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https://www.readbyqxmd.com/read/28636252/influence-of-analyzed-lubricant-volumes-on-the-amount-and-characteristics-of-generated-wear-particles-from-three-different-types-of-polyethylene-liner-materials
#1
Jana Markhoff, Carmen Zietz, Christian Fabry, Gerhard Fulda, Rainer Bader
The articulating components of artificial joints consist mainly of metals, ceramics, or polymers. Resulting abrasive wear particles can promote osteolysis and aseptic loosening of the endo-prosthetic implants. Ultra-high-molecular-weight-polyethylene is the material used most for bearing couples in total hip replacement. In the present study, three types of polyethylene (PE) liners varying in material composition, i.e., (1) conventional PE (C-PE), (2) sequentially cross-linked PE (SX-PE), (3) cross-linked PE blended with vitamin E (EX-PE) articulating with two types of femoral heads were used...
June 21, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28630834/van-neck-odelberg-disease-a-rare-case-report
#2
Amit Prakash Chaudhari, Gautam Shah, Sameer Sanjeev Patil, Aashish Babanrao Ghodke, Sagar B Kelkar
INTRODUCTION: Pain in groin without any history of trauma or positive clinical findings of infection or stress fracture in ischiopubic ramus poses challenges in diagnosis of the condition in prepubertal age. "Osteochondrosis of ischiopubic synchondrosis (IPS)" also called as "Van Neck-Odelberg" disease. Left leg dominant patient presented with pain in groin and limping with left leg dominance. Differential diagnosis - such as stress fractures, osteomyelitis, tuberculosis, post-traumatic osteolysis, or any neoplasia - is need be ruled out to arrive at diagnosis...
January 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28617442/titanium-particle-induced-osteogenic-inhibition-and-bone-destruction-are-mediated-by-the-gsk-3%C3%AE-%C3%AE-catenin-signal-pathway
#3
Ye Gu, Zhirong Wang, Jiawei Shi, Liangliang Wang, Zhenyang Hou, Xiaobin Guo, Yunxia Tao, Xiexing Wu, Wei Zhou, Yu Liu, Wen Zhang, Yaozeng Xu, Huilin Yang, Feng Xue, Dechun Geng
Wear debris-induced osteogenic inhibition and bone destruction are critical in the initiation of peri-prosthetic osteolysis. However, the molecular mechanism underlying this phenomenon is poorly understood. In this study, we analyzed the involvement of the GSK-3β/β-catenin signal pathway, which is important for bone formation in this pathological condition. We established a titanium (Ti) particle-stressed murine MC3T3-E1 cell culture system and calvariae osteolysis model to test the hypothesis that Ti particle-induced osteogenic inhibition and bone destruction are mediated by the GSK-3β/β-catenin signal pathway...
June 15, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28611279/selective-inhibition-of-matrix-metalloproteinase-2-in-the-multiple-myeloma-bone-microenvironment
#4
Gemma Shay, Marilena Tauro, Fulvio Loiodice, Paolo Tortorella, Daniel M Sullivan, Lori A Hazlehurst, Conor C Lynch
Multiple myeloma is a plasma cell malignancy that homes aberrantly to bone causing extensive skeletal destruction. Despite the development of novel therapeutic agents that have significantly improved overall survival, multiple myeloma remains an incurable disease. Matrix metalloproteinase-2 (MMP-2) is associated with cancer and is significantly overexpressed in the bone marrow of myeloma patients. These data provide rationale for selectively inhibiting MMP-2 activity as a multiple myeloma treatment strategy...
May 23, 2017: Oncotarget
https://www.readbyqxmd.com/read/28606638/retrospective-cohort-study-on-radial-head-replacements-comparing-results-between-smooth-and-porous-stem-designs
#5
Mélissa Laflamme, Pierre-Philippe Grenier-Gauthier, Alexandre Leclerc, Stéphanie Antoniades, Anne-Marie Bédard
BACKGROUND: When necessary, radial head integrity after a fracture can be re-created by the use of a radial head arthroplasty if the radial head is judged irreparable. The purpose of this study was to compare the clinical and radiographic outcomes of metal modular radial head replacements with a smooth vs. a porous stem. METHODS: A retrospective cohort study of radial head replacements performed in the first 4 weeks after a trauma in an adult patient at our institution between 2000 and 2014 was completed...
