keyword
MENU ▼
Read by QxMD icon Read
search

larval therapy

keyword
https://www.readbyqxmd.com/read/27824910/3d-finite-element-electrical-model-of-larval-zebrafish-ecg-signals
#1
James Crowcombe, Sundeep Singh Dhillon, Rhiannon Mary Hurst, Stuart Egginton, Ferenc Müller, Attila Sík, Edward Tarte
Assessment of heart function in zebrafish larvae using electrocardiography (ECG) is a potentially useful tool in developing cardiac treatments and the assessment of drug therapies. In order to better understand how a measured ECG waveform is related to the structure of the heart, its position within the larva and the position of the electrodes, a 3D model of a 3 days post fertilisation (dpf) larval zebrafish was developed to simulate cardiac electrical activity and investigate the voltage distribution throughout the body...
2016: PloS One
https://www.readbyqxmd.com/read/27822723/impact-of-safe-distance-on-long-term-outcome-after-surgical-therapy-of-alveolar-echinococcosis
#2
Andreas Hillenbrand, Beate Gruener, Wolfgang Kratzer, Peter Kern, Tilmann Graeter, Thomas F Barth, Klaus Buttenschoen, Doris Henne-Bruns
INTRODUCTION: In humans, alveolar echinococcosis (AE) is a serious helminthic disease. Additionally to a long-term medical treatment, in all suitable cases a complete surgical resection with a 20-mm safe distance (minimal distance of larval tissue to resection margin) is recommended. We analyzed the influence of the safe distance and the effect of the postoperative anthelmintic prophylaxis on the long-term outcome of patients who underwent surgery with curative intent. OBJECTIVE: Ninety-two operated patients were evaluated regarding the safe distance, the duration of medical therapy with benzimidazole derivates, and the further course of AE...
November 7, 2016: World Journal of Surgery
https://www.readbyqxmd.com/read/27806130/mycobacterium-abscessus-induced-granuloma-formation-is-strictly-dependent-on-tnf-signaling-and-neutrophil-trafficking
#3
Audrey Bernut, Mai Nguyen-Chi, Iman Halloum, Jean-Louis Herrmann, Georges Lutfalla, Laurent Kremer
Mycobacterium abscessus is considered the most common respiratory pathogen among the rapidly growing non-tuberculous mycobacteria. Infections with M. abscessus are increasingly found in patients with chronic lung diseases, especially cystic fibrosis, and are often refractory to antibiotic therapy. M. abscessus has two morphotypes with distinct effects on host cells and biological responses. The smooth (S) variant is recognized as the initial airway colonizer while the rough (R) is known to be a potent inflammatory inducer associated with invasive disease, but the underlying immunopathological mechanisms of the infection remain unsolved...
November 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27781073/a-classic-case-of-subcutaneous-cysticercosis-a-rare-case-with-sonological-findings-and-review-of-literature
#4
Srinivas M Naren Satya, Kamala Retnam Mayilvaganan, V N Amogh, B V Balakrishna, Munnangi Satya Gautam, Ivvala Sai Prathyusha
BACKGROUND: Cysticercosis is a parasitic infection caused by the larval stages of the pork tapeworm, Taenia solium. The subcutaneous form of the disease is a relatively rare clinical entity. Despite its rarity, it is imperative for a radiologist to be aware of this subcutaneous form of the disease and its various radiological patterns while evaluating any subcutaneous swelling. In this paper, we aimed to describe a typical case of 'subcutaneous cysticercosis involving the left anterior chest wall' with high resolution ultrasound findings...
2016: Polish Journal of Radiology
https://www.readbyqxmd.com/read/27696133/first-record-of-larval-secretions-of-cochliomyia-macellaria-fabricius-1775-diptera-calliphoridae-inhibiting-the-growth-of-staphylococcus-aureus-and-pseudomonas-aeruginosa
#5
F S Masiero, M F K Aquino, M P Nassu, D I B Pereira, D S Leite, P J Thyssen
Maggot debridement therapy (MDT) consists on the intentional and controlled application of sterilized larvae of the order Diptera on necrotic skin lesions with the purpose of cleaning necrotic tissue and removing pathogenic bacteria. During MDT, a marked antimicrobial activity has been reported in literature specially associated with antibacterial substances from Lucilia sericata (Meigen); however, regarding Cochliomyia macellaria (Fabricius), little is known. This study aimed to evaluate in vitro inhibition of bacterial growth of Pseudomonas aeruginosa and Staphylococcus aureus in contact with excretions and secretions (ES) from C...
