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IL-1B and obesity

William D Bennett, Sally Ivins, Neil E Alexis, Jihong Wu, Philip A Bromberg, Sukhdev S Brar, Gregory Travlos, Stephanie J London
We previously observed greater ozone-induced lung function decrements in obese than non-obese women. Animal models suggest that obesity enhances ozone-induced airway reactivity and inflammation. In a controlled exposure study, we compared the acute effect of randomized 0.4ppm ozone and air exposures (2 h with intermittent light exercise) in obese (N = 20) (30<BMI<40Kg/m2) vs. non-obese (N = 20) (BMI<25Kg/m2) non-smoking 18-35 year old women. We measured spirometry and bronchial reactivity to inhaled methacholine (3h post-exposure)...
2016: PloS One
O O Znoiko, K R Dudina, A N Kozina, O V Kalinina, N D Yushchuk
The paper describes a case of ineffective dual antiviral therapy (pegylated interferon and ribavirin) in a patient with chronic hepatitis C infected with hepatitis C virus (HCV) genotype 2 according to the data from the use of a commercial test system. Analysis of the predictors of failure of antiviral therapy (AVT) (the HCV recombinant variant RF2k/1b, a high viral load before the start of therapy, an unfavorable IL-28B genotype, a high body mass index, and a need for a lower ribavirin dose after 12 weeks of AVT because of adverse reactions for less than 4 weeks) in this patient has shown that no virological response is mainly associated with the presence of the HCV recombinant variant, the treatment effectiveness of which is comparable with that in HCV genotype 1 and obesity...
2016: Terapevticheskiĭ Arkhiv
Isabel Moreno-Indias, Wilfredo Oliva-Olivera, Antonio Omiste, Daniel Castellano-Castillo, Said Lhamyani, Antonio Camargo, Francisco J Tinahones
Discordant phenotypes, metabolically healthy obese and unhealthy normal-weight individuals, are always interesting to provide important insights into the mechanistic link between adipose tissue dysfunction and associated metabolic alterations. Macrophages can release factors that impair the proper activity of the adipose tissue. Thus, studying subcutaneous and visceral adipose tissues, we investigated for the first time the differences in monocyte/macrophage infiltration, inflammation, and adipogenesis of normal-weight subjects who differed in their degree of metabolic syndrome...
June 2016: Translational Research: the Journal of Laboratory and Clinical Medicine
Luisa Vonghia, Thea Magrone, An Verrijken, Peter Michielsen, Luc Van Gaal, Emilio Jirillo, Sven Francque
BACKGROUND: Haemodynamic impairment, inflammatory mediators and glucose metabolism disturbances have been implicated in the pathogenesis of Non-Alcoholic Fatty Liver Disease (NAFLD). AIM: To investigate the cytokine profile in NAFLD patients in peripheral (P) and hepatic venous (HV) blood and to compare with histology, haemodynamic and metabolic parameters. METHODS: 40 obese patients with an indication for a transjugular liver biopsy were enrolled...
2015: PloS One
Sunsil Choi, Ji-Eun Jung, Yong Ryoul Yang, Eun-Sun Kim, Hyun-Jun Jang, Eung-Kyun Kim, Il Shin Kim, Joo-Young Lee, Joong Kwan Kim, Jeong Kon Seo, Jung-Min Kim, Jiyoung Park, Pann-Ghill Suh, Jang Hyun Choi
Chronic inflammation in adipose tissue is highly associated with insulin resistance. Herein, we demonstrate that a novel modification of PPARγ is strongly associated with inflammatory responses in adipose tissue. c-Src kinase directly phosphorylated PPARγ at Tyr78, and this process was reversed by protein tyrosine phosphatase-1B (PTP-1B). In adipocytes, phosphorylation of PPARγ suppressed the expression of pro-inflammatory genes as well as the secretion of chemokines and cytokines, thus reducing macrophage migration...
