keyword
MENU ▼
Read by QxMD icon Read
search

midkine

keyword
https://www.readbyqxmd.com/read/29126140/zona-pellucida-binding-protein-2-zpbp2-and-several-proteins-containing-bx7b-motifs-in-human-sperm-may-have-hyaluronic-acid-binding-or-recognition-properties
#1
F Torabi, O A Bogle, J M Estanyol, R Oliva, D Miller
STUDY QUESTION: Are there novel hyaladherins in human sperm? SUMMARY ANSWER: Zona pellucida-binding protein 2 (ZPBP2), containing a Link-like hyaluronic acid (HA)-binding domain, and several other proteins containing BX7B motifs, such as ADAM32 and Midkine, may be novel hyaladherins with HA-binding properties. WHAT IS KNOWN ALREADY: HA-binding proteins (hyaladherins), which can bind HA surrounding the cumulus-oophorus complex, are distinct from hyases such as PH 20 (SPAM1) and are expressed by mature spermatozoa...
November 8, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/29113102/midkine-and-nanog-have-similar-immunohistochemical-expression-patterns-and-contribute-equally-to-an-adverse-prognosis-of-oral-squamous-cell-carcinoma
#2
Hyun-Min Kim, Young-Hoon Kang, June-Ho Byun, Si-Jung Jang, Gyu-Jin Rho, Jong-Sil Lee, Bong-Wook Park
To increase the overall survival rate and obtain a better prognosis for oral squamous cell carcinoma (OSCC) patients, the detection of more effective and reliable tumor prognostic markers is needed. This study is focused on the analysis of correlation between the clinicopathological features of OSCCs and the immunohistochemical (IHC) expression patterns of MIDKINE (MK) and NANOG. Sixty-two primary OSCC patients were selected and their pretreatment biopsy specimens were immunohistochemically analyzed for the MK and NANOG proteins...
November 6, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29093346/the-truncated-isoform-of-the-receptor-tyrosine-kinase-alk-generated-by-alternative-transcription-initiation-alk-ati-induces-chromatin-structural-changes-in-the-nucleus-in-a-kinase-activity-dependent-manner
#3
Yuki Takakura, Noritaka Yamaguchi, Takuya Honda, Mariko Morii, Ryuzaburo Yuki, Yuji Nakayama, Naoto Yamaguchi
Anaplastic lymphoma kinase (ALK) is a receptor-type tyrosine kinase that promotes cell growth upon stimulation with ligands such as midkine and pleiotrophin. Recently, a truncated isoform of ALK was identified in a variety of tumors. This isoform is expressed from a novel ALK transcript initiated from a de novo alternative transcription initiation (ATI) site in ALK intron 19 (referred to as ALK(ATI)). ALK(ATI), which consists of only the intracellular kinase domain, localizes to the nucleus as well as the cytoplasm...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29061398/endogenous-pleiotrophin-and-midkine-regulate-lps-induced-glial-responses
#4
Rosalía Fernández-Calle, Marta Vicente-Rodríguez, Esther Gramage, Carlos de la Torre-Ortiz, Carmen Pérez-García, María P Ramos, Gonzalo Herradón
Pleiotrophin (PTN) and Midkine (MK) are two growth factors that modulate neuroinflammation. PTN overexpression in the brain prevents LPS-induced astrocytosis in mice but potentiates microglial activation. The modest astrocytic response caused by a low dose of LPS (0.5mg/kg) is blocked in the striatum of MK-/- mice whereas microglial response is unaffected. We have now tested the effects of an intermediate dose of LPS (7.5mg/kg) in glial response in PTN-/- and MK-/- mice. We found that LPS-induced astrocytosis is prevented in prefrontal cortex and striatum of both PTN-/- and MK-/- mice...
