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Osmotic delivery systems

Apurv Patel, Hitesh Dodiya, Pragna Shelate, Divyesh Shastri, Divyang Dave
The objective of this work was design, characterization, and optimization of controlled drug delivery system containing antibiotic drug/s. Osmotic drug delivery system was chosen as controlled drug delivery system. The porous osmotic pump tablets were designed using Plackett-Burman and Box-Behnken factorial design to find out the best formulation. For screening of three categories of polymers, six independent variables were chosen for Plackett-Burman design. Osmotic agent sodium chloride and microcrystalline cellulose, pore forming agent sodium lauryl sulphate and sucrose, and coating agent ethyl cellulose and cellulose acetate were chosen as independent variables...
2016: Journal of Drug Delivery
Ling Lan, Yu-Guan Zhang, Jin Wang, Ya-Hong Gong
<p>Dilutional hyponatremia caused by excess absorption of hypo-osmotic irrigation fluids is one of the severe complications during hysteroscopic surgery. Appropriate delivery system and distending media,proper distending pressure,and reducing destruction of uterine venous sinus may remarkably lower the morbidity. Meanwhile,early detection and timely treatment of moderate and severe hyponatremia to avoid the occurrence of secondary nervous system demyelination are particularly important during the surgery...
August 2016: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
Sarah D Hann, Tagbo H R Niepa, Kathleen J Stebe, Daeyeon Lee
Diverse fields including drug and gene delivery and live cell encapsulation require biologically compatible encapsulation systems. One widely adopted means of forming capsules exploits cargo-filled microdroplets in an external, immiscible liquid phase that are encapsulated by a membrane that forms by trapping of molecules or particles at the drop surface, facilitated by the interfacial tension. To eliminate the potentially deleterious oil phase often present in such processes, we exploit the aqueous two phase system of poly(ethylene glycol) (PEG) and dextran...
September 28, 2016: ACS Applied Materials & Interfaces
Li Wu, Lebing Wang, Shuxia Wang, Tiqiao Xiao, Min Chen, Qun Shao, Peter York, Vikaramjeet Singh, Xianzhen Yin, Jingkai Gu, Jiwen Zhang
The orifice drilled in the membrane as a channel for drug delivery is the key functional part of the osmotic pumps for a controlled drug release system. Reported conventional microscopic evaluations of these orifices have been limited to measurement of two-dimensional cross-section diameters. This study was aimed at establishing a novel method to measure quantitatively the three-dimensional architectures of orifices based on synchrotron radiation X-ray microcomputed tomography (SR-μCT). Quantitative analysis of architectures extracted from captopril osmotic pumps drilled by a range of operating parameters indicated that laser power correlated with the cross section area, volume, surface area and depth of the orifices, while scanning speed of laser beam showed inverse relationships with the above structure characters...
October 10, 2016: European Journal of Pharmaceutical Sciences
Aruna Sharma, Preeti Menon, Dafin F Muresanu, Asya Ozkizilcik, Z Ryan Tian, José V Lafuente, Hari Sharma
The BBB is a physiological regulator of transport of essential items from blood to brain for the maintenance of homeostasis of the central nervous system (CNS) within the narrow limit. The BBB is also responsible for export of harmful or metabolic products from brain to blood to keep the fluid microenvironment of the CNS healthy. However, following any noxious insult to the brain caused by trauma, ischemia or environmental/chemical toxins the function of the BBB is altered to small as well as to large molecules e...
August 19, 2016: CNS & Neurological Disorders Drug Targets
P T Pollak, R J Herman, R D Feldman
OBJECTIVE: Anecdotal evidence suggested clinically important systolic blood pressure (SBP) differences occurred in our patients whose nifedipine was being switched by pharmacies between AdN (Adalat XL - a formulation providing zero order release from the GastroIntestinal Therapeutic System - GITS) and MyN (Mylan-nifedipine ER - a formulation providing a delayed first-order release from the Osmotic Release Oral System - OROS). In vitro dissolution studies showed greater lag time to initial release from MyN and declining release at end of dosing interval...
September 2016: Journal of Hypertension
Soo-Young Bhang, Jun-Won Hwang, Young-Sook Kwak, Yoo Sook Joung, Soyoung Lee, Bongseog Kim, Seok Han Sohn, Un Sun Chung, Jaewon Yang, Minha Hong, Geon Ho Bahn, Hyung Yun Choi, In-Hwan Oh, Yeon Jung Lee
We evaluated the differences in utilization patterns including persistence and adherence among medications in children and adolescents with attention deficit hyperactivity disorder (ADHD). The current study was performed using data from the Korean Health Insurance Review and Assessment claims database from January 1, 2009 to December 31, 2013. Our study sample consisted of 10,343 children and adolescents with ADHD who were not given their newly prescribed medication in 360 days before the initial claim in 2010...
