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TNF-alpha and obesity

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https://www.readbyqxmd.com/read/29246653/myostatin-and-adipokines-the-role-of-the-metabolically-unhealthy-obese-phenotype-in-muscle-function-and-aerobic-capacity-in-young-adults
#1
Lívia Pinheiro Carvalho, Renata Pedrolongo Basso-Vanelli, Luciana Di Thommazo-Luporini, Renata Gonçalves Mendes, Manoel Carneiro Oliveira-Junior, Rodolfo de Paula Vieira, José Carlos Bonjorno-Junior, Cláudio Ricardo Oliveira, Rafael Luporini, Audrey Borghi-Silva
Obesity is often associated with metabolic disorders. However, some obese people can present a metabolically healthy phenotype, despite having excessive body fat. Obesity-related cytokines, such as myostatin (MSTN), leptin (LP) and adiponectin (ADP) appear to be key factors for the regulation of muscle and energy metabolism. Our aim was to compare lipid, glucose-insulin and inflammatory (tumor necrosis factor alpha; TNF-α) profiles, muscle function, energy expenditure and aerobic capacity between healthy normal-weight (NW) adults, metabolically healthy obese (MHO) and metabolically unhealthy obese (MUHO) adults; to study the associations between these outcomes and the cytokines MSTN, ADP, LP; and to establish cutoffs for MSTN and LP/ADP to identify the MUHO phenotype...
December 12, 2017: Cytokine
https://www.readbyqxmd.com/read/29229313/emerging-role-of-adipocytokines-in-type-2-diabetes-as-mediators-of-insulin-resistance-and-cardiovascular-disease
#2
REVIEW
Ravindran Jaganathan, Rajeswari Ravindran, Sugapriya Dhanasekaran
Adipose tissue is an enormously active endocrine organ, secreting various hormones, such as adiponectin, leptin, resistin and visfatin, together with classical cytokines, such as tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6). All these adipocytokines plays significant roles in the regulation of energy metabolism, glucose and lipid metabolism, reproduction, cardiovascular function and immunity. Adipocytokines are significantly regulated by nutritional status and can directly influence other organ systems, including brain, liver and skeletal muscle...
December 8, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/29222347/pioglitazone-inhibits-periprostatic-white-adipose-tissue-inflammation-in-obese-mice
#3
Miki Miyazawa, Kotha Subbaramaiah, Priya Bhardwaj, Xi K Zhou, Hanhan Wang, Domenick J Falcone, Dilip D Giri, Andrew J Dannenberg
Obesity is associated with an increased incidence of high-grade prostate cancer (PC) and poor prognosis for PC patients. Recently, we showed that obesity-related periprostatic white adipose tissue (WAT) inflammation, characterized by crown-like structures (CLS) consisting of dead or dying adipocytes surrounded by macrophages, was associated with high-grade PC. It's possible, therefore, that agents that suppress periprostatic WAT inflammation will alter the development or progression of PC. Pioglitazone, a ligand of PPARγ is used to treat diabetes and possesses anti-inflammatory properties...
December 8, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/29174028/inflammation-in-metabolically-healthy-and-metabolically-abnormal-adolescents-the-helena-study
#4
E M González-Gil, C Cadenas-Sanchez, J Santabárbara, G Bueno-Lozano, I Iglesia, M González-Gross, D Molnar, F Gottrand, S De Henauw, A Kafatos, K Widhalm, Y Manios, A Siani, F Amaro-Gahete, A I Rupérez, D Cañada, L Censi, M Kersting, J Dallongeville, A Marcos, F B Ortega, L A Moreno
BACKGROUND AND AIMS: Inflammation may influence the cardio-metabolic profile which relates with the risk of chronic diseases. This study aimed to assess the inflammatory status by metabolic health (MH)/body mass index (BMI) category and to assess how inflammatory markers can predict the cardio-metabolic profile in European adolescents, considering BMI. METHODS AND RESULTS: A total of 659 adolescents (295 boys) from a cross-sectional European study were included...
October 13, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29165098/effects-of-olive-oil-on-tnf-%C3%AE-and-il-6-in-humans-implication-in-obesity-and-frailty
#5
Nagendra Sastry Yarla, Angela Polito, Ilaria Peluso
BACKGROUND AND OBJECTIVE: Tumor necrosis factor-alpha (TNF)-α and interleukin (IL)-6 are important mediators of chronic low-grade systemic inflammation. The latter plays a central role in several obesity-related pathologies, such as diabetes, metabolic syndrome and cardiovascular diseases. Besides, these cytokines have been also implicated in geriatric and cancer-induced anorexia, cachexia, sarcopenia and frailty. Potential interventions for both obesity and frailty include dietary advice and nutraceuticals...
