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larval debridement

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https://www.readbyqxmd.com/read/29131748/a-multicentre-clinical-evaluation-of-a-hydro-responsive-wound-dressing-the-glasgow-experience
#1
H Hodgson, D Davidson, A Duncan, J Guthrie, E Henderson, M MacDiarmid, K McGown, V Pollard, R Potter, A Rodgers, A Wilson, J Horner, M Doran, S Simm, R Taylor, A Rogers, M G Rippon, M Colgrave
OBJECTIVE: Our aim was to assess the effectiveness of hydro-responsive wound dressing (HRWD) in debridement and wound bed preparation of a variety of acute and chronic wounds that presented with devitalised tissue needing removal so that healing may proceed. METHOD: This was a non-comparative evaluation of acute and chronic wounds that required debridement as part of their normal treatment regimen. Clinicians recorded wound changes including a subjective assessment level of devitalised tissue and wound bed preparation, presence of pain, wound status (e...
November 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28888529/eyelid-inflammation-an-uncommon-cause-in-occidental-countries
#2
Hélène Devambez, Morgane Richeux, Maximilien Guericolas, Christophe Choquet, Enrique Casalino, Aiham Daniel Ghazali
BACKGROUND: Myiasis designates the infestation of live human and vertebrate animals with dipterous (two-winged) larvae (maggots) and is the fourth most common travel-associated skin disease. Furuncle is the most common aspect of cutaneous myiasis. CASE PRESENTATION: A 24-year-old Caucasian female had been back from Cap-Vert. She described pruritus, slight pain, and the sensation of a foreign body moving in the eyelid. Physical examination showed a single furuncle-like nodule with surrounding erythema and a central pore of the upper eyelid through which a serosanguinous fluid was exuding...
November 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28419727/endotoxin-testing-of-a-wound-debridement-device-containing-medicinal-lucilia-sericata-larvae
#3
Samantha F Pickles, David I Pritchard
Alimentary products of medicinal Lucilia sericata larvae are studied to determine their mechanisms of action, particularly in the contexts of wound debridement and disinfection. Furthermore, the larvae can be applied to patients in contained medical devices (such as the BioBag; BioMonde). Here, we tested the materials and larval content of the most commonly used debridement device (the "BB-50") to explore the possibility that endotoxins may be contributing to the bio-activity of the product, given that endotoxins are potent stimulants of cellular activation...
May 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28235562/urate-oxidase-produced-by-lucilia-sericata-medical-maggots-is-localized-in-malpighian-tubes-and-facilitates-allantoin-production
#4
Andre Baumann, Marisa Skaljac, Rüdiger Lehmann, Andreas Vilcinskas, Zdenӗk Franta
Lucilia sericata maggots are the only species currently approved for maggot debridement therapy (MDT), an alternative treatment for chronic and recalcitrant wounds. Maggots promote wound debridement, disinfection and healing by producing a complex mixture of proteins, peptides and low-molecular-weight compounds in their secretions and excretions, but the individual components are not well characterized at the molecular level. Here we investigated the purine catabolism pathway in L. sericata, focusing on the production of allantoin by Urate Oxidase (UO), which is thought to promote wound healing...
April 2017: Insect Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28117913/quality-control-of-a-medicinal-larval-lucilia-sericata-debridement-device-based-on-released-gelatinase-activity
#5
S F Pickles, D I Pritchard
Lucilia sericata Meigen (Diptera: Calliphoridae) larvae are manufactured worldwide for the treatment of chronic wounds. Published research has confirmed that the primary clinical effect of the product, debridement (the degradation of non-viable wound tissue), is accomplished by a range of enzymes released by larvae during feeding. The quality assessment of larval activity is currently achieved during production using meat-based assays, which monitor insect growth and/or the reduction in substrate mass. To support this, the present authors developed a complementary radial diffusion enzymatic assay to produce a visual and measureable indication of the activity of larval alimentary products (LAP) collected under standardized conditions, against a gelatin substrate...
