keyword
MENU ▼
Read by QxMD icon Read
search

IL-6 and obesity

keyword
https://www.readbyqxmd.com/read/28646706/corn-silk-maysin-ameliorates-obesity-in-vitro-and-in-vivo-via-suppression-of-lipogenesis-differentiation-and-function-of-adipocytes
#1
Chang Won Lee, Jeong Yeon Seo, Sun-Lim Kim, Jisun Lee, Ji Won Choi, Yong Il Park
Present study was aimed to investigate the potential anti-obesity effects of maysin, a major flavonoid of corn silk, in vitro and in vivo using 3T3-L1 preadipocyte cells and C57BL/6 mice. Maysin decreased the levels of intracellular lipid droplets and triglycerides (TG), and down-regulated the protein expression levels of C/EBP-β, C/EBP-α, PPAR-γ, and aP2 in 3T3-L1 preadipocyte cells, suggesting that maysin inhibits lipid accumulation and adipocyte differentiation. In addition, maysin was shown to induce the apoptotic cell death in 3T3-L1 preadipocyte cells via activation of caspase cascades and mitochondrial dysfunction, which may ultimately lead to reduction of adipose tissue mass...
June 21, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28644409/quercetin-protects-obesity-induced-hypothalamic-inflammation-by-reducing-microglia-mediated-inflammatory-responses-via-ho-1-induction
#2
Jihyeon Yang, Chu-Sook Kim, Thai Hien Tu, Min-Seon Kim, Tsuyoshi Goto, Teruo Kawada, Myung-Sook Choi, Taesun Park, Mi-Kyung Sung, Jong Won Yun, Suck-Young Choe, Jee Hye Lee, Yeonsoo Joe, Hye-Seon Choi, Sung Hoon Back, Hun Taeg Chung, Rina Yu
Obesity-induced hypothalamic inflammation is characterized by activation of microglia, which are resident macrophages of the central nervous system, and is implicated in the derangement of energy homeostasis, metabolic complications, and neurodegenerative diseases. Quercetin, a naturally occurring flavonoid, is known to protect against oxidative stress and inflammation-related metabolic complications. Here, we demonstrate that quercetin reduces obesity-induced hypothalamic inflammation by inhibiting microglia-mediated inflammatory responses, and the beneficial action of quercetin is associated with heme oxygenase (HO-1) induction...
June 23, 2017: Nutrients
https://www.readbyqxmd.com/read/28638270/existence-of-a-strong-correlation-of-biomarkers-and-mirna-in-females-with-metabolic-syndrome-and-obesity-in-a-population-of-west-virginia
#3
Perrine Goguet-Rubio, Rebecca L Klug, Dana L Sharma, Krithika Srikanthan, Nitin Puri, Vishal H Lakhani, Alexandra Nichols, Kathleen M O'Hanlon, Nader G Abraham, Joseph I Shapiro, Komal Sodhi
Objectives: Metabolic syndrome causes complications like cardiovascular disease and type 2 diabetes mellitus (T2DM). As metabolic syndrome develops, altered levels of cytokines and microRNAs (miRNA) are measurable in the circulation. We aimed to construct a panel detecting abnormal levels of cytokines and miRNAs in patients at risk for metabolic syndrome. Methods: Participants included 54 patients from a Family Medicine Clinic at Marshall University School of Medicine, in groups of: Control, Obese, and Metabolic Syndrome (MetS)...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/28638220/green-tea-polyphenols-ameliorate-non-alcoholic-fatty-liver-disease-through-upregulating-ampk-activation-in-high-fat-fed-zucker-fatty-rats
#4
Yi Tan, Jane Kim, Jing Cheng, Madeleine Ong, Wei-Guo Lao, Xing-Liang Jin, Yi-Guang Lin, Linda Xiao, Xue-Qiong Zhu, Xian-Qin Qu
AIM: To investigate protective effects and molecular mechanisms of green tea polyphenols (GTP) on non-alcoholic fatty liver disease (NAFLD) in Zucker fatty (ZF) rats. METHODS: Male ZF rats were fed a high-fat diet (HFD) for 2 wk then treated with GTP (200 mg/kg) or saline (5 mL/kg) for 8 wk, with Zucker lean rat as their control. At the end of experiment, serum and liver tissue were collected for measurement of metabolic parameters, alanine aminotransferase (ALT) and aspartate aminotransferase (AST), inflammatory cytokines and hepatic triglyceride and liver histology...
