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https://www.readbyqxmd.com/read/29131748/a-multicentre-clinical-evaluation-of-a-hydro-responsive-wound-dressing-the-glasgow-experience
#1
H Hodgson, D Davidson, A Duncan, J Guthrie, E Henderson, M MacDiarmid, K McGown, V Pollard, R Potter, A Rodgers, A Wilson, J Horner, M Doran, S Simm, R Taylor, A Rogers, M G Rippon, M Colgrave
OBJECTIVE: Our aim was to assess the effectiveness of hydro-responsive wound dressing (HRWD) in debridement and wound bed preparation of a variety of acute and chronic wounds that presented with devitalised tissue needing removal so that healing may proceed. METHOD: This was a non-comparative evaluation of acute and chronic wounds that required debridement as part of their normal treatment regimen. Clinicians recorded wound changes including a subjective assessment level of devitalised tissue and wound bed preparation, presence of pain, wound status (e...
November 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/29122715/nematicidal-activity-of-a-water-soluble-lectin-from-seeds-of-moringa-oleifera
#2
Mário Luan Silva de Medeiros, Maiara Celine de Moura, Thiago Henrique Napoleão, Patrícia Maria Guedes Paiva, Luana Cassandra Breitenbach Barroso Coelho, Ana Carla Diógenes Suassuna Bezerra, Michele Dalvina Correia da Silva
Gastrointestinal nematodes are the major cause of animal diseases, and the indiscriminate use of synthetic anthelmintic contributes to the development of drug resistance. Natural bioproducts are noteworthy since they have proved to be promising for alternative antiparasitic therapies. This study evaluated the in vitro effect of WSMoL (water soluble Moringa oleifera lectin) on hatching of eggs and on the development of early-stage larvae of gastrointestinal nematodes from naturally infected goats. In addition, the interference of WSMoL on activity of proteases was determined and the affinity of the lectin for glycosylated molecules of these parasites was investigated using fluorescein isothiocyanate (FITC)-labeled WSMoL...
November 6, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29061647/pyridoxine-dependent-epilepsy-in-zebrafish-caused-by-aldh7a1-deficiency
#3
Izabella A Pena, Yann Roussel, Kate Daniel, Kevin Mongeon, Devon Johnstone, Hellen Weinschutz Mendes, Marjolein Bosma, Vishal Saxena, Nathalie Lepage, Pranesh Chakraborty, David A Dyment, Clara D M van Karnebeek, Nanda Verhoeven-Duif, Tuan Vu Bui, Kym M Boycott, Marc Ekker, Alex MacKenzie
Pyridoxine-dependent epilepsy (PDE) is a rare disease characterized by mutations in the lysine degradation gene ALDH7A1 leading to recurrent neonatal seizures which are uniquely alleviated by high doses of pyridoxine or pyridoxal 5'-phosphate (vitamin B6 vitamers). Despite treatment, neurodevelopmental disabilities are still observed in most PDE patients underlining the need for adjunct therapies. Over 60 years after the initial description of PDE, we report the first animal model for this disease: an aldh7a1-null zebrafish (Danio rerio) displaying deficient lysine metabolism and spontaneous and recurrent seizures in the larval stage (10 dpf)...
October 23, 2017: Genetics
https://www.readbyqxmd.com/read/29061197/in-vivo-evaluation-of-the-efficacy-of-sophora-moorcroftiana-alkaloids-in-combination-with-bacillus-calmette-gu%C3%A3-rin-bcg-treatment-for-cystic-echinococcosis-in-mice
#4
G Zhang, J Wang, Y Luo, M Yuan, Q Gao, H Gao, X Song, Y Shi, K Dong, X Ma
Human cystic echinococcosis is a widespread, chronic, endemic, helminthic zoonosis caused by larval tapeworms of the species Echinococcus granulosus. At present, there is no rational and effective therapy for patients with echinococcosis. The present study evaluated whether the combination of alkaloids from Sophora moorcroftiana seeds (SMSa2) and Bacillus Calmette-Guérin (BCG) was effective in the treatment of experimental echinococcosis. After 20 weeks of secondary infection with protoscoleces, mice were randomly allocated to five groups and treated for 6 weeks by daily intragastric administration of albendazole (ABZ, 100 mg/kg), SMSa2 (100 mg/kg), BCG (abdominal subcutaneous injection at 5 × 106 CFU), SMSa2 + BCG (100 mg/kg SMSa2 and 5 × 106 CFU BCG) or normal saline (untreated group), respectively...