October 1, 2016: Neotropical Entomology
https://www.readbyqxmd.com/read/27686957/the-effect-of-lucilia-sericata-and-sarconesiopsis-magellanica-derived-larval-therapy-on-leishmania-panamensis
#6
Lissa Cruz-Saavedra, Andrea Díaz-Roa, María A Gaona, Mónica L Cruz, Martha Ayala, Jesús A Cortés-Vecino, Manuel A Patarroyo, Felio J Bello
This study's main objective was to evaluate the action of larval therapy derived from Lucilia sericata and Sarconesiopsis magellanica (blowflies) regarding Leishmania panamensis using an in vivo model. Eighteen golden hamsters (Mesocricetus auratus) were used; they were divided into 6 groups. The first three groups consisted of 4 animals each; these, in turn, were internally distributed into subgroups consisting of 2 hamsters to be used separately in treatments derived from each blowfly species. Group 1 was used in treating leishmanial lesions with larval therapy (LT), whilst the other two groups were used for evaluating the used of larval excretions and secretions (ES) after the ulcers had formed (group 2) and before they appeared (group 3)...
September 26, 2016: Acta Tropica
https://www.readbyqxmd.com/read/27630633/-get-in-early-biofilm-and-wax-moth-galleria-mellonella-models-reveal-new-insights-into-the-therapeutic-potential-of-clostridium-difficile-bacteriophages
#7
Janet Y Nale, Mahananda Chutia, Philippa Carr, Peter T Hickenbotham, Martha R J Clokie
Clostridium difficile infection (CDI) is a global health threat associated with high rates of morbidity and mortality. Conventional antibiotic CDI therapy can result in treatment failure and recurrent infection. C. difficile produces biofilms which contribute to its virulence and impair antimicrobial activity. Some bacteriophages (phages) can penetrate biofilms and thus could be developed to either replace or supplement antibiotics. Here, we determined the impact of a previously optimized 4-phage cocktail on C...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27618619/investigating-the-effect-of-different-treatments-with-lactic-acid-bacteria-on-the-fate-of-listeria-monocytogenes-and-staphylococcus-aureus-infection-in-galleria-mellonella-larvae
#8
Athena Grounta, Paschalis Harizanis, Eleftherios Mylonakis, George-John E Nychas, Efstathios Z Panagou
The use of Galleria mellonella as a model host to elucidate microbial pathogenesis and search for novel drugs and therapies has been well appreciated over the past years. However, the effect of microorganisms with functional appeal in the specific host remains scarce. The present study investigates the effect of treatment with selected lactic acid bacteria (LAB) with probiotic potential, as potential protective agents by using live or heat-killed cells at 6 and 24 h prior to infection with Listeria monocytogenes and Staphylococcus aureus or as potential therapeutic agents by using cell-free supernatants (CFS) after infection with the same pathogens...
2016: PloS One
https://www.readbyqxmd.com/read/27593339/discovery-of-novel-antischistosomal-agents-by-molecular-modeling-approaches
#9
Ana C Mafud, Leonardo G Ferreira, Yvonne P Mascarenhas, Adriano D Andricopulo, Josué de Moraes
Schistosomiasis, a chronic neglected tropical disease caused by Schistosoma worms, is reported in nearly 80 countries. Although the disease affects approximately 260 million people, the treatment relies exclusively on praziquantel, a drug discovered in the mid-1970s that lacks efficacy against the larval stages of the parasite. In addition, the dependence on a single treatment has raised concerns about drug resistance, and reduced susceptibility has already been found in laboratory and field isolates. Therefore, novel therapies for schistosomiasis are needed, and several approaches have been used to that end...
