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TNF-alpha and obesity

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https://www.readbyqxmd.com/read/28933980/panduratin-a-prevents-tumor-necrosis-factor-alpha-induced-muscle-atrophy-in-l6-rat-skeletal-muscle-cells
#1
Bo-Kyung Sa, Changhee Kim, Mi-Bo Kim, Jae-Kwan Hwang
Panduratin A, a prenylated chalcone compound, has anti-obesity, anti-bacterial, anti-cancer, anti-inflammatory, and anti-oxidative activities. However, its preventive effect on muscle atrophy has not been studied. The purpose of this study was to evaluate the inhibitory effect of panduratin A on muscle atrophy and to investigate its molecular mechanisms in tumor necrosis factor-alpha (TNF-α)-treated L6 rat skeletal muscle cells. Panduratin A restored the myotube diameter reduced by TNF-α. At the molecular level, panduratin A elevated phosphatidylinositol 3 kinase/Akt/mammalian target of rapamycin pathway and stimulated the MyoD and myogenin mRNA expression decreased by TNF-α...
September 21, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28923316/different-combinations-of-maternal-and-postnatal-diet-are-reflected-in-changes-of-hepatic-parenchyma-and-hepatic-tnf-alpha-expression-in-male-rat-offspring
#2
Željka Perić Kačarević, Anđela Grgić, Darija Šnajder, Nikola Bijelić, Tatjana Belovari, Olga Cvijanović, Valerija Blažičević, Radivoje Radić
Obesity is related to increased TNF-alpha production in different tissues. TNF-alpha is connected to mitochondrial dysfunction in the liver and also development of fatty infiltration of the liver. Also, postnatal change from normal to high-fat diet causes a significant increase in TNF-alpha serum levels. The aim of this research was to determine how maternal diet and switching male offspring to a different dietary regime after lactation influences rat liver. Ten female Sprague Dawley rats at nine weeks of age were randomly divided in two groups and fed either standard laboratory chow or high-fat diet during six weeks, and then mated with the same male subject...
September 15, 2017: Acta Histochemica
https://www.readbyqxmd.com/read/28894050/compounds-of-psoriasis-with-obesity-and-overweight
#3
Agnieszka Owczarczyk-Saczonek, Waldemar Placek
Many epidemiological studies have confirmed the relationship of obesity and psoriasis, and it is believed that obesity is an independent risk factor for its development and is associated with a worse prognosis. Furthermore, the reduction of body weight, using low-calorie diet combined with exercise, reduces the severity of psoriasis.Visceral adipose tissue is the largest endocrine organ, producing proinflammatory cytokines (TNF-α, IL-6, IL-17) and adipokines (adiponectin, omentin, chemerin). They participate in the development of dyslipidemia, insulin resistance, diabetes, and consequently of the cardiovascular diseases...
August 24, 2017: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/28855812/tnf-alpha-308g-a-and-238g-a-polymorphisms-and-its-protein-network-associated-with-type-2-diabetes-mellitus
#4
Kaiser Jamil, Archana Jayaraman, Javeed Ahmad, Sindhu Joshi, Shiva Kumar Yerra
Several reports document the role of tumor necrosis factor alpha (TNF-α) and lipid metabolism in the context of acute inflammation as a causative factor in obesity-associated insulin resistance and as one of the causative parameter of type 2 diabetes mellitus (T2DM). Our aim was to investigate the association between -308G/A and -238G/A polymorphisms located in the promoter region of the TNF-α gene in T2DM in the Indian population with bioinformatics analysis of TNF-α protein networking with an aim to find new target sites for the treatment of T2DM...
