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https://www.readbyqxmd.com/read/28548682/arthrotomy-based-pre-clinical-models-of-particle-induced-osteolysis-a-systematic-review
#1
REVIEW
Meghan M Moran, Brittany M Wilson, Ryan D Ross, Amarjit S Virdi, D Rick Sumner
We completed a systematic literature review of in vivo animal models that use arthrotomy-based methods to study particle-induced peri-implant osteolysis. The purpose of the review was to characterize the models developed to date, to determine the questions addressed, to assess scientific rigor and transparency and to identify gaps in knowledge. We probed three literature databases (Medline, Embase and Scopus) and found 77 manuscripts that fit the search parameters. In the most recent 10 years, researchers mainly used rat and mouse models, whereas in the previous 20 years large animal, canine and rabbit models were more common...
May 26, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28540566/-osteosynthesis-associated-infections-epidemiology-definition-and-diagnosis
#2
REVIEW
N Renz, S Feihl, C E Dlaska, M A Schütz, A Trampuz
Osteosynthesis-associated infections occur in 1-5% after closed and in up to 30% after open fractures. There are three different descriptions of implant-associated infections after fracture fixation, which are crucial for the selection of the adequate treatment strategy; temporal appearance from the index surgery (early versus late), pathogenesis of the infection (exogenous, hematogenous and contiguous from an adjacent focus), duration of infection symptoms (acute versus chronic). Diagnosis of osteosynthesis-associated infection is challenging, as chronic low-grade infections often present only with unspecific and subtle clinical symptoms...
May 24, 2017: Der Unfallchirurg
https://www.readbyqxmd.com/read/28535724/long-term-results-of-scandinavian-total-ankle-replacement
#3
Helka Koivu, Ia Kohonen, Kimmo Mattila, Eliisa Loyttyniemi, Hannu Tiusanen
BACKGROUND: The purpose of this study was to evaluate the long-term results of the Scandinavian Total Ankle Replacement (STAR) implant in a single center. METHODS: Between 1997 and 2002, 34 consecutive ankles were replaced with the STAR ankle prosthesis and reviewed in 2016. Patients were followed both radiologically and clinically; clinical outcomes were measured with the Kofoed ankle score and subjective measurements. The median follow-up period was 159 months (13...
May 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28535038/fabrication-of-a-biodegradable-implant-with-tunable-characteristics-for-bone-implant-applications
#4
Iman Manavitehrani, Ali Fathi, Yiwei Wang, Peter K Maitz, Farid Mirmohseni, Tegan L Cheng, Lauren Peacock, David G Little, Aaron Schindeler, Fariba Dehghani
Biodegradable polymers are appealing material for the manufacturing of surgical implants as such implants break down in vivo, negating the need for a subsequent operation for removal. Many biocompatible polymers produce acidic breakdown products that can lead to localized inflammation and osteolysis. This study assesses the feasibility of fabricating implants out of poly(propylene carbonate) (PPC)-starch that degrades into CO2 and water. The basic compression modulus of PPC-starch (1:1 w/w) is 34 MPa; however, the addition of glycerol (1% w/w) and water as plasticizers doubles this value and enhances the surface wettability...
May 23, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28529307/genetic-deletion-of-sost-or-pharmacological-inhibition-of-sclerostin-prevent-multiple-myeloma-induced-bone-disease-without-affecting-tumor-growth
#5
J Delgado-Calle, J Anderson, M D Cregor, K W Condon, S A Kuhstoss, L I Plotkin, T Bellido, G D Roodman
Multiple myeloma (MM) causes lytic bone lesions due to increased bone resorption and concomitant marked suppression of bone formation. Sclerostin (Scl) levels, an osteocyte-derived inhibitor of Wnt/β-catenin signaling, are elevated in MM patient sera and are increased in osteocytes in MM-bearing mice. We show here that genetic deletion of Sost, the gene encoding Scl, prevented MM-induced bone disease in an immune-deficient mouse model of early MM, and that administration of anti-Scl antibody (Scl-Ab) increased bone mass and decreases osteolysis in immune-competent mice with established MM...