August 2016: Journal of Korean Medical Science
Yoon Chan Rah, Min Young Lee, Shin Hye Kim, Doo Hee Kim, Hayden Eastwood, Stephen J O'Leary, Jun Ho Lee
CONCLUSION: Seven-day administration of systemic steroids was more effective in preserving hearing for 12 weeks after cochlear implantation (CI) than a 3-day delivery. OBJECTIVES: To determine the effectiveness of extended delivery of systemic steroids to preserve hearing in guinea pigs after CI. METHODS: Dexamethasone (4 mg/ml) was delivered parenterally via a mini-osmotic pump for either 3 or 7 days. A dummy CI electrode was inserted via cochleostomy approach in 8-week-old guinea pigs...
July 28, 2016: Acta Oto-laryngologica
Ghazaul Dezfuli, Kenneth J Kellar, Kenneth L Dretchen, Yousef Tizabi, Niaz Sahibzada, Richard A Gillis
Nicotine's effect on food intake and body weight has been well documented; however, the relevant receptors underlying these effects have not been firmly established. The purpose of the present study was to: (1) identify the nicotinic acetylcholine receptor (nAChR) subtype involved in food intake and body weight; (2) establish whether food intake and body weight reduction produced by nicotinic drugs are due to activation or desensitization of nAChRs; and, (3) assess the role of the melanocortin system in nicotinic drug effects on food intake and body weight...
November 2016: Neuropharmacology
Javier Urra, Jan Blohberger, Michelle Tiszavari, Artur Mayerhofer, Hernan E Lara
Growth and differentiation of ovarian follicles are regulated by systemic and local factors, which may include acetylcholine (ACh). Granulosa cells (GCs) of growing follicles and luteal cells produce ACh and in cultured GCs it exerts trophic actions via muscarinic receptors. However, such actions were not studied in vivo. After having established that rat ovarian GCs and luteal cells express the ACh-metabolizing enzyme ACh esterase (AChE), we examined the consequences of local application of an AChE inhibitor, huperzine A (HupA), by osmotic minipump delivery into the ovarian bursa of hemiovariectomized rats...
2016: Scientific Reports
Golandam Rezaei, Seyed Alireza Hosseini, Ali Akbari Sari, Alireza Olyaeemanesh, Mohamad Hassan Lotfi, Mojtaba Yassini, Reza Bidaki, Bijan Nouri
BACKGROUND: The aim of this study was to directly compare efficacy of atomoxetine and methylphenidate in treatment of children and adolescents 6- 18 years. METHODS: All published, randomized, open label or double blind trials, comparing the efficacy of methylphenidate with atomoxetine in treatment of children diagnosed with ADHD, using DSM-IV criteria were included in this study; ADHD Rating Scale-IV-Parent Version: Investigator Administered and Scored (ADHDRS) scores was used...
2016: Medical Journal of the Islamic Republic of Iran
Chong Qiu, Wei Wei, Jing Sun, Hai-Tao Zhang, Jing-Song Ding, Jian-Cheng Wang, Qiang Zhang
In this study, hyaluronan (HA)-functionalized calcium phosphate nanoparticles (CaP-AHA/siRNA NPs) were developed for an injectable and targetable delivery of siRNA, which were prepared by coating the alendronate-hyaluronan graft polymer (AHA) around the surface of calcium phosphate-siRNA co-precipitates. The prepared CaP-AHA/siRNA NPs had a uniform spherical core-shell morphology with an approximate size of 170 nm and zeta potential of -12 mV. The coating of hydrophilic HA improved the physical stability of nanoparticles over one month due to the strong interactions between phosphonate and calcium...
July 14, 2016: Nanoscale
Yue Yang, Zhinan Zhao, Yongfei Wang, Lu Yang, Dandan Liu, Xinggang Yang, Weisan Pan
In this study, a novel asymmetric membrane osmotic pump capsule of gliclazide (GLC) solid dispersion was developed to achieve a controlled drug release. The capsule shells were obtained by wet phase inversion process using cellulose acetate as semi-permeable membrane, glycerol and kolliphor P188 as pore formers, then filled with the mixture of GLC solid dispersion and pH modifiers. Differentiate from the conventional formulations, sodium carbonate was chosen as the osmotic agent and effervescent agent simultaneously to control the drug release, instead of the polymer materials...
