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IL-6 and obesity

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https://www.readbyqxmd.com/read/29142617/acute-strenuous-exercise-induces-an-imbalance-on-histone-h4-acetylation-histone-deacetylase-2-and-increases-the-proinflammatory-profile-of-pbmc-of-obese-individuals
#1
Gilson P Dorneles, Maria Carolina R Boeira, Lucas L Schipper, Ivy R V Silva, Viviane R Elsner, Pedro Dal Lago, Alessandra Peres, Pedro R T Romão
This study evaluated the response of global histone H4 acetylation (H4ac), histone deacetylase 2 (HDAC2) activity, as well as the production of proinflammatory cytokines and monocyte phenotypes of lean and obese males after exercise. Ten lean and ten obese sedentary men were submitted to one session of strenuous exercise, and peripheral blood mononuclear cells (PBMC) were stimulated in vitro with lipopolysaccharide (LPS). Global H4ac levels, HDAC2 activity in PBMC, and IL-6, IL-8, and TNF-α production were analyzed...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29141038/depot-specific-inflammation-with-decreased-expression-of-atm2-in-white-adipose-tissues-induced-by-high-margarine-lard-intake
#2
Nannan Wang, Jie Guo, Fuding Liu, Mingxia Wang, Chuntao Li, Lihong Jia, Lingling Zhai, Wei Wei, Yinglong Bai
A high-fat diet has been recognized as an important risk factor of obesity, with variable impacts of different fatty acid compositions on the physiological process. To understand the effects of a high-margarine/lard diet, which is a major source of trans fatty acids (TFAs)/ saturated fatty acids (SFAs), elaidic acid as a biomarker of margarine intake was used to screen affected adipokines on mature human adipocytes in vitro. Weaned male Wistar rats were fed a high-fat diet enriched with margarine/lard to generate obesity-prone (OP) and obesity-resistant (OR) models, which were then used to explore the inflammatory responses of depot-specific white adipose tissue...
2017: PloS One
https://www.readbyqxmd.com/read/29137196/high-expression-of-stat3-in-subcutaneous-adipose-tissue-associates-with-cardiovascular-risk-in-women-with-rheumatoid-arthritis
#3
Mitra Nadali, Rille Pullerits, Karin M E Andersson, Sofia Töyrä Silfverswärd, Malin C Erlandsson, Maria I Bokarewa
Despite the predominance of female patients and uncommon obesity, rheumatoid arthritis (RA) is tightly connected to increased cardiovascular morbidity. The aim of this study was to investigate transcriptional activity in the subcutaneous white adipose tissue (WAT) with respect to this disproportionate cardiovascular risk (CVR) in RA. CVR was estimated in 182 female patients, using the modified Systematic Coronary Risk Evaluation scale, and identified 93 patients with increased CVR. The overall transcriptional activity in WAT was significantly higher in patients with CVR and was presented by higher serum levels of WAT products leptin, resistin and IL-6 (all, p < 0...
November 13, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29135515/association-between-allergic-and-nonallergic-rhinitis-and-obstructive-sleep-apnea
#4
Ming Zheng, Xiangdong Wang, Luo Zhang
PURPOSE OF REVIEW: Allergic rhinitis and nonallergic rhinitis (NAR) are common disorders, which have been considered as potential risk factors for obstructive sleep apnea (OSA). This review summarizes the proposed underlying pathophysiological mechanisms to provide a better understanding of the relationship between these conditions. RECENT FINDINGS: In adults, allergic rhinitis and NAR may be considered as symptoms potentiating, rather than risk potentiating factors in the pathophysiology of OSA, whereas in children, these are considered to be independent predictors for sleep-disordered breathing (SDB) and failure of adeno-tonsillectomy, the recommended first-line therapy for children with OSA...
November 14, 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29132429/characterization-of-skin-function-associated-with-obesity-and-specific-correlation-to-local-systemic-parameters-in-american-women
#5
Shinobu Mori, Akiko Shiraishi, Karen Epplen, Desiree Butcher, Daiki Murase, Yuka Yasuda, Takatoshi Murase
BACKGROUND: Obesity is considered problematic not only as a major cause of diabetes, hypertension, and dyslipidemia, but also as a risk of intractable dermatosis; however influence of obesity on skin function has not been clarified. To clarify the mechanism of obesity-associated skin disorders, we aimed to characterize the skin function of subjects with obesity, and identify possible influencing factors. METHODS: Complex analyses including instrumental measurement, biochemical and lipidomics were performed for facial skin and physical evaluation in 93 Caucasian women with obesity (OB) and non-obesity (NOB)...
