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https://www.readbyqxmd.com/read/29241309/involvement-of-endothelial-nitric-oxide-synthase-activation-in-midkine-mediated-central-hypotensive-effects
#1
Ching-Huang Lin, Jun-Yen Pan, Jung-Jui Chang, Hsin-Hung Chen, Pei-Wen Cheng, Ching-Jiunn Tseng
The growth factor midkine has been implicated in various biologic and pathologic events. It has been shown that the peripheral influence of midkine on cardiovascular regulation is due to an influence on the renin-angiotensin system. The nucleus tractus solitarii (NTS) is the primary integrative center for cardiovascular control and other autonomic functions in the central nervous system. However, the signaling mechanisms involved in midkine-mediated cardiovascular effects in the NTS remain unclear. In this study, we investigated whether the renin-angiotensin system and/ or N-methyl-D-aspartate (NMDA) receptor-calmodulin-eNOS signaling pathways were both involved in midkine-mediated blood pressure (BP) regulation in the NTS of Wistar-Kyoto rats...
December 15, 2017: Chinese Journal of Physiology
https://www.readbyqxmd.com/read/29233575/midkine-controls-arteriogenesis-by-regulating-the-bioavailability-of-vascular-endothelial-growth-factor-a-and-the-expression-of-nitric-oxide-synthase-1-and-3
#2
Thomas Lautz, Manuel Lasch, Julia Borgolte, Kerstin Troidl, Judith-Irina Pagel, Amelia Caballero-Martinez, Eike Christian Kleinert, Barbara Walzog, Elisabeth Deindl
Midkine is a pleiotropic factor, which is involved in angiogenesis. However, its mode of action in this process is still ill defined. The function of midkine in arteriogenesis, the growth of natural bypasses from pre-existing collateral arteries, compensating for the loss of an occluded artery has never been investigated. Arteriogenesis is an inflammatory process, which relies on the proliferation of endothelial cells and smooth muscle cells. We show that midkine deficiency strikingly interferes with the proliferation of endothelial cells in arteriogenesis, thereby interfering with the process of collateral artery growth...
November 26, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29208250/elevated-serum-midkine-in-patients-with-acute-pancreatitis
#3
Yao Li, Yongda Lu, Jiaqing Shen, Chunfang Xu
BACKGROUND: Midkine (MK) is reported to be involved in the pathogenesis of numerous pathologies, but the expression of MK in acute pancreatitis (AP) has not been well studied and documented. METHODS: In this study, the temporal changes of serum MK were assessed in 97 patients with AP by enzyme-linked immunosorbent assay. RESULTS: The concentration of serum MK increased along with the severity of AP. Serum MK level increased more significantly in patients with organ failure than in those without organ failure...
December 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29176691/midkine-derived-from-cancer-associated-fibroblasts-promotes-cisplatin-resistance-via-up-regulation-of-the-expression-of-lncrna-anril-in-tumour-cells
#4
Dongya Zhang, Liang Ding, Yi Li, Jing Ren, Guoping Shi, Yong Wang, Shuli Zhao, Yanhong Ni, Yayi Hou
Midkine (MK) is a heparin-binding growth factor that promotes carcinogenesis and chemoresistance. The tumour microenvironment (TME) can affect chemotherapy sensitivity. However, the role of stromal-derived MK, especially in cancer-associated fibroblasts (CAFs), is unclear. Here, we confirmed that MK decreased cisplatin-induced cell death in oral squamous cell carcinoma (OSCC) cells, ovarian cancer cells and lung cancer cells. We also isolated primary CAFs (n = 3) from OSCC patients and found that CAFs secreted increased levels of MK, which abrogated cisplatin-induced cell death...
November 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29164967/increased-serum-midkine-levels-in-autism-spectrum-disorder-patients
#5
Erman Esnafoglu, Selma Cırrık
BACKGROUND: Midkine (MK) is a heparin binding growth factor and is involved in neurogenesis, neural development and neuroprotection. Additionally MK may contribute to cancer development and pathogenesis of neurodegenerative disorders and schizophrenia. Considering these effects of midkine, this study researched whether MK is involved in Autism spectrum disorders (ASD) pathogenesis. METHODS: We evaluated serum MK levels of 38 patients with ASD and 32 healthy control group...
