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Osmotic delivery systems

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https://www.readbyqxmd.com/read/28409734/intratumoral-delivery-of-bortezomib-impact-on-survival-in-an-intracranial-glioma-tumor-model
#1
Weijun Wang, Hee-Yeon Cho, Rachel Rosenstein-Sisson, Nagore I Marín Ramos, Ryan Price, Kyle Hurth, Axel H Schönthal, Florence M Hofman, Thomas C Chen
OBJECTIVE Glioblastoma (GBM) is the most prevalent and the most aggressive of primary brain tumors. There is currently no effective treatment for this tumor. The proteasome inhibitor bortezomib is effective for a variety of tumors, but not for GBM. The authors' goal was to demonstrate that bortezomib can be effective in the orthotopic GBM murine model if the appropriate method of drug delivery is used. In this study the Alzet mini-osmotic pump was used to bring the drug directly to the tumor in the brain, circumventing the blood-brain barrier; thus making bortezomib an effective treatment for GBM...
April 14, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28371725/age-related-pharmacotherapy-of-attention-deficit-hyperactivity-disorder-in-slovenia-in-children-and-adolescents-a-population-based-study
#2
M Stuhec, I Locatelli
BACKGROUND: There are no data on age-related pharmacotherapy for Attention Deficit Hyperactivity Disorder (ADHD) medication in children and adolescents in the most European countries. The main aim of this paper was to obtain that data for children and adolescents in Slovenia. METHOD: The number of ADHD drug prescriptions per patient was obtained from the health claims data on prescription drugs of the Health Insurance Institute of Slovenia for the study period (2003-2015)...
May 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28357656/physiologically-based-pharmacokinetic-and-absorption-modeling-for-osmotic-pump-products
#3
Zhanglin Ni, Arjang Talattof, Jianghong Fan, Eleftheria Tsakalozou, Satish Sharan, Dajun Sun, Hong Wen, Liang Zhao, Xinyuan Zhang
Physiologically based pharmacokinetic (PBPK) and absorption modeling approaches were employed for oral extended-release (ER) drug products based on an osmotic drug delivery system (osmotic pumps). The purpose was to systemically evaluate the in vivo relevance of in vitro dissolution for this type of formulation. As expected, in vitro dissolution appeared to be generally predictive of in vivo PK profiles, because of the unique feature of this delivery system that the in vitro and in vivo release of osmotic pump drug products is less susceptible to surrounding environment in the gastrointestinal (GI) tract such as pH, hydrodynamic, and food effects...
March 29, 2017: AAPS Journal
https://www.readbyqxmd.com/read/28331320/the-complex-of-pamam-oh-dendrimer-with-angiotensin-1-7-prevented-the-disuse-induced-skeletal-muscle-atrophy-in-mice
#4
Valeria Márquez-Miranda, Johanna Abrigo, Juan Carlos Rivera, Ingrid Araya-Durán, Javier Aravena, Felipe Simon, Nicolás Pacheco, Fernando Danilo González-Nilo, Claudio Cabello-Verrugio
Angiotensin (1-7) (Ang-(1-7)) is a bioactive heptapeptide with a short half-life and has beneficial effects in several tissues - among them, skeletal muscle - by preventing muscle atrophy. Dendrimers are promising vehicles for the protection and transport of numerous bioactive molecules. This work explored the use of a neutral, non-cytotoxic hydroxyl-terminated poly(amidoamine) (PAMAM-OH) dendrimer as an Ang-(1-7) carrier. Bioinformatics analysis showed that the Ang-(1-7)-binding capacity of the dendrimer presented a 2:1 molar ratio...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28295720/dual-phase-separation-in-a-semiconfined-system-monodispersed-heterogeneous-block-copolymer-membranes-for-cell-encoding-and-patterning
#5
Xiuyu Wang, Xueyan Feng, Guiping Ma, Di Zhang, Yahong Chai, Maofa Ge, Li Yao
Block copolymers (BCPs) have the capacity to self-assemble into a myriad of well-defined aggregate structures, offering great promise for the construction of drug delivery, photolithographic templates, and complex nanoscale assemblies. A uniqueness of these materials is their propensity to become kinetically frozen in non-equilibrium states, implying that the process of self-assembly can be utilized to remodel the resulting structures. Here, a new semiconfined system for processing the BCP self-assembly is constructed, in which an unusual dual-phase separation occurs, including nonsolvent-induced microphase separation and osmotically driven macrophase separation, ultimately yielding heterogeneous BCP membranes...
