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TNF-alpha and obesity

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https://www.readbyqxmd.com/read/27917214/treadmill-walking-exercise-modulates-bone-mineral-status-and-inflammatory-cytokines-in-obese-asthmatic-patients-with-long-term-intake-of-corticosteroids
#1
Shehab M Abd El-Kader, Osama H Al-Jiffri, Eman M Ashmawy, Riziq Allah M Gaowgzeh
BACKGROUND: Obesity and asthma are an important public health problem in Saudi Arabia. An increasing body of data supports the hypothesis that obesity is a risk factor for asthma. Asthma appears to be associated with low bone mineral density (BMD) due to long-term use of corticosteroids. Studies recently showed that weight bearing exercise training can increase mineral bone density, reduce weight and improve metabolic control. OBJECTIVE: The present study aimed to measure the effects of treadmill walking exercises on bone mineral status and inflammatory cytokines in obese asthmatic patients treated with long term intake of corticosteroids...
September 2016: African Health Sciences
https://www.readbyqxmd.com/read/27917205/impact-of-weight-loss-on-oxidative-stress-and-inflammatory-cytokines-in-obese-type-2-diabetic-patients
#2
Shehab M Abd El-Kader, Mohammed H Saiem Al-Dahr
BACKGROUND: Type 2 diabetes mellitus is associated with abnormal markers of inflammatory cytokines and oxidative stress markers. Although, these abnormalities could be modulated with weight reduction; there is limitation in clinical studies that have addressed the beneficial effects of weight reduction in modulating biomarkers of inflammatory cytokines and oxidative stress for obesity associated with type 2 diabetes mellitus. OBJECTIVE: This study was designed to detect the effects of weight loss on the inflammatory cytokines, oxidative stress markers in obese type 2 diabetic patients...
September 2016: African Health Sciences
https://www.readbyqxmd.com/read/27904616/effect-of-folic-acid-and-metformin-on-insulin-resistance-and-inflammatory-factors-of-obese-children-and-adolescents
#3
Elham Hashemi Dehkordi, Farnaz Sattari, Abolfazl Khoshdel, Karamali Kasiri
BACKGROUND: Considering the increasing trend of obesity, especially in developing countries such as Iran, and the role of inflammatory factors and insulin resistance (IR) in the occurrence of obesity-related complications as well as the safety of some agents such as folic acid and metformin, this clinical trial was designed to investigate the effect of metformin and folic acid on inflammatory factors and IR among obese children. MATERIALS AND METHODS: In this randomized, double-blind, controlled clinical trial study, sixty obese children aged 6-12 years were enrolled...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/27864335/effects-of-maternal-obesity-on-placental-function-and-fetal-development
#4
Kristy R Howell, Theresa Powell
Obesity has reached epidemic proportions and pregnancies in obese mothers have increased risk for complications including gestational diabetes, hypertensive disorders, preterm birth and caesarian section. Children born to obese mothers are at increased risk of obesity and metabolic disease and are susceptible to develop neuropsychiatric and cognitive disorders. Changes in placental function not only play a critical role in the development of pregnancy complications but may also be involved in linking maternal obesity to long-term health risks in the infant...
November 18, 2016: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/27843953/considerations-for-defining-cytokine-dose-duration-and-milieu-that-are-appropriate-for-modeling-chronic-low-grade-inflammation-in-type-2-diabetes
#5
REVIEW
Craig S Nunemaker
Proinflammatory cytokines have been implicated in the pathophysiology of both type 1 diabetes (T1D) and type 2 diabetes (T2D). T1D is an autoimmune disease involving the adaptive immune system responding to pancreatic beta-cells as antigen-presenting cells. This attracts immune cells that surround pancreatic islets (insulitis) and secrete cytokines, such as IL-1beta, IFN-gamma, and TNF-alpha, in close proximity to pancreatic beta-cells. In contrast, there is little evidence for such a focused autoimmune response in T2D...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/27795608/cytokine-profile-in-chronic-periodontitis-patients-with-and-without-obesity-a-systematic-review-and-meta-analysis
#6
REVIEW
Zohaib Akram, Tariq Abduljabbar, Mohamed Ibrahim Abu Hassan, Fawad Javed, Fahim Vohra
To investigate the cytokine profile as biomarkers in the gingival crevicular fluid (GCF) of chronic periodontitis (CP) patients with and without obesity, MEDLINE/PubMed, EMBASE, ScienceDirect, and SCOPUS databases were combined with handsearching of articles published from 1977 up to May 2016 using relevant MeSH terms. Meta-analyses were conducted separately for each of the cytokines: resistin, adiponectin, TNF-α, leptin, IL-6, IL-8, and IL-1β. Forest plots were produced reporting standardized mean difference of outcomes and 95% confidence intervals...