June 2017: Medical and Veterinary Entomology
https://www.readbyqxmd.com/read/27696133/first-record-of-larval-secretions-of-cochliomyia-macellaria-fabricius-1775-diptera-calliphoridae-inhibiting-the-growth-of-staphylococcus-aureus-and-pseudomonas-aeruginosa
#6
F S Masiero, M F K Aquino, M P Nassu, D I B Pereira, D S Leite, P J Thyssen
Maggot debridement therapy (MDT) consists on the intentional and controlled application of sterilized larvae of the order Diptera on necrotic skin lesions with the purpose of cleaning necrotic tissue and removing pathogenic bacteria. During MDT, a marked antimicrobial activity has been reported in literature specially associated with antibacterial substances from Lucilia sericata (Meigen); however, regarding Cochliomyia macellaria (Fabricius), little is known. This study aimed to evaluate in vitro inhibition of bacterial growth of Pseudomonas aeruginosa and Staphylococcus aureus in contact with excretions and secretions (ES) from C...
February 2017: Neotropical Entomology
https://www.readbyqxmd.com/read/27567983/anti-leishmania-activity-of-lucilia-sericata-and-calliphora-vicina-maggots-in-laboratory-models
#7
Alireza Sanei-Dehkordi, Ali Khamesipour, Kamran Akbarzadeh, Amir Ahmad Akhavan, Akram Mir Amin Mohammadi, Younes Mohammadi, Yavar Rassi, Mohammad Ali Oshaghi, Zahra Alebrahim, Seyed Ebrahim Eskandari, Javad Rafinejad
Use of sterile fly larvae (maggots) of blow flies for the treatment of many different types of skin and soft tissue wounds is called Maggot debridement therapy (MDT). The larvae of blow flies secrete a broad spectrum of compounds with diverse mechanisms of action in the gut and salivary glands called excretion/secretion (ES) products which showed to have antimicrobial activities against Gram negative and positive bacteria. Cutaneous leishmaniasis (CL) which is the common form of leishmaniasis is difficult to treat...
November 2016: Experimental Parasitology
https://www.readbyqxmd.com/read/27390689/safety-effectiveness-and-economic-aspects-of-maggot-debridement-therapy-for-wound-healing
#8
Jalal Arabloo, Serajaddin Grey, Mohammadreza Mobinizadeh, Alireza Olyaeemanesh, Pejman Hamouzadeh, Kiumars Khamisabadi
BACKGROUND: Maggot therapy has recently attracted considerable attention as an emerging debridement technique for wound healing. This study aimed to review the safety, effectiveness and economic evaluations of Maggot Debridement Therapy for wound healing. METHODS: To retrieve the relevant evidences, the Cochrane Library (until September 2014) was searched by appropriate keywords, using free text and Mesh. Systematic reviews, HTA reports and economic evaluation studies that compared larval therapy with other debridement therapies, such as hydrogel in patients with various kinds of ulcers in terms of side effects, the wound healing rate, the healing time, and cost per QALY, were included...
2016: Medical Journal of the Islamic Republic of Iran
https://www.readbyqxmd.com/read/27119084/next-generation-sequencing-identifies-five-major-classes-of-potentially-therapeutic-enzymes-secreted-by-lucilia-sericata-medical-maggots
#9
Zdeněk Franta, Heiko Vogel, Rüdiger Lehmann, Oliver Rupp, Alexander Goesmann, Andreas Vilcinskas
Lucilia sericata larvae are used as an alternative treatment for recalcitrant and chronic wounds. Their excretions/secretions contain molecules that facilitate tissue debridement, disinfect, or accelerate wound healing and have therefore been recognized as a potential source of novel therapeutic compounds. Among the substances present in excretions/secretions various peptidase activities promoting the wound healing processes have been detected but the peptidases responsible for these activities remain mostly unidentified...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27041484/methods-for-external-disinfection-of-blow-fly-diptera-calliphoridae-eggs-prior-to-use-in-wound-debridement-therapy
#10
Adrienne L Brundage, Tawni L Crippen, Jeffery K Tomberlin
Maggot debridement therapy (MDT) is the use of the larval stage of flies (i.e., Calliphoridae) to remove necrotic tissue and disinfect wounds. Effective MDT requires aseptic technique to prevent the unintentional introduction of pathogenic bacteria into a wound to be debrided; yet the external surface of Calliphoridae eggs is often heavily contaminated with bacteria. Studies of external disinfection of dipteran eggs have been reported, but neither their efficacy nor effect on egg viability has been adequately assessed...
