating-a-sustainable-collaborative-consumer-health-application-for-chronic-disease-self-management
#2
Constance M Johnson, Steve McIlwain, Oliver Gray, Bradley Willson, Allison Vorderstrasse
As the prevalence of chronic diseases increase, there is a need for consumer-centric health informatics applications that assist individuals with disease self-management skills. However, due to the cost of development of these applications, there is also a need to build a disease agnostic architecture so that they could be reused for any chronic disease. This paper describes the architecture of a collaborative virtual environment (VE) platform, LIVE©, that was developed to teach self-management skills and provide social support to those individuals with type 2 diabetes...
June 6, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28396209/immunogenicity-and-protective-efficacy-of-virus-like-particles-and-recombinant-fiber-proteins-in-broiler-breeder-vaccination-against-fowl-adenovirus-fadv-8b
#3
Ashish Gupta, Khawaja Ashfaque Ahmed, Lisanework E Ayalew, Shelly Popowich, Shanika Kurukulasuriya, Kalhari Goonewardene, Thushari Gunawardana, Ruwani Karunarathna, Davor Ojkic, Suresh K Tikoo, Philip Willson, Susantha Gomis
Inclusion body hepatitis (IBH) is an economically important diseases in broiler chicken industry. Several serotypes of fowl adenovirus (FAdV) can cause IBH, among them, serotype FAdV-8b is associated with the majority of the IBH cases in Canada. Here, we evaluated FAdV-8b virus-like particles (VLPs) and recombinant FAdV-8b fiber proteins (expressed in E. coli) as potential broiler-breeder vaccines against IBH. For assessing the immunogenicity of vaccines, we investigated both humoral and cellular immunity. The humoral immune response was evaluated by determining total IgY and virus-neutralizing antibody in serum at 14, 28, 35 and 60days post-immunization (dpi)...
May 9, 2017: Vaccine
https://www.readbyqxmd.com/read/28366482/monoclonal-antibodies-for-the-treatment-of-nasal-polyps
#4
REVIEW
Thomas J Willson, Robert M Naclerio, Stella E Lee
Biologics are novel therapeutic medications developed for the targeted therapy for a variety of inflammatory conditions. The biologics currently investigated for the treatment of chronic rhinosinusitis (CRS) with nasal polyps modulate specific inflammatory pathways involved in the pathogenesis of disease. Investigations have focused on the most severe form of the disease, namely, CRS with nasal polyps. It is hoped that specific targeted therapies using these biologics can significantly modulate the immune system, offering both disease control and symptomatic relief...
May 2017: Immunology and Allergy Clinics of North America
https://www.readbyqxmd.com/read/28137490/comparative-effectiveness-of-mepolizumab-and-omalizumab-in-severe-asthma-an-indirect-treatment-comparison
#5
Sarah M Cockle, Gillian Stynes, Necdet B Gunsoy, Daniel Parks, Rafael Alfonso-Cristancho, Jaro Wex, Eric S Bradford, Frank C Albers, Jenny Willson
BACKGROUND: Severe asthma is a heterogeneous disease. Patients with both eosinophilic and allergic asthma phenotypes may be eligible for treatment with mepolizumab and omalizumab. Evidence on the relative effectiveness of these treatments in this 'overlap' population would be informative for clinical and payer decision making. METHODS: A systematic literature review and indirect treatment comparison (Bayesian framework) were performed to assess the comparative effectiveness and tolerability of mepolizumab and omalizumab, as add-ons to standard of care...