November 20, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29124887/association-between-metabolic-syndrome-and-gingival-inflammation-in-obese-children
#6
K Kâ, M-C Rousseau, S D Tran, M Henderson, B Nicolau
BACKGROUND AND OBJECTIVE: Our previous work showed a positive association between metabolic syndrome (MetS) and gingival crevicular fluid (GCF) tumour necrosis factor-alpha (TNF-α) in a sample of obese and non-obese children. However, whether this association persists among obese children is unknown. We aim to investigate the extent to which MetS is associated with GCF TNF-α level among obese children. METHODOLOGY: We performed a cross-sectional analysis using data from visit 1 of the QUebec Adipose and Lifestyle InvesTigation in Youth cohort...
November 10, 2017: International Journal of Dental Hygiene
https://www.readbyqxmd.com/read/29114515/responses-of-inflammatory-cytokines-following-moderate-intensity-walking-exercise-in-overweight-or-obese-individuals
#7
Yunsuk Koh, Kyung-Shin Park
This study investigated the effects of a 4-week moderate intensity walking exercise on the levels of C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), and adiponectin in overweight or obese individuals. Twenty-seven (13 men and 14 women) physically inactive, over-weight or obese (body mass index>25.0 kg/m(2)) individuals participated in the study. Each participant was randomly assigned to either exercise (EX; n=15) or control (CON; n=12) group. The EX group performed moderate intensity walking exercise on a treadmill for 60 min at 70% of maximal heart rate for 4 weeks (3 days/wk)...
August 2017: Journal of Exercise Rehabilitation
https://www.readbyqxmd.com/read/29113135/nonalcoholic-fatty-liver-disease-is-exacerbated-in-high-fat-diet-fed-gnotobiotic-mice-by-colonization-with-the-gut-microbiota-from-patients-with-nonalcoholic-steatohepatitis
#8
Chien-Chao Chiu, Yung-Hao Ching, Yen-Peng Li, Ju-Yun Liu, Yen-Te Huang, Yi-Wen Huang, Sien-Sing Yang, Wen-Ching Huang, Hsiao-Li Chuang
Nonalcoholic fatty liver disease (NAFLD) is a serious liver disorder associated with the accumulation of fat and inflammation. The objective of this study was to determine the gut microbiota composition that might influence the progression of NAFLD. Germ-free mice were inoculated with feces from patients with nonalcoholic steatohepatitis (NASH) or from healthy persons (HL) and then fed a standard diet (STD) or high-fat diet (HFD). We found that the epididymal fat weight, hepatic steatosis, multifocal necrosis, and inflammatory cell infiltration significantly increased in the NASH-HFD group...
November 6, 2017: Nutrients
https://www.readbyqxmd.com/read/29111391/short-term-effects-of-adjunctive-antimicrobial-photodynamic-therapy-in-obese-patients-with-chronic-periodontitis-a-randomized-controlled-clinical-trial
#9
Fahim Vohra, Zohaib Akram, Ishfaq A Bukhari, Saeed A Sheikh, Fawad Javed
BACKGROUND: The aim of the present study was to assess the effect of antimicrobial photodynamic therapy (aPDT) as an adjunct to scaling and root planing (SRP) on clinical periodontal and immunological parameters in obese patients with chronic periodontitis (CP). METHODS: Fifty-three obese with CP patients were divided into 2 groups receiving aPDT with SRP and SRP only respectively. Full-mouth plaque index (PI), bleeding on probing (BOP), pocket depth (PD) and clinical attachment level (CAL) were assessed at baseline, 6 and 12 weeks post-therapy...
October 27, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29090232/clinical-significance-of-serum-il-6-and-tnf-%C3%AE-levels-in-patients-with-metabolic-syndrome
#10
Mojgan Mohammadi, Mohammad Hossein Gozashti, Majid Aghadavood, Mohammad Reza Mehdizadeh, Mohammad Mahdi Hayatbakhsh
BACKGROUND: Several components of metabolic syndrome (MetS) facilitate its diagnosis, including abdominal obesity, hyperlipidemia, high blood pressure, and insulin resistance. The production of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) seem to be associated with MetS components. The aim of this study was to evaluate the correlation between IL-6 and TNF-α serum levels with MetS and its components. METHODS: This case-control study investigated 250 subjects, comprising 125 healthy controls from the Kerman Blood Transfusion Organization and 125 MetS patients...
