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Folate deficiency and cardiovascular disease

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https://www.readbyqxmd.com/read/27876556/homocysteine-and-disease-causal-associations-or-epiphenomenons
#1
REVIEW
Luciana Hannibal, Henk J Blom
Nutritional and genetic deficiencies of folate and vitamin B12 lead to elevation of cellular homocysteine (Hcy), which translates in increased plasma Hcy. The sources and role of elevated plasma Hcy in pathology continues to be a subject of intense scientific debate. Whether a cause, mediator or marker, little is known about the molecular mechanisms and interactions of Hcy with cellular processes that lead to disease. The use of folic acid reduces the incidence of neural tube defects, but the effect of Hcy-lowering interventions with folic acid in cardiovascular disease and cognitive impairment remains controversial...
November 19, 2016: Molecular Aspects of Medicine
https://www.readbyqxmd.com/read/27864850/hyperhomocysteinemia-in-greyhounds-and-its-association-with-hypofolatemia-and-other-clinicopathologic-variables
#2
R M Heilmann, N Grützner, M C Iazbik, R Lopes, C S Bridges, J S Suchodolski, C G Couto, J M Steiner
BACKGROUND: Folate and cobalamin are essential cofactors for homocysteine (HCY) metabolism. Hyperhomocysteinemia, a multifactorial condition, may reflect B vitamin deficiency and is associated with increased risk of cardiovascular disease, thrombosis, and neurodegenerative and chronic gastrointestinal diseases in humans. Hyperhomocysteinemia has been reported in Greyhounds with suspected chronic enteropathy. OBJECTIVES: To evaluate the frequencies of and the association between hypofolatemia and hyperhomocysteinemia in Greyhounds...
November 19, 2016: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/27854316/causes-consequences-and-public-health-implications-of-low-b-vitamin-status-in-ageing
#3
REVIEW
Kirsty Porter, Leane Hoey, Catherine F Hughes, Mary Ward, Helene McNulty
The potential protective roles of folate and the metabolically related B-vitamins (vitamins B12, B6 and riboflavin) in diseases of ageing are of increasing research interest. The most common cause of folate and riboflavin deficiencies in older people is low dietary intake, whereas low B12 status is primarily associated with food-bound malabsorption, while sub-optimal vitamin B6 status is attributed to increased requirements in ageing. Observational evidence links low status of folate and the related B-vitamins (and/or elevated concentrations of homocysteine) with a higher risk of degenerative diseases including cardiovascular disease (CVD), cognitive dysfunction and osteoporosis...
November 16, 2016: Nutrients
https://www.readbyqxmd.com/read/27649570/heterogenous-distribution-of-mthfr-gene-variants-among-mestizos-and-diverse-amerindian-groups-from-mexico
#4
Cecilia Contreras-Cubas, Beatríz E Sánchez-Hernández, Humberto García-Ortiz, Angélica Martínez-Hernández, Francisco Barajas-Olmos, Miguel Cid, Elvia C Mendoza-Caamal, Federico Centeno-Cruz, Gabriela Ortiz-Cruz, José Concepción Jiménez-López, Emilio J Córdova, Eva Gabriela Salas-Bautista, Yolanda Saldaña-Alvarez, Juan Carlos Fernández-López, Osvaldo M Mutchinick, Lorena Orozco
Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in folate metabolism. Folate deficiency has been related to several conditions, including neural tube defects (NTDs) and cardiovascular diseases. Hence, MTHFR genetic variants have been studied worldwide, particularly the C677T and A1298C. We genotyped the C677T and A1298C MTHFR polymorphisms in Mexican Amerindians (MAs), from the largest sample included in a genetic study (n = 2026, from 62 ethnic groups), and in a geographically-matched Mexican Mestizo population (MEZ, n = 638)...
2016: PloS One
https://www.readbyqxmd.com/read/27342231/an-overview-of-compounds-derived-from-the-shikimate-and-phenylpropanoid-pathways-and-their-medicinal-importance
#5
Takayuki Tohge, Alisdair R Fernie
There has been a massive increase in the number of reports about the medicinal benefits of the consumption of phenylpropanoids derived from the plastidic shikimate pathway. These benefits include anti-retroviral, anti-hypertensive, anti-inflammatory, anti-aging and insulin-sensitizing activities, the reduction of the risk of a range of chronic diseases including cardiovascular disease, cancer and osteoporosis as well as inhibition of LDL (low-density lipoprotein) oxidation. In addition, chorismate-derived salicylate which was originally isolated from plants, albeit now under chemical production, is massively used for pain relief in the form of acetylsalycilic acid, namely aspirin...