February 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28089549/modified-live-infectious-bursal-disease-virus-ibdv-vaccine-delays-infection-of-neonatal-broiler-chickens-with-variant-ibdv-compared-to-turkey-herpesvirus-hvt-ibdv-vectored-vaccine
#6
Shanika Kurukulasuriya, Khawaja Ashfaque Ahmed, Davor Ojkic, Thushari Gunawardana, Kalhari Goonewardene, Ashish Gupta, Betty Chow-Lockerbie, Shelly Popowich, Philip Willson, Suresh K Tikoo, Susantha Gomis
Chickens are commonly processed around 35-45days of age in broiler chicken industry hence; diseases that occur at a young age are of paramount economic importance. Early age infection with infectious bursal disease virus (IBDV) results in long-lasting immunosuppression and profound economic losses. To our knowledge, this is the first study comparing the protection efficacy of modified live (MdLV) IBDV and herpesvirus turkey (HVT)-IBDV vaccines against early age variant IBDV (varIBDV) infection in chicks. Experiments were carried out in IBDV maternal antibody (MtAb) positive chicks (n=330), divided into 6 groups (n=50-60/group), namely Group 1 (saline), Group 2 (saline+varIBDV), Group 3 (HVT-IBDV), Group 4 (HVT-IBDV+varIBDV), Group 5 (MdLV) and Group 6 (MdLV+varIBDV)...
January 12, 2017: Vaccine
https://www.readbyqxmd.com/read/27828898/pediatric-ventilator-associated-infections-the-ventilator-associated-infection-study
#7
Douglas F Willson, Michelle Hoot, Robinder Khemani, Christopher Carrol, Aileen Kirby, Adam Schwarz, Rainer Gedeit, Sholeen T Nett, Simon Erickson, Heidi Flori, Spencer Hays, Mark Hall
OBJECTIVE: Suspected ventilator-associated infection is the most common reason for antibiotics in the PICU. We sought to characterize the clinical variables associated with continuing antibiotics after initial evaluation for suspected ventilator-associated infection and to determine whether clinical variables or antibiotic treatment influenced outcomes. DESIGN: Prospective, observational cohort study conducted in 47 PICUs in the United States, Canada, and Australia...
January 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/27748040/maternal-factors-and-the-risk-of-birth-defects-after-ivf-and-icsi-a-whole-of-population-cohort-study
#8
M J Davies, A R Rumbold, J L Marino, K Willson, L C Giles, M J Whitrow, W Scheil, L J Moran, J G Thompson, M Lane, V M Moore
OBJECTIVE: To assess the contribution of maternal factors to major birth defects after in vitro fertilisation (IVF), intracytoplasmic sperm injection (ICSI), and natural conception. DESIGN: Retrospective cohort study in South Australia for the period January 1986 to December 2002. SETTING: A whole of population study. POPULATION: A census of all IVF and ICSI linked to registries for births, pregnancy terminations, and birth defects (diagnosed before a child's fifth birthday)...
October 17, 2016: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/27733779/a-5-year-study-of-the-incidence-and-economic-impact-of-variant-infectious-bursal-disease-viruses-on-broiler-production-in-saskatchewan-canada
#9
Tara Zachar, Shelly Popowich, Bob Goodhope, Tennille Knezacek, Davor Ojkic, Philip Willson, Khawaja Ashfaque Ahmed, Susantha Gomis
While the prevalence of infectious bursal disease virus (IBDV) on chicken farms in some provinces of Canada has been documented, the economic impact of variant IBDV infection on the broiler chicken industry in Saskatchewan has not. The objectives of this study were to identify the variant strains of IBDV circulating on Saskatchewan chicken farms and evaluate their economic impact on broiler production. Infection due to IBDV was detected in 43% of Saskatchewan chicken farms, with variant strains detected in infected birds closely related predominantly to NC171, 586, and Delaware-E...
October 2016: Canadian Journal of Veterinary Research, Revue Canadienne de Recherche Vétérinaire
https://www.readbyqxmd.com/read/27663370/circulating-strains-of-variant-infectious-bursal-disease-virus-may-pose-a-challenge-for-antibiotic-free-chicken-farming-in-canada
#10
Shanika Kurukulsuriya, Khawaja Ashfaque Ahmed, Davor Ojkic, Thushari Gunawardana, Ashish Gupta, Kalhari Goonewardene, Ruwani Karunaratne, Shelly Popowich, Philip Willson, Suresh K Tikoo, Susantha Gomis
Antibiotic-free and safe animal products are most desirable among consumers. However, ensuring safe poultry products is a challenging task when the chicken immune system is compromised. Infectious bursal disease virus (IBDV) causes immunosuppression and predisposes chickens to secondary infections. Breeder vaccination against IBDV is routinely practiced for producing chicks with maternally-derived antibody (MAb) to prevent infection in newly hatched chicks. The majority of IBDV circulating in Canadian farms are variant strains (vIBDV)...