September 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/28839361/ethanolic-fraction-of-terminalia-tomentosa-attenuates-biochemical-and-physiological-derangements-in-diet-induced-obese-rat-model-by-regulating-key-lipid-metabolizing-enzymes-and-adipokines
#5
Balaji Meriga, Parim Brahma Naidu, Ganjayi Muniswamy, Gen Hanuma Kumar, Ramavat Ravindar Naik, Suresh Pothani
The prevalence of overweight-obesity and associated comorbidities have reached alarming levels necessitating the need to explore effective therapeutics. In the present work, we demonstrated the promising antiobesity activity of ethanolic fraction of Terminalia tomentosa bark (EFTT) in diet induced obese rat model. High Fat Diet (HFD)-fed obese rats were orally administered with EFTT (50, 100 and 200 mg/kg body weight). Changes in body weight, body composition, bone mineral concentration, bone mineral density, plasma glucose, insulin, leptin, adiponectin, circulatory and tissue lipid profiles, and the activities of liver antioxidant enzymes, key lipid metabolic enzymes and mRNA expressions of fatty acid synthase (FAS), peroxisome proliferator-activated receptor gamma (PPAR-γ), leptin and tumor necrosis factor alpha (TNF-α) were assessed in experimental rats in the presence and absence of EFTT...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28793265/a-hepatic-gabp-ampk-axis-links-inflammatory-signaling-to-systemic-vascular-damage
#6
Katharina Niopek, Bilgen Ekim Üstünel, Susanne Seitz, Minako Sakurai, Annika Zota, Frits Mattijssen, Xiaoyue Wang, Tjeerd Sijmonsma, Yvonne Feuchter, Anna M Gail, Barbara Leuchs, Dominik Niopek, Oskar Staufer, Maik Brune, Carsten Sticht, Norbert Gretz, Karin Müller-Decker, Hans-Peter Hammes, Peter Nawroth, Thomas Fleming, Michael D Conkright, Matthias Blüher, Anja Zeigerer, Stephan Herzig, Mauricio Berriel Diaz
Increased pro-inflammatory signaling is a hallmark of metabolic dysfunction in obesity and diabetes. Although both inflammatory and energy substrate handling processes represent critical layers of metabolic control, their molecular integration sites remain largely unknown. Here, we identify the heterodimerization interface between the α and β subunits of transcription factor GA-binding protein (GAbp) as a negative target of tumor necrosis factor alpha (TNF-α) signaling. TNF-α prevented GAbpα and β complex formation via reactive oxygen species (ROS), leading to the non-energy-dependent transcriptional inactivation of AMP-activated kinase (AMPK) β1, which was identified as a direct hepatic GAbp target...
August 8, 2017: Cell Reports
https://www.readbyqxmd.com/read/28758596/effects-of-sleeve-gastrectomy-on-the-metabolic-profile-and-on-the-expression-of-renin-angiotensin-system-in-adipose-tissue-of-obese-rats
#7
Thaísa Soares Crespo, João Marcus Oliveira Andrade, Alanna Fernandes Paraíso, Deborah de Farias Lelis, Pablo Vinicyus Ferreira Chagas, Antônio Sérgio Barcala Jorge, Wagner Leite Ferreira, Alfredo Maurício Batista de Paula, André Luiz Sena Guimarães, Sérgio Henrique Sousa Santos
Sleeve gastrectomy (SG) has been used as a multipurpose surgical procedure for the treatment of obesity. The present study assessed the effects of SG on the metabolic and inflammatory profile and renin-angiotensin system (RAS) expression in the white adipose tissue of male rats with obesity induced by a high-fat diet. Male Wistar rats were treated with a standard diet or high-fat diet and submitted to SG or sham surgery. The glycemic and lipid profiles and gene expression of inflammatory markers and RAS components in adipose tissue were evaluated...
July 28, 2017: Protein and Peptide Letters
https://www.readbyqxmd.com/read/28743557/a-high-fat-high-protein-diet-attenuates-the-negative-impact-of-casein-induced-chronic-inflammation-on-testicular-steroidogenesis-and-sperm-parameters-in-adult-mice
#8
Jing-Lu Zhao, Yu-Yun Zhao, Wei-Jie Zhu
The interaction between obesity and chronic inflammation has been studied. Diet-induced obesity or chronic inflammation could reduce the testicular functions of males. However, the mechanism underlying the reproductive effects of fattening foods in males with or without chronic inflammation still needs further discussion. This study was aimed to investigate the effects of high-fat, high-protein diet on testicular steroidogenesis and sperm parameters in adult mice under physiological and chronic inflammatory conditions...
October 1, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28716139/elevated-c-reactive-protein-interleukin-6-tumor-necrosis-factor-alpha-and-glycemic-load-associated-with-type-2-diabetes-mellitus-in-rural-thais-a-cross-sectional-study
#9
Chanchira Phosat, Pornpimol Panprathip, Noppanath Chumpathat, Pattaneeya Prangthip, Narisara Chantratita, Ngamphol Soonthornworasiri, Somchai Puduang, Karunee Kwanbunjan
BACKGROUND: The elevated levels of inflammatory markers, including C-reactive protein (CRP), tumor necrosis factor alpha (TNF-α), and interleukin 6 (IL6) are supposed to be associated with type 2 diabetes mellitus (T2DM). Frequent high glycemic load (GL) consumption, central obesity, and a lack of physical activity are considered to be T2DM risk factors. This study aimed to determine the difference of these inflammatory markers as well as GL in individuals with versus those without T2DM in rural Thais...