June 24, 2016: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/27323339/serum-folate-concentrations-and-all-cause-cardiovascular-disease-and-cancer-mortality-a-cohort-study-based-on-1999-2010-national-health-and-nutrition-examination-survey-nhanes
#6
Yang Peng, Bin Dong, Zhiqiang Wang
BACKGROUND: The relationships between serum folate levels and all-cause, cardiovascular disease (CVD), and cancer mortality are controversial. METHODS: Utilizing 1999-2010 National Health and Nutrition Examination Survey (NHANES) and linked mortality data, we performed a cohort study with 28,845 participants and used Cox proportional hazards models and restricted cubic spline plots to elucidate the dose-response relationships between serum folate status and all-cause, CVD and cancer mortality...
September 15, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27273348/hyperhomocysteinemia-is-associated-with-vitamin-b-12-deficiency-a-cross-sectional-study-in-a-rural-elderly-population-of-shanxi-china
#7
J Zhang, T-T Liu, W Zhang, Y Li, X-Y Niu, Y-L Fang, L-S Ma, C-X Li
OBJECTIVES: To report the association of lifestyle factors and plasma vitamin B-12 with hyperhomocysteinemia in a large sample of men and women living in a region of China where there is an increased risk of NTDs. DESIGN: Community-based, cross-sectional study of Lvliang City, Shanxi Province, China. SETTING: Hyperhomocysteinemia is an independent risk factor for cardiovascular disease (CVD) and a sensitive marker of vitamin B-12 and folate deficiency...
2016: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/27178438/genetic-animal-models-to-decipher-the-pathogenic-effects-of-vitamin-b12-and-folate-deficiency
#8
REVIEW
Lu Peng, Natacha Dreumont, David Coelho, Jean-Louis Guéant, Carole Arnold
Vitamin B12 and folate are essential micronutrients that provide methyl groups for cellular methylations through the so-called one-carbon metabolism. Deficits in the absorption and transport or defects of the enzymes can lead to human pathogenesis comprising hematologic, neural, gastrointestinal, hepatic, renal, cardiovascular and developmental manifestations. One-carbon metabolism is a complex, multistep and multi-organ metabolism, and the understanding of the mechanisms at work have benefited from human inborn errors and population studies, as well as from nutritional animal models...
July 2016: Biochimie
https://www.readbyqxmd.com/read/27130656/mthfr-addressing-genetic-counseling-dilemmas-using-evidence-based-literature
#9
REVIEW
Brooke Levenseller Levin, Elizabeth Varga
The 5, 10 methylenetetrahydrofolate reductase (MTHFR) enzyme is a catalyst in the folate metabolism pathway, the byproducts of which are involved in the remethylation of homocysteine to methionine. Methionine is a precursor for a major DNA methyl donor and is important for DNA methylation and gene regulation. Rare mutations in the MTHFR gene have been associated with autosomal recessive MTHFR deficiency leading to homocystinuria. In addition, two polymorphic variants in this gene (C677T and A1298C) have been implicated in a mild form of MTHFR deficiency associated with hyperhomocysteinemia...
October 2016: Journal of Genetic Counseling
https://www.readbyqxmd.com/read/27061234/folate-deficiency-and-over-supplementation-causes-impaired-folate-metabolism-regulation-and-adaptation-mechanisms-in-caenorhabditis-elegans
#10
Martina Ortbauer, Doris Ripper, Thomas Fuhrmann, Maximilian Lassi, Sandra Auernigg-Haselmaier, Christina Stiegler, Jürgen König
SCOPE: Impaired folate metabolism increases the risk of birth defects, neurodegenerative and cardiovascular disease, osteoporosis and cancer. We used Caenorhabditis elegans to investigate impaired folate metabolism by RNA interference of key enzymes in the methionine synthase (MS) and thymidylate synthase (TS) cycle and by folate deficiency and over-supplementation feeding studies. METHODS AND RESULTS: Folate status is influenced by genetic variations (polymorphisms), folate deficiency and supplementation...