2016: Disease Markers
https://www.readbyqxmd.com/read/27759977/association-of-the-rs9939609-gene-variant-in-fto-with-insulin-resistance-cardiovascular-risk-factor-and-serum-adipokine-levels-in-obese-patients
#7
Daniel A De Luis, Rocío Aller, Olatz Izaola, David Primo, E Romero
INTRODUCTION: The aim of our study was to analyze the relationship of the rs9939609 FTO gene polymorphism with insulin resistance and serum adipokine levels. MATERIAL AND METHODS: A population of 610 patients with obesity was analyzed in a cross sectional design. Weight, blood pressure, basal glucose, c-reactive protein (CRP), insulin, insulin resistance (HOMA), lipid profile and adipocytokines (leptin, adiponectin, resistin, TNF alpha, and interleukin 6) levels were measured...
September 20, 2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/27751827/response-of-gut-microbiota-and-inflammatory-status-to-bitter-melon-momordica-charantia-l-in-high-fat-diet-induced-obese-rats
#8
Juan Bai, Ying Zhu, Ying Dong
ETHNOPHARMACOLOGICAL RELEVANCE: Bitter melon (Momordica charantia L.) is rich in a variety of biologically active ingredients, and has been widely used in traditional Chinese medicine (TCM) to treat various diseases, including type 2 diabetes and obesity. AIM OF THE STUDY: We aimed to investigate how bitter melon powder (BMP) could affect obesity-associated inflammatory responses to ameliorate high-fat diet (HFD)-induced insulin resistance, and investigated whether its anti-inflammatory properties were effected by modulating the gut microbiota...
October 14, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27746742/molecular-mechanisms-of-obesity-induced-osteoporosis-and-muscle-atrophy
#9
Bipradas Roy, Mary E Curtis, Letimicia S Fears, Samuel N Nahashon, Hugh M Fentress
Obesity and osteoporosis are two alarming health disorders prominent among middle and old age populations, and the numbers of those affected by these two disorders are increasing. It is estimated that more than 600 million adults are obese and over 200 million people have osteoporosis worldwide. Interestingly, both of these abnormalities share some common features including a genetic predisposition, and a common origin: bone marrow mesenchymal stromal cells. Obesity is characterized by the expression of leptin, adiponectin, interleukin 6 (IL-6), interleukin 10 (IL-10), monocyte chemotactic protein-1 (MCP-1), tumor necrosis factor-alpha (TNF-α), macrophage colony stimulating factor (M-CSF), growth hormone (GH), parathyroid hormone (PTH), angiotensin II (Ang II), 5-hydroxy-tryptamine (5-HT), Advance glycation end products (AGE), and myostatin, which exert their effects by modulating the signaling pathways within bone and muscle...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27741107/inflammatory-cytokines-in-pediatric-obstructive-sleep-apnea
#10
Yu-Shu Huang, Christian Guilleminault, Fang-Ming Hwang, Chuan Cheng, Cheng-Hui Lin, Hsueh-Yu Li, Li-Ang Lee
Pediatric obstructive sleep apnea (OSA) is associated with chronic systemic inflammation and with cognitive impairments. This study aimed to investigate the status of proinflammatory cytokines, particularly interleukin 17 (IL-17) and interleukin 23 (IL-23) and cognition in pediatric OSA.Controls and OSA children participated in the study. Exclusion criteria were adenotonsillectomy, heart, neurological and severe psychiatric diseases, craniofacial syndromes, and obesity. Polysomnogram was followed by serum testing for inflammatory markers and neurocognitive tests such as continuous performance task (CPT) and Wisconsin card sorting test, questionnaires, analyses of plasma high-sensitivity C-reactive protein (HS-CRP), tumor necrosis factor alpha (TNF-α), interleukin 1 (IL-1), interleukin 6 (IL-6), IL-17, and IL-23...