June 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28638152/combination-of-a-high-fat-diet-with-sweetened-condensed-milk-exacerbates-inflammation-and-insulin-resistance-induced-by-each-separately-in-mice
#5
Laureane Nunes Masi, Amanda Roque Martins, Amanda Rabello Crisma, Cátia Lira do Amaral, Mariana Rodrigues Davanso, Tamires Duarte Afonso Serdan, Roberta Dourado Cavalcante da Cunha de Sá, Maysa Mariana Cruz, Maria Isabel Cardoso Alonso-Vale, Rosângela Pavan Torres, Jorge Mancini-Filho, Joice Naiara Bertaglia Pereira, Marta Maria da Silva Righetti, Edson Aparecido Liberti, Sandro Massao Hirabara, Rui Curi
Obesogenic diets increase body weight and cause insulin resistance (IR), however, the association of these changes with the main macronutrient in the diet remains to be elucidated. Male C57BL/6 mice were fed with: control (CD), CD and sweetened condensed milk (HS), high-fat (HF), and HF and condensed milk (HSHF). After 2 months, increased body weight, glucose intolerance, adipocyte size and cholesterol levels were observed. As compared with CD, HS ingested the same amount of calories whereas HF and HSHF ingested less...
June 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28631923/influence-of-ingesting-a-flavonoid-rich-supplement-on-the-metabolome-and-concentration-of-urine-phenolics-in-overweight-obese-women
#6
David C Nieman, Sivapriya Ramamoorthy, Colin D Kay, Courtney L Goodman, Christopher R Capps, Zach L Shue, Nicole Heyl, Mary H Grace
This study evaluated the effect of ingesting a flavonoid-rich supplement (329 mg/d) on total urine phenolics and shifts in plasma metabolites in overweight/obese female adults using untargeted metabolomics procedures. Participants (N=103, 18-65 y, BMI ≥ 25 kg/m2) were randomized to flavonoid (F) or placebo (P) groups for 12 weeks, with blood and 24-h urine samples collected pre-study, 4- and 12-weeks in a parallel design. Supplements were prepared as chewable tablets, and included vitamin C, wild bilberry fruit extract, green tea leaf extract, quercetin, caffeine, and omega 3 fatty acids...
June 20, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28630461/antrodia-cinnamomea-reduces-obesity-and-modulates-the-gut-microbiota-in-high-fat-diet-fed-mice
#7
C-J Chang, C-C Lu, C-S Lin, J Martel, Y-F Ko, D M Ojcius, T-R Wu, Y-H Tsai, T-S Yeh, J-J Lu, H-C Lai, J D Young
BACKGROUND: Obesity is associated with gut microbiota dysbiosis, disrupted intestinal barrier and chronic inflammation. Given the high and increasing prevalence of obesity worldwide, anti-obesity treatments that are safe, effective and widely available would be beneficial. We examined whether the medicinal mushroom Antrodia cinnamomea may reduce obesity in mice fed with a high-fat diet (HFD). METHODS: Male C57BL/6J mice were fed a HFD for eight weeks to induce obesity and chronic inflammation...