April 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/26427156/reference-interval-and-status-for-serum-folate-and-serum-vitamin-b12-in-a-norwegian-population
#11
Lutz Schwettmann, Siw Berbu
BACKGROUND: Deficiencies of folate and vitamin B12 lead to an elevated serum concentration of homocysteine which has been associated with many diseases including cardiovascular disease. Laboratory algorithms often include initial testing of serum folate and vitamin B12. Reference intervals for these vitamins can vary significantly among populations for which dietary intakes may be different. The aim of this study was to establish reference intervals in a Norwegian population and to assess the folate and vitamin B12 status related to reference intervals...
2015: Clinical Laboratory
https://www.readbyqxmd.com/read/26322161/vitamin-paradox-in-obesity-deficiency-or-excess
#12
REVIEW
Shi-Sheng Zhou, Da Li, Na-Na Chen, Yiming Zhou
Since synthetic vitamins were used to fortify food and as supplements in the late 1930s, vitamin intake has significantly increased. This has been accompanied by an increased prevalence of obesity, a condition associated with diabetes, hypertension, cardiovascular disease, asthma and cancer. Paradoxically, obesity is often associated with low levels of fasting serum vitamins, such as folate and vitamin D. Recent studies on folic acid fortification have revealed another paradoxical phenomenon: obesity exhibits low fasting serum but high erythrocyte folate concentrations, with high levels of serum folate oxidation products...
August 25, 2015: World Journal of Diabetes
https://www.readbyqxmd.com/read/26300625/folate-status-in-type-2-diabetic-patients-with-and-without-retinopathy
#13
Giulia Malaguarnera, Caterina Gagliano, Salvatore Salomone, Maria Giordano, Claudio Bucolo, Antonino Pappalardo, Filippo Drago, Filippo Caraci, Teresio Avitabile, Massimo Motta
BACKGROUND: Folate deficiency is associated with cardiovascular disease, megaloblastic anemia, and with hyperhomocysteinemia. This study has been undertaken to investigate the role of folate status during the progression of the diabetic retinopathy. METHODS: We measured the plasma levels of homocysteine, folic acid, and red cell folate in 70 diabetic type 2 patients with nonproliferative diabetic retinopathy (NPDR), 65 with proliferative diabetic retinopathy (PDR), 96 without diabetic retinopathy, and 80 healthy subjects used as a control group...
2015: Clinical Ophthalmology
https://www.readbyqxmd.com/read/26266420/homocysteine-metabolism-gene-polymorphisms-mthfr-c677t-mthfr-a1298c-mtr-a2756g-and-mtrr-a66g-jointly-elevate-the-risk-of-folate-deficiency
#14
RANDOMIZED CONTROLLED TRIAL
Wen-Xing Li, Shao-Xing Dai, Jun-Juan Zheng, Jia-Qian Liu, Jing-Fei Huang
Folate deficiency is strongly associated with cardiovascular disease. We aimed to explore the joint effect of the methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C, methionine synthase (MTR) A2756G, and methionine synthase reductase (MTRR) A66G polymorphisms on folate deficiency in a Chinese hypertensive population. A total of 480 subjects aged 28-75 were enrolled in this study from September 2005-December 2005 from six hospitals in different Chinese regions. Known genotypes were detected by PCR-RFLP methods and serum folate was measured by chemiluminescence immunoassay...
August 10, 2015: Nutrients
https://www.readbyqxmd.com/read/26110674/moderate-alcohol-consumption-and-colorectal-cancer-risk
#15
REVIEW
DawnKylee S Klarich, Susan M Brasser, Mee Young Hong
BACKGROUND: Heavy alcohol drinking is a risk factor for colorectal cancer (CRC); previous studies have shown a linear dose-dependent association between alcohol intake and CRC. However, some studies suggest that moderate alcohol consumption may have a protective effect, similar to that seen in cardiovascular disease. Other factors may interact with alcohol and contribute additional risk for CRC. We aimed to determine the association between moderate alcohol consumption, limited to 30 g of alcohol per day, by beverage type on CRC risk and to assess the effects of other factors that interact with alcohol to influence CRC risk...