June 9, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28593060/fracture-of-the-tibial-baseplate-16-years-after-miller-galante-ii-total-knee-arthroplasty
#6
Kazuaki Mineta, Masahiko Okada, Soshi Matsumoto, Daisuke Hamada, Tomohiro Goto, Koichi Sairyo
We report a rare case of tibial baseplate fracture of Miller-Galante II (MG II) prosthesis. We examine the factors that may cause such late fracture and review the literature on radiographic analysis and retrieval studies. A 76-year-old woman, who had undergone bilateral MG II total knee arthroplasty due to rheumatoid arthritis 16 years earlier, presented to our department with a 3-month history of left knee pain. Plain radiographs revealed severe distortion of the medial tibial component. During revision knee arthroplasty, we observed severe metallosis in the knee joint, polyethylene insert deformation, and posteromedial coronal baseplate fracture...
2017: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/28587888/outcome-of-4-surgical-treatments-for-wear-and-osteolysis-of-cementless-acetabular-components
#7
Rapeepat Narkbunnam, Derek F Amanatullah, Ali J Electriwala, James I Huddleston, William J Maloney, Stuart B Goodman
BACKGROUND: Loosening and periprosthetic osteolysis are some of the most common long-term complications after hip arthroplasty. The decision-making process and surgical treatment options are controversial. METHODS: We retrospectively reviewed 96 acetabular revisions (91 patients) performed between 2002 and 2012, with a minimum of 2 years of follow-up and a mean of 5.7 years of follow-up. Clinical outcome was assessed using the Harris Hip Score. The size and location of osteolytic lesions were evaluated using the preoperative radiographs; healing of the defects was categorized using a standardized protocol...
April 27, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28583775/-a-lumbar-vertebral-eosinophilic-granuloma-with-spinal-instability-in-an-adolescent
#8
K Bin, S Jacopin, E Poinsot, C Stoven, J-C Ruzic, S Maurin, E Enaud
This is a case report of a rare isolated eosinophilic granuloma of vertebra L3, in a 15-year-old adolescent. Vertebral instability, due to aggravation of the osteolysis, occurred without neurological symptoms despite orthopedic treatment. Surgery was necessary to correct and stabilize the spinal deformation. Postoperative chemotherapy (vinblastine and corticoids) was given as recommended for Langerhans cell histiocytosis (HL2010). No recurrence was observed after 5 years of follow-up.
June 2, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28579445/clinical-and-radiographic-outcomes-of-total-hip-arthroplasty-with-a-specific-liner-in-small-asian-patients-influence-of-patient-related-implant-related-and-surgical-factors-on-femoral-head-penetration
#9
Hirofumi Oshima, Sakae Tanaka, Yoshio Takatori, Takeyuki Tanaka, Hisatoshi Ishikura, Toru Moro
BACKGROUND: We evaluated the clinical and radiographic outcomes, including femoral head penetration, of total hip arthroplasty performed using a specific polyethylene (PE) liner in small Asian patients at 10 years after the index surgery. In addition, we investigated whether femoral head penetration was affected by patient-related, implant-related, and surgical factors. METHODS: Between August 2002 and June 2005, for cementless primary total hip arthroplasty, we used acetabular PE liners that were manufactured from GUR 1050 resin, machined from isostatic compression-molded bar stock, and sterilized with a gamma ray irradiation in argon gas...
May 4, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28578796/are-periprosthetic-osteolytic-lesions-in-ankle-worth-bone-grafting
#10
Ia Kohonen, Helka Koivu, Hannu Tiusanen, Jussi Kankare, Tero Vahlberg, Kimmo Mattila
BACKGROUND: We retrospectively evaluated the medium-term follow-up of bone grafting due to periprosthetic osteolytic lesions in ankles. METHODS: 34 ankles (32 patients) with total ankle arthroplasty (TAA) underwent re operation. Indications were large periprosthetic osteolytic lesions or continuous growing of the lesions. The osteolytic lesions were imaged by CT before reoperation and once a year after that. The mean CT follow-up after re operation was 3.8 years (range, 2-6...