June 20, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28628401/dietary-red-and-processed-meat-intake-and-markers-of-adiposity-and-inflammation-the-multiethnic-cohort-study
#8
Weiwen Chai, Yukiko Morimoto, Robert V Cooney, Adrian A Franke, Yurii B Shvetsov, Loïc Le Marchand, Christopher A Haiman, Laurence N Kolonel, Marc T Goodman, Gertraud Maskarinec
OBJECTIVE: The potential influence of dietary factors on inflammation is important for cancer prevention. Utilizing data from control participants (312 men, 911 women) in 2 nested case-control studies of cancer within the Multiethnic Cohort, we examined the associations of red and processed meat intake with serum levels of leptin, adiponectin, C-reactive protein (CRP), tumor necrosis factor (TNF)-α, and interleukin (IL)-6 and the mediator effect of body mass index (BMI) on the above associations (if present)...
June 19, 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/28627656/adipokines-and-free-fatty-acids-regulate-insulin-sensitivity-by-increasing-microrna-21-expression-in-human-mature-adipocytes
#9
Nannan Zhang, Naijian Zhang, Leilei Song, Hui Xie, Chao Zhao, Sujuan Li, Wenxi Zhao, Yaping Zhao, Chunlin Gao, Guangfeng Xu
Obesity is a global public health concern and may lead to a variety of complications. Previous studies have indicated that adipokines and energy‑source materials contribute to obesity and obesity‑associated insulin resistance. MicroRNAs (miRs) are endogenous 20‑ to 25‑nucleotide non‑coding RNAs associated with fat metabolism. It has been indicated that miR‑21 is associated with adipogenesis and metabolic syndrome. In the present study, the expression of miR‑21 in human mature adipocytes was analyzed using reverse transcription quantitative‑polymerase chain reaction following treatment with adipokines, including tumor necrosis factor (TNF)‑α, interleukin (IL)‑6, leptin, resistin and energy source materials, including free fatty acids (FFAs) and glucose...
June 14, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28625915/high-fat-diet-induced-obesity-increases-myocardial-injury-and-alters-cardiac-stat3-signaling-in-mice-after-polymicrobial-sepsis
#10
Theodore DeMartini, Marchele Nowell, Jeanne James, Lauren Williamson, Patrick Lahni, Hui Shen, Jennifer M Kaplan
Little is known about how obesity affects the heart during sepsis and we sought to investigate the obesity-induced cardiac effects that occur during polymicrobial sepsis. Six-week old C57BL/6 mice were randomized to a high fat (HFD) (60% kcal fat) or normal diet (ND) (16% kcal fat). After 6 wks of feeding, mice were anesthetized with isoflurane and polymicrobial sepsis was induced by cecal ligation and puncture (CLP). Plasma and cardiac tissue were obtained for analysis. Echocardiography was performed on a separate cohort of mice at 0 and 18h after CLP...
June 15, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28625035/programming-of-infant-neurodevelopment-by-maternal-obesity-potential-role-of-maternal-inflammation-and-insulin-resistance
#11
Mira Dewi, Susan E Carlson, Kathleen M Gustafson, Debra K Sullivan, Jo A Wick, Holly R Hull
BACKGROUND AND OBJECTIVES: Recent studies show that maternal obesity is associated with impaired offspring neurodevelopmental outcomes. The mechanism underlying the association is unclear. However, there is evidence to suggest a role for intra-uterine exposure to inflammation and insulin resistance (IR). We aimed to determine if maternal IR and inflammation were associated to fetal neurodevelopment as indicated by fetal heart rate variability (HRV), an index of fetal cardiac autonomic nervous system development...
June 2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28620678/effect-of-lifestyle-improvement-program-on-the-biomarkers-of-adiposity-inflammation-and-gut-hormones-in-overweight-obese-asian-indians-with-prediabetes
#12
Kuppan Gokulakrishnan, Harish Ranjani, Mary Beth Weber, Gautam Kumar Pandey, Ranjit Mohan Anjana, Muthuswamy Balasubramanyam, Dorairaj Prabhakaran, Nikhil Tandon, K M Venkat Narayan, Viswanathan Mohan
AIMS: While lifestyle modification is known to offer several metabolic benefits, there is paucity of comprehensive data on changes in biomarkers of adiposity, inflammation as well as gut hormones. We investigated these biomarkers in overweight/obese individuals with prediabetes randomized to either 4 months of a lifestyle improvement program or standard care and followed them up for a year. METHODS: Participants [standard care and intervention arm (n = 75 each)] were randomly selected from the Diabetes Community Lifestyle Improvement Program trial...