October 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27690087/a-trypsin-inhibitor-from-tamarind-reduces-food-intake-and-improves-inflammatory-status-in-rats-with-metabolic-syndrome-regardless-of-weight-loss
#11
Fabiana M C Carvalho, Vanessa C O Lima, Izael S Costa, Amanda F Medeiros, Alexandre C Serquiz, Maíra C J S Lima, Raphael P Serquiz, Bruna L L Maciel, Adriana F Uchôa, Elizeu A Santos, Ana H A Morais
Trypsin inhibitors are studied in a variety of models for their anti-obesity and anti-inflammatory bioactive properties. Our group has previously demonstrated the satietogenic effect of tamarind seed trypsin inhibitors (TTI) in eutrophic mouse models and anti-inflammatory effects of other trypsin inhibitors. In this study, we evaluated TTI effect upon satiety, biochemical and inflammatory parameters in an experimental model of metabolic syndrome (MetS). Three groups of n = 5 male Wistar rats with obesity-based MetS received for 10 days one of the following: (1) Cafeteria diet; (2) Cafeteria diet + TTI (25 mg/kg); and (3) Standard diet...
2016: Nutrients
https://www.readbyqxmd.com/read/27605969/weight-loss-improves-biomarkers-endothelial-function-and-systemic-inflammation-in-obese-postmenopausal-saudi-women
#12
Shehab Mahmoud Abd El-Kader, Mohammed H Saiem Al-Dahr
BACKGROUND: Although postmenopausal associated disorders are important public health problems worldwide, to date limited studies evaluated the endothelial function and systemic inflammation response to weight loss in obese postmenopausal women. OBJECTIVE: This study was done to evaluate the endothelial function and systemic inflammation response to weight loss in obese postmenopausal Saudi women. MATERIAL AND METHODS: Eighty postmenopausal obese Saudi women (mean age 52...
June 2016: African Health Sciences
https://www.readbyqxmd.com/read/27590487/c1q-tnf-related-protein-3-expression-and-effects-on-adipocyte-differentiation-of-3t3-l1-cells
#13
Hiroki Nishimoto, Akihiro Yamamoto, Souhei Furukawa, Satoshi Wakisaka, Takashi Maeda
Adipose tissue-derived adipokines influence a number of organs critical for energy homeostasis and metabolism. One of the most extensively studied adipokines is adiponectin, which exerts anti-diabetic, anti-inflammatory and anti-atherogenic functions on various cell types. CTRP3, a paralog of adiponectin, is a member of the C1q and tumor necrosis factor-related protein (CTRP) superfamily. CTRP3 reduces hepatic triglyceride levels in diet-induced obese (DIO) mice. However, the physiological role of CTRP3 in adipocytes is largely unknown...
September 3, 2016: Cell Biology International
https://www.readbyqxmd.com/read/27582585/association-between-serum-vitamin-d-level-and-glycemic-and-inflammatory-markers-in-non-obese-patients-with-type-2-diabetes
#14
Fatemeh Haidari, Mehrnoosh Zakerkish, Majid Karandish, Azadeh Saki, Sakineh Pooraziz
BACKGROUND: Low serum 25-hydroxy vitamin D (25(OH)D) has been shown to correlate with an increased risk of type 2 diabetes mellitus (T2DM). The objective of this study was to investigate the association between serum 25(OH)D and glycemic and inflammatory markers in non-obese patients with T2DM. METHODS: Eighty-four non-obese patients with T2DM were recruited in this cross-sectional study. Demographic, anthropometric, and dietary information was obtained from all the participants...
September 2016: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/27569685/proinflammatory-environment-and-role-of-tnf-%C3%AE-in-endometrial-function-of-obese-women-having-polycystic-ovarian-syndrome-pcos
#15
L Oróstica, I Astorga, F Plaza-Parrochia, C Vera, V García, R Carvajal, F Gabler, C Romero, M Vega
BACKGROUND/OBJECTIVES: A high percentage of women having PCOS exhibit hyperinsulinemia and obesity. Transforming necrosis factor-alpha (TNF-α) is an adipokine that increases in obesity and negatively affects insulin action in several tissues, including the endometrium. In fact, it has been reported that insulin signaling is altered in the endometrium of PCOS women, affecting its reproductive function. The aim of this study was to determine the pro-inflammatory environment and TNF-α signaling in endometrium from obese women with PCOS, and also to evaluate the effect of TNF-α on endometrial cell energy homeostasis...
