Read by QxMD icon Read

Willson's disease

M J Davies, A R Rumbold, J L Marino, K Willson, L C Giles, M J Whitrow, W Scheil, L J Moran, J G Thompson, M Lane, V M Moore
OBJECTIVE: To assess the contribution of maternal factors to major birth defects after in vitro fertilisation (IVF), intracytoplasmic sperm injection (ICSI), and natural conception. DESIGN: Retrospective cohort study in South Australia for the period January 1986 to December 2002. SETTING: A whole of population study. POPULATION: A census of all IVF and ICSI linked to registries for births, pregnancy terminations, and birth defects (diagnosed before a child's fifth birthday)...
October 17, 2016: BJOG: An International Journal of Obstetrics and Gynaecology
Tara Zachar, Shelly Popowich, Bob Goodhope, Tennille Knezacek, Davor Ojkic, Philip Willson, Khawaja Ashfaque Ahmed, Susantha Gomis
While the prevalence of infectious bursal disease virus (IBDV) on chicken farms in some provinces of Canada has been documented, the economic impact of variant IBDV infection on the broiler chicken industry in Saskatchewan has not. The objectives of this study were to identify the variant strains of IBDV circulating on Saskatchewan chicken farms and evaluate their economic impact on broiler production. Infection due to IBDV was detected in 43% of Saskatchewan chicken farms, with variant strains detected in infected birds closely related predominantly to NC171, 586, and Delaware-E...
October 2016: Canadian Journal of Veterinary Research, Revue Canadienne de Recherche Vétérinaire
Shanika Kurukulsuriya, Khawaja Ashfaque Ahmed, Davor Ojkic, Thushari Gunawardana, Ashish Gupta, Kalhari Goonewardene, Ruwani Karunaratne, Shelly Popowich, Philip Willson, Suresh K Tikoo, Susantha Gomis
Antibiotic-free and safe animal products are most desirable among consumers. However, ensuring safe poultry products is a challenging task when the chicken immune system is compromised. Infectious bursal disease virus (IBDV) causes immunosuppression and predisposes chickens to secondary infections. Breeder vaccination against IBDV is routinely practiced for producing chicks with maternally-derived antibody (MAb) to prevent infection in newly hatched chicks. The majority of IBDV circulating in Canadian farms are variant strains (vIBDV)...
October 2016: Research in Veterinary Science
Shan L Ward, Virginia Gildengorin, Stacey L Valentine, Anil Sapru, Martha A Q Curley, Neal Thomas, Douglas F Willson, Heidi R Flori
OBJECTIVES: To determine whether weight extremes impact clinical outcomes in pediatric acute respiratory distress syndrome. DESIGN: Post hoc analysis of a cohort created by combining five multicenter pediatric acute respiratory distress syndrome studies. SETTING: Forty-three academic PICUs worldwide. PATIENTS: A total of 711 subjects prospectively diagnosed with pediatric acute respiratory distress syndrome. INTERVENTION: Subjects more than 2 years were included and categorized by Center for Disease Control and Prevention body mass index z score criteria: underweight (< -1...
June 28, 2016: Critical Care Medicine
Stephen H Gavett, Carl U Parkinson, Gabrielle A Willson, Charles E Wood, Annie M Jarabek, Kay C Roberts, Urmila P Kodavanti, Darol E Dodd
BACKGROUND: Human exposure to Libby amphibole (LA) asbestos increases risk of lung cancer, mesothelioma, and non-malignant respiratory disease. This study evaluated potency and time-course effects of LA and positive control amosite (AM) asbestos fibers in male F344 rats following nose-only inhalation exposure. METHODS: Rats were exposed to air, LA (0.5, 3.5, or 25.0 mg/m(3) targets), or AM (3.5 mg/m(3) target) for 10 days and assessed for markers of lung inflammation, injury, and cell proliferation...
2016: Particle and Fibre Toxicology
Jerry J Zimmerman, Kanwaljeet J S Anand, Kathleen L Meert, Douglas F Willson, Christopher J L Newth, Rick Harrison, Joseph A Carcillo, John Berger, Tammara L Jenkins, Carol Nicholson, J Michael Dean
OBJECTIVES: Excellence in clinical care coupled with basic and applied research reflects the maturation of a medical subspecialty, advances that field, and provides objective data for identifying best practices. PICUs are uniquely suited for conducting translational and clinical research. In addition, multiple investigations have reported that a majority of parents are interested in their children's participation in clinical research, even when the research offers no direct benefit to their child...