November 22, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/29126140/zona-pellucida-binding-protein-2-zpbp2-and-several-proteins-containing-bx7b-motifs-in-human-sperm-may-have-hyaluronic-acid-binding-or-recognition-properties
#6
F Torabi, O A Bogle, J M Estanyol, R Oliva, D Miller
STUDY QUESTION: Are there novel hyaladherins in human sperm? SUMMARY ANSWER: Zona pellucida-binding protein 2 (ZPBP2), containing a Link-like hyaluronic acid (HA)-binding domain, and several other proteins containing BX7B motifs, such as ADAM32 and Midkine, may be novel hyaladherins with HA-binding properties. WHAT IS KNOWN ALREADY: HA-binding proteins (hyaladherins), which can bind HA surrounding the cumulus-oophorus complex, are distinct from hyases such as PH 20 (SPAM1) and are expressed by mature spermatozoa...
December 1, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/29113102/midkine-and-nanog-have-similar-immunohistochemical-expression-patterns-and-contribute-equally-to-an-adverse-prognosis-of-oral-squamous-cell-carcinoma
#7
Hyun-Min Kim, Young-Hoon Kang, June-Ho Byun, Si-Jung Jang, Gyu-Jin Rho, Jong-Sil Lee, Bong-Wook Park
To increase the overall survival rate and obtain a better prognosis for oral squamous cell carcinoma (OSCC) patients, the detection of more effective and reliable tumor prognostic markers is needed. This study is focused on the analysis of correlation between the clinicopathological features of OSCCs and the immunohistochemical (IHC) expression patterns of MIDKINE (MK) and NANOG. Sixty-two primary OSCC patients were selected and their pretreatment biopsy specimens were immunohistochemically analyzed for the MK and NANOG proteins...
November 6, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29093346/the-truncated-isoform-of-the-receptor-tyrosine-kinase-alk-generated-by-alternative-transcription-initiation-alk-ati-induces-chromatin-structural-changes-in-the-nucleus-in-a-kinase-activity-dependent-manner
#8
Yuki Takakura, Noritaka Yamaguchi, Takuya Honda, Mariko Morii, Ryuzaburo Yuki, Yuji Nakayama, Naoto Yamaguchi
Anaplastic lymphoma kinase (ALK) is a receptor-type tyrosine kinase that promotes cell growth upon stimulation with ligands such as midkine and pleiotrophin. Recently, a truncated isoform of ALK was identified in a variety of tumors. This isoform is expressed from a novel ALK transcript initiated from a de novo alternative transcription initiation (ATI) site in ALK intron 19 (referred to as ALK(ATI)). ALK(ATI), which consists of only the intracellular kinase domain, localizes to the nucleus as well as the cytoplasm...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29061398/endogenous-pleiotrophin-and-midkine-regulate-lps-induced-glial-responses
#9
Rosalía Fernández-Calle, Marta Vicente-Rodríguez, Esther Gramage, Carlos de la Torre-Ortiz, Carmen Pérez-García, María P Ramos, Gonzalo Herradón
Pleiotrophin (PTN) and Midkine (MK) are two growth factors that modulate neuroinflammation. PTN overexpression in the brain prevents LPS-induced astrocytosis in mice but potentiates microglial activation. The modest astrocytic response caused by a low dose of LPS (0.5mg/kg) is blocked in the striatum of MK-/- mice whereas microglial response is unaffected. We have now tested the effects of an intermediate dose of LPS (7.5mg/kg) in glial response in PTN-/- and MK-/- mice. We found that LPS-induced astrocytosis is prevented in prefrontal cortex and striatum of both PTN-/- and MK-/- mice...