December 2015: Cellular Signalling
O Honchar, T Ashcheulova, O Kovalyova
OBJECTIVE: To investigate interrelations between interleukin 33 (IL-33) and 1B (IL-1B) serum levels and common carotid arteries (CCA) remodeling in hypertensive patients with obesity. DESIGN AND METHOD: 80 hypertensive patients (51 obese) have been observed. An ultrasound examination of CCA with estimation of its geometrical type was performed (cut-off value for vascular wall hypertrophy was vascular segment mass >0,275 g/cm, concentric remodeling was diagnosed with relative wall thickness of CCA >0,2)...
June 2015: Journal of Hypertension
Danielle Camer, Yinghua Yu, Alexander Szabo, Chi H L Dinh, Hongqin Wang, Licai Cheng, Xu-Feng Huang
High-fat (HF) diet-induced obesity is a major risk factor for the development of insulin resistance and hepatic steatosis. We examined the hypothesis that bardoxolone methyl (BM) would prevent the development of insulin resistance and hepatic steatosis in mice fed a HF diet. C57BL/6J male mice were fed a lab chow (LC), HF (40% fat), or HF diet supplemented with 10 mg/kg/day BM orally for 21 weeks. Glucose metabolism was assessed using a glucose tolerance test (GTT) and insulin sensitivity test (IST). Signalling molecules involved in insulin resistance, inflammation, and lipid metabolism were examined in liver tissue via western blotting and RT-PCR...
September 5, 2015: Molecular and Cellular Endocrinology
L Baril-Gravel, M-E Labonté, P Couture, M-C Vohl, A Charest, V Guay, D A Jenkins, P W Connelly, S West, P M Kris-Etherton, P J Jones, J A Fleming, B Lamarche
BACKGROUND AND AIMS: Little is known about the effect of various dietary fatty acids on pro- and anti-inflammatory processes. We investigated the effect of 5 oils containing various amounts of alpha-linolenic acid (ALA), linoleic acid (LA), oleic acid (OA) and docosahexaenoic acid (DHA) on plasma inflammatory biomarkers and expression levels of key inflammatory genes and transcription factors in whole blood cells. METHODS AND RESULTS: In a randomized, crossover controlled nutrition intervention, 114 adult men and women with abdominal obesity and at least one other criterion for the metabolic syndrome consumed 5 experimental isoenergetic diets for 4 weeks each, separated by 4-week washout periods...
January 2015: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
O A Gudbrandsen, Y Kodama, S A Mjøs, C-M Zhao, H Johannessen, H-R Brattbakk, C Haugen, B Kulseng, G Mellgren, D Chen
BACKGROUND: A combined procedure of sleeve gastrectomy and duodenal switch (SG+DS) has been applied to the treatment of super obesity. The aim of the present study was to test whether duodenal switch alone (DS) leads to similar weight loss and changes in lipid metabolism as SG+DS. METHODS: Male Sprague-Dawley rats underwent sham surgery (Sham, N=7), duodenal switch alone (DS, N=5) or sleeve gastrectomy followed by duodenal switch (SG+DS, N=5). Body weight, feed and water intakes, and ambulatory activity were recorded 2 months post surgery...
2014: Nutrition & Diabetes
Mohammad Nasir Uddin, Govinda Sharma, Jun-Li Yang, Hong Seok Choi, Seong-Il Lim, Keon Wook Kang, Won Keun Oh
Protein tyrosine phosphatase 1B (PTP1B) plays a key role in metabolic signaling, thereby making it an exciting drug target for type 2 diabetes and obesity. Besides, there is substantial evidence that shows its overexpression is involved in breast cancer, which suggests that selective PTP1B inhibition might be effective in breast cancer treatment. As part of our continuous research on PTP1B inhibitors from medicinal plants, four oleanane-type triterpenes were isolated from an EtOAc-soluble extract of fruit peels of Camellia japonica (Theaceae), together with 6 previously known compounds of this class...