October 2017: Reports of Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/29056829/low-circulating-trail-levels-are-associated-with-increase-of-resistin-and-lipocalin-2-ngal-adipokines-in-postmenopausal-women
#11
Veronica Tisato, Paola Secchiero, Gloria Bonaccorsi, Carlo Bergamini, Pantaleo Greco, Giorgio Zauli, Carlo Cervellati
OBJECTIVE: Tumor necrosis factor- (TNF-) related apoptosis-inducing ligand (TRAIL) is attracting attention for its role in the physiopathology of metabolic disease/diabetes. Evidence suggests that it might protect against metabolic abnormalities driven by obesity-induced dysregulated secretion of adipokines, but this role of TRAIL has not yet been fully established. On this basis, we aimed to investigate the potential association between TRAIL and adipokine levels in a cohort of subjects in which age/gender/hormonal interferences were excluded...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28989568/expression-of-matrix-metalloproteinase-11-is-increased-under-conditions-of-insulin-resistance
#12
Biagio Arcidiacono, Eusebio Chiefari, Anna Elisa Laria, Sebastiano Messineo, Francesco Luciano Bilotta, Domenico Britti, Daniela Patrizia Foti, Anna Foryst-Ludwig, Ulrich Kintscher, Antonio Brunetti
AIM: To investigate matrix metalloproteinase-11 (MMP-11) expression in adipose tissue dysfunction, using in vitro and in vivo models of insulin resistance. METHODS: Culture of mouse 3T3-L1 preadipocytes were induced to differentiation into mature 3T3-L1 adipocytes. Cellular insulin resistance was induced by treating differentiated cultured adipocytes with hypoxia and/or tumor necrosis factor (TNF)-α, and transcriptional changes were analyzed in each condition thereafter...
September 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28978869/vitamin-d-receptor-gene-variation-dietary-intake-and-bone-mineral-density-in-obese-women-a-cross-sectional-study
#13
Sajjad Moradi, Leila Khorrami-Nezhad, Zhila Maghbooli, Banafshe Hosseini, Seyed Ali Keshavarz, Khadijeh Mirzaei
Osteoporosis and fragility fractures have been regarded as important public health concerns. We investigated their possible association with vitamin D receptor (VDR) FOK1 polymorphisms (rs10735810) and dietary parameters such as calcium and vitamin D intake. A total of 264 Iranian obese women (BMI>30 kg/m(2)) were categorized based on the FOK1 genotype and divided into two groups: group one with the FF genotype (n=184) and the f allele carrier group with the Ff or ff genotype (n=80). The body composition, dietary intake and bone mineral density were assessed for all cases...
2017: Journal of Nutritional Science and Vitaminology
https://www.readbyqxmd.com/read/28933980/panduratin-a-prevents-tumor-necrosis-factor-alpha-induced-muscle-atrophy-in-l6-rat-skeletal-muscle-cells
#14
Bo-Kyung Sa, Changhee Kim, Mi-Bo Kim, Jae-Kwan Hwang
Panduratin A, a prenylated chalcone compound, has anti-obesity, anti-bacterial, anti-cancer, anti-inflammatory, and anti-oxidative activities. However, its preventive effect on muscle atrophy has not been studied. The purpose of this study was to evaluate the inhibitory effect of panduratin A on muscle atrophy and to investigate its molecular mechanisms in tumor necrosis factor-alpha (TNF-α)-treated L6 rat skeletal muscle cells. Panduratin A restored the myotube diameter reduced by TNF-α. At the molecular level, panduratin A elevated phosphatidylinositol 3 kinase/Akt/mammalian target of rapamycin pathway and stimulated the MyoD and myogenin mRNA expression decreased by TNF-α...
September 21, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28923316/different-combinations-of-maternal-and-postnatal-diet-are-reflected-in-changes-of-hepatic-parenchyma-and-hepatic-tnf-alpha-expression-in-male-rat-offspring
#15
Željka Perić Kačarević, Anđela Grgić, Darija Šnajder, Nikola Bijelić, Tatjana Belovari, Olga Cvijanović, Valerija Blažičević, Radivoje Radić
Obesity is related to increased TNF-alpha production in different tissues. TNF-alpha is connected to mitochondrial dysfunction in the liver and also development of fatty infiltration of the liver. Also, postnatal change from normal to high-fat diet causes a significant increase in TNF-alpha serum levels. The aim of this research was to determine how maternal diet and switching male offspring to a different dietary regime after lactation influences rat liver. Ten female Sprague Dawley rats at nine weeks of age were randomly divided in two groups and fed either standard laboratory chow or high-fat diet during six weeks, and then mated with the same male subject...
September 15, 2017: Acta Histochemica
https://www.readbyqxmd.com/read/28894050/compounds-of-psoriasis-with-obesity-and-overweight
#16
Agnieszka Owczarczyk-Saczonek, Waldemar Placek
Many epidemiological studies have confirmed the relationship of obesity and psoriasis, and it is believed that obesity is an independent risk factor for its development and is associated with a worse prognosis. Furthermore, the reduction of body weight, using low-calorie diet combined with exercise, reduces the severity of psoriasis.Visceral adipose tissue is the largest endocrine organ, producing proinflammatory cytokines (TNF-α, IL-6, IL-17) and adipokines (adiponectin, omentin, chemerin). They participate in the development of dyslipidemia, insulin resistance, diabetes, and consequently of the cardiovascular diseases...