September 1, 2016: Trends in Parasitology
https://www.readbyqxmd.com/read/27567983/anti-leishmania-activity-of-lucilia-sericata-and-calliphora-vicina-maggots-in-laboratory-models
#10
Alireza Sanei-Dehkordi, Ali Khamesipour, Kamran Akbarzadeh, Amir Ahmad Akhavan, Akram Mir Amin Mohammadi, Younes Mohammadi, Yavar Rassi, Mohammad Ali Oshaghi, Zahra Alebrahim, Seyed Ebrahim Eskandari, Javad Rafinejad
Use of sterile fly larvae (maggots) of blow flies for the treatment of many different types of skin and soft tissue wounds is called Maggot debridement therapy (MDT). The larvae of blow flies secrete a broad spectrum of compounds with diverse mechanisms of action in the gut and salivary glands called excretion/secretion (ES) products which showed to have antimicrobial activities against Gram negative and positive bacteria. Cutaneous leishmaniasis (CL) which is the common form of leishmaniasis is difficult to treat...
August 24, 2016: Experimental Parasitology
https://www.readbyqxmd.com/read/27498843/approved-oncology-drugs-lack-in-vivo-activity-against-trichuris-muris-despite-in-vitro-activity
#11
Noemi Cowan, Alessia Raimondo, Jennifer Keiser
Infections with soil-transmitted helminths (STHs) are considered among the most persistent global health problems. The few available drugs have limitations including low efficacy against Trichuris trichiura infections. As a starting point toward drug repositioning, we studied a set of FDA-approved oncology drugs for activity against Trichuris muris since targets relevant to cancer therapy might have a function in helminth biology. Drugs were tested in vitro on the larval and adult stage of T. muris. Compounds active in vitro were tested in the T...
November 2016: Parasitology Research
https://www.readbyqxmd.com/read/27496476/liver-transplantation-for-incurable-alveolar-echinococcosis-an-analysis-of-patients-hospitalized-in-department-of-tropical-and-parasitic-diseases-in-gdynia
#12
M Sulima, W Wołyniec, U Oładakowska-Jedynak, W Patkowski, N Wasielak, K Witczak-Malinowska, S Borys, W Nahorski, A Wroczyńska, B Szostakowska, A Lass, M Krawczyk
INTRODUCTION: Alveolar echinococcosis is a parasitic disease caused by the larval stage of tapeworm Echinococcus multilocularis. It usually involves the liver, but can spread to other organs. The treatment of choice is a surgical resection supported by antiparasitic drugs. In the advanced stages of the disease a liver transplantation is the only option. AIM: This article presents the problems related to care of patients after liver transplantation for advanced alveolar echinococcosis...
June 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27390689/safety-effectiveness-and-economic-aspects-of-maggot-debridement-therapy-for-wound-healing
#13
Jalal Arabloo, Serajaddin Grey, Mohammadreza Mobinizadeh, Alireza Olyaeemanesh, Pejman Hamouzadeh, Kiumars Khamisabadi
BACKGROUND: Maggot therapy has recently attracted considerable attention as an emerging debridement technique for wound healing. This study aimed to review the safety, effectiveness and economic evaluations of Maggot Debridement Therapy for wound healing. METHODS: To retrieve the relevant evidences, the Cochrane Library (until September 2014) was searched by appropriate keywords, using free text and Mesh. Systematic reviews, HTA reports and economic evaluation studies that compared larval therapy with other debridement therapies, such as hydrogel in patients with various kinds of ulcers in terms of side effects, the wound healing rate, the healing time, and cost per QALY, were included...
2016: Medical Journal of the Islamic Republic of Iran
https://www.readbyqxmd.com/read/27387914/updates-on-feline-aelurostrongylosis-and-research-priorities-for-the-next-decade
#14
REVIEW
Hany M Elsheikha, Manuela Schnyder, Donato Traversa, Angela Di Cesare, Ian Wright, David W Lacher
Feline aelurostrongylosis, caused by the metastrongyloid nematode Aelurostrongylus abstrusus, is an important gastropod-borne parasitic lung disease in cats. Infection with A. abstrusus is widespread globally, but the increasing awareness of this parasite and the advent of more sensitive diagnostics have contributed to the apparent increase in its prevalence and geographic expansion. Clinical features may range in severity from subclinical to life-threatening respiratory disease. Parasitological standard techniques, such as visualization of the nematode first larval stage in faecal and respiratory (bronchial mucus or pleural fluid) samples, remain the mainstays of diagnosis...