July 17, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/28703289/maresin-1-inhibits-tnf-alpha-induced-lipolysis-and-autophagy-in-3t3-l1-adipocytes
#10
Laura M Laiglesia, Silvia Lorente-Cebrián, Miguel López-Yoldi, Raquel Lanas, Neira Sáinz, J Alfredo Martínez, Maria J Moreno-Aliaga
Obesity is associated with high levels of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α), which promotes inflammation in adipose tissue. The omega-3 PUFAs, and their derived lipid mediators, such as Maresin 1 (MaR1) have anti-inflammatory effects on adipose tissue. This study aimed to analyze if MaR1 may counteract alterations induced by TNF-α on lipolysis and autophagy in mature 3T3-L1 adipocytes. Our data revealed that MaR1 (1-100 nM) inhibited the TNF-α-induced glycerol release after 48 h, which may be related to MaR1 ability of preventing the decrease in lipid droplet-coating protein perilipin and G0/G1 Switch 2 protein expression...
July 13, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28696356/rapamycin-maintains-the-chondrocytic-phenotype-and-interferes-with-inflammatory-cytokine-induced-processes
#11
Andrea De Luna-Preitschopf, Hannes Zwickl, Stefan Nehrer, Markus Hengstschläger, Mario Mikula
Osteoarthritis (OA) is hallmarked by a progressive degradation of articular cartilage. Besides risk factors including trauma, obesity or genetic predisposition, inflammation has a major impact on the development of this chronic disease. During the course of inflammation, cytokines such as tumor necrosis factor-alpha(TNF-α) and interleukin (IL)-1β are secreted by activated chondrocytes as well as synovial cells and stimulate the production of other inflammatory cytokines and matrix degrading enzymes. The mTORC1 inhibitor rapamycin is a clinical approved immunosuppressant and several studies also verified its chondroprotective effects in OA...
July 11, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28694661/relevance-of-proteolysis-and-proteasome-activation-in-fatty-liver-graft-preservation-an-institut-georges-lopez-1-vs-university-of-wisconsin-appraisal
#12
Mohamed Amine Zaouali, Arnau Panisello-Roselló, Alexandre Lopez, Carlos Castro Benítez, Emma Folch-Puy, Agustín García-Gil, Teresa Carbonell, René Adam, Joan Roselló-Catafau
AIM: To compare liver proteolysis and proteasome activation in steatotic liver grafts conserved in University of Wisconsin (UW) and Institut Georges Lopez-1 (IGL-1) solutions. METHODS: Fatty liver grafts from male obese Zücker rats were conserved in UW and IGL-1 solutions for 24 h at 4 °Cand subjected to "ex vivo" normo-thermic perfusion (2 h; 37 °C). Liver proteolysis in tissue specimens and perfusate was measured by reverse-phase high performance liquid chromatography...
June 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28634974/markers-of-subclinical-atherosclerosis-in-schoolchildren-with-obesity-and-metabolic-syndrome
#13
Alaa Al-Shorman, Hayder Al-Domi, Ahmad Faqih
BACKGROUND: Although increased carotid intima-media thickness (cIMT), soluble adhesion molecules and proinflammatory biomarkers are strongly implicated in the development of atherosclerotic lesions, the role of obesity and metabolic syndrome (MetS) in atherogenicity and inflammation among schoolchildren is not well investigated. AIM: To determine the levels of cIMT, endothelial dysfunction and inflammatory biomarkers in a group of schoolchildren with obesity and MetS...
June 21, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28614774/new-insight-into-the-direct-anti-inflammatory-activity-of-a-myokine-irisin-against-proinflammatory-activation-of-adipocytes-implication-for-exercise-in-obesity
#14
A I Mazur-Bialy, J Bilski, E Pochec, T Brzozowski
A biological activity of myokine irisin, has been intensively investigated in the context of a browning process occurring in white adipose tissue, but its role as a modulator of immune response has been little studied. The aim of our study was to determine the impact of irisin (0 - 100 nM) on pro-inflammatory activation of adipocyte 3T3 L1 cell line. Irisin reduced in a concentration-dependent manner the expression and activity of major proinflammatory cytokines, e.g. tumor necrosis factor-alpha (TNF-α) and interleukin 6 (IL-6) expression and their secretion into cell medium...
April 2017: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/28598969/cucurbitacin-e-reduces-obesity-and-related-metabolic-dysfunction-in-mice-by-targeting-jak-stat5-signaling-pathway
#15
Munazza Murtaza, Gulnaz Khan, Meha Fatima Aftab, Shabbir Khan Afridi, Safina Ghaffar, Ayaz Ahmed, Rahman M Hafizur, Rizwana Sanaullah Waraich
Several members of cucurbitaceae family have been reported to regulate growth of cancer by interfering with STAT3 signaling. In the present study, we investigated the unique role and molecular mechanism of cucurbitacins (Cucs) in reducing symptoms of metabolic syndrome in mice. Cucurbitacin E (CuE) was found to reduce adipogenesis in murine adipocytes. CuE treatment diminished hypertrophy of adipocytes, visceral obesity and lipogenesis gene expression in diet induced mice model of metabolic syndrome (MetS)...