October 20, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29050213/serum-protein-fingerprinting-by-pea-immunoassay-coupled-with-a-pattern-recognition-algorithms-distinguishes-mgus-and-multiple-myeloma
#5
Petra Schneiderova, Tomas Pika, Petr Gajdos, Regina Fillerova, Pavel Kromer, Milos Kudelka, Jiri Minarik, Tomas Papajik, Vlastimil Scudla, Eva Kriegova
Serum protein fingerprints associated with MGUS and MM and their changes in MM after autologous stem cell transplantation (MM-ASCT, day 100) remain unexplored. Using highly-sensitive Proximity Extension ImmunoAssay on 92 cancer biomarkers (Proseek Multiplex, Olink), enhanced serum levels of Adrenomedullin (ADM, Pcorr= .0004), Growth differentiation factor 15 (GDF15, Pcorr= .003), and soluble Major histocompatibility complex class I-related chain A (sMICA, Pcorr= .023), all prosurvival and chemoprotective factors for myeloma cells, were detected in MM comparing to MGUS...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/28963279/urine-and-serum-midkine-levels-in-an-australian-chronic-kidney-disease-clinic-population-an-observational-study
#6
Victoria K Campbell, Chris M Anstey, Ryan P Gately, Drew C Comeau, Carolyn J Clark, Euan P Noble, Kumar Mahadevan, Peter R Hollett, Andrea J Pollock, Sharron T Hall, Darren R Jones, Dominic Burg, Nicholas A Gray
BACKGROUND AND OBJECTIVES: The cytokine midkine (MK) is pathologically implicated in progressive chronic kidney disease (CKD) and its systemic consequences and has potential as both a biomarker and therapeutic target. To date, there are no published data on MK levels in patients with different stages of CKD. This study aims to quantify MK levels in patients with CKD and to identify any correlation with CKD stage, cause, progression, comorbid disease or prescribed medication. METHODS: In this observational, single-centre study, demographic data were collected, and serum and urine assayed from 197 patients with CKD and 19 healthy volunteers in an outpatient setting...
September 27, 2017: BMJ Open
https://www.readbyqxmd.com/read/28946562/midkine-and-pleiotrophin-concentrations-in-needle-biopsies-of-breast-and-lung-masses
#7
Nicole M Giamanco, Youn Hee Jee, Anton Wellstein, Craig D Shriver, Thomas A Summers, Jeffrey Baron
BACKGROUND/OBJECTIVE: Midkine (MDK) and pleiotrophin (PTN) are two closely related heparin-binding growth factors which are overexpressed in a wide variety of human cancers. We hypothesized that the concentrations of these factors in washout of biopsy needles would be higher in breast and lung cancer than in benign lesions. METHODS: Seventy subjects underwent pre-operative core needle biopsies of 78 breast masses (16 malignancies). In 11 subjects, fine needle aspiration was performed ex vivo on 7 non-small cell lung cancers and 11 normal lung specimens within surgically excised lung tissue...
September 7, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28934730/dihydroartemisinin-and-curcumin-synergistically-induce-apoptosis-in-skov3-cells-via-upregulation-of-mir-124-targeting-midkine
#8
Jiaojiao Zhao, Yuchen Pan, Xiujun Li, Xuefang Zhang, Yaxian Xue, Tingting Wang, Shuli Zhao, Yayi Hou
BACKGROUND/AIM: Women with advanced ovarian carcinoma are less likely to receive platinum-based chemotherapy and surgery due to a greater risk of cytotoxicity and poorer outcomes. We attempted to improve a promising therapy against ovarian cancer by using a combination of dihydroartemisinin (DHA) and curcumin (Cur). METHODS: Human ovarian cancer SKOV3 cells were treated with DHA, Cur alone, or a combination of both. The viability of SKOV3 cells was measured by Cell Counting Kit-8 (CCK-8) and a colony formation assay...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28920060/midkine-s-role-in-cardiac-pathology
#9
Kathleen C Woulfe, Carmen C Sucharov
Midkine (MDK) is a heparin-binding growth factor that is normally expressed in mid-gestational development mediating mesenchymal and epithelial interactions. As organisms age, expression of MDK diminishes; however, in adults, MDK expression is associated with acute and chronic pathologic conditions such as myocardial infarction and heart failure (HF). The role of MDK is not clear in cardiovascular disease and currently there is no consensus if it plays a beneficial or detrimental role in HF. The lack of clarity in the literature is exacerbated by differing roles that circulating and myocardial MDK play in signaling pathways in cardiomyocytes (some of which have yet to be elucidated)...
September 2017: Journal of Cardiovascular Development and Disease
https://www.readbyqxmd.com/read/28918838/inhibition-of-midkine-suppresses-prostate-cancer-cd133-stem-cell-growth-and-migration
#10
Suat Erdogan, Zeynep B Doganlar, Oguzhan Doganlar, Kader Turkekul, Riza Serttas
BACKGROUND: Midkine (MDK) is a tumor-promoting factor that is often overexpressed in various human carcinomas, and the role of MDK has not yet been fully investigated in prostate cancer stem cells. MATERIALS AND METHODS: Prostate cancer CD133(+) stem cells (PCSCs) were isolated from human castration-resistant PC3 cells. PCSCs were treated with different concentrations of MDK inhibitor, iMDK, for 24-72 hours. The IC50 values were determined by the MTT test. Endogenous MDK messenger RNA expression was knocked down by small interfering RNA...