August 24, 2017: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/28855812/tnf-alpha-308g-a-and-238g-a-polymorphisms-and-its-protein-network-associated-with-type-2-diabetes-mellitus
#17
Kaiser Jamil, Archana Jayaraman, Javeed Ahmad, Sindhu Joshi, Shiva Kumar Yerra
Several reports document the role of tumor necrosis factor alpha (TNF-α) and lipid metabolism in the context of acute inflammation as a causative factor in obesity-associated insulin resistance and as one of the causative parameter of type 2 diabetes mellitus (T2DM). Our aim was to investigate the association between -308G/A and -238G/A polymorphisms located in the promoter region of the TNF-α gene in T2DM in the Indian population with bioinformatics analysis of TNF-α protein networking with an aim to find new target sites for the treatment of T2DM...
September 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/28839361/ethanolic-fraction-of-terminalia-tomentosa-attenuates-biochemical-and-physiological-derangements-in-diet-induced-obese-rat-model-by-regulating-key-lipid-metabolizing-enzymes-and-adipokines
#18
Balaji Meriga, Parim Brahma Naidu, Ganjayi Muniswamy, Gen Hanuma Kumar, Ramavat Ravindar Naik, Suresh Pothani
The prevalence of overweight-obesity and associated comorbidities have reached alarming levels necessitating the need to explore effective therapeutics. In the present work, we demonstrated the promising antiobesity activity of ethanolic fraction of Terminalia tomentosa bark (EFTT) in diet induced obese rat model. High Fat Diet (HFD)-fed obese rats were orally administered with EFTT (50, 100 and 200 mg/kg body weight). Changes in body weight, body composition, bone mineral concentration, bone mineral density, plasma glucose, insulin, leptin, adiponectin, circulatory and tissue lipid profiles, and the activities of liver antioxidant enzymes, key lipid metabolic enzymes and mRNA expressions of fatty acid synthase (FAS), peroxisome proliferator-activated receptor gamma (PPAR-γ), leptin and tumor necrosis factor alpha (TNF-α) were assessed in experimental rats in the presence and absence of EFTT...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28793265/a-hepatic-gabp-ampk-axis-links-inflammatory-signaling-to-systemic-vascular-damage
#19
Katharina Niopek, Bilgen Ekim Üstünel, Susanne Seitz, Minako Sakurai, Annika Zota, Frits Mattijssen, Xiaoyue Wang, Tjeerd Sijmonsma, Yvonne Feuchter, Anna M Gail, Barbara Leuchs, Dominik Niopek, Oskar Staufer, Maik Brune, Carsten Sticht, Norbert Gretz, Karin Müller-Decker, Hans-Peter Hammes, Peter Nawroth, Thomas Fleming, Michael D Conkright, Matthias Blüher, Anja Zeigerer, Stephan Herzig, Mauricio Berriel Diaz
Increased pro-inflammatory signaling is a hallmark of metabolic dysfunction in obesity and diabetes. Although both inflammatory and energy substrate handling processes represent critical layers of metabolic control, their molecular integration sites remain largely unknown. Here, we identify the heterodimerization interface between the α and β subunits of transcription factor GA-binding protein (GAbp) as a negative target of tumor necrosis factor alpha (TNF-α) signaling. TNF-α prevented GAbpα and β complex formation via reactive oxygen species (ROS), leading to the non-energy-dependent transcriptional inactivation of AMP-activated kinase (AMPK) β1, which was identified as a direct hepatic GAbp target...
August 8, 2017: Cell Reports
https://www.readbyqxmd.com/read/28758596/effects-of-sleeve-gastrectomy-on-the-metabolic-profile-and-on-the-expression-of-renin-angiotensin-system-in-adipose-tissue-of-obese-rats
#20
Thaísa Soares Crespo, João Marcus Oliveira Andrade, Alanna Fernandes Paraíso, Deborah de Farias Lelis, Pablo Vinicyus Ferreira Chagas, Antônio Sérgio Barcala Jorge, Wagner Leite Ferreira, Alfredo Maurício Batista de Paula, André Luiz Sena Guimarães, Sérgio Henrique Sousa Santos
Sleeve gastrectomy (SG) has been used as a multipurpose surgical procedure for the treatment of obesity. The present study assessed the effects of SG on the metabolic and inflammatory profile and renin-angiotensin system (RAS) expression in the white adipose tissue of male rats with obesity induced by a high-fat diet. Male Wistar rats were treated with a standard diet or high-fat diet and submitted to SG or sham surgery. The glycemic and lipid profiles and gene expression of inflammatory markers and RAS components in adipose tissue were evaluated...
July 28, 2017: Protein and Peptide Letters
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