August 29, 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/27569681/the-individual-and-combined-effects-of-obesity-and-ageing-induced-systemic-inflammation-on-human-skeletal-muscle-properties
#16
R M Erskine, D J Tomlinson, C I Morse, K Winwood, P Hampson, J M Lord, G L Onambélé
BACKGROUND/OBJECTIVES: The purpose of this study was to determine whether circulating pro-inflammatory cytokines, elevated with increased fat mass and ageing, were associated with muscle properties in young and older people with variable adiposity. SUBJECTS/METHODS: Seventy-five young (18-49 yrs) and 67 older (50-80 yrs) healthy, untrained men and women (BMI: 17-49 kg/m(2)) performed isometric and isokinetic plantar flexor maximum voluntary contractions (MVCs)...
August 29, 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/27513494/-not-available
#17
Daniel A De Luis, Rocío Aller, Olatz Izaola, Enrique Romero
BACKGROUND: Mutation analysis has identified a G-> A transition in the promoter region of TNF-alpha gene at position -308 (rs1800629). OBJECTIVE: The aim of our study was to investigate the influence of polymorphism in -308 GA promoter variant of the TNF alpha gene on metabolic response and weight loss secondary to two hypocaloric diets. METHOD: A sample of 283 obese subjects was enrolled in a consecutive prospective way. In the basal visit, patients were randomly allocated during 9 months to diet HP (high protein/low carbohydrate hypocaloric diet) and diet S (standard hypocaloric diet)...
2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/27508759/-op-5d-03-chronic-inflammation-during-pregnancy-influence-the-progression-of-early-sympathetic-mediated-hypertension-in-offspring-arising-from-maternal-obesity
#18
A Samuelsson, J M Pombo, C W Coen, C Mallard, P Gressens, L Poston
OBJECTIVE: Mounting evidence suggests that an overactive immune response during pregnancy may alter the development of the central nervous system in the foetus. An increased concentration of pro-inflammatory cytokines has been demonstrated in amniotic fluid of obese pregnancy. This study investigate if low-chronic inflammation, during brain development may have enduring effects on hypothalamic immune response leading to autonomic disturbances and sympathetic mediated hypertension arising from maternal obesity...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27444466/-not-available
#19
Daniel A De Luis, Rocío Aller, Olatz Izaola, Enrique Romero
BACKGROUND: Mutation analysis has identified a G-> A transition in the promoter region of TNF-alpha gene at position -308 (rs1800629). OBJECTIVE: The aim of our study was to investigate the influence of polymorphism in -308 GA promoter variant of the TNF alpha gene on metabolic response and weight loss secondary to two hypocaloric diets. METHOD: A sample of 283 obese subjects was enrolled in a consecutive prospective way. In the basal visit, patients were randomly allocated during 9 months to diet HP (high protein/low carbohydrate hypocaloric diet) and diet S (standard hypocaloric diet)...
2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/27405372/effect-of-plant-based-diets-on-obesity-related-inflammatory-profiles-a-systematic-review-and-meta-analysis-of-intervention-trials
#20
F Eichelmann, L Schwingshackl, V Fedirko, K Aleksandrova
Plant-based dietary interventions have been proposed to reduce obesity induced chronic low-grade inflammation and hence prevent chronic disease risk; however, human evidence remains unclear. This systematic review and meta-analysis of intervention trials aimed to assess the effect of plant-based diets on obesity-related inflammatory biomarker profiles. Medline, EMBASE and Cochrane Central Register of Controlled Trials (CENTRAL) were searched for articles published until January 2016 and mean differences in biomarkers of inflammatory status were assessed for: C-reactive protein (CRP), interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-ɑ), soluble intercellular adhesion molecule 1 (sICAM), leptin, adiponectin and resistin...
November 2016: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
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