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Osteolysis

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https://www.readbyqxmd.com/read/28426756/excessive-dietary-intake-of-vitamin-a-reduces-skull-bone-thickness-in-mice
#1
Thomas Lind, Caroline Öhman, Gabriela Calounova, Annica Rasmusson, Göran Andersson, Gunnar Pejler, Håkan Melhus
Calvarial thinning and skull bone defects have been reported in infants with hypervitaminosis A. These findings have also been described in humans, mice and zebrafish with loss-of-function mutations in the enzyme CYP26B1 that degrades retinoic acid (RA), the active metabolite of vitamin A, indicating that these effects are indeed caused by too high levels of vitamin A and that evolutionary conserved mechanisms are involved. To explore these mechanisms, we have fed young mice excessive doses of vitamin A for one week and then analyzed the skull bones using micro computed tomography, histomorphometry, histology and immunohistochemistry...
2017: PloS One
https://www.readbyqxmd.com/read/28419886/total-hip-arthroplasty-for-patients-with-crowe-type-iv-developmental-dysplasia-of-the-hip-ten-years-results
#2
Wei-Nan Zeng, Jun-Li Liu, Fu-You Wang, Xin Zhang, Hua-Quan Fan, Guang-Xing Chen, Lin Guo, Xiao-Jun Duan, Qiang Zhou, Liu Yang
BACKGROUND AND OBJECTIVES: The aim of this study was to determine the rate of union, functional results and complications in patients with Crowe IV developmental dysplasia of the hip (DDH) who underwent cementless total hip arthroplasty (THA) with S-ROM prostheses and subtrochanteric transverse shortening osteotomy. METHODS: Forty-five patients (52 hips) operated between January 2005 and May 2008, with a mean age of 40.6 years at surgery were followed. The mean follow-up period was 9...
April 15, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28418093/hypoxia-inducible-factor-1-alpha-does-not-regulate-osteoclastogenesis-but-enhances-bone-resorption-activity-via-prolyl-4-hydroxylase-2
#3
Philippa A Hulley, Tammie Bishop, Aude Vernet, Jurgen E Schneider, James R Edwards, Nick A Athanasou, Helen J Knowles
Osteogenic-angiogenic coupling is promoted by the Hypoxia-Inducible Factor 1-alpha (HIF-1α) transcription factor, provoking interest in HIF activation as a therapeutic strategy to improve osteoblast mineralisation and treat pathological osteolysis. However, HIF also enhances the bone resorbing activity of mature osteoclasts. It is therefore essential to determine the full effect(s) of HIF on both the formation and bone-resorbing function of osteoclasts in order to understand how they might respond to such a strategy...
April 18, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/28411135/silent-sinus-syndrome%C3%A2-a-traumatic-case
#4
E Février, C Vandersteen, L Castillo, C Savoldelli
INTRODUCTION: Silent sinus syndrome is an unusual cause of progressive enophthalmos and hypoglobus due to atelectasia of the maxillary sinus associated with osteolysis of the orbital floor. This syndrome is classically idiopathic, but the term is also used to describe traumatic or iatrogenic (surgical orbital decompression) cases. CASE REPORT: We report the case of a 33-year-old man who presented with a left orbital trauma without functional disorder. Computed tomography (CT) scan revealed a nondisplaced fracture of the left orbital floor...
April 11, 2017: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28408260/evaluation-of-bioabsorbable-multiamino-acid-copolymer-nano-hydroxyapatite-calcium-sulphate-cage-in-a-goat-spine-model
#5
Chunpeng Ren, Yueming Song, Youdi Xue, Xi Yang, Chunguang Zhou
BACKGROUND: Recently, polylactide is the most popular material used to made bioabsorbable cages, but too fast degradation and osteolysis around the cage have been reported in the literature. This study evaluated the fusion effect, biomechanical stability and histological characteristics of a novel bioabsorbable multi-amino acid copolymer/nano-hydroxyapatite/calcium sulphate (MAACP/n-HA/CS) interbody cage in a goat model of anterior cervical discectomy and fusion (ACDF). METHODS: A total of 24 goats underwent C3/C4 discectomy and fusion with three groups of intervertebral implants: MAACP/n-HA/CS cage group (n = 8), titanium cage group (n = 8) and autologous tricortical iliac crest bone group (n = 8)...