July 2014: Phytochemistry
X F Qi, T J Feng, P Yang, H Y Feng, P Zhang, L Y Kong, D L Liang, P F Li, W Na, Y W Li, Y Wang
We aimed to investigate the association of inflammation-related genes such as IL-10, IL-6 and IL-1B with risk of ischemic stroke. We included 426 cases with ischemic stroke and 426 health controls from Xinxiang, China. Genomic DNA was extracted from the buffy coat layer of collected blood with the TIANamp blood DNA kit. Diabetes, hypertension, obesity, and smoking habits were associated with risk of ischemic stroke. We found that individuals carrying the CC genotype of IL-1B rs1864169 had a higher risk of ischemic stroke when compared with the TT genotype (OR = 1...
2014: Genetics and Molecular Research: GMR
Evgeniy Panzhinskiy, Yinan Hua, Paul A Lapchak, Elena Topchiy, Teresa E Lehmann, Jun Ren, Sreejayan Nair
Type 2 diabetes is growing at epidemic proportions, and pharmacological interventions are being actively sought. This study examined the effect of a novel neuroprotective curcuminoid, CNB-001 [4-((1E)-2-(5-(4-hydroxy-3-methoxystyryl-)-1-phenyl-1H-pyrazoyl-3-yl)vinyl)-2-methoxy-phenol], on glucose intolerance and insulin signaling in high-fat diet (HFD)-fed mice. C57BL6 mice (5-6 weeks old) were randomly assigned to receive either a HFD (45% fat) or a low-fat diet (LFD, 10% fat) for 24 weeks, together with CNB-001 (40 mg/kg i...
May 2014: Journal of Pharmacology and Experimental Therapeutics
Luca Giudici, Ana Velic, Arezoo Daryadel, Carla Bettoni, Nilufar Mohebbi, Thomas Suply, Klaus Seuwen, Marie-Gabrielle Ludwig, Carsten A Wagner
BACKGROUND: The proton-activated G protein-coupled receptor GPR4 is expressed in many tissues including white adipose tissue. GPR4 is activated by extracellular protons in the physiological pH range (i.e. pH 7.7 - 6.8) and is coupled to the production of cAMP. METHODS: We examined mice lacking GPR4 and examined glucose tolerance and insulin sensitivity in young and aged mice as well as in mice fed with a high fat diet. Expression profiles of pro- and anti-inflammatory cytokines in white adipose tissue, liver and skeletal muscle was assessed...
2013: Cellular Physiology and Biochemistry
Louise Grant, Kirsty D Shearer, Alicja Czopek, Emma K Lees, Carl Owen, Abdelali Agouni, James Workman, Cristina Martin-Granados, John V Forrester, Heather M Wilson, Nimesh Mody, Mirela Delibegovic
Protein tyrosine phosphatase-1B (PTP1B) negatively regulates insulin and leptin signaling, rendering it an attractive drug target for treatment of obesity-induced insulin resistance. However, some studies suggest caution when targeting macrophage PTP1B, due to its potential anti-inflammatory role. We assessed the role of macrophage PTP1B in inflammation and whole-body metabolism using myeloid-cell (LysM) PTP1B knockout mice (LysM PTP1B). LysM PTP1B mice were protected against lipopolysaccharide (LPS)-induced endotoxemia and hepatic damage associated with decreased proinflammatory cytokine secretion in vivo...
February 2014: Diabetes
Yonah B Esterson, Kehao Zhang, Sudha Koppaka, Sylvia Kehlenbrink, Preeti Kishore, Pooja Raghavan, Sylvan Roger Maginley, Michelle Carey, Meredith Hawkins
OBJECTIVE: The American Diabetes Association has called for further research on how patients' demographics should determine drug choices for individuals with type 2 diabetes mellitus (T2DM). Here, using in-depth physiology studies, we investigate whether obese patients with T2DM are likely to benefit from thiazolidinediones, medications with a known adverse effect of weight gain. MATERIALS AND METHODS: Eleven obese and 7 nonobese individuals with T2DM participated in this randomized, placebo-controlled, double-blind, crossover study...