May 22, 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/28529108/a-3-to-18-year-follow-up-of-revision-total-hip-arthroplasty-with-impacted-bone-allografts-and-cemented-lubinus-sp-ii-stem-clinical-radiographic-and-survivorship-analysis-with-comparison-to-the-literature
#6
Hampus Stigbrand, Gösta Ullmark
BACKGROUND: We present the first medium- to long-term follow-up of revision total hip arthroplasty using impaction bone grafting (IBG) combined with the matte and collared Lubinus SP II stem for cases of severe osteolysis and stem loosening. METHODS: Sixty-nine femoral revisions were identified for 67 patients consecutively operated with revision femoral arthroplasty using IBG and a cemented Lubinus SP II stem. The mean age was 69 years (standard deviation, 9.9)...
April 18, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28522401/comparison-of-the-osteogenesis-and-fusion-rates-between-activin-a-bmp-2-chimera-ab204-and-rhbmp-2-in-a-beagle-s-posterolateral-lumbar-spine-model
#7
Guang Bin Zheng, Byung-Hak Yoon, Jae Hyup Lee
BACKGROUND CONTEXT: Activin A/BMP-2 chimera (AB204) could promote bone healing more effectively than recombinant bone morphogenetic protein 2 (rhBMP-2) with much lower dose in rodent model, but there is no report about the effectiveness of AB204 in a large animal model. PURPOSE: The purpose of this study was to compare the osteogenesis and fusion rate between AB204 and rhBMP-2 using biphasic calcium phosphate (BCP) as a carrier in beagle's posterolateral lumbar fusion model...
May 15, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28511839/the-implication-of-the-osteolysis-threshold-and-interfacial-gaps-on-periprosthetic-osteolysis-in-cementless-total-hip-replacement
#8
Hamidreza Alidousti, Neil W Bressloff
Osteolysis around joint replacements may develop due to migration of wear particles from the joint space into gaps between the interface bone and the implant where they can accumulate in high concentrations to cause tissue damage. Osteolysis may appear in various postoperative times and morphological shapes which can be generalized into linear and focal. However, there are no clear explanations on the causes of such variations. Patients' degree of sensitivity to polyethylene particles (osteolysis thresholds), the local particle concentration and the access route provided by the interface gaps have been described as determining factors...
May 5, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28507777/the-role-of-isolated-polyethylene-exchange-in-total-knee-arthroplasty
#9
REVIEW
Hee-Nee Pang, Hamid Rahmatullah Bin Abd Razak, Stephen Petis, Douglas D R Naudie, Steven J MacDonald
The use of modular total knee arthroplasty (TKA) implants allows surgeons to perform isolated tibial polyethylene insert exchange (IPE) while retaining well-fixed and stable components.The purported advantages of IPE include preservation of bone stock, shorter operating time, less blood loss, faster rehabilitation and lower cost. However, the indications for IPE are limited.IPE for wear and osteolysis has moderate success in the medium term but should be avoided in cases of accelerated wear. In selected cases, debridement and IPE for early infection can result in low morbidity with high success rates in the short term...
March 2017: EFORT Open Rev
https://www.readbyqxmd.com/read/28506299/developmental-hip-dysplasia-treated-by-total-hip-arthroplasty-using-a-cementless-wagner-cone-stem-in-young-adult-patients-with-a-small-physique
#10
Ping Zhen, Jun Liu, Hao Lu, Hui Chen, Xusheng Li, Shenghu Zhou
BACKGROUND: Developmental hip dysplasia (DDH) may lead to severe acetabular and femoral abnormalities that can render total hip arthroplasty (THA) challenging, especially in DDH patients with a small physique. Most conventional cemented or cementless femoral components are often difficult to implant in the narrow femoral canal and require slight version correction during surgery. The aim of this study was to present the mid-term results of THA in the treatment of DDH patients with a small physique using a cementless Wagner cone prosthesis (Zimmer®, US)...