April 10, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28400670/gorham-s-disease-in-humerus-treated-with-autogenous-vascularized-fibular-graft
#6
Jeung Woo Kim, Hong Je Kang, Dong Chul Kim, Chang Hyun Shin
Gorham's disease is a rare disorder of the bone characterized by progressive massive osteolysis. The pathophysiology is unknown, and diagnosis is often difficult. Most cases are often recognized retrospectively. There is no standardized treatment and management for Gorham's disease. We report a case of an 18-year-old male presenting with a pathologic fracture in the humerus shaft diagnosed with Gorham's disease. Patient was treated with autogenous vascularized fibular graft with wide excision and a 10 years followup after first surgery...
March 2017: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/28395945/radiographic-changes-and-clinical-outcomes-associated-with-an-adjustable-diaphyseal-press-fit-humeral-stem-in-primary-reverse-shoulder-arthroplasty
#7
Samuel M Harmsen, Tom R Norris
BACKGROUND: Press-fit humeral fixation in reverse shoulder arthroplasty (RSA) has become increasingly popular; however, radiographic analysis of these stems is limited. We aimed to evaluate the radiographic and clinical outcomes of an adjustable diaphyseal press-fit humeral stem in primary RSA. METHODS: We conducted a retrospective review of 232 primary RSAs in 219 patients performed by a single surgeon using this system. Radiographic outcomes were evaluated in patients with at least 2 years of radiographic follow-up...
April 7, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28392135/ten-year-cross-sectional-study-of-mechanically-assisted-crevice-corrosion-in-1352-consecutive-patients-with-metal-on-polyethylene-total-hip-arthroplasty
#8
Daniel K Hussey, Brian J McGrory
BACKGROUND: Mechanically assisted crevice corrosion (MACC) in metal-on-polyethylene total hip arthroplasty (THA) is of concern, but its prevalence, etiology, and natural history are incompletely understood. METHODS: From January 2003 to December 2012, 1352 consecutive THA surgeries using a titanium stem, cobalt-chromium alloy femoral head, and highly cross-linked polyethylene liner from a single manufacturer were performed. Patients were followed at 1-year and 5-year intervals for surveillance, but also seen earlier if they had symptoms...
March 18, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28384949/comparative-study-of-surgical-management-of-fracture-neck-of-femur-with-cemented-versus-uncemented-bipolar-hemiarthroplasty
#9
Y S Prashanth, M Niranjan
INTRODUCTION: There is evidence for use of cemented hemiarthroplasty resulting in greater anchoring and lesser peri prosthetic fracture. However, this procedure results in more haemodynamic instability and cardiopulmonary complications termed as 'cement reaction' or bone cement implantation syndrome. There has been a heightened interest among surgeons to compare cemented and uncemented hemiarthroplasty for fracture neck of femur. AIM: To compare cemented and uncemented hemiarthroplasty in terms of blood loss during the procedure, post-operative complications, mortality, functional recovery and long term clinical outcome...
February 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28384557/from-tooth-extraction-to-gorham-stout-disease-a-case-report
#10
Gabriele Bocchialini, Luca Ferrari, Dante Burlini
INTRODUCTION: Gorham-Stout disease (GSD), or vanishing bone disease, is a very rare condition of unknown aetiology. It is characterised by progressive osteolysis and angiomatosis. CASE PRESENTATION: We report the discovery of this very rare disease following a trivial deciduous tooth extraction in a 14-year-old female. We focus initially on the difference between the preoperative orthopantomography and the whole-body computed tomography and magnetic resonance images obtained post-haemorrhage, and then on the improvement of strategies for the correct diagnosis and treatment of this disease...
