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https://www.readbyqxmd.com/read/28229166/-morphological-investigations-of-deep-sole-ulcers-in-cattle-part-2-toe-ulcers-white-line-disease-in-the-heel-and-changes-due-to-inappropriate-weight-bearing-and-deficient-claw-care
#1
Susanne Gehringer, Matthias Müller, Johann Maierl
OBJECTIVE: To demonstrate the morphology of pathological changes to the inner structures of the claw in cases of toe ulcers, white line disease in the heel and changes due to inappropriate weight bearing and deficient claw care. MATERIAL AND METHODS: Hind limbs of 55 cows displaying external signs of complicated sole ulcers were examined externally and internally. To examine the samples internally, a sagittal section was performed. Furthermore, the material was examined after bone maceration and histologically...
February 23, 2017: Tierärztliche Praxis. Ausgabe G, Grosstiere/Nutztiere
https://www.readbyqxmd.com/read/28227658/evaluating-the-deflection-of-dexterous-continuum-manipulators-with-unevenly-distributed-compliant-joints
#2
Anzhu Gao, Ryan J Murphy, Hao Liu, Iulian Iordachita, Mehran Armand, Anzhu Gao, Ryan J Murphy, Hao Liu, Iulian Iordachita, Mehran Armand, Hao Liu, Anzhu Gao, Iulian Iordachita, Mehran Armand, Ryan J Murphy
Dexterous continuum manipulators (DCMs) offer great potential for increasing instrument reach in minimally-invasive surgical procedures. We previously designed and fabricated a tendon driven DCM with a large instrument channel and evenly distributed compliant joints for minimally-invasive skull base surgery and the treatment of osteolysis during hip revision surgery. The evenly distributed compliant joints, in some cases, may limit the reach of the DCM during lesion removal. In this paper, we propose a finite element analysis (FEA) method for optimizing the distribution of the compliant joints based on treatment space requirements determined preoperatively...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28222212/excellent-mid-term-results-of-a-new-polished-tapered-modular-cemented-stem-a-study-of-113-hip-replacements-with-minimum-5-year-follow-up
#3
Jens Vanbiervliet, Jan F A Somers
BACKGROUND: This prospective cohort study reports the medium-term clinical and radiographic results of 113 hips treated with a hybrid total hip replacement (THR) with a new cemented tapered cobalt-chrome (Co-Cr) stem with a titanium (Ti) modular neck (ProfemurXm®). METHOD: Between October 2008 and December 2010 we performed 115 consecutive hybrid THR with the ProfemurXm® in 105 patients. RESULTS: Survivorship of the implant (stem and modular neck) at a mean of 6...
February 18, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/28216760/vanishing-bone-disease-of-chest-wall-and-spine-with-kyphoscoliosis-and-neurological-deficit-a-case-report-and-review-of-literature
#4
Sudhir Kumar Srivastava, Rishi Anil Aggarwal, Pradip Sharad Nemade, Sunil Krishna Bhoale
Vanishing bone disease is an extremely rare disorder of unknown etiology characterized by idiopathic osteolysis of bone. We describe a case of vanishing bone disease of chest wall and spine with kyphoscoliosis and neurological deficit. A 17-year-old male presented with gradually progressive deformity of back and dorsal compressive myelopathy with nonambulatory power in lower limbs. Radiographs revealed absent 4(th)-7(th) ribs on the right side with dorsal kyphoscoliosis and severe canal narrowing at the apex...
January 2017: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/28215222/nf-%C3%AE%C2%BAb-as-a-therapeutic-target-in-inflammatory-associated-bone-diseases
#5
T-H Lin, J Pajarinen, L Lu, A Nabeshima, L A Cordova, Z Yao, S B Goodman
Inflammation is a defensive mechanism for pathogen clearance and maintaining tissue homeostasis. In the skeletal system, inflammation is closely associated with many bone disorders including fractures, nonunions, periprosthetic osteolysis (bone loss around orthopedic implants), and osteoporosis. Acute inflammation is a critical step for proper bone-healing and bone-remodeling processes. On the other hand, chronic inflammation with excessive proinflammatory cytokines disrupts the balance of skeletal homeostasis involving osteoblastic (bone formation) and osteoclastic (bone resorption) activities...