October 24, 2017: Journal of Helminthology
https://www.readbyqxmd.com/read/29050919/anthelmintic-therapy-of-equine-cyathostomin-nematodes-larvicidal-efficacy-egg-reappearance-period-and-drug-resistance
#5
Jennifer L Bellaw, Kristen Krebs, Craig R Reinemeyer, Jamie K Norris, Jessica A Scare, Stefanie Pagano, Martin K Nielsen
Cyathostomins are ubiquitous in grazing horses across the world, and anthelmintic resistance has been reported with increasing levels over past decades. The aims of the present study were (i) to investigate the efficacy against encysted larval stages of moxidectin (0.4 mg/kg) and fenbendazole (10 mg/kg daily for five consecutive days) and compare these regimens at 2 and 5 weeks post-treatment, (ii) to investigate individual cyathostomin species associated with shortened egg reappearance periods, and (iii) to document species exhibiting decreased susceptibility to the evaluated compounds...
October 16, 2017: International Journal for Parasitology
https://www.readbyqxmd.com/read/28992315/amphotericin-b-and-terbinafine-but-not-the-azoles-prolong-survival-in-galleria-mellonella-larvae-infected-with-madurella-mycetomatis
#6
Wendy Kloezen, Florianne Parel, Roger Brüggemann, Khalid Asouit, Marilyn Helvert-van Poppel, Ahmed Fahal, Johan Mouton, Wendy van de Sande
Mycetoma is a tropical neglected disease characterized by large subcutaneous lesions in which the causative organisms reside in the form of grains. The most common causative agent is Madurella mycetomatis. Antifungal therapy often fails due to these grains, but to identify novel treatment options has been difficult since grains do not form in vitro. We recently used Galleria mellonella larvae to develop an in vivo grain model. In the current study, we set out to determine the therapeutic efficacy of commonly used antifungal agents in this larval model...
September 14, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28969840/experimental-cystic-echinococcosis-therapy-in-vitro-and-in-vivo-combined-5-fluorouracil-albendazole-treatment
#7
Patricia E Pensel, Natalia Elissondo, Guillermo Gambino, Gabriela Ullio Gamboa, J P Benoit, María C Elissondo
Human cystic echinococcosis is a zoonosis caused by the larval stage of the tapeworm Echinococcus granulosus sensu lato (s. l.). Although benzimidazole compounds such as albendazole (ABZ) and mebendazole have been the cornerstone of chemotherapy for the disease, there is often no complete recovery after treatment. Hence, new strategies are required to improve treatment of human cystic echinococcosis. The goals of the current study were as follows: (i) to evaluate the in vitro efficacy of the 5-fluorouracil (5-FU) and ABZ combination against E...
October 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28932037/fine-needle-aspiration-cytology-of-cysticercosis-in-submandibular-gland
#8
Vaneet Kaur Sandhu, Upender Sharma, Navtej Singh, Geetika Goyal
Fine-needle aspiration cytology (FNAC) has emerged as simple, minimally invasive, low-cost, outpatient diagnostic modality for the evaluation of nodules caused by parasites. Cysticercosis is caused by larval stage of Taenia solium, pork tapeworm. It is endemic in Southeast Asia, Latin America and South Africa. We report a case of cysticercosis in a 25-year-old male who presented with painless swelling of submandibular gland which was diagnosed on FNAC. The patient was recommended antihelminthic therapy which resulted in complete resolution of the swelling...
May 2017: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/28902964/plasmatic-coagulation-and-fibrinolysis-in-healthy-and-otostrongylus-affected-northern-elephant-seals-mirounga-angustirostris
#9
Sarrah Kaye, Shawn Johnson, Carlos Rios, Daniel J Fletcher
BACKGROUND: Prepatent Otostrongylus arteritis results in hemorrhagic diathesis in free-ranging Northern elephant seals (Mirounga angustirostris) attributed to aberrant larval migration of the lungworm, Otostrongylus circumlitus. Clinical signs are often nonspecific, including lethargy, anorexia, and blepharospasm, but can progress to spontaneous frank hemorrhage and death within 72 hours of onset. Previously published case reports describe coagulopathy with prolonged PT and APTT, normal to elevated platelet counts, normal antithrombin concentrations, and low concentrations of fibrinogen degradation products...