May 15, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28502348/osteolysis-in-total-ankle-replacement-how-does-it-work
#11
REVIEW
Norman Espinosa, Georg Klammer, Stephan H Wirth
Aseptic loosening of implants remains the most common reason for revision surgery for hip, knee, or ankle prostheses. Although a great scientific effort has been made to explain the underlying mechanisms it remains poorly understood, complex, and multifactorial. Many factors, including age, body weight, activity lesions, implant design, fixation methods, material proprieties, immunologic responses, and biomechanical adaptations to total ankle replacement all contribute to the development of periprosthetic osteolysis...
June 2017: Foot and Ankle Clinics
https://www.readbyqxmd.com/read/28500495/causes-for-early-and-late-surgical-re-intervention-after-radial-head-arthroplasty
#12
Pierre Laumonerie, David Ancelin, Nicolas Reina, Meagan E Tibbo, Panagiotis Kerezoudis, Stephanie Delclaux, Nicolas Bonnevialle, Pierre Mansat
PURPOSE: The primary objective was to describe the reasons for surgical re-intervention after radial head arthroplasty. The secondary objective was to analyze the radiographic and clinical outcomes after surgical re-intervention at the elbow with implant conservation. METHODS: Among the 70 radial head arthroplasties with bipolar radial head implant performed between 2002 and 2014, 29 required surgical re-interventions. Reasons for surgical re-intervention were gathered from operative notes and follow-up documentation...
May 12, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28499894/pathophysiology-of-bone-metastases-from-solid-malignancies
#13
Philippe Clézardin
Bone metastases are common complications of many cancers. Among the mechanisms that set the scene for the development of bone metastases, several are shared by all forms of metastatic dissemination (pre-metastatic niche formation and chemotactic attraction of malignant cells, which invade the host tissue) and others are specific of bone tissue (homing of malignant cells to bone marrow niches and acquisition of an osteomimetic cell phenotype). After a latency period that can last several years, the malignant cells can proliferate into tumors that alter the normal bone remodeling process by inducing dysregulation of osteoblast and osteoclast function...
May 9, 2017: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/28494462/in-vitro-growth-pattern-of-primary-human-osteoblasts-on-calcium-phosphate-and-polymethylmethacrylate-based-bone-cement
#14
Johannes Schauwecker, Mark Bock, Florian Pohlig, Heinz Mühlhofer, Jutta Tübel, Rüdiger von Eisenhart-Rothe, Chlodwig Kirchhoff
BACKGROUND/PURPOSE: Polymethylmethacrylate (PMMA) and calcium phosphate (Ca-P) cements are widely used for arthroplasty surgery and augmentation of bone defects. However, aseptic implant loosening in absence of wear-induced osteolysis indicates an unfavourable interaction between the cement surface and human osteoblasts. Our underlying hypothesis is that cement surfaces directly modify cell viability, proliferation rate, and cell differentiation. METHODS: To test this hypothesis, we examined primary human osteoblasts harvested from six individuals...
May 12, 2017: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/28490011/new-interleukins-in-psoriasis-and-psoriatic-arthritis-patients-the-possible-roles-of-interleukin-33-to-interleukin-38-in-disease-activities-and-bone-erosions
#15
Jiang Li, Lei Liu, Wenlong Rui, Xiangyu Li, Dandan Xuan, Shucong Zheng, Yiyun Yu, Jiong Zhang, Ning Kong, Xiaoxia Zhu, Hejian Zou, Weiguo Wan, Yu Xue
OBJECTIVES: New interleukins (ILs), especially members of IL-1 and IL-12 families, have recently been reported to be involved in the development and regulation of autoimmune and inflammatory diseases. In this study, we aimed to explore the impact of these new ILs in psoriasis (Ps) and psoriatic arthritis (PsA). METHODS: Forty PsA patients, 20 Ps patients, and 20 healthy controls (HCs) were recruited. Blood samples were obtained for detecting the levels of ILs, IL-12/23p40, and tumor necrosis factor α (TNF-α)...