November 13, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29122953/dietary-weight-loss-induced-changes-in-rbp4-ffa-and-ace-predict-weight-regain-in-people-with-overweight-and-obesity
#6
Roel G Vink, Nadia J Roumans, Edwin C Mariman, Marleen A van Baak
Adipokines and other biomarkers were previously identified with roles in energy expenditure, appetite, satiety, and adiposity. Therefore, we investigated whether dietary weight loss-induced changes in adipokines and other biomarkers known to play a role in weight regulation or energy expenditure could predict weight regain in people with overweight and obesity. In this randomized controlled trial 26 males and 30 females (BMI: 28-35 kg/m(2)) followed either a low-calorie diet (LCD; 1250 kcal/day) for 12 weeks or a very-low-calorie diet (VLCD; 500 kcal/day) for 5 weeks followed by a weight stable period of 4 weeks (dietary intervention (DI) period) and a 9-month follow-up period...
November 2017: Physiological Reports
https://www.readbyqxmd.com/read/29121420/obesity-during-pregnancy-in-the-mouse-alters-the-netrin-1-responsiveness-of-fetal-arcuate-nucleus-npy-neurons
#7
Tessa R Sanders, Kelly A Glendining, Christine L Jasoni
When individuals undergo gestation in an obese dam, they are at increased risk for impairments in the brain's ability to regulate body weight. In rodents, gestation in an obese dam leads to a number of changes to the development of the hypothalamic neurons that regulate body weight, including reduced neuronal connectivity at birth. Here, we sought to gain a clearer picture of how this neural circuitry develops normally, and to explore the mechanism underpinning the deficiency in connectivity seen in fetuses developing in obese dams...
November 9, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29118012/effects-and-mechanisms-of-caffeine-to-improve-immunologic-and-metabolic-abnormalities-in-diet-induced-obese-rats
#8
Chih-Wei Liu, Hung-Cheng Tsai, Chia-Chang Huang, Chang-Youh Tsai, Yen-Bo Su, Ming-Wei Lin, Kuei Chuan Lee, Yun-Cheng Hsieh, Tzu-Hao Li, Shiang-Fen Huang, Ying-Ying Yang, Ming-Chih Hou, Han-Chieh Lin, Fa-Yauh Lee, Shou-Dong Lee
In obesity, there are no effective therapies for parallel immune and metabolic abnormalities including systemic/tissue insulin-resistance/inflammation, adiposity and hepatic steatosis. Caffeine has anti-inflammation, anti-hepatic steatosis and anti-insulin-resistance effects. In this study, we evaluated the effects and molecular mechanisms of 6-week of caffeine treatment (HFD-caf) on immunologic and metabolic abnormalities of high-fat diet (HFD)-induced obese rats. In comparison with HFD-V rats, in HFD-caf rats the suppressed circulating immune cell inflammatory [TNFα, MCP-1, IL-6, intercellular adhesion molecule1 (ICAM-1) and nitrite] profiles were accompanied by decreased liver, white adipose tissue (WAT) and muscle' macrophages and its intracellular cytokines levels...
November 7, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29115635/a-potential-role-for-hepcidin-in-obesity-driven-colorectal-tumourigenesis
#9
Elisabeth Phillips, Richard D Horniblow, Vikki Poole, Matthew Bedford, Douglas G Ward, Amanda J Kirkham, Jeremy Tomlinson, Tariq H Iqbal, Chris Tselepis
The obesity epidemic is associated with increases in the incidence of several types of cancer, including colorectal cancer, and is associated with poor outcomes for patients. Adipose tissue is considered biologically active and represents a plausible link between cancer and obesity due to the many factors that it secretes. In the present study, human adipose tissue was cultured in vitro and predifferentiated adipocyte secretome [preadipocyte (PAS)] and differentiated adipocyte secretome (DAS) were collected...
October 31, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29115454/mycoleptodonoides%C3%A2-aitchisonii-suppresses-asthma-via-th2-and-th1-cell-regulation-in-an-ovalbumin%C3%A2-induced-asthma-mouse-model
#10
Soon-Young Lee, Chun-Sik Bae, Ji-Hye Seo, Seung Sik Cho, Min-Suk Bae, Deuk-Sil Oh, Dae-Hun Park
Asthma is a chronic respiratory disease related to hyper‑responsiveness. The majority of patients suffer mild symptoms, however, some cases, especially in the young and the elderly, can lead to death by apnea. Mycoleptodonoides atichisonii (M. atichisonii) is an edible mushroom that has previously been reported to possess several bioactive properties, such as the synthesis of nerve growth factors, anti‑obesity effects and the ability to prevent cell death. In the current study, the authors evaluated the anti‑asthmatic effects of M...