September 13, 2017: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/28732770/pharmacologic-modeling-of-primary-mitochondrial-respiratory-chain-dysfunction-in-zebrafish
#10
James Byrnes, Rebecca Ganetzky, Richard Lightfoot, Michael Tzeng, Eiko Nakamaru-Ogiso, Christoph Seiler, Marni J Falk
Mitochondrial respiratory chain (RC) disease is a heterogeneous and highly morbid group of energy deficiency disorders for which no proven effective therapies exist. Robust vertebrate animal models of primary RC dysfunction are needed to explore the effects of variation in RC disease subtypes, tissue-specific manifestations, and major pathogenic factors contributing to each disorder, as well as their pre-clinical response to therapeutic candidates. We have developed a series of zebrafish (Danio rerio) models that inhibit, to variable degrees, distinct aspects of RC function, and enable quantification of animal development, survival, behaviors, and organ-level treatment effects as well as effects on mitochondrial biochemistry and physiology...
July 18, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28639707/dressings-and-topical-agents-for-treating-pressure-ulcers
#11
REVIEW
Maggie J Westby, Jo C Dumville, Marta O Soares, Nikki Stubbs, Gill Norman
BACKGROUND: Pressure ulcers, also known as bedsores, decubitus ulcers and pressure injuries, are localised areas of injury to the skin or the underlying tissue, or both. Dressings are widely used to treat pressure ulcers and promote healing, and there are many options to choose from including alginate, hydrocolloid and protease-modulating dressings. Topical agents have also been used as alternatives to dressings in order to promote healing.A clear and current overview of all the evidence is required to facilitate decision-making regarding the use of dressings or topical agents for the treatment of pressure ulcers...
June 22, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28634159/a-role-for-the-nonsense-mediated-mrna-decay-pathway-in-maintaining-genome-stability-in-caenorhabditis-elegans
#12
Víctor González-Huici, Bin Wang, Anton Gartner
Ionizing radiation (IR) is commonly used in cancer therapy and is a main source of DNA double-strand breaks (DSBs), one of the most toxic forms of DNA damage. We have used Caenorhabditis elegans as an invertebrate model to identify novel factors required for repair of DNA damage inflicted by IR. We have performed an unbiased genetic screen, finding that smg-1 mutations confer strong hyper-sensitivity to IR. SMG-1 is a phosphoinositide-3 kinase (PI3K) involved in mediating nonsense-mediated mRNA decay (NMD) of transcripts containing premature stop codons and related to the ATM and ATR kinases which are at the apex of DNA damage signaling pathways...
August 2017: Genetics
https://www.readbyqxmd.com/read/28619365/aucklandia-lappa-dc-extract-enhances-gefitinib-efficacy-in-gefitinib-resistance-secondary-epidermal-growth-factor-receptor-mutations
#13
Guan Huang, Yanli Tong, Qidi He, Jie Wang, Zuanguang Chen
ETHNOPHARMACOLOGICAL RELEVANCE: Aucklandia lappa DC. is a widely used medicinal plant in China, India and Pakistan for a long time. Previously, a number of different pharmacological experiments in vitro and in vivo have convincingly demonstrated the abilities of it to exhibit anticancer activities. Reynoutria japonica Houtt. has also been widely used as traditional Chinese medicinal plant. Previous studies have demonstrated that it is bioactive to exhibit anticancer activities. AIM OF THE STUDY: This study aims to investigate whether the extracts of Aucklandia lappa DC...
July 12, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28615841/cobboldia-elephantis-cobbold-1866-larval-infestation-in-an-indian-elephant-elephas-maximus
#14
Ananda K Javare Gowda, N K Dharanesha, P Giridhar, S M Byre Gowda
In the present study, post-mortem was conducted on a female elephant aged about 37 years died at Rajeev Gandhi National Park, Hunsur, Mathigoodu Elephant Camp, Karnataka state. The animal suffered with diarrhoea, anorexia, dehydration and was unable to walk for about one week before death and was treated with antibiotics and fluid therapy for three days. The post-mortem examination revealed that, the gastric mucosa was severely congested, hyperaemic and numerous stomach bots attached to the mucosa. The bots were recovered from the gastric mucosa and processed for species identification...