March 21, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28384530/notoginsenoside-r1-suppresses-wear-particle-induced-osteolysis-and-rankl-mediated-osteoclastogenesis-in-vivo-and-in-vitro
#11
Shuai Zhao, Lianqi Yan, Xiaolei Li, Zhen Zhang, Yu Sun, Jingcheng Wang
Aseptic periprosthetic osteolysis is a complication induced by wear particles after hip joint replacement, which shortens the service life of prostheses. Although many methods have been applied to prevent this complication, the results were not always successful. In the present study, we explored the prophylactic effect of notoginsenoside R1 (NG-R1) on a Ti particle-induced mouse calvarial osteolysis model and the inhibitory effect on RANKL-mediated osteoclastogenesis and osteoclast bone resorption. Our results indicated that intraperitoneal injection of NG-R1(10 or 20mg/kg/day), a constituent of notoginseng, alleviates Ti particle-induced mouse calvarial osteolysis after twelve days post-treatment...
April 3, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28382864/microrna-130b-promotes-wear-particle-induced-osteolysis-via-downregulating-frizzled-related-protein-frzb
#12
De-Zhi Zheng, Yan-Min Bu, Lei Wang, Jun Liu
Periprosthetic osteolysis induced by wear particles can lead to aseptic loosening, one main reason of arthroplasty failure. However, the role of microRNA-130b (miR-130b) in particle-induced osteolysis (PIO) has not been explored yet. In this study, PIO models were established in C57BL/J6 mice via the implantation of Co-Cr-Mo alloy particles, and evaluated by detecting tartrate-resistant acid phosphatase (TRAP) activity and bone resorption in the calvaria. Mouse preosteoblast MC3T3-E1 cells were cultured to receive particle stimulation in vitro...
2017: Current Neurovascular Research
https://www.readbyqxmd.com/read/28382716/identical-presentation-of-scapular-osteolysis-in-two-patients-with-thoracic-kaposiform-hemangioendothelioma
#13
Verónica Alonso Arroyo, Juan Carlos Lopez-Gutierrez, Rox Martinez, Israel Fernandez-Pineda
Kaposiform hemangioendothelioma (KHE) is a rare, locally aggressive vascular tumor that does not metastasize. We report two unique cases of KHE involving the right hemithorax and the upper ipsilateral extremity. Kasabach-Merrit phenomenon and osteolytic lesions in the scapula were observed in both cases.
April 6, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28375892/metal-artifact-reduction-sequence-mri-abnormalities-in-asymptomatic-patients-with-a-ceramic-on-polyethylene-total-hip-replacement
#14
Jason M Jennings, J Ryan Martin, Raymond H Kim, Charlie C Yang, Todd M Miner, Douglas A Dennis
BACKGROUND: Magnetic resonance imaging (MRI) is a commonly utilized screening modality in patients with a metal-on-metal (MoM) total hip replacement. The prevalence of clinically important fluid collections may be overestimated since these collections have been reported to occur in asymptomatic patients with MoM and other bearing surfaces. The purpose of this study was to determine the frequency and types of MRI-documented adverse local tissue reactions in asymptomatic patients with a ceramic-on-polyethylene (CoP) total hip replacement...
April 5, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28375671/outcome-in-design-specific-comparisons-between-highly-crosslinked-and-conventional-polyethylene-in-total-hip-arthroplasty
#15
Per-Erik Johanson, Ove Furnes, Leif Ivar Havelin, Anne Marie Fenstad, Alma B Pedersen, Søren Overgaard, Göran Garellick, Keijo Mäkelä, Johan Kärrholm
Background and purpose - Most registry studies regarding highly crosslinked polyethylene (XLPE) have focused on the overall revision risk. We compared the risk of cup and/or liner revision for specific cup and liner designs made of either XLPE or conventional polyethylene (CPE), regarding revision for any reason and revision due to aseptic loosening and/or osteolysis. Patients and methods - Using the Nordic Arthroplasty Register Association (NARA) database, we identified cup and liner designs where either XLPE or CPE had been used in more than 500 THAs performed for primary hip osteoarthritis...