October 2016: Research in Veterinary Science
https://www.readbyqxmd.com/read/27355525/impact-of-weight-extremes-on-clinical-outcomes-in-pediatric-acute-respiratory-distress-syndrome
#11
MULTICENTER STUDY
Shan L Ward, Virginia Gildengorin, Stacey L Valentine, Anil Sapru, Martha A Q Curley, Neal Thomas, Douglas F Willson, Heidi R Flori
OBJECTIVES: To determine whether weight extremes impact clinical outcomes in pediatric acute respiratory distress syndrome. DESIGN: Post hoc analysis of a cohort created by combining five multicenter pediatric acute respiratory distress syndrome studies. SETTING: Forty-three academic PICUs worldwide. PATIENTS: A total of 711 subjects prospectively diagnosed with pediatric acute respiratory distress syndrome. INTERVENTION: Subjects more than 2 years were included and categorized by Center for Disease Control and Prevention body mass index z score criteria: underweight (< -1...
November 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27083413/persistent-effects-of-libby-amphibole-and-amosite-asbestos-following-subchronic-inhalation-in-rats
#12
Stephen H Gavett, Carl U Parkinson, Gabrielle A Willson, Charles E Wood, Annie M Jarabek, Kay C Roberts, Urmila P Kodavanti, Darol E Dodd
BACKGROUND: Human exposure to Libby amphibole (LA) asbestos increases risk of lung cancer, mesothelioma, and non-malignant respiratory disease. This study evaluated potency and time-course effects of LA and positive control amosite (AM) asbestos fibers in male F344 rats following nose-only inhalation exposure. METHODS: Rats were exposed to air, LA (0.5, 3.5, or 25.0 mg/m(3) targets), or AM (3.5 mg/m(3) target) for 10 days and assessed for markers of lung inflammation, injury, and cell proliferation...
April 15, 2016: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/26513203/research-as-a-standard-of-care-in-the-picu
#13
REVIEW
Jerry J Zimmerman, Kanwaljeet J S Anand, Kathleen L Meert, Douglas F Willson, Christopher J L Newth, Rick Harrison, Joseph A Carcillo, John Berger, Tammara L Jenkins, Carol Nicholson, J Michael Dean
OBJECTIVES: Excellence in clinical care coupled with basic and applied research reflects the maturation of a medical subspecialty, advances that field, and provides objective data for identifying best practices. PICUs are uniquely suited for conducting translational and clinical research. In addition, multiple investigations have reported that a majority of parents are interested in their children's participation in clinical research, even when the research offers no direct benefit to their child...
January 2016: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/26108699/effect-of-environmental-factors-on-internet-searches-related-to-sinusitis
#14
Thomas J Willson, Joshua Lospinoso, Erik K Weitzel, Kevin C McMains
OBJECTIVES/HYPOTHESIS: Sinusitis significantly affects the population of the United States, exacting direct cost and lost productivity. Patients are likely to search the Internet for information related to their health before seeking care by a healthcare professional. Utilizing data generated from these searches may serve as an epidemiologic surrogate. STUDY DESIGN: A retrospective time series analysis was performed. METHODS: Google search trend data from the Dallas-Fort Worth metro region for the years 2012 and 2013 were collected from www...
November 2015: Laryngoscope
https://www.readbyqxmd.com/read/26047691/economic-hardship-in-childhood-and-adult-health-trajectories-an-alternative-approach-to-investigating-life-course-processes
#15
Kim M Shuey, Andrea E Willson
In this study, we advance existing research on health as a life course process by conceptualizing and measuring both childhood disadvantage and health as dynamic processes in order to investigate the relationship between trajectories of early life socioeconomic conditions and trajectories of health in midlife. We utilize a trajectory-based analysis that takes a disaggregated, person-centered approach to understand dynamic trajectories of health as latent variables that reflect the timing, duration and change in health conditions experienced by respondents over a period of 10 years in midlife as a function of stability and change in exposure to economic hardship in early life...