March 2016: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/27006073/towards-next-generation-maggot-debridement-therapy-transgenic-lucilia-sericata-larvae-that-produce-and-secrete-a-human-growth-factor
#11
Rebecca J Linger, Esther J Belikoff, Ying Yan, Fang Li, Holly A Wantuch, Helen L Fitzsimons, Maxwell J Scott
BACKGROUND: Diabetes and its concurrent complications impact a significant proportion of the population of the US and create a large financial burden on the American health care system. FDA-approved maggot debridement therapy (MDT), the application of sterile laboratory-reared Lucilia sericata (green bottle fly) larvae to wounds, is a cost-effective and successful treatment for diabetic foot ulcers and other medical conditions. Human platelet derived growth factor-BB (PDGF-BB) is a secreted dimeric peptide growth factor that binds the PDGF receptor...
2016: BMC Biotechnology
https://www.readbyqxmd.com/read/26976407/evaluation-of-conventional-therapeutic-methods-versus-maggot-therapy-in-the-evolution-of-healing-of-tegumental-injuries-in-wistar-rats-with-and-without-diabetes-mellitus
#12
Franciéle Souza Masiero, Patricia Jacqueline Thyssen
Larval therapy consists on the application of sterilized carrion flies larvae, reared in laboratory, on acute, chronic, and/or infected wounds in order to promote healing. Conventional methods for treating injuries include mechanical debridement or silver-based dressings; however, they are not always effective for wound healing. Larval therapy is a feasible and safe treatment for therapeutic application and, in many cases, the only and the most recommended alternative for difficult healing injuries. Thus, this study aimed to evaluate the competence of Cochliomyia macellaria F...
June 2016: Parasitology Research
https://www.readbyqxmd.com/read/26804366/a-systematic-review-and-meta-analysis-of-d%C3%A3-bridement-methods-for-chronic-diabetic-foot-ulcers
#13
REVIEW
Tarig Elraiyah, Juan Pablo Domecq, Gabriela Prutsky, Apostolos Tsapas, Mohammed Nabhan, Robert G Frykberg, Rim Hasan, Belal Firwana, Larry J Prokop, Mohammad Hassan Murad
BACKGROUND: Several methods of débridement of diabetic foot ulcers are currently used. The relative efficacy of these methods is not well established. METHODS: This systematic review and meta-analysis was conducted to find the best available evidence for the effect of débridement on diabetic foot wound outcomes. We searched MEDLINE, Embase, Cochrane Central Register of Controlled Trials, Web of Science, and Scopus through October 2011 for randomized controlled studies (RCTs) and observational comparative studies...
February 2016: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/26546725/evaluating-sarconesiopsis-magellanica-blowfly-derived-larval-therapy-and-comparing-it-to-lucilia-sericata-derived-therapy-in-an-animal-model
#14
COMPARATIVE STUDY
Andrea Díaz-Roa, María A Gaona, Nidya A Segura, Alejandro Ramírez-Hernández, Jesús A Cortés-Vecino, Manuel A Patarroyo, Felio Bello
Larval therapy is used as alternative treatment for hard-to-heal chronic and infected wounds. Lucilia sericata is the most used blowfly species. However, it has been shown recently that Sarconesiopsis magellanica larval excretions and secretions have potent antibacterial activity; this blowfly belongs to the Calliphoridae family. The present work has dealt with evaluating larval therapy using S. magellanica on wounds induced in diabetic rabbits and its action was compared to the effect induced by L. sericata...
February 2016: Acta Tropica
https://www.readbyqxmd.com/read/26463514/the-impacts-of-larval-density-and-protease-inhibition-on-feeding-in-medicinal-larvae-of-the-greenbottle-fly-lucilia-sericata
#15
M R Wilson, Y Nigam, W Jung, J Knight, D I Pritchard
Larval therapy, the therapeutic use of blowfly larvae to treat chronic wounds, is primarily used in debridement. There are, however, gaps in current knowledge of the optimal clinical application of the therapy and mechanisms of action in the debridement process. Using an artificial assay, two studies were undertaken to investigate these aspects of larval debridement by Lucilia sericata Meigen (Diptera: Calliphoridae); the first studied the effects of the density of larvae on tissue digestion and larval mass, and the second considered the effects on the same parameters of incorporating protease inhibitors into the feeding substrate...