December 2013: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
Machender R Kandadi, Yinan Hua, Meijun Zhu, Subat Turdi, Peter W Nathanielsz, Stephen P Ford, Sreejayan Nair, Jun Ren
Maternal overnutrition is associated with predisposition of offspring to cardiovascular disease in later life. Since maternal overnutrition may promote fetal and placental inflammatory responses, we hypothesized that maternal overnutrition/obesity increases expression of fetal cardiac proinflammatory mediators and alter cardiac morphometry. Multiparous ewes were fed either 150% of National Research Council (NRC) nutrient recommendations (overfed) or 100% of NRC requirement (control) from 60 days prior to mating to gestation Day 75 (D75), when ewes were euthanized...
November 2013: Journal of Nutritional Biochemistry
Eloize C Chiarreotto-Ropelle, Luciana S S Pauli, Carlos K Katashima, Gustavo D Pimentel, Paty K Picardi, Vagner R R Silva, Claudio T de Souza, Patrícia O Prada, Dennys E Cintra, José B C Carvalheira, Eduardo R Ropelle, José R Pauli
Hypothalamic inflammation is associated with insulin and leptin resistance, hyperphagia, and obesity. In this scenario, hypothalamic protein tyrosine phosphatase 1B (PTP1B) has emerged as the key phosphatase induced by inflammation that is responsible for the central insulin and leptin resistance. Here, we demonstrated that acute exercise reduced inflammation and PTP1B protein level/activity in the hypothalamus of obese rodents. Exercise disrupted the interaction between PTP1B with proteins involved in the early steps of insulin (IRβ and IRS-1) and leptin (JAK2) signaling, increased the tyrosine phosphorylation of these molecules, and restored the anorexigenic effects of insulin and leptin in obese rats...
September 1, 2013: American Journal of Physiology. Endocrinology and Metabolism
Christina M O'Neill, Christine Lu, Kathryn L Corbin, Poonam R Sharma, Stacey B Dula, Jeffrey D Carter, James W Ramadan, Wenjun Xin, Jae K Lee, Craig S Nunemaker
Elevated levels of circulating proinflammatory cytokines are associated with obesity and increased risk of type 2 diabetes, but the mechanism is unknown. We tested whether proinflammatory cytokines IL-1B+IL-6 at low picogram per milliliter concentrations (consistent with serum levels) could directly trigger pancreatic islet dysfunction. Overnight exposure to IL-1B+IL-6 in islets isolated from normal mice and humans disrupted glucose-stimulated intracellular calcium responses; cytokine-induced effects were more severe among islets from prediabetic db/db mice that otherwise showed no signs of dysfunction...
September 2013: Endocrinology
Nathalia R V Dragano, Anne y Castro Marques, Dennys E C Cintra, Carina Solon, Joseane Morari, Alice V Leite-Legatti, Lício A Velloso, Mário R Maróstica-Júnior
The peel of the native Brazilian fruit jaboticaba is rich in anthocyanins, which are known for their anti-obesity effects in animal models. The aim of the present study was to evaluate the effects of freeze-dried jaboticaba peel powder (FDJPP) on a number of metabolic parameters in a model of diet-induced obesity. Mice (n 8 per group) were initially fed on a high-fat diet (HFD, 35% w/w) for 4 weeks and then switched to a HFD supplemented with FDJPP (1, 2 or 4% w/w) for an additional 6 weeks. Energy intake, weight loss, glucose tolerance, insulin resistance and lipid profile were determined, and the results were evaluated using ANOVA and Tukey’s tests...
August 28, 2013: British Journal of Nutrition
Francisco José Tinahones, Leticia Coín Aragüez, Mora Murri, Wilfredo Oliva Olivera, María Dolores Mayas Torres, Nuria Barbarroja, Ricardo Gomez Huelgas, Maria M Malagón, Rajaa El Bekay
OBJECTIVE: Cell death determines the onset of obesity and associated insulin resistance. Here, we analyze the relationship among obesity, adipose tissue apoptosis, and insulin signaling. RESEARCH DESIGN AND METHODS: The expression levels of initiator (CASP8/9) and effector (CASP3/7) caspases as well as antiapoptotic B-cell lymphoma (BCL)2 and inflammatory markers were assessed in visceral (VAT) and subcutaneous (SAT) adipose tissue from patients with different degrees of obesity and without insulin resistance or diabetes...
March 2013: Diabetes Care
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