December 2014: Advances in Life Course Research
https://www.readbyqxmd.com/read/25978622/sensitive-detection-of-norovirus-using-phage-nanoparticle-reporters-in-lateral-flow-assay
#16
Anna E V Hagström, Gavin Garvey, Andrew S Paterson, Sagar Dhamane, Meena Adhikari, Mary K Estes, Ulrich Strych, Katerina Kourentzi, Robert L Atmar, Richard C Willson
Noroviruses are recognized worldwide as the principal cause of acute, non-bacterial gastroenteritis, resulting in 19-21 million cases of disease every year in the United States. Noroviruses have a very low infectious dose, a short incubation period, high resistance to traditional disinfection techniques and multiple modes of transmission, making early, point-of-care detection essential for controlling the spread of the disease. The traditional diagnostic tools, electron microscopy, RT-PCR and ELISA require sophisticated and expensive instrumentation, and are considered too laborious and slow to be useful during severe outbreaks...
2015: PloS One
https://www.readbyqxmd.com/read/25896952/analysis-of-osteoporosis-treatment-patterns-with-bisphosphonates-and-outcomes-among-postmenopausal-veterans
#17
J LaFleur, S L DuVall, T Willson, T Ginter, O Patterson, Y Cheng, K Knippenberg, C Haroldsen, R A Adler, J R Curtis, I Agodoa, R E Nelson
PURPOSE: Adherence and persistence with bisphosphonates are frequently poor, and stopping, restarting, or switching bisphosphonates is common. We evaluated bisphosphonate change behaviors (switching, discontinuing, or reinitiating) over time, as well as fractures and costs, among a large, national cohort of postmenopausal veterans. METHODS: Female veterans aged 50+ treated with bisphosphonates during 2003-2011 were identified in Veterans Health Administration (VHA) datasets...
September 2015: Bone
https://www.readbyqxmd.com/read/25657593/the-clinical-epidemiology-of-male-osteoporosis-a-review-of-the-recent-literature
#18
REVIEW
Tina Willson, Scott D Nelson, Jonathan Newbold, Richard E Nelson, Joanne LaFleur
Osteoporosis, a musculoskeletal disease characterized by decreased bone mineral density (BMD) and an increased risk of fragility fractures, is now recognized as an important public health problem in men. Osteoporotic fractures, particularly of the hip, result in significant morbidity and mortality in men and lead to considerable societal costs. Many national and international organizations now address screening and treatment for men in their osteoporosis clinical guidelines. However, male osteoporosis remains largely underdiagnosed and undertreated...
2015: Clinical Epidemiology
https://www.readbyqxmd.com/read/25655195/activated-notch-counteracts-ikaros-tumor-suppression-in-mouse-and-human-t-cell-acute-lymphoblastic-leukemia
#19
M T Witkowski, L Cimmino, Y Hu, T Trimarchi, H Tagoh, M D McKenzie, S A Best, L Tuohey, T A Willson, S L Nutt, M Busslinger, I Aifantis, G K Smyth, R A Dickins
Activating NOTCH1 mutations occur in ~60% of human T-cell acute lymphoblastic leukemias (T-ALLs), and mutations disrupting the transcription factor IKZF1 (IKAROS) occur in ~5% of cases. To investigate the regulatory interplay between these driver genes, we have used a novel transgenic RNA interference mouse model to produce primary T-ALLs driven by reversible Ikaros knockdown. Restoring endogenous Ikaros expression in established T-ALL in vivo acutely represses Notch1 and its oncogenic target genes including Myc, and in multiple primary leukemias causes disease regression...
June 2015: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/25505261/correlating-regional-aeroallergen-effects-on-internet-search-activity
#20
Thomas J Willson, Joshua Lospinoso, Erik Weitzel, Kevin McMains
OBJECTIVE: To investigate the correlation between the change in regional aeroallergen levels and Internet search activity related to allergies. STUDY DESIGN: A retrospective time series analysis using a graphical analytical approach and statistical modeling was used. SETTING: Tertiary academic hospital setting. SUBJECTS AND METHODS: There were no specific enrolled subjects. Data from Google Trends were obtained (google...
February 2015: Otolaryngology—Head and Neck Surgery
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