May 10, 2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/28482493/advances-in-ultra-high-molecular-weight-polyethylene-hydroxyapatite-composites-for-biomedical-applications-a-brief-review
#16
REVIEW
Domingos Lusitâneo Pier Macuvele, Janaína Nones, Jonas V Matsinhe, Marla M Lima, Cíntia Soares, Márcio A Fiori, Humberto G Riella
Ultra high molecular weight polyethylene (UHMWPE) is a semicrystalline polymer that has been applied, as a bearing surface in total human joint replacements and artificial bones. UHMWPE has a superior wear resistance, low-friction surface, biological inertness, high levels of strength, creep resistance and low friction coefficient. However, the wear debris generated during the joint motions could cause problem in human implant, such as osteolysis and loosening. For this, several attempts was been made to improve UHMWPE properties and increases safety and biocompatibility in human implants...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28476105/case-of-disseminated-histoplasmosis-in-a-hiv-infected-patient-revealed-by-nasal-involvement-with-maxillary-osteolysis
#17
A C Lehur, M Zielinski, J Pluvy, V Grégoire, S Diamantis, A Bleibtreu, C Rioux, A Picard, D Vallois
BACKGROUND: Disseminated Histoplasmosis (DH) is a rare manifestation of Acquired Immune Deficiency Syndrome (AIDS) in European countries. Naso-maxillar osteolysis due to Histoplasma capsulatum var. capsulatum (Hcc) is unusual in endemic countries and has never been reported in European countries. Differential diagnoses such as malignant tumors, cocaine use, granulomatosis, vasculitis and infections are more frequently observed and could delay and/or bias the final diagnosis. CASE PRESENTATION: We report the case of an immunocompromised patient infected by Human Immunodeficiency Virus (HIV) with naso-maxillar histoplasmosis in a non-endemic country...
May 5, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28467965/intratumoral-acidosis-fosters-cancer-induced-bone-pain-through-the-activation-of-the-mesenchymal-tumor-associated-stroma-in-bone-metastasis-from-breast-carcinoma
#18
Gemma Di Pompo, Silvia Lemma, Lorenzo Canti, Nadia Rucci, Marco Ponzetti, Costantino Errani, Davide Maria Donati, Shonagh Russell, Robert Gillies, Tokuhiro Chano, Nicola Baldini, Sofia Avnet
Cancer-induced bone pain (CIBP) is common in patients with bone metastases (BM), significantly impairing quality of life. The current treatments for CIBP are limited since they are often ineffective. Local acidosis derived from glycolytic carcinoma and tumor-induced osteolysis is only barely explored cause of pain. We found that breast carcinoma cells that prefer bone as a metastatic site have very high extracellular proton efflux and expression of pumps/ion transporters associated with acid-base balance (MCT4, CA9, and V-ATPase)...
April 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28463620/robotic-versus-fluoroscopy-guided-pedicle-screw-insertion-for-metastatic-spinal-disease-a-matched-cohort-comparison
#19
Volodymyr Solomiichuk, Julius Fleischhammer, Granit Molliqaj, Jwad Warda, Awad Alaid, Kajetan von Eckardstein, Karl Schaller, Enrico Tessitore, Veit Rohde, Bawarjan Schatlo
OBJECTIVE Robot-guided pedicle screw placement is an established technique for the placement of pedicle screws. However, most studies have focused on degenerative disease. In this paper, the authors focus on metastatic spinal disease, which is associated with osteolysis. The associated lack of dense bone may potentially affect the automatic recognition accuracy of radiography-based surgical assistance systems. The aim of the present study is to compare the accuracy of the SpineAssist robot system with conventional fluoroscopy-guided pedicle screw placement for thoracolumbar metastatic spinal disease...
May 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/28462686/midterm-outcome-of-the-agility-total-ankle-arthroplasty
#20
Steven M Raikin, Kristin Sandrowski, Justin M Kane, David Beck, Brian S Winters
BACKGROUND: Ankle arthritis is a debilitating condition that causes severe functional impairment. While arthrodesis has been the gold standard of surgical treatment for this condition, significant improvements in total ankle arthroplasty have made it a viable alternative. The purpose of this study was to look at the midterm follow-up of the Agility total ankle. METHODS: A retrospective review of prospectively collected data was conducted on 127 consecutive Agility total ankles implanted between 2002 and 2009...
April 1, 2017: Foot & Ankle International
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