September 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28915956/dual-inhibition-of-p-glycoprotein-and-midkine-may-increase-therapeutic-effects-of-anticancer-drugs
#11
A Şükrü Aynacıoğlu, Ayhan Bilir, Kenji Kadomatsu
Multidrug resistance (MDR) to chemotherapy may significantly affect the outcome of cancer treatment. ATP-dependent drug efflux pumps, including P-glycoprotein (P-gp), contribute to the resistance of various chemotherapeutic agents. Overexpression of P-gp in tumor cells induces chemoresistance via pumping the anticancer drugs out of the cells. In addition to taking part in many biological processes such as development, reproduction and repair, midkine (MK) also plays important roles in the pathogenesis of malignant diseases as well as in the regulation of MDR...
September 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28874135/cytotoxicity-of-replication-competent-adenoviruses-powered-by-an-exogenous-regulatory-region-is-not-linearly-correlated-with-the-viral-infectivity-gene-expression-or-with-the-e1a-activating-ability-but-is-associated-with-the-p53-genotypes
#12
Suguru Yamauchi, Boya Zhong, Kiyoko Kawamura, Shan Yang, Shuji Kubo, Masato Shingyoji, Ikuo Sekine, Yuji Tada, Koichiro Tatsumi, Hideaki Shimada, Kenzo Hiroshima, Masatoshi Tagawa
BACKGROUND: Replication-competent adenoviruses (Ad) produced cytotoxic effects on infected tumors and have been examined for the clinical applicability. A biomarkers to predict the cytotoxicity is valuable in a clinical setting. METHODS: We constructed type 5 Ad (Ad5) of which the expression of E1A gene was activated by a 5' regulatory sequences of survivin, midkine or cyclooxygenase-2, which were highly expressed in human tumors. We also produced the same replication-competent Ad of which the fiber-knob region was replaced by that of Ad35 (AdF35)...
September 5, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28811360/involvement-of-midkine-in-the-development-of-pulmonary-fibrosis
#13
Kenichi Misa, Yoshinori Tanino, Xintao Wang, Takefumi Nikaido, Masami Kikuchi, Yuki Sato, Ryuichi Togawa, Mishie Tanino, Shinya Tanaka, Kenji Kadomatsu, Mitsuru Munakata
Midkine is a low-molecular-weight heparin-binding protein that is strongly expressed mainly in the midgestation period and has various physiological activities such as in development and cell migration. Midkine has been reported to be strongly expressed in cancer cells and in inflammation and repair processes, and to be involved in the pathogenesis of various diseases. However, its role in the lung is poorly understood. In this study, we analyzed the clinical characteristics of idiopathic pulmonary fibrosis patients in relation to midkine expression and used a mouse bleomycin-induced pulmonary fibrosis model to investigate the role of midkine in pulmonary fibrosis...
August 2017: Physiological Reports
https://www.readbyqxmd.com/read/28694783/mpa-modulates-tight-junctions-permeability-via-midkine-pi3k-pathway-in-caco-2-cells-a-possible-mechanism-of-leak-flux-diarrhea-in-organ-transplanted-patients
#14
Niamat Khan, Lutz Binder, D V Krishna Pantakani, Abdul R Asif
Mycophenolic acid (MPA) is prescribed to prevent allograft rejection in organ transplanted patients. However, its use is sporadically linked to leak flux diarrhea and other gastrointestinal (GI) disturbances in around 75% of patients through yet unknown mechanisms. Recently, we identified Midkine as a modulator of tight junctions (TJs) permeability in MPA treated Caco-2 monolayer. In the present study, we investigated the possible involvement of Midkine dependent PI3K pathway in alteration of TJs under MPA treatment...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28687568/a-lymphoreporter-mouse-model-identifies-midkine-as-a-metastasis-driver
#15
(no author information available yet)
Midkine systemically induces neo-lymphangiogenesis via mTOR signaling in patients with melanoma.