October 20, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29050213/serum-protein-fingerprinting-by-pea-immunoassay-coupled-with-a-pattern-recognition-algorithms-distinguishes-mgus-and-multiple-myeloma
#10
Petra Schneiderova, Tomas Pika, Petr Gajdos, Regina Fillerova, Pavel Kromer, Milos Kudelka, Jiri Minarik, Tomas Papajik, Vlastimil Scudla, Eva Kriegova
Serum protein fingerprints associated with MGUS and MM and their changes in MM after autologous stem cell transplantation (MM-ASCT, day 100) remain unexplored. Using highly-sensitive Proximity Extension ImmunoAssay on 92 cancer biomarkers (Proseek Multiplex, Olink), enhanced serum levels of Adrenomedullin (ADM, Pcorr= .0004), Growth differentiation factor 15 (GDF15, Pcorr= .003), and soluble Major histocompatibility complex class I-related chain A (sMICA, Pcorr= .023), all prosurvival and chemoprotective factors for myeloma cells, were detected in MM comparing to MGUS...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/28963279/urine-and-serum-midkine-levels-in-an-australian-chronic-kidney-disease-clinic-population-an-observational-study
#11
Victoria K Campbell, Chris M Anstey, Ryan P Gately, Drew C Comeau, Carolyn J Clark, Euan P Noble, Kumar Mahadevan, Peter R Hollett, Andrea J Pollock, Sharron T Hall, Darren R Jones, Dominic Burg, Nicholas A Gray
BACKGROUND AND OBJECTIVES: The cytokine midkine (MK) is pathologically implicated in progressive chronic kidney disease (CKD) and its systemic consequences and has potential as both a biomarker and therapeutic target. To date, there are no published data on MK levels in patients with different stages of CKD. This study aims to quantify MK levels in patients with CKD and to identify any correlation with CKD stage, cause, progression, comorbid disease or prescribed medication. METHODS: In this observational, single-centre study, demographic data were collected, and serum and urine assayed from 197 patients with CKD and 19 healthy volunteers in an outpatient setting...
September 27, 2017: BMJ Open
https://www.readbyqxmd.com/read/28946562/midkine-and-pleiotrophin-concentrations-in-needle-biopsies-of-breast-and-lung-masses
#12
Nicole M Giamanco, Youn Hee Jee, Anton Wellstein, Craig D Shriver, Thomas A Summers, Jeffrey Baron
BACKGROUND/OBJECTIVE: Midkine (MDK) and pleiotrophin (PTN) are two closely related heparin-binding growth factors which are overexpressed in a wide variety of human cancers. We hypothesized that the concentrations of these factors in washout of biopsy needles would be higher in breast and lung cancer than in benign lesions. METHODS: Seventy subjects underwent pre-operative core needle biopsies of 78 breast masses (16 malignancies). In 11 subjects, fine needle aspiration was performed ex vivo on 7 non-small cell lung cancers and 11 normal lung specimens within surgically excised lung tissue...
September 7, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28934730/dihydroartemisinin-and-curcumin-synergistically-induce-apoptosis-in-skov3-cells-via-upregulation-of-mir-124-targeting-midkine
#13
Jiaojiao Zhao, Yuchen Pan, Xiujun Li, Xuefang Zhang, Yaxian Xue, Tingting Wang, Shuli Zhao, Yayi Hou
BACKGROUND/AIM: Women with advanced ovarian carcinoma are less likely to receive platinum-based chemotherapy and surgery due to a greater risk of cytotoxicity and poorer outcomes. We attempted to improve a promising therapy against ovarian cancer by using a combination of dihydroartemisinin (DHA) and curcumin (Cur). METHODS: Human ovarian cancer SKOV3 cells were treated with DHA, Cur alone, or a combination of both. The viability of SKOV3 cells was measured by Cell Counting Kit-8 (CCK-8) and a colony formation assay...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28920060/midkine-s-role-in-cardiac-pathology
#14
Kathleen C Woulfe, Carmen C Sucharov
Midkine (MDK) is a heparin-binding growth factor that is normally expressed in mid-gestational development mediating mesenchymal and epithelial interactions. As organisms age, expression of MDK diminishes; however, in adults, MDK expression is associated with acute and chronic pathologic conditions such as myocardial infarction and heart failure (HF). The role of MDK is not clear in cardiovascular disease and currently there is no consensus if it plays a beneficial or detrimental role in HF. The lack of clarity in the literature is exacerbated by differing roles that circulating and myocardial MDK play in signaling pathways in cardiomyocytes (some of which have yet to be elucidated)...
September 2017: Journal of Cardiovascular Development and Disease
https://www.readbyqxmd.com/read/28918838/inhibition-of-midkine-suppresses-prostate-cancer-cd133-stem-cell-growth-and-migration
#15
Suat Erdogan, Zeynep B Doganlar, Oguzhan Doganlar, Kader Turkekul, Riza Serttas
BACKGROUND: Midkine (MDK) is a tumor-promoting factor that is often overexpressed in various human carcinomas, and the role of MDK has not yet been fully investigated in prostate cancer stem cells. MATERIALS AND METHODS: Prostate cancer CD133(+) stem cells (PCSCs) were isolated from human castration-resistant PC3 cells. PCSCs were treated with different concentrations of MDK inhibitor, iMDK, for 24-72 hours. The IC50 values were determined by the MTT test. Endogenous MDK messenger RNA expression was knocked down by small interfering RNA...