January 2016: Pediatric Critical Care Medicine
Thomas J Willson, Joshua Lospinoso, Erik K Weitzel, Kevin C McMains
OBJECTIVES/HYPOTHESIS: Sinusitis significantly affects the population of the United States, exacting direct cost and lost productivity. Patients are likely to search the Internet for information related to their health before seeking care by a healthcare professional. Utilizing data generated from these searches may serve as an epidemiologic surrogate. STUDY DESIGN: A retrospective time series analysis was performed. METHODS: Google search trend data from the Dallas-Fort Worth metro region for the years 2012 and 2013 were collected from www...
November 2015: Laryngoscope
Kim M Shuey, Andrea E Willson
In this study, we advance existing research on health as a life course process by conceptualizing and measuring both childhood disadvantage and health as dynamic processes in order to investigate the relationship between trajectories of early life socioeconomic conditions and trajectories of health in midlife. We utilize a trajectory-based analysis that takes a disaggregated, person-centered approach to understand dynamic trajectories of health as latent variables that reflect the timing, duration and change in health conditions experienced by respondents over a period of 10 years in midlife as a function of stability and change in exposure to economic hardship in early life...
December 2014: Advances in Life Course Research
Anna E V Hagström, Gavin Garvey, Andrew S Paterson, Sagar Dhamane, Meena Adhikari, Mary K Estes, Ulrich Strych, Katerina Kourentzi, Robert L Atmar, Richard C Willson
Noroviruses are recognized worldwide as the principal cause of acute, non-bacterial gastroenteritis, resulting in 19-21 million cases of disease every year in the United States. Noroviruses have a very low infectious dose, a short incubation period, high resistance to traditional disinfection techniques and multiple modes of transmission, making early, point-of-care detection essential for controlling the spread of the disease. The traditional diagnostic tools, electron microscopy, RT-PCR and ELISA require sophisticated and expensive instrumentation, and are considered too laborious and slow to be useful during severe outbreaks...
2015: PloS One
J LaFleur, S L DuVall, T Willson, T Ginter, O Patterson, Y Cheng, K Knippenberg, C Haroldsen, R A Adler, J R Curtis, I Agodoa, R E Nelson
PURPOSE: Adherence and persistence with bisphosphonates are frequently poor, and stopping, restarting, or switching bisphosphonates is common. We evaluated bisphosphonate change behaviors (switching, discontinuing, or reinitiating) over time, as well as fractures and costs, among a large, national cohort of postmenopausal veterans. METHODS: Female veterans aged 50+ treated with bisphosphonates during 2003-2011 were identified in Veterans Health Administration (VHA) datasets...
September 2015: Bone
Tina Willson, Scott D Nelson, Jonathan Newbold, Richard E Nelson, Joanne LaFleur
Osteoporosis, a musculoskeletal disease characterized by decreased bone mineral density (BMD) and an increased risk of fragility fractures, is now recognized as an important public health problem in men. Osteoporotic fractures, particularly of the hip, result in significant morbidity and mortality in men and lead to considerable societal costs. Many national and international organizations now address screening and treatment for men in their osteoporosis clinical guidelines. However, male osteoporosis remains largely underdiagnosed and undertreated...
2015: Clinical Epidemiology
M T Witkowski, L Cimmino, Y Hu, T Trimarchi, H Tagoh, M D McKenzie, S A Best, L Tuohey, T A Willson, S L Nutt, M Busslinger, I Aifantis, G K Smyth, R A Dickins
Activating NOTCH1 mutations occur in ~60% of human T-cell acute lymphoblastic leukemias (T-ALLs), and mutations disrupting the transcription factor IKZF1 (IKAROS) occur in ~5% of cases. To investigate the regulatory interplay between these driver genes, we have used a novel transgenic RNA interference mouse model to produce primary T-ALLs driven by reversible Ikaros knockdown. Restoring endogenous Ikaros expression in established T-ALL in vivo acutely represses Notch1 and its oncogenic target genes including Myc, and in multiple primary leukemias causes disease regression...
June 2015: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
Thomas J Willson, Joshua Lospinoso, Erik Weitzel, Kevin McMains
OBJECTIVE: To investigate the correlation between the change in regional aeroallergen levels and Internet search activity related to allergies. STUDY DESIGN: A retrospective time series analysis using a graphical analytical approach and statistical modeling was used. SETTING: Tertiary academic hospital setting. SUBJECTS AND METHODS: There were no specific enrolled subjects. Data from Google Trends were obtained (google...
February 2015: Otolaryngology—Head and Neck Surgery
Morgan C Willson, Jeffrey S Ross
Imaging of the postoperative spine is common, although it remains a difficult task for radiologists. This article presents an overview of common surgical approaches and spinal hardware, and specific complications that may be associated with each procedure. In addition, expected postoperative changes and complications that are common among procedures, with their differential diagnosis and imaging features, are discussed.
