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larval debridement

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https://www.readbyqxmd.com/read/27696133/first-record-of-larval-secretions-of-cochliomyia-macellaria-fabricius-1775-diptera-calliphoridae-inhibiting-the-growth-of-staphylococcus-aureus-and-pseudomonas-aeruginosa
#1
F S Masiero, M F K Aquino, M P Nassu, D I B Pereira, D S Leite, P J Thyssen
Maggot debridement therapy (MDT) consists on the intentional and controlled application of sterilized larvae of the order Diptera on necrotic skin lesions with the purpose of cleaning necrotic tissue and removing pathogenic bacteria. During MDT, a marked antimicrobial activity has been reported in literature specially associated with antibacterial substances from Lucilia sericata (Meigen); however, regarding Cochliomyia macellaria (Fabricius), little is known. This study aimed to evaluate in vitro inhibition of bacterial growth of Pseudomonas aeruginosa and Staphylococcus aureus in contact with excretions and secretions (ES) from C...
October 1, 2016: Neotropical Entomology
https://www.readbyqxmd.com/read/27567983/anti-leishmania-activity-of-lucilia-sericata-and-calliphora-vicina-maggots-in-laboratory-models
#2
Alireza Sanei-Dehkordi, Ali Khamesipour, Kamran Akbarzadeh, Amir Ahmad Akhavan, Akram Mir Amin Mohammadi, Younes Mohammadi, Yavar Rassi, Mohammad Ali Oshaghi, Zahra Alebrahim, Seyed Ebrahim Eskandari, Javad Rafinejad
Use of sterile fly larvae (maggots) of blow flies for the treatment of many different types of skin and soft tissue wounds is called Maggot debridement therapy (MDT). The larvae of blow flies secrete a broad spectrum of compounds with diverse mechanisms of action in the gut and salivary glands called excretion/secretion (ES) products which showed to have antimicrobial activities against Gram negative and positive bacteria. Cutaneous leishmaniasis (CL) which is the common form of leishmaniasis is difficult to treat...
August 24, 2016: Experimental Parasitology
https://www.readbyqxmd.com/read/27390689/safety-effectiveness-and-economic-aspects-of-maggot-debridement-therapy-for-wound-healing
#3
Jalal Arabloo, Serajaddin Grey, Mohammadreza Mobinizadeh, Alireza Olyaeemanesh, Pejman Hamouzadeh, Kiumars Khamisabadi
BACKGROUND: Maggot therapy has recently attracted considerable attention as an emerging debridement technique for wound healing. This study aimed to review the safety, effectiveness and economic evaluations of Maggot Debridement Therapy for wound healing. METHODS: To retrieve the relevant evidences, the Cochrane Library (until September 2014) was searched by appropriate keywords, using free text and Mesh. Systematic reviews, HTA reports and economic evaluation studies that compared larval therapy with other debridement therapies, such as hydrogel in patients with various kinds of ulcers in terms of side effects, the wound healing rate, the healing time, and cost per QALY, were included...
2016: Medical Journal of the Islamic Republic of Iran
https://www.readbyqxmd.com/read/27119084/next-generation-sequencing-identifies-five-major-classes-of-potentially-therapeutic-enzymes-secreted-by-lucilia-sericata-medical-maggots
#4
Zdeněk Franta, Heiko Vogel, Rüdiger Lehmann, Oliver Rupp, Alexander Goesmann, Andreas Vilcinskas
Lucilia sericata larvae are used as an alternative treatment for recalcitrant and chronic wounds. Their excretions/secretions contain molecules that facilitate tissue debridement, disinfect, or accelerate wound healing and have therefore been recognized as a potential source of novel therapeutic compounds. Among the substances present in excretions/secretions various peptidase activities promoting the wound healing processes have been detected but the peptidases responsible for these activities remain mostly unidentified...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27041484/methods-for-external-disinfection-of-blow-fly-diptera-calliphoridae-eggs-prior-to-use-in-wound-debridement-therapy
#5
Adrienne L Brundage, Tawni L Crippen, Jeffery K Tomberlin
Maggot debridement therapy (MDT) is the use of the larval stage of flies (i.e., Calliphoridae) to remove necrotic tissue and disinfect wounds. Effective MDT requires aseptic technique to prevent the unintentional introduction of pathogenic bacteria into a wound to be debrided; yet the external surface of Calliphoridae eggs is often heavily contaminated with bacteria. Studies of external disinfection of dipteran eggs have been reported, but neither their efficacy nor effect on egg viability has been adequately assessed...