October 26, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29113135/nonalcoholic-fatty-liver-disease-is-exacerbated-in-high-fat-diet-fed-gnotobiotic-mice-by-colonization-with-the-gut-microbiota-from-patients-with-nonalcoholic-steatohepatitis
#11
Chien-Chao Chiu, Yung-Hao Ching, Yen-Peng Li, Ju-Yun Liu, Yen-Te Huang, Yi-Wen Huang, Sien-Sing Yang, Wen-Ching Huang, Hsiao-Li Chuang
Nonalcoholic fatty liver disease (NAFLD) is a serious liver disorder associated with the accumulation of fat and inflammation. The objective of this study was to determine the gut microbiota composition that might influence the progression of NAFLD. Germ-free mice were inoculated with feces from patients with nonalcoholic steatohepatitis (NASH) or from healthy persons (HL) and then fed a standard diet (STD) or high-fat diet (HFD). We found that the epididymal fat weight, hepatic steatosis, multifocal necrosis, and inflammatory cell infiltration significantly increased in the NASH-HFD group...
November 6, 2017: Nutrients
https://www.readbyqxmd.com/read/29111391/short-term-effects-of-adjunctive-antimicrobial-photodynamic-therapy-in-obese-patients-with-chronic-periodontitis-a-randomized-controlled-clinical-trial
#12
Fahim Vohra, Zohaib Akram, Ishfaq A Bukhari, Saeed A Sheikh, Fawad Javed
BACKGROUND: The aim of the present study was to assess the effect of antimicrobial photodynamic therapy (aPDT) as an adjunct to scaling and root planing (SRP) on clinical periodontal and immunological parameters in obese patients with chronic periodontitis (CP). METHODS: Fifty-three obese with CP patients were divided into 2 groups receiving aPDT with SRP and SRP only respectively. Full-mouth plaque index (PI), bleeding on probing (BOP), pocket depth (PD) and clinical attachment level (CAL) were assessed at baseline, 6 and 12 weeks post-therapy...
October 27, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29103822/ziprasidone-a-second-generation-antipsychotic-drug-triggers-a-macrophage-inflammatory-response-in-vitro
#13
Thiago Duarte, Fernanda Barbisan, Pedro Antônio Schmidt do Prado-Lima, Verônica Farina Azzolin, Ivo Emílio da Cruz Jung, Marta Maria Medeiros Frescura Duarte, Cibele Ferreira Teixeira, Moises Henrique Mastella, Ivana Beatrice Mânica da Cruz
Antipsychotic drugs are used to treat schizophrenia and other psychiatric disorders. However, most of these drugs present side effects causing obesity and other serious metabolic alterations that correlate with grade of chronic inflammation. In contrast, ziprasidone's (ZIP) metabolic side effects are attenuated relative to those of other antipsychotic drugs, but some reports suggest that this drug could cause allergic, hypersensitive reactions in susceptible patients. At present, the mechanism of ZIP's effect on peripheral inflammatory metabolism is not well characterized...
November 2, 2017: Cytokine
https://www.readbyqxmd.com/read/29103176/oncostatin-m-in-the-development-of-metabolic-syndrome-and-its-potential-as-a-novel-therapeutic-target
#14
REVIEW
Tadasuke Komori, Yoshihiro Morikawa
Oncostatin M (OSM), a member of the IL-6 family of cytokines, plays an important role in various biologic actions, including cell growth, neuronal development, and inflammatory responses. Recently, we demonstrated the unique relationship between OSM and metabolic syndrome in mice. Mice lacking OSM receptor β subunit (OSMRβ(-/-) mice) exhibited late-onset obesity. Before the onset of obesity, adipose tissue inflammation and insulin resistance were observed in OSMRβ(-/-) mice. In addition, high-fat diet-induced metabolic disorders, including obesity, adipose tissue inflammation, insulin resistance, and hepatic steatosis, were aggravated in OSMRβ(-/-) mice compared to those in wild-type mice...
November 4, 2017: Anatomical Science International
https://www.readbyqxmd.com/read/29101672/association-between-leptin-and-il-6-concentrations-with-cardiovascular-risk-in-patients-with-rheumatoid-arthritis
#15
José Antonio De Jesús Batún-Garrido, Marisol Salas-Magaña, Isela Esther Juárez-Rojop
Pro-inflammatory cytokines such as leptin and IL-6 play an important role in the development of cardiovascular risk. Determine the relationship between leptin and IL-6 concentrations with cardiovascular risk in patients with rheumatoid arthritis. We determined IL-6 and leptin levels in 77 patients with the diagnosis of rheumatoid arthritis. The cardiovascular risk was calculated using the modified Framingham scale. Statistical analysis was performed using SPSS 22 considering a significant p < 0.05. Serum leptin concentrations and cardiovascular risk (CVR) factors were compared and found that there was a significant difference between higher leptin values and disease activity (p 0...