2017: Advances in Protein Chemistry and Structural Biology
https://www.readbyqxmd.com/read/28210968/study-on-critical-sized-ultra-high-molecular-weight-polyethylene-wear-particles-loaded-with-alendronate-sodium-in-vitro-release-and-cell-response
#6
Yumei Liu, Feng Shi, Kemeng Gong, Yang Liu, Wei Zhi, Jie Weng, Shuxin Qu
The aim of this study was to investigate the in vitro release and the effect of RAW 264.7 macrophages of critical-sized wear particles of ultra-high molecular weight polyethylene (UHMWPE) loaded with alendronate sodium (ALN), one of the most effective drugs to treat osteoporosis in clinic. The critical-sized UHMWPE-ALN 0.5 wt.% wear particles were prepared by vacuum gradient filtration combined with Pluronic F-68. In vitro release of ALN from critical-sized UHMWPE-ALN wear particles was investigated in phosphate buffered saline (PBS) at 37 °C with a shaker...
April 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28209339/vitamin-e-stabilized-highly-crosslinked-polyethylenes-the-role-and-effectiveness-in-total-hip-arthroplasty
#7
Kengo Yamamoto, Toshiyuki Tateiwa, Yasuhito Takahashi
Morphology and design of ultra-high molecular weight polyethylene (UHMWPE or simply PE) acetabular components used in total hip arthroplasty (THA) have been evolving for more than half a century. Since the late-1990s, there were two major technological innovations in PE emerged from necessity to overcome the wear-induced periprosthetic osteolysis, i.e., the development of highly crosslinked PEs (HXLPEs). There are many literature reporting that radiation crosslinked and remelted/annealed (first-generation) HXLPEs markedly reduced the incidence of osteolysis and aseptic loosening...
February 10, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/28208071/anthocyanin-suppresses-cocrmo-particle-induced-osteolysis-by-inhibiting-ikk%C3%AE-%C3%AE-mediated-nf-%C3%AE%C2%BAb-signaling-in-a-mouse-calvarial-model
#8
Yamin Li, Juehong Li, Bin Li, Hui Qin, Xiaochun Peng, Yaochao Zhao, Yunsu Chen
Wear particle-induced osteolysis and bone resorption have been identified as critical factors of implant failure and total joint revision, in which nuclear factor kappa B (NF-κB) signaling and chronic inflammation have been shown to play key roles. Although anthocyanin is known to have anti-inflammatory function via blocking NF-κB pathway, it is still unclear whether anthocyanin has a protective effect on particle-induced osteolysis. In the present study, we aimed to investigate the detailed effects and the underlying mechanism of anthocyanin on CoCrMo particle-induced osteolysis in a mouse calvavial model...
February 13, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28197150/curcumin-attenuates-titanium-particle-induced-inflammation-by-regulating-macrophage-polarization-in-vitro-and-in-vivo
#9
Bin Li, Yan Hu, Yaochao Zhao, Mengqi Cheng, Hui Qin, Tao Cheng, Qiaojie Wang, Xiaochun Peng, Xianlong Zhang
Periprosthetic inflammatory osteolysis and subsequent aseptic loosening are commonly observed in total joint arthroplasty. Other than revision surgery, few approved treatments are available for this complication. Wear particle-induced inflammation and macrophage polarization state play critical roles in periprosthetic osteolysis. We investigated the effects of curcumin, a polyphenol extracted from Curcuma longa, on titanium (Ti) particle-induced inflammation and macrophage polarization in vitro using the murine cell line RAW 264...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28194401/clinical-application-of-cone-beam-computed-tomography-of-the-rabbit-head-part-2-dental-disease
#10
G G Riggs, Derek D Cissell, Boaz Arzi, David C Hatcher, Philip H Kass, Amy Zhen, Frank J M Verstraete
Domestic rabbits are increasing in popularity as household pets; therefore, veterinarians need to be familiar with the most common diseases afflicting rabbits including dental disease. Current diagnostic approaches include gross oral examination, endoscopic oral examination, skull radiography, and computed tomography (CT). Cone beam computed tomography (CBCT), a new oral and maxillofacial imaging modality that has the capability to produce high-resolution images, has not yet been described for use in evaluating dental disease in rabbits...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28186845/image-findings-of-bisphosphonate-related-osteonecrosis-of-jaws-comparing-with-osteoradionecrosis
#11
Kenichi Obinata, Shinichi Shirai, Hitoshi Ito, Motoyasu Nakamura, Marco Carrozzo, Iain Macleod, Andrew Carr, Yutaka Yamazaki, Kanchu Tei
OBJECTIVES: The aim of this study was to evaluate image characteristics of bisphosphonate related osteonecrosis of the jaws (BRONJ) and compare these with osteoradionecrosis (ORN). METHODS: Thirty-four patients with BRONJ and 16 patients with ORN were included in this study. We investigated the computed tomography (CT) and Dental Panoramic Radiograph (DPR) images for osteolysis, osteosclerosis, sequesteration, periosteal reaction, pathological fracture, and spread of soft tissue inflammation around the jaws...