June 15, 2016: International Journal of Pharmaceutics
Matthew Riddle, Anne Peters, Martha Funnell
Because of the progressive nature of type 2 diabetes mellitus (T2DM), the majority of patients will need insulin to achieve and maintain glycemic control. By maintaining glycemic control, patients will avoid acute osmotic symptoms of hyperglycemia, instability in plasma glucose (PG) over time, and prevent or delay the development of diabetes complications without adversely affecting quality of life. Despite recommendations for initiating insulin therapy, both patient and health system barriers stand in the way...
October 2016: Postgraduate Medicine
Shiqing Zhao, Fanglin Yu, Nan Liu, Zhong Di, Kun Yan, Yan Liu, Ying Li, Hui Zhang, Yang Yang, Zhenbo Yang, Zhiping Li, Xingguo Mei
The synchronous sustained-release of two drugs was desired urgently for patients needing combination therapy in long term. However, sophisticated technologies were used generally to realize the simultaneous delivery of two drugs especially those with different physico-chemical properties. The purpose of this study was to obtain the concurrent release of felodipine and metoprolol tartrate, two drugs with completely different solubilities, in a simple monolithic osmotic pump system (FMOP). Two types of blocking agents were used in monolithic osmotic pump tablets and the synchronous sustained-release of FMOP was acquired in vitro...
November 2016: Drug Development and Industrial Pharmacy
Jaber Emami, Mohammad-Reza Kazemali
Blood pressure rises rapidly upon awakening and maybe responsible, in part, for the increased incidence of myocardial infarction and stroke during the morning hours. The aim of the present study was, therefore, to develop a novel chronotherapeutic formulation of metoprolol tartrate (MT) for night time dosing providing maximum effect in the morning hours. Core tablets contained MT, sodium chloride, lactose, Avicel(®) and starch. Powders were mixed, sieved and directly compressed in to tablets using a single punch tablet machine...
January 2016: Research in Pharmaceutical Sciences
Lijie Wang, Xinggang Yang, Yan Di, Kai Chen, Haoyang Wen, Weisan Pan
BACKGROUND: In recent years, controlled and sustained release drug delivery system has become the focus of pharmaceutical researchers. Some technologies aimed to develop the controlled and sustained release of the drug, which used to be administered several times a day and generate plasma concentration fluctuation. As all, a controlled drug release rate has always been a goal pursued by researchers. This paper introduced a controlled delivery hydrophilic matrix system, and evaluated their relevance between in vitro and in vivo behaviors...
March 22, 2016: Current Drug Delivery
Loretta L del Mercato, Flora Guerra, Gianpiero Lazzari, Concetta Nobile, Cecilia Bucci, Rosaria Rinaldi
Graphene-based capsules have strong potential for a number of applications, including drug/gene delivery, tissue engineering, sensors, catalysis and reactors. The ability to integrate graphene into carrier systems with three-dimensional (3D) geometry may open new perspectives both for fundamental tests of graphene mechanics and for novel (bio)technological applications. However, the assembly of 3D complexes from graphene or its derivatives is challenging because of its poor stability under biological conditions...
April 14, 2016: Nanoscale
Qi-ping Zeng, Zhi-hong Liu, Ai-wen Huang, Jing Zhang, Hong-tao Song
The pharmacological activity of herbal medicine is an overall action of each component in accordance with their original proportion. An efficient, sustained, and controlled-release drug delivery system of herbal medicine should ensure the synchronized drug release of each active component during the entire release procedure. In this study, silymarin (SM), a poorly soluble herbal medicine, was selected as a model drug to develop a synchronized-release drug delivery system: an SM microporous osmotic pump (MPOP) tablet...
2016: Drug Design, Development and Therapy
Nadiya M Teplyuk, Erik J Uhlmann, Galina Gabriely, Natalia Volfovsky, Yang Wang, Jian Teng, Priya Karmali, Eric Marcusson, Merlene Peter, Athul Mohan, Yevgenya Kraytsberg, Ron Cialic, E Antonio Chiocca, Jakub Godlewski, Bakhos Tannous, Anna M Krichevsky
MicroRNA-10b (miR-10b) is a unique oncogenic miRNA that is highly expressed in all GBM subtypes, while absent in normal neuroglial cells of the brain. miR-10b inhibition strongly impairs proliferation and survival of cultured glioma cells, including glioma-initiating stem-like cells (GSC). Although several miR-10b targets have been identified previously, the common mechanism conferring the miR-10b-sustained viability of GSC is unknown. Here, we demonstrate that in heterogeneous GSC, miR-10b regulates cell cycle and alternative splicing, often through the non-canonical targeting via 5'UTRs of its target genes, including MBNL1-3, SART3, and RSRC1...
March 2016: EMBO Molecular Medicine
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