September 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28915956/dual-inhibition-of-p-glycoprotein-and-midkine-may-increase-therapeutic-effects-of-anticancer-drugs
#16
A Şükrü Aynacıoğlu, Ayhan Bilir, Kenji Kadomatsu
Multidrug resistance (MDR) to chemotherapy may significantly affect the outcome of cancer treatment. ATP-dependent drug efflux pumps, including P-glycoprotein (P-gp), contribute to the resistance of various chemotherapeutic agents. Overexpression of P-gp in tumor cells induces chemoresistance via pumping the anticancer drugs out of the cells. In addition to taking part in many biological processes such as development, reproduction and repair, midkine (MK) also plays important roles in the pathogenesis of malignant diseases as well as in the regulation of MDR...
September 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28874135/cytotoxicity-of-replication-competent-adenoviruses-powered-by-an-exogenous-regulatory-region-is-not-linearly-correlated-with-the-viral-infectivity-gene-expression-or-with-the-e1a-activating-ability-but-is-associated-with-the-p53-genotypes
#17
Suguru Yamauchi, Boya Zhong, Kiyoko Kawamura, Shan Yang, Shuji Kubo, Masato Shingyoji, Ikuo Sekine, Yuji Tada, Koichiro Tatsumi, Hideaki Shimada, Kenzo Hiroshima, Masatoshi Tagawa
BACKGROUND: Replication-competent adenoviruses (Ad) produced cytotoxic effects on infected tumors and have been examined for the clinical applicability. A biomarkers to predict the cytotoxicity is valuable in a clinical setting. METHODS: We constructed type 5 Ad (Ad5) of which the expression of E1A gene was activated by a 5' regulatory sequences of survivin, midkine or cyclooxygenase-2, which were highly expressed in human tumors. We also produced the same replication-competent Ad of which the fiber-knob region was replaced by that of Ad35 (AdF35)...
September 5, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28811360/involvement-of-midkine-in-the-development-of-pulmonary-fibrosis
#18
Kenichi Misa, Yoshinori Tanino, Xintao Wang, Takefumi Nikaido, Masami Kikuchi, Yuki Sato, Ryuichi Togawa, Mishie Tanino, Shinya Tanaka, Kenji Kadomatsu, Mitsuru Munakata
Midkine is a low-molecular-weight heparin-binding protein that is strongly expressed mainly in the midgestation period and has various physiological activities such as in development and cell migration. Midkine has been reported to be strongly expressed in cancer cells and in inflammation and repair processes, and to be involved in the pathogenesis of various diseases. However, its role in the lung is poorly understood. In this study, we analyzed the clinical characteristics of idiopathic pulmonary fibrosis patients in relation to midkine expression and used a mouse bleomycin-induced pulmonary fibrosis model to investigate the role of midkine in pulmonary fibrosis...
August 2017: Physiological Reports
https://www.readbyqxmd.com/read/28694783/mpa-modulates-tight-junctions-permeability-via-midkine-pi3k-pathway-in-caco-2-cells-a-possible-mechanism-of-leak-flux-diarrhea-in-organ-transplanted-patients
#19
Niamat Khan, Lutz Binder, D V Krishna Pantakani, Abdul R Asif
Mycophenolic acid (MPA) is prescribed to prevent allograft rejection in organ transplanted patients. However, its use is sporadically linked to leak flux diarrhea and other gastrointestinal (GI) disturbances in around 75% of patients through yet unknown mechanisms. Recently, we identified Midkine as a modulator of tight junctions (TJs) permeability in MPA treated Caco-2 monolayer. In the present study, we investigated the possible involvement of Midkine dependent PI3K pathway in alteration of TJs under MPA treatment...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28687568/a-lymphoreporter-mouse-model-identifies-midkine-as-a-metastasis-driver
#20
(no author information available yet)
Midkine systemically induces neo-lymphangiogenesis via mTOR signaling in patients with melanoma.
August 2017: Cancer Discovery
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