June 15, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28617537/spirulina-maxima-improves-insulin-sensitivity-lipid-profile-and-total-antioxidant-status-in-obese-patients-with-well-treated-hypertension-a-randomized-double-blind-placebo-controlled-study
#13
M Szulinska, M Gibas-Dorna, E Miller-Kasprzak, J Suliburska, A Miczke, M Walczak-Gałezewska, M Stelmach-Mardas, J Walkowiak, P Bogdanski
OBJECTIVE: Spirulina maxima consumption is known to be associated with enhanced cardiovascular and metabolic health. Human studies on this topic have recently been described in a few papers; however, potential protective cardiovascular properties of Spirulina in obese patients receiving standard pharmacological antihypertensive treatment remain to be elucidated. Putative beneficial cardiovascular effects of Spirulina supplementation in well treated, obesity-related hypertension were studied in a double-blind placebo-controlled trial...
May 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28615667/il-6-secretion-in-osteoarthritis-patients-is-mediated-by-chondrocyte-synovial-fibroblast-cross-talk-and-is-enhanced-by-obesity
#14
Mark J Pearson, Dietmar Herndler-Brandstetter, Mohammad A Tariq, Thomas A Nicholson, Ashleigh M Philp, Hannah L Smith, Edward T Davis, Simon W Jones, Janet M Lord
Increasing evidence suggests that inflammation plays a central role in driving joint pathology in certain patients with osteoarthritis (OA). Since many patients with OA are obese and increased adiposity is associated with chronic inflammation, we investigated whether obese patients with hip OA exhibited differential pro-inflammatory cytokine signalling and peripheral and local lymphocyte populations, compared to normal weight hip OA patients. No differences in either peripheral blood or local lymphocyte populations were found between obese and normal-weight hip OA patients...
June 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28614774/new-insight-into-the-direct-anti-inflammatory-activity-of-a-myokine-irisin-against-proinflammatory-activation-of-adipocytes-implication-for-exercise-in-obesity
#15
A I Mazur-Bialy, J Bilski, E Pochec, T Brzozowski
A biological activity of myokine irisin, has been intensively investigated in the context of a browning process occurring in white adipose tissue, but its role as a modulator of immune response has been little studied. The aim of our study was to determine the impact of irisin (0 - 100 nM) on pro-inflammatory activation of adipocyte 3T3 L1 cell line. Irisin reduced in a concentration-dependent manner the expression and activity of major proinflammatory cytokines, e.g. tumor necrosis factor-alpha (TNF-α) and interleukin 6 (IL-6) expression and their secretion into cell medium...
April 2017: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/28607107/myeloid-sirtuin-6-deficiency-causes-insulin-resistance-in-high-fat-diet-fed-mice-by-eliciting-macrophage-polarization-toward-an-m1-phenotype
#16
Youngyi Lee, Sun-O Ka, Hye-Na Cha, Yu-Na Chae, Mi-Kyung Kim, So-Young Park, Eun Ju Bae, Byung-Hyun Park
Obesity-related insulin resistance is closely associated with macrophage accumulation and subsequent cytokine release in local tissues. Sirtuin (Sirt) 6 is known to exert an anti-inflammatory function but its role in macrophages in the context of obesity has not been investigated. Here, we generated myeloid-specific Sirt6 knockout mice (mS6KO) and investigated the metabolic characteristics after high-fat diet (HFD) feeding for 16 weeks. Compared with their wild type littermates, HFD-fed mS6KO mice exhibited greater increases in body weight, fasting blood glucose- and insulin-levels, hepatic steatosis, glucose intolerance, and insulin resistance...