March 2016: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/27006073/towards-next-generation-maggot-debridement-therapy-transgenic-lucilia-sericata-larvae-that-produce-and-secrete-a-human-growth-factor
#6
Rebecca J Linger, Esther J Belikoff, Ying Yan, Fang Li, Holly A Wantuch, Helen L Fitzsimons, Maxwell J Scott
BACKGROUND: Diabetes and its concurrent complications impact a significant proportion of the population of the US and create a large financial burden on the American health care system. FDA-approved maggot debridement therapy (MDT), the application of sterile laboratory-reared Lucilia sericata (green bottle fly) larvae to wounds, is a cost-effective and successful treatment for diabetic foot ulcers and other medical conditions. Human platelet derived growth factor-BB (PDGF-BB) is a secreted dimeric peptide growth factor that binds the PDGF receptor...
2016: BMC Biotechnology
https://www.readbyqxmd.com/read/26976407/evaluation-of-conventional-therapeutic-methods-versus-maggot-therapy-in-the-evolution-of-healing-of-tegumental-injuries-in-wistar-rats-with-and-without-diabetes-mellitus
#7
Franciéle Souza Masiero, Patricia Jacqueline Thyssen
Larval therapy consists on the application of sterilized carrion flies larvae, reared in laboratory, on acute, chronic, and/or infected wounds in order to promote healing. Conventional methods for treating injuries include mechanical debridement or silver-based dressings; however, they are not always effective for wound healing. Larval therapy is a feasible and safe treatment for therapeutic application and, in many cases, the only and the most recommended alternative for difficult healing injuries. Thus, this study aimed to evaluate the competence of Cochliomyia macellaria F...
June 2016: Parasitology Research
https://www.readbyqxmd.com/read/26804366/a-systematic-review-and-meta-analysis-of-d%C3%A3-bridement-methods-for-chronic-diabetic-foot-ulcers
#8
REVIEW
Tarig Elraiyah, Juan Pablo Domecq, Gabriela Prutsky, Apostolos Tsapas, Mohammed Nabhan, Robert G Frykberg, Rim Hasan, Belal Firwana, Larry J Prokop, Mohammad Hassan Murad
BACKGROUND: Several methods of débridement of diabetic foot ulcers are currently used. The relative efficacy of these methods is not well established. METHODS: This systematic review and meta-analysis was conducted to find the best available evidence for the effect of débridement on diabetic foot wound outcomes. We searched MEDLINE, Embase, Cochrane Central Register of Controlled Trials, Web of Science, and Scopus through October 2011 for randomized controlled studies (RCTs) and observational comparative studies...
February 2016: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/26546725/evaluating-sarconesiopsis-magellanica-blowfly-derived-larval-therapy-and-comparing-it-to-lucilia-sericata-derived-therapy-in-an-animal-model
#9
COMPARATIVE STUDY
Andrea Díaz-Roa, María A Gaona, Nidya A Segura, Alejandro Ramírez-Hernández, Jesús A Cortés-Vecino, Manuel A Patarroyo, Felio Bello
Larval therapy is used as alternative treatment for hard-to-heal chronic and infected wounds. Lucilia sericata is the most used blowfly species. However, it has been shown recently that Sarconesiopsis magellanica larval excretions and secretions have potent antibacterial activity; this blowfly belongs to the Calliphoridae family. The present work has dealt with evaluating larval therapy using S. magellanica on wounds induced in diabetic rabbits and its action was compared to the effect induced by L. sericata...
February 2016: Acta Tropica
https://www.readbyqxmd.com/read/26463514/the-impacts-of-larval-density-and-protease-inhibition-on-feeding-in-medicinal-larvae-of-the-greenbottle-fly-lucilia-sericata
#10
M R Wilson, Y Nigam, W Jung, J Knight, D I Pritchard
Larval therapy, the therapeutic use of blowfly larvae to treat chronic wounds, is primarily used in debridement. There are, however, gaps in current knowledge of the optimal clinical application of the therapy and mechanisms of action in the debridement process. Using an artificial assay, two studies were undertaken to investigate these aspects of larval debridement by Lucilia sericata Meigen (Diptera: Calliphoridae); the first studied the effects of the density of larvae on tissue digestion and larval mass, and the second considered the effects on the same parameters of incorporating protease inhibitors into the feeding substrate...