February 10, 2017: Dento Maxillo Facial Radiology
https://www.readbyqxmd.com/read/28186447/cranioplasty-with-autogenous-bone-flaps-cryopreserved-in-povidone-iodine-a-long-term-follow-up-study
#12
Jian Zhang, Fei Peng, Zhuang Liu, Jinli Luan, Xingming Liu, Chang Fei, Xueyuan Heng
OBJECTIVE The aim of this study was to investigate the long-term therapeutic efficacy of cranioplasty with autogenous bone flaps cryopreserved in povidone iodine and explore the risk factors for bone resorption. METHODS Clinical data and follow-up results of 188 patients (with 211 bone flaps) who underwent cranioplasty with autogenous bone flaps cryopreserved in povidone-iodine were retrospectively analyzed. Bone flap resorption was classified into 3 types according to CT features, including bone flap thinning (Type I), reduced bone density (Type II), and osteolysis within the flaps (Type III)...
February 10, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28184362/uncemented-total-hip-replacement-after-two-years-of-neglected-hip-dislocation-with-fracture-of-posterior-column-and-wall-of-the-acetabulum
#13
Sundaresh Dc, Sharath K Ramanath, Amit Grover, Daksh Gadi
INTRODUCTION: Posterior hip dislocation of the hip with acetabular fracture is a challenging problem to treat. Such dislocations are associated with avascular necrosis of the femoral head if neglected. Managing such conditions with total hip replacement (THR) is very difficult because of associated altered anatomy. CASE PRESENTATION: We hereby report a two-year neglected hip dislocation with associated acetabular fracture successfully treated with uncemented THR...
November 2016: Trauma Monthly
https://www.readbyqxmd.com/read/28177150/commentary-the-skeleton-is-a-storehouse-of-mineral-that-is-plundered-during-lactation-and-fully-replenished-afterwards
#14
Christopher S Kovacs
During lactation, mammals resorb mineral from the maternal skeleton to provide calcium to milk. Rodents lose 25-35% of skeletal ash weight, ash calcium content, and bone mineral content by DXA, and have compromised material properties of bone, as assessed by crushing vertebrae and 3-pt bend tests of femora or tibiae. The strength, stiffness, and toughness of vertebrae, femora, and tibiae are reduced by as much as 60%. The effects of lactation are not uniform throughout the skeleton, but instead resorption is much more marked in the trabecular-rich spine than in the appendicular skeleton or whole body...
February 8, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28167871/clinical-results-of-oxidized-zirconium-femoral-component-in-tka-a-review-of-long-term-survival-review-article
#15
REVIEW
Roberto Civinini, Fabrizio Matassi, Christian Carulli, Luigi Sirleo, Andrea Cozzi Lepri, Massimo Innocenti
BACKGROUND: Oxidized zirconium (OxZr) femoral component for total knee arthroplasty (TKA) have been introduced in an attempt to reduce polyethylene wear and secondary osteolysis and improve longevity of implants. QUESTIONS/PURPOSES: We reviewed clinical studies in literature evaluating OxZr femoral component for TKA. The aim of this review was to evaluate the clinical outcome and survival rate of TKA with an OxZr femoral component. METHODS: A review of the existing literature was undertaken to collect data on the OxZr femoral component in order to provide a better understanding of its performance...