April 4, 2017: Acta Orthopaedica
https://www.readbyqxmd.com/read/28368420/matrix-metalloproteinase-processing-of-pthrp-yields-a-selective-regulator-of-osteogenesis-pthrp1-17
#16
J S Frieling, G Shay, V Izumi, S T Aherne, R G Saul, M Budzevich, J Koomen, C C Lynch
Parathyroid hormone-related protein (PTHrP) is a critical regulator of bone resorption and augments osteolysis in skeletal malignancies. Here we report that the mature PTHrP1-36 hormone is processed by matrix metalloproteinases to yield a stable product, PTHrP1-17. PTHrP1-17 retains the ability to signal through PTH1R to induce calcium flux and ERK phosphorylation but not cyclic AMP production or CREB phosphorylation. Notably, PTHrP1-17 promotes osteoblast migration and mineralization in vitro, and systemic administration of PTHrP1-17 augments ectopic bone formation in vivo...
April 3, 2017: Oncogene
https://www.readbyqxmd.com/read/28367856/successful-management-of-gorham-stout-disease-in-the-cervical-spine-by-combined-conservative-and-surgical-treatments-a-case-report
#17
Satoshi Tateda, Toshimi Aizawa, Ko Hashimoto, Haruo Kanno, Susumu Ohtsu, Eiji Itoi, Hiroshi Ozawa
Gorham-Stout disease (GSD) is a rare condition characterized by intraosseous proliferation of endothelial-lined vessels and progressive osteolysis. The precise etiology and pathophysiology of the disease remain poorly understood. Current therapeutic options for GSD include chemotherapy, radiotherapy, and surgical resection, but the surgical treatment of GSD is difficult, especially in the spinal lesion. The indication of wide-margined resection was limited because of anatomical features. Herein, we report a case of GSD of the cervical spine in which the lesions were successfully stabilized with combined conservative and surgical treatments...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28367690/histological-analysis-of-early-osteolysis-in-total-ankle-arthroplasty
#18
Oliver N Schipper, Steven L Haddad, Peter Pytel, Ying Zhou
BACKGROUND: The purpose of this study was to perform a histological comparative analysis of tibiotalar joint samples taken from areas of osteolysis adjacent to total ankle arthroplasties vs control synovial specimens to determine the reaction to and presence of polyethylene (PE) particles. METHODS: A total of 57 pathology samples were identified in the osteolysis group, while 11 were identified in the control group. For each sample, hematoxylin and eosin, Oil Red O (ORO), and macrophage marker CD163-stained slides were created...
April 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28366313/short-to-midterm-outcomes-of-revision-total-knee-arthroplasty-patients-with-a-total-stabilizer-knee-system
#19
Chukwuweike U Gwam, Morad Chughtai, Anton Khlopas, Nequesha Mohamed, Randa K Elmallah, Arthur L Malkani, Michael A Mont
BACKGROUND: Revision total knee arthroplasty (TKA) can often be challenging. The use of a new revision system may aid in providing better stability, improved function, fit, and implant longevity. Therefore, we assessed: (1) survivorship, (2) clinical outcomes, (3) postoperative complications, and (4) radiographic outcomes of patients who underwent revision TKA using this system. METHODS: Patients from 2 hospitals who underwent revision TKA using a newer generation revision knee system between June 2008 and December 2013 for component instability or aseptic loosening were included...
March 2, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28352284/radiographic-findings-in-patients-with-medication-related-osteonecrosis-of-the-jaw
#20
Camila Lopes Cardoso, Carolina Arrabal Barros, Cláudia Curra, Luciana Maria Paes da Silva Ramos Fernandes, Solange de Oliveira Braga Franzolin, Joel Santiago Ferreira Júnior, Carlos César De Antoni, Marcos Martins Curi
A retrospective study was conducted of the records and panoramic radiographs of 35 patients treated with bisphosphonates (BP) and diagnosed with MRONJ. Panoramic radiography was used for evaluation, by two examiners, the following findings were subject of search: osteolysis (OT), cortical bone erosion (EC), bone sclerosis focal (FS) and diffuse (DS), bone sequestration (BS), thickening of lamina dura (TD), prominence of the inferior alveolar nerve canal (IAN), persisting alveolar sockets (SK), and the presence of a pathological fracture (PF)...
2017: International Journal of Dentistry
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