March 2016: Medical and Veterinary Entomology
https://www.readbyqxmd.com/read/26382290/growth-and-survival-of-blowfly-lucilia-sericata-larvae-under-simulated-wound-conditions-implications-for-maggot-debridement-therapy
#11
H Čičková, M Kozánek, P Takáč
Maggot debridement therapy has become a well-established method of wound debridement. Despite its success, little information is available about the optimum duration of the treatment cycle and larval growth in wounds. This study examines the development of Lucilia sericata (Diptera: Calliphoridae) larvae under two containment conditions (bagged and free range) under simulated wound conditions and assesses the impact of transport and further storage of larvae on their survival and growth. There was no significant difference in size between bagged and free-range larvae over the 72-h experimental period...
December 2015: Medical and Veterinary Entomology
https://www.readbyqxmd.com/read/26252388/selection-and-evaluation-of-tissue-specific-reference-genes-in-lucilia-sericata-during-an-immune-challenge
#12
Andre Baumann, Rüdiger Lehmann, Annika Beckert, Andreas Vilcinskas, Zdeněk Franta
The larvae of the common green bottle fly Lucilia sericata (Diptera: Calliphoridae) have been used for centuries to promote wound healing, but the molecular basis of their antimicrobial, debridement and healing functions remains largely unknown. The analysis of differential gene expression in specific larval tissues before and after immune challenge could be used to identify key molecular factors, but the most sensitive and reproducible method qRT-PCR requires validated reference genes. We therefore selected 10 candidate reference genes encoding products from different functional classes (18S rRNA, 28S rRNA, actin, β-tubulin, RPS3, RPLP0, EF1α, PKA, GAPDH and GST1)...
2015: PloS One
https://www.readbyqxmd.com/read/26187499/eradication-of-advanced-pelvic-hydatid-bone-disease-after-limb-salvage-surgery-5-year-follow-up-a-case-report
#13
Muhammad Shahid Khan, Pervaiz Mehmood Hashmi, Dawar Khan
INTRODUCTION: Echinococcosis is produced by the larval stage of Echinococcus granulosus; it is a parasitic disease which is seen rarely in humans and has adverse outcomes. We report a case of advanced pelvic hydatid bone disease with successful limb salvage surgery. Our patient had a 5-year follow-up without recurrence which is a rarity as per the literature. Early diagnosis and prompt medical therapy are necessary for effective management whereas delayed diagnosis is always fraught with the risk of recurrence and sepsis...
2015: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/26179750/time-management-by-medicinal-larvae
#14
David I Pritchard, Václav Čeřovský, Yamni Nigam, Samantha F Pickles, Gwendolyn Cazander, Peter H Nibbering, Anke Bültemann, Wilhelm Jung
Wound bed preparation (WBP) is an integral part of the care programme for chronic wounds. The acronym TIME is used in the context of WBP and describes four barriers to healing in chronic wounds; namely, dead Tissue, Infection and inflammation, Moisture imbalance and a non-migrating Edge. Larval debridement therapy (LDT) stems from observations that larvae of the blowfly Lucilia sericata clean wounds of debris. Subsequent clinical studies have proven debriding efficacy, which is likely to occur as a result of enzymatically active alimentary products released by the insect...
August 2016: International Wound Journal
https://www.readbyqxmd.com/read/26022143/evaluation-of-larval-density-cochliomyia-macellaria-f-diptera-calliphoridae-for-therapeutic-use-in-the-recovery-of-tegumentar-injuries
#15
Mariana Prado Nassu, Patricia Jacqueline Thyssen
Larval therapy (LT) is the application of carrion flies (Diptera) sterile larvae on chronic or infected wounds to promote or accelerate the healing process. High cost and the development of resistance by certain groups of pathogenic bacteria to these drugs encouraged the resurgence of LT, currently used in approximately 20 countries and more recently in Brazil. This study evaluated the behavior and larval density of Cochliomyia macellaria F. (Calliphoridae), one of the most appropriate species for debridement of injuries with necrotic tissue...