May 2014: Neuroimaging Clinics of North America
John M Cullen, Cynthia J Willson, Jonathan D Minch, Carie L Kimbrough, Katrina L Mealey
The etiology of canine gallbladder mucocele (GBM) has not yet been identified. However, several studies have linked GBM in dogs to particular breeds (Shetland Sheepdogs are commonly implicated), concurrent endocrine disease (hyperadrenocorticism and/or hypothyroidism), and a mutation in the canine ABCB4 gene (ABCB4 1583_1584G), particularly in Shetland Sheepdogs. The current study assessed ABCB4 1583_1584G, in a wider sample of dogs with GBM compared with age and breed-matched controls. ABCB4 1583_1584G was identified in 4 of 8 Shetland Sheepdogs and 13 of 28 other breeds with GBM...
April 23, 2014: Journal of Veterinary Diagnostic Investigation
Douglas F Willson, Mark Conaway, Robin Kelly, J Owen Hendley
OBJECTIVES: Ventilator-associated pneumonia is the first or second most commonly diagnosed nosocomial infection in the PICU. Centers for Disease Control diagnostic criteria include clinical signs or symptoms in conjunction with a "positive" tracheal aspirate, defined as more than 10 colony-forming units/mL of bacteria on quantitative culture and/or more than 25 polymorphonuclear neutrophils per low-power field on Gram stain. We hypothesized that tracheal aspirate cultures and Gram stains would not correlate with clinical signs and symptoms and would therefore not distinguish between colonization and infection...
May 2014: Pediatric Critical Care Medicine
Anne L Robertson, Geoffrey R Holmes, Aleksandra N Bojarczuk, Joseph Burgon, Catherine A Loynes, Myriam Chimen, Amy K Sawtell, Bashar Hamza, Joseph Willson, Sarah R Walmsley, Sean R Anderson, Mark C Coles, Stuart N Farrow, Roberto Solari, Simon Jones, Lynne R Prince, Daniel Irimia, G Ed Rainger, Visakan Kadirkamanathan, Moira K B Whyte, Stephen A Renshaw
Diseases of failed inflammation resolution are common and largely incurable. Therapeutic induction of inflammation resolution is an attractive strategy to bring about healing without increasing susceptibility to infection. However, therapeutic targeting of inflammation resolution has been hampered by a lack of understanding of the underlying molecular controls. To address this drug development challenge, we developed an in vivo screen for proresolution therapeutics in a transgenic zebrafish model. Inflammation induced by sterile tissue injury was assessed for accelerated resolution in the presence of a library of known compounds...
February 26, 2014: Science Translational Medicine
Hannah M Atkins, Cynthia J Willson, Marnie Silverstein, Matthew Jorgensen, Edison Floyd, Jay R Kaplan, Susan E Appt
Female vervet monkeys (Chlorocebus aethiops sabaeus) are used as an experimental model for chronic diseases relevant to women's health. However, reproductive senescence (menopause) has not yet been characterized for vervet monkeys. Here we describe the histologic, hormonal, and menstrual markers of reproductive senescence in vervet monkeys from the Wake Forest Vervet Research Colony. Ovaries from monkeys (age, 0 to 27 y) were serially sectioned (5 μm), stained, and photographed. In every 100th section, the numbers of primordial, primary, and secondary follicles were determined, and triplicate measurements were used to calculate mean numbers of follicles per ovary...
February 2014: Comparative Medicine
Thomas J Willson, Conor Grady, Ernest Braxton, Erik Weitzel
BACKGROUND: Intracranial air is a common finding after many neurosurgical procedures and trauma to the head. In patients requiring transport via air to reach a destination there is risk of expansion of the intracranial air and development of neurological complications. Though relatively uncommon after functional endoscopic sinus surgery (FESS), pneumocephalus may be encountered. CASE REPORT: We describe one of our patients in whom intracranial air was introduced during FESS...
January 2014: Aviation, Space, and Environmental Medicine
Andrew Currie, Elizabeth Bradley, Marcus McEwen, Nawar Al-Shabibi, Peter D Willson
Uterine leiomyomas (fibroids) are seen in up to 4% of pregnancies, and most commonly present with pain in pregnancy, which can be due to red degeneration or torsion. Most cases previously have been managed with open resection. We report the case of a 35-y-old primagravida woman, presenting with acute lower abdominal pain at 11 wk gestation. Ultrasound demonstrated an 8-cm fibroid only. She demonstrated features of lower abdominal peritonitis and was scheduled for a diagnostic laparoscopy. At operation, a torsed subserosal fibroid was found...
October 2013: JSLS: Journal of the Society of Laparoendoscopic Surgeons
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"