2016: Parasites & Vectors
https://www.readbyqxmd.com/read/27165358/allograft-cancer-cell-transplantation-in-zebrafish
#15
REVIEW
John C Moore, David M Langenau
Allogeneic cell transplantation is the transfer of cells from one individual into another of the same species and has become an indispensable technique for studying development, immunology, regeneration and cancer biology. In experimental settings, tumor cell engraftment into immunologically competent recipients has greatly increased our understanding of the mechanisms that drive self-renewal, progression and metastasis in vivo. Zebrafish have quickly emerged as a powerful genetic model of cancer that has benefited greatly from allogeneic transplantation...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27094514/in-vivo-efficacy-of-trans-cinnamaldehyde-carvacrol-and-thymol-in-attenuating-listeria-monocytogenes-infection-in-a-galleria-mellonella-model
#16
Abhinav Upadhyay, Kumar Venkitanarayanan
Listeria monocytogenes is a major foodborne pathogen that causes life-threatening illnesses in humans. With emergence of antibiotic resistance in L. monocytogenes, there is considerable interest in testing the efficacy of alternative therapies for controlling listeriosis in humans. This study investigated the efficacy of three phytochemicals, namely trans-cinnamaldehyde (TC), carvacrol (CR), and thymol (TY) in reducing L. monocytogenes virulence in the recently established invertebrate model, Galleria mellonella...
July 2016: Journal of Natural Medicines
https://www.readbyqxmd.com/read/27065807/natural-bizbenzoquinoline-derivatives-protect-zebrafish-lateral-line-sensory-hair-cells-from-aminoglycoside-toxicity
#17
Matthew Kruger, Robert Boney, Alexander J Ordoobadi, Thomas F Sommers, Josef G Trapani, Allison B Coffin
Moderate to severe hearing loss affects 360 million people worldwide and most often results from damage to sensory hair cells. Hair cell damage can result from aging, genetic mutations, excess noise exposure, and certain medications including aminoglycoside antibiotics. Aminoglycosides are effective at treating infections associated with cystic fibrosis and other life-threatening conditions such as sepsis, but cause hearing loss in 20-30% of patients. It is therefore imperative to develop new therapies to combat hearing loss and allow safe use of these potent antibiotics...
2016: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/27051107/cystic-pulmonary-hydatidosis
#18
REVIEW
Malay Sarkar, Rajnish Pathania, Anupam Jhobta, Babu Ram Thakur, Rajesh Chopra
Cystic echinococcosis (CE) is a zoonotic parasitic disease caused by the larval stages of the cestode Echinococcus granulosus. Worldwide, pulmonary hydatid cyst is a significant problem medically, socially, and economically. Surgery is the definitive therapy of pulmonary hydatidosis. Benzimidazoles may be considered in patients with a surgical contraindication. This review will focus on pathogenesis, lifecycle, clinical features, and management of pulmonary hydatid disease.
March 2016: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/27041484/methods-for-external-disinfection-of-blow-fly-diptera-calliphoridae-eggs-prior-to-use-in-wound-debridement-therapy
#19
Adrienne L Brundage, Tawni L Crippen, Jeffery K Tomberlin
Maggot debridement therapy (MDT) is the use of the larval stage of flies (i.e., Calliphoridae) to remove necrotic tissue and disinfect wounds. Effective MDT requires aseptic technique to prevent the unintentional introduction of pathogenic bacteria into a wound to be debrided; yet the external surface of Calliphoridae eggs is often heavily contaminated with bacteria. Studies of external disinfection of dipteran eggs have been reported, but neither their efficacy nor effect on egg viability has been adequately assessed...
March 2016: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/27035978/paclitaxel-induced-epithelial-damage-and-ectopic-mmp-13-expression-promotes-neurotoxicity-in-zebrafish
#20
Thomas S Lisse, Leah J Middleton, Adriana D Pellegrini, Paige B Martin, Emily L Spaulding, Olivia Lopes, Elizabeth A Brochu, Erin V Carter, Ashley Waldron, Sandra Rieger
Paclitaxel is a microtubule-stabilizing chemotherapeutic agent that is widely used in cancer treatment and in a number of curative and palliative regimens. Despite its beneficial effects on cancer, paclitaxel also damages healthy tissues, most prominently the peripheral sensory nervous system. The mechanisms leading to paclitaxel-induced peripheral neuropathy remain elusive, and therapies that prevent or alleviate this condition are not available. We established a zebrafish in vivo model to study the underlying mechanisms and to identify pharmacological agents that may be developed into therapeutics...
April 12, 2016: Proceedings of the National Academy of Sciences of the United States of America
keyword
keyword
75536
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"