September 2015: Parasitology Research
https://www.readbyqxmd.com/read/25903008/histological-patterns-in-healing-chronic-wounds-using-cochliomyia-macellaria-diptera-calliphoridae-larvae-and-other-therapeutic-measures
#16
Franciéle Souza de Masiero, Mariana Prado Nassu, Mauro Pereira Soares, Patricia Jacqueline Thyssen
The healing process occurs due to the interaction of cellular, molecular, and biochemical events. Regarding lesions difficult to heal, especially in immunocompromised patients, monitoring and intervention to promote healing is a constant focus of research. Another aggravating factor is the increase in the number of reported cases of microbial resistance, indicating that various dressings and drugs have been increasingly inefficient. Larval therapy (LT) involves the application of sterile fly larvae on chronic and/or infected wounds, and it is an area emerging as an alternative therapy...
August 2015: Parasitology Research
https://www.readbyqxmd.com/read/25306907/a-metagenomic-assessment-of-the-bacteria-associated-with-lucilia-sericata-and-lucilia-cuprina-diptera-calliphoridae
#17
Baneshwar Singh, Tawni L Crippen, Longyu Zheng, Andrew T Fields, Ziniu Yu, Qun Ma, Thomas K Wood, Scot E Dowd, Micah Flores, Jeffery K Tomberlin, Aaron M Tarone
Lucilia Robineau-Desvoidy (Diptera: Calliphoridae) is a blow fly genus of forensic, medical, veterinary, and agricultural importance. This genus is also famous because of its beneficial uses in maggot debridement therapy (MDT). Although the genus is of considerable economic importance, our knowledge about microbes associated with these flies and how these bacteria are horizontally and trans-generationally transmitted is limited. In this study, we characterized bacteria associated with different life stages of Lucilia sericata (Meigen) and Lucilia cuprina (Wiedemann) and in the salivary gland of L...
January 2015: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/25300315/maggots-as-a-wound-debridement-agent-for-chronic-venous-leg-ulcers-under-graduated-compression-bandages-a-randomised-controlled-trial
#18
RANDOMIZED CONTROLLED TRIAL
C E Davies, G Woolfrey, N Hogg, J Dyer, A Cooper, J Waldron, R Bulbulia, M R Whyman, K R Poskitt
OBJECTIVES: Slough in chronic venous leg ulcers may be associated with delayed healing. The purpose of this study was to assess larval debridement in chronic venous leg ulcers and to assess subsequent effect on healing. METHODS: All patients with chronic leg ulcers presenting to the leg ulcer service were evaluated for the study. Exclusion criteria were: ankle brachial pressure indices <0.85 or >1.25, no venous reflux on duplex and <20% of ulcer surface covered with slough...
December 2015: Phlebology
https://www.readbyqxmd.com/read/25098233/midgut-lysozymes-of-lucilia-sericata-new-antimicrobials-involved-in-maggot-debridement-therapy
#19
I Valachova, P Takac, J Majtan
Larvae of Lucilia sericata are used for maggot debridement therapy (MDT) because of their ability to remove necrotic tissue and eradicate bacterial pathogens of infected wounds. So far, very few antibacterial factors have been fully characterized (eg lucifensin). Using a molecular approach, some other putative antimicrobial compounds, including three novel lysozymes, have been previously identified and predicted to be involved in MDT. Nevertheless, data on lysozymes tissue origin and their functions have never been elucidated...
December 2014: Insect Molecular Biology
https://www.readbyqxmd.com/read/24861094/maggot-therapy-for-elephantiasis-nostras-verrucosa-reveals-new-applications-and-new-complications-a-case-report
#20
Gregory M Borst, Claudia E Goettler, Swapnil D Kachare, Ronald A Sherman
Elephantiasis nostras verrucosa (ENV) is a rare dermatologic condition caused by chronic nonfilarial lymphedema. The treatment for ENV is challenging and based solely on case reports. We report novel therapy for ENV with maggot debridement therapy (MDT), an effective wound therapy that has gained popularity with the rise of antimicrobial resistance. MDT, in combination with tangential surgical debridement, was effective in the treatment of ENV. In nature, sheep infested with more than 16 000 blow fly larvae exhibit ammonia toxicity...
June 2014: International Journal of Lower Extremity Wounds
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