June 12, 2017: Diabetes
https://www.readbyqxmd.com/read/28606092/hyperlipidemic-microenvironment-conditionates-damage-mechanisms-in-human-chondrocytes-by-oxidative-stress
#17
Daniel Medina-Luna, Mónica Guadalupe Santamaría-Olmedo, Yessica Zamudio-Cuevas, Karina Martínez-Flores, Javier Fernández-Torres, Gabriela Angélica Martínez-Nava, Denise Clavijo-Cornejo, Cristina Hernández-Díaz, Anell Olivos-Meza, Luis Enrique Gomez-Quiroz, María Concepción Gutiérrez-Ruiz, Carlos Pineda, Francisco Blanco, Anthony M Reginato, Alberto López-Reyes
BACKGROUND: Currently, two pathogenic pathways describe the role of obesity in osteoarthritis (OA); one through biomechanical stress, and the other by the contribution of systemic inflammation. The aim of this study was to evaluate the effect of free fatty acids (FFA) in human chondrocytes (HC) expression of proinflammatory factors and reactive oxygen species (ROS). METHODS: HC were exposed to two different concentrations of FFA in order to evaluate the secretion of adipokines through cytokines immunoassays panel, quantify the protein secretion of FFA-treated chondrocytes, and fluorescent cytometry assays were performed to evaluate the reactive oxygen species (ROS) production...
June 12, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28604755/physical-exercise-intervention-at-school-improved-hepcidin-inflammation-and-iron-metabolism-in-overweight-and-obese-children-and-adolescents
#18
Susana Coimbra, Cristina Catarino, Henrique Nascimento, Ana Inês Alves, Ana Filipa Medeiros, Elsa Bronze-da-Rocha, Elísio Costa, Petronila Rocha-Pereira, Luísa Aires, André Seabra, Jorge Mota, Helena Ferreira Mansilha, Carla Rêgo, Alice Santos-Silva, Luís Belo
BACKGROUND: Obesity is often associated with iron deficiency in children and adolescents. We aimed to study the effect of 8-month physical exercise (PE) intervention in hepcidin and other markers of inflammation and in iron status in overweight/obese children and adolescents. METHODS: Seventy-three overweight/obese children and adolescents participated in the 8-month longitudinal study; they were divided in two groups according to their participation in an after-school PE program: PE (n=44) and control (n=29) groups...
June 12, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28603178/role-of-adipokines-in-cardiovascular-disease
#19
Wayne Bond Lau, Koji Ohashi, Yajing Wang, Hayato Ogawa, Toyoaki Murohara, Xin-Liang Ma, Noriyuki Ouchi
Cardiovascular disease (CVD) is the greatest cause of death, accounting for nearly one-third of all deaths worldwide. The increase in obesity rates over 3 decades is widespread and threatens the public health in both developed and developing countries. Obesity, the excessive accumulation of visceral fat, causes the clustering of metabolic disorders, such as type 2 diabetes, dyslipidemia, and hypertension, culminating in the development of CVD. Adipose tissue is not only an energy storage organ, but an active endocrine tissue producing various biologically active proteins known as adipokines...
June 10, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28599253/alantolactone-improves-palmitate-induced-glucose-intolerance-and-inflammation-in-both-lean-and-obese-states-in-vitro-adipocyte-and-adipocyte-macrophage-co-culture-system
#20
Minjee Kim, Kwangho Song, Yeong Shik Kim
Obesity is characterized by a massive infiltration of the adipose tissue by macrophages. Adipocytes, together with macrophages create a crosstalk between inflammation and insulin resistance. Excess saturated FFA, such as palmitate, absorbed via the portal system may cause glucose intolerance and inflammation, which leads to insulin resistance. In this study, we aimed to evaluate the potency of alantolactone (AL), a sesquiterpene lactone isolated from Inula helenium in reducing palmitate-induced glucose intolerance, fat accumulation, and inflammation in 3T3-L1 adipocytes and adipocyte-macrophage co-culture system (3T3-L1-RAW264...
June 6, 2017: International Immunopharmacology
keyword
keyword
75520
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"