June 2017: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28578793/medium-to-long-term-results-of-130-ankle-evolutive-system-total-ankle-replacements-inferior-survival-due-to-peri-implant-osteolysis
#11
Helka Koivu, Ia Kohonen, Kimmo Mattila, Eliisa Loyttyniemi, Hannu Tiusanen
BACKGROUND: The study reports the medium to long-term results of 130 Ankle Evolutive System total ankle replacements operated at a single-centre. Previously high amount of peri-implant osteolysis was reported from the same material. METHODS: Between 2002 and 2008 one hundred and thirty consecutive ankles replaced with AES ankle prosthesis were followed both radiologically and clinically. RESULTS: The five-year survival was 87.3% (95% confidence interval (CI) 80...
June 2017: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28574118/wear-of-xlpe-liner-against-zirconium-heads-in-cementless-total-hip-arthroplasty-for-patients-under-40-years-of-age
#12
Motoki Sonohata, Masaru Kitajima, Shunsuke Kawano, Masaaki Mawatari
INTRODUCTION: Total hip arthroplasty (THA) in the young is challenging. The purpose of this study was to retrospectively determine the clinical, radiographic, and polyethylene wear rate of relatively young patients. METHODS: We evaluated the outcome of consecutive patients receiving primary THA who were under 40 years of age with a minimum 10-year follow-up. Indications for THA in these patients were osteoarthritis due to developmental dysplasia of the hip joint (9 hips), osteonecrosis of the femoral head (7 hips), juvenile idiopathic arthritis (2 hips), and osteoarthritis due to Perthes disease (1 hip)...
May 27, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/28571805/gallium-and-silicon-synergistically-promote-osseointegration-of-dental-implant-in-patients-with-osteoporosis
#13
Jinsong Liu, Zuosu Wu, Hongli He, Kaiyong Cai, Hualin Zhang, Lihua Xu
Over the last few decades, a wide variety of dental implants have been successfully placed in jaw bones to restore tooth function. But major challenges still remain in patients with osteoporosis involving compromised osseointegration, and the therapeutic methods is far from optimism. Gallium can directly inhibit bone osteolysis, prevent bone calcium release and augment bone mass, which makes Ga unique among the potential antiresorptive drugs. Silicon, as an indispensable modulator in bone formation, presents its bone anabolic effects, while reduces, at least doesn't increase, bone resorption...
June 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28570216/thirteen-year-wear-rate-comparison-of-highly-crosslinked-and-conventional-polyethylene-in-total-hip-arthroplasty-long-term-follow-up-of-a-prospective-randomized-controlled-trial
#14
Matthew G Teeter, Xunhua Yuan, Lyndsay E Somerville, Steven J MacDonald, Richard W McCalden, Douglas D Naudie
BACKGROUND: The purpose of this study was to report the radiographic wear rates from a previous randomized controlled trial of first-generation highly crosslinked versus conventional polyethylene in total hip arthroplasty (THA) at a minimum of 13 years' follow-up. METHODS: Patients returned for radiographic imaging and radiostereometric analysis (RSA). Radiographs were reviewed for the presence of osteolysis or component loosening. Femoral head penetration (which includes both wear and creep) was measured using RSA...
June 2017: Canadian Journal of Surgery. Journal Canadien de Chirurgie
https://www.readbyqxmd.com/read/28569732/inflammatory-osteolysis-a-conspiracy-against-bone
#15
REVIEW
Gabriel Mbalaviele, Deborah V Novack, Georg Schett, Steven L Teitelbaum
There are many causes of inflammatory osteolysis, but regardless of etiology and cellular contexts, the osteoclast is the bone-degrading cell. Thus, the impact of inflammatory cytokines on osteoclast formation and function was among the most important discoveries advancing the treatment of focal osteolysis, leading to development of therapeutic agents that either directly block the bone-resorptive cell or do so indirectly via cytokine arrest. Despite these advances, a substantial number of patients with inflammatory arthritis remain resistant to current therapies, and even effective anti-inflammatory drugs frequently do not repair damaged bone...