March 15, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28250103/the-nematocyst-s-sting-is-driven-by-the-tubule-moving-front
#6
Sinwook Park, Gadi Piriatinskiy, Dan Zeevi, Jonathan Ben-David, Gilad Yossifon, Uri Shavit, Tamar Lotan
The nematocyst is the explosive injection system of the phylum Cnidaria, and is one of the fastest delivery systems found in Nature. Exploring its injection mechanism is key for understanding predator-prey interactions and protection against jellyfish stinging. Here we analyse the injection of jellyfish nematocysts and ask how the build-up of the poly-γ-glutamate (pγGlu) osmotic potential inside the nematocyst drives its discharge. To control the osmotic potential, we used a two-channel microfluidic system to direct the elongating nematocyst tubule through oil, where no osmotic potential can develop, while keeping the nematocyst capsule in water at all times...
March 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/28197586/determination-of-the-temperature-dependent-cell-membrane-permeabilities-using-microfluidics-with-integrated-flow-and-temperature-control
#7
Cifeng Fang, Fujun Ji, Zhiquan Shu, Dayong Gao
We developed an integrated microfluidic platform for instantaneous flow and localized temperature control. The platform consisted of a flow-focusing region for sample delivery and a cross-junction region embedded with a microheater for cell trapping and localized temperature control by using an active feedback control system. We further used it to measure the membrane transport properties of Jurkat cells, including the osmotically inactive cell volume (Vb) and cell membrane permeabilities to water (Lp) and to cryoprotective agent (CPA) solutions (dimethyl sulfoxide (DMSO) in this study) (PS) at various temperatures (room temperature, 30 °C, and 37 °C)...
February 15, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28187046/effect-of-hydroxyethyl-starch-priming-on-the-systemic-inflammatory-response-and-lung-edema-following-cardiopulmonary-bypass-in-a-rat-model
#8
Yutaka Fujii, Takayuki Tanabe, Tsubasa Yamashiro, Mikiyasu Shirai, Yoshiaki Takewa, Eisuke Tatsumi
Cardiopulmonary bypass (CPB) preserves patients' lives during open heart surgery by providing sufficient oxygen delivery and blood supply to vital organs. However, previous studies have suggested that the interaction of hemodilution and vascular hyperpermeability induces tissue edema and an inflammatory response during CPB. In this study, we hypothesized that suppression of the systemic inflammatory response and tissue edema during CPB by a plasma substitute (hydroxyethyl starch: HES).Rats (450-500 g) were divided into a SHAM group (n=5), a Ringer's acetate CPB group (n=7), and an HES CPB group (n=7)...
February 7, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28123994/development-evaluation-and-influence-of-formulation-and-process-variables-on-in-vitro-performance-of-oral-elementary-osmotic-device-of-atenolol
#9
N Arjun, D Narendar, K Sunitha, K Harika, B Nagaraj
PURPOSE: Osmotic devices are the most promising strategy-based systems for controlled drug delivery. By optimizing formulation and processing parameters, possible to develop osmotic systems to deliver drugs at predetermined rate with high in vitro-in vivo correlation. The aim of the present investigation was to develop an oral elementary osmotic pump (EOP) of atenolol with zero-order or near zero-order drug release profile. MATERIALS AND METHODS: Differential scanning calorimetry and Fourier transform-infrared spectroscopy studies did not show any evidence of interaction between the drug and excipients...
October 2016: International Journal of Pharmaceutical Investigation
https://www.readbyqxmd.com/read/28034583/differential-hypertensive-protease-expression-in-the-thoracic-versus-abdominal-aorta
#10
Jean Marie Ruddy, Adam W Akerman, Denise Kimbrough, Elizabeth K Nadeau, Robert E Stroud, Rupak Mukherjee, John S Ikonomidis, Jeffrey A Jones
BACKGROUND: Hypertension (HTN), which is a major risk factor for cardiovascular morbidity and mortality, can drive pathologic remodeling of the macro- and microcirculation. Patterns of aortic pathology differ, however, suggesting regional heterogeneity of the pressure-sensitive protease systems triggering extracellular matrix remodeling in the thoracic (TA) and abdominal aortas (AA). This study tested the hypothesis that the expression of two major protease systems (matrix metalloproteinases [MMPs] and cathepsins) in the TA and AA would be differentially affected with HTN...