August 2017: Cancer Discovery
https://www.readbyqxmd.com/read/28686647/diagnostic-accuracy-of-elisa-for-detecting-serum-midkine-in-cancer-patients
#16
Xuan Jing, Xiangrong Cui, Hongping Liang, Chonghua Hao, Chongyang Han
Midkine (MK) has been reported as the potential novel diagnostic biomarker for cancer in several studies, but their results were controversial. Therefore, we performed a diagnostic meta-analysis to assess the diagnostic value of serum MK in cancer patients. A systematic electronic and manual search was performed for relevant literatures through several databases up to June 1, 2017. The quality of the studies included in the meta-analysis was assessed using the Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) tool...
2017: PloS One
https://www.readbyqxmd.com/read/28683813/the-inflammatory-phase-of-fracture-healing-is-influenced-by-oestrogen-status-in-mice
#17
Melanie Haffner-Luntzer, Verena Fischer, Katja Prystaz, Astrid Liedert, Anita Ignatius
BACKGROUND: Fracture healing is known to be delayed in postmenopausal, osteoporotic females under oestrogen-deficient conditions. Confirming this, experimental studies demonstrated impaired callus formation in ovariectomised animals. Oestrogen-deficiency is known to affect the immune system and the inflammatory response during wound healing. Because a balanced immune response is required for proper bone healing, we were interested to ascertain whether the early immune response after facture is affected by oestrogen depletion...
July 6, 2017: European Journal of Medical Research
https://www.readbyqxmd.com/read/28658220/whole-body-imaging-of-lymphovascular-niches-identifies-pre-metastatic-roles-of-midkine
#18
David Olmeda, Daniela Cerezo-Wallis, Erica Riveiro-Falkenbach, Paula C Pennacchi, Marta Contreras-Alcalde, Nuria Ibarz, Metehan Cifdaloz, Xavier Catena, Tonantzin G Calvo, Estela Cañón, Direna Alonso-Curbelo, Javier Suarez, Lisa Osterloh, Osvaldo Graña, Francisca Mulero, Diego Megías, Marta Cañamero, Jorge L Martínez-Torrecuadrada, Chandrani Mondal, Julie Di Martino, David Lora, Inés Martinez-Corral, J Javier Bravo-Cordero, Javier Muñoz, Susana Puig, Pablo Ortiz-Romero, José L Rodriguez-Peralto, Sagrario Ortega, María S Soengas
Cutaneous melanoma is a type of cancer with an inherent potential for lymph node colonization, which is generally preceded by neolymphangiogenesis. However, sentinel lymph node removal does not necessarily extend the overall survival of patients with melanoma. Moreover, lymphatic vessels collapse and become dysfunctional as melanomas progress. Therefore, it is unclear whether (and how) lymphangiogenesis contributes to visceral metastasis. Soluble and vesicle-associated proteins secreted by tumours and/or their stroma have been proposed to condition pre-metastatic sites in patients with melanoma...
June 28, 2017: Nature
https://www.readbyqxmd.com/read/28656262/suppression-of-midkine-gene-promotes-the-antitumoral-effect-of-cisplatin-on-human-gastric-cancer-cell-line-ags-in-vitro-and-in-vivo-via-the-modulation-of-notch-signaling-pathway
#19
Wenyan Tian, Jiaqing Shen, Weichang Chen
Midkine (MK) is reported to be associated with the clinical stages and distant metastases in gastric cancer, and to positively regulate the proliferation of human gastric cancer cells. However, the possible mechanisms of MK in the development of gastric cancer are still not fully clarified. In this study, the therapeutic effect of MK inhibition in gastric cancer in vivo and in vitro was investigated, by knock-down of MK expression with a small interfering RNA (siRNA). MK was expressed in gastric carcinoma tissues and cancer cells...
August 2017: Oncology Reports
https://www.readbyqxmd.com/read/28621483/glycodendrimers-as-chondroitin-sulfate-mimetics-synthesis-and-binding-to-growth-factor-midkine
#20
Pedro Domínguez-Rodríguez, José J Reina, Sergio Gil-Caballero, Pedro M Nieto, José L de Paz, Javier Rojo
Chondroitin sulfate (CS) is a member of the glycosaminoglycan (GAG) family, a class of polysaccharides implicated in relevant biological functions. The structural complexity of these carbohydrates demands the development of simple glycomimetics as useful tools to study the biological processes in which GAGs are involved. In this work we described the synthesis of the disaccharide unit of the CS-E (GlcA-GalNAc(4,6-di-OSO3 )), in a multivalent presentation. Using a fluorescence polarization competition assay we have demonstrated that a hexavalent dendrimer of this disaccharide interact with midkine, in the low micromolar range...
August 22, 2017: Chemistry: a European Journal
keyword
keyword
75554
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"