June 1, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28566392/mid-term-results-of-the-biolox-delta-ceramic-on-ceramic-total-hip-arthroplasty
#16
Y K Lee, Y C Ha, J-I Yoo, W L Jo, K-C Kim, K H Koo
AIMS: We conducted a prospective study of a delta ceramic total hip arthroplasty (THA) to determine the rate of ceramic fracture, to characterise post-operative noise, and to evaluate the mid-term results and survivorship. PATIENTS AND METHODS: Between March 2009 and March 2011, 274 patients (310 hips) underwent cementless THA using a delta ceramic femoral head and liner. At each follow-up, clinical and radiological outcomes were recorded. A Kaplan-Meier analysis was undertaken to estimate survival...
June 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/28557297/correlation-of-cup-inclination-angle-with-liner-wear-for-metal-on-polyethylene-in-hip-primary-arthroplasty
#17
Jia-Liang Tian, Li Sun, Rui-Yin Hu, Wei Han, Xiao-Bin Tian
OBJECTIVES: The relationship between cup inclination angle and liner wear is controversial. Most authors in the published literature agree that the ideal cup inclination is associated with lower inner wear; however, some disagree. All previous studies did not control for femoral head diameter and inclination, so it is difficult to assess the relative or synergistic effects of cup angle on outcomes. METHODS: We retrospectively reviewed 154 patients (171 hips) with primary total hip arthroplasties performed from 2001 to 2004...
May 2017: Orthopaedic Surgery
https://www.readbyqxmd.com/read/28554796/detection-of-bone-defects-around-zirconium-component-after-total-knee-arthroplasty
#18
Yukihide Minoda, Kazumasa Yamamura, Kazutaka Sugimoto, Shigekazu Mizokawa, Shingo Baba, Hiroaki Nakamura
BACKGROUND: It is difficult to detect bone defects caused by loosening or osteolysis around the femoral component after total knee arthroplasty (TKA) because the thick metal hinders visualization of bone defects. Previous reports have shown that tomosynthesis, a novel tomographic technique, is advantageous over fluoroscopically guided plain radiography, computed tomography (CT) and magnetic resonance imaging (MRI) for the early detection of bone defects around a conventional cobalt-chromium alloy component...
May 26, 2017: Knee
https://www.readbyqxmd.com/read/28553448/multicentric-disappearing-bone-disease-treated-with-arthroplasty
#19
C K Chan, Razif-Ma Mohamed, A A Azlina, M M Azhar
Multicentric disappearing bone disease, or Gorham disease, is a rare entity. A middle age woman, presented to us with left sided antalgic gait and severe bony deformity of her left knee. Radiograph revealed massive bone defect of the medial condyle of the left tibia with subluxation of the knee joint. She was scheduled for knee replacement in six months. However, she developed another lesion over the right hip that typically mimicked the disease progression of disappearing bone disease. The right femoral head vanished progressively within three months without significant history of infection or trauma...
November 2016: Malaysian Orthopaedic Journal
https://www.readbyqxmd.com/read/28553103/the-metal-nanoparticle-induced-inflammatory-response-is-regulated-by-sirt1-through-nf-%C3%AE%C2%BAb-deacetylation-in-aseptic-loosening
#20
Zhantao Deng, Jiewen Jin, Zhenheng Wang, Yong Wang, Qian Gao, Jianning Zhao
Aseptic loosening is the most common cause of total hip arthroplasty (THA) failure, and osteolysis induced by wear particles plays a major role in aseptic loosening. Various pathways in multiple cell types contribute to the pathogenesis of osteolysis, but the role of Sirtuin 1 (SIRT1), which can regulate inflammatory responses through its deacetylation, has never been investigated. We hypothesized that the downregulation of SIRT1 in macrophages induced by metal nanoparticles was one of the reasons for osteolysis in THA failure...
2017: International Journal of Nanomedicine
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