December 26, 2016: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28017887/controlled-nanoparticle-release-from-a-hydrogel-by-dna-mediated-particle-disaggregation
#11
C Nowald, B T Käsdorf, O Lieleg
For many pharmaceutical applications, it is important that different drugs are present in the human body at distinct time points. Typically, this is achieved by a sequential administration of different therapeutic agents. A much easier alternative would be to develop a drug delivery system containing a whole set of medically active compounds which are liberated in an orchestrated and controlled manner. Yet, such a controlled, sequential release of drugs from a carrier system that can be used in a physiological situation is difficult to achieve...
December 23, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28017126/recent-advances-in-transcranial-focused-ultrasound-fus-triggered-brain-delivery
#12
Nidhi Nainwal
Successful delivery of therapeutic agents in the brain is very challenging, which makes treatment of various brain disorders very difficult. One of the major causes of this difficulty is the presence of physiological barriers in the brain like blood brain barrier (BBB) and blood cerebro-spinal fluid (CSF) barrier. These barriers are very specific and restrict the entry of water soluble agents and ionized molecule. Only lipid soluble and small molecular size agents are allowed to enter into the brain. But there are several serious brain diseases in which the use of only conventional small molecular mass lipophilic drug is not effective...
December 22, 2016: Current Drug Targets
https://www.readbyqxmd.com/read/27978950/gene-therapy-with-angiotensin-1-9-preserves-left-ventricular-systolic-function-after-myocardial-infarction
#13
Caroline Fattah, Katrin Nather, Charlotte S McCarroll, Maria P Hortigon-Vinagre, Victor Zamora, Monica Flores-Munoz, Lisa McArthur, Lorena Zentilin, Mauro Giacca, Rhian M Touyz, Godfrey L Smith, Christopher M Loughrey, Stuart A Nicklin
BACKGROUND: Angiotensin-(1-9) [Ang-(1-9)] is a novel peptide of the counter-regulatory axis of the renin-angiotensin-aldosterone system previously demonstrated to have therapeutic potential in hypertensive cardiomyopathy when administered via osmotic mini-pump. Here, we investigate whether gene transfer of Ang-(1-9) is cardioprotective in a murine model of myocardial infarction (MI). OBJECTIVES: The authors evaluated effects of Ang-(1-9) gene therapy on myocardial structural and functional remodeling post-infarction...
December 20, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27916694/regenerated-cellulose-capsules-for-controlled-drug-delivery-part-iv-in-vitro-evaluation-of-novel-self-pore-forming-regenerated-cellulose-capsules
#14
Bhavik Bhatt, Vijay Kumar
In the present work, the release mechanisms of active pharmaceutical ingredients (APIs) enclosed in self-pore forming regenerated cellulose (RC) two-piece hard shell capsules are described. The RC capsules were fabricated using a modified dip-coating approach, which yielded an assembled dosage form that was equivalent in size and shape to a conventional gelatin two-piece hard shell capsule. Drug release characteristics from RC capsules were evaluated using potassium chloride, diphenhydramine hydrochloride, tramadol hydrochloride, niacinamide, acetaminophen and ketoprofen as model APIs...
January 15, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27879551/no-superiority-of-treatment-with-osmotic-controlled-release-oral-delivery-system-methylphenidate-over-short-medium-acting-methylphenidate-preparations-in-the-rate-and-timing-of-injuries-in-children-with-attention-deficit-hyperactivity-disorder
#15
Pavel Golubchik, Arad Kodesh, Abraham Weizman
OBJECTIVES: Methylphenidate (MPH) treatment in patients with attention-deficit/hyperactivity disorder (ADHD) is reported to reduce the risk for injuries. In the present study, the rate and timing of injuries were compared among the various MPH preparations (4 and 6-8 vs 12 hour-acting) in children with ADHD. METHODS: This real-world retrospective study covered the years 2011 to 2013. Participants included 2042 youngsters (aged 4-18 years, 13.01 ± 3.2 years; 71...