August 2015: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/26071632/pyridoxal-5-phosphate-deficiency-is-associated-with-hyperhomocysteinemia-regardless-of-antioxidant-thiamine-riboflavin-cobalamine-and-folate-status-in-critically-ill-patients
#16
Jorge Molina-López, Daniela Florea, Bartolomé Quintero-Osso, Antonio Pérez de la Cruz, Manuel Rodríguez-Elvira, Elena Planells Del Pozo
BACKGROUND & AIMS: Critically ill patients develop severe stress, inflammation and a clinical state that may raise the utilization and metabolic replacement of pyridoxal-5'-phosphate decreasing their body reserves. This study was designed to assess the nutritional pyridoxal-5'-phosphate status in critical care patients with systemic inflammatory response syndrome, comparing them with a group of healthy people, and studying it's association with factors involved in the pyridoxine and other B vitamins metabolism, as the total antioxidant capacity and Hcy as cardiovascular risk biomarker...
June 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/25982389/maternal-micronutrient-deficiency-leads-to-alteration-in-the-kidney-proteome-in-rat-pups
#17
Shadab Ahmad, Trayambak Basak, K Anand Kumar, Gourav Bhardwaj, A Lalitha, Dilip K Yadav, Giriraj Ratan Chandak, Manchala Raghunath, Shantanu Sengupta
Maternal nutritional deficiency significantly perturbs the offspring's physiology predisposing them to metabolic diseases during adulthood. Vitamin B12 and folate are two such micronutrients, whose deficiency leads to elevated homocysteine levels. We earlier generated B12 and/or folate deficient rat models and using high-throughput proteomic approach, showed that maternal vitamin B12 deficiency modulates carbohydrate and lipid metabolism in the liver of pups through regulation of PPAR signaling pathway. In this study, using similar approach, we identified 26 differentially expressed proteins in the kidney of pups born to mothers fed with vitamin B12 deficient diet while only four proteins were identified in the folate deficient group...
September 8, 2015: Journal of Proteomics
https://www.readbyqxmd.com/read/25948668/genetic-modifiers-of-folate-vitamin-b-12-and-homocysteine-status-in-a-cross-sectional-study-of-the-canadian-population
#18
John Wr Zinck, Margaret de Groh, Amanda J MacFarlane
BACKGROUND: Genetic variation can cause variable responses to environmental stimuli. A number of single-nucleotide polymorphisms (SNPs) have been associated with B vitamin status or chronic diseases related to vitamin B-12 and folate metabolism. OBJECTIVE: Our objective was to identify associations between common SNPs in genes related to folate and vitamin B-12 metabolism or associated with B vitamin-related chronic diseases and biomarkers of nutrient status in a population exposed to folic acid fortification...
June 2015: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/25835234/homocysteine-but-not-serum-amyloid-a-vitamin-a-and-e-related-to-increased-risk-of-metabolic-syndrome-in-post-menopausal-thai-women
#19
Kanjana Suriyaprom, Benjaluck Phonrat, Pratana Satitvipawee, Anchalee Tungtrongchitr, Rungsunn Tungtrongchitr
This study aims to investigate serum amyloid A, homocysteine, and biochemical-anthropometric measurements in post-menopausal women with and without metabolic syndrome (MS), and determine whether serum amyloid A and homocysteine are linked to MS among this group. This study was performed with 405 post-menopausal Thai volunteers with a mean age of 57.95±5.90 years (135 subjects with MS and 270 subjects without MS). The levels of serum amyloid A, homocysteine, vitamins, glucose, and lipids were measured. Homocysteine levels were significantly higher in the group with MS than in that without MS (p<0...
2014: International Journal for Vitamin and Nutrition Research. Journal International de Vitaminologie et de Nutrition
https://www.readbyqxmd.com/read/25722508/vitamin-b12-deficiency-an-important-reversible-co-morbidity-in-neuropsychiatric-manifestations
#20
Thomas Gregor Issac, Soundararajan Soundarya, Rita Christopher, Sadanandavalli Retnaswami Chandra
BACKGROUND: Vitamin B12 deficiency is a common condition causing neurologic, cognitive, psychiatric, and mood symptoms. With varied religious, ethnic, and socioeconomic heterogeneity among the people in India greatly influencing their dietary habits and with the high prevalence of Helicobacter pylori infection, Vitamin B12 deficiency is not uncommon, but is often under recognized due to the lack of classical symptomatic presentation. MATERIALS AND METHODS: Retrospective study on Vitamin B12 deficiency with neuropsychiatric symptoms in patients who attended neurology, psychiatry, and geriatric OPDs for a period of 1 year in a specialized neuropsychiatric institute in South India...
January 2015: Indian Journal of Psychological Medicine
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