March 2016: Medical and Veterinary Entomology
https://www.readbyqxmd.com/read/26382290/growth-and-survival-of-blowfly-lucilia-sericata-larvae-under-simulated-wound-conditions-implications-for-maggot-debridement-therapy
#16
H Čičková, M Kozánek, P Takáč
Maggot debridement therapy has become a well-established method of wound debridement. Despite its success, little information is available about the optimum duration of the treatment cycle and larval growth in wounds. This study examines the development of Lucilia sericata (Diptera: Calliphoridae) larvae under two containment conditions (bagged and free range) under simulated wound conditions and assesses the impact of transport and further storage of larvae on their survival and growth. There was no significant difference in size between bagged and free-range larvae over the 72-h experimental period...
December 2015: Medical and Veterinary Entomology
https://www.readbyqxmd.com/read/26252388/selection-and-evaluation-of-tissue-specific-reference-genes-in-lucilia-sericata-during-an-immune-challenge
#17
Andre Baumann, Rüdiger Lehmann, Annika Beckert, Andreas Vilcinskas, Zdeněk Franta
The larvae of the common green bottle fly Lucilia sericata (Diptera: Calliphoridae) have been used for centuries to promote wound healing, but the molecular basis of their antimicrobial, debridement and healing functions remains largely unknown. The analysis of differential gene expression in specific larval tissues before and after immune challenge could be used to identify key molecular factors, but the most sensitive and reproducible method qRT-PCR requires validated reference genes. We therefore selected 10 candidate reference genes encoding products from different functional classes (18S rRNA, 28S rRNA, actin, β-tubulin, RPS3, RPLP0, EF1α, PKA, GAPDH and GST1)...
2015: PloS One
https://www.readbyqxmd.com/read/26187499/eradication-of-advanced-pelvic-hydatid-bone-disease-after-limb-salvage-surgery-5-year-follow-up-a-case-report
#18
Muhammad Shahid Khan, Pervaiz Mehmood Hashmi, Dawar Khan
INTRODUCTION: Echinococcosis is produced by the larval stage of Echinococcus granulosus; it is a parasitic disease which is seen rarely in humans and has adverse outcomes. We report a case of advanced pelvic hydatid bone disease with successful limb salvage surgery. Our patient had a 5-year follow-up without recurrence which is a rarity as per the literature. Early diagnosis and prompt medical therapy are necessary for effective management whereas delayed diagnosis is always fraught with the risk of recurrence and sepsis...
2015: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/26179750/time-management-by-medicinal-larvae
#19
David I Pritchard, Václav Čeřovský, Yamni Nigam, Samantha F Pickles, Gwendolyn Cazander, Peter H Nibbering, Anke Bültemann, Wilhelm Jung
Wound bed preparation (WBP) is an integral part of the care programme for chronic wounds. The acronym TIME is used in the context of WBP and describes four barriers to healing in chronic wounds; namely, dead Tissue, Infection and inflammation, Moisture imbalance and a non-migrating Edge. Larval debridement therapy (LDT) stems from observations that larvae of the blowfly Lucilia sericata clean wounds of debris. Subsequent clinical studies have proven debriding efficacy, which is likely to occur as a result of enzymatically active alimentary products released by the insect...
August 2016: International Wound Journal
https://www.readbyqxmd.com/read/26022143/evaluation-of-larval-density-cochliomyia-macellaria-f-diptera-calliphoridae-for-therapeutic-use-in-the-recovery-of-tegumentar-injuries
#20
Mariana Prado Nassu, Patricia Jacqueline Thyssen
Larval therapy (LT) is the application of carrion flies (Diptera) sterile larvae on chronic or infected wounds to promote or accelerate the healing process. High cost and the development of resistance by certain groups of pathogenic bacteria to these drugs encouraged the resurgence of LT, currently used in approximately 20 countries and more recently in Brazil. This study evaluated the behavior and larval density of Cochliomyia macellaria F. (Calliphoridae), one of the most appropriate species for debridement of injuries with necrotic tissue...
September 2015: Parasitology Research
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