November 3, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29099041/inflammatory-biomarkers-of-cardiometabolic-risk-in-obese-egyptian-type-2-diabetics
#16
Lamiaa A A Barakat, Hassan A Shora, Ibrahim M El-Deen, El-Sayed Abd El-Sameeh El-Sayed
Inflammatory biomarkers provide a minimally invasive means for early detection and specific treatment of metabolic syndrome and related disorders. The objective of this work was to search for inflammatory biomarkers of cardiometabolic risk in obese type 2 diabetics. The study was performed on 165 persons attending the medical outpatient clinic of Ismailia General Hospital. Their mean age was (50.69 ± 10.15) years. They were divided into three groups. The control group was composed of 55 non-obese, non-diabetic healthy volunteers, 32 males and 23 females...
November 2, 2017: Medical Sciences: Open Access Journal
https://www.readbyqxmd.com/read/29095915/interaction-of-il-6-and-tnf-%C3%AE-contributes-to-endothelial-dysfunction-in-type-2-diabetic-mouse-hearts
#17
Jonghae Lee, Sewon Lee, Hanrui Zhang, Michael A Hill, Cuihua Zhang, Yoonjung Park
OBJECTIVES: Inflammatory cytokines, such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), are individually considered as important contributors to endothelial dysfunction in obesity and type 2 diabetes (T2D). However, their interactions in coronary arteriole endothelial dysfunction are uncertain. Therefore, this study aimed to determine the effects of TNF-α and IL-6 interactions on coronary endothelial dysfunction in experimental T2D. METHODS: The studies used wild type (WT), diabetic mice (db/db), db/db null for TNF (dbTNF-/dbTNF-), and db/db mice treated with neutralizing antibody to IL-6 (anti-IL-6)...
2017: PloS One
https://www.readbyqxmd.com/read/29090232/clinical-significance-of-serum-il-6-and-tnf-%C3%AE-levels-in-patients-with-metabolic-syndrome
#18
Mojgan Mohammadi, Mohammad Hossein Gozashti, Majid Aghadavood, Mohammad Reza Mehdizadeh, Mohammad Mahdi Hayatbakhsh
BACKGROUND: Several components of metabolic syndrome (MetS) facilitate its diagnosis, including abdominal obesity, hyperlipidemia, high blood pressure, and insulin resistance. The production of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) seem to be associated with MetS components. The aim of this study was to evaluate the correlation between IL-6 and TNF-α serum levels with MetS and its components. METHODS: This case-control study investigated 250 subjects, comprising 125 healthy controls from the Kerman Blood Transfusion Organization and 125 MetS patients...
October 2017: Reports of Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/29089335/the-effects-of-periconceptional-maternal-alcohol-intake-and-a-postnatal-high-fat-diet-on-obesity-and-liver-disease-in-male-and-female-rat-offspring
#19
Emelie M Gardebjer, James S M Cuffe, Leigh C Ward, Sarah Steane, Stephen T Anderson, Emily S Dorey, Jacinta I Kalisch-Smith, Marie Pantaleon, Suyinn Chong, Lisa Yamada, Mary E Wlodek, Helle Bielefeldt-Ohmann, Karen M Moritz
The effects of maternal alcohol consumption around the time of conception on offspring are largely unknown and difficult to determine in a human population. This study utilized a rodent model to examine if periconceptional alcohol (PC:EtOH), alone or in combination with a postnatal high-fat diet (HFD) resulted in obesity and liver dysfunction. Sprague-Dawley rats were fed a control or ethanol-containing liquid diet (12.5% EtOH v/v) from 4 days prior to mating until 4 days of gestation (n=12/group). A subset of offspring was fed a HFD between 3-8 months of age...
October 31, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29081799/swim-training-attenuates-inflammation-and-improves-insulin-sensitivity-in-mice-fed-with-a-high-fat-diet
#20
Guangzeng Zhang, Pengfei Yu, Xiaomeng Liu
Exercise could afford multiple beneficial effects on obesity-related metabolic disorders. To address this issue, C57BL/6J mice were used to investigate the effects of 13 weeks of swim training on HFD-induced obesity and related insulin resistance and inflammation. Our results show that swim training can significantly prevent HFD-induced weight gain and increase resting energy expenditure without affecting food intake. The insulin sensitivity was enhanced in the HFD + swim group than in the HFD + sedentary group...
2017: International Journal of Endocrinology
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