2017: PloS One
https://www.readbyqxmd.com/read/28592311/the-effects-of-green-cardamom-on-blood-glucose-indices-lipids-inflammatory-factors-paraxonase-1-sirtuin-1-and-irisin-in-patients-with-nonalcoholic-fatty-liver-disease-and-obesity-study-protocol-for-a-randomized-controlled-trial
#16
Milad Daneshi-Maskooni, Seyed Ali Keshavarz, Siavash Mansouri, Mostafa Qorbani, Seyed Moayed Alavian, Mahtab Badri-Fariman, Seyed Ali Jazayeri-Tehrani, Gity Sotoudeh
BACKGROUND: The relationship between dietary components and nonalcoholic fatty liver disease (NAFLD) needs to be further investigated. The potential health benefits of cardamom have been found in some studies. Cardamom showed beneficial effect on hepatomegaly, dyslipidemia, and fasting hyperglycemia in animals. However, some adverse effects of cardamom have been reported in animals. No previous human study had been conducted on the effects of cardamom in NAFLD. This study aims to determine the effects of green cardamom (Elettaria cardamomum) supplementation on blood glucose indices, lipids, inflammatory profiles, and liver function, especially by examining irisin, paraxonase-1 (PON1) and sirtuin-1 (Sirt1) in obese patients with NAFLD...
June 7, 2017: Trials
https://www.readbyqxmd.com/read/28585214/the-interactions-between-kynurenine-folate-methionine-and-pteridine-pathways-in-obesity
#17
REVIEW
Ayse Basak Engin, Atilla Engin
Obesity activates both innate and adaptive immune responses in adipose tissue. Elevated levels of eosinophils with depression of monocyte and neutrophil indicate the deficiencies in the immune system of morbidly obese individuals. Actually, adipose tissue macrophages are functional antigen-presenting cells that promote the proliferation of interferon-gamma (IFN-gamma)-producing CD4+ T cells in adipose tissue of obese subjects. Eventually, diet-induced obesity is associated with the loss of tissue homeostasis and development of type 1 inflammatory responses in visceral adipose tissue...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28585206/adipocyte-macrophage-cross-talk-in-obesity
#18
REVIEW
Ayse Basak Engin
Obesity is characterized by the chronic low-grade activation of the innate immune system. In this respect, macrophage-elicited metabolic inflammation and adipocyte-macrophage interaction has a primary importance in obesity. Large amounts of macrophages are accumulated by different mechanisms in obese adipose tissue. Hypertrophic adipocyte-derived chemotactic monocyte chemoattractant protein-1 (MCP-1)/C-C chemokine receptor 2 (CCR2) pathway also promotes more macrophage accumulation into the obese adipose tissue...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28585201/the-pathogenesis-of-obesity-associated-adipose-tissue-inflammation
#19
REVIEW
Atilla Engin
Obesity is characterized by a state of chronic, low-grade inflammation. However, excessive fatty acid release may worsen adipose tissue inflammation and contributes to insulin resistance. In this case, several novel and highly active molecules are released abundantly by adipocytes like leptin, resistin, adiponectin or visfatin, as well as some more classical cytokines. Most likely cytokines that are released by inflammatory cells infiltrating obese adipose tissue are such as tumor necrosis factor-alpha (TNF-alpha), interleukin 6 (IL-6), monocyte chemoattractant protein 1 (MCP-1) (CCL-2) and IL-1...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28547566/incidence-and-predictors-of-hypoglycemia-1-year-after-laparoscopic-sleeve-gastrectomy
#20
Anna Belligoli, Marta Sanna, Roberto Serra, Roberto Fabris, Chiara Dal Pra', Scilla Conci, Paola Fioretto, Luca Prevedello, Mirto Foletto, Roberto Vettor, Luca Busetto
INTRODUCTION: Hypoglycemia is a known adverse event following gastric bypass. The incidence of hypoglycemia after laparoscopic sleeve gastrectomy (LSG) is still under investigation. The aim of our study was to verify the presence of oral glucose tolerance test (OGTT)-related hypoglycemia after LSG and to identify any baseline predictors of its occurrence. METHODS: We analyzed 197 consecutive non-diabetic morbid obese patients that underwent LSG. All patients were studied before and 12 months after LSG...
May 25, 2017: Obesity Surgery
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