February 2017: HSS Journal: the Musculoskeletal Journal of Hospital for Special Surgery
https://www.readbyqxmd.com/read/28165590/survival-of-hydroxyapatite-coated-cups-acetabular-screws-involve-a-lower-rate-of-revision-surgery-due-to-aseptic-loosening
#16
Luis Natera, Marius Valera, Esther Moya Gómez, Natalia Ibañez, Xavier Crusi, Rogelio Sancho
BACKGROUND: It is believed that the path of acetabular screws may represent a shuttle between hydroxyapatite (HA) particles and the liner. The aim was to assess the relationship between acetabular screws and revision surgery for aseptic loosening in total hip arthroplasties (THAs). MATERIAL AND METHODS: A retrospective multicentric study was performed. Patients older than 18 years and patients who underwent THA with both the stem and cup HA-coated were included...
January 28, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/28164052/treatment-of-stiff-elbow-in-young-patients-with-interpositional-arthroplasty-for-mobility-case-series
#17
R Sivakumar, V SomaSheker, Prahalad Kumar Shingi, T Vinoth, M Chidambaram
INTRODUCTION: The elbow is a complex joint involving many articulations and complex biomechanics come into play. Elbow motion is crucial to upper limb movement that loss of 50% of elbow function equals to loss of 80% of upper extremity global function. Restoring movement and stability is challenging to the surgeon while treating a stiff elbow. Unlike other arthroplasties of hip and knee, total elbow arthroplasty (TEA) may not be a primary treatment. Interpositional arthroplasty (IPA) can be considered a viable option in posttraumatic arthritis of elbow in young patients...
September 2016: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28161662/release-of-metal-ions-from-nano-cocrmo-wear-debris-generated-from-tribo-corrosion-processes-in-artificial-hip-implants
#18
Yang Wang, Yu Yan, Yanjing Su, Lijie Qiao
CoCrMo alloys have been widely used in metal-on-metal (MoM) hip replacements due to their superior wear and corrosion resistance properties. However, metal ions like Co(2+) and Cr(3+), or even Cr(6+) released from CoCrMo hip prostheses can induce macrophage apoptotic vs. necrotic mortality and damage the surrounding tissues. Simultaneously, osteolysis induced by the wear debris can be a cause of failure. Nano wear debris is more active than the bulk material, due to its small size. In this study, to accurately analyse the fresh wear debris retrieved from the hip simulator and the interaction between the particles and tribocorrosion of CoCrMo, wear debris was observed without protein digest, using a combined experimental approach involving the employment of TEM and ICP-MS...
January 30, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28161138/prognosis-of-advanced-tenosynovial-giant-cell-tumor-of-the-knee-diagnosed-during-total-knee-arthroplasty
#19
Pengfei Lei, Rongxin Sun, Hao Liu, Jianxi Zhu, Ting Wen, Yihe Hu
BACKGROUND: Tenosynovial giant cell tumor (TGCT) is a relatively rare disease often misdiagnosed as osteoarthritis. Synovectomy or arthroplasty is the recommended treatment option, but recurrence is common after surgery. This study aimed to determine the prognosis of patients with advanced TGCT that was diagnosed incidentally during total knee arthroplasty (TKA) for osteoarthritis and treated by synovectomy. METHODS: From January 2008 to July 2011, TGCT was diagnosed incidentally in 10 patients (a total of 11 individual knees) undergoing posterior-stabilized TKA for an initial diagnosis of osteoarthritis...
January 11, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28154552/chemokines-associated-with-pathologic-responses-to-orthopedic-implant-debris
#20
REVIEW
Nadim J Hallab, Joshua J Jacobs
Despite the success in returning people to health saving mobility and high quality of life, the over 1 million total joint replacements implanted in the US each year are expected to eventually fail after approximately 15-25 years of use, due to slow progressive subtle inflammation to implant debris compromising the bone implant interface. This local inflammatory pseudo disease state is primarily caused by implant debris interaction with innate immune cells, i.e., macrophages. This implant debris can also activate an adaptive immune reaction giving rise to the concept of implant-related metal sensitivity...
2017: Frontiers in Endocrinology
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