January 2017: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/27860265/osmogen-mediated-one-step-technique-of-fabricating-hollow-microparticles-for-encapsulation-and-delivery-of-bioactive-molecules
#16
Sharad Kharel, Wei Li Lee, Xuan Yi Lee, Say Chye Joachim Loo
Microparticulate systems composed of biodegradable polymers, such as poly(d,l-lactic-co-glycolic acid) (PLGA), are widely used for controlled release of bioactive molecules. However, the acidic microenvironment within these microparticles, as they degrade, has been reported to perturb the configuration of most encapsulated proteins. In addition, these polymer particles are also reported to suffer from unrealistically slow and incomplete release of proteins. To address these drawbacks, hollow PLGA microparticles are fabricated through a novel one-step oil-in-water emulsion solvent evaporation technique, by capitalizing on the osmotic property of an osmogen...
November 16, 2016: Macromolecular Bioscience
https://www.readbyqxmd.com/read/27837534/elastic-liposomes-for-topical-and-transdermal-drug-delivery
#17
Heather A E Benson
Elastic liposomes have been developed and evaluated as novel topical and transdermal delivery systems. They share some similarities to conventional liposomes but their composition is designed to confer flexibility and elasticity in the lipid bilayer structure. Elastic liposomes are applied non-occluded to the skin and are reported to permeate through the stratum corneum lipid lamellar regions as a result of the hydration or osmotic force in the skin. They have been investigated as drug carriers for a range of small molecules, peptides, proteins, and vaccines, both in vitro and in vivo...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27822929/once-daily-oros-hydromorphone-for-management-of-cancer-pain-an-open-label-multi-center-non-interventional-study
#18
MULTICENTER STUDY
Cheol Kyu Park, Hyun Wook Kang, In Jae Oh, Young Chul Kim, Yeo Kyeoung Kim, Kook Joo Na, Sung Ja Ahn, Tae Ok Kim, Young Jin Choi, Geun Am Song, Min Ki Lee
Extended-release osmotic extended-release oral delivery system (OROS) hydromorphone is a strong synthetic opioid designed to maintain a constant blood concentration by once daily dosing. The objective of this observational study was to investigate the clinical usefulness of OROS hydromorphone in patients with cancer pain of moderate to severe intensity. Patients with cancer pain who required strong opioids were administered with OROS hydromorphone for 4 weeks. We assessed changes in pain intensity using a numerical rating scale (NRS) as well as levels of sleep disturbance, breakthrough pain, end-of-dose failure, patient satisfaction, and overall assessment of drug effectiveness based on investigator evaluation...
December 2016: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/27822054/impact-of-sodium-glucose-cotransporter-2-inhibitors-on-blood-pressure
#19
REVIEW
James W Reed
SGLT2 inhibitors are glucose-lowering agents used to treat type 2 diabetes mellitus (T2DM). These agents target the kidney to promote urinary glucose excretion, resulting in improved blood glucose control. SGLT2-inhibitor therapy is also associated with weight loss and blood pressure (BP) lowering. Hypertension is a common comorbidity in patients with T2DM, and is associated with excess morbidity and mortality. This review summarizes data on the effect of SGLT2 inhibitors marketed in the US (namely canagliflozin, dapagliflozin, or empagliflozin) on BP in patients with T2DM...
2016: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/27783857/magnocellular-neurons-and-posterior-pituitary-function
#20
Colin H Brown
The posterior pituitary gland secretes oxytocin and vasopressin (the antidiuretic hormone) into the blood system. Oxytocin is required for normal delivery of the young and for delivery of milk to the young during lactation. Vasopressin increases water reabsorption in the kidney to maintain body fluid balance and causes vasoconstriction to increase blood pressure. Oxytocin and vasopressin secretion occurs from the axon terminals of magnocellular neurons whose cell bodies are principally found in the hypothalamic supraoptic nucleus and paraventricular nucleus...
September 15, 2016: Comprehensive Physiology
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