June 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/28415697/down-regulation-of-interleukin-7-receptor-il-7r-contributes-to-central-nervous-system-demyelination
#15
Xudan Lei, Shijiao Cai, Yang Chen, Jianlin Cui, Yajie Wang, Zongjin Li, Yuhao Li
Interleukin 7 receptor (IL-7R) has been associated with the pathogenesis of multiple sclerosis (MS), though the mechanisms are not clear. Because myelin expression is highly conserved between zebrafish and mammals, zebrafish have become an ideal model for studying demyelination. We used a transgenic (Tg; mbp:nfsB-egfp) zebrafish line in which oligodendrocytes expressed green fluorescent protein (GFP) from the larval stage to adulthood. Exposing adult transgenic zebrafish to metronidazole induced demyelination that resembled the morphological changes associated with the early stages of MS...
April 25, 2017: Oncotarget
https://www.readbyqxmd.com/read/28292832/functional-organization-of-vestibulo-ocular-responses-in-abducens-motoneurons
#16
Haike Dietrich, Stefan Glasauer, Hans Straka
Vestibulo-ocular reflexes (VORs) are the dominating contributors to gaze stabilization in all vertebrates. During horizontal head movements, abducens motoneurons form the final element of the reflex arc that integrates visuovestibular inputs into temporally precise motor commands for the lateral rectus eye muscle. Here, we studied a possible differentiation of abducens motoneurons into subtypes by evaluating their morphology, discharge properties, and synaptic pharmacology in semi-intact in vitro preparations of larval Xenopus laevis Extracellular nerve recordings during sinusoidal head motion revealed a continuum of resting rates and activation thresholds during vestibular stimulation...
April 12, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28285998/a-non-cell-autonomous-role-of-bec-1-becn1-beclin1-in-coordinating-cell-cycle-progression-and-stem-cell-proliferation-during-germline-development
#17
Kristina Ames, Dayse S Da Cunha, Brenda Gonzalez, Marina Konta, Feng Lin, Gabriel Shechter, Lev Starikov, Sara Wong, Hannes E Bülow, Alicia Meléndez
The decision of stem cells to proliferate and differentiate is finely controlled. The Caenorhabditis elegans germline provides a tractable system for studying the mechanisms that control stem cell proliferation and homeostasis [1-4]. Autophagy is a conserved cellular recycling process crucial for cellular homeostasis in many different contexts [5], but its function in germline stem cell proliferation remains poorly understood. Here, we describe a function for autophagy in germline stem cell proliferation. We found that autophagy genes such as bec-1/BECN1/Beclin1, atg-16...
March 20, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28235562/urate-oxidase-produced-by-lucilia-sericata-medical-maggots-is-localized-in-malpighian-tubes-and-facilitates-allantoin-production
#18
Andre Baumann, Marisa Skaljac, Rüdiger Lehmann, Andreas Vilcinskas, Zdenӗk Franta
Lucilia sericata maggots are the only species currently approved for maggot debridement therapy (MDT), an alternative treatment for chronic and recalcitrant wounds. Maggots promote wound debridement, disinfection and healing by producing a complex mixture of proteins, peptides and low-molecular-weight compounds in their secretions and excretions, but the individual components are not well characterized at the molecular level. Here we investigated the purine catabolism pathway in L. sericata, focusing on the production of allantoin by Urate Oxidase (UO), which is thought to promote wound healing...
April 2017: Insect Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28182659/metformin-exhibits-preventive-and-therapeutic-efficacy-against-experimental-cystic-echinococcosis
#19
Julia A Loos, Valeria A Dávila, Christian R Rodrígues, Romina Petrigh, Jorge A Zoppi, Fernando A Crocenzi, Andrea C Cumino
Metformin (Met) is an anti-hyperglycemic and potential anti-cancer agent which may exert its anti-proliferative effects via the induction of energetic stress. In this study we investigated the in vitro and in vivo efficacy of Met against the larval stage of Echinococcus granulosus. Metformin showed significant dose- and time-dependent killing effects on in vitro cultured protoscoleces and metacestodes. Notably, the combination of Met together with the minimum effective concentration of ABZSO had a synergistic effect after days 3 and 12 on metacestodes and protoscoleces, respectively...
February 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28129859/investigating-microglia-brain-tumor-cell-interactions-in-vivo-in-the-larval-zebrafish-brain
#20
REVIEW
K R Astell, D Sieger
Glioblastoma is the most frequent and aggressive primary malignant brain tumor. Gliomas exhibit high genetic diversity in addition to complex and variable clinical features. Glioblastoma tumors are highly resistant to multimodal therapies and there is significant patient mortality within the first two years after prognosis. At present clinical treatments are palliative, not curative. Glioblastomas contain a high number of microglia and infiltrating macrophages, which are positively correlated with glioma grade and invasiveness...
2017: Methods in Cell Biology
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